TBC1D19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)4.97170275
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.90727189
3cilium movement (GO:0003341)4.78554783
4positive regulation of mitochondrial fission (GO:0090141)4.67504938
5cilium or flagellum-dependent cell motility (GO:0001539)4.53829290
6axon ensheathment in central nervous system (GO:0032291)3.92781212
7central nervous system myelination (GO:0022010)3.92781212
8neuron cell-cell adhesion (GO:0007158)3.81080310
9synaptic vesicle exocytosis (GO:0016079)3.74271475
10cilium organization (GO:0044782)3.72329619
11axonemal dynein complex assembly (GO:0070286)3.70793743
12cilium assembly (GO:0042384)3.65775419
13neuronal action potential propagation (GO:0019227)3.64940505
14regulation of cilium movement (GO:0003352)3.63218191
15presynaptic membrane assembly (GO:0097105)3.53205327
16DNA integration (GO:0015074)3.43541923
17pyrimidine nucleobase catabolic process (GO:0006208)3.43258669
18intraciliary transport (GO:0042073)3.41620505
19regulation of synaptic vesicle exocytosis (GO:2000300)3.39548694
20chaperone-mediated protein transport (GO:0072321)3.37042021
21synaptic vesicle maturation (GO:0016188)3.33401161
22cullin deneddylation (GO:0010388)3.26568150
23left/right axis specification (GO:0070986)3.24897398
24presynaptic membrane organization (GO:0097090)3.22089825
25glutamate secretion (GO:0014047)3.20631730
26platelet dense granule organization (GO:0060155)3.14714858
27microtubule depolymerization (GO:0007019)3.13282720
28protein deneddylation (GO:0000338)3.12077349
29postsynaptic membrane organization (GO:0001941)3.09136306
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.08073047
31protein localization to synapse (GO:0035418)3.06629672
32regulation of synaptic vesicle transport (GO:1902803)3.02532227
33negative regulation of neurotransmitter transport (GO:0051589)3.01831888
34neural tube formation (GO:0001841)2.99696274
35neurofilament cytoskeleton organization (GO:0060052)2.98653227
36cerebral cortex radially oriented cell migration (GO:0021799)2.98256088
37negative regulation of homotypic cell-cell adhesion (GO:0034111)2.94730612
38nucleobase catabolic process (GO:0046113)2.92906388
39positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.92106289
40behavioral response to ethanol (GO:0048149)2.91385569
41cellular component assembly involved in morphogenesis (GO:0010927)2.91079996
42retinal rod cell development (GO:0046548)2.87474297
43neuron recognition (GO:0008038)2.86503230
44axonal fasciculation (GO:0007413)2.86394635
45eye photoreceptor cell differentiation (GO:0001754)2.86196731
46photoreceptor cell differentiation (GO:0046530)2.86196731
47apical protein localization (GO:0045176)2.86122144
48preassembly of GPI anchor in ER membrane (GO:0016254)2.83755573
49regulation of mitochondrial fission (GO:0090140)2.81994176
50negative regulation of cytosolic calcium ion concentration (GO:0051481)2.81978079
51retinal cone cell development (GO:0046549)2.78578141
52negative regulation of axon guidance (GO:1902668)2.76921490
53regulation of short-term neuronal synaptic plasticity (GO:0048172)2.76501199
54establishment of mitochondrion localization (GO:0051654)2.75054165
55synaptic vesicle endocytosis (GO:0048488)2.74967093
56spermatid nucleus differentiation (GO:0007289)2.73789453
57negative regulation of neurotransmitter secretion (GO:0046929)2.72539839
58protein polyglutamylation (GO:0018095)2.69691361
59fatty acid elongation (GO:0030497)2.68865867
60innervation (GO:0060384)2.68712460
61positive regulation of steroid hormone secretion (GO:2000833)2.67129610
62detection of calcium ion (GO:0005513)2.66850767
63anterograde synaptic vesicle transport (GO:0048490)2.65480376
64regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.65443529
65synaptic vesicle docking involved in exocytosis (GO:0016081)2.62675727
66inositol phosphate catabolic process (GO:0071545)2.62674512
67respiratory chain complex IV assembly (GO:0008535)2.62662388
68retinal ganglion cell axon guidance (GO:0031290)2.62355425
69water-soluble vitamin biosynthetic process (GO:0042364)2.62024862
70protein complex biogenesis (GO:0070271)2.61147643
71protein localization to cilium (GO:0061512)2.60293864
72sequestering of actin monomers (GO:0042989)2.59895905
73synaptic vesicle transport (GO:0048489)2.58863133
74establishment of synaptic vesicle localization (GO:0097480)2.58863133
75determination of left/right symmetry (GO:0007368)2.58490090
76regulation of corticosteroid hormone secretion (GO:2000846)2.58296985
77photoreceptor cell maintenance (GO:0045494)2.57576991
78C-terminal protein lipidation (GO:0006501)2.57338077
79limb bud formation (GO:0060174)2.56942041
80inositol phosphate dephosphorylation (GO:0046855)2.55943400
81phosphorylated carbohydrate dephosphorylation (GO:0046838)2.55943400
82determination of bilateral symmetry (GO:0009855)2.54615519
83response to auditory stimulus (GO:0010996)2.53426518
84left/right pattern formation (GO:0060972)2.53012854
85regulation of vesicle fusion (GO:0031338)2.52903262
86behavioral response to nicotine (GO:0035095)2.52297936
87positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.52062700
88proteasome assembly (GO:0043248)2.51700655
89synaptic transmission, glutamatergic (GO:0035249)2.50125968
90calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.49523114
91specification of symmetry (GO:0009799)2.49423981
92protein neddylation (GO:0045116)2.49110886
93anterograde axon cargo transport (GO:0008089)2.48891356
94regulation of hexokinase activity (GO:1903299)2.48863078
95regulation of glucokinase activity (GO:0033131)2.48863078
