TBC1D13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1diaphragm development (GO:0060539)9.34303869
2arginine catabolic process (GO:0006527)9.05970441
3skeletal muscle organ development (GO:0060538)8.39690883
4pyrimidine-containing compound salvage (GO:0008655)8.24796832
5pyrimidine nucleoside salvage (GO:0043097)8.24796832
6cellular protein complex localization (GO:0034629)8.17277186
7regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)7.98053321
8positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)7.58384848
9negative regulation of calcium ion transport into cytosol (GO:0010523)7.35262821
10negative regulation of vascular permeability (GO:0043116)7.05752806
11negative regulation of neurotransmitter transport (GO:0051589)7.01347278
12arginine metabolic process (GO:0006525)6.99681503
13UMP biosynthetic process (GO:0006222)6.79443542
14pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)6.79443542
15UMP metabolic process (GO:0046049)6.79443542
16pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)6.79443542
17negative regulation of peptidyl-threonine phosphorylation (GO:0010801)6.78297804
183-UTR-mediated mRNA stabilization (GO:0070935)6.57136826
19negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)6.38984262
20response to lipoprotein particle (GO:0055094)6.23343610
21exogenous drug catabolic process (GO:0042738)5.81650942
22positive regulation of guanylate cyclase activity (GO:0031284)5.72563068
23nucleotide salvage (GO:0043173)5.72294783
24pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)5.63908969
25protein complex localization (GO:0031503)5.53608072
26negative regulation of potassium ion transport (GO:0043267)5.45296441
27positive regulation of receptor biosynthetic process (GO:0010870)5.39250963
28pyrimidine nucleoside monophosphate metabolic process (GO:0009129)5.35445911
29nucleoside salvage (GO:0043174)5.30380029
30regulation of cholesterol biosynthetic process (GO:0045540)5.27855192
31regulation of guanylate cyclase activity (GO:0031282)5.25954342
32adenine nucleotide transport (GO:0051503)5.25831658
33activation of MAPKKK activity (GO:0000185)5.21249474
34protein heterotrimerization (GO:0070208)5.14150316
35regulation of nuclear cell cycle DNA replication (GO:0033262)5.00147310
36positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)4.87941317
37regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)4.86877127
38histone H3-K4 methylation (GO:0051568)4.72324491
39positive regulation of DNA-dependent DNA replication (GO:2000105)4.71331193
40negative regulation of granulocyte differentiation (GO:0030853)4.68866517
41regulation of stem cell maintenance (GO:2000036)4.49668925
42hypotonic response (GO:0006971)4.48256080
43regulation of neurotransmitter uptake (GO:0051580)4.48027439
44positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.40756855
45negative regulation of protein kinase B signaling (GO:0051898)4.38256623
46nerve growth factor signaling pathway (GO:0038180)4.32162499
47negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.23723497
48purine nucleotide transport (GO:0015865)4.21850237
49regulation of mitochondrial translation (GO:0070129)4.20625324
50drug catabolic process (GO:0042737)4.20462431
51negative regulation of alcohol biosynthetic process (GO:1902931)4.18386323
52nitric oxide biosynthetic process (GO:0006809)4.13784407
53negative regulation of macrophage differentiation (GO:0045650)4.12102669
54ncRNA 3-end processing (GO:0043628)4.09478270
55chromatin silencing (GO:0006342)4.06586370
56regulation of integrin activation (GO:0033623)4.06326191
57positive regulation of signal transduction by p53 class mediator (GO:1901798)4.00757212
58purine ribonucleotide transport (GO:0015868)3.96461227
59urea cycle (GO:0000050)3.96232504
60histone H4-K12 acetylation (GO:0043983)3.93127907
61ribosomal small subunit assembly (GO:0000028)3.92803900
62CTP metabolic process (GO:0046036)3.86079501
63CTP biosynthetic process (GO:0006241)3.86079501
64pre-miRNA processing (GO:0031054)3.85030538
65regulation of protein deacetylation (GO:0090311)3.82489659
66negative regulation of T cell receptor signaling pathway (GO:0050860)3.80636354
67negative regulation of potassium ion transmembrane transport (GO:1901380)3.78783765
68regulation of hippo signaling (GO:0035330)3.77777715
69heterochromatin organization (GO:0070828)3.77053347
70positive regulation of histone acetylation (GO:0035066)3.76222527
71myoblast fusion (GO:0007520)3.74301953
72lateral sprouting from an epithelium (GO:0060601)3.71762013
73negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.67462191
74pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.66671241
75regulation of posttranscriptional gene silencing (GO:0060147)3.66138891
76regulation of gene silencing by miRNA (GO:0060964)3.66138891
77regulation of gene silencing by RNA (GO:0060966)3.66138891
78regulation of cell size (GO:0008361)3.62653430
79DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.60210682
80urea metabolic process (GO:0019627)3.58462712
81Rap protein signal transduction (GO:0032486)3.57926444
82regulation of oxidative phosphorylation (GO:0002082)3.57391955
83response to nerve growth factor (GO:1990089)3.52794201
84cellular response to nerve growth factor stimulus (GO:1990090)3.52794201
85regulation of mRNA catabolic process (GO:0061013)3.50747896
86dosage compensation (GO:0007549)3.47117290
87nitric oxide mediated signal transduction (GO:0007263)3.42518272
88low-density lipoprotein particle clearance (GO:0034383)3.41985976
89positive regulation of catecholamine secretion (GO:0033605)3.41132860
90syncytium formation by plasma membrane fusion (GO:0000768)3.40357144
91positive regulation of protein acetylation (GO:1901985)3.39150635
92positive regulation of peptidyl-lysine acetylation (GO:2000758)3.39150635
93pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.38977406
94positive regulation of cGMP biosynthetic process (GO:0030828)3.37678803
95neurotransmitter biosynthetic process (GO:0042136)3.37671745
96modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.36496270
97positive regulation by organism of defense response of other organism involved in symbiotic interact3.36496270
98modulation by symbiont of host immune response (GO:0052553)3.36496270
99positive regulation by symbiont of host defense response (GO:0052509)3.36496270
100modulation by symbiont of host defense response (GO:0052031)3.36496270
101modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.36496270
102epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.35683739
103DNA damage response, signal transduction resulting in transcription (GO:0042772)3.32624489
104regulation of cholesterol storage (GO:0010885)3.32589871
105L-alpha-amino acid transmembrane transport (GO:1902475)3.32434642
106negative regulation of interleukin-2 production (GO:0032703)3.32082317
107regulation of translational fidelity (GO:0006450)3.31516946
108apoptotic process involved in morphogenesis (GO:0060561)3.30666412
109regulation of synaptic vesicle transport (GO:1902803)3.30131471
110regulation of monocyte differentiation (GO:0045655)3.28322545
111inactivation of MAPK activity (GO:0000188)3.27263908
112dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.27016793
113regulation of peptidyl-threonine phosphorylation (GO:0010799)3.25690880
114regulation of cholesterol metabolic process (GO:0090181)3.25497775
115positive regulation of sodium ion transmembrane transport (GO:1902307)3.23200807
116embryonic process involved in female pregnancy (GO:0060136)3.23151055
117intracellular estrogen receptor signaling pathway (GO:0030520)3.22042588
118pentose-phosphate shunt (GO:0006098)3.16046133
119histone H4-K8 acetylation (GO:0043982)3.14625506
120histone H4-K5 acetylation (GO:0043981)3.14625506
121embryonic placenta development (GO:0001892)3.14554513
122sulfur amino acid catabolic process (GO:0000098)3.09480028
123epithelial cell differentiation involved in prostate gland development (GO:0060742)3.08241079
124establishment of apical/basal cell polarity (GO:0035089)3.06290159
125positive regulation of SMAD protein import into nucleus (GO:0060391)3.05376794
126regulation of early endosome to late endosome transport (GO:2000641)2.92397052
127NADPH regeneration (GO:0006740)2.88763673
128determination of adult lifespan (GO:0008340)2.87838834
129folic acid-containing compound biosynthetic process (GO:0009396)2.87568788
130apoptotic cell clearance (GO:0043277)2.85641239
131regulation of cholesterol homeostasis (GO:2000188)2.84740018
132maternal placenta development (GO:0001893)2.81467780
133RNA stabilization (GO:0043489)2.80120147
134mRNA stabilization (GO:0048255)2.80120147
135NLS-bearing protein import into nucleus (GO:0006607)2.78266988
136nuclear pore complex assembly (GO:0051292)2.75636055
137regulation of SMAD protein import into nucleus (GO:0060390)2.73253632
138negative regulation of glial cell proliferation (GO:0060253)2.72681410
139positive regulation of interferon-alpha production (GO:0032727)2.70970681
140chromatin assembly (GO:0031497)2.67089248
141trophectodermal cell differentiation (GO:0001829)2.65824839
142proline biosynthetic process (GO:0006561)2.65005942
143lysine metabolic process (GO:0006553)2.64397324
144lysine catabolic process (GO:0006554)2.64397324
145urate metabolic process (GO:0046415)2.64388921
146cellular modified amino acid catabolic process (GO:0042219)2.63628424
147nodal signaling pathway (GO:0038092)2.63284549
148nuclear pore organization (GO:0006999)2.62153402
149protein localization to kinetochore (GO:0034501)2.61994421
150positive regulation of histone deacetylation (GO:0031065)2.61327822
151establishment of monopolar cell polarity (GO:0061162)2.60834963
152establishment or maintenance of monopolar cell polarity (GO:0061339)2.60834963
153vagina development (GO:0060068)2.59843950
154proline metabolic process (GO:0006560)2.58137544
155female genitalia development (GO:0030540)2.54982374
156folic acid metabolic process (GO:0046655)2.54426056
157regulation of interferon-alpha production (GO:0032647)2.51756616
158negative regulation of cell size (GO:0045792)2.48833789
159apoptotic process involved in development (GO:1902742)2.47108172
160spliceosomal tri-snRNP complex assembly (GO:0000244)2.46911661
161valine metabolic process (GO:0006573)2.43030562
162anterior/posterior axis specification, embryo (GO:0008595)2.43016678
163regulation of podosome assembly (GO:0071801)2.42851337
164mitotic G1 DNA damage checkpoint (GO:0031571)2.42654147
165paraxial mesoderm development (GO:0048339)2.42285665
166developmental programmed cell death (GO:0010623)2.40955923
167regulation of interferon-beta biosynthetic process (GO:0045357)2.40411758
168regulation of protein polyubiquitination (GO:1902914)2.40275776
169negative regulation of toll-like receptor signaling pathway (GO:0034122)2.40119228
170histone H4-K16 acetylation (GO:0043984)2.39922946
171regulation of translational termination (GO:0006449)2.38477063
172negative regulation of interleukin-12 production (GO:0032695)2.37320651
173homocysteine metabolic process (GO:0050667)2.37007416
174macrophage activation involved in immune response (GO:0002281)2.36642689
175regulation of RNA export from nucleus (GO:0046831)2.36216377
176serine family amino acid catabolic process (GO:0009071)2.34352898
177negative regulation of viral release from host cell (GO:1902187)2.33959740
178regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.33468123
179response to laminar fluid shear stress (GO:0034616)2.31512974
180regulation of glial cell proliferation (GO:0060251)2.26382614
181glucose catabolic process (GO:0006007)2.25424989
182positive regulation of interferon-beta production (GO:0032728)2.25341452
183intestinal epithelial cell development (GO:0060576)2.25111503
184mitochondrial DNA metabolic process (GO:0032042)2.24441053
185regulation of protein homooligomerization (GO:0032462)2.23777222
186negative regulation of histone methylation (GO:0031061)2.23672439
187tricarboxylic acid metabolic process (GO:0072350)2.23450112
188regulation of NFAT protein import into nucleus (GO:0051532)2.23230607
189response to UV-C (GO:0010225)2.22526059
190regulation of gene silencing (GO:0060968)2.21320215
191B cell mediated immunity (GO:0019724)2.21065436
192positive regulation of protein homooligomerization (GO:0032464)2.20566444
193regulation of sister chromatid cohesion (GO:0007063)2.20553582
194immunoglobulin mediated immune response (GO:0016064)2.19889797
195cellular response to virus (GO:0098586)2.19447153
196positive regulation of cell size (GO:0045793)10.3706993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human5.62214912
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.10681158
3E2F7_22180533_ChIP-Seq_HELA_Human3.63118377
4ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.89521721
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.89492235
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.89492235
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.89492235
