TAS2R30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1monoubiquitinated protein deubiquitination (GO:0035520)5.48887502
2establishment of protein localization to Golgi (GO:0072600)4.56909059
3regulation of pigment cell differentiation (GO:0050932)4.48787264
4positive regulation of developmental pigmentation (GO:0048087)4.41590246
5phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.40027279
6nuclear pore complex assembly (GO:0051292)4.39404994
7neural tube formation (GO:0001841)4.38513221
8* detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.36724469
9cytoplasmic mRNA processing body assembly (GO:0033962)4.35533237
10interkinetic nuclear migration (GO:0022027)4.35516270
11histone mRNA catabolic process (GO:0071044)4.26892252
12negative regulation of translation, ncRNA-mediated (GO:0040033)4.24319436
13regulation of translation, ncRNA-mediated (GO:0045974)4.24319436
14negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.24319436
15protein prenylation (GO:0018342)4.18844900
16prenylation (GO:0097354)4.18844900
17cellular response to ethanol (GO:0071361)4.10798706
18cerebellar Purkinje cell differentiation (GO:0021702)3.85813607
19protein targeting to Golgi (GO:0000042)3.84780411
20nuclear pore organization (GO:0006999)3.82446838
21microtubule anchoring (GO:0034453)3.81348942
22retrograde transport, vesicle recycling within Golgi (GO:0000301)3.71473632
23histone H3-K4 trimethylation (GO:0080182)3.70014430
24nucleus localization (GO:0051647)3.68308761
25* detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.57673738
26proline transport (GO:0015824)3.57470195
27peptidyl-lysine trimethylation (GO:0018023)3.44806596
28embryonic retina morphogenesis in camera-type eye (GO:0060059)3.42387847
29protein K11-linked deubiquitination (GO:0035871)3.42021320
30phospholipid translocation (GO:0045332)3.33916454
31lipid translocation (GO:0034204)3.33916454
32negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.33344128
33establishment of nucleus localization (GO:0040023)3.16582160
34protein K48-linked deubiquitination (GO:0071108)3.16317067
35pore complex assembly (GO:0046931)3.16201350
36central nervous system neuron axonogenesis (GO:0021955)3.14710069
37protein targeting to vacuole (GO:0006623)3.14050415
38protein targeting to lysosome (GO:0006622)3.14050415
39establishment of protein localization to vacuole (GO:0072666)3.14050415
40snRNA transcription (GO:0009301)3.11655423
41regulation of establishment of cell polarity (GO:2000114)3.08403312
42mitotic sister chromatid cohesion (GO:0007064)3.08023658
43negative regulation of neurotransmitter transport (GO:0051589)3.07231115
44pericardium development (GO:0060039)3.05087776
45pre-miRNA processing (GO:0031054)3.03926868
46regulation of sarcomere organization (GO:0060297)2.96834849
47Golgi to endosome transport (GO:0006895)2.92907663
48protein localization to Golgi apparatus (GO:0034067)2.87004189
49response to pheromone (GO:0019236)2.84143345
50central nervous system projection neuron axonogenesis (GO:0021952)2.80132556
51cAMP catabolic process (GO:0006198)2.78851639
52negative regulation of neurotransmitter secretion (GO:0046929)2.77133215
53regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.75479733
54detection of light stimulus involved in visual perception (GO:0050908)2.74657983
55detection of light stimulus involved in sensory perception (GO:0050962)2.74657983
56regulation of MHC class I biosynthetic process (GO:0045343)2.72282252
57protein K63-linked deubiquitination (GO:0070536)2.70690496
58RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.69449048
59peptidyl-lysine methylation (GO:0018022)2.68247665
60regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.67733957
61positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.67733957
62positive regulation of cell cycle checkpoint (GO:1901978)2.67589126
63nerve growth factor signaling pathway (GO:0038180)2.66193688
64cyclic nucleotide catabolic process (GO:0009214)2.65695489
65oocyte development (GO:0048599)2.64135279
66negative regulation of DNA repair (GO:0045738)2.60064959