96dendrite morphogenesis (GO:0048813)2.48231119
97asymmetric protein localization (GO:0008105)2.48095429
98long-chain fatty acid biosynthetic process (GO:0042759)2.47513506
99substantia nigra development (GO:0021762)2.47325183
100regulation of action potential (GO:0098900)2.47215332
101C-terminal protein amino acid modification (GO:0018410)2.45622302
102axoneme assembly (GO:0035082)2.45524276
103type B pancreatic cell proliferation (GO:0044342)2.44290912
104negative regulation of dendrite morphogenesis (GO:0050774)2.43402508
105G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.42507425
106mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.42397194
107positive regulation of action potential (GO:0045760)2.42226923
108glutamate receptor signaling pathway (GO:0007215)2.42129920
109mitochondrial respiratory chain complex assembly (GO:0033108)2.42082763
110regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.41845177
111establishment of vesicle localization (GO:0051650)2.41561154
112microtubule-based movement (GO:0007018)2.41336303
113neuron-neuron synaptic transmission (GO:0007270)2.40888122
114vocalization behavior (GO:0071625)2.40527780
115regulation of amyloid precursor protein catabolic process (GO:1902991)2.39857033
116vascular smooth muscle contraction (GO:0014829)2.39606259
117cilium morphogenesis (GO:0060271)2.38982183
118negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.38808012
119negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.38761708
120protein localization to Golgi apparatus (GO:0034067)2.38317318
121transmission of nerve impulse (GO:0019226)2.38257770
122regulation of feeding behavior (GO:0060259)2.38109963
123smoothened signaling pathway (GO:0007224)2.38004038
124ventricular system development (GO:0021591)2.37277373
125negative regulation of neurological system process (GO:0031645)2.36134934
126establishment of protein localization to Golgi (GO:0072600)2.35683081
127regulation of chronic inflammatory response (GO:0002676)2.35633753
128sperm motility (GO:0030317)2.35258305
129microtubule bundle formation (GO:0001578)2.35061855
130dendrite development (GO:0016358)2.34661400
131regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.34457614
132cytochrome complex assembly (GO:0017004)2.34087357
133mannosylation (GO:0097502)2.33687981
134regulation of neurotransmitter secretion (GO:0046928)2.33670192
135regulation of neuronal synaptic plasticity (GO:0048168)2.33110463
136negative chemotaxis (GO:0050919)2.32996534
137neurotransmitter uptake (GO:0001504)2.32713569
138regulation of voltage-gated calcium channel activity (GO:1901385)2.32702232
139nonmotile primary cilium assembly (GO:0035058)2.32201594
140calcium-mediated signaling using intracellular calcium source (GO:0035584)2.32141595
141regulation of catecholamine metabolic process (GO:0042069)2.31938854
142regulation of dopamine metabolic process (GO:0042053)2.31938854
143neurotransmitter-gated ion channel clustering (GO:0072578)2.31789470
144mechanosensory behavior (GO:0007638)2.30983923
145regulation of Golgi to plasma membrane protein transport (GO:0042996)2.30319271
146auditory behavior (GO:0031223)2.30179311
147regulation of glycogen (starch) synthase activity (GO:2000465)2.29689023
148negative regulation of synaptic transmission, GABAergic (GO:0032229)2.29294538
149microtubule-based transport (GO:0010970)2.28101241
150response to pheromone (GO:0019236)2.27937983
151neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.27671993
152regulation of synaptic transmission, glutamatergic (GO:0051966)2.27268971
153intra-Golgi vesicle-mediated transport (GO:0006891)2.27176557
154regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.27153596
155brain morphogenesis (GO:0048854)2.26714304
156Golgi to plasma membrane protein transport (GO:0043001)2.26565876
157ubiquinone metabolic process (GO:0006743)2.26107902
158rRNA methylation (GO:0031167)2.25647372
159long-term synaptic potentiation (GO:0060291)2.25569827
160microtubule severing (GO:0051013)2.25550388
161negative regulation of cation channel activity (GO:2001258)2.24907137
162keratinocyte development (GO:0003334)2.24270025
163regulation of axon regeneration (GO:0048679)2.24224279
164regulation of neuron projection regeneration (GO:0070570)2.24224279
165myelination (GO:0042552)2.24013852
166gamma-aminobutyric acid transport (GO:0015812)2.23717775
167regulation of neurotransmitter transport (GO:0051588)2.23397321
168regulation of synapse structural plasticity (GO:0051823)2.23222675
169negative regulation of dendrite development (GO:2000171)2.22974006
170regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.22725846
171regulation of protein targeting to membrane (GO:0090313)2.22611144
172fibroblast migration (GO:0010761)2.22027595
173positive regulation of synapse assembly (GO:0051965)2.21956247
174protein targeting to Golgi (GO:0000042)2.20924713
175neurotransmitter secretion (GO:0007269)2.20467155
176synapse assembly (GO:0007416)2.20037685
177negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.19721830
178establishment of nucleus localization (GO:0040023)2.19448867
179positive regulation of synaptic transmission, GABAergic (GO:0032230)2.19416552
180GPI anchor metabolic process (GO:0006505)2.18486301
181retrograde transport, vesicle recycling within Golgi (GO:0000301)2.18193885
182negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.17765807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.51469894
2GBX2_23144817_ChIP-Seq_PC3_Human4.28441862
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.04869129