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.86999129
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.79695144
10SCL_19346495_ChIP-Seq_HPC-7_Human2.70262921
11MYC_22102868_ChIP-Seq_BL_Human2.66663032
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.62467900
13SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.60469095
14* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.58042940
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.54475838
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.50063391
17* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.36278524
18HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.33178729
19VDR_21846776_ChIP-Seq_THP-1_Human2.30916993
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.26848366
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.25467705
22GATA1_22025678_ChIP-Seq_K562_Human2.12072140
23ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.10724424
24* SMC4_20622854_ChIP-Seq_HELA_Human2.10397765
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.09269223
26STAT3_1855785_ChIP-Seq_MESCs_Mouse2.06723159
27* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.03063372
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.01713307
29RUNX_20019798_ChIP-Seq_JUKART_Human2.01700318
30EZH2_22144423_ChIP-Seq_EOC_Human10.4873493
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.99387106
32* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.95221010
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.94071419
34* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.81995038
35* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.81632916
36* LXR_22292898_ChIP-Seq_THP-1_Human1.81400075
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79692660
38* TCF7_22412390_ChIP-Seq_EML_Mouse1.79675656
39PPARA_22158963_ChIP-Seq_LIVER_Mouse1.78144101
40KDM2B_26808549_Chip-Seq_DND41_Human1.75276189
41* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.74466661
42* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.72242081
43RXR_22158963_ChIP-Seq_LIVER_Mouse1.71770502
44* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.71476757
45ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.69713775
46* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.69026051
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67272853
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.67019897
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.64256287
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62759389
51* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.61841398
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58646154
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.57906021
54DROSHA_22980978_ChIP-Seq_HELA_Human1.57810826
55RACK7_27058665_Chip-Seq_MCF-7_Human1.52088612
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.51888920
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50235200
58* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50041689
59* TET1_21451524_ChIP-Seq_MESCs_Mouse1.49190983
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49186919
61IRF8_21731497_ChIP-ChIP_J774_Mouse1.46380965
62* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.44599881
63* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44013546
64POU5F1_16518401_ChIP-PET_MESCs_Mouse1.38343065
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35951647
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.34815966
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32600230
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32031659
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31072806
70MAF_26560356_Chip-Seq_TH1_Human1.29293351
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27626069
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26946277
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25118461
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24402977
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23241691
76* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.23189968
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.22703845
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22370875
79NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21183908
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20626075
81GATA1_19941826_ChIP-Seq_K562_Human1.20394036
82LXR_22158963_ChIP-Seq_LIVER_Mouse1.20276700
83KDM2B_26808549_Chip-Seq_K562_Human1.19812874
84* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19802276
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18396073
86UTX_26944678_Chip-Seq_JUKART_Human1.17023070
87* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16098739
88OCT4_18692474_ChIP-Seq_MEFs_Mouse1.15099246
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14846415
90* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14752473
91ZNF263_19887448_ChIP-Seq_K562_Human1.13400923
92* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.13037156
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12377857
94ATF3_27146783_Chip-Seq_COLON_Human1.11733341
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11014676
96NCOR1_26117541_ChIP-Seq_K562_Human1.10745881
97* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.10642470
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10604574
99TBX20_22328084_ChIP-Seq_HEART_Mouse1.10564366
100TBX20_22080862_ChIP-Seq_HEART_Mouse1.10564366
101* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09446257
102VDR_24763502_ChIP-Seq_THP-1_Human1.08871714
103BCOR_27268052_Chip-Seq_Bcells_Human1.08577356
104* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.08437387
105TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08349614
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08176102
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07407427
108* NANOG_21062744_ChIP-ChIP_HESCs_Human1.07050810
109MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06757534
110MYC_19079543_ChIP-ChIP_MESCs_Mouse1.06596029
111IRF8_27001747_Chip-Seq_BMDM_Mouse1.06167191
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04717369
113* P68_20966046_ChIP-Seq_HELA_Human1.04710414
114ELK4_26923725_Chip-Seq_MESODERM_Mouse1.04354726
115TFEB_21752829_ChIP-Seq_HELA_Human1.04329356
116KDM2B_26808549_Chip-Seq_JURKAT_Human1.04144301
117* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.04137950
118SMAD4_21741376_ChIP-Seq_ESCs_Human1.04097078
119GATA6_25053715_ChIP-Seq_YYC3_Human1.03848347
120ERG_21242973_ChIP-ChIP_JURKAT_Human1.03548225
