TBC1D14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.54440793
2central nervous system myelination (GO:0022010)5.54440793
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.38531565
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.38531565
5modulation by symbiont of host immune response (GO:0052553)4.38531565
6positive regulation by symbiont of host defense response (GO:0052509)4.38531565
7modulation by symbiont of host defense response (GO:0052031)4.38531565
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.38531565
9histone H3-K36 demethylation (GO:0070544)4.36007882
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.35361782
11glycerophospholipid catabolic process (GO:0046475)4.16835130
12neuron cell-cell adhesion (GO:0007158)4.16768026
13regulation of female gonad development (GO:2000194)4.16137381
14positive regulation of gamma-delta T cell activation (GO:0046645)4.07735326
15synaptic vesicle maturation (GO:0016188)3.99984404
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.92986411
17negative regulation of cell killing (GO:0031342)3.92986411
18locomotory exploration behavior (GO:0035641)3.92596552
19negative regulation of erythrocyte differentiation (GO:0045647)3.89594289
20negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.82599142
21detection of molecule of bacterial origin (GO:0032490)3.72773142
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.72556630
23establishment of mitochondrion localization (GO:0051654)3.67761488
24layer formation in cerebral cortex (GO:0021819)3.64568367
25axon ensheathment (GO:0008366)3.58413600
26ensheathment of neurons (GO:0007272)3.58413600
27myelination (GO:0042552)3.58236944
28detection of other organism (GO:0098543)3.51887187
29L-amino acid import (GO:0043092)3.49863450
30macrophage activation involved in immune response (GO:0002281)3.47934925
31dendrite morphogenesis (GO:0048813)3.42015727
32apical protein localization (GO:0045176)3.39313530
33regulation of synaptic vesicle exocytosis (GO:2000300)3.38697384
34regulation of leukocyte degranulation (GO:0043300)3.38232936
35cerebral cortex radially oriented cell migration (GO:0021799)3.35069031
36detection of external biotic stimulus (GO:0098581)3.33600321
37nerve growth factor signaling pathway (GO:0038180)3.32882138
38synaptic vesicle exocytosis (GO:0016079)3.32240088
39regulation of myeloid leukocyte mediated immunity (GO:0002886)3.31722241
40membrane tubulation (GO:0097320)3.30830972
41regulation of short-term neuronal synaptic plasticity (GO:0048172)3.29132332
42axonal fasciculation (GO:0007413)3.25359724
43histone H3-K9 demethylation (GO:0033169)3.25322497
44positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.23562540
45histone lysine demethylation (GO:0070076)3.22315625
46barbed-end actin filament capping (GO:0051016)3.20109044
47regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.18412578
48epithelial cell differentiation involved in prostate gland development (GO:0060742)3.17612970
49detection of bacterium (GO:0016045)3.16834610
50pyrimidine nucleobase catabolic process (GO:0006208)3.15406658
51positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.13694183
52neuron recognition (GO:0008038)3.11489004
53regulation of NFAT protein import into nucleus (GO:0051532)3.11463908
54response to muramyl dipeptide (GO:0032495)3.11326282
55dendritic spine morphogenesis (GO:0060997)3.10498190
56regulation of regulated secretory pathway (GO:1903305)3.09300016
57regulation of synaptic vesicle transport (GO:1902803)3.08022149
58piRNA metabolic process (GO:0034587)3.07505753
59regulation of collateral sprouting (GO:0048670)3.04681507
60cell migration in hindbrain (GO:0021535)3.04606167
61histone demethylation (GO:0016577)3.04513196
62synaptic vesicle endocytosis (GO:0048488)3.03068047
63regulation of ARF protein signal transduction (GO:0032012)3.00707173
64central nervous system projection neuron axonogenesis (GO:0021952)2.99601608
65negative regulation of axonogenesis (GO:0050771)2.98405997
66long-chain fatty acid biosynthetic process (GO:0042759)2.98180482
67antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.96959507
68mannose metabolic process (GO:0006013)2.96097083
69regulation of gamma-delta T cell activation (GO:0046643)2.94457122
70protein localization to synapse (GO:0035418)2.91649737
71adult walking behavior (GO:0007628)2.91265872
72oligodendrocyte differentiation (GO:0048709)2.89660053
73detection of biotic stimulus (GO:0009595)2.89641682
74peptidyl-tyrosine autophosphorylation (GO:0038083)2.87898975
75regulation of gamma-delta T cell differentiation (GO:0045586)2.87397922
76regulation of B cell receptor signaling pathway (GO:0050855)2.85710374
77exploration behavior (GO:0035640)2.84650413
78positive regulation of cellular amide metabolic process (GO:0034250)2.83266148
79myelin maintenance (GO:0043217)2.83004638
80asymmetric protein localization (GO:0008105)2.82593547
81nucleobase catabolic process (GO:0046113)2.82593268
82antigen processing and presentation of endogenous antigen (GO:0019883)2.82564789
83regulation of mast cell degranulation (GO:0043304)2.82152052
84cellular extravasation (GO:0045123)2.81636291
85myelination in peripheral nervous system (GO:0022011)2.81486957
86peripheral nervous system axon ensheathment (GO:0032292)2.81486957
87protein localization to endosome (GO:0036010)2.81175431
88cytoskeletal anchoring at plasma membrane (GO:0007016)2.78489834
89multicellular organism reproduction (GO:0032504)2.77505589
90regulation of cellular amide metabolic process (GO:0034248)2.76611123
91clathrin coat assembly (GO:0048268)2.75990271
92peptidyl-threonine modification (GO:0018210)2.75972451
93presynaptic membrane organization (GO:0097090)2.75944211
94negative regulation of neurotransmitter secretion (GO:0046929)2.75096360
95organelle transport along microtubule (GO:0072384)2.74041116
96female gamete generation (GO:0007292)2.73941438
97peptidyl-threonine phosphorylation (GO:0018107)2.73414184
98synaptic transmission, glutamatergic (GO:0035249)2.72984673
99vesicle transport along microtubule (GO:0047496)2.71602987
100cytoplasmic mRNA processing body assembly (GO:0033962)2.71574913
1013-UTR-mediated mRNA stabilization (GO:0070935)2.70928843
102protein demethylation (GO:0006482)2.70881410
103protein dealkylation (GO:0008214)2.70881410
104regulation of meiosis (GO:0040020)2.70735269
105ionotropic glutamate receptor signaling pathway (GO:0035235)2.70688067
