TATDN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)4.92612840
2ATP synthesis coupled proton transport (GO:0015986)4.92612840
3behavioral response to nicotine (GO:0035095)4.69351914
4long-chain fatty acid biosynthetic process (GO:0042759)4.60114539
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.39937976
6mitochondrial respiratory chain complex assembly (GO:0033108)4.33066807
7neuronal action potential propagation (GO:0019227)4.29856650
8DNA deamination (GO:0045006)4.24298336
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.10829555
10electron transport chain (GO:0022900)3.98537626
11establishment of protein localization to mitochondrial membrane (GO:0090151)3.96659572
12response to methylmercury (GO:0051597)3.84344742
13platelet dense granule organization (GO:0060155)3.83833232
14synaptic vesicle exocytosis (GO:0016079)3.83490883
15regulation of glutamate receptor signaling pathway (GO:1900449)3.79842622
16synaptic vesicle maturation (GO:0016188)3.75501802
17substrate-independent telencephalic tangential migration (GO:0021826)3.74311161
18substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.74311161
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.74177575
20vocalization behavior (GO:0071625)3.73947495
21respiratory chain complex IV assembly (GO:0008535)3.70997520
22long-term memory (GO:0007616)3.70042483
23negative regulation of neurotransmitter transport (GO:0051589)3.66412224
24protein neddylation (GO:0045116)3.62946809
25neuron cell-cell adhesion (GO:0007158)3.62337099
26positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.61078570
27negative regulation of neurotransmitter secretion (GO:0046929)3.59732657
28cytochrome complex assembly (GO:0017004)3.58818289
29positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.55160238
30regulation of synaptic vesicle exocytosis (GO:2000300)3.50328766
31nerve growth factor signaling pathway (GO:0038180)3.47559115
32negative regulation of protein localization to cell surface (GO:2000009)3.46432981
33cerebellar Purkinje cell differentiation (GO:0021702)3.45314300
34presynaptic membrane organization (GO:0097090)3.44995177
35central nervous system myelination (GO:0022010)3.44127845
36axon ensheathment in central nervous system (GO:0032291)3.44127845
37glutamate secretion (GO:0014047)3.42798999
38neuromuscular process controlling posture (GO:0050884)3.41600021
39presynaptic membrane assembly (GO:0097105)3.37416148
40ionotropic glutamate receptor signaling pathway (GO:0035235)3.36586643
41protein localization to synapse (GO:0035418)3.35122167
42organelle disassembly (GO:1903008)3.33697971
43negative regulation of cytosolic calcium ion concentration (GO:0051481)3.33407845
44regulation of inositol phosphate biosynthetic process (GO:0010919)3.33326168
45fatty acid elongation (GO:0030497)3.32454432
46gamma-aminobutyric acid signaling pathway (GO:0007214)3.31750709
47neuron-neuron synaptic transmission (GO:0007270)3.28961326
48glutamate receptor signaling pathway (GO:0007215)3.28659166
49neurotransmitter-gated ion channel clustering (GO:0072578)3.27228095
50gamma-aminobutyric acid transport (GO:0015812)3.25739900
51L-fucose catabolic process (GO:0042355)3.25529663
52fucose catabolic process (GO:0019317)3.25529663
53L-fucose metabolic process (GO:0042354)3.25529663
54synaptic transmission, glutamatergic (GO:0035249)3.25433701
55ubiquinone biosynthetic process (GO:0006744)3.23353288
56water-soluble vitamin biosynthetic process (GO:0042364)3.23349336
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.22736880
58regulation of glucokinase activity (GO:0033131)3.19203256
59regulation of hexokinase activity (GO:1903299)3.19203256
60cellular potassium ion homeostasis (GO:0030007)3.17649702
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.16268719
62inner mitochondrial membrane organization (GO:0007007)3.15718540
63hydrogen ion transmembrane transport (GO:1902600)3.15129791
64protein-cofactor linkage (GO:0018065)3.14625253
65regulation of synaptic vesicle transport (GO:1902803)3.12783815
66synaptic vesicle docking involved in exocytosis (GO:0016081)3.12339170
67mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.12285287
68long-term synaptic potentiation (GO:0060291)3.11347580
69preassembly of GPI anchor in ER membrane (GO:0016254)3.11074619
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.07717196
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.07717196
72regulation of synapse maturation (GO:0090128)3.04653282
73pyrimidine nucleobase catabolic process (GO:0006208)3.04465295
74regulation of voltage-gated calcium channel activity (GO:1901385)3.04018622
75positive regulation of action potential (GO:0045760)3.03897782
76negative regulation of synaptic transmission, GABAergic (GO:0032229)3.03188037
77cullin deneddylation (GO:0010388)3.01828782
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01484502
79regulation of neuronal synaptic plasticity (GO:0048168)3.01075107
80ubiquinone metabolic process (GO:0006743)2.99798038
81proton transport (GO:0015992)2.98369540
82response to pheromone (GO:0019236)2.98180839
83ribonucleoprotein complex disassembly (GO:0032988)2.97539509
84regulation of neurotransmitter secretion (GO:0046928)2.96064003
85ATP biosynthetic process (GO:0006754)2.95952483
86transmission of nerve impulse (GO:0019226)2.95841909
87neurotransmitter transport (GO:0006836)2.95725505
88neurotransmitter secretion (GO:0007269)2.93623506
89hydrogen transport (GO:0006818)2.93146857
90locomotory exploration behavior (GO:0035641)2.92437712
91nonmotile primary cilium assembly (GO:0035058)2.92128405
92protein complex biogenesis (GO:0070271)2.91830654
93mitochondrial respiratory chain complex I assembly (GO:0032981)2.91474040
