TAS2R4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.50058932
2L-fucose catabolic process (GO:0042355)4.76677129
3fucose catabolic process (GO:0019317)4.76677129
4L-fucose metabolic process (GO:0042354)4.76677129
5presynaptic membrane assembly (GO:0097105)3.59115693
6pyrimidine nucleobase catabolic process (GO:0006208)3.57470805
7kynurenine metabolic process (GO:0070189)3.57381448
8nonmotile primary cilium assembly (GO:0035058)3.56700209
9indole-containing compound catabolic process (GO:0042436)3.46534898
10indolalkylamine catabolic process (GO:0046218)3.46534898
11tryptophan catabolic process (GO:0006569)3.46534898
12water-soluble vitamin biosynthetic process (GO:0042364)3.41902289
13replication fork processing (GO:0031297)3.36847281
14detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.33637366
15limb bud formation (GO:0060174)3.33292792
16neural tube formation (GO:0001841)3.32884966
17transmission of nerve impulse (GO:0019226)3.30141563
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.27169732
19NADH dehydrogenase complex assembly (GO:0010257)3.27169732
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.27169732
21cellular ketone body metabolic process (GO:0046950)3.26120533
22behavioral response to ethanol (GO:0048149)3.23454700
23protein complex biogenesis (GO:0070271)3.21660620
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.20406057
25protein polyglutamylation (GO:0018095)3.17355494
26platelet dense granule organization (GO:0060155)3.13999836
27indolalkylamine metabolic process (GO:0006586)3.13085670
28regulation of cilium movement (GO:0003352)3.12837986
29negative regulation of translation, ncRNA-mediated (GO:0040033)3.12205446
30regulation of translation, ncRNA-mediated (GO:0045974)3.12205446
31negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.12205446
32mitochondrial respiratory chain complex assembly (GO:0033108)3.12198421
33ubiquinone biosynthetic process (GO:0006744)3.11994739
34response to pheromone (GO:0019236)3.09750529
35epithelial cilium movement (GO:0003351)3.09428148
36presynaptic membrane organization (GO:0097090)3.05788312
37cilium morphogenesis (GO:0060271)3.05057991
38respiratory chain complex IV assembly (GO:0008535)3.04684748
39nucleobase catabolic process (GO:0046113)3.04284185
40postsynaptic membrane organization (GO:0001941)3.04066334
41ubiquinone metabolic process (GO:0006743)3.01839118
42gamma-aminobutyric acid transport (GO:0015812)2.97284721
43cerebral cortex radially oriented cell migration (GO:0021799)2.96627026
44axoneme assembly (GO:0035082)2.96198409
45negative regulation of telomere maintenance (GO:0032205)2.95215810
46somite development (GO:0061053)2.93523883
47regulation of nuclear cell cycle DNA replication (GO:0033262)2.90128331
48establishment of protein localization to mitochondrial membrane (GO:0090151)2.90052872
49negative regulation of synaptic transmission, GABAergic (GO:0032229)2.87575114
50DNA deamination (GO:0045006)2.87349705
51G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86955674
52tryptophan metabolic process (GO:0006568)2.86886443
53ketone body metabolic process (GO:1902224)2.86490262
54cytochrome complex assembly (GO:0017004)2.82332442
55synapsis (GO:0007129)2.74290807
56cilium organization (GO:0044782)2.70445445
57neuronal action potential (GO:0019228)2.70269892
58protein-cofactor linkage (GO:0018065)2.69050413
59kidney morphogenesis (GO:0060993)2.68753986
60protein localization to cilium (GO:0061512)2.67973956
61retinal cone cell development (GO:0046549)2.66747727
62cilium assembly (GO:0042384)2.66738544
63sulfation (GO:0051923)2.64778154
64photoreceptor cell maintenance (GO:0045494)2.64564546
65nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.63958742
66reflex (GO:0060004)2.63149037
67primary amino compound metabolic process (GO:1901160)2.62939471
68RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.61571138
69negative regulation of DNA-dependent DNA replication (GO:2000104)2.61006227
70regulation of glucokinase activity (GO:0033131)2.60701987
71regulation of hexokinase activity (GO:1903299)2.60701987