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.82923467
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.54519707
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45598695
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32608736
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27147200
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26509678
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.13318743
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11438282
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.08700658
13TAF15_26573619_Chip-Seq_HEK293_Human2.05787331
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02116619
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.01055693
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.00693435
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98972714
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98849061
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97709051
20SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.95839954
21P300_19829295_ChIP-Seq_ESCs_Human1.91071580
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90502758
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90502758
24OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.90497391
25* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89580231
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85968124
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.85934632
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85864765
29IGF1R_20145208_ChIP-Seq_DFB_Human1.85485927
30FUS_26573619_Chip-Seq_HEK293_Human1.80505545
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.79049260
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78892905
33* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77572109
34SMAD4_21799915_ChIP-Seq_A2780_Human1.77166846
35* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76121776
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75602991
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72667999
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71425604
39REST_21632747_ChIP-Seq_MESCs_Mouse1.70080840
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69145766
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.68713932
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.67014951
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.65959901
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.64752440
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64599181
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58045140
47ELK1_19687146_ChIP-ChIP_HELA_Human1.54258663
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48059222
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.47254568
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47237729
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.45636873
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44909117
53STAT3_23295773_ChIP-Seq_U87_Human1.44675017
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44654406
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43463051
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43202460
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43051655
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41746665
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.40589904
60RNF2_27304074_Chip-Seq_NSC_Mouse1.40246691
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38108012
62ZNF274_21170338_ChIP-Seq_K562_Hela1.37581961
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37481788
64* REST_18959480_ChIP-ChIP_MESCs_Mouse1.37463600
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36466377
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33919888
67AR_21572438_ChIP-Seq_LNCaP_Human1.33241734
68ER_23166858_ChIP-Seq_MCF-7_Human1.33204148
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.32024217
70* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31466597
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29318054
72BCAT_22108803_ChIP-Seq_LS180_Human1.28964965
73AR_25329375_ChIP-Seq_VCAP_Human1.28500283
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27214114
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26743088
76EST1_17652178_ChIP-ChIP_JURKAT_Human1.26443991
77RARB_27405468_Chip-Seq_BRAIN_Mouse1.26081942
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.25438622
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25019103
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24721676
81VDR_22108803_ChIP-Seq_LS180_Human1.23613990
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23104866
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22733531
84TP53_22573176_ChIP-Seq_HFKS_Human1.20031316
85DROSHA_22980978_ChIP-Seq_HELA_Human1.19490446
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.19373781
87* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.18981990
88* TCF4_23295773_ChIP-Seq_U87_Human1.18653687
89* TCF4_22108803_ChIP-Seq_LS180_Human1.18419109
90IRF1_19129219_ChIP-ChIP_H3396_Human1.17726811
91RUNX2_22187159_ChIP-Seq_PCA_Human1.17515139
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16777400
93EWS_26573619_Chip-Seq_HEK293_Human1.16599806
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15907586
95SOX2_19829295_ChIP-Seq_ESCs_Human1.15876363
96NANOG_19829295_ChIP-Seq_ESCs_Human1.15876363
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13834209
98P53_22387025_ChIP-Seq_ESCs_Mouse1.13634206
99JUN_21703547_ChIP-Seq_K562_Human1.13357937
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12910043
