TAS2R15P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal cone cell development (GO:0046549)5.76480396
2negative regulation of DNA recombination (GO:0045910)5.42104720
3DNA double-strand break processing (GO:0000729)4.71158325
4pyrimidine nucleobase catabolic process (GO:0006208)4.41472609
5neurofilament cytoskeleton organization (GO:0060052)4.30783564
6protein localization to synapse (GO:0035418)4.05975233
7fatty acid elongation (GO:0030497)3.87998998
8negative regulation of axon guidance (GO:1902668)3.73248569
9acrosome reaction (GO:0007340)3.57202251
10retinal ganglion cell axon guidance (GO:0031290)3.56256369
11detection of light stimulus involved in visual perception (GO:0050908)3.53927685
12detection of light stimulus involved in sensory perception (GO:0050962)3.53927685
13detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.51088471
14nucleobase catabolic process (GO:0046113)3.49899434
15gamma-aminobutyric acid transport (GO:0015812)3.45891262
16response to pheromone (GO:0019236)3.42789331
17resolution of meiotic recombination intermediates (GO:0000712)3.42104044
18glycosphingolipid biosynthetic process (GO:0006688)3.31995139
19neuron cell-cell adhesion (GO:0007158)3.20560156
20regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.19926667
21presynaptic membrane assembly (GO:0097105)3.18613334
22regulation of double-strand break repair via homologous recombination (GO:0010569)3.17134436
23neuronal action potential propagation (GO:0019227)3.16668468
24ribonucleoprotein complex disassembly (GO:0032988)3.14032489
25regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.10266705
26regulation of mitotic spindle checkpoint (GO:1903504)3.10266705
27serotonin metabolic process (GO:0042428)3.06714756
28auditory behavior (GO:0031223)3.03610308
29synaptic vesicle endocytosis (GO:0048488)3.01380820
30metaphase plate congression (GO:0051310)3.01377722
31anterograde axon cargo transport (GO:0008089)2.98478958
32mechanosensory behavior (GO:0007638)2.95921945
33histone H2A acetylation (GO:0043968)2.92638503
34photoreceptor cell development (GO:0042461)2.87794435
35detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.86899333
36eye photoreceptor cell development (GO:0042462)2.85550964
37postsynaptic membrane organization (GO:0001941)2.84366916
38respiratory chain complex IV assembly (GO:0008535)2.83764027
39replication fork processing (GO:0031297)2.83634411
40neuron projection extension involved in neuron projection guidance (GO:1902284)2.83522833
41axon extension involved in axon guidance (GO:0048846)2.83522833
42organelle disassembly (GO:1903008)2.80890636
43intraciliary transport (GO:0042073)2.80843925
44protein-cofactor linkage (GO:0018065)2.80566637
45prostate gland growth (GO:0060736)2.77229948
46positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.76518126
47limb bud formation (GO:0060174)2.75997189
48primary amino compound metabolic process (GO:1901160)2.74202025
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72621774
50microtubule depolymerization (GO:0007019)2.72615378
51presynaptic membrane organization (GO:0097090)2.72551267
52regulation of chemokine-mediated signaling pathway (GO:0070099)2.72026468
53anterograde synaptic vesicle transport (GO:0048490)2.72014979
54axonal fasciculation (GO:0007413)2.70073519
55negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.69583698
56synaptic vesicle transport (GO:0048489)2.68742457
57establishment of synaptic vesicle localization (GO:0097480)2.68742457
58regulation of centriole replication (GO:0046599)2.67395110
59DNA integration (GO:0015074)2.62174380
60regulation of telomere maintenance (GO:0032204)2.61400671
61negative regulation of Rho protein signal transduction (GO:0035024)2.61071943
62microtubule anchoring (GO:0034453)2.61058192
63peroxisome fission (GO:0016559)2.60152999
64negative regulation of microtubule depolymerization (GO:0007026)2.58697030
65calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.57986246
66protein K6-linked ubiquitination (GO:0085020)2.57319591
67sequestering of actin monomers (GO:0042989)2.56452470
68microtubule polymerization or depolymerization (GO:0031109)2.55990728