121BP1_19119308_ChIP-ChIP_Hs578T_Human1.03511271
122CDX2_20551321_ChIP-Seq_CACO-2_Human1.03477265
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03294860
124SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02858337
125THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02841804
126CLOCK_20551151_ChIP-Seq_293T_Human1.02244444
127GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02126402
128RUNX1_22412390_ChIP-Seq_EML_Mouse1.01988954
129* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.00040077
130RARB_24833708_ChIP-Seq_LIVER_Mouse0.99537184
131* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99419040
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99217315
133RUNX1_27514584_Chip-Seq_MCF-7_Human0.98699780
134ESR2_21235772_ChIP-Seq_MCF-7_Human0.97944094
135CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97439539
136CREB1_26743006_Chip-Seq_LNCaP_Human0.96956830
137SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96923868
138TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95133521
139POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94881412
140CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94364143
141PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94125613
142TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93903636
143* KAP1_27257070_Chip-Seq_ESCs_Mouse0.93870507
144P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93717082
145PHF8_20622854_ChIP-Seq_HELA_Human0.92684917
146SPI1_23127762_ChIP-Seq_K562_Human0.92642876
147SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.92441863
148ETS1_21867929_ChIP-Seq_TH2_Mouse0.90130495
149RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89929075
150PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88631906
151GATA2_19941826_ChIP-Seq_K562_Human0.88490231
152TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.88376357
153GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88069971
154TP53_22127205_ChIP-Seq_IMR90_Human0.87584429
155JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87343498
156DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84874868
157CTCF_21964334_Chip-Seq_Bcells_Human0.84070349
158NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83958201
159CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83911165
160REST_18959480_ChIP-ChIP_MESCs_Mouse0.83818564
161SOX9_24532713_ChIP-Seq_HFSC_Mouse0.82511903
162TP53_23651856_ChIP-Seq_MEFs_Mouse0.82267810
163* MITF_21258399_ChIP-Seq_MELANOMA_Human0.80924444
164* BCL6_27268052_Chip-Seq_Bcells_Human0.79570237
165FOXO3_23340844_ChIP-Seq_DLD1_Human0.78793594

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis7.87728296
2MP0003646_muscle_fatigue7.24033687
3MP0002234_abnormal_pharynx_morphology5.28747960
4MP0004233_abnormal_muscle_weight5.00775343
5MP0010368_abnormal_lymphatic_system4.68087462
6MP0004043_abnormal_pH_regulation3.96768177
7MP0003705_abnormal_hypodermis_morpholog3.74521447
8MP0005645_abnormal_hypothalamus_physiol3.53350881
9MP0005360_urolithiasis3.32106206
10MP0003172_abnormal_lysosome_physiology2.76072411
11MP0010352_gastrointestinal_tract_polyps2.71083481
12MP0004264_abnormal_extraembryonic_tissu2.61952910
13MP0004084_abnormal_cardiac_muscle2.59961806
14MP0005076_abnormal_cell_differentiation2.51755631
15MP0009278_abnormal_bone_marrow2.41305049
16MP0008057_abnormal_DNA_replication2.40967817
17MP0003045_fibrosis2.40277600
18MP0009840_abnormal_foam_cell2.31109982
19MP0001849_ear_inflammation2.31083280
20MP0005058_abnormal_lysosome_morphology2.28166019
21MP0003303_peritoneal_inflammation2.25650813
22MP0003283_abnormal_digestive_organ2.25638127
23MP0008961_abnormal_basal_metabolism2.23422792
24MP0000467_abnormal_esophagus_morphology2.03328162
25MP0004858_abnormal_nervous_system2.01076621
26MP0010307_abnormal_tumor_latency1.97912725
27MP0003566_abnormal_cell_adhesion1.90527260
28MP0003890_abnormal_embryonic-extraembry1.83439480
29MP0006082_CNS_inflammation1.75343525
30MP0002139_abnormal_hepatobiliary_system1.74426989
31MP0000371_diluted_coat_color1.71172575
32MP0004185_abnormal_adipocyte_glucose1.70956614
33MP0002009_preneoplasia1.65660015
34MP0005365_abnormal_bile_salt1.64537344
35MP0000490_abnormal_crypts_of1.64144538
36MP0003436_decreased_susceptibility_to1.63891205
37MP0003718_maternal_effect1.61063138
38MP0003300_gastrointestinal_ulcer1.57782757
39MP0006138_congestive_heart_failure1.53781403
40MP0004036_abnormal_muscle_relaxation1.53293004
41MP0005257_abnormal_intraocular_pressure1.52857449
42MP0002086_abnormal_extraembryonic_tissu1.50933725
43MP0002653_abnormal_ependyma_morphology1.49681657
44MP0000537_abnormal_urethra_morphology1.49662031
45MP0003191_abnormal_cellular_cholesterol1.49653239
46MP0000569_abnormal_digit_pigmentation1.49382616
47MP0001664_abnormal_digestion1.47849056
48MP0000767_abnormal_smooth_muscle1.43949773
49MP0005380_embryogenesis_phenotype1.41661519
50MP0001672_abnormal_embryogenesis/_devel1.41661519
51MP0004019_abnormal_vitamin_homeostasis1.40128151
52MP0002233_abnormal_nose_morphology1.37801026
53MP0000350_abnormal_cell_proliferation1.34483637
54MP0001730_embryonic_growth_arrest1.33324236
55MP0003984_embryonic_growth_retardation1.32812790
56MP0002084_abnormal_developmental_patter1.31962854
57MP0002088_abnormal_embryonic_growth/wei1.31887721
58MP0003448_altered_tumor_morphology1.30778667
59MP0001919_abnormal_reproductive_system1.26861051
60MP0005666_abnormal_adipose_tissue1.26776360
61MP0001501_abnormal_sleep_pattern1.25956679
62MP0010030_abnormal_orbit_morphology1.25496521
63MP0003111_abnormal_nucleus_morphology1.24442467
64MP0001879_abnormal_lymphatic_vessel1.21295750
65MP0005085_abnormal_gallbladder_physiolo1.18624610
66MP0001545_abnormal_hematopoietic_system1.18526735
67MP0005397_hematopoietic_system_phenotyp1.18526735
68MP0004957_abnormal_blastocyst_morpholog1.18326894
69MP0000609_abnormal_liver_physiology1.17503902
70MP0003252_abnormal_bile_duct1.16321175
71MP0004133_heterotaxia1.16274167
72MP0010234_abnormal_vibrissa_follicle1.16174940
73MP0002085_abnormal_embryonic_tissue1.15235620
74MP0003077_abnormal_cell_cycle1.11883041
75MP0008260_abnormal_autophagy1.11222289
76MP0004197_abnormal_fetal_growth/weight/1.10939900
77MP0005083_abnormal_biliary_tract1.10509827
78MP0008775_abnormal_heart_ventricle1.10273382
79MP0008872_abnormal_physiological_respon1.10041877
80MP0005332_abnormal_amino_acid1.08503220
81MP0004484_altered_response_of1.08214757
82MP0002127_abnormal_cardiovascular_syste1.07396328
83MP0000470_abnormal_stomach_morphology1.03782944