106response to peptidoglycan (GO:0032494)2.70642470
107negative regulation of toll-like receptor signaling pathway (GO:0034122)2.70088545
108regulation of ARF GTPase activity (GO:0032312)2.69453370
109negative regulation of myotube differentiation (GO:0010832)2.69324299
110regulation of glutamate receptor signaling pathway (GO:1900449)2.69062154
111neutrophil activation involved in immune response (GO:0002283)2.68908606
112substrate-independent telencephalic tangential migration (GO:0021826)2.68418837
113substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.68418837
114positive thymic T cell selection (GO:0045059)2.67645056
115eye photoreceptor cell differentiation (GO:0001754)2.67465703
116photoreceptor cell differentiation (GO:0046530)2.67465703
117embryonic process involved in female pregnancy (GO:0060136)2.67121533
118response to laminar fluid shear stress (GO:0034616)2.66809478
119negative regulation of neurotransmitter transport (GO:0051589)2.66542574
120antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.65919997
121glutamate secretion (GO:0014047)2.65364831
122positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.64432459
123regulation of neuronal synaptic plasticity (GO:0048168)2.64423049
124B cell receptor signaling pathway (GO:0050853)2.63620091
125mitochondrion transport along microtubule (GO:0047497)2.63543329
126establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.63543329
127response to host immune response (GO:0052572)2.61921854
128response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.61921854
129fatty acid elongation (GO:0030497)2.61915144
130protein kinase C signaling (GO:0070528)2.61770020
131regulation of interferon-beta biosynthetic process (GO:0045357)2.61552696
132presynaptic membrane assembly (GO:0097105)2.61028257
133glycine transport (GO:0015816)2.60890617
134regulation of amyloid precursor protein catabolic process (GO:1902991)2.60157181
135vocalization behavior (GO:0071625)2.59900909
136hypotonic response (GO:0006971)2.58673040
137response to host (GO:0075136)2.58625851
138response to host defenses (GO:0052200)2.58625851
139response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.58625851
140positive regulation of Cdc42 GTPase activity (GO:0043089)2.58599642
141RNA stabilization (GO:0043489)2.57010396
142mRNA stabilization (GO:0048255)2.57010396
143regulation of defense response to virus by virus (GO:0050690)2.56766343
144microtubule severing (GO:0051013)2.56639746
145negative regulation of leukocyte mediated immunity (GO:0002704)2.56076494
146regulation of beta-amyloid formation (GO:1902003)2.55899798
147regulation of dendritic spine morphogenesis (GO:0061001)2.53485432
148histone H4 deacetylation (GO:0070933)2.52894501
149amino acid import (GO:0043090)2.52268083
150signal complex assembly (GO:0007172)2.52133781
151respiratory burst (GO:0045730)2.51175218
152regulation of mast cell activation involved in immune response (GO:0033006)2.49854907
153response to lipoprotein particle (GO:0055094)2.47232372
154neuronal ion channel clustering (GO:0045161)2.46715066
155negative regulation of meiotic cell cycle (GO:0051447)2.46393122
156negative regulation of axon extension (GO:0030517)2.45950981
157regulation of Rap GTPase activity (GO:0032317)2.45286442
158cellular response to nerve growth factor stimulus (GO:1990090)2.43596303
159response to nerve growth factor (GO:1990089)2.43596303
160activated T cell proliferation (GO:0050798)2.42764285
161cortical actin cytoskeleton organization (GO:0030866)2.42585362
162gamma-aminobutyric acid transport (GO:0015812)2.41780556
163synaptic vesicle docking involved in exocytosis (GO:0016081)2.41624704
164negative regulation of lymphocyte mediated immunity (GO:0002707)2.41596694
165negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.40435152
166regulation of synapse structural plasticity (GO:0051823)2.39974882
167reproduction (GO:0000003)2.39872022
168dosage compensation (GO:0007549)2.39171825
169central nervous system neuron axonogenesis (GO:0021955)2.38874470
170positive regulation of regulated secretory pathway (GO:1903307)2.38694463
171positive regulation of Rap GTPase activity (GO:0032854)2.37621405
172thymic T cell selection (GO:0045061)2.37575220
173cell-cell junction maintenance (GO:0045217)2.37453935
174regulation of DNA methylation (GO:0044030)2.37095919
175regulation of axonogenesis (GO:0050770)2.36807171
176macrophage activation (GO:0042116)2.35828242
177regulation of clathrin-mediated endocytosis (GO:2000369)2.35813130
178negative regulation of type 2 immune response (GO:0002829)2.34437746
179leukocyte aggregation (GO:0070486)2.33305493
180regulation of early endosome to late endosome transport (GO:2000641)2.33119478
181production of molecular mediator involved in inflammatory response (GO:0002532)2.32690260
182transmission of nerve impulse (GO:0019226)2.32639823
183regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.32064468
184positive regulation of oligodendrocyte differentiation (GO:0048714)2.31750589
185intracellular estrogen receptor signaling pathway (GO:0030520)2.31183746
186glutamate receptor signaling pathway (GO:0007215)2.31156454
187nuclear pore complex assembly (GO:0051292)2.30781748
188negative regulation of cell size (GO:0045792)2.29934197
189microglial cell activation (GO:0001774)2.29523678
190regulation of necroptotic process (GO:0060544)2.29521502
191stress fiber assembly (GO:0043149)2.26382764
192response to interleukin-15 (GO:0070672)2.25916467
193peptidyl-lysine dimethylation (GO:0018027)2.25636429
194actin filament polymerization (GO:0030041)2.25005039
195regulation of nucleobase-containing compound transport (GO:0032239)2.24403427
196positive regulation of receptor recycling (GO:0001921)2.22811385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.26254579
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.67028933
3* VDR_21846776_ChIP-Seq_THP-1_Human3.06864997
4* MYC_22102868_ChIP-Seq_BL_Human3.00384102
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.86749367
6* TCF7_22412390_ChIP-Seq_EML_Mouse2.65590856
7KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.57151518
8VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.56813675
9KDM2B_26808549_Chip-Seq_DND41_Human2.49581076
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.47774063
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.44110753