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.12351287
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.12233671
103* SOX2_21211035_ChIP-Seq_LN229_Gbm1.11390674
104TP53_16413492_ChIP-PET_HCT116_Human1.11313106
105PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11224610
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11215931
107CRX_20693478_ChIP-Seq_RETINA_Mouse1.11044173
108CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10739624
109CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.10157633
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.09141885
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.08929284
112STAT3_18555785_Chip-Seq_ESCs_Mouse1.08396818
113CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07661739
114EP300_21415370_ChIP-Seq_HL-1_Mouse1.07545574
115PRDM14_20953172_ChIP-Seq_ESCs_Human1.07324591
116SOX9_26525672_Chip-Seq_HEART_Mouse1.07217789
117TAL1_26923725_Chip-Seq_HPCs_Mouse1.06822337
118TP53_18474530_ChIP-ChIP_U2OS_Human1.06287770
119SMAD_19615063_ChIP-ChIP_OVARY_Human1.06038902
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05914296
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05012731
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04832433
123SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04584161
124AHR_22903824_ChIP-Seq_MCF-7_Human1.04257022
125POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02801165
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02727361
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02351962
128FLI1_27457419_Chip-Seq_LIVER_Mouse1.02033231
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01704224
130* VDR_23849224_ChIP-Seq_CD4+_Human1.01575614
131SOX2_18555785_Chip-Seq_ESCs_Mouse1.01510275
132MYC_18940864_ChIP-ChIP_HL60_Human1.00475349
133NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00260160
134NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00260160
135* CJUN_26792858_Chip-Seq_BT549_Human1.00195898
136IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00098643
137CBP_20019798_ChIP-Seq_JUKART_Human1.00098643

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.92100298
2MP0004270_analgesia3.37587442
3MP0004859_abnormal_synaptic_plasticity3.28847120
4MP0000569_abnormal_digit_pigmentation3.23515917
5MP0005646_abnormal_pituitary_gland2.86430235
6MP0003635_abnormal_synaptic_transmissio2.49422175
7MP0001986_abnormal_taste_sensitivity2.36525742
8MP0002734_abnormal_mechanical_nocicepti2.27966287
9MP0001968_abnormal_touch/_nociception2.27742268
10MP0006276_abnormal_autonomic_nervous2.26324162
11MP0002735_abnormal_chemical_nociception2.23467929
12MP0009780_abnormal_chondrocyte_physiolo2.22345492
13MP0010386_abnormal_urinary_bladder2.18499443
14MP0000778_abnormal_nervous_system2.13095497
15MP0002064_seizures2.09812621
16MP0002063_abnormal_learning/memory/cond2.06855854
17MP0002234_abnormal_pharynx_morphology2.06501290
18MP0009745_abnormal_behavioral_response2.04249157
19MP0002272_abnormal_nervous_system2.00688480
20MP0002572_abnormal_emotion/affect_behav2.00673876
21MP0002736_abnormal_nociception_after1.99608370
22MP0002102_abnormal_ear_morphology1.98131000
23MP0001905_abnormal_dopamine_level1.96904429
24MP0003122_maternal_imprinting1.86696846
25MP0005187_abnormal_penis_morphology1.86038525
26MP0008877_abnormal_DNA_methylation1.86000945
27MP0005423_abnormal_somatic_nervous1.84598432
28MP0009046_muscle_twitch1.81575168
29MP0001486_abnormal_startle_reflex1.81152087
30MP0002733_abnormal_thermal_nociception1.80756392
31MP0004043_abnormal_pH_regulation1.79977594
32MP0006054_spinal_hemorrhage1.78054775
33MP0004858_abnormal_nervous_system1.77387447
34MP0001529_abnormal_vocalization1.77060897
35MP0002653_abnormal_ependyma_morphology1.76218327
36MP0002638_abnormal_pupillary_reflex1.67402697
37MP0001970_abnormal_pain_threshold1.67047973
38MP0001440_abnormal_grooming_behavior1.65125649
39MP0002822_catalepsy1.64669247
40MP0001188_hyperpigmentation1.64158363
41MP0000013_abnormal_adipose_tissue1.64126029
42MP0005171_absent_coat_pigmentation1.63352869
43MP0002067_abnormal_sensory_capabilities1.63034445
44MP0005645_abnormal_hypothalamus_physiol1.60916241
45MP0006292_abnormal_olfactory_placode1.60137087
46MP0002557_abnormal_social/conspecific_i1.52114222
47MP0005379_endocrine/exocrine_gland_phen1.51106429
48MP0001502_abnormal_circadian_rhythm1.48846346
49MP0006072_abnormal_retinal_apoptosis1.46300596
50MP0005551_abnormal_eye_electrophysiolog1.45683587
51MP0000427_abnormal_hair_cycle1.43257972
52MP0000955_abnormal_spinal_cord1.42866777
53MP0002184_abnormal_innervation1.42862703
54MP0002282_abnormal_trachea_morphology1.42343143
55MP0004133_heterotaxia1.42338188
56MP0000631_abnormal_neuroendocrine_gland1.42149550
57MP0004145_abnormal_muscle_electrophysio1.41338456
58MP0002882_abnormal_neuron_morphology1.39741563
59MP0003329_amyloid_beta_deposits1.38871743
60MP0000920_abnormal_myelination1.37101895
61MP0001984_abnormal_olfaction1.34191590
62MP0002938_white_spotting1.34095093
63MP0000647_abnormal_sebaceous_gland1.31193882
64MP0002928_abnormal_bile_duct1.30823568
65MP0003634_abnormal_glial_cell1.29274208
66MP0004142_abnormal_muscle_tone1.27082589
67MP0005253_abnormal_eye_physiology1.26575832
68MP0008569_lethality_at_weaning1.26483747
69MP0002233_abnormal_nose_morphology1.25713243
70MP0000372_irregular_coat_pigmentation1.25368241
71MP0008789_abnormal_olfactory_epithelium1.24579278
72MP0001299_abnormal_eye_distance/1.24112322
73MP0001485_abnormal_pinna_reflex1.23631226
74MP0004924_abnormal_behavior1.23366026
75MP0005386_behavior/neurological_phenoty1.23366026
76MP0002163_abnormal_gland_morphology1.23251784