69negative regulation of cytosolic calcium ion concentration (GO:0051481)2.55948636
70positive regulation of mRNA processing (GO:0050685)2.55871792
71regulation of voltage-gated calcium channel activity (GO:1901385)2.55294195
72neural tube formation (GO:0001841)2.54832691
73protein prenylation (GO:0018342)2.54715749
74prenylation (GO:0097354)2.54715749
75synapse assembly (GO:0007416)2.53428841
76regulation of spindle organization (GO:0090224)2.52487800
77somatic diversification of immune receptors via somatic mutation (GO:0002566)2.51987377
78somatic hypermutation of immunoglobulin genes (GO:0016446)2.51987377
79establishment of vesicle localization (GO:0051650)2.51927482
80DNA strand renaturation (GO:0000733)2.49912985
81hippocampus development (GO:0021766)2.49581408
82protein localization to chromosome (GO:0034502)2.49515875
83somite development (GO:0061053)2.49020839
84cytoskeleton-dependent intracellular transport (GO:0030705)2.47948196
85spindle checkpoint (GO:0031577)2.47901239
86negative regulation of DNA-dependent DNA replication (GO:2000104)2.45624159
87regulation of axon guidance (GO:1902667)2.45490807
88neuron-neuron synaptic transmission (GO:0007270)2.44166274
89spermatid nucleus differentiation (GO:0007289)2.43734402
90photoreceptor cell maintenance (GO:0045494)2.42972137
91regulation of relaxation of muscle (GO:1901077)2.42618240
92peptidyl-cysteine modification (GO:0018198)2.42613845
93protein localization to kinetochore (GO:0034501)2.42322283
94centriole replication (GO:0007099)2.42236085
95histone mRNA catabolic process (GO:0071044)2.42002684
96regulation of microtubule depolymerization (GO:0031114)2.40529798
97nonmotile primary cilium assembly (GO:0035058)2.39852260
98negative regulation of telomere maintenance (GO:0032205)2.39705835
99synaptic vesicle exocytosis (GO:0016079)2.38939951
100postreplication repair (GO:0006301)2.38319151

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.64121908
2GBX2_23144817_ChIP-Seq_PC3_Human3.44110120
3POU3F2_20337985_ChIP-ChIP_501MEL_Human3.14406758
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.97360186
5TAF15_26573619_Chip-Seq_HEK293_Human2.88056965
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.81979746
7IGF1R_20145208_ChIP-Seq_DFB_Human2.62890646
8ZNF274_21170338_ChIP-Seq_K562_Hela2.56310027
9FUS_26573619_Chip-Seq_HEK293_Human2.40235746
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.38669817
11VDR_22108803_ChIP-Seq_LS180_Human2.26063927
12P300_19829295_ChIP-Seq_ESCs_Human2.19494873
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09945072
14EZH2_22144423_ChIP-Seq_EOC_Human2.05389739
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.04961862
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.04906132
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04593740
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04553597
19EWS_26573619_Chip-Seq_HEK293_Human2.02651182
20SMAD4_21799915_ChIP-Seq_A2780_Human1.92120838
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.90871353
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89690855
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86929036
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82263382
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81019759
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.79900411
27FOXM1_23109430_ChIP-Seq_U2OS_Human1.79492145
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73141203
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72374972
30OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68484023
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65114244
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.64975223
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.62514799
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61159705
35STAT3_23295773_ChIP-Seq_U87_Human1.60953610
36HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.60811440
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57050859
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55679406
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52405325
