TAS2R42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fucose catabolic process (GO:0019317)6.79140231
2L-fucose metabolic process (GO:0042354)6.79140231
3L-fucose catabolic process (GO:0042355)6.79140231
4negative regulation of execution phase of apoptosis (GO:1900118)6.65481060
5positive regulation of monocyte chemotaxis (GO:0090026)6.26201112
6positive regulation of T cell chemotaxis (GO:0010820)6.17161374
7regulation of T cell chemotaxis (GO:0010819)6.17161374
8lymphocyte chemotaxis (GO:0048247)6.04569720
9glucosamine-containing compound catabolic process (GO:1901072)5.71983125
10positive regulation of developmental pigmentation (GO:0048087)5.31444163
11cytidine metabolic process (GO:0046087)5.31202134
12cytidine catabolic process (GO:0006216)5.31202134
13cytidine deamination (GO:0009972)5.31202134
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.10715470
15lymphocyte migration (GO:0072676)5.08639572
16branched-chain amino acid catabolic process (GO:0009083)4.84790868
17positive regulation of amino acid transport (GO:0051957)4.81047490
18DNA deamination (GO:0045006)4.73655624
19positive regulation of cAMP-mediated signaling (GO:0043950)4.65496614
20pyrimidine ribonucleoside catabolic process (GO:0046133)4.58762657
21protein K6-linked ubiquitination (GO:0085020)4.42690939
22male meiosis I (GO:0007141)4.38266757
23positive regulation of T cell migration (GO:2000406)4.31433656
24positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.15234622
25regulation of pigment cell differentiation (GO:0050932)4.10240965
26regulation of monocyte chemotaxis (GO:0090025)4.09034873
27regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.08524043
28positive regulation of alpha-beta T cell proliferation (GO:0046641)4.08095892
29nucleoside diphosphate catabolic process (GO:0009134)4.01376351
30branching involved in prostate gland morphogenesis (GO:0060442)3.96617901
31negative regulation of type 2 immune response (GO:0002829)3.84636739
32intestinal cholesterol absorption (GO:0030299)3.78216495
33fucose metabolic process (GO:0006004)3.78099187
34regulation of oxidative phosphorylation (GO:0002082)3.75532246
35regulation of double-strand break repair via homologous recombination (GO:0010569)3.72124554
36meiosis I (GO:0007127)3.65594141
37regulation of lymphocyte chemotaxis (GO:1901623)3.65126133
38cellular ketone body metabolic process (GO:0046950)3.62010462
39branched-chain amino acid metabolic process (GO:0009081)3.60931087
40fucosylation (GO:0036065)3.59908038
41regulation of alpha-beta T cell proliferation (GO:0046640)3.57449913
42positive regulation of lymphocyte migration (GO:2000403)3.54823504
43positive regulation of megakaryocyte differentiation (GO:0045654)3.54079822
44regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.51159023
45regulation of T cell migration (GO:2000404)3.49850635
46positive regulation of uterine smooth muscle contraction (GO:0070474)3.37206174
47positive regulation of T-helper 1 type immune response (GO:0002827)3.36420650
48positive regulation of interleukin-8 secretion (GO:2000484)3.35625915
49regulation of acyl-CoA biosynthetic process (GO:0050812)3.29110521
50negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.26750964
51preassembly of GPI anchor in ER membrane (GO:0016254)3.26438489
52chemokine-mediated signaling pathway (GO:0070098)3.22585826
53ketone body metabolic process (GO:1902224)3.19044153
54dendritic cell chemotaxis (GO:0002407)3.17670567
55histone mRNA catabolic process (GO:0071044)3.11563588
56regulation of cellular extravasation (GO:0002691)3.07431546
57S-adenosylmethionine metabolic process (GO:0046500)3.07385071
58prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.07036739
59protein complex biogenesis (GO:0070271)3.05842602
60GPI anchor metabolic process (GO:0006505)3.04084468
61very-low-density lipoprotein particle assembly (GO:0034379)3.03085758
62regulation of cofactor metabolic process (GO:0051193)3.02981135
63regulation of coenzyme metabolic process (GO:0051196)3.02981135
64positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.00867393
65negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.00168002
66platelet dense granule organization (GO:0060155)2.97969727