67tachykinin receptor signaling pathway (GO:0007217)2.58897933
68centrosome localization (GO:0051642)2.58048070
69definitive hemopoiesis (GO:0060216)2.56950566
70somite rostral/caudal axis specification (GO:0032525)2.55809341
71regulation of establishment or maintenance of cell polarity (GO:0032878)2.54114738
72regulation of DNA endoreduplication (GO:0032875)2.53547416
73gastrulation with mouth forming second (GO:0001702)2.53348752
74fibroblast migration (GO:0010761)2.52398863
75retina layer formation (GO:0010842)2.51098132
76positive regulation of granulocyte differentiation (GO:0030854)2.49316930
77retinal cone cell development (GO:0046549)2.49043976
78rRNA catabolic process (GO:0016075)2.48195880
79regulation of centrosome duplication (GO:0010824)2.46932729
80intra-Golgi vesicle-mediated transport (GO:0006891)2.44037000
81early endosome to late endosome transport (GO:0045022)2.43667079
82histone lysine methylation (GO:0034968)2.41250511
83positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.39927676
84sympathetic nervous system development (GO:0048485)2.39432365
85regulation of centriole replication (GO:0046599)2.38922836
86protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.38670547
87DNA integration (GO:0015074)2.35793530
88regulation of relaxation of muscle (GO:1901077)2.35238092
89detection of molecule of bacterial origin (GO:0032490)2.34445430
90genitalia morphogenesis (GO:0035112)2.33722370
91neurotransmitter-gated ion channel clustering (GO:0072578)2.33185669
92regulation of mitotic spindle checkpoint (GO:1903504)2.32542198
93regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.32542198
94inositol metabolic process (GO:0006020)2.32139135
95regulation of protein glycosylation (GO:0060049)2.31851018
96positive regulation of phosphatase activity (GO:0010922)2.31163519
97negative regulation of cytosolic calcium ion concentration (GO:0051481)2.30086681
98positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.29457849
99regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.29457849
100G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.28741267

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.30371050
2POU3F2_20337985_ChIP-ChIP_501MEL_Human3.23646090
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.18608841
4GBX2_23144817_ChIP-Seq_PC3_Human2.99743815
5TAF15_26573619_Chip-Seq_HEK293_Human2.80471897
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.73754469
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.63045406
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.61622257
9SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.39114582
10AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.35388295
11EWS_26573619_Chip-Seq_HEK293_Human2.33050229
12FUS_26573619_Chip-Seq_HEK293_Human2.30907833
13IGF1R_20145208_ChIP-Seq_DFB_Human2.23633445
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19138783
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14355258
16P300_19829295_ChIP-Seq_ESCs_Human2.10776490
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.08891513
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00145371
19SMAD4_21799915_ChIP-Seq_A2780_Human1.98199159
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.95411470
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.92795522
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.90479464
23STAT3_23295773_ChIP-Seq_U87_Human1.89758464
24MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.84716576
25ZNF274_21170338_ChIP-Seq_K562_Hela1.82848978
26OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80383152
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74641003
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74197788
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73247235
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.72610656
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69632050
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.67526251
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67526251
34TCF4_23295773_ChIP-Seq_U87_Human1.65461764
35TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.63282087