40NANOG_18555785_Chip-Seq_ESCs_Mouse1.52246722
41ELK1_19687146_ChIP-ChIP_HELA_Human1.52188509
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50193381
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.49718119
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.49201507
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48645085
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45183047
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44262771
48ER_23166858_ChIP-Seq_MCF-7_Human1.43237102
49TCF4_23295773_ChIP-Seq_U87_Human1.42030006
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41368434
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40313542
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39463566
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39328814
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37291724
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37016417
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36727412
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36361120
58JUN_21703547_ChIP-Seq_K562_Human1.36093057
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.33669079
60AR_25329375_ChIP-Seq_VCAP_Human1.33448226
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31791516
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31440479
63BCAT_22108803_ChIP-Seq_LS180_Human1.30647048
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29418760
65CBP_20019798_ChIP-Seq_JUKART_Human1.29418760
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.26471692
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.25003816
68AR_21572438_ChIP-Seq_LNCaP_Human1.23738860
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23447522
70GABP_17652178_ChIP-ChIP_JURKAT_Human1.22341824
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19812844
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19147818
73P53_22387025_ChIP-Seq_ESCs_Mouse1.19018221
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18882348
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18060913
76RUNX2_22187159_ChIP-Seq_PCA_Human1.17447201
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17319184
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.16661631
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.15701014
80RNF2_27304074_Chip-Seq_NSC_Mouse1.15577094
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13833170
82SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12029669
83EST1_17652178_ChIP-ChIP_JURKAT_Human1.10760005
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.09720022
85FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08862627
86SOX9_26525672_Chip-Seq_HEART_Mouse1.08424339
87EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08095689
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.06273860
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06149766
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06149766
91REST_21632747_ChIP-Seq_MESCs_Mouse1.05739607
92TCF4_22108803_ChIP-Seq_LS180_Human1.05156009
93STAT3_18555785_Chip-Seq_ESCs_Mouse1.03929177
94SOX2_16153702_ChIP-ChIP_HESCs_Human1.02932542
95CRX_20693478_ChIP-Seq_RETINA_Mouse1.01535885
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01437804
97P300_18555785_Chip-Seq_ESCs_Mouse1.01185072
98SALL4_22934838_ChIP-ChIP_CD34+_Human1.00897839
99FLI1_21867929_ChIP-Seq_TH2_Mouse0.99772119
100OCT4_18555785_Chip-Seq_ESCs_Mouse0.97661422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.92963339
2MP0003880_abnormal_central_pattern3.21550101
3MP0001529_abnormal_vocalization2.62811722
4MP0001984_abnormal_olfaction2.62617700
5MP0000569_abnormal_digit_pigmentation2.55799607
6MP0009046_muscle_twitch2.52918622
7MP0001188_hyperpigmentation2.46075376
8MP0005551_abnormal_eye_electrophysiolog2.41898148
9MP0006276_abnormal_autonomic_nervous2.10078722
10MP0002234_abnormal_pharynx_morphology2.09412831
11MP0000383_abnormal_hair_follicle2.07918496
12MP0001486_abnormal_startle_reflex2.04613226
13MP0000778_abnormal_nervous_system2.01448252
14MP0002751_abnormal_autonomic_nervous1.92402890
15MP0000751_myopathy1.90078894
