TBC1D20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to a family of GTPase activator proteins of Rab-like small GTPases. The encoded protein and its cognate GTPase, Rab1, bind the nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) to mediate viral replication. Depletion of this protein inhibits replication of the virus and HCV infection. Mutations in this gene are associated with Warburg micro syndrome 4. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)5.48845520
2regulation of sequestering of triglyceride (GO:0010889)4.65631919
3regulation of cholesterol storage (GO:0010885)4.60481316
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.24815715
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.24815715
6regulation of fatty acid beta-oxidation (GO:0031998)3.82043072
7fatty acid transmembrane transport (GO:1902001)3.79699483
8valine metabolic process (GO:0006573)3.72397596
9antigen processing and presentation of endogenous antigen (GO:0019883)3.67436826
10carnitine shuttle (GO:0006853)3.64258596
11regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.62515706
12positive regulation of fatty acid beta-oxidation (GO:0032000)3.56495938
13apoptotic cell clearance (GO:0043277)3.55430676
14positive regulation of histone deacetylation (GO:0031065)3.54085237
15regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.53460300
16regulation of fatty acid oxidation (GO:0046320)3.53368701
17carnitine transmembrane transport (GO:1902603)3.52829061
18peptidyl-glutamic acid carboxylation (GO:0017187)3.46749861
19protein carboxylation (GO:0018214)3.46749861
20amino-acid betaine transport (GO:0015838)3.42214832
21carnitine transport (GO:0015879)3.42214832
22positive regulation of fatty acid oxidation (GO:0046321)3.36754185
23antigen processing and presentation via MHC class Ib (GO:0002475)3.36610953
24triglyceride catabolic process (GO:0019433)3.30411537
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.22765987
26positive regulation of lipid storage (GO:0010884)3.22412604
27negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.17388738
28pentose-phosphate shunt (GO:0006098)3.17215417
29positive regulation of extracellular matrix organization (GO:1903055)3.15910823
30regulation of extracellular matrix disassembly (GO:0010715)3.15599489
31white fat cell differentiation (GO:0050872)3.15318245
32alpha-linolenic acid metabolic process (GO:0036109)3.13250875
33growth hormone receptor signaling pathway (GO:0060396)3.11471907
34neutral lipid catabolic process (GO:0046461)3.05986601
35acylglycerol catabolic process (GO:0046464)3.05986601
36sexual reproduction (GO:0019953)3.03845987
37COPII vesicle coating (GO:0048208)3.03505024
38negative regulation of lipid storage (GO:0010888)3.02711312
39cellular response to arsenic-containing substance (GO:0071243)3.00568615
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.00145031
41protein localization to endosome (GO:0036010)2.95927584
42Golgi transport vesicle coating (GO:0048200)2.94779378
43COPI coating of Golgi vesicle (GO:0048205)2.94779378
44positive regulation of lipid catabolic process (GO:0050996)2.94674977
45negative regulation of cell size (GO:0045792)2.92779999
46fusion of sperm to egg plasma membrane (GO:0007342)2.91098424
47fatty acid beta-oxidation (GO:0006635)2.90981671
48macroautophagy (GO:0016236)2.90923244
49NADPH regeneration (GO:0006740)2.90155340
50cytoplasmic mRNA processing body assembly (GO:0033962)2.89038446
51intracellular lipid transport (GO:0032365)2.86733959
52brown fat cell differentiation (GO:0050873)2.85840832
53negative regulation of type 2 immune response (GO:0002829)2.85121049
54negative regulation of fatty acid transport (GO:2000192)2.81188349
55tricarboxylic acid metabolic process (GO:0072350)2.79251508
56cellular response to growth hormone stimulus (GO:0071378)2.77366337
57mannose metabolic process (GO:0006013)2.74685336
58lipid storage (GO:0019915)2.74351574
59cell wall macromolecule catabolic process (GO:0016998)2.74078184
60cell wall macromolecule metabolic process (GO:0044036)2.74078184
61biotin metabolic process (GO:0006768)2.73554594
62positive regulation of glycolytic process (GO:0045821)2.72892883
63plasma lipoprotein particle clearance (GO:0034381)2.72276930
64positive regulation of p38MAPK cascade (GO:1900745)2.71981065
65regulation of memory T cell differentiation (GO:0043380)2.70278199
66sperm motility (GO:0030317)2.68786642
67positive regulation of triglyceride metabolic process (GO:0090208)2.68473504
68regulation of early endosome to late endosome transport (GO:2000641)2.62782740
69regulation of triglyceride catabolic process (GO:0010896)2.62192749
70JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.62097736
71fatty acid oxidation (GO:0019395)2.61517195
72protein heterotrimerization (GO:0070208)2.58796937
73activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.57937214
74regulation of macrophage derived foam cell differentiation (GO:0010743)2.57767520
75quaternary ammonium group transport (GO:0015697)2.56792901
76lipid oxidation (GO:0034440)2.54144417
77regulation of extracellular matrix organization (GO:1903053)2.53277254
78regulation of lipid storage (GO:0010883)2.52692389
79positive regulation of receptor recycling (GO:0001921)2.51923529
80regulation of cholesterol homeostasis (GO:2000188)2.50837652
81positive regulation of blood vessel endothelial cell migration (GO:0043536)2.49699951
82negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.49529036
83positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.49289517
84hypotonic response (GO:0006971)2.48403724
85fatty acid catabolic process (GO:0009062)2.47853589
86endodermal cell differentiation (GO:0035987)2.46661453
87positive regulation of protein deacetylation (GO:0090312)2.46204240