84MP0001697_abnormal_embryo_size1.03731276
85MP0003123_paternal_imprinting1.03459122
86MP0001293_anophthalmia1.02474226
87MP0010329_abnormal_lipoprotein_level1.01786587
88MP0005023_abnormal_wound_healing1.01365846
89MP0003119_abnormal_digestive_system1.00831371
90MP0005319_abnormal_enzyme/_coenzyme1.00772199
91MP0005197_abnormal_uvea_morphology0.99976358
92MP0002254_reproductive_system_inflammat0.99299320
93MP0003453_abnormal_keratinocyte_physiol0.97028494
94MP0000685_abnormal_immune_system0.96384188
95MP0005670_abnormal_white_adipose0.95246655
96MP0009643_abnormal_urine_homeostasis0.94084968
97MP0004947_skin_inflammation0.93893251
98MP0002396_abnormal_hematopoietic_system0.92781001
99MP0002116_abnormal_craniofacial_bone0.92502009
100MP0002092_abnormal_eye_morphology0.92216979
101MP0001881_abnormal_mammary_gland0.91971827
102MP0010155_abnormal_intestine_physiology0.91802138
103MP0004883_abnormal_blood_vessel0.91424448
104MP0000598_abnormal_liver_morphology0.91203753
105MP0000477_abnormal_intestine_morphology0.90848183
106MP0002080_prenatal_lethality0.90653660
107MP0003091_abnormal_cell_migration0.90473314
108MP0009115_abnormal_fat_cell0.90257480
109MP0003806_abnormal_nucleotide_metabolis0.88604381
110MP0001348_abnormal_lacrimal_gland0.85718280
111MP0002136_abnormal_kidney_physiology0.85044295
112MP0001764_abnormal_homeostasis0.84425232
113MP0002113_abnormal_skeleton_development0.84340959
114MP0002109_abnormal_limb_morphology0.82738438
115MP0000432_abnormal_head_morphology0.80309451
116MP0005464_abnormal_platelet_physiology0.78874621
117MP0002970_abnormal_white_adipose0.78253234
118MP0009764_decreased_sensitivity_to0.78220518
119MP0009053_abnormal_anal_canal0.77567523
120MP0001440_abnormal_grooming_behavior0.77541432
121MP0001835_abnormal_antigen_presentation0.77469431
122MP0000733_abnormal_muscle_development0.77062112
123MP0001915_intracranial_hemorrhage0.76775243
124MP0005025_abnormal_response_to0.76415417
125MP0000313_abnormal_cell_death0.74509098
126MP0004130_abnormal_muscle_cell0.73378977
127MP0005167_abnormal_blood-brain_barrier0.73060600
128MP0002019_abnormal_tumor_incidence0.73019119
129MP0008770_decreased_survivor_rate0.72219428
130MP0001790_abnormal_immune_system0.71390036
131MP0005387_immune_system_phenotype0.71390036
132MP0000163_abnormal_cartilage_morphology0.71354936
133MP0000858_altered_metastatic_potential0.70810306
134MP0005166_decreased_susceptibility_to0.69316017
135MP0000689_abnormal_spleen_morphology0.68757584
136MP0003075_altered_response_to0.68432115
137MP0010094_abnormal_chromosome_stability0.67281557
138MP0003942_abnormal_urinary_system0.67041160
139MP0005266_abnormal_metabolism0.66807633
140MP0002405_respiratory_system_inflammati0.66770268
141MP0009672_abnormal_birth_weight0.65461600
142MP0003279_aneurysm0.65261468
143MP0000428_abnormal_craniofacial_morphol0.63742789
144MP0003937_abnormal_limbs/digits/tail_de0.62647659
145MP0005499_abnormal_olfactory_system0.62315515
146MP0005394_taste/olfaction_phenotype0.62315515
147MP0003763_abnormal_thymus_physiology0.61791205
148MP0005409_darkened_coat_color0.59436415
149MP0000955_abnormal_spinal_cord0.58060499
150MP0001663_abnormal_digestive_system0.56067268
151MP0008874_decreased_physiological_sensi0.54771978
152MP0000383_abnormal_hair_follicle0.53159110
153MP0004811_abnormal_neuron_physiology0.52837402
154MP0002932_abnormal_joint_morphology0.52338220
155MP0003633_abnormal_nervous_system0.52218210
156MP0002168_other_aberrant_phenotype0.51644337
157MP0003828_pulmonary_edema0.50351082
158MP0001756_abnormal_urination0.47712670
159MP0003631_nervous_system_phenotype0.46952320
160MP0002115_abnormal_skeleton_extremities0.43067383
161MP0001784_abnormal_fluid_regulation0.42190040
162MP0000750_abnormal_muscle_regeneration0.41739197
163MP0010630_abnormal_cardiac_muscle0.37524266
164MP0005381_digestive/alimentary_phenotyp0.37520159
165MP0002128_abnormal_blood_circulation0.37394469
166MP0005390_skeleton_phenotype0.37252504
167MP0001533_abnormal_skeleton_physiology0.36213106
168MP0000534_abnormal_ureter_morphology0.33865645
169MP0001614_abnormal_blood_vessel0.33858255
170MP0002896_abnormal_bone_mineralization0.33359433
171MP0002249_abnormal_larynx_morphology0.32386678
172MP0000631_abnormal_neuroendocrine_gland0.32347935
173MP0001873_stomach_inflammation0.31881009
174MP0008058_abnormal_DNA_repair0.31041682
175MP0005389_reproductive_system_phenotype0.30348927

Predicted human phenotypes

RankGene SetZ-score
1Sparse lateral eyebrow (HP:0005338)8.31417906
2Lip pit (HP:0100267)8.28819298
3Anal stenosis (HP:0002025)7.57741555
4Abnormality of the fingertips (HP:0001211)6.77942593
5Depressed nasal tip (HP:0000437)6.33509418
6Short 5th finger (HP:0009237)5.84232201
7Ureteral stenosis (HP:0000071)5.63114557
8Aplasia/Hypoplasia of the 5th finger (HP:0006262)5.40956266
9Ureteral obstruction (HP:0006000)5.14163664
10Lower limb hyperreflexia (HP:0002395)4.59369129
11Popliteal pterygium (HP:0009756)4.45170116
12Long palpebral fissure (HP:0000637)4.25612776
13Vertebral hypoplasia (HP:0008417)3.97325134
14Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.97325134
15Ectopic kidney (HP:0000086)3.73717423
16Ependymoma (HP:0002888)3.71387837
17Periauricular skin pits (HP:0100277)3.66207956
18Preauricular pit (HP:0004467)3.66207956
19Natal tooth (HP:0000695)3.50699191
20Abnormality of the lower motor neuron (HP:0002366)3.46806099
21Posterior subcapsular cataract (HP:0007787)3.37956255
22Abnormality of the distal phalanges of the toes (HP:0010182)3.20477923
23Hand muscle atrophy (HP:0009130)3.16348951
24Neonatal short-limb short stature (HP:0008921)3.15038834
25Mask-like facies (HP:0000298)3.12562432
26Abnormality of the astrocytes (HP:0100707)3.04838382
27Astrocytoma (HP:0009592)3.04838382
28Abnormality of the periventricular white matter (HP:0002518)2.95849411
29Ectropion (HP:0000656)2.92265477
30Congenital hip dislocation (HP:0001374)2.89301762
31Self-mutilation (HP:0000742)2.85580051
32Autoimmune thrombocytopenia (HP:0001973)2.81182250
33Trismus (HP:0000211)2.73057105
34Facial cleft (HP:0002006)2.72808277
35Neonatal death (HP:0003811)2.72719542
36Spastic diplegia (HP:0001264)2.71914627
37Obstructive sleep apnea (HP:0002870)2.69818701
38Broad thumb (HP:0011304)2.66874030
39Abnormality of glutamine family amino acid metabolism (HP:0010902)2.65108001
40Upper motor neuron abnormality (HP:0002127)2.60629668
41Ulnar bowing (HP:0003031)2.59672997
42Aplasia involving bones of the upper limbs (HP:0009823)2.58368668
