TAS1R3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a G-protein coupled receptor involved in taste responses. The encoded protein can form a heterodimeric receptor with TAS1R1 to elicit the umami taste response, or it can bind with TAS1R2 to form a receptor for the sweet taste response. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)8.87908355
2daunorubicin metabolic process (GO:0044597)8.87908355
3polyketide metabolic process (GO:0030638)8.87908355
4GDP-mannose metabolic process (GO:0019673)8.35150507
5cellular response to ATP (GO:0071318)8.11777430
6adenosine receptor signaling pathway (GO:0001973)7.44084062
7negative regulation of cell aging (GO:0090344)6.74343601
8regulation of skeletal muscle contraction (GO:0014819)6.47201189
9meiotic chromosome segregation (GO:0045132)6.20969967
10positive regulation of protein kinase C signaling (GO:0090037)6.12120469
11purinergic nucleotide receptor signaling pathway (GO:0035590)6.09522291
12adenine nucleotide transport (GO:0051503)5.63079347
13positive regulation of type I interferon-mediated signaling pathway (GO:0060340)5.44193401
14purine ribonucleotide transport (GO:0015868)5.40382165
15rRNA methylation (GO:0031167)5.32881359
16aminoglycoside antibiotic metabolic process (GO:0030647)5.29922701
17negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.15786318
18lens fiber cell differentiation (GO:0070306)5.11912484
19UV protection (GO:0009650)4.79278449
20purinergic receptor signaling pathway (GO:0035587)4.77722040
21regulation of interferon-beta biosynthetic process (GO:0045357)4.66278994
22response to ATP (GO:0033198)4.64786492
23G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.61239118
24peptidyl-glutamic acid carboxylation (GO:0017187)4.53445700
25protein carboxylation (GO:0018214)4.53445700
26mannose metabolic process (GO:0006013)4.44350061
27purine nucleotide transport (GO:0015865)4.43563065
28rRNA modification (GO:0000154)4.33215007
29mesenchymal cell differentiation involved in renal system development (GO:2001012)4.32787971
30mesenchymal cell differentiation involved in kidney development (GO:0072161)4.32787971
31detection of molecule of bacterial origin (GO:0032490)4.21497088
32histone H3-K4 trimethylation (GO:0080182)4.18754872
33negative regulation of interleukin-8 production (GO:0032717)4.18126485
34regulation of synapse structural plasticity (GO:0051823)4.16998341
35nucleoside transmembrane transport (GO:1901642)4.14287639
36histone phosphorylation (GO:0016572)4.12245590
37nucleotide transmembrane transport (GO:1901679)4.09345164
38melanin metabolic process (GO:0006582)4.06482032
39energy homeostasis (GO:0097009)4.05795313
40nucleotide-sugar biosynthetic process (GO:0009226)3.96694808
41snRNA transcription (GO:0009301)3.85101271
42melanin biosynthetic process (GO:0042438)3.63077666
43cellular anion homeostasis (GO:0030002)3.62567438
44presynaptic membrane assembly (GO:0097105)3.62333978
45regulation of cytokine production involved in inflammatory response (GO:1900015)3.58848980
46interferon-gamma production (GO:0032609)3.48746229
47mitotic cell cycle arrest (GO:0071850)3.48225337
48folic acid metabolic process (GO:0046655)3.46957669
49sex determination (GO:0007530)3.39311015
50CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.37603814
51* sensory perception of taste (GO:0050909)3.37268362
52sphingosine metabolic process (GO:0006670)3.37007092
53cellular response to virus (GO:0098586)3.36231876
54germinal center formation (GO:0002467)3.34848868
55ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.34548982
56nucleoside bisphosphate biosynthetic process (GO:0033866)3.34548982
57purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.34548982
58regulation of type I interferon-mediated signaling pathway (GO:0060338)3.34092471
59positive regulation of gamma-delta T cell activation (GO:0046645)3.32182177
60regulation of protein kinase A signaling (GO:0010738)3.29615219
61regulation of activation of Janus kinase activity (GO:0010533)3.28719201
62positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.27227357
63B cell receptor signaling pathway (GO:0050853)3.27157831
64sphingomyelin metabolic process (GO:0006684)3.26514832
65endocytic recycling (GO:0032456)3.23012359
66sulfate transmembrane transport (GO:1902358)3.18910719
67regulation of germinal center formation (GO:0002634)3.17662263
68granulocyte differentiation (GO:0030851)3.16864165
69regulation of cell aging (GO:0090342)3.15052094
70positive regulation of systemic arterial blood pressure (GO:0003084)3.11995378
71positive T cell selection (GO:0043368)3.11606214
72negative regulation of toll-like receptor signaling pathway (GO:0034122)3.10371555
73positive regulation of cellular amide metabolic process (GO:0034250)3.08563667
74positive thymic T cell selection (GO:0045059)3.07356992
75diol metabolic process (GO:0034311)3.07069365
76phosphatidylglycerol biosynthetic process (GO:0006655)3.06030037
77auditory receptor cell stereocilium organization (GO:0060088)3.06010674