88regulation of membrane protein ectodomain proteolysis (GO:0051043)2.44447095
89positive regulation of fatty acid metabolic process (GO:0045923)2.44282519
90positive regulation of nuclease activity (GO:0032075)2.42829042
91triglyceride biosynthetic process (GO:0019432)2.42029879
92iron ion import (GO:0097286)2.42013325
93positive regulation of triglyceride biosynthetic process (GO:0010867)2.40873519
94negative regulation of fibrinolysis (GO:0051918)2.40104211
95epithelial cell differentiation involved in prostate gland development (GO:0060742)2.39889159
96collagen fibril organization (GO:0030199)2.39849346
97regulation of lipid catabolic process (GO:0050994)2.39576605
98regulation of metalloenzyme activity (GO:0048552)2.39038934
99glucose catabolic process (GO:0006007)2.37444798
100regulation of p38MAPK cascade (GO:1900744)2.37183805
101negative regulation of granulocyte differentiation (GO:0030853)2.35657930
102chondrocyte proliferation (GO:0035988)2.34108729
103stress fiber assembly (GO:0043149)2.33958463
104positive regulation of cellular response to insulin stimulus (GO:1900078)2.33449027
1052-oxoglutarate metabolic process (GO:0006103)2.28852788
106neutral lipid biosynthetic process (GO:0046460)2.28779463
107acylglycerol biosynthetic process (GO:0046463)2.28779463
108negative regulation of Ras GTPase activity (GO:0034261)2.28708830
109blood vessel maturation (GO:0001955)2.28600232
110regulation of interleukin-12 biosynthetic process (GO:0045075)2.28185538
111lipoprotein transport (GO:0042953)2.27421841
112negative regulation of erythrocyte differentiation (GO:0045647)2.27155633
113carnitine metabolic process (GO:0009437)2.26824524
114cellular response to lithium ion (GO:0071285)2.26815561
1154-hydroxyproline metabolic process (GO:0019471)2.26258602
116cell-substrate junction assembly (GO:0007044)2.26198655
117skin morphogenesis (GO:0043589)2.25458216
118endoplasmic reticulum unfolded protein response (GO:0030968)2.25333784
119negative regulation of innate immune response (GO:0045824)2.25174417
120venous blood vessel morphogenesis (GO:0048845)2.24183653
121CDP-diacylglycerol metabolic process (GO:0046341)2.23588614
122regulation of amyloid precursor protein catabolic process (GO:1902991)2.23086956
123cellular response to vitamin (GO:0071295)2.23082423
124basement membrane organization (GO:0071711)2.22775759
125regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.22569083
126vascular endothelial growth factor signaling pathway (GO:0038084)2.22496855
127phospholipid homeostasis (GO:0055091)2.22119063
128triglyceride metabolic process (GO:0006641)2.21837994
129insulin-like growth factor receptor signaling pathway (GO:0048009)2.20852539
130endocardial cushion development (GO:0003197)2.19257650
131regulation of beta-amyloid formation (GO:1902003)2.19208257
132positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.15670516
133protein-lipid complex assembly (GO:0065005)2.14897882
134cell adhesion mediated by integrin (GO:0033627)2.14714708
135vesicle coating (GO:0006901)2.11764664
136fibril organization (GO:0097435)2.09065239
137focal adhesion assembly (GO:0048041)2.07461845
138cell-substrate adherens junction assembly (GO:0007045)2.07461845
139regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.04294330
140cortical actin cytoskeleton organization (GO:0030866)2.04094467
141positive regulation of fibroblast migration (GO:0010763)2.03421710
142regulation of ARF GTPase activity (GO:0032312)2.03130495
143extracellular fibril organization (GO:0043206)2.03106562
144regulation of apoptotic cell clearance (GO:2000425)2.02971362
145negative regulation of endocytosis (GO:0045806)2.01202234
146branching involved in mammary gland duct morphogenesis (GO:0060444)2.00206573
147regulation of fibrinolysis (GO:0051917)1.99867297
148plasma lipoprotein particle assembly (GO:0034377)1.98900424
149maintenance of protein localization in endoplasmic reticulum (GO:0035437)1.98787540
150positive regulation of transforming growth factor beta production (GO:0071636)1.98321414
151sequestering of extracellular ligand from receptor (GO:0035581)1.98232042
152extracellular matrix assembly (GO:0085029)1.97768014
153regulation of transforming growth factor beta1 production (GO:0032908)1.97361556
154negative regulation of Ras protein signal transduction (GO:0046580)1.97261117
155retrograde transport, endosome to Golgi (GO:0042147)1.96668091
156import into cell (GO:0098657)1.95801491
157protein retention in ER lumen (GO:0006621)1.95534438
158stress granule assembly (GO:0034063)1.95419025
159eosinophil chemotaxis (GO:0048245)1.95004781
160positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr1.94918154
161regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)1.92155155
162barbed-end actin filament capping (GO:0051016)1.91745068
163regulation of ARF protein signal transduction (GO:0032012)1.91568602
164cellular response to nutrient (GO:0031670)1.91236037
165protein hydroxylation (GO:0018126)1.90565150
166negative regulation of receptor-mediated endocytosis (GO:0048261)1.89652904
167regulation of integrin-mediated signaling pathway (GO:2001044)1.89409129
168retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)1.88656092
169chondroitin sulfate catabolic process (GO:0030207)1.88226898
170peptidyl-proline hydroxylation (GO:0019511)1.87444568
171regulation of plasminogen activation (GO:0010755)1.87126607
172negative regulation of protein localization to plasma membrane (GO:1903077)1.86805023
173endocytic recycling (GO:0032456)1.86304841
174protein targeting to plasma membrane (GO:0072661)1.86152627
175adhesion of symbiont to host (GO:0044406)1.85991537
176adherens junction assembly (GO:0034333)1.85090685
177chondroitin sulfate biosynthetic process (GO:0030206)1.84507999