72piRNA metabolic process (GO:0034587)2.59387824
73exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.58535043
74indole-containing compound metabolic process (GO:0042430)2.58432370
75neuron cell-cell adhesion (GO:0007158)2.58028464
76negative regulation of cytosolic calcium ion concentration (GO:0051481)2.56887787
77photoreceptor cell development (GO:0042461)2.55841410
78preassembly of GPI anchor in ER membrane (GO:0016254)2.55236602
79detection of light stimulus involved in visual perception (GO:0050908)2.53680495
80detection of light stimulus involved in sensory perception (GO:0050962)2.53680495
81synaptic transmission, cholinergic (GO:0007271)2.53654278
82regulation of action potential (GO:0098900)2.52317503
83negative regulation of transcription regulatory region DNA binding (GO:2000678)2.51234006
84recombinational repair (GO:0000725)2.51076472
85DNA double-strand break processing (GO:0000729)2.50940205
86negative regulation of astrocyte differentiation (GO:0048712)2.50817453
87startle response (GO:0001964)2.50113306
88intraciliary transport (GO:0042073)2.50023476
89double-strand break repair via homologous recombination (GO:0000724)2.49698233
90inner ear receptor stereocilium organization (GO:0060122)2.46741784
91reciprocal meiotic recombination (GO:0007131)2.46489842
92reciprocal DNA recombination (GO:0035825)2.46489842
93quinone biosynthetic process (GO:1901663)2.45368529
94head development (GO:0060322)2.44190681
95cilium movement (GO:0003341)2.43372652
96cellular biogenic amine catabolic process (GO:0042402)2.42393748
97amine catabolic process (GO:0009310)2.42393748
98hindbrain development (GO:0030902)2.42085589
99regulation of telomere maintenance (GO:0032204)2.42017214
100cornea development in camera-type eye (GO:0061303)2.41753992

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.08768420
2GBX2_23144817_ChIP-Seq_PC3_Human3.31614523
3EZH2_22144423_ChIP-Seq_EOC_Human3.28763307
4VDR_22108803_ChIP-Seq_LS180_Human3.05442014
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.77908435
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.65250816
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58558633
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54839998
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.38956387
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.34443691
11EWS_26573619_Chip-Seq_HEK293_Human2.30843968
12IGF1R_20145208_ChIP-Seq_DFB_Human2.27028866
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.25626590
14FUS_26573619_Chip-Seq_HEK293_Human2.25343095
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.21142808
16TAF15_26573619_Chip-Seq_HEK293_Human2.09477453
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04554114
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03322052
19P300_19829295_ChIP-Seq_ESCs_Human2.02631594
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.93855519
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86017655
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81465552
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75538621
24ER_23166858_ChIP-Seq_MCF-7_Human1.73789891
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68552317
26MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.66708440
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64235977
28IRF1_19129219_ChIP-ChIP_H3396_Human1.63322669
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.62813159
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.60732916
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59140852
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56860611
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56333687
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.54514681
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.54242017
36BCAT_22108803_ChIP-Seq_LS180_Human1.53824758
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53824478
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52846274
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50864619
40STAT3_23295773_ChIP-Seq_U87_Human1.49046486
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48987525