77MP0005623_abnormal_meninges_morphology1.23035713
78MP0002160_abnormal_reproductive_system1.21953771
79MP0004215_abnormal_myocardial_fiber1.19813180
80MP0008438_abnormal_cutaneous_collagen1.19397022
81MP0004885_abnormal_endolymph1.18629179
82MP0001348_abnormal_lacrimal_gland1.16720113
83MP0001501_abnormal_sleep_pattern1.16454853
84MP0004811_abnormal_neuron_physiology1.16078401
85MP0008058_abnormal_DNA_repair1.16028586
86MP0002229_neurodegeneration1.13430192
87MP0002066_abnormal_motor_capabilities/c1.12196561
88MP0002909_abnormal_adrenal_gland1.11240752
89MP0003937_abnormal_limbs/digits/tail_de1.09925885
90MP0008995_early_reproductive_senescence1.08112007
91MP0001293_anophthalmia1.06512468
92MP0002752_abnormal_somatic_nervous1.04575237
93MP0000516_abnormal_urinary_system1.03098769
94MP0005367_renal/urinary_system_phenotyp1.03098769
95MP0004147_increased_porphyrin_level1.02957532
96MP0002751_abnormal_autonomic_nervous1.01935523
97MP0000639_abnormal_adrenal_gland1.00030949
98MP0003186_abnormal_redox_activity0.99718032
99MP0002152_abnormal_brain_morphology0.98470367
100MP0005409_darkened_coat_color0.96825282
101MP0000534_abnormal_ureter_morphology0.95968055
102MP0005391_vision/eye_phenotype0.95646791
103MP0005394_taste/olfaction_phenotype0.95553660
104MP0005499_abnormal_olfactory_system0.95553660
105MP0002090_abnormal_vision0.95432388
106MP0003950_abnormal_plasma_membrane0.95063955
107MP0002876_abnormal_thyroid_physiology0.94245387
108MP0002295_abnormal_pulmonary_circulatio0.93558125
109MP0003633_abnormal_nervous_system0.92137283
110MP0000681_abnormal_thyroid_gland0.91830493
111MP0001963_abnormal_hearing_physiology0.91764230
112MP0004484_altered_response_of0.89660191
113MP0003195_calcinosis0.88481696
114MP0005503_abnormal_tendon_morphology0.87634422
115MP0000751_myopathy0.87555126
116MP0003879_abnormal_hair_cell0.87131398
117MP0003787_abnormal_imprinting0.86987824
118MP0003755_abnormal_palate_morphology0.86493689
119MP0009697_abnormal_copulation0.86452460
120MP0003631_nervous_system_phenotype0.85466427
121MP0001177_atelectasis0.85314846
122MP0005084_abnormal_gallbladder_morpholo0.85271562
123MP0009250_abnormal_appendicular_skeleto0.84856079
124MP0004742_abnormal_vestibular_system0.84679432
125MP0005174_abnormal_tail_pigmentation0.81534154
126MP0003136_yellow_coat_color0.81062529
127MP0003011_delayed_dark_adaptation0.77859271
128MP0003942_abnormal_urinary_system0.77578337
129MP0005389_reproductive_system_phenotype0.77522108
130MP0001324_abnormal_eye_pigmentation0.77340043
131MP0002837_dystrophic_cardiac_calcinosis0.76706111
132MP0000026_abnormal_inner_ear0.76344490
133MP0001664_abnormal_digestion0.76192068
134MP0003121_genomic_imprinting0.76013128
135MP0000749_muscle_degeneration0.75586362
136MP0001958_emphysema0.72696233
137MP0003632_abnormal_nervous_system0.71454224
138MP0000538_abnormal_urinary_bladder0.70523071
139MP0003137_abnormal_impulse_conducting0.68568849
140MP0004134_abnormal_chest_morphology0.68121180
141MP0005410_abnormal_fertilization0.68117261
142MP0005195_abnormal_posterior_eye0.67688268
143MP0000049_abnormal_middle_ear0.66735185
144MP0003690_abnormal_glial_cell0.66340343

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.14621447
2Chronic hepatic failure (HP:0100626)3.97066988
3Focal motor seizures (HP:0011153)3.92017400
4Pheochromocytoma (HP:0002666)3.79685277
5Neuroendocrine neoplasm (HP:0100634)3.40535044
6Epileptic encephalopathy (HP:0200134)3.36940167
7Atonic seizures (HP:0010819)3.36488291
8Medial flaring of the eyebrow (HP:0010747)3.35448328
9Hypothermia (HP:0002045)3.30943809
10Gait imbalance (HP:0002141)3.16941374
11Occipital encephalocele (HP:0002085)3.11319504
12Abnormality of the renal medulla (HP:0100957)3.09504009
13Vaginal atresia (HP:0000148)3.00691967
14Congenital primary aphakia (HP:0007707)2.99743046
15Genital tract atresia (HP:0001827)2.97356370
16Myokymia (HP:0002411)2.97296323
17Rhinitis (HP:0012384)2.92509593
18Aplasia/Hypoplasia of the tongue (HP:0010295)2.88403282
19Nephrogenic diabetes insipidus (HP:0009806)2.88197816
20Focal seizures (HP:0007359)2.76396995
21Cystic liver disease (HP:0006706)2.66334762
22Neurofibrillary tangles (HP:0002185)2.59948870
23Abnormality of the renal cortex (HP:0011035)2.55857237
24Progressive cerebellar ataxia (HP:0002073)2.55372765
25Megalencephaly (HP:0001355)2.49648669
26Absence seizures (HP:0002121)2.47207205
27Postaxial foot polydactyly (HP:0001830)2.46846177
28Aplasia/Hypoplasia of the tibia (HP:0005772)2.45669060
29Keratoconus (HP:0000563)2.43439008
30Increased corneal curvature (HP:0100692)2.43439008
31Retinal dysplasia (HP:0007973)2.40973230
32Short tibia (HP:0005736)2.40651475
33Acute necrotizing encephalopathy (HP:0006965)2.37199033
34Hepatocellular necrosis (HP:0001404)2.36525301
35Bifid tongue (HP:0010297)2.36191430
36Abnormal hair whorl (HP:0010721)2.35439280
37Tubulointerstitial abnormality (HP:0001969)2.35167205
38Aplasia involving bones of the upper limbs (HP:0009823)2.33965655
39Aplasia of the phalanges of the hand (HP:0009802)2.33965655
40Aplasia involving bones of the extremities (HP:0009825)2.33965655
41Tubulointerstitial nephritis (HP:0001970)2.33593696
42Febrile seizures (HP:0002373)2.31637069
43Dialeptic seizures (HP:0011146)2.30718522
44Sclerocornea (HP:0000647)2.29909458
45Visual hallucinations (HP:0002367)2.29728219
46Tubular atrophy (HP:0000092)2.27412723
47Supranuclear gaze palsy (HP:0000605)2.25991217
48Increased CSF lactate (HP:0002490)2.24609536
49Increased circulating renin level (HP:0000848)2.22618632
50Aplasia/Hypoplasia of the lens (HP:0008063)2.22013995
51Acute encephalopathy (HP:0006846)2.19063170