78sialylation (GO:0097503)3.04335070
79detection of external biotic stimulus (GO:0098581)3.04239818
80nucleoside transport (GO:0015858)3.00889868
81DNA replication checkpoint (GO:0000076)3.00342397
82positive regulation of interferon-alpha production (GO:0032727)3.00307217
83positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.99269056
84tRNA modification (GO:0006400)2.98617390
85transepithelial transport (GO:0070633)2.98264865
86growth hormone receptor signaling pathway (GO:0060396)2.96280800
87DNA strand renaturation (GO:0000733)2.94416416
88prostate gland growth (GO:0060736)2.91000620
89gonadal mesoderm development (GO:0007506)2.90824758
90regulation of hydrogen peroxide metabolic process (GO:0010310)2.90651584
91negative regulation of mast cell activation (GO:0033004)2.87619018
92peristalsis (GO:0030432)2.86885960
93DNA duplex unwinding (GO:0032508)2.84413762
94purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.84145183
953-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.84145183
96positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.84087956
97regulation of translational fidelity (GO:0006450)2.83309057
98regulation of glucocorticoid metabolic process (GO:0031943)2.83136121
99negative regulation of erythrocyte differentiation (GO:0045647)2.80681269
100detection of biotic stimulus (GO:0009595)2.78667060
101glycoside metabolic process (GO:0016137)2.77088266
102mitochondrial genome maintenance (GO:0000002)2.75525739
103activation of JUN kinase activity (GO:0007257)2.74952756
104positive regulation of protein sumoylation (GO:0033235)2.74364269
105DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.74185745
106mRNA cleavage (GO:0006379)2.73271576
107cell differentiation involved in kidney development (GO:0061005)2.73229004
108NIK/NF-kappaB signaling (GO:0038061)2.72637998
109sulfate transport (GO:0008272)2.72524589
110regulation of interleukin-6 biosynthetic process (GO:0045408)2.71996280
111cardiolipin metabolic process (GO:0032048)2.71016311
112G-protein coupled receptor internalization (GO:0002031)2.69787490
113regulation of interferon-alpha production (GO:0032647)2.69692335
114positive regulation of heat generation (GO:0031652)2.68221022
115negative T cell selection (GO:0043383)2.67955654
116cell differentiation involved in metanephros development (GO:0072202)2.67891142
117regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.66025916
118ceramide catabolic process (GO:0046514)2.65913286
119histone H3-K9 modification (GO:0061647)2.65856666
120negative regulation of translation, ncRNA-mediated (GO:0040033)2.65394802
121regulation of translation, ncRNA-mediated (GO:0045974)2.65394802
122negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.65394802
123dentate gyrus development (GO:0021542)2.65214938
124opioid receptor signaling pathway (GO:0038003)2.64997976
125DNA geometric change (GO:0032392)2.64589041
126postsynaptic membrane organization (GO:0001941)2.64294293
127drinking behavior (GO:0042756)2.64274355
128grooming behavior (GO:0007625)2.63596918
129regulation of B cell receptor signaling pathway (GO:0050855)2.63471321
130regulation of chromatin binding (GO:0035561)2.61939423
131dendritic cell migration (GO:0036336)2.61616631
132proline biosynthetic process (GO:0006561)2.61064283
133negative thymic T cell selection (GO:0045060)2.60481885
134muscle atrophy (GO:0014889)2.59176031
135modulation by virus of host process (GO:0019054)2.58644139
136regulation of interleukin-8 secretion (GO:2000482)2.58463865
137negative regulation of tumor necrosis factor production (GO:0032720)2.57533566
138positive regulation of antigen processing and presentation (GO:0002579)2.56994633
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.56939412
140dendritic cell chemotaxis (GO:0002407)2.56452729
141regulation of interferon-beta production (GO:0032648)2.56363881
142positive regulation of blood pressure (GO:0045777)2.56334374
143presynaptic membrane organization (GO:0097090)2.55924930
144trivalent inorganic anion homeostasis (GO:0072506)2.55346664
145phosphate ion homeostasis (GO:0055062)2.55346664
146ganglion development (GO:0061548)2.54789797
147T cell selection (GO:0045058)2.54578571
148peptidyl-lysine trimethylation (GO:0018023)2.53027436
149secondary metabolite biosynthetic process (GO:0044550)2.52882882
150snRNA metabolic process (GO:0016073)2.52592501
151CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.50231810
152T-helper cell differentiation (GO:0042093)2.50231810
153modulation by symbiont of host cellular process (GO:0044068)2.49939736
154negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.49163653
155histone H3-K36 demethylation (GO:0070544)2.49093565
156regulation of interleukin-12 biosynthetic process (GO:0045075)2.48798141
157histone H3-K4 methylation (GO:0051568)2.47780277
158mitochondrion distribution (GO:0048311)2.46170810
159myeloid dendritic cell activation (GO:0001773)2.45705915