94NADH dehydrogenase complex assembly (GO:0010257)2.91474040
95mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91474040
96regulation of cell communication by electrical coupling (GO:0010649)2.91202383
97positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.91030326
98negative regulation of telomere maintenance (GO:0032205)2.91015721
99cellular ketone body metabolic process (GO:0046950)2.91013580
100mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.90933025
101regulation of synaptic transmission, glutamatergic (GO:0051966)2.90222499
102nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89299064
103L-amino acid import (GO:0043092)2.89117832
104regulation of excitatory postsynaptic membrane potential (GO:0060079)2.88443527
105neurotransmitter uptake (GO:0001504)2.88363172
106peptidyl-tyrosine autophosphorylation (GO:0038083)2.87472355
107protein deneddylation (GO:0000338)2.86460019
108purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.84427991
109regulation of postsynaptic membrane potential (GO:0060078)2.84272131
110intracellular protein transmembrane import (GO:0044743)2.84258711
111exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83762052
112purine nucleoside triphosphate biosynthetic process (GO:0009145)2.83676823
113protein localization to cilium (GO:0061512)2.82616569
114positive regulation of synapse maturation (GO:0090129)2.81909927
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80824282
116nucleobase catabolic process (GO:0046113)2.80475521
117epithelial cilium movement (GO:0003351)2.79604196
118regulation of neurotransmitter transport (GO:0051588)2.79452521
119calcium ion import (GO:0070509)2.79397599
120intracellular pH reduction (GO:0051452)2.78576133
121neural tube formation (GO:0001841)2.78109765
122membrane depolarization during action potential (GO:0086010)2.77367087
123anterograde synaptic vesicle transport (GO:0048490)2.76595544
124chaperone-mediated protein transport (GO:0072321)2.75826244
125positive regulation of synaptic transmission, GABAergic (GO:0032230)2.75565488
126indolalkylamine metabolic process (GO:0006586)2.74296704
127detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73775622
128regulation of long-term neuronal synaptic plasticity (GO:0048169)2.73203231
129regulation of vesicle fusion (GO:0031338)2.72950124
130adult walking behavior (GO:0007628)2.72584155
131tryptophan catabolic process (GO:0006569)2.72336860
132indole-containing compound catabolic process (GO:0042436)2.72336860
133indolalkylamine catabolic process (GO:0046218)2.72336860
134synaptic transmission, cholinergic (GO:0007271)2.71689739
135epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71444980
136negative regulation of inclusion body assembly (GO:0090084)2.71249127
137kynurenine metabolic process (GO:0070189)2.71078465
138positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.71007980
139regulation of cilium movement (GO:0003352)2.70719391
140proteasome assembly (GO:0043248)2.70121605
141mitochondrial fission (GO:0000266)2.69349232
142ketone body metabolic process (GO:1902224)2.68513782
143calcium ion-dependent exocytosis (GO:0017156)2.67187208
144dopamine transport (GO:0015872)2.65863795
145detection of light stimulus involved in visual perception (GO:0050908)2.65548557
146detection of light stimulus involved in sensory perception (GO:0050962)2.65548557
147response to histamine (GO:0034776)2.65299872
148termination of RNA polymerase III transcription (GO:0006386)2.64672745
149transcription elongation from RNA polymerase III promoter (GO:0006385)2.64672745
150membrane depolarization (GO:0051899)2.62080814
151positive regulation of membrane potential (GO:0045838)2.60371972
152mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.60288015
153L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.59504732
154learning (GO:0007612)2.59218263
155positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.58352926
156negative regulation of heart rate (GO:0010459)2.58033742
157pH reduction (GO:0045851)2.57817904
158piRNA metabolic process (GO:0034587)2.56267682
159respiratory electron transport chain (GO:0022904)2.55750686
160mannosylation (GO:0097502)2.54456225
161regulation of synaptic plasticity (GO:0048167)2.54287248
162GPI anchor metabolic process (GO:0006505)2.53912308
163behavioral response to ethanol (GO:0048149)2.52911627
164peptidyl-histidine modification (GO:0018202)2.50746246
165maturation of 5.8S rRNA (GO:0000460)2.48759183
166protein K6-linked ubiquitination (GO:0085020)2.48233427
167GTP biosynthetic process (GO:0006183)2.47933767
168tRNA processing (GO:0008033)2.47466833
169neuronal action potential (GO:0019228)2.47395625
170single strand break repair (GO:0000012)2.47241660
171quinone biosynthetic process (GO:1901663)2.45730656
172cytidine metabolic process (GO:0046087)2.42618788
173cytidine catabolic process (GO:0006216)2.42618788
174cytidine deamination (GO:0009972)2.42618788
175S-adenosylmethionine metabolic process (GO:0046500)2.42302206
176intraciliary transport (GO:0042073)2.38315877
177tryptophan metabolic process (GO:0006568)2.38144518
178signal peptide processing (GO:0006465)2.37149187
179translational termination (GO:0006415)2.36155551
180C-terminal protein lipidation (GO:0006501)2.34632915
181viral transcription (GO:0019083)2.34194061
182spinal cord motor neuron differentiation (GO:0021522)2.34181421
183cotranslational protein targeting to membrane (GO:0006613)2.33868651
184indole-containing compound metabolic process (GO:0042430)2.33725854
185ribonucleoside triphosphate biosynthetic process (GO:0009201)2.33435016
186negative regulation of transcription regulatory region DNA binding (GO:2000678)2.32110987