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.62918782
37ER_23166858_ChIP-Seq_MCF-7_Human1.60621013
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57054766
39AR_21572438_ChIP-Seq_LNCaP_Human1.55665064
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.54716838
41TP53_16413492_ChIP-PET_HCT116_Human1.54426679
42TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.54235973
43VDR_22108803_ChIP-Seq_LS180_Human1.53035749
44GATA1_22025678_ChIP-Seq_K562_Human1.51903096
45NANOG_18555785_Chip-Seq_ESCs_Mouse1.51748299
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51493638
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50530357
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49736783
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49202009
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48440707
51* CBP_20019798_ChIP-Seq_JUKART_Human1.47479532
52* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47479532
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46719547
54CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.45774903
55E2F1_18555785_Chip-Seq_ESCs_Mouse1.44729354
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42110312
57FLI1_21867929_ChIP-Seq_TH2_Mouse1.41355759
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.41127814
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38318372
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37614120
61AR_25329375_ChIP-Seq_VCAP_Human1.37344359
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37075069
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36120729
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32278067
65FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31393929
66AHR_22903824_ChIP-Seq_MCF-7_Human1.31245622
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.30490339
68P53_22387025_ChIP-Seq_ESCs_Mouse1.27268419
69BCAT_22108803_ChIP-Seq_LS180_Human1.27083687
70RUNX2_22187159_ChIP-Seq_PCA_Human1.25045366
71CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.24616256
72TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.24532702
73CMYC_18555785_Chip-Seq_ESCs_Mouse1.21230943
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20436284
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20436284
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.20170858
77SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18828031
78OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17850619
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17050211
80TCF4_22108803_ChIP-Seq_LS180_Human1.16977235
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.15753345
82CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15035375
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.14857663
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12660457
85KDM2B_26808549_Chip-Seq_REH_Human1.11713654
86TP53_18474530_ChIP-ChIP_U2OS_Human1.11379872
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11308267
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11115975
89P300_18555785_Chip-Seq_ESCs_Mouse1.07174429
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.05907894
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05186291
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04074884
93RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03923668
94CDX2_22108803_ChIP-Seq_LS180_Human1.02484300
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02284872
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.02065879
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01408893
98RXR_22108803_ChIP-Seq_LS180_Human1.00461407
99TCF4_18268006_ChIP-ChIP_LS174T_Human0.98995146
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98803996

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.91392193
2MP0008057_abnormal_DNA_replication6.33463183
3MP0003890_abnormal_embryonic-extraembry3.81496791
4MP0005174_abnormal_tail_pigmentation2.19720917
5MP0002009_preneoplasia2.00616220
6MP0000015_abnormal_ear_pigmentation1.96655302
7MP0005187_abnormal_penis_morphology1.89078664
8MP0003787_abnormal_imprinting1.83133984