42SMAD4_21799915_ChIP-Seq_A2780_Human1.47064294
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46782500
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.45727055
45AR_25329375_ChIP-Seq_VCAP_Human1.45059238
46CBP_20019798_ChIP-Seq_JUKART_Human1.44703996
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44703996
48REST_21632747_ChIP-Seq_MESCs_Mouse1.43942015
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43672283
50TP53_22573176_ChIP-Seq_HFKS_Human1.43610728
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41545226
52* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39849583
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38414433
54TCF4_23295773_ChIP-Seq_U87_Human1.37952959
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37645576
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37645576
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.37379749
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36070929
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.33198205
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32131259
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.31176523
62MYC_18940864_ChIP-ChIP_HL60_Human1.31035990
63TCF4_22108803_ChIP-Seq_LS180_Human1.30334315
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29887683
65NANOG_19829295_ChIP-Seq_ESCs_Human1.29798693
66SOX2_19829295_ChIP-Seq_ESCs_Human1.29798693
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25464406
68ELK1_19687146_ChIP-ChIP_HELA_Human1.25297771
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24252233
70RUNX2_22187159_ChIP-Seq_PCA_Human1.19538769
71RNF2_27304074_Chip-Seq_NSC_Mouse1.18988136
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18919492
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15425982
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15290810
75AR_21572438_ChIP-Seq_LNCaP_Human1.14643575
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.14534795
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13568579
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13559343
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13303383
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11687102
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.11448284
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11448284
83P53_22387025_ChIP-Seq_ESCs_Mouse1.10914699
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09912568
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.07245193
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.06999069
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.06866334
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06333276
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06093710
90* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06016371
91GATA3_21878914_ChIP-Seq_MCF-7_Human1.05277842
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04210892
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.04148553
94NCOR_22424771_ChIP-Seq_293T_Human1.02371927
95TP63_19390658_ChIP-ChIP_HaCaT_Human1.01377201
96AR_20517297_ChIP-Seq_VCAP_Human0.99682465
97TP53_16413492_ChIP-PET_HCT116_Human0.99187656
98STAT3_18555785_Chip-Seq_ESCs_Mouse0.97167715
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96714400
100HOXB7_26014856_ChIP-Seq_BT474_Human0.93730570

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern2.78976814
2MP0008877_abnormal_DNA_methylation2.61561580
3MP0001968_abnormal_touch/_nociception2.44801752
4MP0002102_abnormal_ear_morphology2.42046019
5MP0006292_abnormal_olfactory_placode2.36600391
6MP0005551_abnormal_eye_electrophysiolog2.31774483
7MP0004885_abnormal_endolymph2.30538585
8MP0003136_yellow_coat_color2.28216519
9MP0003195_calcinosis2.27765976
10MP0002736_abnormal_nociception_after2.12330040
11MP0009046_muscle_twitch2.00828293
12MP0000569_abnormal_digit_pigmentation2.00245433
13MP0001529_abnormal_vocalization1.95616253
14MP0002653_abnormal_ependyma_morphology1.94505269
15MP0009745_abnormal_behavioral_response1.92785564
16MP0006072_abnormal_retinal_apoptosis1.92258670