16MP0005253_abnormal_eye_physiology1.89222082
17MP0005423_abnormal_somatic_nervous1.85988358
18MP0002272_abnormal_nervous_system1.82108978
19MP0000427_abnormal_hair_cycle1.80249968
20MP0004270_analgesia1.76309368
21MP0009745_abnormal_behavioral_response1.70497532
22MP0008877_abnormal_DNA_methylation1.69422501
23MP0003121_genomic_imprinting1.57067660
24MP0006072_abnormal_retinal_apoptosis1.56338168
25MP0003787_abnormal_imprinting1.56099942
26MP0005248_abnormal_Harderian_gland1.49607692
27MP0008058_abnormal_DNA_repair1.49303045
28MP0002064_seizures1.48340080
29MP0003635_abnormal_synaptic_transmissio1.46395455
30MP0004145_abnormal_muscle_electrophysio1.42218393
31MP0005171_absent_coat_pigmentation1.41648917
32MP0002067_abnormal_sensory_capabilities1.41423844
33MP0010094_abnormal_chromosome_stability1.38928281
34MP0005645_abnormal_hypothalamus_physiol1.38838902
35MP0003122_maternal_imprinting1.38808592
36MP0002572_abnormal_emotion/affect_behav1.38741439
37MP0005386_behavior/neurological_phenoty1.34497483
38MP0004924_abnormal_behavior1.34497483
39MP0008007_abnormal_cellular_replicative1.34319684
40MP0000647_abnormal_sebaceous_gland1.28996461
41MP0003890_abnormal_embryonic-extraembry1.28726247
42MP0000372_irregular_coat_pigmentation1.28679682
43MP0000749_muscle_degeneration1.27019324
44MP0002734_abnormal_mechanical_nocicepti1.26855890
45MP0004215_abnormal_myocardial_fiber1.25886469
46MP0008057_abnormal_DNA_replication1.24045022
47MP0002063_abnormal_learning/memory/cond1.23033767
48MP0001501_abnormal_sleep_pattern1.22915840
49MP0004142_abnormal_muscle_tone1.22112102
50MP0004859_abnormal_synaptic_plasticity1.20734753
51MP0002184_abnormal_innervation1.19398960
52MP0010678_abnormal_skin_adnexa1.18160894
53MP0002282_abnormal_trachea_morphology1.17658224
54MP0003283_abnormal_digestive_organ1.16100812
55MP0002557_abnormal_social/conspecific_i1.15873279
56MP0004811_abnormal_neuron_physiology1.15387094
57MP0002882_abnormal_neuron_morphology1.14374915
58MP0001293_anophthalmia1.13870974
59MP0000955_abnormal_spinal_cord1.13332788
60MP0005646_abnormal_pituitary_gland1.11928424
61MP0006035_abnormal_mitochondrial_morpho1.11473140
62MP0003937_abnormal_limbs/digits/tail_de1.11022053
63MP0000566_synostosis1.10709796
64MP0002752_abnormal_somatic_nervous1.09937767
65MP0003950_abnormal_plasma_membrane1.09509848
66MP0006292_abnormal_olfactory_placode1.08182513
67MP0002090_abnormal_vision1.07388058
68MP0002332_abnormal_exercise_endurance1.06356043
69MP0002233_abnormal_nose_morphology1.05812027
70MP0002638_abnormal_pupillary_reflex1.05425915
71MP0002229_neurodegeneration1.05396780
72MP0005187_abnormal_penis_morphology1.05293281
73MP0003718_maternal_effect1.05203935
74MP0005394_taste/olfaction_phenotype1.03706164
75MP0005499_abnormal_olfactory_system1.03706164
76MP0005195_abnormal_posterior_eye1.00297519
77MP0000358_abnormal_cell_content/0.99856848
78MP0000631_abnormal_neuroendocrine_gland0.98141236
79MP0005391_vision/eye_phenotype0.97802572
80MP0001299_abnormal_eye_distance/0.95679690
81MP0001929_abnormal_gametogenesis0.95144117
82MP0002938_white_spotting0.89556867
83MP0008569_lethality_at_weaning0.89535285
84MP0002822_catalepsy0.89307184
85MP0003221_abnormal_cardiomyocyte_apopto0.88938643
86MP0001986_abnormal_taste_sensitivity0.88091650
87MP0003755_abnormal_palate_morphology0.87331878
88MP0001324_abnormal_eye_pigmentation0.86764121
89MP0003698_abnormal_male_reproductive0.85207105
90MP0001177_atelectasis0.83447196
91MP0002735_abnormal_chemical_nociception0.83336193
92MP0003935_abnormal_craniofacial_develop0.82379003
93MP0003077_abnormal_cell_cycle0.78739113
94MP0002152_abnormal_brain_morphology0.78276005
95MP0001968_abnormal_touch/_nociception0.77637255
96MP0001286_abnormal_eye_development0.75699287
97MP0002066_abnormal_motor_capabilities/c0.74348651
98MP0001661_extended_life_span0.74145343
99MP0009703_decreased_birth_body0.72248467
100MP0003631_nervous_system_phenotype0.71281592

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)4.91832870
2Hypothermia (HP:0002045)3.89094953
3Cortical dysplasia (HP:0002539)3.56117525
4Limb dystonia (HP:0002451)3.46732102