9MP0002095_abnormal_skin_pigmentation1.69074860
10MP0002102_abnormal_ear_morphology1.65156281
11MP0010386_abnormal_urinary_bladder1.61087826
12MP0009046_muscle_twitch1.59589330
13MP0008877_abnormal_DNA_methylation1.53599208
14MP0004145_abnormal_muscle_electrophysio1.52834618
15MP0003880_abnormal_central_pattern1.48787555
16MP0005253_abnormal_eye_physiology1.48225962
17MP0006292_abnormal_olfactory_placode1.46877966
18MP0000383_abnormal_hair_follicle1.43421043
19MP0004381_abnormal_hair_follicle1.43244690
20MP0003183_abnormal_peptide_metabolism1.42991876
21MP0000427_abnormal_hair_cycle1.41852924
22MP0000778_abnormal_nervous_system1.39777749
23MP0002332_abnormal_exercise_endurance1.39524054
24MP0006276_abnormal_autonomic_nervous1.39270872
25MP0002396_abnormal_hematopoietic_system1.37721244
26MP0005386_behavior/neurological_phenoty1.28155317
27MP0004924_abnormal_behavior1.28155317
28MP0006054_spinal_hemorrhage1.27653512
29MP0005551_abnormal_eye_electrophysiolog1.26182845
30MP0002751_abnormal_autonomic_nervous1.24280979
31MP0005266_abnormal_metabolism1.21953464
32MP0005075_abnormal_melanosome_morpholog1.21784130
33MP0000516_abnormal_urinary_system1.21720163
34MP0005367_renal/urinary_system_phenotyp1.21720163
35MP0002928_abnormal_bile_duct1.20493324
36MP0009697_abnormal_copulation1.20371612
37MP0003045_fibrosis1.19839904
38MP0003121_genomic_imprinting1.19459193
39MP0010678_abnormal_skin_adnexa1.16663922
40MP0004142_abnormal_muscle_tone1.15305734
41MP0002837_dystrophic_cardiac_calcinosis1.13526182
42MP0002638_abnormal_pupillary_reflex1.13066951
43MP0001486_abnormal_startle_reflex1.12091696
44MP0003937_abnormal_limbs/digits/tail_de1.11718755
45MP0001984_abnormal_olfaction1.10828621
46MP0001879_abnormal_lymphatic_vessel1.10123787
47MP0002168_other_aberrant_phenotype1.07960379
48MP0010352_gastrointestinal_tract_polyps1.07888965
49MP0004484_altered_response_of1.06715117
50MP0008058_abnormal_DNA_repair1.06324987
51MP0003646_muscle_fatigue1.06190574
52MP0003195_calcinosis1.05941577
53MP0003221_abnormal_cardiomyocyte_apopto1.05362078
54MP0004215_abnormal_myocardial_fiber1.04993429
55MP0005248_abnormal_Harderian_gland1.03567779
56MP0002067_abnormal_sensory_capabilities1.02694042
57MP0000372_irregular_coat_pigmentation1.01518831
58MP0000371_diluted_coat_color0.99829949
59MP0010307_abnormal_tumor_latency0.97892065
60MP0003632_abnormal_nervous_system0.95694877
61MP0003252_abnormal_bile_duct0.95548000
62MP0003633_abnormal_nervous_system0.94335462
63MP0001286_abnormal_eye_development0.94183435
64MP0003935_abnormal_craniofacial_develop0.91119961
65MP0004808_abnormal_hematopoietic_stem0.90642145
66MP0008961_abnormal_basal_metabolism0.90607072
67MP0005171_absent_coat_pigmentation0.88169533
68MP0002184_abnormal_innervation0.88024644
69MP0002272_abnormal_nervous_system0.87406363
70MP0003631_nervous_system_phenotype0.86908966
71MP0005220_abnormal_exocrine_pancreas0.86471537
72MP0002127_abnormal_cardiovascular_syste0.86169372
73MP0006072_abnormal_retinal_apoptosis0.85471111
74MP0003136_yellow_coat_color0.84242304
75MP0008995_early_reproductive_senescence0.83893763
76MP0005391_vision/eye_phenotype0.81994351
77MP0003943_abnormal_hepatobiliary_system0.81467420
78MP0004084_abnormal_cardiac_muscle0.81323291
79MP0000955_abnormal_spinal_cord0.81191042
80MP0005645_abnormal_hypothalamus_physiol0.80899881
81MP0005083_abnormal_biliary_tract0.80890317
82MP0000631_abnormal_neuroendocrine_gland0.80544696
83MP0002736_abnormal_nociception_after0.79847510
84MP0001968_abnormal_touch/_nociception0.79772943
85MP0005395_other_phenotype0.78205803
86MP0001501_abnormal_sleep_pattern0.78080953
87MP0010094_abnormal_chromosome_stability0.76896512
88MP0002882_abnormal_neuron_morphology0.75993205
89MP0003656_abnormal_erythrocyte_physiolo0.75688204
90MP0003119_abnormal_digestive_system0.74490240
91MP0000647_abnormal_sebaceous_gland0.74380723
92MP0001177_atelectasis0.73998418
93MP0009745_abnormal_behavioral_response0.73172517
94MP0003077_abnormal_cell_cycle0.72855442
95MP0003868_abnormal_feces_composition0.72263193
96MP0005409_darkened_coat_color0.71755010
97MP0002088_abnormal_embryonic_growth/wei0.71547466