17MP0001984_abnormal_olfaction1.90809486
18MP0002638_abnormal_pupillary_reflex1.89390730
19MP0004142_abnormal_muscle_tone1.87954524
20MP0000631_abnormal_neuroendocrine_gland1.73799788
21MP0004133_heterotaxia1.68241729
22MP0001486_abnormal_startle_reflex1.67636959
23MP0002876_abnormal_thyroid_physiology1.66773994
24MP0000427_abnormal_hair_cycle1.66015253
25MP0004742_abnormal_vestibular_system1.65007514
26MP0002272_abnormal_nervous_system1.64859576
27MP0005253_abnormal_eye_physiology1.63903424
28MP0002938_white_spotting1.63618142
29MP0001485_abnormal_pinna_reflex1.62624706
30MP0006276_abnormal_autonomic_nervous1.61017538
31MP0002837_dystrophic_cardiac_calcinosis1.57952453
32MP0000647_abnormal_sebaceous_gland1.57706093
33MP0000778_abnormal_nervous_system1.57693745
34MP0003787_abnormal_imprinting1.57204842
35MP0008875_abnormal_xenobiotic_pharmacok1.54953340
36MP0005646_abnormal_pituitary_gland1.52007709
37MP0001986_abnormal_taste_sensitivity1.50362411
38MP0002234_abnormal_pharynx_morphology1.44072728
39MP0008789_abnormal_olfactory_epithelium1.43279917
40MP0008872_abnormal_physiological_respon1.42241577
41MP0002064_seizures1.41996256
42MP0005084_abnormal_gallbladder_morpholo1.40689620
43MP0003646_muscle_fatigue1.40265545
44MP0004147_increased_porphyrin_level1.38309330
45MP0004043_abnormal_pH_regulation1.37780088
46MP0002572_abnormal_emotion/affect_behav1.37484981
47MP0000372_irregular_coat_pigmentation1.32371374
48MP0002733_abnormal_thermal_nociception1.32228118
49MP0001501_abnormal_sleep_pattern1.31012580
50MP0002067_abnormal_sensory_capabilities1.30779231
51MP0003635_abnormal_synaptic_transmissio1.29535739
52MP0001293_anophthalmia1.29318605
53MP0002557_abnormal_social/conspecific_i1.26012284
54MP0002751_abnormal_autonomic_nervous1.25508898
55MP0005645_abnormal_hypothalamus_physiol1.25492304
56MP0002063_abnormal_learning/memory/cond1.24676200
57MP0001970_abnormal_pain_threshold1.23068163
58MP0002735_abnormal_chemical_nociception1.20293478
59MP0005174_abnormal_tail_pigmentation1.18746549
60MP0002734_abnormal_mechanical_nocicepti1.15446525
61MP0003567_abnormal_fetal_cardiomyocyte1.14497756
62MP0002095_abnormal_skin_pigmentation1.13651252
63MP0000383_abnormal_hair_follicle1.12997211
64MP0000566_synostosis1.12426022
65MP0000026_abnormal_inner_ear1.12386916
66MP0005386_behavior/neurological_phenoty1.12206030
67MP0004924_abnormal_behavior1.12206030
68MP0005195_abnormal_posterior_eye1.12205483
69MP0002160_abnormal_reproductive_system1.09363814
70MP0001919_abnormal_reproductive_system1.08541968
71MP0002752_abnormal_somatic_nervous1.08531959
72MP0000049_abnormal_middle_ear1.08394332
73MP0008058_abnormal_DNA_repair1.07412149
74MP0005389_reproductive_system_phenotype1.06883982
75MP0003122_maternal_imprinting1.04018294
76MP0003011_delayed_dark_adaptation1.03750498
77MP0003718_maternal_effect1.03246920
78MP0010030_abnormal_orbit_morphology1.03007455
79MP0004145_abnormal_muscle_electrophysio1.02678617
80MP0001764_abnormal_homeostasis1.02423940
81MP0005499_abnormal_olfactory_system1.01353947
82MP0005394_taste/olfaction_phenotype1.01353947
83MP0002233_abnormal_nose_morphology0.99773646
84MP0003937_abnormal_limbs/digits/tail_de0.98724285
85MP0002928_abnormal_bile_duct0.98647659
86MP0003938_abnormal_ear_development0.98605112
87MP0003121_genomic_imprinting0.98554944
88MP0003698_abnormal_male_reproductive0.97814301
89MP0002282_abnormal_trachea_morphology0.96414664
90MP0005187_abnormal_penis_morphology0.95690351
91MP0002184_abnormal_innervation0.93585472
92MP0002882_abnormal_neuron_morphology0.89501529
93MP0003119_abnormal_digestive_system0.88839706
94MP0001286_abnormal_eye_development0.88828554
95MP0001963_abnormal_hearing_physiology0.88663723
96MP0001929_abnormal_gametogenesis0.84841760
97MP0005391_vision/eye_phenotype0.84623768
98MP0003137_abnormal_impulse_conducting0.82827253
99MP0002210_abnormal_sex_determination0.82628157
100MP0001324_abnormal_eye_pigmentation0.82473838

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.42237981
2Molar tooth sign on MRI (HP:0002419)4.40356936
3Abnormality of midbrain morphology (HP:0002418)4.40356936