178negative regulation of small GTPase mediated signal transduction (GO:0051058)1.84330112
179establishment of protein localization to vacuole (GO:0072666)1.83789790
180protein targeting to vacuole (GO:0006623)1.83789790

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.23293020
2TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.16614296
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.02280431
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.02168604
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.53118224
6* CLOCK_20551151_ChIP-Seq_293T_Human2.51483660
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.51449050
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.38564975
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.29012811
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28495199
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.23066298
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.22212353
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11712902
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05660237
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.03643200
16ZNF263_19887448_ChIP-Seq_K562_Human2.03543479
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.98110889
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.95362997
19MYC_22102868_ChIP-Seq_BL_Human1.95074856
20TCF7_22412390_ChIP-Seq_EML_Mouse1.92464763
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87951614
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.83729076
23IRF8_27001747_Chip-Seq_BMDM_Mouse1.81964357
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.81613001
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80985789
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.80503604
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.79202325
28* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.74989069
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.73365096
30VDR_21846776_ChIP-Seq_THP-1_Human1.72561294
31* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71560920
32* KDM2B_26808549_Chip-Seq_DND41_Human1.69529170
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63807948
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62186746
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59579102
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59460606
37* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59013731
38LXR_22292898_ChIP-Seq_THP-1_Human1.57572584
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.57007111
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56338322
41MAF_26560356_Chip-Seq_TH1_Human1.56293278
42RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.53199453
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51401805
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.47718800
45* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.47697828
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47305785
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47109949
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45135418
49RACK7_27058665_Chip-Seq_MCF-7_Human1.44564573
50EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44395894
51ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43258955
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41544989
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41453624
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40163553
55* VDR_24763502_ChIP-Seq_THP-1_Human1.39223472
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.38693608
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38267361
58* FOXA2_19822575_ChIP-Seq_HepG2_Human1.38060384
59FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.36949899
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33725097
61* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32634180
62GATA1_22025678_ChIP-Seq_K562_Human1.32150577
63UTX_26944678_Chip-Seq_JUKART_Human1.31196407
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29298158
65ATF3_27146783_Chip-Seq_COLON_Human1.28702300
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28652021
67TBX20_22328084_ChIP-Seq_HEART_Mouse1.28173005
68TBX20_22080862_ChIP-Seq_HEART_Mouse1.28173005
69SPI1_23127762_ChIP-Seq_K562_Human1.27814903
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26239025
71MYB_26560356_Chip-Seq_TH2_Human1.26041225
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25843020
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25421838
74TRIM28_21343339_ChIP-Seq_HEK293_Human1.23445825
75NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23133807
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22864531
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.22561635
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.20601949
79SCL_19346495_ChIP-Seq_HPC-7_Human1.18117623
80NCOR1_26117541_ChIP-Seq_K562_Human1.17770018
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.17306829
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.17044546
83JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16782031
84FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15744496
85GATA1_19941826_ChIP-Seq_K562_Human1.15681171
86GATA1_19941827_ChIP-Seq_MEL_Mouse1.15515497
87EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15135712
88CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15093356
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14059930
90HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13356918
91WT1_19549856_ChIP-ChIP_CCG9911_Human1.12873782
92MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12529468
93ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11886834
94MYB_26560356_Chip-Seq_TH1_Human1.11692309