52Type II lissencephaly (HP:0007260)2.18768134
53Degeneration of the lateral corticospinal tracts (HP:0002314)2.18629219
54Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.18629219
55Hepatic necrosis (HP:0002605)2.18151560
56Abnormal ciliary motility (HP:0012262)2.17483176
57Hypomagnesemia (HP:0002917)2.17183429
58Abnormal mitochondria in muscle tissue (HP:0008316)2.16458701
59Epileptiform EEG discharges (HP:0011182)2.14416141
60Metaphyseal dysplasia (HP:0100255)2.13216905
61Congenital hepatic fibrosis (HP:0002612)2.10719250
62Hyperventilation (HP:0002883)2.10623564
63Delayed gross motor development (HP:0002194)2.10550616
64EEG with generalized epileptiform discharges (HP:0011198)2.09141976
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.07877653
66Methylmalonic acidemia (HP:0002912)2.06658342
67Ankle clonus (HP:0011448)2.06519933
68Molar tooth sign on MRI (HP:0002419)2.06403680
69Abnormality of midbrain morphology (HP:0002418)2.06403680
70Abnormal respiratory motile cilium physiology (HP:0012261)2.06359779
71Poor coordination (HP:0002370)2.02394150
72Poor speech (HP:0002465)2.01531779
73Left ventricular hypertrophy (HP:0001712)2.01101103
74Nephronophthisis (HP:0000090)2.00542689
75Dynein arm defect of respiratory motile cilia (HP:0012255)1.99135860
76Absent/shortened dynein arms (HP:0200106)1.99135860
77True hermaphroditism (HP:0010459)1.99106451
78Renal cortical cysts (HP:0000803)1.98383168
79Abnormal rod and cone electroretinograms (HP:0008323)1.97755180
80Hypsarrhythmia (HP:0002521)1.96585157
81Abnormality of renal resorption (HP:0011038)1.96337902
82Polydipsia (HP:0001959)1.94504619
83Abnormal drinking behavior (HP:0030082)1.94504619
84Abnormality of dentin (HP:0010299)1.94090177
85Progressive inability to walk (HP:0002505)1.93898745
86Anencephaly (HP:0002323)1.92403322
87Follicular hyperkeratosis (HP:0007502)1.91806198
88Broad foot (HP:0001769)1.91793918
89Scanning speech (HP:0002168)1.91356001
90Cerebellar dysplasia (HP:0007033)1.91213464
91Specific learning disability (HP:0001328)1.90475401
92Male pseudohermaphroditism (HP:0000037)1.88320420
93Pancreatic fibrosis (HP:0100732)1.88146801
94Progressive macrocephaly (HP:0004481)1.86976336
95Menstrual irregularities (HP:0000858)1.85412853
96Hyperglycinemia (HP:0002154)1.84826674
97Cutaneous finger syndactyly (HP:0010554)1.83080021
98Abnormality of glycolysis (HP:0004366)1.82381208
99Increased serum pyruvate (HP:0003542)1.82381208
100Decreased testicular size (HP:0008734)1.82181285
101Abnormality of the dental root (HP:0006486)1.82131328
102Taurodontia (HP:0000679)1.82131328
103Abnormality of permanent molar morphology (HP:0011071)1.82131328
104Abnormality of calcium-phosphate metabolism (HP:0100530)1.81856765
105Agitation (HP:0000713)1.81292254
106Furrowed tongue (HP:0000221)1.80847291
107Truncal ataxia (HP:0002078)1.80846032
108Termporal pattern (HP:0011008)1.80244753
109Insidious onset (HP:0003587)1.80244753
110Prominent nasal bridge (HP:0000426)1.79677928
111Abnormality of the corticospinal tract (HP:0002492)1.78946014
112Narrow forehead (HP:0000341)1.77163441
113Abnormality of magnesium homeostasis (HP:0004921)1.77009280
114Limb dystonia (HP:0002451)1.76556266
115Hypoplasia of the brainstem (HP:0002365)1.76288555
116Aplasia/Hypoplasia of the brainstem (HP:0007362)1.76288555
117Abnormality of the dental pulp (HP:0006479)1.76010625
118Abnormality of the phalanges of the 2nd finger (HP:0009541)1.75770153
119Cutaneous syndactyly (HP:0012725)1.74481905
120Oculomotor apraxia (HP:0000657)1.73781658
121Abnormal respiratory epithelium morphology (HP:0012253)1.73342379
122Abnormal respiratory motile cilium morphology (HP:0005938)1.73342379
123Bile duct proliferation (HP:0001408)1.73151955
124Abnormal biliary tract physiology (HP:0012439)1.73151955
125Cerebral inclusion bodies (HP:0100314)1.72746127
126Postaxial hand polydactyly (HP:0001162)1.72363514
127Lower limb muscle weakness (HP:0007340)1.72295745
1283-Methylglutaconic aciduria (HP:0003535)1.71569145
129Abnormality of molar morphology (HP:0011070)1.71159767
130Abnormality of molar (HP:0011077)1.71159767
131Lissencephaly (HP:0001339)1.70758133
132Anxiety (HP:0000739)1.70595300
133Preaxial hand polydactyly (HP:0001177)1.70559707
134Aplasia/Hypoplasia of the fibula (HP:0006492)1.70128731
135Mitochondrial inheritance (HP:0001427)1.69896239
136Generalized tonic-clonic seizures (HP:0002069)1.68795982
137Broad-based gait (HP:0002136)1.68386740
138Polyphagia (HP:0002591)1.67862329
139Optic disc pallor (HP:0000543)1.67620081
140Thickened helices (HP:0000391)1.67121223
141Narrow nasal bridge (HP:0000446)1.66992461
142Renal Fanconi syndrome (HP:0001994)1.66554387
143Astigmatism (HP:0000483)1.66347305
144Myelomeningocele (HP:0002475)1.66182233
145Increased hepatocellular lipid droplets (HP:0006565)1.65878410
146Fibular hypoplasia (HP:0003038)1.65312917
147Abnormality of macular pigmentation (HP:0008002)1.64937759
148Chronic bronchitis (HP:0004469)1.64696927
149Fibular aplasia (HP:0002990)1.63231182
150Bony spicule pigmentary retinopathy (HP:0007737)1.61483540
151Aganglionic megacolon (HP:0002251)1.60868537
152Cerebral edema (HP:0002181)1.58355421
153Lipid accumulation in hepatocytes (HP:0006561)1.57640012
154Muscular hypotonia of the trunk (HP:0008936)1.57193775
155Short foot (HP:0001773)1.56499463
156Inability to walk (HP:0002540)1.54360896
157Absent rod-and cone-mediated responses on ERG (HP:0007688)1.53636494
158Multicystic kidney dysplasia (HP:0000003)1.53258330
159Supernumerary spleens (HP:0009799)1.52135533
160Dental crowding (HP:0000678)1.50846275