4Pancreatic fibrosis (HP:0100732)4.27608513
5True hermaphroditism (HP:0010459)4.05959424
6Nephronophthisis (HP:0000090)3.77205212
7Congenital stationary night blindness (HP:0007642)3.51199886
8Type II lissencephaly (HP:0007260)3.38282453
9Abnormality of the renal medulla (HP:0100957)3.27409638
10Hyperventilation (HP:0002883)3.13089686
11Medial flaring of the eyebrow (HP:0010747)3.11356411
12Abnormality of the renal cortex (HP:0011035)2.97975812
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.87915869
14Abnormality of alanine metabolism (HP:0010916)2.87915869
15Hyperalaninemia (HP:0003348)2.87915869
16Cystic liver disease (HP:0006706)2.81853308
17Chronic hepatic failure (HP:0100626)2.80542364
18Lissencephaly (HP:0001339)2.79418928
19Pendular nystagmus (HP:0012043)2.76612885
20Gait imbalance (HP:0002141)2.73674491
21Abnormality of the labia minora (HP:0012880)2.68370796
22Abnormal biliary tract physiology (HP:0012439)2.65901444
23Bile duct proliferation (HP:0001408)2.65901444
24Congenital primary aphakia (HP:0007707)2.62815590
25Sclerocornea (HP:0000647)2.54496289
26Inability to walk (HP:0002540)2.53361470
27Broad-based gait (HP:0002136)2.52322985
28Attenuation of retinal blood vessels (HP:0007843)2.49844316
29Aplasia/Hypoplasia of the tongue (HP:0010295)2.45223909
30Nephrogenic diabetes insipidus (HP:0009806)2.44124327
31Furrowed tongue (HP:0000221)2.42285797
32Cerebellar dysplasia (HP:0007033)2.37822294
33Genital tract atresia (HP:0001827)2.37296503
34Tubular atrophy (HP:0000092)2.36133738
35Anencephaly (HP:0002323)2.35634405
36Abolished electroretinogram (ERG) (HP:0000550)2.33766638
37Vaginal atresia (HP:0000148)2.33647857
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.32752820
39Renal cortical cysts (HP:0000803)2.24954203
40Progressive inability to walk (HP:0002505)2.22735938
41Increased corneal curvature (HP:0100692)2.22275937
42Keratoconus (HP:0000563)2.22275937
43Pachygyria (HP:0001302)2.17681879
44Hyperglycinemia (HP:0002154)2.14739731
45Acute necrotizing encephalopathy (HP:0006965)2.10896645
46Concave nail (HP:0001598)2.09967112
47Anophthalmia (HP:0000528)2.08820568
48Postaxial foot polydactyly (HP:0001830)2.08118927
49Large for gestational age (HP:0001520)2.07554353
50Hemiparesis (HP:0001269)2.05981324
51Congenital hepatic fibrosis (HP:0002612)2.05929977
52Abnormal rod and cone electroretinograms (HP:0008323)2.05247992
53Stomach cancer (HP:0012126)2.00273500
54Chorioretinal atrophy (HP:0000533)2.00178549
55Male pseudohermaphroditism (HP:0000037)1.99705751
56Colon cancer (HP:0003003)1.99547612
57Optic nerve hypoplasia (HP:0000609)1.99471171
58Decreased central vision (HP:0007663)1.99185625
59Ectopic kidney (HP:0000086)1.98872925
60Retinal dysplasia (HP:0007973)1.97071891
61Febrile seizures (HP:0002373)1.96520075
62Abnormality of the ileum (HP:0001549)1.96386720
63Gaze-evoked nystagmus (HP:0000640)1.96386398
64Absent speech (HP:0001344)1.95387977
65Progressive macrocephaly (HP:0004481)1.95002449
66Acute encephalopathy (HP:0006846)1.94838864
67Meckel diverticulum (HP:0002245)1.94286885
68Poor coordination (HP:0002370)1.94093047
69Hyperglycinuria (HP:0003108)1.92418642
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91834829
71Abnormal drinking behavior (HP:0030082)1.91788496
72Polydipsia (HP:0001959)1.91788496
73Postaxial hand polydactyly (HP:0001162)1.89477619
74Birth length less than 3rd percentile (HP:0003561)1.88686826
75Hypoplasia of the pons (HP:0012110)1.87923166
76Abnormality of the pons (HP:0007361)1.87583206
77Astigmatism (HP:0000483)1.85977922
78Optic disc pallor (HP:0000543)1.85444145
79Protruding tongue (HP:0010808)1.84863570
80Progressive cerebellar ataxia (HP:0002073)1.84500380
81Abnormal number of erythroid precursors (HP:0012131)1.84440019
82Mitochondrial inheritance (HP:0001427)1.84296088
83Congenital, generalized hypertrichosis (HP:0004540)1.83187068
84Absent thumb (HP:0009777)1.80303130
85Increased CSF lactate (HP:0002490)1.80082052
86Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.78503967
87Polyuria (HP:0000103)1.78465786
88Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77009331