95SMC1_22415368_ChIP-Seq_MEFs_Mouse1.11531540
96STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10801788
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10678655
98TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10303179
99JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09973789
100* KDM2B_26808549_Chip-Seq_JURKAT_Human1.09963817
101ESR1_21235772_ChIP-Seq_MCF-7_Human1.09962739
102CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09071261
103VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09011718
104STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08506612
105RUNX1_27514584_Chip-Seq_MCF-7_Human1.08122611
106ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08018920
107DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07811896
108UBF1/2_26484160_Chip-Seq_HMECs_Human1.05376908
109BCOR_27268052_Chip-Seq_Bcells_Human1.04998910
110MAF_26560356_Chip-Seq_TH2_Human1.02215283
111TP53_23651856_ChIP-Seq_MEFs_Mouse1.00442318
112GATA6_25053715_ChIP-Seq_YYC3_Human0.99871356
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99776931
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98984152
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98782588
116GATA2_19941826_ChIP-Seq_K562_Human0.97969842
117CJUN_26792858_Chip-Seq_BT549_Human0.97506296
118ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96068116
119VDR_24787735_ChIP-Seq_THP-1_Human0.96066968
120GATA3_27048872_Chip-Seq_THYMUS_Human0.95783703
121GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95558706
122ELF1_20517297_ChIP-Seq_JURKAT_Human0.95469411
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95122229
124DROSHA_22980978_ChIP-Seq_HELA_Human0.94994257
125P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94943269
126MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94667587
127TP53_22127205_ChIP-Seq_IMR90_Human0.93714437
128CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93672302
129BRD4_25478319_ChIP-Seq_HGPS_Human0.93272577
130NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92686205
131P68_20966046_ChIP-Seq_HELA_Human0.92352813
132ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92295429
133CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92276032
134CREB1_26743006_Chip-Seq_LNCaP_Human0.92014342
135PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91806239
136GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91378657
137GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91340986
138KDM2B_26808549_Chip-Seq_K562_Human0.90522524
139SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90412564
140SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90412564
141PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90235416

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose3.83584951
2MP0003705_abnormal_hypodermis_morpholog3.31318501
3MP0008438_abnormal_cutaneous_collagen3.29589698
4MP0004185_abnormal_adipocyte_glucose2.73419190
5MP0005666_abnormal_adipose_tissue2.71287872
6MP0004130_abnormal_muscle_cell2.61486105
7MP0003300_gastrointestinal_ulcer2.47799673
8MP0005058_abnormal_lysosome_morphology2.37696391
9MP0005503_abnormal_tendon_morphology2.25509841
10MP0003191_abnormal_cellular_cholesterol2.15916402
11MP0005409_darkened_coat_color2.15168511
12MP0005410_abnormal_fertilization2.09800650
13MP0005275_abnormal_skin_tensile2.07377468
14MP0005375_adipose_tissue_phenotype2.05753085
15MP0003303_peritoneal_inflammation1.97164555
16MP0003566_abnormal_cell_adhesion1.87448777
17MP0009840_abnormal_foam_cell1.87049077
18MP0010234_abnormal_vibrissa_follicle1.80341815
19MP0010352_gastrointestinal_tract_polyps1.77974979
20MP0003329_amyloid_beta_deposits1.73235443
21MP0010329_abnormal_lipoprotein_level1.72141435
22MP0003436_decreased_susceptibility_to1.70497460
23MP0000566_synostosis1.63715796
24MP0009384_cardiac_valve_regurgitation1.63383915
25MP0005451_abnormal_body_composition1.61223001
26MP0002971_abnormal_brown_adipose1.60870945
27MP0008260_abnormal_autophagy1.56196083
28MP0000371_diluted_coat_color1.48562203
29MP0002166_altered_tumor_susceptibility1.47840061
30MP0005076_abnormal_cell_differentiation1.47497357
31MP0009278_abnormal_bone_marrow1.46029132
32MP0000003_abnormal_adipose_tissue1.44460566
33MP0003656_abnormal_erythrocyte_physiolo1.44071089
34MP0009115_abnormal_fat_cell1.42272184
35MP0005365_abnormal_bile_salt1.41799490
36MP0000013_abnormal_adipose_tissue1.41203416
37MP0003950_abnormal_plasma_membrane1.40415981
38MP0001958_emphysema1.40344311
39MP0008961_abnormal_basal_metabolism1.39099067
40MP0002877_abnormal_melanocyte_morpholog1.36925589
41MP0000767_abnormal_smooth_muscle1.36547087
42MP0004233_abnormal_muscle_weight1.33202514
43MP0000609_abnormal_liver_physiology1.31657053
44MP0005360_urolithiasis1.29756654
45MP0001835_abnormal_antigen_presentation1.28797493
46MP0002139_abnormal_hepatobiliary_system1.28556354
47MP0002896_abnormal_bone_mineralization1.27404525
48MP0006054_spinal_hemorrhage1.26312558
49MP0004947_skin_inflammation1.24530073
50MP0002118_abnormal_lipid_homeostasis1.23976261
51MP0004510_myositis1.23354121
52MP0008004_abnormal_stomach_pH1.22226052
53MP0003279_aneurysm1.21923708
54MP0001533_abnormal_skeleton_physiology1.21492263
55MP0003045_fibrosis1.21382675
56MP0000343_altered_response_to1.21337807
57MP0001545_abnormal_hematopoietic_system1.19889173
58MP0005397_hematopoietic_system_phenotyp1.19889173
59MP0000685_abnormal_immune_system1.19695259
60MP0000015_abnormal_ear_pigmentation1.18803768
61MP0003172_abnormal_lysosome_physiology1.17593008
62MP0005508_abnormal_skeleton_morphology1.16281385
63MP0001915_intracranial_hemorrhage1.15827511
64MP0005023_abnormal_wound_healing1.15361795
65MP0005464_abnormal_platelet_physiology1.13272703
66MP0005334_abnormal_fat_pad1.12552850