98MP0005379_endocrine/exocrine_gland_phen0.70793182
99MP0001293_anophthalmia0.70214899
100MP0001324_abnormal_eye_pigmentation0.69180250

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)3.87924066
2Hyperventilation (HP:0002883)3.83553043
3Febrile seizures (HP:0002373)3.70333083
4Fair hair (HP:0002286)3.68113860
5Gaze-evoked nystagmus (HP:0000640)3.64820601
6Volvulus (HP:0002580)3.38202412
7Genetic anticipation (HP:0003743)3.32703209
8Protruding tongue (HP:0010808)3.06330886
9Astrocytoma (HP:0009592)2.88166530
10Abnormality of the astrocytes (HP:0100707)2.88166530
11Widely spaced teeth (HP:0000687)2.85732397
12Hepatoblastoma (HP:0002884)2.79719640
13Generalized hypopigmentation of hair (HP:0011358)2.76259610
14Diastasis recti (HP:0001540)2.75496620
15Progressive cerebellar ataxia (HP:0002073)2.70283714
16Chronic hepatic failure (HP:0100626)2.68715156
17Aplasia/Hypoplasia of the tibia (HP:0005772)2.67658733
18Acute myeloid leukemia (HP:0004808)2.66242285
19Drooling (HP:0002307)2.64105815
20Medulloblastoma (HP:0002885)2.60802351
21Tubulointerstitial nephritis (HP:0001970)2.59164594
22Short chin (HP:0000331)2.56124008
23Submucous cleft hard palate (HP:0000176)2.54263837
24Glioma (HP:0009733)2.53850179
25Thyroid carcinoma (HP:0002890)2.51893294
26Pancreatic cysts (HP:0001737)2.44689027
27Truncal obesity (HP:0001956)2.40297853
28Excessive salivation (HP:0003781)2.38826672
29Broad-based gait (HP:0002136)2.38694423
30Subacute progressive viral hepatitis (HP:0006572)2.37066293
31Abnormality of chromosome stability (HP:0003220)2.36978577
32Thyroiditis (HP:0100646)2.32196005
33Abnormality of the renal cortex (HP:0011035)2.32003238
34Thoracolumbar scoliosis (HP:0002944)2.26036994
35Cupped ear (HP:0000378)2.23807278
36Sandal gap (HP:0001852)2.23331219
37Rhabdomyosarcoma (HP:0002859)2.21047469
38Blue irides (HP:0000635)2.19669974
39Absent speech (HP:0001344)2.19535559
40Intestinal atresia (HP:0011100)2.19278710
41Renal cortical cysts (HP:0000803)2.12776074
42Abnormality of the renal medulla (HP:0100957)2.11403960
43Hip dysplasia (HP:0001385)2.04182579
44Abnormality of midbrain morphology (HP:0002418)2.00666859
45Molar tooth sign on MRI (HP:0002419)2.00666859
46Nephronophthisis (HP:0000090)1.99993968
47Neoplasm of striated muscle (HP:0009728)1.99931785
48Acanthocytosis (HP:0001927)1.98752105
49Curly hair (HP:0002212)1.98215178
50Hypoplastic labia majora (HP:0000059)1.96518780
51Oligodactyly (hands) (HP:0001180)1.95783267
52Abnormality of the fingertips (HP:0001211)1.95238159
53Ependymoma (HP:0002888)1.94832613
54Long clavicles (HP:0000890)1.93187683
55Small hand (HP:0200055)1.91692056
56Pancreatic fibrosis (HP:0100732)1.91571286
57Abnormal pancreas size (HP:0012094)1.90589497
58Broad ribs (HP:0000885)1.88303207
59Abnormality of the labia majora (HP:0012881)1.88254525
60Colon cancer (HP:0003003)1.88209957
61Poor coordination (HP:0002370)1.85746124
62Tented upper lip vermilion (HP:0010804)1.85101079
63Depressed nasal tip (HP:0000437)1.84998962
64Atonic seizures (HP:0010819)1.82803916
65Highly arched eyebrow (HP:0002553)1.82590942
66Clumsiness (HP:0002312)1.80910200
67True hermaphroditism (HP:0010459)1.80865368
68Short foot (HP:0001773)1.79280047
69Exotropia (HP:0000577)1.78799539
70Hypoplastic iliac wings (HP:0002866)1.78664400
71Aqueductal stenosis (HP:0002410)1.78338415
72Abnormality of the nasal septum (HP:0000419)1.77570958
73Heterotopia (HP:0002282)1.76722985
74Cerebellar dysplasia (HP:0007033)1.76718968
75Thick eyebrow (HP:0000574)1.76424437
76Tubulointerstitial abnormality (HP:0001969)1.74943260
77Prominent nose (HP:0000448)1.74648203
78T lymphocytopenia (HP:0005403)1.73978136
79Neoplasm of the adrenal cortex (HP:0100641)1.72953446
80Narrow palate (HP:0000189)1.72890217
81Neoplasm of the small intestine (HP:0100833)1.72406774
82Chin dimple (HP:0010751)1.70969128
83Focal motor seizures (HP:0011153)1.70074080
84Narrow forehead (HP:0000341)1.69833680
85Midline defect of the nose (HP:0004122)1.68600134
86Clubbing of toes (HP:0100760)1.68439178
87Medial flaring of the eyebrow (HP:0010747)1.67669627
88Focal seizures (HP:0007359)1.66806910