67mitochondrial respiratory chain complex I assembly (GO:0032981)2.97304026
68NADH dehydrogenase complex assembly (GO:0010257)2.97304026
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.97304026
70regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.96762939
71positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.96762939
72response to interferon-beta (GO:0035456)2.96474805
73regulation of cAMP-mediated signaling (GO:0043949)2.93449522
74regulation of B cell differentiation (GO:0045577)2.93019016
75intestinal epithelial cell development (GO:0060576)2.90657113
76mitochondrial respiratory chain complex assembly (GO:0033108)2.88782978
77negative regulation of signal transduction by p53 class mediator (GO:1901797)2.86800454
78negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85749999
79regulation of T-helper 1 type immune response (GO:0002825)2.82830693
80serotonin receptor signaling pathway (GO:0007210)2.78669486
81pyrimidine nucleoside catabolic process (GO:0046135)2.78323139
82regulation of B cell receptor signaling pathway (GO:0050855)2.78304313
83oligosaccharide catabolic process (GO:0009313)2.75806780
84deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.75759122
85positive regulation of protein homodimerization activity (GO:0090073)2.75069667
86response to pheromone (GO:0019236)2.72519777
87positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.72379191
88proteasome assembly (GO:0043248)2.68571785
89cellular response to interferon-beta (GO:0035458)2.65635929
90organelle membrane fusion (GO:0090174)2.65600422
91adenosine metabolic process (GO:0046085)2.65415250
92serotonin metabolic process (GO:0042428)2.63501889
93negative regulation of T cell apoptotic process (GO:0070233)2.61562109
94DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.60680207
95regulation of lymphocyte migration (GO:2000401)2.59375392
96regulation of sulfur metabolic process (GO:0042762)2.59227554
97rRNA catabolic process (GO:0016075)2.58974764
98regulation of cellular amino acid metabolic process (GO:0006521)2.56759901
99negative regulation of appetite (GO:0032099)2.55998290
100T cell migration (GO:0072678)10.6567175

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.51826599
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.35686898
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.41018409
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.36870973
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.09812486
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.97326823
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.88218053
8ZNF274_21170338_ChIP-Seq_K562_Hela2.80224436
9FUS_26573619_Chip-Seq_HEK293_Human2.73250202
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49051324
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.46375727
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.40795078
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34524226
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.25299669
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02924280
16ELK1_19687146_ChIP-ChIP_HELA_Human1.99685590
17GABP_17652178_ChIP-ChIP_JURKAT_Human1.95369851
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.93448856
19EWS_26573619_Chip-Seq_HEK293_Human1.91046412
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89523211
21HTT_18923047_ChIP-ChIP_STHdh_Human1.88578417
22P300_19829295_ChIP-Seq_ESCs_Human1.82219915
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80273485
24FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.78329154
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77376888
26IGF1R_20145208_ChIP-Seq_DFB_Human1.71593570
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69688554
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69224717
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.66449319
30TP53_22573176_ChIP-Seq_HFKS_Human1.54678706
31SMAD4_21799915_ChIP-Seq_A2780_Human1.53972734
32TAF15_26573619_Chip-Seq_HEK293_Human1.53801215
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49387651
34NANOG_19829295_ChIP-Seq_ESCs_Human1.49021452
35SOX2_19829295_ChIP-Seq_ESCs_Human1.49021452
36GBX2_23144817_ChIP-Seq_PC3_Human1.48172948