67MP0002089_abnormal_postnatal_growth/wei1.11034000
68MP0002419_abnormal_innate_immunity1.10950619
69MP0002933_joint_inflammation1.09578622
70MP0003448_altered_tumor_morphology1.09531290
71MP0002006_tumorigenesis1.06972589
72MP0002060_abnormal_skin_morphology1.06706447
73MP0000534_abnormal_ureter_morphology1.04572066
74MP0003091_abnormal_cell_migration1.04220099
75MP0010307_abnormal_tumor_latency1.03216858
76MP0002970_abnormal_white_adipose1.00857813
77MP0009643_abnormal_urine_homeostasis1.00702349
78MP0002998_abnormal_bone_remodeling1.00550221
79MP0005319_abnormal_enzyme/_coenzyme1.00414846
80MP0005164_abnormal_response_to1.00054467
81MP0001666_abnormal_nutrient_absorption0.99880869
82MP0005390_skeleton_phenotype0.99816500
83MP0000858_altered_metastatic_potential0.98714815
84MP0009780_abnormal_chondrocyte_physiolo0.98572046
85MP0004858_abnormal_nervous_system0.96911893
86MP0000569_abnormal_digit_pigmentation0.96872226
87MP0003724_increased_susceptibility_to0.96458306
88MP0005257_abnormal_intraocular_pressure0.95328483
89MP0002295_abnormal_pulmonary_circulatio0.93810060
90MP0005000_abnormal_immune_tolerance0.93314671
91MP0002452_abnormal_antigen_presenting0.92184857
92MP0001790_abnormal_immune_system0.91953577
93MP0005387_immune_system_phenotype0.91953577
94MP0005083_abnormal_biliary_tract0.90580037
95MP0001881_abnormal_mammary_gland0.88931263
96MP0000733_abnormal_muscle_development0.88056321
97MP0004087_abnormal_muscle_fiber0.87740879
98MP0001845_abnormal_inflammatory_respons0.87686465
99MP0000604_amyloidosis0.87346742
100MP0001270_distended_abdomen0.87329355
101MP0002837_dystrophic_cardiac_calcinosis0.86972333
102MP0003075_altered_response_to0.86647588
103MP0003646_muscle_fatigue0.86593896
104MP0005025_abnormal_response_to0.85908594
105MP0009785_altered_susceptibility_to0.85877130
106MP0001542_abnormal_bone_strength0.84452987
107MP0005167_abnormal_blood-brain_barrier0.83974988
108MP0004272_abnormal_basement_membrane0.83710373
109MP0001661_extended_life_span0.83523935
110MP0010368_abnormal_lymphatic_system0.83456688
111MP0003115_abnormal_respiratory_system0.83452714
112MP0001756_abnormal_urination0.82838172
113MP0005171_absent_coat_pigmentation0.81904675
114MP0000598_abnormal_liver_morphology0.81771156
115MP0008469_abnormal_protein_level0.81639960
116MP0010155_abnormal_intestine_physiology0.81119359
117MP0010630_abnormal_cardiac_muscle0.80638750
118MP0001800_abnormal_humoral_immune0.80560396
119MP0003453_abnormal_keratinocyte_physiol0.79159107
120MP0005584_abnormal_enzyme/coenzyme_acti0.79088440
121MP0001849_ear_inflammation0.78900849
122MP0003252_abnormal_bile_duct0.75817145
123MP0000428_abnormal_craniofacial_morphol0.75776873
124MP0002420_abnormal_adaptive_immunity0.75392022
125MP0002136_abnormal_kidney_physiology0.75348589
126MP0001819_abnormal_immune_cell0.75215543
127MP0002723_abnormal_immune_serum0.74745745
128MP0006082_CNS_inflammation0.74447801
129MP0002108_abnormal_muscle_morphology0.73419111
130MP0003690_abnormal_glial_cell0.73236386
131MP0002168_other_aberrant_phenotype0.73136607
132MP0002078_abnormal_glucose_homeostasis0.72360500
133MP0004808_abnormal_hematopoietic_stem0.72198261
134MP0005408_hypopigmentation0.71733793
135MP0002075_abnormal_coat/hair_pigmentati0.71510844
136MP0003942_abnormal_urinary_system0.70922602
137MP0000249_abnormal_blood_vessel0.70837684
138MP0004381_abnormal_hair_follicle0.70406895
139MP0003879_abnormal_hair_cell0.69040682
140MP0001175_abnormal_lung_morphology0.68552123
141MP0002113_abnormal_skeleton_development0.67665835
142MP0002128_abnormal_blood_circulation0.67663145
143MP0001664_abnormal_digestion0.67366653
144MP0000920_abnormal_myelination0.66618944
145MP0003183_abnormal_peptide_metabolism0.65826050
146MP0003868_abnormal_feces_composition0.63063033
147MP0005174_abnormal_tail_pigmentation0.61713763
148MP0001614_abnormal_blood_vessel0.61171149

Predicted human phenotypes

RankGene SetZ-score
1Vascular tortuosity (HP:0004948)3.62525030
2Cerebral aneurysm (HP:0004944)3.57519856
3Arterial tortuosity (HP:0005116)3.45131920
4Nasal polyposis (HP:0100582)3.39206501
5Protrusio acetabuli (HP:0003179)3.29034906
6Abnormality of the nasal mucosa (HP:0000433)3.27279265
7Vertebral compression fractures (HP:0002953)3.00820359
8Premature rupture of membranes (HP:0001788)2.93219066
9Mitral stenosis (HP:0001718)2.91956685
10Myocardial infarction (HP:0001658)2.91829496
11Soft skin (HP:0000977)2.88434011
12Ankle contracture (HP:0006466)2.80684164
13Bladder diverticulum (HP:0000015)2.75733926
14Aortic aneurysm (HP:0004942)2.72231301
15Increased cerebral lipofuscin (HP:0011813)2.70279410
16Autoimmune thrombocytopenia (HP:0001973)2.70267055
17Hematochezia (HP:0002573)2.64468622
18Increased connective tissue (HP:0009025)2.62494860
19Eczematoid dermatitis (HP:0000976)2.58989074
20Wormian bones (HP:0002645)2.58800072
21Osteolytic defects of the hand bones (HP:0009699)2.55984609
22Osteolytic defects of the phalanges of the hand (HP:0009771)2.55984609
23Myoglobinuria (HP:0002913)2.51809540
24Aortic dissection (HP:0002647)2.49711291
25Asymmetric septal hypertrophy (HP:0001670)2.46875587
26Ovoid vertebral bodies (HP:0003300)2.45450630
27Oligomenorrhea (HP:0000876)2.43509847
28Urinary glycosaminoglycan excretion (HP:0003541)2.41844425
29Mucopolysacchariduria (HP:0008155)2.41844425
30Follicular hyperkeratosis (HP:0007502)2.38790322
31Blue sclerae (HP:0000592)2.38766685
32Abnormality of proline metabolism (HP:0010907)2.36637259
33Hydroxyprolinuria (HP:0003080)2.36637259
34Aneurysm (HP:0002617)2.35507852
35Dysostosis multiplex (HP:0000943)2.35062329
36Spondylolisthesis (HP:0003302)2.34507846
37Hemorrhage of the eye (HP:0011885)2.34471802
38Flared iliac wings (HP:0002869)2.33440377
39Dilatation of the ascending aorta (HP:0005111)2.32865900