89Bifid tongue (HP:0010297)1.66768465
90Viral hepatitis (HP:0006562)1.66759036
91Stomach cancer (HP:0012126)1.65988282
92Macroorchidism (HP:0000053)1.65440887
93Short tibia (HP:0005736)1.65320452
94Neoplasm of the heart (HP:0100544)1.65219695
95Astigmatism (HP:0000483)1.64271775
96Postaxial foot polydactyly (HP:0001830)1.63871859
97Neonatal hypoglycemia (HP:0001998)1.62935684
98Neoplasm of the oral cavity (HP:0100649)1.62546500
99Hypopigmentation of the fundus (HP:0007894)1.62534884
100Chromsome breakage (HP:0040012)1.60633524

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.32538015
2MAP3K43.24103956
3ACVR1B3.00492648
4AKT32.95184569
5INSRR2.62017025
6BMPR1B2.51958017
7CASK2.49950025
8TRIM282.10816364
9MAP4K22.04085440
10MKNK21.89873551
11BCR1.84433096
12STK38L1.80177202
13BRD41.76510018
14LATS11.69778259
15MAP2K71.67255072
16SGK21.60342994
17ERBB31.59891916
18NUAK11.58884826
19MAP2K41.52540705
20PKN21.48823929
21OBSCN1.44951720
22MAP3K61.42064119
23WNK31.41021779
24FLT31.40138871
25MAPK131.39254051
26CAMKK21.31636204
27BLK1.12990306
28WNK11.11923882
29PAK31.10329853
30TEC1.09534450
31NTRK31.08371207
32PIK3CA1.06734010
33CAMK1D1.06074952
34SRPK11.03829434
35MAP3K21.03807405
36MKNK11.02042524
37OXSR11.01780120
38ZAK1.01407728
39MARK11.01186108
40CAMK1G0.98736657
41NLK0.95567842
42PLK20.93122901
43DYRK1A0.92812935
44PIK3CG0.89162173
45EIF2AK30.88319673
46FGFR30.85405753
47SGK30.83597053
48TGFBR10.83075339
49SGK4940.82877045
50SGK2230.82877045
51NEK60.80249609
52BRSK20.77473795
53CDK120.75704970
54STK390.75327189
55KSR10.74056961
56SGK10.72474199
57CAMK40.71787357
58EPHA40.70636029
59CSNK1A1L0.69487392
60TRPM70.68738297
61ADRBK20.67392712
62TAOK30.63764364
63IRAK10.63454721
64BMPR20.63447436
65CDK30.63392275
66ERBB20.63164334
67DYRK30.62337508
68TAF10.61924315
69ATM0.61349276
70YES10.60942643
71MELK0.60474335
72CSNK1G10.59653895
73STK380.59306950
74VRK10.55695970
75ADRBK10.54914683
76MAPK70.50502038
77CHUK0.48149903
78MAP3K50.48058111
79FER0.47507523
80RET0.46560610
81PRKG10.46398169
82PDGFRB0.46195438
83FGFR10.45812220
84PRKCE0.45029612
85FGFR20.44346034
86TNIK0.44277682
87PTK2B0.43554811
88CSNK1D0.42735418
89PIM10.41934458
90PDK20.41870510
91ATR0.41555203
92MAP3K100.38475030
93TLK10.38446211
94PRKACB0.37558018
95SYK0.37338222
96CSNK1G20.36495884
97EGFR0.36281552
98STK30.36270123
99STK40.34996928
100RPS6KA50.34115963

Predicted pathways (KEGG)

RankGene SetZ-score
1* Taste transduction_Homo sapiens_hsa047422.99874361
2Nicotine addiction_Homo sapiens_hsa050332.26450401
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.25046913
4Dorso-ventral axis formation_Homo sapiens_hsa043202.17614309
5Systemic lupus erythematosus_Homo sapiens_hsa053222.04060099
6Circadian rhythm_Homo sapiens_hsa047101.88582379
7Fanconi anemia pathway_Homo sapiens_hsa034601.78010243
8Alcoholism_Homo sapiens_hsa050341.66268050
9Non-homologous end-joining_Homo sapiens_hsa034501.65834956
10Phosphatidylinositol signaling system_Homo sapiens_hsa040701.64429645
11Type II diabetes mellitus_Homo sapiens_hsa049301.58255905
12Lysine degradation_Homo sapiens_hsa003101.52712620
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.52144711
14Glutamatergic synapse_Homo sapiens_hsa047241.48613011
15RNA degradation_Homo sapiens_hsa030181.48519553
16Colorectal cancer_Homo sapiens_hsa052101.39785445
17TGF-beta signaling pathway_Homo sapiens_hsa043501.38365800
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38219186
19Basal transcription factors_Homo sapiens_hsa030221.34748911
20Long-term depression_Homo sapiens_hsa047301.33342102
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31158608
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.30786180
23FoxO signaling pathway_Homo sapiens_hsa040681.30024450
24Morphine addiction_Homo sapiens_hsa050321.16854624
25Cholinergic synapse_Homo sapiens_hsa047251.15164571
26Circadian entrainment_Homo sapiens_hsa047131.12115161
27Calcium signaling pathway_Homo sapiens_hsa040201.11357908
28Renin secretion_Homo sapiens_hsa049241.11128256
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06590617