43Aplasia of the phalanges of the hand (HP:0009802)2.58368668
44Aplasia involving bones of the extremities (HP:0009825)2.58368668
45Hyperacusis (HP:0010780)2.58199921
46Narrow palate (HP:0000189)2.56096978
47Distal upper limb amyotrophy (HP:0007149)2.55337905
48Upper limb amyotrophy (HP:0009129)2.55337905
49Progressive neurologic deterioration (HP:0002344)2.54419457
50Abnormality of polysaccharide metabolism (HP:0011012)2.53622304
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.53622304
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.53622304
53Cerebral aneurysm (HP:0004944)2.52411883
54Metaphyseal cupping (HP:0003021)2.50008758
55Pheochromocytoma (HP:0002666)2.49870463
56Fatigue (HP:0012378)2.48706841
57Short humerus (HP:0005792)2.43426469
58Rib fusion (HP:0000902)2.42585902
59Broad hallux (HP:0010055)2.42258958
60Pustule (HP:0200039)2.41355134
61Urinary glycosaminoglycan excretion (HP:0003541)2.39975966
62Mucopolysacchariduria (HP:0008155)2.39975966
63Coarctation of aorta (HP:0001680)2.38348704
64Hyperglycinuria (HP:0003108)2.37657367
65Asymmetry of the thorax (HP:0001555)2.34564846
66Cortical dysplasia (HP:0002539)2.34019984
67Pseudobulbar signs (HP:0002200)2.32850731
68Skin pits (HP:0100276)2.31071733
69Turricephaly (HP:0000262)2.30256404
70Annular pancreas (HP:0001734)2.28259919
71Hypochromic microcytic anemia (HP:0004840)2.27514101
72Systemic lupus erythematosus (HP:0002725)2.27139292
73Frequent falls (HP:0002359)2.26997349
74Pterygium (HP:0001059)2.26881255
75Gout (HP:0001997)2.26860122
76Transitional cell carcinoma of the bladder (HP:0006740)2.26164766
77Wide intermamillary distance (HP:0006610)2.24991956
78Recurrent otitis media (HP:0000403)2.23359797
79Multiple enchondromatosis (HP:0005701)2.23146894
80Abnormality of glycolipid metabolism (HP:0010969)2.22374181
81Abnormality of liposaccharide metabolism (HP:0010968)2.22374181
82Abnormality of glycosphingolipid metabolism (HP:0004343)2.22374181
83Abnormality of proline metabolism (HP:0010907)2.21811408
84Hydroxyprolinuria (HP:0003080)2.21811408
85Absent eyebrow (HP:0002223)2.21340408
86Atonic seizures (HP:0010819)2.20767213
87Preaxial foot polydactyly (HP:0001841)2.19246740
88Myocardial infarction (HP:0001658)2.18311000
89Heterotopia (HP:0002282)2.16765960
90Aplasia/hypoplasia of the humerus (HP:0006507)2.12523056
91Absent eyelashes (HP:0000561)2.12345231
92Neuroendocrine neoplasm (HP:0100634)2.08982711
93Esophageal varix (HP:0002040)2.07262243
94Abnormality of cochlea (HP:0000375)2.05364580
95Neoplasm of striated muscle (HP:0009728)2.04882348
96Eczematoid dermatitis (HP:0000976)2.04857999
97Lymphangioma (HP:0100764)2.03017302
98Glioma (HP:0009733)2.01635407
99Macroorchidism (HP:0000053)2.01426221
100Advanced eruption of teeth (HP:0006288)2.01425932
101Renal duplication (HP:0000075)2.01143654
102Broad phalanges of the hand (HP:0009768)2.01139593
103Anal atresia (HP:0002023)2.01034244
104Bladder neoplasm (HP:0009725)2.00557074
105Bladder carcinoma (HP:0002862)2.00557074
106Reduced subcutaneous adipose tissue (HP:0003758)2.00512610
107Abnormality of purine metabolism (HP:0004352)2.00147943
108Intestinal fistula (HP:0100819)1.98542226
109Dysostosis multiplex (HP:0000943)1.98351822
110Subcapsular cataract (HP:0000523)1.97339445
111Abnormal number of incisors (HP:0011064)1.96531765
112Urethral obstruction (HP:0000796)1.96227237
113Large earlobe (HP:0009748)1.96078690
114Delayed puberty (HP:0000823)1.95967842
115Fibular aplasia (HP:0002990)1.94606502
116Broad toe (HP:0001837)1.94056609
117Increased cerebral lipofuscin (HP:0011813)1.93995553
118Precocious puberty (HP:0000826)1.93109233
119Abnormality of serine family amino acid metabolism (HP:0010894)1.92377103
120Abnormality of glycine metabolism (HP:0010895)1.92377103
121Rhabdomyosarcoma (HP:0002859)1.92253130
122Polycythemia (HP:0001901)1.92194359
123Shawl scrotum (HP:0000049)1.92125474
124Elfin facies (HP:0004428)1.91724845
125Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.91439500
126Recurrent gram-negative bacterial infections (HP:0005420)1.90549560
127Spinal muscular atrophy (HP:0007269)1.88008625
128Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.87970862
129Axonal loss (HP:0003447)1.87934914
130Generalized aminoaciduria (HP:0002909)1.87347327
131Broad finger (HP:0001500)1.86852745
132Spastic tetraparesis (HP:0001285)1.85867732
133Mild short stature (HP:0003502)1.85711751
134Abnormality of the motor neurons (HP:0002450)1.85566694
135Abnormal neuron morphology (HP:0012757)1.85566694
136Non-midline cleft lip (HP:0100335)1.84273740
137Tinnitus (HP:0000360)1.82058361
138Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.81922142
139Pathologic fracture (HP:0002756)1.80213198
140Abnormality of sulfur amino acid metabolism (HP:0004339)1.79867221
141Abnormality of nucleobase metabolism (HP:0010932)1.79563630
142Disinhibition (HP:0000734)1.79089015
143Vertebral clefting (HP:0008428)1.79017153
144Absent hand (HP:0004050)1.78358440
145Uterine leiomyosarcoma (HP:0002891)1.78174009
146Leiomyosarcoma (HP:0100243)1.78174009
147Vaginal fistula (HP:0004320)1.76710929
148Resting tremor (HP:0002322)1.76570098
149Hypoplastic scapulae (HP:0000882)1.76002933
150Aplasia/Hypoplasia of the scapulae (HP:0006713)1.76002933
151Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.75441383
152Malignant gastrointestinal tract tumors (HP:0006749)1.74121868
153Gastrointestinal carcinoma (HP:0002672)1.74121868
154Selective tooth agenesis (HP:0001592)1.73936213
155Renal cell carcinoma (HP:0005584)1.73002710
156Blue sclerae (HP:0000592)1.72913816
157Abnormality of the Achilles tendon (HP:0005109)1.72195507
158Cerebral hemorrhage (HP:0001342)1.71750066
159Neoplasm of the oral cavity (HP:0100649)1.71482056
160Broad phalanx (HP:0006009)1.71394879
161Agnosia (HP:0010524)1.70263860
162Dysmetric saccades (HP:0000641)1.70194750
163Abnormal enzyme/coenzyme activity (HP:0012379)1.70059322
164Disproportionate tall stature (HP:0001519)1.69159622
165Thoracic kyphosis (HP:0002942)1.68814078
166Genu recurvatum (HP:0002816)1.68713265
167Visceral angiomatosis (HP:0100761)1.67885297
168Rectal fistula (HP:0100590)1.66987947
169Rectovaginal fistula (HP:0000143)1.66987947
170Abnormality of alkaline phosphatase activity (HP:0004379)1.65176056
171Increased CSF protein (HP:0002922)1.64283308
172Apathy (HP:0000741)1.63790897
173Peripheral demyelination (HP:0011096)1.62053983
174Nephritis (HP:0000123)1.61860059
175Recurrent abscess formation (HP:0002722)1.60400420
176Abnormality of macrophages (HP:0004311)1.58862473