187axoneme assembly (GO:0035082)2.31340430
188SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.31088374
189DNA double-strand break processing (GO:0000729)2.31037588

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.94982045
2EZH2_22144423_ChIP-Seq_EOC_Human3.61873209
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.52343278
4ZNF274_21170338_ChIP-Seq_K562_Hela3.43724558
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22715940
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.15719395
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.94401148
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94151612
9VDR_22108803_ChIP-Seq_LS180_Human2.88152138
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.79107296
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62911896
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.49085618
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46623410
14REST_21632747_ChIP-Seq_MESCs_Mouse2.43241020
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.41182490
16TAF15_26573619_Chip-Seq_HEK293_Human2.35826726
17AR_21572438_ChIP-Seq_LNCaP_Human2.33904535
18ELK1_19687146_ChIP-ChIP_HELA_Human2.11173542
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05156779
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04402365
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00679171
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99262759
23DROSHA_22980978_ChIP-Seq_HELA_Human1.95853014
24VDR_23849224_ChIP-Seq_CD4+_Human1.93261535
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.92926693
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91619453
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.91303460
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.89550747
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88680868
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88306896
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86709011
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.86673788
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86461923
34MYC_18940864_ChIP-ChIP_HL60_Human1.86267966
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.85920980
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83772714
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81254709
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80873169
39P300_19829295_ChIP-Seq_ESCs_Human1.80438188
40SMAD4_21799915_ChIP-Seq_A2780_Human1.79838306
41FUS_26573619_Chip-Seq_HEK293_Human1.78375510
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77026013
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76745151
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74242540
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73900850
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.72882410
47ER_23166858_ChIP-Seq_MCF-7_Human1.72646998
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71498331
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70070376
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69476830
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.67087426
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62100271
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62100271
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58889484
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57246186
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.56371781
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.55558328
58TP53_22573176_ChIP-Seq_HFKS_Human1.54083999
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.53626344
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52528043
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.49416081
62IRF1_19129219_ChIP-ChIP_H3396_Human1.46338857
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45081956
64CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43905206
65AR_25329375_ChIP-Seq_VCAP_Human1.43526014
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41455980
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38931560
68ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37544507
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.36283976
70* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34848752
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34286292
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34011196
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.32523513
74* FOXP3_21729870_ChIP-Seq_TREG_Human1.29693442
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.28851775
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28851775
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27933605
78MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.27838583
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27590209
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27127216
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27127216
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.25407328
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.22616251
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.22456244
85E2F1_18555785_Chip-Seq_ESCs_Mouse1.22307828
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22161558
87* STAT3_18555785_Chip-Seq_ESCs_Mouse1.21354150
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20599305
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20283411
90CBP_20019798_ChIP-Seq_JUKART_Human1.20283411
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18884114
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18697104
93* P300_18555785_Chip-Seq_ESCs_Mouse1.17957247
94* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.17690825
95* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17065502
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16627223
97RNF2_27304074_Chip-Seq_ESCs_Mouse1.15752394
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15133925
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14985963
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14978892
101* P53_22387025_ChIP-Seq_ESCs_Mouse1.14240545
102PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14146244
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13321818
104TCF4_23295773_ChIP-Seq_U87_Human1.13155801
105PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13080545
106* CMYC_18555785_Chip-Seq_ESCs_Mouse1.13029583
107STAT3_23295773_ChIP-Seq_U87_Human1.12875259
108RNF2_27304074_Chip-Seq_NSC_Mouse1.12384062
109POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11935052
110SOX2_19829295_ChIP-Seq_ESCs_Human1.11928303
111NANOG_19829295_ChIP-Seq_ESCs_Human1.11928303
112* SOX2_18555785_Chip-Seq_ESCs_Mouse1.11137243
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10820150
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10489745
115BCAT_22108803_ChIP-Seq_LS180_Human1.10237013
116AR_20517297_ChIP-Seq_VCAP_Human1.10055899
117FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09028746
118NCOR_22424771_ChIP-Seq_293T_Human1.09015216
119NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08049770
120PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07840947
121CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06675177
122* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06600374
123CBX2_27304074_Chip-Seq_ESCs_Mouse1.05880028
124TAL1_26923725_Chip-Seq_HPCs_Mouse1.05777972
125SMAD4_21741376_ChIP-Seq_EPCs_Human1.05571334
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05043864
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04159735
128* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03536525
129* KLF4_18555785_Chip-Seq_ESCs_Mouse1.03035398
130GATA3_21878914_ChIP-Seq_MCF-7_Human1.02162015
131PRDM14_20953172_ChIP-Seq_ESCs_Human1.02009788
132* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01878058
133SOX2_21211035_ChIP-Seq_LN229_Gbm1.01833228
134PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01265594
135RUNX2_22187159_ChIP-Seq_PCA_Human1.01156542
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98750537
137ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98691586
138* CRX_20693478_ChIP-Seq_RETINA_Mouse0.98131199
139P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97771378
140KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.97627734
141* PU1_27457419_Chip-Seq_LIVER_Mouse0.97501512
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96920307
143* OCT4_18555785_Chip-Seq_ESCs_Mouse0.96712661
144IGF1R_20145208_ChIP-Seq_DFB_Human0.96454877
145* NMYC_18555785_Chip-Seq_ESCs_Mouse0.96437737
146GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95909260
147HTT_18923047_ChIP-ChIP_STHdh_Human0.95768941
148NFE2_27457419_Chip-Seq_LIVER_Mouse0.95272525
149EWS_26573619_Chip-Seq_HEK293_Human0.94479475

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.44030809
2MP0004859_abnormal_synaptic_plasticity4.11168762
3MP0009046_muscle_twitch3.20947283
4MP0002064_seizures3.09436029
5MP0003635_abnormal_synaptic_transmissio3.08634861
6MP0009745_abnormal_behavioral_response2.99577485
7MP0002272_abnormal_nervous_system2.92279899
8MP0004147_increased_porphyrin_level2.77541126
9MP0001968_abnormal_touch/_nociception2.61374242
10MP0002102_abnormal_ear_morphology2.60864402
11MP0002572_abnormal_emotion/affect_behav2.52049461
12MP0002063_abnormal_learning/memory/cond2.39441386
13MP0003195_calcinosis2.36282717
14MP0001486_abnormal_startle_reflex2.31369789
15MP0003646_muscle_fatigue2.18369329
16MP0005646_abnormal_pituitary_gland2.16551654
17MP0001501_abnormal_sleep_pattern2.12432524
18MP0002735_abnormal_chemical_nociception2.11107664
19MP0005551_abnormal_eye_electrophysiolog2.08999577
20MP0000920_abnormal_myelination2.05695694
21MP0002638_abnormal_pupillary_reflex2.04039633
22MP0002736_abnormal_nociception_after1.99435538
23MP0000372_irregular_coat_pigmentation1.99139831
24MP0001905_abnormal_dopamine_level1.99122541
25MP0005423_abnormal_somatic_nervous1.98445833
26MP0002822_catalepsy1.98129077
27MP0001440_abnormal_grooming_behavior1.95045317
28MP0008058_abnormal_DNA_repair1.94224281
29MP0005410_abnormal_fertilization1.88279690
30MP0008569_lethality_at_weaning1.82983561
31MP0001529_abnormal_vocalization1.82024550
32MP0004142_abnormal_muscle_tone1.81487747
33MP0002067_abnormal_sensory_capabilities1.79446521
34MP0004145_abnormal_muscle_electrophysio1.79116640
35MP0003787_abnormal_imprinting1.78045765
36MP0004270_analgesia1.72116261
37MP0002653_abnormal_ependyma_morphology1.72088190
38MP0000569_abnormal_digit_pigmentation1.70835992
39MP0005084_abnormal_gallbladder_morpholo1.68004972
40MP0003690_abnormal_glial_cell1.67035956
41MP0008872_abnormal_physiological_respon1.66662201
42MP0001970_abnormal_pain_threshold1.66220301
43MP0002734_abnormal_mechanical_nocicepti1.65573707
44MP0005171_absent_coat_pigmentation1.63310813
45MP0002163_abnormal_gland_morphology1.62352081
46MP0000631_abnormal_neuroendocrine_gland1.58200042
47MP0010386_abnormal_urinary_bladder1.55084359
48MP0004484_altered_response_of1.54168405
49MP0003879_abnormal_hair_cell1.54148829
50MP0002733_abnormal_thermal_nociception1.53961248
51MP0004215_abnormal_myocardial_fiber1.53865626
52MP0001188_hyperpigmentation1.49947399
53MP0002938_white_spotting1.48845368
54MP0003633_abnormal_nervous_system1.48444248
55MP0002090_abnormal_vision1.47225553
56MP0004036_abnormal_muscle_relaxation1.46486001
57MP0002229_neurodegeneration1.45532623
58MP0000749_muscle_degeneration1.44504316