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47348064
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.43631311
39VDR_23849224_ChIP-Seq_CD4+_Human1.43457053
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43434162
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42674853
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40191617
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32585385
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25301043
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.25124290
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24217450
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.20507281
48BCAT_22108803_ChIP-Seq_LS180_Human1.19667031
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19317070
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.18701961
51ER_23166858_ChIP-Seq_MCF-7_Human1.17551334
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.17175808
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17175808
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16768030
55* GATA3_26560356_Chip-Seq_TH2_Human1.15792769
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15781472
57AR_20517297_ChIP-Seq_VCAP_Human1.15618258
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.15539825
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.15402597
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13550058
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13216185
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12427891
63FOXP3_21729870_ChIP-Seq_TREG_Human1.10511399
64VDR_22108803_ChIP-Seq_LS180_Human1.09871675
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.09174415
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08538921
67CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08370422
68RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07366264
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.07013701
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.06511565
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05599142
72* STAT3_23295773_ChIP-Seq_U87_Human1.05265564
73CDX2_22108803_ChIP-Seq_LS180_Human1.03319335
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03132508
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00709535
76STAT3_18555785_Chip-Seq_ESCs_Mouse0.99009150
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98838052
78OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97395930
79SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96662227
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96552473
81P53_22387025_ChIP-Seq_ESCs_Mouse0.96240268
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94716264
83EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93513988
84FOXH1_21741376_ChIP-Seq_EPCs_Human0.92739327
85FLI1_21867929_ChIP-Seq_TH2_Mouse0.92632385
86SMAD4_21741376_ChIP-Seq_EPCs_Human0.92365957
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92249869
88KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90761032
89GATA3_27048872_Chip-Seq_THYMUS_Human0.90758985
90RUNX2_22187159_ChIP-Seq_PCA_Human0.89837288
91* MYB_26560356_Chip-Seq_TH2_Human0.89604115
92SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.89553862
93P300_18555785_Chip-Seq_ESCs_Mouse0.88939682
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.88030917
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87608884
96OCT4_18555785_Chip-Seq_ESCs_Mouse0.87195531
97NFYA_21822215_ChIP-Seq_K562_Human0.87071718
98ERG_20517297_ChIP-Seq_VCAP_Human0.86661309
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.85980107
100YY1_21170310_ChIP-Seq_MESCs_Mouse0.85643660

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color7.78309558
2MP0003045_fibrosis3.95494348
3MP0005671_abnormal_response_to3.44000446
4MP0000372_irregular_coat_pigmentation3.24333117
5MP0004381_abnormal_hair_follicle3.12171737
6MP0002938_white_spotting3.07277572
7MP0004145_abnormal_muscle_electrophysio2.72718247
8MP0005379_endocrine/exocrine_gland_phen2.42249702
9MP0002876_abnormal_thyroid_physiology2.32266744
10MP0009785_altered_susceptibility_to2.32142388
11MP0005075_abnormal_melanosome_morpholog2.24275531
12MP0001542_abnormal_bone_strength2.22643448