161Attenuation of retinal blood vessels (HP:0007843)1.50729857
162Pachygyria (HP:0001302)1.50611988

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.81450302
2MAP4K23.74397374
3CASK3.17550145
4NTRK33.09859340
5TNIK2.93867705
6WNK42.79480825
7EPHA42.73467509
8MUSK2.44449612
9STK392.29627590
10MAP2K72.21483478
11BCR2.21006006
12SIK32.19038462
13MINK12.14008194
14PRPF4B2.09466607
15MARK12.04750456
16MAPK131.99800721
17OXSR11.93213624
18INSRR1.83006217
19PNCK1.81303015
20NUAK11.79639714
21SGK2231.71694847
22SGK4941.71694847
23BMPR1B1.65461993
24LIMK11.63864408
25MAP3K41.62736817
26PRKD31.62131187
27ARAF1.52267937
28PINK11.51968710
29NTRK11.46806741
30PHKG11.45715636
31PHKG21.45715636
32BCKDK1.44256883
33MAP3K121.44120353
34WNK31.37753005
35CDK191.35914952
36NTRK21.32263915
37PLK21.30708551
38MST41.29388496
39KSR21.28426304
40DYRK21.25598419
41LMTK21.22062870
42ZAK1.21516095
43SRPK11.20863743
44BRAF1.18985991
45MAP3K91.17048163
46EIF2AK31.16916620
47PAK31.16583850
48UHMK11.15901423
49WNK11.15315362
50SGK21.12964135
51CAMKK21.05891750
52CCNB11.04307457
53GRK11.01642287
54PRKCE1.01085262
55MAPKAPK51.00991674
56PBK1.00685197
57KSR11.00163445
58AKT30.99125025
59MAP3K20.98896265
60DYRK30.98165108
61TESK10.98004080
62FLT30.97092327
63CDK50.93886102
64CSNK1G20.93581030
65CAMK2A0.91068582
66MAPK150.90063456
67PAK60.86687343
68PTK2B0.86650139
69CAMK2B0.84419422
70ADRBK10.82755894
71MYLK0.82377941
72STK38L0.81931838
73BMPR20.81009387
74EPHA30.79590809
75STK160.79137421
76DYRK1A0.79025613
77PRKCG0.78767805
78PDK20.77540485
79GRK50.77361634
80CSNK1G30.77178876
81CDK140.76731500
82CAMK2D0.75659608
83ADRBK20.74821916
84NEK10.73526676
85ROCK20.72880686
86NEK60.72260392
87ERBB30.70910278
88VRK10.70822703
89CDK180.70817138
90PLK40.70044549
91OBSCN0.68027668
92FER0.64071277
93MAP3K60.63350714
94CSNK1A1L0.63305545
95CAMK1G0.62056544
96MAP2K40.62032442
97CDK150.59910228
98MET0.57649141
99PIK3CA0.57319455
100ACVR1B0.56592174
101BUB10.56219343
102RET0.55636080
103GRK70.55531386
104SGK30.55384987
105MAPKAPK30.55262749
106MAP3K130.55189310
107LATS10.54493445
108CDK11A0.53958567
109STK30.53461617
110PIK3CG0.51675455
111MKNK10.50304185
112CAMK2G0.48590973
113MAP2K10.47813255
114ROCK10.47311245
115MKNK20.47064372
116DDR20.46635799
117TAOK30.45992376
118FRK0.45698523
119MARK20.45589251
120STK240.44875306
121NEK90.44713483
122TGFBR10.43616079
123PLK10.43291840
124CDC42BPA0.43040087
125YES10.42763936
126PRKCH0.42641609
127PRKG10.42258158
128SGK10.41884486
129FGFR10.41220118
130ERBB40.40061920
131FGFR20.38558773
132TSSK60.38398547
133BRSK20.37980241
134CSNK1G10.37850026
135PRKACA0.37760768
136CSNK1A10.37634344
137PRKCQ0.37350973
138WEE10.36340738
139DAPK20.36193139
140PLK30.36085640
141EPHB20.33802039

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.67742060
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.63511701
3Protein export_Homo sapiens_hsa030602.49467886
4Nicotine addiction_Homo sapiens_hsa050332.46198233
5Butanoate metabolism_Homo sapiens_hsa006502.31148672
6Circadian entrainment_Homo sapiens_hsa047132.12163193
7Oxidative phosphorylation_Homo sapiens_hsa001902.11064968
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.08343379
9Collecting duct acid secretion_Homo sapiens_hsa049662.08224001
10Proteasome_Homo sapiens_hsa030502.06874002
11Vibrio cholerae infection_Homo sapiens_hsa051102.06253498
12Insulin secretion_Homo sapiens_hsa049112.03773153
13GABAergic synapse_Homo sapiens_hsa047272.01811849
14Propanoate metabolism_Homo sapiens_hsa006401.94926867
15Serotonergic synapse_Homo sapiens_hsa047261.94612291
16Glutamatergic synapse_Homo sapiens_hsa047241.92063505
17Morphine addiction_Homo sapiens_hsa050321.90166386
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85358398
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85058804
20Dopaminergic synapse_Homo sapiens_hsa047281.82556292
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.81335086
22Taste transduction_Homo sapiens_hsa047421.78515059
23Phototransduction_Homo sapiens_hsa047441.77861477
24Amphetamine addiction_Homo sapiens_hsa050311.73748044
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69880657
26Basal transcription factors_Homo sapiens_hsa030221.69186996
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68827029
28Olfactory transduction_Homo sapiens_hsa047401.64826132
29Parkinsons disease_Homo sapiens_hsa050121.64744488
30Cocaine addiction_Homo sapiens_hsa050301.61795415
31Peroxisome_Homo sapiens_hsa041461.57821119
32Long-term potentiation_Homo sapiens_hsa047201.55062958
33Alzheimers disease_Homo sapiens_hsa050101.53186366
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52287244
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.51642467
36Steroid biosynthesis_Homo sapiens_hsa001001.50623245
37Cholinergic synapse_Homo sapiens_hsa047251.45343984
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35504132
39Fanconi anemia pathway_Homo sapiens_hsa034601.32336711
40Folate biosynthesis_Homo sapiens_hsa007901.30990057
41Fatty acid elongation_Homo sapiens_hsa000621.29130706
42Cardiac muscle contraction_Homo sapiens_hsa042601.26625803
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25865541
44Axon guidance_Homo sapiens_hsa043601.23688220
45RNA polymerase_Homo sapiens_hsa030201.22040586
46Huntingtons disease_Homo sapiens_hsa050161.18806050
47Long-term depression_Homo sapiens_hsa047301.18591859
48Ether lipid metabolism_Homo sapiens_hsa005651.17808821
49RNA degradation_Homo sapiens_hsa030181.14569671
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13603225
51Sphingolipid metabolism_Homo sapiens_hsa006001.12415720
52Gastric acid secretion_Homo sapiens_hsa049711.11318704