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.39271640
13GBX2_23144817_ChIP-Seq_PC3_Human2.38223970
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25273798
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.18290905
16LXR_22292898_ChIP-Seq_THP-1_Human2.15316856
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.14909249
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.13163660
19* VDR_24763502_ChIP-Seq_THP-1_Human2.10154763
20DROSHA_22980978_ChIP-Seq_HELA_Human2.09122680
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.04528207
22ELK3_25401928_ChIP-Seq_HUVEC_Human2.04410110
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.01456602
24AR_21572438_ChIP-Seq_LNCaP_Human2.00915043
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.96773033
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94240873
27TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.91401922
28SPI1_23127762_ChIP-Seq_K562_Human1.90138288
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89025524
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88994721
31REST_21632747_ChIP-Seq_MESCs_Mouse1.87630395
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.87585505
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86213937
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.83034221
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79680104
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79078737
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79078737
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77179741
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76628191
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.76159439
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.75831475
42MAF_26560356_Chip-Seq_TH1_Human1.74977314
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73779231
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72165272
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.71650952
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69673064
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69442933
48UTX_26944678_Chip-Seq_JUKART_Human1.67743752
49* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65053665
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64460568
51RACK7_27058665_Chip-Seq_MCF-7_Human1.63012421
52* GATA1_19941827_ChIP-Seq_MEL_Mouse1.62508907
53* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62299738
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61489697
55CLOCK_20551151_ChIP-Seq_293T_Human1.60334805
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60249314
57IRF8_27001747_Chip-Seq_BMDM_Mouse1.57383054
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56692020
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54602474
60GATA1_26923725_Chip-Seq_HPCs_Mouse1.53400785
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.52000495
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.51538488
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.51087562
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.48551225
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48272014
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47239101
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46718453
68* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44444745
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42746989
70JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41688512
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41358409
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39449181
73MAF_26560356_Chip-Seq_TH2_Human1.39235658
74* SCL_19346495_ChIP-Seq_HPC-7_Human1.38273271
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38031272
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37582703
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36709661
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36534449
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35664159
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.34490087
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33863836
82SMC4_20622854_ChIP-Seq_HELA_Human1.31701174
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31201675
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30825968
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30344909
86SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.30234332
87ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29630797
88* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29417066
89RUNX_20019798_ChIP-Seq_JUKART_Human1.28357701
90* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27845359
91SPI1_23547873_ChIP-Seq_NB4_Human1.26385648
92KDM2B_26808549_Chip-Seq_K562_Human1.26217209
93STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.25904653
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25759741
95AHR_22903824_ChIP-Seq_MCF-7_Human1.25117057
96STAT3_23295773_ChIP-Seq_U87_Human1.24546739
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24171882
98CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21857060
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21745305
100IGF1R_20145208_ChIP-Seq_DFB_Human1.21680325
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.21583551
102* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20658104
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20253037
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20253037
105RNF2_27304074_Chip-Seq_NSC_Mouse1.19576176
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19192705
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.18491102
108* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18030839
109* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17534563
110ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17067083
111* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15995924
112NCOR1_26117541_ChIP-Seq_K562_Human1.15328790
113MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15038563
114NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14767099
115CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14766043
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13959945
117MYB_26560356_Chip-Seq_TH1_Human1.13294737
118GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13115752
119* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12137199
120SMAD3_21741376_ChIP-Seq_EPCs_Human1.11992232