13MP0006082_CNS_inflammation2.20498087
14MP0010386_abnormal_urinary_bladder2.14624145
15MP0005171_absent_coat_pigmentation2.08662202
16MP0002166_altered_tumor_susceptibility2.01648482
17MP0008877_abnormal_DNA_methylation1.99593569
18MP0005332_abnormal_amino_acid1.93900010
19MP0005645_abnormal_hypothalamus_physiol1.90391363
20MP0002168_other_aberrant_phenotype1.82994208
21MP0000516_abnormal_urinary_system1.82496791
22MP0005367_renal/urinary_system_phenotyp1.82496791
23MP0001346_abnormal_lacrimal_gland1.78132185
24MP0000537_abnormal_urethra_morphology1.76608418
25MP0002163_abnormal_gland_morphology1.76216897
26MP0003283_abnormal_digestive_organ1.71024609
27MP0000569_abnormal_digit_pigmentation1.55868499
28MP0003448_altered_tumor_morphology1.52898926
29MP0002095_abnormal_skin_pigmentation1.45057794
30MP0009697_abnormal_copulation1.41078428
31MP0005166_decreased_susceptibility_to1.39436544
32MP0003878_abnormal_ear_physiology1.36129057
33MP0005377_hearing/vestibular/ear_phenot1.36129057
34MP0002006_tumorigenesis1.32809020
35MP0004883_abnormal_blood_vessel1.32522075
36MP0000566_synostosis1.32491773
37MP0000383_abnormal_hair_follicle1.30169373
38MP0003937_abnormal_limbs/digits/tail_de1.30067423
39MP0006054_spinal_hemorrhage1.28361530
40MP0003950_abnormal_plasma_membrane1.26537125
41MP0006072_abnormal_retinal_apoptosis1.22431512
42MP0002148_abnormal_hypersensitivity_rea1.20895930
43MP0002638_abnormal_pupillary_reflex1.19724294
44MP0009333_abnormal_splenocyte_physiolog1.18777403
45MP0001835_abnormal_antigen_presentation1.14779763
46MP0000685_abnormal_immune_system1.14075661
47MP0003195_calcinosis1.14003717
48MP0003122_maternal_imprinting1.12047601
49MP0001186_pigmentation_phenotype1.09143035
50MP0001529_abnormal_vocalization1.07519015
51MP0003315_abnormal_perineum_morphology1.07074590
52MP0006276_abnormal_autonomic_nervous1.06035569
53MP0010094_abnormal_chromosome_stability1.04586463
54MP0001905_abnormal_dopamine_level1.02541496
55MP0003075_altered_response_to1.01810412
56MP0005187_abnormal_penis_morphology0.98758216
57MP0003385_abnormal_body_wall0.95027000
58MP0003252_abnormal_bile_duct0.93140916
59MP0000749_muscle_degeneration0.89818106
60MP0003137_abnormal_impulse_conducting0.88928204
61MP0009384_cardiac_valve_regurgitation0.87999794
62MP0010030_abnormal_orbit_morphology0.86860808
63MP0005025_abnormal_response_to0.86119678
64MP0005058_abnormal_lysosome_morphology0.85763936
65MP0005395_other_phenotype0.85440064
66MP0000538_abnormal_urinary_bladder0.85428728
67MP0008875_abnormal_xenobiotic_pharmacok0.85207035
68MP0001984_abnormal_olfaction0.81827301
69MP0005164_abnormal_response_to0.80613312
70MP0009745_abnormal_behavioral_response0.80522641
71MP0000427_abnormal_hair_cycle0.77695342
72MP0002653_abnormal_ependyma_morphology0.75979933
73MP0003690_abnormal_glial_cell0.75939193
74MP0002405_respiratory_system_inflammati0.75508737
75MP0000343_altered_response_to0.75502545
76MP0003866_abnormal_defecation0.74474793
77MP0010155_abnormal_intestine_physiology0.73942215
78MP0000613_abnormal_salivary_gland0.73641791
79MP0003786_premature_aging0.72461639
80MP0003763_abnormal_thymus_physiology0.72437740
81MP0005253_abnormal_eye_physiology0.68072529
82MP0002075_abnormal_coat/hair_pigmentati0.67261935
83MP0001324_abnormal_eye_pigmentation0.65555715
84MP0008469_abnormal_protein_level0.65178594
85MP0009250_abnormal_appendicular_skeleto0.63064898
86MP0009643_abnormal_urine_homeostasis0.62761216
87MP0002693_abnormal_pancreas_physiology0.62643030
88MP0001502_abnormal_circadian_rhythm0.62398355
89MP0001944_abnormal_pancreas_morphology0.60691444
90MP0002736_abnormal_nociception_after0.60381091
91MP0005310_abnormal_salivary_gland0.59039916
92MP0003938_abnormal_ear_development0.58180326
93MP0002751_abnormal_autonomic_nervous0.57418822
94MP0005636_abnormal_mineral_homeostasis0.57127233
95MP0000639_abnormal_adrenal_gland0.56539365
96MP0009046_muscle_twitch0.56022817
97MP0003632_abnormal_nervous_system0.55275917
98MP0005551_abnormal_eye_electrophysiolog0.54869268
99MP0000631_abnormal_neuroendocrine_gland0.54111083
100MP0003121_genomic_imprinting0.54071554

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)7.14552136
2Hypoproteinemia (HP:0003075)4.85935792