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08935549
54Salivary secretion_Homo sapiens_hsa049701.07924306
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07543025
56Circadian rhythm_Homo sapiens_hsa047101.04063452
57Non-homologous end-joining_Homo sapiens_hsa034501.00250644
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.99824271
59Gap junction_Homo sapiens_hsa045400.98464782
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97873576
61Renin secretion_Homo sapiens_hsa049240.97725369
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95342923
63Calcium signaling pathway_Homo sapiens_hsa040200.94503135
64cAMP signaling pathway_Homo sapiens_hsa040240.93787140
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93578376
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87180469
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87153296
68Oxytocin signaling pathway_Homo sapiens_hsa049210.84430418
69N-Glycan biosynthesis_Homo sapiens_hsa005100.81102693
70Sulfur metabolism_Homo sapiens_hsa009200.80429635
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80234175
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.78722409
73Vitamin B6 metabolism_Homo sapiens_hsa007500.78522804
74Melanogenesis_Homo sapiens_hsa049160.78119692
75Pancreatic secretion_Homo sapiens_hsa049720.77635763
76Nucleotide excision repair_Homo sapiens_hsa034200.76724235
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.76693612
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76418167
79Rheumatoid arthritis_Homo sapiens_hsa053230.76019798
80Homologous recombination_Homo sapiens_hsa034400.74834418
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74748973
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74698160
83Fatty acid metabolism_Homo sapiens_hsa012120.74166639
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73343882
85GnRH signaling pathway_Homo sapiens_hsa049120.73133827
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73084172
87Nitrogen metabolism_Homo sapiens_hsa009100.72702368
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72538135
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71567614
90Metabolic pathways_Homo sapiens_hsa011000.70788142
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70747417
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70338308
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69857320
94Oocyte meiosis_Homo sapiens_hsa041140.69819309
95Ras signaling pathway_Homo sapiens_hsa040140.69479287
96Hippo signaling pathway_Homo sapiens_hsa043900.67575403
97Alcoholism_Homo sapiens_hsa050340.66602097
98ErbB signaling pathway_Homo sapiens_hsa040120.66392939
99Phagosome_Homo sapiens_hsa041450.65006521
100Hedgehog signaling pathway_Homo sapiens_hsa043400.64583964
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.64448331
102Glutathione metabolism_Homo sapiens_hsa004800.62832117
103Basal cell carcinoma_Homo sapiens_hsa052170.62268166
104Tryptophan metabolism_Homo sapiens_hsa003800.62262856
105TGF-beta signaling pathway_Homo sapiens_hsa043500.60159076
106Purine metabolism_Homo sapiens_hsa002300.59087899
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58265941
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57831673
109Dilated cardiomyopathy_Homo sapiens_hsa054140.57429792
110Dorso-ventral axis formation_Homo sapiens_hsa043200.57364360
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55735225
112Type II diabetes mellitus_Homo sapiens_hsa049300.55398924
113Selenocompound metabolism_Homo sapiens_hsa004500.55359738
114Thyroid hormone synthesis_Homo sapiens_hsa049180.54145940
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54049037
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53924024
117Chemical carcinogenesis_Homo sapiens_hsa052040.53168695
118Estrogen signaling pathway_Homo sapiens_hsa049150.52324110
119Ovarian steroidogenesis_Homo sapiens_hsa049130.52163213
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50911223
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50050924
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50025071
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49875547
124Wnt signaling pathway_Homo sapiens_hsa043100.48495200
125MAPK signaling pathway_Homo sapiens_hsa040100.48002487
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46995340
127p53 signaling pathway_Homo sapiens_hsa041150.46976316
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46395557
129Linoleic acid metabolism_Homo sapiens_hsa005910.45922724
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44210674
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43336620
132Type I diabetes mellitus_Homo sapiens_hsa049400.42518279
133ABC transporters_Homo sapiens_hsa020100.40968094
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40537390
135Inositol phosphate metabolism_Homo sapiens_hsa005620.40428909
136Pyruvate metabolism_Homo sapiens_hsa006200.40282862
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39500649
138Fatty acid degradation_Homo sapiens_hsa000710.39357059
139Tight junction_Homo sapiens_hsa045300.39142077
140Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39133666
141beta-Alanine metabolism_Homo sapiens_hsa004100.39110850
142Regulation of autophagy_Homo sapiens_hsa041400.38959730
143Renal cell carcinoma_Homo sapiens_hsa052110.37997940
144Phospholipase D signaling pathway_Homo sapiens_hsa040720.37925043
145Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37758366
146Glioma_Homo sapiens_hsa052140.37317303

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