177Bilateral sensorineural hearing impairment (HP:0008619)1.58664378
178Diminished motivation (HP:0000745)1.58660886
179Renovascular hypertension (HP:0100817)1.58521804
180Achilles tendon contracture (HP:0001771)1.57944506
181Vacuolated lymphocytes (HP:0001922)1.57265823
182Gingivitis (HP:0000230)1.55906925
183Cheilitis (HP:0100825)1.55730474

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK248.46423853
2CDK125.48828069
3WNK45.10851454
4STK394.97159696
5CCNB14.81786414
6MAP3K34.10746831
7MAP3K24.06972692
8ERN13.71192900
9PINK13.65157940
10TRIB33.19651148
11ICK2.82761457
12ILK2.56642452
13MAP3K102.51985579
14PKN22.35201422
15TYRO32.33267207
16WNK12.11274373
17MAP3K92.10524730
18EEF2K2.09747616
19MATK2.07605025
20DDR22.03301139
21BMX2.02019112
22PDGFRA2.00015571
23CAMK1D1.78728061
24RIPK11.73508280
25CAMK11.65466739
26NEK11.65430146
27CAMK41.65286045
28FGFR41.58707294
29PAK41.56960824
30RPS6KC11.54047726
31RPS6KL11.54047726
32NEK21.53174886
33ZAK1.48755770
34LATS21.46300278
35LATS11.45352951
36RPS6KA61.42915068
37CSK1.42120136
38GRK61.41963612
39SIK11.32171141
40MTOR1.30888707
41SIK31.27418567
42PTK61.24818731
43NTRK21.24575434
44TRPM71.21835332
45ALK1.21806946
46TAOK21.17672254
47PRKCQ1.17626295
48CDK71.17420015
49SIK21.11557736
50FGR1.08155028
51TYK21.08037778
52EPHA21.06246974
53CSF1R1.04869561
54PRPF4B1.04436285
55CAMK1G0.99822822
56CDK40.98512696
57CDK60.97365767
58KSR10.97003664
59MAP3K60.96724540
60STK100.96618105
61TTK0.95394021
62SCYL20.94895013
63RPS6KA20.92430292
64MAPKAPK50.91260003
65IRAK30.91227496
66BLK0.88976648
67TGFBR20.88162621
68CDC70.87430427
69MAP3K110.83873474
70EPHB20.82765853
71PAK60.82656678
72FGFR30.82540662
73PIM10.81817903
74STK380.79750144
75PDGFRB0.79484276
76STK30.77465867
77MINK10.77399607
78MAP4K10.75098155
79DAPK20.72720453
80UHMK10.71942508
81BRD40.71826266
82CDK90.68925337
83MAPKAPK30.68148414
84TBK10.67250671
85FLT30.67051918
86CHEK20.66015019
87BCKDK0.64922557
88TNK20.64760412
89TTN0.63771380
90JAK20.62986420
91KSR20.62836343
92NEK90.61336526
93PTK20.59995864
94MAPK110.59983254
95DAPK10.59592216
96CAMKK10.59141452
97GSK3A0.58903344
98AKT20.57288274
99CAMKK20.56914665
100DYRK1B0.56395025
101STK38L0.55731689
102SRPK10.55194839
103MAP3K70.55164674
104LRRK20.54910499
105EGFR0.54145429
106MAP3K80.54023605
107HCK0.53895382
108EPHB10.52338771
109TLK10.51981207
110RPS6KB20.50694370
111JAK30.49623851
112KIT0.49147141
113PRKAA10.48982552
114STK40.48713291
115TAOK10.47860312
116ZAP700.47732594
117PAK20.47334678
118JAK10.47204820
119RET0.46259658
120CHUK0.44844209
121CDK20.43942506
122MAPK120.41191042
123ACVR1B0.40977560
124DYRK30.40954309
125WNK30.40849481
126MET0.40267199
127MAP2K20.39422025
128DMPK0.38685826
129TESK20.38279711
130RPS6KA10.37346317
131CHEK10.36352457
132PNCK0.36055868
133PRKG20.35549473
134ATR0.35353709
135MELK0.29467355
136PASK0.26305924
137MAPK130.25318320
138MAP3K50.24373330
139YES10.23679592
140PRKCD0.15880769
141PRKCZ0.14817954
142RPS6KB10.14671701
143IRAK20.14338800
144MAPK90.13636658
145EIF2AK20.13399098
146PDPK10.12046908
147CSNK1G30.11669639
148TNIK0.11481481
149IRAK40.10043246
150SGK20.09496808
151PRKACG0.07598056
152MAPK100.06258252
153RIPK40.06164314
154SGK30.05227419
155CSNK1A1L0.03929013
156SRC0.03816735
157PDK10.03274763
158MAP2K10.02646677
159MAP2K30.01888383
160PRKCA0.01796353
161PRKD30.01363569
162MAPKAPK2-0.0251709
163SGK494-0.0229927
164SGK223-0.0229927
165NTRK1-0.0226520
166SMG1-0.0111957
167ROCK1-0.0089049

Predicted pathways (KEGG)

RankGene SetZ-score
1Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.93979184
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.23681759
3Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.88912993
4N-Glycan biosynthesis_Homo sapiens_hsa005101.88538535
5Lysine degradation_Homo sapiens_hsa003101.88340264
6Glycosaminoglycan degradation_Homo sapiens_hsa005311.87346120
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.83657403
8Arginine biosynthesis_Homo sapiens_hsa002201.82756659
9Nitrogen metabolism_Homo sapiens_hsa009101.78916517
10Arginine and proline metabolism_Homo sapiens_hsa003301.70872813
11Notch signaling pathway_Homo sapiens_hsa043301.67595620
12Sphingolipid signaling pathway_Homo sapiens_hsa040711.67589744
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67075470
14Salivary secretion_Homo sapiens_hsa049701.66837553
15mTOR signaling pathway_Homo sapiens_hsa041501.65293245
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.64954115
17Staphylococcus aureus infection_Homo sapiens_hsa051501.64900547
18Fructose and mannose metabolism_Homo sapiens_hsa000511.56199926
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.55288041
20Fatty acid biosynthesis_Homo sapiens_hsa000611.53040059
21Circadian entrainment_Homo sapiens_hsa047131.53020315
22Dopaminergic synapse_Homo sapiens_hsa047281.47811237
23Renal cell carcinoma_Homo sapiens_hsa052111.44724258
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42128569
25One carbon pool by folate_Homo sapiens_hsa006701.37303594
26Long-term depression_Homo sapiens_hsa047301.33766014
27Biosynthesis of amino acids_Homo sapiens_hsa012301.33128390
28Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.31290483
29Caffeine metabolism_Homo sapiens_hsa002321.31223607
30Endocytosis_Homo sapiens_hsa041441.30264460
31Glioma_Homo sapiens_hsa052141.30048585
32Galactose metabolism_Homo sapiens_hsa000521.29852601
33mRNA surveillance pathway_Homo sapiens_hsa030151.28781604
34Leishmaniasis_Homo sapiens_hsa051401.25841318
35Pyrimidine metabolism_Homo sapiens_hsa002401.24873961
36Chronic myeloid leukemia_Homo sapiens_hsa052201.24319325
37Sulfur relay system_Homo sapiens_hsa041221.23020408
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22139933
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21652471
40Vitamin B6 metabolism_Homo sapiens_hsa007501.21489518
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.20756710
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18591384
43Lysosome_Homo sapiens_hsa041421.18319670
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15261929
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12532244
46Phototransduction_Homo sapiens_hsa047441.11540469
47Carbon metabolism_Homo sapiens_hsa012001.10975074
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10539471
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10356969
50Selenocompound metabolism_Homo sapiens_hsa004501.06021380
51Central carbon metabolism in cancer_Homo sapiens_hsa052301.04664807
52Acute myeloid leukemia_Homo sapiens_hsa052211.04158684