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05632195
31Dopaminergic synapse_Homo sapiens_hsa047281.04991038
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04944950
33ABC transporters_Homo sapiens_hsa020101.04681034
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04225617
35Phototransduction_Homo sapiens_hsa047441.03210670
36Olfactory transduction_Homo sapiens_hsa047401.03051776
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01186173
38Salivary secretion_Homo sapiens_hsa049700.99059763
39Steroid hormone biosynthesis_Homo sapiens_hsa001400.97206911
40Inositol phosphate metabolism_Homo sapiens_hsa005620.96727237
41MicroRNAs in cancer_Homo sapiens_hsa052060.96366355
42Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95683622
43p53 signaling pathway_Homo sapiens_hsa041150.94255534
44GABAergic synapse_Homo sapiens_hsa047270.94149676
45Nitrogen metabolism_Homo sapiens_hsa009100.94080233
46Prolactin signaling pathway_Homo sapiens_hsa049170.93823181
47ErbB signaling pathway_Homo sapiens_hsa040120.91888178
48cAMP signaling pathway_Homo sapiens_hsa040240.90416644
49Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89808042
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89463389
51Insulin secretion_Homo sapiens_hsa049110.89314694
52Selenocompound metabolism_Homo sapiens_hsa004500.89120647
53Regulation of autophagy_Homo sapiens_hsa041400.86410684
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86097752
55Choline metabolism in cancer_Homo sapiens_hsa052310.85449681
56mTOR signaling pathway_Homo sapiens_hsa041500.83479662
57Butanoate metabolism_Homo sapiens_hsa006500.82065329
58Serotonergic synapse_Homo sapiens_hsa047260.81973815
59Platelet activation_Homo sapiens_hsa046110.81376754
60mRNA surveillance pathway_Homo sapiens_hsa030150.81335361
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.81022506
62Homologous recombination_Homo sapiens_hsa034400.80951670
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80823142
64Prostate cancer_Homo sapiens_hsa052150.80255462
65Non-small cell lung cancer_Homo sapiens_hsa052230.78321038
66Protein export_Homo sapiens_hsa030600.74877463
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74681328
68Glioma_Homo sapiens_hsa052140.74143947
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73137904
70Long-term potentiation_Homo sapiens_hsa047200.72225499
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71937020
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.70650428
73Amphetamine addiction_Homo sapiens_hsa050310.70028770
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69590014
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69183824
76Cocaine addiction_Homo sapiens_hsa050300.66074775
77Viral carcinogenesis_Homo sapiens_hsa052030.65842531
78Oxytocin signaling pathway_Homo sapiens_hsa049210.65350394
79Pancreatic cancer_Homo sapiens_hsa052120.64370132
80Propanoate metabolism_Homo sapiens_hsa006400.62805845
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60422203
82Melanoma_Homo sapiens_hsa052180.58014536
83Endometrial cancer_Homo sapiens_hsa052130.57523228
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57333114
85Oocyte meiosis_Homo sapiens_hsa041140.56993561
86Axon guidance_Homo sapiens_hsa043600.55701347
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55576274
88Insulin resistance_Homo sapiens_hsa049310.54496253
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53769120
90Glucagon signaling pathway_Homo sapiens_hsa049220.52683566
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50735439
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50480311
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48612717
94Cell cycle_Homo sapiens_hsa041100.47945398
95Adherens junction_Homo sapiens_hsa045200.45933437
96Retinol metabolism_Homo sapiens_hsa008300.45093808
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43346865
98Fatty acid biosynthesis_Homo sapiens_hsa000610.41837168
99Gastric acid secretion_Homo sapiens_hsa049710.41655407
100Wnt signaling pathway_Homo sapiens_hsa043100.41317312

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