3Septate vagina (HP:0001153)4.66591628
4Aplastic anemia (HP:0001915)4.13035799
5Renal Fanconi syndrome (HP:0001994)3.87044349
6T lymphocytopenia (HP:0005403)3.86839157
7Spontaneous abortion (HP:0005268)3.83270111
8Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.79337683
9Short 1st metacarpal (HP:0010034)3.79337683
10Abnormality of T cell number (HP:0011839)3.75767270
11Thyroiditis (HP:0100646)3.74312996
12Hypoplasia of the thymus (HP:0000778)3.72577408
13Severe combined immunodeficiency (HP:0004430)3.63960516
14Abnormality of the 1st metacarpal (HP:0010009)3.35767322
15Increased hepatocellular lipid droplets (HP:0006565)3.22300159
16Short hallux (HP:0010109)3.14217648
17Generalized aminoaciduria (HP:0002909)3.10694272
18Large eyes (HP:0001090)3.06434575
19Popliteal pterygium (HP:0009756)3.04040739
20Combined immunodeficiency (HP:0005387)3.02850278
21Septo-optic dysplasia (HP:0100842)2.98441831
22Intestinal atresia (HP:0011100)2.97854665
23Abnormality of the 2nd finger (HP:0004100)2.96584685
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.95683997
25Stomatitis (HP:0010280)2.95309433
26Hypothermia (HP:0002045)2.88570560
27Abnormality of eosinophils (HP:0001879)2.85209426
28Gastrointestinal atresia (HP:0002589)2.80422556
29Abnormal tarsal ossification (HP:0008369)2.77124779
30Aplasia/Hypoplasia of the hallux (HP:0008362)2.76622308
31Reduced antithrombin III activity (HP:0001976)2.75898286
32Lipid accumulation in hepatocytes (HP:0006561)2.62725508
33Ureteral obstruction (HP:0006000)2.59978926
34Absent septum pellucidum (HP:0001331)2.59172098
35Bile duct proliferation (HP:0001408)2.57992510
36Abnormal biliary tract physiology (HP:0012439)2.57992510
37Optic nerve hypoplasia (HP:0000609)2.55344439
38Exertional dyspnea (HP:0002875)2.55149433
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.52437709
40Esophageal atresia (HP:0002032)2.52085342
41Eosinophilia (HP:0001880)2.48440705
42Abnormality of the septum pellucidum (HP:0007375)2.46711130
43Abnormal foot bone ossification (HP:0010675)2.42205311
44Fatigue (HP:0012378)2.41080824
45Abnormality of renal resorption (HP:0011038)2.40436412
46Hemiplegia (HP:0002301)2.37800747
47Chronic diarrhea (HP:0002028)2.36754695
48Pancreatic cysts (HP:0001737)2.36052711
49Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.29544256
50Anteriorly placed anus (HP:0001545)2.26093861
51Short phalanx of the thumb (HP:0009660)2.24774435
52IgG deficiency (HP:0004315)2.22865634
53Type I transferrin isoform profile (HP:0003642)2.21805469
54Vacuolated lymphocytes (HP:0001922)2.16534502
55Amniotic constriction ring (HP:0009775)2.15589949
56Abnormality of placental membranes (HP:0011409)2.15589949
57Hypoalbuminemia (HP:0003073)2.14656505
58Abnormal albumin level (HP:0012116)2.14656505
59Ureteral stenosis (HP:0000071)2.11329673
60Panhypogammaglobulinemia (HP:0003139)2.11240525
61Overfolded helix (HP:0000396)2.11016066
62Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.09771257
63Glycosuria (HP:0003076)2.06321656
64Abnormality of urine glucose concentration (HP:0011016)2.06321656
65Renal cortical cysts (HP:0000803)2.04471406
66Urethral obstruction (HP:0000796)2.02574077
67Abnormality of macrophages (HP:0004311)2.00959571
68Delayed CNS myelination (HP:0002188)1.98393322
69Aplasia/Hypoplasia involving the musculature (HP:0001460)1.98278281
70Abnormality of T cells (HP:0002843)1.97952969
71Leukocytosis (HP:0001974)1.96604061
72Spondylolisthesis (HP:0003302)1.96394626
73Increased CSF protein (HP:0002922)1.95787177
74Mitochondrial inheritance (HP:0001427)1.93993723
75Constricted visual fields (HP:0001133)1.93580247
76Beaking of vertebral bodies (HP:0004568)1.92742827
77Abnormality of the musculature of the hand (HP:0001421)1.90725043
78Failure to thrive in infancy (HP:0001531)1.90177773
79Anal stenosis (HP:0002025)1.88663150
80Recurrent bronchitis (HP:0002837)1.87464974
81Abnormality of the costochondral junction (HP:0000919)1.86839494
82B lymphocytopenia (HP:0010976)1.86249268
83Stomach cancer (HP:0012126)1.84631343
84Absent/shortened dynein arms (HP:0200106)1.83869099
85Dynein arm defect of respiratory motile cilia (HP:0012255)1.83869099
86Increased intramyocellular lipid droplets (HP:0012240)1.82595945