121* SMAD4_21799915_ChIP-Seq_A2780_Human1.11854839
122CREB1_26743006_Chip-Seq_LNCaP_Human1.11084242
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10371254
124* RUNX1_27514584_Chip-Seq_MCF-7_Human1.10113954
125ESR2_21235772_ChIP-Seq_MCF-7_Human1.09714478
126SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09375824
127RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09244659
128* TBX20_22328084_ChIP-Seq_HEART_Mouse1.08946402
129* TBX20_22080862_ChIP-Seq_HEART_Mouse1.08946402
130SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08799796
131EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08796748
132SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08172081
133ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07242257
134CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06770965
135CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06309656
136AR_19668381_ChIP-Seq_PC3_Human1.05777002
137ELK4_26923725_Chip-Seq_MESODERM_Mouse1.05150390
138TCF4_23295773_ChIP-Seq_U87_Human1.04263103
139SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04251824
140NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04060547
141UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03912481
142SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03391157
143IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03095156
144PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02309861
145TAF15_26573619_Chip-Seq_HEK293_Human1.02266263
146IRF8_22096565_ChIP-ChIP_GC-B_Human1.01602401
147ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01577786
148* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01539448
149SALL1_21062744_ChIP-ChIP_HESCs_Human1.01345275
150MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01029465
151KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00975849
152SA1_27219007_Chip-Seq_ERYTHROID_Human1.00907134
153TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00843138
154* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00420716
155FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00229800
156* AR_25329375_ChIP-Seq_VCAP_Human1.00154318
157EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99744503
158P68_20966046_ChIP-Seq_HELA_Human0.99436021
159EED_16625203_ChIP-ChIP_MESCs_Mouse0.99152840
160SMAD3_21741376_ChIP-Seq_ESCs_Human0.98183349
161CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98165904
162RING1B_27294783_Chip-Seq_NPCs_Mouse0.98049634
163TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97867980
164LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96918789
165* SMAD4_21741376_ChIP-Seq_EPCs_Human0.96575867
166KDM2B_26808549_Chip-Seq_JURKAT_Human0.96393458
167* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96371229
168* SMAD4_21741376_ChIP-Seq_HESCs_Human0.95754914
169* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95713185
170CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95396542
171OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95328732
172MYB_26560356_Chip-Seq_TH2_Human0.95292178
173* SMAD3_21741376_ChIP-Seq_HESCs_Human0.95161494
174SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95041808
175TBL1_22424771_ChIP-Seq_293T_Human0.93984884
176DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93236737
177* TET1_21490601_ChIP-Seq_MESCs_Mouse0.91916293
178SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91141257
179RING1B_27294783_Chip-Seq_ESCs_Mouse0.90586202
180KDM2B_26808549_Chip-Seq_REH_Human0.90048041
181P300_19829295_ChIP-Seq_ESCs_Human0.89927885

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.90950157
2MP0003880_abnormal_central_pattern3.72406092
3MP0004270_analgesia3.57461313
4MP0003705_abnormal_hypodermis_morpholog3.24890100
5MP0002877_abnormal_melanocyte_morpholog3.03875704
6MP0000920_abnormal_myelination3.02577930
7MP0003635_abnormal_synaptic_transmissio2.95553303
8MP0000778_abnormal_nervous_system2.91207269
9MP0003300_gastrointestinal_ulcer2.84524565
10MP0002653_abnormal_ependyma_morphology2.80226149
11MP0004885_abnormal_endolymph2.78943419
12MP0004381_abnormal_hair_follicle2.74812346
13MP0003436_decreased_susceptibility_to2.64039586
14MP0005423_abnormal_somatic_nervous2.59171035
15MP0002063_abnormal_learning/memory/cond2.58234220
16MP0003329_amyloid_beta_deposits2.57632863
17MP0003303_peritoneal_inflammation2.51783085
18MP0003191_abnormal_cellular_cholesterol2.46675198
19MP0003787_abnormal_imprinting2.38911164
20MP0002009_preneoplasia2.32280885
21MP0002064_seizures2.31741459
22MP0003690_abnormal_glial_cell2.20243815
23MP0003724_increased_susceptibility_to2.16190686
24MP0001486_abnormal_startle_reflex2.12883448
25MP0002572_abnormal_emotion/affect_behav2.09878593
26MP0009745_abnormal_behavioral_response2.07311975
27MP0000569_abnormal_digit_pigmentation2.03264242
28MP0002734_abnormal_mechanical_nocicepti2.02578146
29MP0005451_abnormal_body_composition2.02154187
30MP0005076_abnormal_cell_differentiation2.02009014
31MP0003828_pulmonary_edema1.97461895
32MP0001529_abnormal_vocalization1.94959211
33MP0002419_abnormal_innate_immunity1.94948381
34MP0004947_skin_inflammation1.92153495
35MP0000955_abnormal_spinal_cord1.87697736
36MP0002272_abnormal_nervous_system1.86493635
37MP0009278_abnormal_bone_marrow1.84623702
38MP0003634_abnormal_glial_cell1.83474502
39MP0001905_abnormal_dopamine_level1.79862424
40MP0003453_abnormal_keratinocyte_physiol1.75843903
41MP0003763_abnormal_thymus_physiology1.74858357
42MP0003183_abnormal_peptide_metabolism1.65370441
43MP0004742_abnormal_vestibular_system1.64623138
44MP0002882_abnormal_neuron_morphology1.64339229
45MP0002796_impaired_skin_barrier1.63583800
46MP0003091_abnormal_cell_migration1.62162725
47MP0003632_abnormal_nervous_system1.60857982
48MP0004811_abnormal_neuron_physiology1.60435565
49MP0001968_abnormal_touch/_nociception1.60320387
50MP0001970_abnormal_pain_threshold1.59204533
51MP0003566_abnormal_cell_adhesion1.56440659
52MP0004264_abnormal_extraembryonic_tissu1.55737457
53MP0009046_muscle_twitch1.55305624
54MP0000604_amyloidosis1.54288053
55MP0008569_lethality_at_weaning1.50767235
56MP0002735_abnormal_chemical_nociception1.45870914
57MP0002184_abnormal_innervation1.42671752
58MP0003718_maternal_effect1.42602062
59MP0002152_abnormal_brain_morphology1.42464380
60MP0005025_abnormal_response_to1.42291824
61MP0008877_abnormal_DNA_methylation1.41522766
62MP0005410_abnormal_fertilization1.41324005