5Medial flaring of the eyebrow (HP:0010747)3.38639838
6Volvulus (HP:0002580)3.30096820
7Gait imbalance (HP:0002141)3.18267422
8Abnormality of the labia minora (HP:0012880)3.10281900
9Congenital primary aphakia (HP:0007707)3.05162293
10Abnormal hair whorl (HP:0010721)3.04009027
11Astrocytoma (HP:0009592)2.93428358
12Abnormality of the astrocytes (HP:0100707)2.93428358
13Aqueductal stenosis (HP:0002410)2.86898133
14Genital tract atresia (HP:0001827)2.86210798
15Pheochromocytoma (HP:0002666)2.85216173
16Ependymoma (HP:0002888)2.78430562
17Focal motor seizures (HP:0011153)2.73552308
18Atonic seizures (HP:0010819)2.72328419
19Vaginal atresia (HP:0000148)2.61548850
20Nephrogenic diabetes insipidus (HP:0009806)2.60344431
21Optic nerve hypoplasia (HP:0000609)2.53541481
22Rhabdomyosarcoma (HP:0002859)2.47560807
23Tubulointerstitial nephritis (HP:0001970)2.45123452
24Type II lissencephaly (HP:0007260)2.43085771
25Intestinal atresia (HP:0011100)2.41453144
26Degeneration of anterior horn cells (HP:0002398)2.38811103
27Abnormality of the anterior horn cell (HP:0006802)2.38811103
28Drooling (HP:0002307)2.36091249
29Pancreatic cysts (HP:0001737)2.35037673
30Progressive inability to walk (HP:0002505)2.34298782
31Febrile seizures (HP:0002373)2.31691724
32Renal cortical cysts (HP:0000803)2.29213736
33Oligodactyly (hands) (HP:0001180)2.26976797
34Colon cancer (HP:0003003)2.24979167
35Glioma (HP:0009733)2.24972603
36Pancreatic fibrosis (HP:0100732)2.23754104
37Poor coordination (HP:0002370)2.20903051
38Agnosia (HP:0010524)2.20683552
39Specific learning disability (HP:0001328)2.20482923
40Postaxial hand polydactyly (HP:0001162)2.18310607
41Gaze-evoked nystagmus (HP:0000640)2.16229526
42Neoplasm of the small intestine (HP:0100833)2.16227349
43Labial hypoplasia (HP:0000066)2.14456557
44Papillary thyroid carcinoma (HP:0002895)2.14426828
45Focal seizures (HP:0007359)2.11462699
46Neuroendocrine neoplasm (HP:0100634)2.11216396
47Decreased muscle mass (HP:0003199)2.11111279
48Excessive salivation (HP:0003781)2.08916170
49Hypoplastic female external genitalia (HP:0012815)2.07746046
50Biliary tract neoplasm (HP:0100574)2.07056826
51Lissencephaly (HP:0001339)2.04551123
52Urinary urgency (HP:0000012)2.03868635
53Scanning speech (HP:0002168)2.03844455
54Bifid tongue (HP:0010297)2.03782811
55Degeneration of the lateral corticospinal tracts (HP:0002314)2.01853815
56Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01853815
57Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.00190249
58Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.99479447
59Atrophy/Degeneration involving motor neurons (HP:0007373)1.98985023
60Tubulointerstitial abnormality (HP:0001969)1.98370951
61Increased hepatocellular lipid droplets (HP:0006565)1.98307777
62Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98004135
63Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96616360
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96616360
65Micropenis (HP:0000054)1.96563523
66Medulloblastoma (HP:0002885)1.95945146
67Steppage gait (HP:0003376)1.94887611
68Spastic tetraplegia (HP:0002510)1.94855035
69Retinal dysplasia (HP:0007973)1.94039839
70Decreased testicular size (HP:0008734)1.94029406
71Failure to thrive in infancy (HP:0001531)1.92850520
72Aplasia/Hypoplasia of the tongue (HP:0010295)1.89452294
73Birth length less than 3rd percentile (HP:0003561)1.89175031
74Astigmatism (HP:0000483)1.88995769
75Molar tooth sign on MRI (HP:0002419)1.86271370
76Abnormality of midbrain morphology (HP:0002418)1.86271370
77Chronic hepatic failure (HP:0100626)1.85878967
78Amblyopia (HP:0000646)1.85438519
79Growth hormone deficiency (HP:0000824)1.84710076
80Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84442296
81Hypoplasia of the brainstem (HP:0002365)1.84442296
82Abnormality of the renal cortex (HP:0011035)1.83910927
83Posterior subcapsular cataract (HP:0007787)1.83047359
84Abnormality of the corticospinal tract (HP:0002492)1.83011053
85Oligodactyly (HP:0012165)1.82951940
86Dysdiadochokinesis (HP:0002075)1.82763024
87Cerebellar dysplasia (HP:0007033)1.82376999
88Nephroblastoma (Wilms tumor) (HP:0002667)1.82325307