59MP0000751_myopathy1.41878934
60MP0004084_abnormal_cardiac_muscle1.41269438
61MP0005386_behavior/neurological_phenoty1.40340504
62MP0004924_abnormal_behavior1.40340504
63MP0002277_abnormal_respiratory_mucosa1.38825397
64MP0006036_abnormal_mitochondrial_physio1.37703640
65MP0002876_abnormal_thyroid_physiology1.36671387
66MP0005379_endocrine/exocrine_gland_phen1.35708604
67MP0002837_dystrophic_cardiac_calcinosis1.31620956
68MP0001485_abnormal_pinna_reflex1.28402392
69MP0003011_delayed_dark_adaptation1.27636460
70MP0002557_abnormal_social/conspecific_i1.27259426
71MP0004742_abnormal_vestibular_system1.25467622
72MP0003656_abnormal_erythrocyte_physiolo1.24767127
73MP0003631_nervous_system_phenotype1.24658035
74MP0008260_abnormal_autophagy1.24163187
75MP0001986_abnormal_taste_sensitivity1.23461934
76MP0001502_abnormal_circadian_rhythm1.22962655
77MP0003172_abnormal_lysosome_physiology1.22470797
78MP0003950_abnormal_plasma_membrane1.21316154
79MP0008995_early_reproductive_senescence1.21101055
80MP0002066_abnormal_motor_capabilities/c1.19888199
81MP0005174_abnormal_tail_pigmentation1.19572055
82MP0004133_heterotaxia1.17940096
83MP0008875_abnormal_xenobiotic_pharmacok1.16841546
84MP0004885_abnormal_endolymph1.16659011
85MP0001963_abnormal_hearing_physiology1.16433016
86MP0002234_abnormal_pharynx_morphology1.16343197
87MP0002882_abnormal_neuron_morphology1.15502638
88MP0005535_abnormal_body_temperature1.15050772
89MP0005075_abnormal_melanosome_morpholog1.14232568
90MP0006276_abnormal_autonomic_nervous1.13473090
91MP0003718_maternal_effect1.10685424
92MP0002095_abnormal_skin_pigmentation1.09584000
93MP0002751_abnormal_autonomic_nervous1.08436696
94MP0003329_amyloid_beta_deposits1.08425824
95MP0003186_abnormal_redox_activity1.07961829
96MP0006072_abnormal_retinal_apoptosis1.07231014
97MP0002160_abnormal_reproductive_system1.06483166
98MP0003121_genomic_imprinting1.06041203
99MP0002928_abnormal_bile_duct1.05507929
100MP0005645_abnormal_hypothalamus_physiol1.05146203
101MP0001324_abnormal_eye_pigmentation1.04879020
102MP0006035_abnormal_mitochondrial_morpho1.03082646
103MP0004043_abnormal_pH_regulation1.02991974
104MP0005389_reproductive_system_phenotype1.02515366
105MP0003122_maternal_imprinting0.99355215
106MP0005253_abnormal_eye_physiology0.98877128
107MP0000747_muscle_weakness0.98229596
108MP0001984_abnormal_olfaction0.97693614
109MP0008789_abnormal_olfactory_epithelium0.96891853
110MP0008775_abnormal_heart_ventricle0.96827005
111MP0005332_abnormal_amino_acid0.96045251
112MP0001919_abnormal_reproductive_system0.94726785
113MP0000778_abnormal_nervous_system0.94484686
114MP0002909_abnormal_adrenal_gland0.94294751
115MP0000427_abnormal_hair_cycle0.93676478
116MP0003634_abnormal_glial_cell0.93600926
117MP0004085_abnormal_heartbeat0.92950737
118MP0002184_abnormal_innervation0.92893059
119MP0003137_abnormal_impulse_conducting0.92862875
120MP0006292_abnormal_olfactory_placode0.92212447
121MP0009384_cardiac_valve_regurgitation0.91946084
122MP0009697_abnormal_copulation0.91852352
123MP0005195_abnormal_posterior_eye0.90031398
124MP0003632_abnormal_nervous_system0.87199537
125MP0003786_premature_aging0.86194927
126MP0009379_abnormal_foot_pigmentation0.85198291
127MP0001764_abnormal_homeostasis0.83189567
128MP0003698_abnormal_male_reproductive0.81798781
129MP0002693_abnormal_pancreas_physiology0.81482685
130MP0001929_abnormal_gametogenesis0.80270808
131MP0009780_abnormal_chondrocyte_physiolo0.80197111
132MP0002752_abnormal_somatic_nervous0.79498715
133MP0003806_abnormal_nucleotide_metabolis0.78717665
134MP0002332_abnormal_exercise_endurance0.78663889
135MP0005330_cardiomyopathy0.77548427
136MP0004811_abnormal_neuron_physiology0.77379419
137MP0003136_yellow_coat_color0.76903099
138MP0001346_abnormal_lacrimal_gland0.76716432
139MP0008877_abnormal_DNA_methylation0.75324623
140MP0005409_darkened_coat_color0.74905128
141MP0008874_decreased_physiological_sensi0.74682088
142MP0003183_abnormal_peptide_metabolism0.74153814
143MP0005595_abnormal_vascular_smooth0.70278157
144MP0000955_abnormal_spinal_cord0.69855767
145MP0005620_abnormal_muscle_contractility0.68068299

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.66271156
2Myokymia (HP:0002411)4.86893372
3Epileptic encephalopathy (HP:0200134)4.65837997
4Acute necrotizing encephalopathy (HP:0006965)4.02972388
5Progressive cerebellar ataxia (HP:0002073)3.87947973
6Central scotoma (HP:0000603)3.69555568
7Abnormal mitochondria in muscle tissue (HP:0008316)3.66355691
8Pancreatic cysts (HP:0001737)3.65343223
9Acute encephalopathy (HP:0006846)3.53358790
10Mitochondrial inheritance (HP:0001427)3.36253226
11Progressive macrocephaly (HP:0004481)3.30682659
12Pancreatic fibrosis (HP:0100732)3.23017453
13Focal seizures (HP:0007359)3.20167185
14True hermaphroditism (HP:0010459)3.19017751
15Hepatocellular necrosis (HP:0001404)3.12928898
16Increased CSF lactate (HP:0002490)3.10258153
17Hyperventilation (HP:0002883)3.09232458
18Nephronophthisis (HP:0000090)2.97190789
19Atonic seizures (HP:0010819)2.96196488
20Scotoma (HP:0000575)2.94919995
21Abnormality of macular pigmentation (HP:0008002)2.91479922
223-Methylglutaconic aciduria (HP:0003535)2.88545315
23Abnormality of glycolysis (HP:0004366)2.87582721
24Increased serum pyruvate (HP:0003542)2.87582721
25Febrile seizures (HP:0002373)2.82065806
26Congenital stationary night blindness (HP:0007642)2.80971077
27Dysmetria (HP:0001310)2.80319908
28Absent/shortened dynein arms (HP:0200106)2.79313740
29Dynein arm defect of respiratory motile cilia (HP:0012255)2.79313740
30Optic disc pallor (HP:0000543)2.73637632
31Septo-optic dysplasia (HP:0100842)2.70069012
32Hepatic necrosis (HP:0002605)2.65974502
33Hypothermia (HP:0002045)2.63723721