89Preaxial hand polydactyly (HP:0001177)1.76487661
903-Methylglutaconic aciduria (HP:0003535)1.76173687
91Dandy-Walker malformation (HP:0001305)1.76164949
92Patellar aplasia (HP:0006443)1.75617009
93Duplicated collecting system (HP:0000081)1.75310259
94Oligodactyly (hands) (HP:0001180)1.74583570
95Narrow forehead (HP:0000341)1.74463716
96Bilateral microphthalmos (HP:0007633)1.73330470
97Abnormality of the renal collecting system (HP:0004742)1.72889323
98Tachypnea (HP:0002789)1.72653932
99Sloping forehead (HP:0000340)1.72263010
100Focal motor seizures (HP:0011153)1.71715167

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.53257519
2ADRBK23.30636804
3MAP4K22.93852719
4TNIK2.83730294
5WNK32.70499006
6BMPR1B2.53911175
7CASK2.50811845
8PINK12.40975561
9ZAK2.30581402
10MAPK132.27053726
11INSRR2.25793663
12NUAK12.24387834
13GRK12.21614905
14MARK12.05308971
15PNCK1.96368332
16ACVR1B1.93718252
17MAP3K41.85280691
18TLK11.65288211
19WNK41.63156131
20TAOK31.60948756
21DYRK21.56784085
22CAMKK21.51128758
23EPHA41.49591538
24NTRK31.32857369
25BCR1.31546965
26MAP2K71.28539786
27VRK11.27130546
28BRSK21.23551538
29OXSR11.21992283
30TGFBR11.17720798
31STK161.14536878
32WEE11.12035429
33MKNK21.11671024
34NTRK21.10849681
35FGFR21.07545700
36STK391.07147987
37PAK31.03449556
38ADRBK10.97446871
39PRKCG0.97040365
40PIK3CA0.97006800
41DAPK20.95942224
42PLK30.93113493
43TRIM280.90349334
44PRKCE0.87793360
45PLK40.87590919
46PLK20.85551344
47CSNK1G10.81655927
48IRAK10.76992262
49EPHA30.74356099
50CSNK1G20.70711410
51NLK0.65535178
52MKNK10.62925113
53PRKD30.61006316
54CSNK1G30.60905366
55MAPK150.59332461
56PKN10.58608973
57EIF2AK30.56864345
58DYRK30.56708147
59EPHB20.56623553
60RPS6KA50.56176391
61BCKDK0.54416671
62SIK20.54158422
63TIE10.54060276
64CAMK2A0.53578441
65CSNK1A1L0.53526807
66CAMK1D0.49076870
67CSNK1A10.48749790
68CDC70.48309809
69STK110.48153100
70PHKG10.47739765
71PHKG20.47739765
72STK38L0.47515687
73CAMK1G0.47494553
74TEC0.46745686
75CAMK10.46210675
76PLK10.45423931
77VRK20.45182781
78PRKCQ0.45126783
79DYRK1A0.45057632
80SGK20.44574383
81NME10.43697934
82PRKACA0.43033205
83PTK2B0.42334931
84MAP2K40.40202804
85ATM0.40035400
86PRKCZ0.38463234
87TXK0.36751984
88CDK30.36045257
89SRPK10.35556920
90PASK0.35278704
91ERBB20.33493193
92MAPKAPK50.33473700
93CAMKK10.33195037
94ATR0.33093925
95MUSK0.32881017
96YES10.31868354
97MINK10.31829632
98MST40.31800725
99CSNK1D0.31742125
100SGK2230.31387770

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.17174060
2Phototransduction_Homo sapiens_hsa047442.69803200
3Butanoate metabolism_Homo sapiens_hsa006502.54907189
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.47364529
5Nicotine addiction_Homo sapiens_hsa050332.38715000
6Linoleic acid metabolism_Homo sapiens_hsa005912.37843327
7Oxidative phosphorylation_Homo sapiens_hsa001902.35176529
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.34724004
9Nitrogen metabolism_Homo sapiens_hsa009102.29726579
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.25188975
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.23765011
12Homologous recombination_Homo sapiens_hsa034402.22792160
13Selenocompound metabolism_Homo sapiens_hsa004502.00901057
14Fanconi anemia pathway_Homo sapiens_hsa034601.99174950
15RNA polymerase_Homo sapiens_hsa030201.96989456
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.95399704
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.93030369
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.90150210
19Protein export_Homo sapiens_hsa030601.88539407
20Parkinsons disease_Homo sapiens_hsa050121.80219995
21Basal transcription factors_Homo sapiens_hsa030221.79728674
22Ether lipid metabolism_Homo sapiens_hsa005651.71062112
23Tryptophan metabolism_Homo sapiens_hsa003801.61387620
24Propanoate metabolism_Homo sapiens_hsa006401.59330565
25Olfactory transduction_Homo sapiens_hsa047401.51533933
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51079930
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48132503
28RNA degradation_Homo sapiens_hsa030181.41526622
29Morphine addiction_Homo sapiens_hsa050321.35531098