89Abnormality of chromosome stability (HP:0003220)1.82067127
90Anophthalmia (HP:0000528)1.81630370
91Postaxial foot polydactyly (HP:0001830)1.81523746
92Embryonal renal neoplasm (HP:0011794)1.80626330
93Abnormal gallbladder physiology (HP:0012438)1.79768741
94Cholecystitis (HP:0001082)1.79768741
95Abnormality of the musculature of the pelvis (HP:0001469)1.79594591
96Abnormality of the hip-girdle musculature (HP:0001445)1.79594591
97Dialeptic seizures (HP:0011146)1.78642282
98Neoplasm of the colon (HP:0100273)1.76353500
99Inability to walk (HP:0002540)1.74891455
100Small intestinal stenosis (HP:0012848)1.72403483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.87683545
2PDK23.55621987
3WNK33.40318305
4BMPR1B2.93362132
5MAP3K42.74431548
6EIF2AK32.69486145
7BUB12.59571506
8NEK12.52329585
9BCR2.46344754
10FRK2.43906591
11MARK12.40976544
12ERBB32.28095625
13TRIM281.96763593
14MKNK21.93664634
15STK391.66374933
16MAPK131.47067566
17OXSR11.44118581
18TSSK61.41282641
19SRPK11.40803420
20GRK71.38491256
21TNIK1.35543707
22PLK31.33521901
23CSNK1G21.31982969
24CASK1.21042798
25MINK11.21009404
26BRSK21.20867958
27MAP3K121.18839532
28PLK21.16744150
29CSNK1A1L1.15849043
30PAK31.14263694
31CSNK1G11.13423152
32CSNK1G31.12530384
33CDK191.11731002
34OBSCN1.09129477
35ADRBK21.08692586
36PLK41.07280318
37MKNK11.05956597
38MAP2K71.04345774
39BRSK11.03622578
40FGFR21.00731105
41BRD41.00484481
42CDC71.00340088
43PINK10.98780192
44NEK60.93733154
45DYRK30.91648570
46DYRK1A0.91511653
47EIF2AK10.91161833
48FER0.90520847
49ACVR1B0.90518981
50AKT30.88246848
51STK38L0.87480579
52NUAK10.86515712
53TGFBR10.84448534
54PRKCE0.83965876
55RPS6KA40.80730435
56NTRK20.79912854
57CAMKK20.75329793
58CAMK2A0.75301815
59TTK0.75197443
60PIK3CA0.70645479
61PLK10.70410630
62MAP2K40.70180286
63EPHA40.68467747
64CDK80.63541860
65SIK30.62149405
66KSR10.59829291
67MAP3K50.58136621
68NTRK30.58096893
69VRK10.57216626
70CDK180.52978094
71ATR0.52438100
72DYRK20.51475577
73EIF2AK20.50989540
74PRKCG0.49381201
75CDK140.48886551
76STK160.48413096
77NEK20.46987459
78CDK50.46643483
79GRK10.44375487
80ATM0.42977812
81CDK150.41760406
82PRKACB0.41370060
83ZAK0.41303478
84PAK60.40339828
85FGFR10.37696404
86SGK20.37689061
87WEE10.34634816
88UHMK10.33414147
89PIK3CG0.33115014
90MELK0.32998390
91CDK11A0.32376079
92MUSK0.32046965
93CSNK1D0.30684232
94PRKCZ0.30634184
95RPS6KA50.29112153
96SIK20.27341052
97WNK40.26845090
98CSNK1A10.26324508
99AURKB0.25942000
100PKN10.25740884

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.44567881
2Protein export_Homo sapiens_hsa030603.04681007
3Nicotine addiction_Homo sapiens_hsa050333.00318722
4Taste transduction_Homo sapiens_hsa047422.43618395
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.21503009
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.20819807
7GABAergic synapse_Homo sapiens_hsa047272.09609204
8Non-homologous end-joining_Homo sapiens_hsa034502.00341008
9Propanoate metabolism_Homo sapiens_hsa006401.89676277
10Fanconi anemia pathway_Homo sapiens_hsa034601.88179873
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81073520
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.79829822
13Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68102395
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66470395
15Basal transcription factors_Homo sapiens_hsa030221.64822876
16Circadian rhythm_Homo sapiens_hsa047101.64345267
17Oocyte meiosis_Homo sapiens_hsa041141.50981990
18Mismatch repair_Homo sapiens_hsa034301.49629020
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47816467
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.47557521
21Morphine addiction_Homo sapiens_hsa050321.44293810
22RNA degradation_Homo sapiens_hsa030181.43584493
23Cocaine addiction_Homo sapiens_hsa050301.38236127
24Steroid biosynthesis_Homo sapiens_hsa001001.37308111
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34976686
26Oxidative phosphorylation_Homo sapiens_hsa001901.29332533
27Regulation of autophagy_Homo sapiens_hsa041401.29181538
28Dopaminergic synapse_Homo sapiens_hsa047281.27952942
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25067874