34Visual hallucinations (HP:0002367)2.62982829
35Leukodystrophy (HP:0002415)2.62299528
36Abnormality of binocular vision (HP:0011514)2.57289648
37Diplopia (HP:0000651)2.57289648
38Dysdiadochokinesis (HP:0002075)2.55075050
39Large for gestational age (HP:0001520)2.54563349
40Increased hepatocellular lipid droplets (HP:0006565)2.54410529
41Lipid accumulation in hepatocytes (HP:0006561)2.53657827
42Gaze-evoked nystagmus (HP:0000640)2.51269880
43Methylmalonic acidemia (HP:0002912)2.50230603
44Broad-based gait (HP:0002136)2.49592022
45Scanning speech (HP:0002168)2.47697833
46Absent septum pellucidum (HP:0001331)2.46256012
47Neuroendocrine neoplasm (HP:0100634)2.45944575
48Microvesicular hepatic steatosis (HP:0001414)2.45001237
49Nephrogenic diabetes insipidus (HP:0009806)2.42166798
50Action tremor (HP:0002345)2.39430785
51Abnormality of the renal medulla (HP:0100957)2.39339052
52Renal Fanconi syndrome (HP:0001994)2.37367272
53Gait imbalance (HP:0002141)2.32306298
54Lactic acidosis (HP:0003128)2.29649627
55Dialeptic seizures (HP:0011146)2.29409686
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.27293377
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.27293377
58Type II lissencephaly (HP:0007260)2.27174045
59Congenital primary aphakia (HP:0007707)2.27149146
60Abnormality of the renal cortex (HP:0011035)2.25340639
61Increased intramyocellular lipid droplets (HP:0012240)2.25086930
62Anxiety (HP:0000739)2.24097714
63Progressive inability to walk (HP:0002505)2.23783743
64Abnormal number of erythroid precursors (HP:0012131)2.23375637
65Exertional dyspnea (HP:0002875)2.20081074
66Cerebral edema (HP:0002181)2.20052916
67Abnormality of the septum pellucidum (HP:0007375)2.19483440
68Ketoacidosis (HP:0001993)2.19428335
69Absence seizures (HP:0002121)2.19209691
70Generalized tonic-clonic seizures (HP:0002069)2.19093448
71Cerebral hypomyelination (HP:0006808)2.18402021
72Medial flaring of the eyebrow (HP:0010747)2.18151741
73Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.17602367
74Abnormal rod and cone electroretinograms (HP:0008323)2.17017915
75Abnormal hair whorl (HP:0010721)2.16529570
76Sensory axonal neuropathy (HP:0003390)2.14499028
77Attenuation of retinal blood vessels (HP:0007843)2.13740000
78Increased muscle lipid content (HP:0009058)2.12866083
79Pheochromocytoma (HP:0002666)2.12465870
80Poor coordination (HP:0002370)2.12050370
81Hyperglycinemia (HP:0002154)2.11533763
82Abolished electroretinogram (ERG) (HP:0000550)2.10829453
83Lethargy (HP:0001254)2.10340400
84Congenital, generalized hypertrichosis (HP:0004540)2.10244484
85Abnormality of cells of the erythroid lineage (HP:0012130)2.07128584
86Colon cancer (HP:0003003)2.06974085
87Methylmalonic aciduria (HP:0012120)2.06704318
88Birth length less than 3rd percentile (HP:0003561)2.06380235
89Exercise intolerance (HP:0003546)2.06067630
90Increased serum lactate (HP:0002151)2.05517990
91Renal cortical cysts (HP:0000803)2.05304422
92Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.04356766
93Sclerocornea (HP:0000647)2.03840858
94Cerebral hemorrhage (HP:0001342)2.02701287
95Postural instability (HP:0002172)2.01050710
96Abnormality of alanine metabolism (HP:0010916)2.00961764
97Hyperalaninemia (HP:0003348)2.00961764
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00961764
99Exercise-induced muscle cramps (HP:0003710)2.00333270
100Abnormality of the columella (HP:0009929)2.00159335
101Confusion (HP:0001289)1.99889511
102Neurofibrillary tangles (HP:0002185)1.99444377
103Peripheral hypomyelination (HP:0007182)1.98535292
104Poor eye contact (HP:0000817)1.98220300
105Cortical visual impairment (HP:0100704)1.97736970
106Inability to walk (HP:0002540)1.97478271
107Hemiparesis (HP:0001269)1.97261827
108Abnormality of the labia minora (HP:0012880)1.96757608
109Pendular nystagmus (HP:0012043)1.96281226
110Hypomagnesemia (HP:0002917)1.95793211
111Limb dystonia (HP:0002451)1.94366897
112White forelock (HP:0002211)1.93550224
113Respiratory difficulties (HP:0002880)1.93369708
114Onion bulb formation (HP:0003383)1.92997013
115Ketosis (HP:0001946)1.92182227
116Genital tract atresia (HP:0001827)1.91980453
117Respiratory failure (HP:0002878)1.91489635
118Abnormal gallbladder physiology (HP:0012438)1.91435676
119Cholecystitis (HP:0001082)1.91435676
120Abnormal drinking behavior (HP:0030082)1.90951495
121Polydipsia (HP:0001959)1.90951495
122Constricted visual fields (HP:0001133)1.90678979
123Delusions (HP:0000746)1.90124638
124Abnormal ciliary motility (HP:0012262)1.90097626
125Anencephaly (HP:0002323)1.89288753
126Molar tooth sign on MRI (HP:0002419)1.88641874
127Abnormality of midbrain morphology (HP:0002418)1.88641874
128Nonprogressive disorder (HP:0003680)1.88457352
129Patchy hypopigmentation of hair (HP:0011365)1.87871330
130Vaginal atresia (HP:0000148)1.87717208
131Lissencephaly (HP:0001339)1.87556852
132Poor speech (HP:0002465)1.87146555
133Cystic liver disease (HP:0006706)1.86515891
134Abnormality of renal resorption (HP:0011038)1.85410789
135Focal dystonia (HP:0004373)1.85096238
136Glycosuria (HP:0003076)1.84977498
137Abnormality of urine glucose concentration (HP:0011016)1.84977498
138Male pseudohermaphroditism (HP:0000037)1.84498308
139Abnormal respiratory motile cilium morphology (HP:0005938)1.84075837
140Abnormal respiratory epithelium morphology (HP:0012253)1.84075837
141Furrowed tongue (HP:0000221)1.82803923
142Aplasia/hypoplasia of the uterus (HP:0008684)1.82219725
143Chronic hepatic failure (HP:0100626)1.81069082
144Abnormality of serum amino acid levels (HP:0003112)1.80741399
145Hyperglycinuria (HP:0003108)1.78505319
146Intestinal atresia (HP:0011100)1.74301901
147Reticulocytopenia (HP:0001896)1.72929105
148Pachygyria (HP:0001302)1.69162567