63MP0002736_abnormal_nociception_after1.40340328
64MP0002396_abnormal_hematopoietic_system1.39783515
65MP0001485_abnormal_pinna_reflex1.39661845
66MP0003172_abnormal_lysosome_physiology1.37080307
67MP0002733_abnormal_thermal_nociception1.36505924
68MP0003631_nervous_system_phenotype1.35451055
69MP0009840_abnormal_foam_cell1.35300671
70MP0004185_abnormal_adipocyte_glucose1.34645269
71MP0005464_abnormal_platelet_physiology1.34486812
72MP0005248_abnormal_Harderian_gland1.33961925
73MP0002420_abnormal_adaptive_immunity1.33512326
74MP0002998_abnormal_bone_remodeling1.33278207
75MP0000858_altered_metastatic_potential1.33208445
76MP0002229_neurodegeneration1.32353826
77MP0001819_abnormal_immune_cell1.31957996
78MP0001800_abnormal_humoral_immune1.29148028
79MP0002066_abnormal_motor_capabilities/c1.28851237
80MP0003221_abnormal_cardiomyocyte_apopto1.28333338
81MP0005409_darkened_coat_color1.27866130
82MP0002557_abnormal_social/conspecific_i1.27393910
83MP0004924_abnormal_behavior1.27360560
84MP0005386_behavior/neurological_phenoty1.27360560
85MP0000685_abnormal_immune_system1.25447966
86MP0001440_abnormal_grooming_behavior1.25420837
87MP0004233_abnormal_muscle_weight1.24867369
88MP0010352_gastrointestinal_tract_polyps1.24680949
89MP0001835_abnormal_antigen_presentation1.22563317
90MP0003633_abnormal_nervous_system1.20995668
91MP0002067_abnormal_sensory_capabilities1.19991220
92MP0004510_myositis1.17702564
93MP0004858_abnormal_nervous_system1.17237069
94MP0002452_abnormal_antigen_presenting1.16742896
95MP0000703_abnormal_thymus_morphology1.16715528
96MP0003861_abnormal_nervous_system1.16342346
97MP0008260_abnormal_autophagy1.15977388
98MP0000631_abnormal_neuroendocrine_gland1.15652748
99MP0002166_altered_tumor_susceptibility1.14897166
100MP0002723_abnormal_immune_serum1.12420291
101MP0002398_abnormal_bone_marrow1.11903081
102MP0003866_abnormal_defecation1.10951561
103MP0005310_abnormal_salivary_gland1.10801420
104MP0010678_abnormal_skin_adnexa1.09269249
105MP0005000_abnormal_immune_tolerance1.07504222
106MP0001502_abnormal_circadian_rhythm1.07216095
107MP0002752_abnormal_somatic_nervous1.05785702
108MP0005666_abnormal_adipose_tissue1.05315525
109MP0004142_abnormal_muscle_tone1.05003686
110MP0000462_abnormal_digestive_system1.04423688
111MP0001929_abnormal_gametogenesis1.03844087
112MP0001963_abnormal_hearing_physiology1.03726458
113MP0005551_abnormal_eye_electrophysiolog1.03114295
114MP0001849_ear_inflammation1.03031195
115MP0000716_abnormal_immune_system1.01326979
116MP0006072_abnormal_retinal_apoptosis0.98570120
117MP0002722_abnormal_immune_system0.98097302
118MP0001790_abnormal_immune_system0.97176954
119MP0005387_immune_system_phenotype0.97176954
120MP0001533_abnormal_skeleton_physiology0.96427181
121MP0008961_abnormal_basal_metabolism0.96240701
122MP0005621_abnormal_cell_physiology0.95938683
123MP0004130_abnormal_muscle_cell0.95178501
124MP0000377_abnormal_hair_follicle0.94575092
125MP0000537_abnormal_urethra_morphology0.94294966
126MP0001915_intracranial_hemorrhage0.94161157
127MP0000465_gastrointestinal_hemorrhage0.94060872
128MP0004883_abnormal_blood_vessel0.93209487
129MP0005645_abnormal_hypothalamus_physiol0.91311236
130MP0008004_abnormal_stomach_pH0.91087011
131MP0002161_abnormal_fertility/fecundity0.90964706
132MP0000747_muscle_weakness0.90827659
133MP0004808_abnormal_hematopoietic_stem0.90739819
134MP0010155_abnormal_intestine_physiology0.88352412
135MP0010234_abnormal_vibrissa_follicle0.87992291
136MP0000579_abnormal_nail_morphology0.87987603
137MP0005646_abnormal_pituitary_gland0.87734082
138MP0003698_abnormal_male_reproductive0.87324465
139MP0005501_abnormal_skin_physiology0.85511859
140MP0003075_altered_response_to0.84680364
141MP0003699_abnormal_female_reproductive0.84034043
142MP0000733_abnormal_muscle_development0.81615631
143MP0005195_abnormal_posterior_eye0.81183002
144MP0003950_abnormal_plasma_membrane0.80492795
145MP0001730_embryonic_growth_arrest0.79940947
146MP0000490_abnormal_crypts_of0.79828507
147MP0002429_abnormal_blood_cell0.79631345
148MP0002405_respiratory_system_inflammati0.79555632
149MP0001851_eye_inflammation0.79492228
150MP0002102_abnormal_ear_morphology0.79397206
151MP0003656_abnormal_erythrocyte_physiolo0.79352404
152MP0002822_catalepsy0.79132747
153MP0003121_genomic_imprinting0.78939676
154MP0005671_abnormal_response_to0.78446437
155MP0001216_abnormal_epidermal_layer0.76438354
156MP0005394_taste/olfaction_phenotype0.75861875
157MP0005499_abnormal_olfactory_system0.75861875
158MP0005397_hematopoietic_system_phenotyp0.75666665
159MP0001545_abnormal_hematopoietic_system0.75666665
160MP0001346_abnormal_lacrimal_gland0.75479507
161MP0003879_abnormal_hair_cell0.74850116
162MP0000015_abnormal_ear_pigmentation0.73502584
163MP0010630_abnormal_cardiac_muscle0.73317925
164MP0002132_abnormal_respiratory_system0.72923671
165MP0001177_atelectasis0.72151606
166MP0009780_abnormal_chondrocyte_physiolo0.71720029
167MP0005058_abnormal_lysosome_morphology0.71617021
168MP0002295_abnormal_pulmonary_circulatio0.71458232
169MP0000689_abnormal_spleen_morphology0.71318592
170MP0005075_abnormal_melanosome_morpholog0.71119957
171MP0000678_abnormal_parathyroid_gland0.70191435
172MP0004043_abnormal_pH_regulation0.67794243
173MP0002090_abnormal_vision0.65836738
174MP0003448_altered_tumor_morphology0.65344057
175MP0009672_abnormal_birth_weight0.64960408
176MP0000653_abnormal_sex_gland0.64952287
177MP0002069_abnormal_eating/drinking_beha0.64923091
178MP0000026_abnormal_inner_ear0.64083898
179MP0002133_abnormal_respiratory_system0.63759521

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)4.95667864
2Eczematoid dermatitis (HP:0000976)4.57346099
3Supranuclear gaze palsy (HP:0000605)4.56631113
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.50054836
5Degeneration of the lateral corticospinal tracts (HP:0002314)4.50054836
6Abnormality of the corticospinal tract (HP:0002492)4.27677031
7Cerebral inclusion bodies (HP:0100314)3.90016899
8Myokymia (HP:0002411)3.89678215
9Termporal pattern (HP:0011008)3.67311876
10Insidious onset (HP:0003587)3.67311876
11Spastic gait (HP:0002064)3.57358071
12Male infertility (HP:0003251)3.36400487
13Ankle clonus (HP:0011448)3.29113778
14Mutism (HP:0002300)3.12091344
15Recurrent bacterial skin infections (HP:0005406)3.11733701
16Recurrent abscess formation (HP:0002722)3.02099068
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.01740896