30Glutamatergic synapse_Homo sapiens_hsa047241.20353874
31Synaptic vesicle cycle_Homo sapiens_hsa047211.14923632
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14522062
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12336783
34Amphetamine addiction_Homo sapiens_hsa050311.10385062
35Parkinsons disease_Homo sapiens_hsa050121.07649303
36Circadian entrainment_Homo sapiens_hsa047131.06932153
37Alcoholism_Homo sapiens_hsa050341.02286046
38Olfactory transduction_Homo sapiens_hsa047401.01090850
39Selenocompound metabolism_Homo sapiens_hsa004500.99614641
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98386187
41One carbon pool by folate_Homo sapiens_hsa006700.98193369
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98107022
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97738872
44Fatty acid elongation_Homo sapiens_hsa000620.96910502
45Cardiac muscle contraction_Homo sapiens_hsa042600.95559345
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94054429
47Cell cycle_Homo sapiens_hsa041100.93927826
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92577777
49Caffeine metabolism_Homo sapiens_hsa002320.91836887
50Butanoate metabolism_Homo sapiens_hsa006500.90666829
51Fatty acid biosynthesis_Homo sapiens_hsa000610.89669324
52Peroxisome_Homo sapiens_hsa041460.87606231
53Collecting duct acid secretion_Homo sapiens_hsa049660.85744331
54Axon guidance_Homo sapiens_hsa043600.85560638
55Serotonergic synapse_Homo sapiens_hsa047260.85051046
56Histidine metabolism_Homo sapiens_hsa003400.84821349
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84791282
58RNA polymerase_Homo sapiens_hsa030200.81809892
59Hedgehog signaling pathway_Homo sapiens_hsa043400.80360056
60Pyruvate metabolism_Homo sapiens_hsa006200.80035364
61Gap junction_Homo sapiens_hsa045400.79264858
62Vibrio cholerae infection_Homo sapiens_hsa051100.77628340
63Nitrogen metabolism_Homo sapiens_hsa009100.75372684
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74719970
65Salivary secretion_Homo sapiens_hsa049700.71880268
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71853898
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71838248
68RNA transport_Homo sapiens_hsa030130.68683105
69Renin-angiotensin system_Homo sapiens_hsa046140.67311842
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66322139
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66110562
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64785844
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.63420034
74Carbon metabolism_Homo sapiens_hsa012000.63124302
75Lysine degradation_Homo sapiens_hsa003100.60672273
76Proteasome_Homo sapiens_hsa030500.60320720
77Tryptophan metabolism_Homo sapiens_hsa003800.58392457
78Alzheimers disease_Homo sapiens_hsa050100.58243566
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57599150
80Huntingtons disease_Homo sapiens_hsa050160.57409352
81TGF-beta signaling pathway_Homo sapiens_hsa043500.56507915
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55744330
83Nucleotide excision repair_Homo sapiens_hsa034200.54698671
84beta-Alanine metabolism_Homo sapiens_hsa004100.53961355
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52626697
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.51004408
87Homologous recombination_Homo sapiens_hsa034400.50736094
88p53 signaling pathway_Homo sapiens_hsa041150.48808065
89Purine metabolism_Homo sapiens_hsa002300.48257047
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46955339
91Cholinergic synapse_Homo sapiens_hsa047250.46483568
92Hippo signaling pathway_Homo sapiens_hsa043900.46079919
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45759186
94Arginine and proline metabolism_Homo sapiens_hsa003300.43973028
95Calcium signaling pathway_Homo sapiens_hsa040200.43708249
96mRNA surveillance pathway_Homo sapiens_hsa030150.42888812
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42462268
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40679336
99cAMP signaling pathway_Homo sapiens_hsa040240.39435709
100Tyrosine metabolism_Homo sapiens_hsa003500.37478135

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