87Recurrent cutaneous fungal infections (HP:0011370)1.82268763
88Chronic mucocutaneous candidiasis (HP:0002728)1.82268763
89Palpebral edema (HP:0100540)1.79054238
90Hepatocellular necrosis (HP:0001404)1.77651556
91Recurrent corneal erosions (HP:0000495)1.77564739
92Increased CSF lactate (HP:0002490)1.76738171
93Delayed gross motor development (HP:0002194)1.75996021
94Molar tooth sign on MRI (HP:0002419)1.75447727
95Abnormality of midbrain morphology (HP:0002418)1.75447727
96Abnormality of the renal cortex (HP:0011035)1.75046255
97Abnormal glycosylation (HP:0012345)1.73698524
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73698524
99Abnormal protein N-linked glycosylation (HP:0012347)1.73698524
100Abnormal protein glycosylation (HP:0012346)1.73698524

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.95351478
2BCKDK3.89170692
3TRIM283.65322848
4MAP3K123.43097716
5SRPK13.11924590
6CCNB12.55841261
7EIF2AK32.17294032
8FRK2.15111801
9GRK12.08361603
10PAK32.04173859
11TNIK2.03243588
12STK38L1.98761256
13STK161.98625858
14WNK31.94779126
15MST1R1.93262582
16STK391.84454566
17MUSK1.84235447
18MKNK21.77939011
19NUAK11.75044508
20FGFR21.71928518
21BCR1.63925100
22TAOK31.63327491
23EIF2AK11.61301043
24MAPK131.51241768
25TYK21.45987030
26PRKCQ1.36123006
27OXSR11.21403423
28STK241.16728620
29STK31.14235932
30TEC1.12974372
31NTRK31.11522195
32ITK1.11136846
33BRSK21.09339167
34ZAK1.09038671
35SYK0.95014304
36PINK10.90565179
37VRK10.88617995
38LATS10.86961873
39ADRBK20.83380442
40MKNK10.82813455
41NME20.81488670
42ATR0.80361967
43WNK40.78169017
44KDR0.76231682
45PLK10.73218641
46OBSCN0.71887673
47INSR0.70980741
48TRPM70.70559494
49INSRR0.67766407
50DAPK10.62006433
51MYLK0.61341214
52NLK0.60267671
53PLK30.58341008
54STK40.58250055
55FGFR30.57967101
56PRKCE0.55758181
57MINK10.52223107
58TGFBR10.51047523
59PRKCH0.50821896
60YES10.50183372
61PKN10.48075392
62IKBKB0.47692673
63STK100.47114832
64GRK60.44546442
65MAP2K70.44112387
66CAMK2D0.43808909
67CSK0.43769892
68JAK20.43123136
69DAPK20.42915794
70LCK0.42752636
71PRKD20.42726944
72PTK2B0.42589758
73ADRBK10.41393964
74ACVR1B0.40992588
75EGFR0.40418623
76CSNK2A10.39978301
77MST40.39055605
78TIE10.38661212
79CSNK2A20.37423109
80CSNK1A10.34135483
81TXK0.32877047
82MAPK110.32445920
83EIF2AK20.32243450
84ROCK10.31893517
85MAP4K10.31302291
86CSF1R0.31072493
87IRAK40.30742354
88CAMK2B0.30314178
89FYN0.29625277
90VRK20.29532060
91MAP2K40.28507381
92PRKACA0.27523410
93ROCK20.27189386
94LYN0.26612009
95PRKG10.25968325
96IGF1R0.25450096
97BTK0.25364129
98PRKCA0.25109165
99AURKB0.24995870
100MAP3K50.24480291

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.49425189
2Primary immunodeficiency_Homo sapiens_hsa053404.30553295
3Protein export_Homo sapiens_hsa030603.44838057
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.41192580
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.39022508
6Sulfur metabolism_Homo sapiens_hsa009202.92946755
7Autoimmune thyroid disease_Homo sapiens_hsa053202.63220050
8Propanoate metabolism_Homo sapiens_hsa006402.53261059
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.43405935
10Steroid biosynthesis_Homo sapiens_hsa001002.33928878
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.30919565
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.29783580
13Homologous recombination_Homo sapiens_hsa034402.23120912
14Basal transcription factors_Homo sapiens_hsa030222.19614008
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.15310502
16Allograft rejection_Homo sapiens_hsa053302.14470114
17Type I diabetes mellitus_Homo sapiens_hsa049402.02767022
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.01425282
19Graft-versus-host disease_Homo sapiens_hsa053321.96621686
20Butanoate metabolism_Homo sapiens_hsa006501.81300562
21Phototransduction_Homo sapiens_hsa047441.73297322
22Oxidative phosphorylation_Homo sapiens_hsa001901.69065653
23Selenocompound metabolism_Homo sapiens_hsa004501.53419025
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50119342
25Fanconi anemia pathway_Homo sapiens_hsa034601.40456198
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.40227696
27Parkinsons disease_Homo sapiens_hsa050121.37171945