18Centrally nucleated skeletal muscle fibers (HP:0003687)2.95848164
19Urinary bladder sphincter dysfunction (HP:0002839)2.85897880
20Peripheral hypomyelination (HP:0007182)2.83641235
21Colitis (HP:0002583)2.82195755
22Onion bulb formation (HP:0003383)2.81609779
23Gingivitis (HP:0000230)2.79855464
24Sensory axonal neuropathy (HP:0003390)2.76563284
25Amyotrophic lateral sclerosis (HP:0007354)2.71945484
26Urinary urgency (HP:0000012)2.70193039
27Abnormality of macrophages (HP:0004311)2.67357102
28Apathy (HP:0000741)2.64535988
29Cellulitis (HP:0100658)2.63548040
30Arterial tortuosity (HP:0005116)2.61268370
31Spontaneous hematomas (HP:0007420)2.61217018
32Dysmetria (HP:0001310)2.59291604
33Gastrointestinal inflammation (HP:0004386)2.52271242
34Overriding aorta (HP:0002623)2.51651609
35Recurrent gram-negative bacterial infections (HP:0005420)2.49973735
36Intention tremor (HP:0002080)2.48469709
37Neuronal loss in central nervous system (HP:0002529)2.46568652
38Increased IgE level (HP:0003212)2.46350517
39Ankyloglossia (HP:0010296)2.44644214
40Inflammation of the large intestine (HP:0002037)2.39890117
41Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.37838605
42Papillary thyroid carcinoma (HP:0002895)2.37477326
43Insomnia (HP:0100785)2.36674653
44Exercise-induced myalgia (HP:0003738)2.33345128
45Postural instability (HP:0002172)2.32377772
46Subacute progressive viral hepatitis (HP:0006572)2.31659205
47Akinesia (HP:0002304)2.26652426
48Increased connective tissue (HP:0009025)2.25012968
49Germ cell neoplasia (HP:0100728)2.22833748
50Epileptic encephalopathy (HP:0200134)2.20483841
51Diminished motivation (HP:0000745)2.20341372
52Difficulty running (HP:0009046)2.20110100
53Lower limb muscle weakness (HP:0007340)2.18449747
54Clonus (HP:0002169)2.18383146
55Broad face (HP:0000283)2.17881189
56Obstructive sleep apnea (HP:0002870)2.17517850
57Megalencephaly (HP:0001355)2.17276048
58Vascular tortuosity (HP:0004948)2.17200965
59Disinhibition (HP:0000734)2.16144547
60Progressive cerebellar ataxia (HP:0002073)2.15539694
61Abnormal auditory evoked potentials (HP:0006958)2.14475262
62Papilledema (HP:0001085)2.14028847
63Mediastinal lymphadenopathy (HP:0100721)2.07426038
64Aqueductal stenosis (HP:0002410)2.05640559
65Thickened helices (HP:0000391)2.04164966
66Widely spaced teeth (HP:0000687)2.04019324
67Gastrointestinal infarctions (HP:0005244)2.03082793
68Slow saccadic eye movements (HP:0000514)2.01731735
69Flat acetabular roof (HP:0003180)2.00851637
70Impaired vibration sensation in the lower limbs (HP:0002166)2.00257051
71Increased circulating renin level (HP:0000848)2.00160828
72Macroorchidism (HP:0000053)1.99421502
73Focal seizures (HP:0007359)1.98344107
74Action tremor (HP:0002345)1.97522866
75Cerebral hypomyelination (HP:0006808)1.96754175
76Abnormality of the lower motor neuron (HP:0002366)1.96465252
77Drooling (HP:0002307)1.96037128
78Excessive salivation (HP:0003781)1.96037128
79Abnormality of the labia minora (HP:0012880)1.95425849
80Abnormal eating behavior (HP:0100738)1.94755612
81Abnormality of the fingertips (HP:0001211)1.94535033
82Dysmetric saccades (HP:0000641)1.93068490
83Cortical dysplasia (HP:0002539)1.92352675
84Alacrima (HP:0000522)1.91481146
85Hypoplasia of the corpus callosum (HP:0002079)1.91409355
86Osteomyelitis (HP:0002754)1.90961999
87Heterotopia (HP:0002282)1.90346304
88Increased variability in muscle fiber diameter (HP:0003557)1.90329611
89Hyperacusis (HP:0010780)1.89979847
90Viral hepatitis (HP:0006562)1.89294861
91Myositis (HP:0100614)1.89161417
92Abnormality of oral frenula (HP:0000190)1.89076060
93Metaphyseal cupping (HP:0003021)1.88704734
94Inappropriate behavior (HP:0000719)1.88555956
95Orchitis (HP:0100796)1.88247290
96Urticaria (HP:0001025)1.88211944
97Chronic obstructive pulmonary disease (HP:0006510)1.86006883
98Obstructive lung disease (HP:0006536)1.86006883
99Recurrent skin infections (HP:0001581)1.84387937
100Amyloidosis (HP:0011034)1.83723291
101Infertility (HP:0000789)1.82787693
102Abnormality of the columella (HP:0009929)1.82199290
103Abnormality of the thoracic spine (HP:0100711)1.81834976
104Absent septum pellucidum (HP:0001331)1.81088759
105Torticollis (HP:0000473)1.81007123
106Truncal ataxia (HP:0002078)1.80961426
107Facial hemangioma (HP:0000329)1.80801289
108Anosmia (HP:0000458)1.80658383
109Recurrent fungal infections (HP:0002841)1.80489754
110Generalized myoclonic seizures (HP:0002123)1.80018085
111Aplasia/Hypoplasia of the brainstem (HP:0007362)1.78794024
112Hypoplasia of the brainstem (HP:0002365)1.78794024
113Abnormality of binocular vision (HP:0011514)1.78448495
114Diplopia (HP:0000651)1.78448495
115Morphological abnormality of the pyramidal tract (HP:0002062)1.78245343
116Loss of speech (HP:0002371)1.78063154
117Spastic tetraparesis (HP:0001285)1.77998150
118Clumsiness (HP:0002312)1.77841548
119Morphological abnormality of the inner ear (HP:0011390)1.76774231
120Thoracic kyphosis (HP:0002942)1.76772741
121Distal lower limb amyotrophy (HP:0008944)1.76408874
122Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.76319762
123Meningitis (HP:0001287)1.76223363
124Absent speech (HP:0001344)1.75758850
125Foot dorsiflexor weakness (HP:0009027)1.75684737
126Elfin facies (HP:0004428)1.75389546
127Focal motor seizures (HP:0011153)1.74451865
128Upper motor neuron abnormality (HP:0002127)1.73499904
129Overlapping toe (HP:0001845)1.73246677
130Long palpebral fissure (HP:0000637)1.73176207
131Abnormality of skeletal muscle fiber size (HP:0012084)1.72958905
132Abnormal large intestine physiology (HP:0012700)1.72662547
133Spastic paraplegia (HP:0001258)1.72544887
134Abnormality of liposaccharide metabolism (HP:0010968)1.72468468
135Abnormality of glycosphingolipid metabolism (HP:0004343)1.72468468
136Abnormality of glycolipid metabolism (HP:0010969)1.72468468
137Resting tremor (HP:0002322)1.72276930
138Abnormality of the salivary glands (HP:0010286)1.72174178
139Asymmetry of the thorax (HP:0001555)1.71942000
140Vertebral arch anomaly (HP:0008438)1.71732455
141Anomalous pulmonary venous return (HP:0010772)1.70911436
142Abnormality of nail color (HP:0100643)1.70880618
143Segmental peripheral demyelination/remyelination (HP:0003481)1.70109089
144Interstitial pulmonary disease (HP:0006530)1.69814357
145Rapidly progressive (HP:0003678)1.69652692
146Atonic seizures (HP:0010819)1.68488381
147Shallow orbits (HP:0000586)1.68139435
148Limb dystonia (HP:0002451)1.67357659
149Bowel incontinence (HP:0002607)1.66403585