40Xanthomatosis (HP:0000991)2.32621393
41Cervical subluxation (HP:0003308)2.32578684
42Gingival bleeding (HP:0000225)2.32294105
43Atrophic scars (HP:0001075)2.32037431
44Neonatal short-limb short stature (HP:0008921)2.31685353
45Hand muscle atrophy (HP:0009130)2.31360998
46Distal upper limb amyotrophy (HP:0007149)2.29709287
47Upper limb amyotrophy (HP:0009129)2.29709287
48Fragile skin (HP:0001030)2.29594557
49Mitral valve prolapse (HP:0001634)2.28982909
50Hypertriglyceridemia (HP:0002155)2.26541545
51Peritonitis (HP:0002586)2.25812941
52Hyperglycinuria (HP:0003108)2.25176461
53Broad metatarsal (HP:0001783)2.24663435
54Action tremor (HP:0002345)2.24561468
55Acanthosis nigricans (HP:0000956)2.21100631
56Long toe (HP:0010511)2.20427186
57Tetraparesis (HP:0002273)2.20316896
58Interstitial pulmonary disease (HP:0006530)2.19999836
59Complement deficiency (HP:0004431)2.19791755
60Abnormality of mucopolysaccharide metabolism (HP:0011020)2.17783630
61Abnormality of polysaccharide metabolism (HP:0011012)2.17783630
62Abnormality of glycosaminoglycan metabolism (HP:0004371)2.17783630
63Polycythemia (HP:0001901)2.17223542
64Obstructive sleep apnea (HP:0002870)2.17056843
65Dysmetric saccades (HP:0000641)2.17026179
66Flat acetabular roof (HP:0003180)2.15714897
67Hyperextensible skin (HP:0000974)2.14089077
68Venous insufficiency (HP:0005293)2.11385928
69Purpura (HP:0000979)2.10640730
70Abnormality of the acetabulum (HP:0003170)2.09727853
71Mitral regurgitation (HP:0001653)2.08092978
72Type 1 muscle fiber predominance (HP:0003803)2.07665018
73Shallow orbits (HP:0000586)2.07176356
74Abnormality of fatty-acid metabolism (HP:0004359)2.05978899
75Thin bony cortex (HP:0002753)2.04911788
76Bone cyst (HP:0012062)2.03939295
77Enlarged penis (HP:0000040)2.02672943
78Spinal rigidity (HP:0003306)2.02614758
79Rhabdomyolysis (HP:0003201)2.01808591
80Difficulty running (HP:0009046)2.01641570
81Hypoglycemic coma (HP:0001325)2.01633482
82Insulin-resistant diabetes mellitus (HP:0000831)2.00570868
83Neurofibrillary tangles (HP:0002185)2.00171832
84Recurrent gram-negative bacterial infections (HP:0005420)1.98071295
85Venous abnormality (HP:0002624)1.97953242
86Hypoalphalipoproteinemia (HP:0003233)1.97377485
87Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.96810606
88Joint laxity (HP:0001388)1.96722111
89Reduced subcutaneous adipose tissue (HP:0003758)1.96302453
90Increased neuronal autofluorescent lipopigment (HP:0002074)1.94509610
91Difficulty climbing stairs (HP:0003551)1.94250652
92Loss of speech (HP:0002371)1.94225765
93Skin nodule (HP:0200036)1.93824440
94Menorrhagia (HP:0000132)1.92158672
95Right ventricular cardiomyopathy (HP:0011663)1.91768460
96Abnormal cartilage morphology (HP:0002763)1.91533028
97Ulnar bowing (HP:0003031)1.90199013
98Abnormality of liposaccharide metabolism (HP:0010968)1.89979571
99Abnormality of glycosphingolipid metabolism (HP:0004343)1.89979571
100Abnormality of glycolipid metabolism (HP:0010969)1.89979571
101Recurrent abscess formation (HP:0002722)1.89052533
102Abnormality of complement system (HP:0005339)1.88292625
103Global brain atrophy (HP:0002283)1.87967449
104Male infertility (HP:0003251)1.87891388
105Disproportionate tall stature (HP:0001519)1.86987440
106Cellulitis (HP:0100658)1.86985505
107Recurrent bacterial skin infections (HP:0005406)1.86902080
108Aortic regurgitation (HP:0001659)1.86660688
109Facial diplegia (HP:0001349)1.86034221
110Hyporeflexia of lower limbs (HP:0002600)1.85771670
111Hypercholesterolemia (HP:0003124)1.84861367
112Axonal loss (HP:0003447)1.83536012
113Colitis (HP:0002583)1.83506945
114Slow saccadic eye movements (HP:0000514)1.83353286
115Lymphangioma (HP:0100764)1.83025453
116Bruising susceptibility (HP:0000978)1.80936369
117Dislocated radial head (HP:0003083)1.80530316
118Overgrowth (HP:0001548)1.79405137
119Genu recurvatum (HP:0002816)1.79076582
120Polygenic inheritance (HP:0010982)1.78314557
121Systemic lupus erythematosus (HP:0002725)1.77945219
122Multiple enchondromatosis (HP:0005701)1.77495371
123Joint stiffness (HP:0001387)1.77072145
124Striae distensae (HP:0001065)1.75654927
125Ketosis (HP:0001946)1.75486049
126Gastrointestinal infarctions (HP:0005244)1.75448565
127Slender build (HP:0001533)1.74542562
128Vacuolated lymphocytes (HP:0001922)1.73359343
129Fatigue (HP:0012378)1.73339779
130Periodontitis (HP:0000704)1.72809405
131Conjunctival hamartoma (HP:0100780)1.72698597
132Osteoarthritis (HP:0002758)1.72211250
133Insulin resistance (HP:0000855)1.72062913
134Protuberant abdomen (HP:0001538)1.71568489
135Deep venous thrombosis (HP:0002625)1.71274032
136Spontaneous hematomas (HP:0007420)1.71052388
137Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70759223
138Chronic otitis media (HP:0000389)1.70421976
139Coxa vara (HP:0002812)1.70164523
140Increased variability in muscle fiber diameter (HP:0003557)1.69730903
141Abnormality of purine metabolism (HP:0004352)1.69631460
142Genetic anticipation (HP:0003743)1.69600709
143Asymmetry of the thorax (HP:0001555)1.69597236
144Prolonged bleeding time (HP:0003010)1.69521067
145Abnormality of carpal bone ossification (HP:0006257)1.69386921
146Increased IgE level (HP:0003212)1.69269353
147Ulnar deviation of the wrist (HP:0003049)1.68949033
148Rectal prolapse (HP:0002035)1.68859754
149Abnormality of skeletal muscle fiber size (HP:0012084)1.67608724
150Cerebral inclusion bodies (HP:0100314)1.67441121
151Abnormality of glutamine family amino acid metabolism (HP:0010902)1.67365392
152Disinhibition (HP:0000734)1.67143125
153Joint hemorrhage (HP:0005261)1.66790231
154Aortic valve stenosis (HP:0001650)1.66730408
155Atelectasis (HP:0100750)1.66421862
156Coarse hair (HP:0002208)1.64665573
157Hypercortisolism (HP:0001578)1.63471544
158Hypoplasia of the odontoid process (HP:0003311)1.63162241