149Abnormality of the pons (HP:0007361)1.68461987
150Decreased electroretinogram (ERG) amplitude (HP:0000654)1.67229364
151Generalized aminoaciduria (HP:0002909)1.67208772
152Abnormal respiratory motile cilium physiology (HP:0012261)1.66564066
153Abnormality of the fovea (HP:0000493)1.65857891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.92917047
2FRK3.62783660
3MAP4K23.44202138
4SIK32.80119596
5ZAK2.73453013
6ADRBK22.70545142
7WNK32.55363018
8PRPF4B2.54067117
9EPHA42.46147962
10NTRK32.39880264
11NUAK12.37385905
12PDK42.23836641
13PDK32.23836641
14TLK12.21071509
15STK162.18835273
16MAP3K122.14632964
17PINK12.09689643
18MAPKAPK52.04568047
19MST42.02415998
20PNCK1.98465101
21DAPK21.88766416
22CCNB11.88405690
23WNK41.85747841
24TRIM281.82921122
25MAP3K131.80870642
26OXSR11.77113109
27MARK11.75186770
28PDK21.73526401
29TSSK61.69342667
30TNIK1.63397698
31VRK21.62524443
32CDK191.61902988
33MAP2K71.54379463
34MAP3K41.44856181
35STK391.44769474
36DYRK21.42244847
37PAK61.36359007
38GRK71.34953159
39TAOK31.31965780
40VRK11.29243245
41NTRK21.28138457
42CAMKK21.28003835
43WNK11.26223935
44SIK21.25988645
45MARK31.23821039
46BRD41.19989391
47ERBB31.19784008
48ARAF1.19528352
49BRSK21.16158551
50MAP2K41.13211145
51MAPK151.12970139
52EIF2AK31.09801936
53BUB11.08937911
54TAF11.08325378
55PRKCG1.07868193
56PAK31.07280333
57PLK31.06051206
58PASK1.06041002
59SGK4941.03107305
60SGK2231.03107305
61CAMK2A1.02823513
62MINK11.02312369
63CAMK2B1.01856418
64TXK1.01852858
65PTK2B0.99908833
66NEK10.98765970
67PLK40.95775446
68NTRK10.94733916
69CSNK1G20.93529154
70CSNK1G30.92641037
71NEK60.92422471
72TYRO30.91125835
73TYK20.88659716
74PKN10.88087022
75WEE10.87744904
76CDK50.86608037
77BMPR1B0.86558072
78MAP3K90.85466651
79CDK30.85166024
80MKNK20.84694140
81FLT30.84169955
82PHKG20.83989693
83PHKG10.83989693
84GRK50.83491469
85ROCK20.82716308
86PRKCE0.82360545
87CSNK1G10.81772242
88SRPK10.81761677
89ADRBK10.78315441
90CAMK2G0.78157243
91MARK20.73442028
92RPS6KA50.72377346
93INSRR0.72323997
94TGFBR10.71745683
95KIT0.70901820
96PLK20.70358414
97DYRK30.69609067
98DDR20.68488860
99TEC0.67665569
100CAMK2D0.66429143
101MAPK130.66001273
102CSNK1A1L0.62330491
103TIE10.60099560
104MYLK0.59280438
105TAOK20.58828814
106SIK10.58068145
107UHMK10.56377627
108ALK0.54801451
109MAP2K60.54691962
110FES0.54460973
111BRSK10.53808316
112CAMK10.53436119
113MKNK10.51993778
114MAPK70.51946353
115DAPK10.51598190
116CDC70.51264939
117BMPR20.50205709
118SGK20.49855537
119LIMK10.49850797
120ACVR1B0.49526667
121GRK10.49472132
122CDK180.48728635
123PLK10.48703038
124BCR0.48622036
125CDK140.47978315
126IRAK10.47638149
127PIK3CA0.47568037
128NME10.47523140
129RIPK40.47039608
130PRKACA0.45944752
131BCKDK0.45829997
132CDK150.44180373
133CDC42BPA0.43977187
134PRKACB0.43910571
135PRKG10.43209640
136YES10.42906626
137OBSCN0.42699860
138STK110.42415520
139EPHB10.40225654
140PRKCQ0.39734787
141IKBKB0.35773454
142CSNK2A20.35612105
143CSNK2A10.34298329
144DYRK1A0.33243173
145CSNK1A10.33004633
146PRKCI0.31876353
147ATR0.31540865
148RPS6KA40.31154130

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.55004459
2Ribosome_Homo sapiens_hsa030102.76452987
3Synaptic vesicle cycle_Homo sapiens_hsa047212.69263184
4Oxidative phosphorylation_Homo sapiens_hsa001902.61594920
5Morphine addiction_Homo sapiens_hsa050322.54893594
6GABAergic synapse_Homo sapiens_hsa047272.49119127
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.44595008
8Vitamin B6 metabolism_Homo sapiens_hsa007502.37507052
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.30671540
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.20744181
11Circadian entrainment_Homo sapiens_hsa047132.19597689
12Glutamatergic synapse_Homo sapiens_hsa047242.10273238
13Collecting duct acid secretion_Homo sapiens_hsa049662.07323517
14RNA polymerase_Homo sapiens_hsa030202.04974240
15Proteasome_Homo sapiens_hsa030502.04767903
16Fatty acid elongation_Homo sapiens_hsa000622.03920990
17Amphetamine addiction_Homo sapiens_hsa050311.91476856
18Homologous recombination_Homo sapiens_hsa034401.88041173
19Cardiac muscle contraction_Homo sapiens_hsa042601.81117350
20Parkinsons disease_Homo sapiens_hsa050121.76790207
21Linoleic acid metabolism_Homo sapiens_hsa005911.75618695
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72569829
23Phototransduction_Homo sapiens_hsa047441.71829896
24Basal transcription factors_Homo sapiens_hsa030221.71436574
25Salivary secretion_Homo sapiens_hsa049701.71199795
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66264379
27Insulin secretion_Homo sapiens_hsa049111.65758046
28Calcium signaling pathway_Homo sapiens_hsa040201.65113874
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.64830938
30Serotonergic synapse_Homo sapiens_hsa047261.63569393
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.63396686
32Alzheimers disease_Homo sapiens_hsa050101.61587157
33Fanconi anemia pathway_Homo sapiens_hsa034601.57284588
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55582194
35Olfactory transduction_Homo sapiens_hsa047401.52662115
36Long-term potentiation_Homo sapiens_hsa047201.51336354
37Gastric acid secretion_Homo sapiens_hsa049711.45048281
38Selenocompound metabolism_Homo sapiens_hsa004501.43259888
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38036693
40Propanoate metabolism_Homo sapiens_hsa006401.31852979
41Tryptophan metabolism_Homo sapiens_hsa003801.31540925
42Caffeine metabolism_Homo sapiens_hsa002321.31370465
43Renin secretion_Homo sapiens_hsa049241.29686946
44RNA degradation_Homo sapiens_hsa030181.29192405
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27098456
46One carbon pool by folate_Homo sapiens_hsa006701.22254146
47Dopaminergic synapse_Homo sapiens_hsa047281.21320948