150Broad-based gait (HP:0002136)1.66313109
151Paraplegia (HP:0010550)1.65923232
152Intellectual disability, moderate (HP:0002342)1.64437048
153Chest pain (HP:0100749)1.64045298
154Hyporeflexia of lower limbs (HP:0002600)1.63188717
155Decreased lacrimation (HP:0000633)1.62247751
156Abnormality of the distal phalanx of the thumb (HP:0009617)1.61829691
157Scanning speech (HP:0002168)1.61344910
158Pointed chin (HP:0000307)1.61295264
159Stereotypic behavior (HP:0000733)1.60709670
160Cerebral aneurysm (HP:0004944)1.58456634
161Decreased motor nerve conduction velocity (HP:0003431)1.58434447
162Visual hallucinations (HP:0002367)1.58429766
163Abnormality of the foot musculature (HP:0001436)1.56247642
164Disproportionate tall stature (HP:0001519)1.55753498
165Thin bony cortex (HP:0002753)1.54916356
166Subaortic stenosis (HP:0001682)1.54656931
167Abnormality of the left ventricular outflow tract (HP:0011103)1.54656931
168Spinal cord lesions (HP:0100561)1.54250691
169Syringomyelia (HP:0003396)1.54250691
170Retrobulbar optic neuritis (HP:0100654)1.53446619
171Optic neuritis (HP:0100653)1.53446619
172Increased cerebral lipofuscin (HP:0011813)1.52141039
173Hemorrhage of the eye (HP:0011885)1.52025328
174Milia (HP:0001056)1.50795858
175Uterine leiomyosarcoma (HP:0002891)1.50578019
176Leiomyosarcoma (HP:0100243)1.50578019
177Chronic mucocutaneous candidiasis (HP:0002728)1.50190187
178Recurrent cutaneous fungal infections (HP:0011370)1.50190187
179Depression (HP:0000716)1.49536011
180Polygenic inheritance (HP:0010982)1.49477012

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.51552659
2MAP3K93.50772456
3TRIB33.48426875
4BMPR23.19721789
5MOS2.81748735
6KSR22.50789338
7MAP3K102.49400814
8STK392.46736000
9MAP3K132.38176789
10TYRO32.36889193
11RIPK42.35448601
12CDK122.28143490
13ERN12.26103721
14OXSR12.25208123
15EPHB12.23022352
16PAK62.17153922
17TAOK32.10580278
18EPHA42.03861443
19SMG12.02383802
20RIPK11.94340670
21BLK1.93329179
22PRPF4B1.92030712
23PRKD31.89951871
24DYRK21.83694459
25MAP2K31.72125970
26MAPK131.71852038
27NTRK21.65562625
28SGK2231.65101222
29SGK4941.65101222
30PKN21.56969357
31LIMK11.51166345
32CDK191.48423886
33FGFR41.43320158
34CSK1.38051413
35CSNK1A1L1.37529517
36MAP3K11.37078713
37CSNK1G21.36002914
38PKN11.32194818
39WNK11.30844889
40MAP3K61.30545821
41CSNK1G31.30177279
42NTRK31.24522407
43WNK41.24255054
44PNCK1.22020190
45KSR11.21867228
46FGFR21.21311783
47TYK21.21117528
48ZAP701.19668951
49RET1.17637515
50PTK61.17048949
51NTRK11.16739839
52UHMK11.15324494
53CSNK1G11.15129057
54IRAK41.14230406
55MARK21.13566240
56MAP3K41.12828915
57TAOK11.09070026
58CDK51.08040126
59JAK21.07762637
60FES1.05858456
61HCK1.05600013
62FGR1.05586052
63DAPK21.05457467
64MAP2K41.05223839
65SIK11.05012547
66GRK61.04426684
67BRD41.03361996
68CAMK1D1.01297513
69TNK21.01291342
70MINK11.00264786
71CAMK1G0.99553418
72YES10.95358143
73MAP3K30.92943897
74MAPKAPK50.92590003
75PDGFRA0.92303159
76MAP3K70.90704963
77FGFR30.90641584
78BCR0.90360419
79DYRK1B0.88825791
80DMPK0.87176751
81BTK0.86709162
82LATS20.86533306
83MARK30.86323430
84ARAF0.86195370
85SIK20.86103233
86JAK30.82160429
87ROCK20.81966416
88TAOK20.80022622
89MTOR0.79842950
90CDK60.79797583
91CLK10.79448902
92EEF2K0.78336922
93IRAK20.75607274
94STK100.74637699
95CSF1R0.74459424
96TTN0.73305865
97PRKCH0.71674899
98RPS6KA20.71349371
99ICK0.71319401
100EPHA30.71066910
101MAPK120.70144664
102RAF10.69903006
103MAP2K70.69902210
104BMPR1B0.68631061
105JAK10.68129290
106MAP3K140.67248126
107MAP3K20.66185684
108LRRK20.66172076
109SGK30.65286319
110CDK150.65089409
111MAP3K80.63546869
112STK110.62595257
113CDK180.62470353
114CDC42BPA0.62275635
115LATS10.61748854
116SCYL20.59803175
117SGK20.59673826
118CDK90.59612543
119CDK140.58969762
120RPS6KL10.58188345
121RPS6KC10.58188345
122PRKD20.57942449
123CDK11A0.55940484
124MATK0.55670753
125CAMK40.54895861
126BRAF0.54866148
127TTK0.53498342
128PDGFRB0.52138617
129FYN0.52051006
130SYK0.51662770
131CAMKK10.51519971
132SGK10.51052910
133DYRK1A0.50777449
134PRKCQ0.50767954
135PLK20.47845928
136PDK10.47376638
137CDK40.46885864
138CAMK2A0.45101074
139PAK30.45005671
140CSNK1D0.44964466
141PHKG10.44512507
142PHKG20.44512507
143MAP3K50.44223781
144MAP2K20.43232508
145RPS6KB10.42974614
146PDPK10.42290968
147ALK0.42018354
148ITK0.40290773
149MAP4K10.38648292
150MELK0.38032667
151HIPK20.36991576
152CAMK2B0.36894245
153NEK60.36323197
154TESK20.35223104
155PRKD10.34681904
156PTK2B0.33654120
157STK380.32905369

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.53698979
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.07786862
3Acute myeloid leukemia_Homo sapiens_hsa052212.00496165
4Glutamatergic synapse_Homo sapiens_hsa047241.97739238
5Axon guidance_Homo sapiens_hsa043601.95681595
6Ether lipid metabolism_Homo sapiens_hsa005651.87477577
7Synaptic vesicle cycle_Homo sapiens_hsa047211.80586015
8Long-term depression_Homo sapiens_hsa047301.69597738
9Ovarian steroidogenesis_Homo sapiens_hsa049131.69174750
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.65217695
11Dorso-ventral axis formation_Homo sapiens_hsa043201.64289649
12Renal cell carcinoma_Homo sapiens_hsa052111.60197416
13Morphine addiction_Homo sapiens_hsa050321.59010731
14Circadian entrainment_Homo sapiens_hsa047131.58195193
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.56821301
16Cholinergic synapse_Homo sapiens_hsa047251.49857671
17GABAergic synapse_Homo sapiens_hsa047271.47076493
18GnRH signaling pathway_Homo sapiens_hsa049121.45993909
19Long-term potentiation_Homo sapiens_hsa047201.45545422
20Olfactory transduction_Homo sapiens_hsa047401.42706273
21Dopaminergic synapse_Homo sapiens_hsa047281.39460788
22Nicotine addiction_Homo sapiens_hsa050331.39075925
23mTOR signaling pathway_Homo sapiens_hsa041501.37130629
24Leishmaniasis_Homo sapiens_hsa051401.36696643
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36103936
26ErbB signaling pathway_Homo sapiens_hsa040121.33876116
27Serotonergic synapse_Homo sapiens_hsa047261.33862829
28Steroid biosynthesis_Homo sapiens_hsa001001.32933244
29Thyroid cancer_Homo sapiens_hsa052161.30101077
30Other glycan degradation_Homo sapiens_hsa005111.30069267
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26259819
32Phospholipase D signaling pathway_Homo sapiens_hsa040721.25852318
33Pancreatic cancer_Homo sapiens_hsa052121.23609719
34Tuberculosis_Homo sapiens_hsa051521.21386030