159Delayed closure of the anterior fontanelle (HP:0001476)1.62931981
160Cupped ribs (HP:0000887)1.61739766
161Abnormality of the radial head (HP:0003995)1.61410285
162Biconcave vertebral bodies (HP:0004586)1.61344060
163Epistaxis (HP:0000421)1.60700299
164Abnormality of dentin (HP:0010299)1.59720197
165Abnormality of the common coagulation pathway (HP:0010990)1.55806231
166Postural tremor (HP:0002174)1.55644114
167Segmental peripheral demyelination/remyelination (HP:0003481)1.54231280

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.31693965
2PKN23.57843563
3ERN13.53463179
4TAOK22.80030624
5PDK32.58310287
6PDK42.58310287
7EEF2K2.36491005
8CAMK1D2.29778197
9MST1R2.26435849
10MKNK22.19970420
11PRPF4B2.18586591
12MAP3K112.04844876
13RIPK12.01150345
14SIK11.97572853
15MAP3K101.85281131
16PRKD31.83393808
17TTN1.80732372
18TESK11.80127918
19CAMK1G1.72695668
20EPHB11.66178546
21FGFR41.63666203
22PTK61.59917606
23PDK21.56083533
24ICK1.56042619
25PRKD21.53605764
26KSR21.49509642
27TGFBR21.49497114
28PDGFRA1.46032476
29LRRK21.44815594
30EPHA31.42246851
31CDC42BPA1.40777778
32MAP4K11.37319010
33WNK11.35275328
34BCKDK1.29429204
35MAP3K21.27663355
36TBK11.24734469
37MARK21.23492929
38FGFR31.22823754
39FLT31.19807523
40JAK11.19596933
41AKT31.16076962
42SCYL21.15621152
43TRPM71.13273013
44FRK1.12148255
45HIPK21.10585454
46NTRK11.09462928
47TYK21.08525226
48ZAP701.07608250
49ABL21.04050444
50RET1.02932516
51LATS11.02430148
52NEK91.02373458
53STK31.02069370
54BMX0.99416753
55JAK30.98237797
56PDK10.94926753
57TYRO30.94679249
58MAP2K30.93359207
59PDPK10.90686462
60RIPK40.90443627
61MYLK0.90043875
62JAK20.89483900
63TAOK10.88957200
64RPS6KA40.87557461
65MAP3K30.84159820
66LATS20.83275002
67PAK40.82679249
68SMG10.82580687
69WNK40.82562061
70MET0.80885217
71MTOR0.79581134
72IRAK30.77862948
73MAP3K130.77854644
74PTK2B0.76607190
75PDGFRB0.76604720
76CAMKK10.76440907
77CDK60.76007569
78MAP3K50.75261166
79RPS6KA20.74592305
80DDR20.74341458
81MAP3K60.73600607
82MAP2K10.71351932
83STK100.71041263
84DMPK0.70940514
85SGK30.70016202
86KIT0.69585658
87MAP3K10.68352073
88MAPK70.66986535
89DYRK1B0.66686217
90PAK20.66436258
91MAP2K20.65018638
92CDK120.64998934
93MELK0.64761934
94PRKAA20.63952735
95STK380.63711289
96FGFR20.62441083
97MAPKAPK30.60231818
98PTK20.59836910
99CSK0.58769207
100TAOK30.57572120
101MAPK120.56810568
102CDK40.56350615
103LMTK20.56341165
104HCK0.56291399
105CSF1R0.55925120
106PRKCH0.54839359
107SIK20.54267481
108DAPK20.53441450
109ILK0.53151858
110IRAK10.52729907
111NEK20.51545260
112PIM10.51378713
113PIK3CA0.50170540
114BLK0.50159239
115DYRK1A0.49971668
116CDK90.48973003
117ALK0.47591350
118TNK20.47507524
119BTK0.46990777
120NTRK30.46876104
121GRK60.45501714
122IKBKE0.43162679
123MAP3K70.42947212
124YES10.42932812
125PRKG20.42612530
126MAPK110.41549035
127MAP3K80.40746915
128KDR0.40710994
129CDK190.38856591
130RPS6KC10.38412452
131RPS6KL10.38412452
132EPHA20.37293269
133FGR0.37185121
134CHUK0.36431268
135PRKD10.35644068
136MKNK10.35543404
137PRKAA10.34916873
138MAP3K140.34544847
139PAK60.34343837
140ITK0.32139107

Predicted pathways (KEGG)

RankGene SetZ-score
1PPAR signaling pathway_Homo sapiens_hsa033202.63807726
2Fatty acid biosynthesis_Homo sapiens_hsa000612.56516433
3Fatty acid degradation_Homo sapiens_hsa000712.30191683
4Propanoate metabolism_Homo sapiens_hsa006402.20468703
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.18452133
6Fatty acid metabolism_Homo sapiens_hsa012122.06292911
7Adipocytokine signaling pathway_Homo sapiens_hsa049201.84366570
8Glycerolipid metabolism_Homo sapiens_hsa005611.75059384
9Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.73966813
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64698966
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.60719059
12Nitrogen metabolism_Homo sapiens_hsa009101.59609412
13Insulin resistance_Homo sapiens_hsa049311.58138058
14Caffeine metabolism_Homo sapiens_hsa002321.57674037
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57156002
16Fat digestion and absorption_Homo sapiens_hsa049751.57026457
17Staphylococcus aureus infection_Homo sapiens_hsa051501.47532925
18Lysosome_Homo sapiens_hsa041421.39874986
19Osteoclast differentiation_Homo sapiens_hsa043801.38368249
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.37217754
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.35368799
22Carbon metabolism_Homo sapiens_hsa012001.31313279
23B cell receptor signaling pathway_Homo sapiens_hsa046621.26512129
24Leishmaniasis_Homo sapiens_hsa051401.25988769
25Phospholipase D signaling pathway_Homo sapiens_hsa040721.25192470
26Toxoplasmosis_Homo sapiens_hsa051451.19950359
27Chronic myeloid leukemia_Homo sapiens_hsa052201.16593931
28Pyruvate metabolism_Homo sapiens_hsa006201.16560997
29AMPK signaling pathway_Homo sapiens_hsa041521.14838059
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14807447
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14720642
32Renal cell carcinoma_Homo sapiens_hsa052111.13450558
33GnRH signaling pathway_Homo sapiens_hsa049121.11995112
34Choline metabolism in cancer_Homo sapiens_hsa052311.09992845
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.09638138
36Acute myeloid leukemia_Homo sapiens_hsa052211.09357105
37mTOR signaling pathway_Homo sapiens_hsa041501.09108644
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08805433
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.05897719
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04558941
41Notch signaling pathway_Homo sapiens_hsa043301.02366526
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01991342
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00914778
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00884675
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00467519