48Oxytocin signaling pathway_Homo sapiens_hsa049211.20852655
49Huntingtons disease_Homo sapiens_hsa050161.14324532
50Taste transduction_Homo sapiens_hsa047421.13920028
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12822483
52Pyruvate metabolism_Homo sapiens_hsa006201.12298968
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11380894
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10079399
55Vibrio cholerae infection_Homo sapiens_hsa051101.10024685
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08045199
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07862974
58Peroxisome_Homo sapiens_hsa041461.07527927
59Cocaine addiction_Homo sapiens_hsa050301.07270098
60Cholinergic synapse_Homo sapiens_hsa047251.04235291
61Mismatch repair_Homo sapiens_hsa034301.03815122
62Long-term depression_Homo sapiens_hsa047301.01227115
63Type I diabetes mellitus_Homo sapiens_hsa049401.01109503
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00481075
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98750683
66Asthma_Homo sapiens_hsa053100.98603484
67Arginine biosynthesis_Homo sapiens_hsa002200.98566563
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94109686
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93477893
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.93337035
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91847318
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90015656
73Circadian rhythm_Homo sapiens_hsa047100.87877090
74Tyrosine metabolism_Homo sapiens_hsa003500.86863457
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85701991
76Nucleotide excision repair_Homo sapiens_hsa034200.83675028
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83444470
78Regulation of autophagy_Homo sapiens_hsa041400.82880682
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81376027
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80827831
81Pyrimidine metabolism_Homo sapiens_hsa002400.78752030
82Carbon metabolism_Homo sapiens_hsa012000.78610140
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.78194004
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78165681
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76917015
86Non-homologous end-joining_Homo sapiens_hsa034500.76757305
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74791253
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.73476948
89Phenylalanine metabolism_Homo sapiens_hsa003600.73393452
90Steroid biosynthesis_Homo sapiens_hsa001000.73008250
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72179137
92Sulfur metabolism_Homo sapiens_hsa009200.70746034
93cAMP signaling pathway_Homo sapiens_hsa040240.70705442
94Ether lipid metabolism_Homo sapiens_hsa005650.70565899
95Pancreatic secretion_Homo sapiens_hsa049720.70272020
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.69781258
97Rheumatoid arthritis_Homo sapiens_hsa053230.68471490
98Fatty acid metabolism_Homo sapiens_hsa012120.68339195
99Dilated cardiomyopathy_Homo sapiens_hsa054140.67322231
100RNA transport_Homo sapiens_hsa030130.66645179
101Protein export_Homo sapiens_hsa030600.66423126
102Biosynthesis of amino acids_Homo sapiens_hsa012300.66408011
103Folate biosynthesis_Homo sapiens_hsa007900.66314625
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65445485
105Sphingolipid metabolism_Homo sapiens_hsa006000.65048597
106Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64873893
107Chemical carcinogenesis_Homo sapiens_hsa052040.64821025
108Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64009540
109Autoimmune thyroid disease_Homo sapiens_hsa053200.63460159
110Fatty acid degradation_Homo sapiens_hsa000710.63027440
111Ovarian steroidogenesis_Homo sapiens_hsa049130.61982238
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60444960
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60388361
114Allograft rejection_Homo sapiens_hsa053300.60082310
115Spliceosome_Homo sapiens_hsa030400.59897348
116Arachidonic acid metabolism_Homo sapiens_hsa005900.57996889
117Glucagon signaling pathway_Homo sapiens_hsa049220.57814257
118Graft-versus-host disease_Homo sapiens_hsa053320.57390075
119Base excision repair_Homo sapiens_hsa034100.55612731
120Retinol metabolism_Homo sapiens_hsa008300.55578431
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54540850
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.54412598
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54084950
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52641380
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51907905
126Sulfur relay system_Homo sapiens_hsa041220.49943384
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49892657
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48889473
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48813762
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48809879
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48050497
132Metabolic pathways_Homo sapiens_hsa011000.46906898
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46222106
134Purine metabolism_Homo sapiens_hsa002300.44900666
135Histidine metabolism_Homo sapiens_hsa003400.44373091
136Butanoate metabolism_Homo sapiens_hsa006500.43460566
137GnRH signaling pathway_Homo sapiens_hsa049120.42077266
138Primary bile acid biosynthesis_Homo sapiens_hsa001200.40217159
139Nitrogen metabolism_Homo sapiens_hsa009100.38864756
140beta-Alanine metabolism_Homo sapiens_hsa004100.36684223
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35294781
142Glutathione metabolism_Homo sapiens_hsa004800.33621338
143Primary immunodeficiency_Homo sapiens_hsa053400.32369472

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