35VEGF signaling pathway_Homo sapiens_hsa043701.20917243
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20507519
37Gastric acid secretion_Homo sapiens_hsa049711.20223335
38Choline metabolism in cancer_Homo sapiens_hsa052311.19723729
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19539420
40Endocytosis_Homo sapiens_hsa041441.18766708
41Insulin signaling pathway_Homo sapiens_hsa049101.18508303
42B cell receptor signaling pathway_Homo sapiens_hsa046621.17429689
43Sphingolipid signaling pathway_Homo sapiens_hsa040711.17334150
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15853112
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.15798926
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15400325
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15323359
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13048876
49Salivary secretion_Homo sapiens_hsa049701.12150076
50Cocaine addiction_Homo sapiens_hsa050301.10887188
51Oocyte meiosis_Homo sapiens_hsa041141.09594851
52Hepatitis B_Homo sapiens_hsa051611.08147323
53Staphylococcus aureus infection_Homo sapiens_hsa051501.08002815
54Oxytocin signaling pathway_Homo sapiens_hsa049211.07423208
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.07359261
56Gap junction_Homo sapiens_hsa045401.06358817
57Glioma_Homo sapiens_hsa052141.05831762
58Chemokine signaling pathway_Homo sapiens_hsa040621.05703274
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05683716
60Ras signaling pathway_Homo sapiens_hsa040141.05117399
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04727363
62Apoptosis_Homo sapiens_hsa042101.03968648
63MAPK signaling pathway_Homo sapiens_hsa040101.03605640
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03594539
65Colorectal cancer_Homo sapiens_hsa052101.00103845
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00083178
67Renin secretion_Homo sapiens_hsa049240.99948964
68Prostate cancer_Homo sapiens_hsa052150.99579809
69Amphetamine addiction_Homo sapiens_hsa050310.99355178
70Estrogen signaling pathway_Homo sapiens_hsa049150.98567136
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98281851
72Toxoplasmosis_Homo sapiens_hsa051450.97600435
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96881060
74Phagosome_Homo sapiens_hsa041450.96772064
75Hepatitis C_Homo sapiens_hsa051600.96115147
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96047281
77Endometrial cancer_Homo sapiens_hsa052130.94297941
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92307106
79Insulin secretion_Homo sapiens_hsa049110.91155969
80Type II diabetes mellitus_Homo sapiens_hsa049300.90800367
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90177069
82Collecting duct acid secretion_Homo sapiens_hsa049660.90074768
83Adherens junction_Homo sapiens_hsa045200.89776345
84Platelet activation_Homo sapiens_hsa046110.89287128
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.89177645
86FoxO signaling pathway_Homo sapiens_hsa040680.88511225
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86819386
88AMPK signaling pathway_Homo sapiens_hsa041520.86764777
89cAMP signaling pathway_Homo sapiens_hsa040240.86328133
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85771563
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84824893
92Non-small cell lung cancer_Homo sapiens_hsa052230.84568945
93Lysosome_Homo sapiens_hsa041420.83443539
94T cell receptor signaling pathway_Homo sapiens_hsa046600.83032250
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82557078
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82069328
97Influenza A_Homo sapiens_hsa051640.81130035
98Notch signaling pathway_Homo sapiens_hsa043300.80712473
99Measles_Homo sapiens_hsa051620.77727715
100Viral carcinogenesis_Homo sapiens_hsa052030.77388345
101Rap1 signaling pathway_Homo sapiens_hsa040150.76473969
102HIF-1 signaling pathway_Homo sapiens_hsa040660.75711142
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.73769993
104Chronic myeloid leukemia_Homo sapiens_hsa052200.73387482
105Insulin resistance_Homo sapiens_hsa049310.71159353
106Linoleic acid metabolism_Homo sapiens_hsa005910.71109348
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70997683
108Inositol phosphate metabolism_Homo sapiens_hsa005620.70927199
109Bladder cancer_Homo sapiens_hsa052190.70391249
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70026015
111Salmonella infection_Homo sapiens_hsa051320.68917828
112Melanogenesis_Homo sapiens_hsa049160.68590876
113Proteoglycans in cancer_Homo sapiens_hsa052050.68428462
114Prion diseases_Homo sapiens_hsa050200.66879463
115Prolactin signaling pathway_Homo sapiens_hsa049170.66076301
116Viral myocarditis_Homo sapiens_hsa054160.65559900
117Vibrio cholerae infection_Homo sapiens_hsa051100.65334008
118Shigellosis_Homo sapiens_hsa051310.64878670
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64833740
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64733857
121Amoebiasis_Homo sapiens_hsa051460.64704836
122TNF signaling pathway_Homo sapiens_hsa046680.64107924
123Focal adhesion_Homo sapiens_hsa045100.63724077
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.63711424
125Wnt signaling pathway_Homo sapiens_hsa043100.61995170
126Sphingolipid metabolism_Homo sapiens_hsa006000.61639198
127Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59379535
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.58845497
129Small cell lung cancer_Homo sapiens_hsa052220.58279256
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56783314
131Herpes simplex infection_Homo sapiens_hsa051680.56456110
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.56250214
133Legionellosis_Homo sapiens_hsa051340.56204217
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55784477
135MicroRNAs in cancer_Homo sapiens_hsa052060.55779374
136Osteoclast differentiation_Homo sapiens_hsa043800.54665319
137Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54065441
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53818859
139Tight junction_Homo sapiens_hsa045300.53486774
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53349019
141Hippo signaling pathway_Homo sapiens_hsa043900.52763488
142Taste transduction_Homo sapiens_hsa047420.52192175
143Hedgehog signaling pathway_Homo sapiens_hsa043400.50807985
144Vitamin B6 metabolism_Homo sapiens_hsa007500.49850619
145Circadian rhythm_Homo sapiens_hsa047100.48927004

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