46Pentose phosphate pathway_Homo sapiens_hsa000300.98808618
47Focal adhesion_Homo sapiens_hsa045100.95553977
48Hepatitis C_Homo sapiens_hsa051600.95001554
49Insulin signaling pathway_Homo sapiens_hsa049100.94720592
50Antigen processing and presentation_Homo sapiens_hsa046120.93327182
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93319870
52Legionellosis_Homo sapiens_hsa051340.92668955
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91720077
54Glucagon signaling pathway_Homo sapiens_hsa049220.90909186
55VEGF signaling pathway_Homo sapiens_hsa043700.90392182
56Prion diseases_Homo sapiens_hsa050200.90382750
57ErbB signaling pathway_Homo sapiens_hsa040120.90090117
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89756258
59Amoebiasis_Homo sapiens_hsa051460.89459822
60Protein digestion and absorption_Homo sapiens_hsa049740.89447097
61Endometrial cancer_Homo sapiens_hsa052130.88804177
62Tuberculosis_Homo sapiens_hsa051520.88616754
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87599395
64Proteoglycans in cancer_Homo sapiens_hsa052050.86023629
65Pancreatic cancer_Homo sapiens_hsa052120.85197696
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84616204
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84490948
68ECM-receptor interaction_Homo sapiens_hsa045120.84218243
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84011926
70Platelet activation_Homo sapiens_hsa046110.83758871
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.83262527
72HIF-1 signaling pathway_Homo sapiens_hsa040660.83071424
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82592531
74FoxO signaling pathway_Homo sapiens_hsa040680.81678978
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.81518595
76Small cell lung cancer_Homo sapiens_hsa052220.80458899
77Prostate cancer_Homo sapiens_hsa052150.80206258
78Complement and coagulation cascades_Homo sapiens_hsa046100.80025444
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79563364
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78635224
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77804397
82Estrogen signaling pathway_Homo sapiens_hsa049150.76908118
83MicroRNAs in cancer_Homo sapiens_hsa052060.75860578
84Thyroid hormone synthesis_Homo sapiens_hsa049180.75254707
85Bile secretion_Homo sapiens_hsa049760.73878571
86Inositol phosphate metabolism_Homo sapiens_hsa005620.73550094
87Lysine degradation_Homo sapiens_hsa003100.73501935
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73419908
89Type II diabetes mellitus_Homo sapiens_hsa049300.73139928
90Starch and sucrose metabolism_Homo sapiens_hsa005000.72087008
91MAPK signaling pathway_Homo sapiens_hsa040100.71544023
92Selenocompound metabolism_Homo sapiens_hsa004500.71492936
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71267918
94Rap1 signaling pathway_Homo sapiens_hsa040150.71017305
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70640782
96Dorso-ventral axis formation_Homo sapiens_hsa043200.70560571
97Sphingolipid metabolism_Homo sapiens_hsa006000.70069848
98Other glycan degradation_Homo sapiens_hsa005110.69067479
99Arginine biosynthesis_Homo sapiens_hsa002200.67974674
100Adherens junction_Homo sapiens_hsa045200.67166170
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66913851
102TNF signaling pathway_Homo sapiens_hsa046680.66456393
103T cell receptor signaling pathway_Homo sapiens_hsa046600.66395010
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.66392565
105Hepatitis B_Homo sapiens_hsa051610.66300663
106Bladder cancer_Homo sapiens_hsa052190.65250185
107Pertussis_Homo sapiens_hsa051330.65175614
108Tryptophan metabolism_Homo sapiens_hsa003800.64845519
109Non-small cell lung cancer_Homo sapiens_hsa052230.64659078
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64656818
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64380607
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63686994
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.63492586
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63491045
115Circadian rhythm_Homo sapiens_hsa047100.63394544
116Galactose metabolism_Homo sapiens_hsa000520.63183761
117Malaria_Homo sapiens_hsa051440.62407873
118Apoptosis_Homo sapiens_hsa042100.61548915
119beta-Alanine metabolism_Homo sapiens_hsa004100.61083072
120Viral myocarditis_Homo sapiens_hsa054160.60861740
121Melanoma_Homo sapiens_hsa052180.59023103
122Prolactin signaling pathway_Homo sapiens_hsa049170.58748415
123Chemokine signaling pathway_Homo sapiens_hsa040620.58176751
124Dilated cardiomyopathy_Homo sapiens_hsa054140.57850615
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.57731740
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.57436759
127Ras signaling pathway_Homo sapiens_hsa040140.57203314
128Fructose and mannose metabolism_Homo sapiens_hsa000510.56967223
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.55951807
130Renin-angiotensin system_Homo sapiens_hsa046140.55698929
131Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55514398
132Endocytosis_Homo sapiens_hsa041440.55378250
133Influenza A_Homo sapiens_hsa051640.55333672
134ABC transporters_Homo sapiens_hsa020100.55175985
135Shigellosis_Homo sapiens_hsa051310.54534445
136Mineral absorption_Homo sapiens_hsa049780.54097877
137African trypanosomiasis_Homo sapiens_hsa051430.53954879
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.52891428
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52649954
140Long-term potentiation_Homo sapiens_hsa047200.52623515
141Peroxisome_Homo sapiens_hsa041460.52250611
142Measles_Homo sapiens_hsa051620.51656256
143Biosynthesis of amino acids_Homo sapiens_hsa012300.50005099
144Glioma_Homo sapiens_hsa052140.49931958

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