53Pertussis_Homo sapiens_hsa051331.03481857
54Cyanoamino acid metabolism_Homo sapiens_hsa004601.01344515
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00960543
56Tryptophan metabolism_Homo sapiens_hsa003801.00323758
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99290453
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99160807
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99032317
60Adherens junction_Homo sapiens_hsa045200.98864771
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97794519
62TGF-beta signaling pathway_Homo sapiens_hsa043500.97529063
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97288199
64PPAR signaling pathway_Homo sapiens_hsa033200.97141843
65Phagosome_Homo sapiens_hsa041450.94879106
66Pentose phosphate pathway_Homo sapiens_hsa000300.94231283
67Oxytocin signaling pathway_Homo sapiens_hsa049210.93987664
68Fatty acid metabolism_Homo sapiens_hsa012120.92255814
69Bile secretion_Homo sapiens_hsa049760.91856044
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89379282
71Bladder cancer_Homo sapiens_hsa052190.88864104
72MicroRNAs in cancer_Homo sapiens_hsa052060.87594780
73Legionellosis_Homo sapiens_hsa051340.86952123
74Fatty acid degradation_Homo sapiens_hsa000710.86303501
75Insulin resistance_Homo sapiens_hsa049310.86017277
76VEGF signaling pathway_Homo sapiens_hsa043700.85298210
77Other glycan degradation_Homo sapiens_hsa005110.84633741
78Influenza A_Homo sapiens_hsa051640.81869329
79Apoptosis_Homo sapiens_hsa042100.81618608
80Endometrial cancer_Homo sapiens_hsa052130.80709061
81Small cell lung cancer_Homo sapiens_hsa052220.80189621
82Tuberculosis_Homo sapiens_hsa051520.79392404
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79061201
84Herpes simplex infection_Homo sapiens_hsa051680.77701818
85Rap1 signaling pathway_Homo sapiens_hsa040150.77045549
86Long-term potentiation_Homo sapiens_hsa047200.74712788
87Non-small cell lung cancer_Homo sapiens_hsa052230.74029776
88Proteoglycans in cancer_Homo sapiens_hsa052050.73377518
89Focal adhesion_Homo sapiens_hsa045100.72942914
90Osteoclast differentiation_Homo sapiens_hsa043800.71990473
91Fat digestion and absorption_Homo sapiens_hsa049750.71900590
92Renin-angiotensin system_Homo sapiens_hsa046140.71866116
93Butanoate metabolism_Homo sapiens_hsa006500.70965448
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70865375
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68985927
96Hippo signaling pathway_Homo sapiens_hsa043900.67737553
97Shigellosis_Homo sapiens_hsa051310.67726619
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.67501501
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.66916675
100Fatty acid elongation_Homo sapiens_hsa000620.66695614
101Pancreatic cancer_Homo sapiens_hsa052120.66316570
102Folate biosynthesis_Homo sapiens_hsa007900.66230240
103Complement and coagulation cascades_Homo sapiens_hsa046100.66217646
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65716880
105Hepatitis B_Homo sapiens_hsa051610.65661902
106AMPK signaling pathway_Homo sapiens_hsa041520.65483102
107B cell receptor signaling pathway_Homo sapiens_hsa046620.65385800
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.65154870
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64825070
110Starch and sucrose metabolism_Homo sapiens_hsa005000.64692009
111Colorectal cancer_Homo sapiens_hsa052100.64646052
112Viral myocarditis_Homo sapiens_hsa054160.64570392
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63996572
114Prolactin signaling pathway_Homo sapiens_hsa049170.62291938
115Toxoplasmosis_Homo sapiens_hsa051450.62233057
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61833298
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.61779696
118Calcium signaling pathway_Homo sapiens_hsa040200.61703284
119Glycerolipid metabolism_Homo sapiens_hsa005610.61208811
120Viral carcinogenesis_Homo sapiens_hsa052030.60725658
121Renin secretion_Homo sapiens_hsa049240.60450255
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.59023172
123Amphetamine addiction_Homo sapiens_hsa050310.58980189
124Measles_Homo sapiens_hsa051620.58833086
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58655797
126Synaptic vesicle cycle_Homo sapiens_hsa047210.58641035
127HIF-1 signaling pathway_Homo sapiens_hsa040660.58135988
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57911492
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.57853424
130Insulin signaling pathway_Homo sapiens_hsa049100.56958795
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56006658
132ECM-receptor interaction_Homo sapiens_hsa045120.55351786
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53065974
134Non-homologous end-joining_Homo sapiens_hsa034500.52776199
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52480656
136TNF signaling pathway_Homo sapiens_hsa046680.52421698
137Prion diseases_Homo sapiens_hsa050200.52143483
138Amoebiasis_Homo sapiens_hsa051460.52099751
139Vitamin digestion and absorption_Homo sapiens_hsa049770.51777052
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51405297
141Dilated cardiomyopathy_Homo sapiens_hsa054140.50811182
142Gastric acid secretion_Homo sapiens_hsa049710.48775913
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.48319812
144GnRH signaling pathway_Homo sapiens_hsa049120.46105126
145Estrogen signaling pathway_Homo sapiens_hsa049150.43921609
146Choline metabolism in cancer_Homo sapiens_hsa052310.42753924
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42378574
148Melanogenesis_Homo sapiens_hsa049160.41801471
149Inositol phosphate metabolism_Homo sapiens_hsa005620.41163625
150SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39869401
151MAPK signaling pathway_Homo sapiens_hsa040100.36257918
152Glucagon signaling pathway_Homo sapiens_hsa049220.34972671
153ErbB signaling pathway_Homo sapiens_hsa040120.33632650
154Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33304309
155Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31846523
156Olfactory transduction_Homo sapiens_hsa047400.31351510
157Platelet activation_Homo sapiens_hsa046110.31265237
158Chemokine signaling pathway_Homo sapiens_hsa040620.29186279
159Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27966920
160Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27385971
161Hepatitis C_Homo sapiens_hsa051600.25475067
162Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23960644
163cAMP signaling pathway_Homo sapiens_hsa040240.23570885

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