28Antigen processing and presentation_Homo sapiens_hsa046121.26949313
29Fatty acid elongation_Homo sapiens_hsa000621.16817569
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15709972
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07146557
32RNA polymerase_Homo sapiens_hsa030201.03634255
33Ether lipid metabolism_Homo sapiens_hsa005651.02429484
34Peroxisome_Homo sapiens_hsa041461.01452331
35Other glycan degradation_Homo sapiens_hsa005110.97888140
36T cell receptor signaling pathway_Homo sapiens_hsa046600.95716393
37Huntingtons disease_Homo sapiens_hsa050160.92550562
38Non-homologous end-joining_Homo sapiens_hsa034500.91463684
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91346040
40Asthma_Homo sapiens_hsa053100.91147789
41Measles_Homo sapiens_hsa051620.90899672
42Nucleotide excision repair_Homo sapiens_hsa034200.88447147
43Mineral absorption_Homo sapiens_hsa049780.87757918
44Hematopoietic cell lineage_Homo sapiens_hsa046400.81663843
45Dorso-ventral axis formation_Homo sapiens_hsa043200.80399314
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.78807454
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78144914
48Herpes simplex infection_Homo sapiens_hsa051680.77737388
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76352134
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75610366
51Regulation of autophagy_Homo sapiens_hsa041400.72921241
52Nitrogen metabolism_Homo sapiens_hsa009100.69487036
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65940462
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61633292
55Ribosome_Homo sapiens_hsa030100.61073632
56Purine metabolism_Homo sapiens_hsa002300.56688929
57Cardiac muscle contraction_Homo sapiens_hsa042600.56029157
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.55017998
59Shigellosis_Homo sapiens_hsa051310.54980300
60Pyrimidine metabolism_Homo sapiens_hsa002400.51889354
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51235642
62RNA degradation_Homo sapiens_hsa030180.50819280
63Alzheimers disease_Homo sapiens_hsa050100.47336716
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46401673
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46258052
66beta-Alanine metabolism_Homo sapiens_hsa004100.44834463
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44666889
68Mismatch repair_Homo sapiens_hsa034300.40544927
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40504049
70Viral myocarditis_Homo sapiens_hsa054160.40191316
71* Taste transduction_Homo sapiens_hsa047420.39600433
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39511095
73Fatty acid metabolism_Homo sapiens_hsa012120.38672642
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38003665
75Influenza A_Homo sapiens_hsa051640.36803459
76Oocyte meiosis_Homo sapiens_hsa041140.35865130
77p53 signaling pathway_Homo sapiens_hsa041150.34745213
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33336755
79RNA transport_Homo sapiens_hsa030130.31575589
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.30865057
81Arginine biosynthesis_Homo sapiens_hsa002200.28498808
82Rheumatoid arthritis_Homo sapiens_hsa053230.27490345
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26441519
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.25878888
85Caffeine metabolism_Homo sapiens_hsa002320.25812418
86Linoleic acid metabolism_Homo sapiens_hsa005910.25078386
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23868811
88Leishmaniasis_Homo sapiens_hsa051400.23755187
89Metabolic pathways_Homo sapiens_hsa011000.22635039
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.21033514
91mRNA surveillance pathway_Homo sapiens_hsa030150.20944407
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.20338321
93Circadian rhythm_Homo sapiens_hsa047100.18409209
94Olfactory transduction_Homo sapiens_hsa047400.18038086
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16503125
96Collecting duct acid secretion_Homo sapiens_hsa049660.14678417
97Lysosome_Homo sapiens_hsa041420.14661970
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14417500
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13983383
100TGF-beta signaling pathway_Homo sapiens_hsa043500.12991112

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