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.34323048
31Huntingtons disease_Homo sapiens_hsa050161.33979625
32Caffeine metabolism_Homo sapiens_hsa002321.32944231
33One carbon pool by folate_Homo sapiens_hsa006701.31524898
34* Taste transduction_Homo sapiens_hsa047421.27338004
35Steroid biosynthesis_Homo sapiens_hsa001001.26576258
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22581071
37Non-homologous end-joining_Homo sapiens_hsa034501.20824071
38Alzheimers disease_Homo sapiens_hsa050101.18961405
39Cardiac muscle contraction_Homo sapiens_hsa042601.13244907
40Peroxisome_Homo sapiens_hsa041461.10003168
41ABC transporters_Homo sapiens_hsa020101.07944055
42Ribosome_Homo sapiens_hsa030101.03494081
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02628610
44GABAergic synapse_Homo sapiens_hsa047271.01422570
45Insulin secretion_Homo sapiens_hsa049111.00658522
46Chemical carcinogenesis_Homo sapiens_hsa052040.97882588
47Glutamatergic synapse_Homo sapiens_hsa047240.97665834
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97417502
49Regulation of autophagy_Homo sapiens_hsa041400.97392050
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.94349153
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94312246
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.92803673
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87303886
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86768056
55Circadian entrainment_Homo sapiens_hsa047130.86609106
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85790219
57beta-Alanine metabolism_Homo sapiens_hsa004100.83303486
58Retinol metabolism_Homo sapiens_hsa008300.81579973
59Collecting duct acid secretion_Homo sapiens_hsa049660.78285647
60Arachidonic acid metabolism_Homo sapiens_hsa005900.77357620
61Purine metabolism_Homo sapiens_hsa002300.77284371
62Fat digestion and absorption_Homo sapiens_hsa049750.76132233
63Serotonergic synapse_Homo sapiens_hsa047260.75904848
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74672471
65Proteasome_Homo sapiens_hsa030500.67567649
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66772667
67Vitamin digestion and absorption_Homo sapiens_hsa049770.66129182
68Glycerolipid metabolism_Homo sapiens_hsa005610.64488756
69Calcium signaling pathway_Homo sapiens_hsa040200.62166786
70Metabolic pathways_Homo sapiens_hsa011000.61636721
71Nucleotide excision repair_Homo sapiens_hsa034200.60267667
72Hedgehog signaling pathway_Homo sapiens_hsa043400.58926462
73Pyrimidine metabolism_Homo sapiens_hsa002400.58705502
74Basal cell carcinoma_Homo sapiens_hsa052170.58291710
75Histidine metabolism_Homo sapiens_hsa003400.58242189
76Cocaine addiction_Homo sapiens_hsa050300.57584035
77Dopaminergic synapse_Homo sapiens_hsa047280.56604855
78Dorso-ventral axis formation_Homo sapiens_hsa043200.54699819
79Salivary secretion_Homo sapiens_hsa049700.54183805
80Ovarian steroidogenesis_Homo sapiens_hsa049130.53643837
81RNA transport_Homo sapiens_hsa030130.53027073
82Sulfur relay system_Homo sapiens_hsa041220.52732306
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.52695794
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51338902
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48233267
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47262897
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44868104
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44256065
89Axon guidance_Homo sapiens_hsa043600.42733183
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41406065
91Sulfur metabolism_Homo sapiens_hsa009200.40777780
92Circadian rhythm_Homo sapiens_hsa047100.40372545
93Amphetamine addiction_Homo sapiens_hsa050310.39539006
94Mismatch repair_Homo sapiens_hsa034300.39303020
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.37886975
96Arginine and proline metabolism_Homo sapiens_hsa003300.37642743
97Mineral absorption_Homo sapiens_hsa049780.36577529
98Fatty acid metabolism_Homo sapiens_hsa012120.34519098
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34292353
100Fatty acid degradation_Homo sapiens_hsa000710.33278481

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