160regulation of dendritic cell antigen processing and presentation (GO:0002604)2.45339127
161macrophage activation (GO:0042116)2.45135573
162response to type I interferon (GO:0034340)2.44904024
163B cell homeostasis (GO:0001782)2.43509013
164negative regulation of phagocytosis (GO:0050765)2.42188091
165cellular response to type I interferon (GO:0071357)2.41826930
166type I interferon signaling pathway (GO:0060337)2.41826930
167cerebral cortex radially oriented cell migration (GO:0021799)2.41632972
168positive regulation of granulocyte differentiation (GO:0030854)2.41627965
169G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.41324197
170cellular response to growth hormone stimulus (GO:0071378)2.37995226
171positive regulation of protein homooligomerization (GO:0032464)2.36973576
172histone H3-K9 methylation (GO:0051567)2.36678477
173regulation of interleukin-1 beta secretion (GO:0050706)2.35908515
174regulation of memory T cell differentiation (GO:0043380)2.33541634
175positive regulation of interleukin-1 beta secretion (GO:0050718)2.31409138
176superoxide anion generation (GO:0042554)2.30156834
177inner ear receptor stereocilium organization (GO:0060122)2.29393990
178positive regulation of neurotransmitter secretion (GO:0001956)2.29367821
179pericardium development (GO:0060039)2.29063187
180behavioral response to pain (GO:0048266)2.28324146
181post-embryonic morphogenesis (GO:0009886)2.26812302
182thymic T cell selection (GO:0045061)2.25995377
183CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.24632932
184urinary tract smooth muscle contraction (GO:0014848)2.24531757
185striated muscle atrophy (GO:0014891)2.24033968
186regulation of gamma-delta T cell activation (GO:0046643)2.23813091
187positive regulation of uterine smooth muscle contraction (GO:0070474)2.23012483
188mesenchymal cell differentiation (GO:0048762)2.22906661

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human4.47751299
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.82629793
3MYC_22102868_ChIP-Seq_BL_Human3.41253990
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.35298908
5GBX2_23144817_ChIP-Seq_PC3_Human3.26187838
6TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.18534288
7LXR_22292898_ChIP-Seq_THP-1_Human3.06563298
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.74934334
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.74917024
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.66254714
11* P68_20966046_ChIP-Seq_HELA_Human2.55789311
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.50546511
13GATA1_22025678_ChIP-Seq_K562_Human2.46044470
14* MAF_26560356_Chip-Seq_TH2_Human2.43901331
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.37654373
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.37222129
17RACK7_27058665_Chip-Seq_MCF-7_Human2.36932128
18VDR_24763502_ChIP-Seq_THP-1_Human2.32005184
19MAF_26560356_Chip-Seq_TH1_Human2.29951646
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.28059501
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.27842539
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.26269520
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.19953941
24SUZ12_27294783_Chip-Seq_NPCs_Mouse2.17066131
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15651994
26KDM2B_26808549_Chip-Seq_DND41_Human2.13131590
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11588823
28BCOR_27268052_Chip-Seq_Bcells_Human2.08235710
29NFE2_27457419_Chip-Seq_LIVER_Mouse2.08175054
30BCL6_27268052_Chip-Seq_Bcells_Human2.05455680
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.04995549
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.00770621
33XRN2_22483619_ChIP-Seq_HELA_Human1.99820901
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98576866
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.97449047
36CTCF_27219007_Chip-Seq_ERYTHROID_Human1.97135984
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.92928696
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.92833098
39* TCF7_22412390_ChIP-Seq_EML_Mouse1.90790865
40EZH2_22144423_ChIP-Seq_EOC_Human1.90755558
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.87357177
42UTX_26944678_Chip-Seq_JUKART_Human1.85790533
43TET1_21451524_ChIP-Seq_MESCs_Mouse1.85246503
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.84392062
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.83128597
46* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.82517034
47E2F1_20622854_ChIP-Seq_HELA_Human1.82226859
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78923651
49EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.78641545
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76994441
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.75967830
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.75600999
53SMC4_20622854_ChIP-Seq_HELA_Human1.75296665
54* CTCF_27219007_Chip-Seq_Bcells_Human1.74553196
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.72765963
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.72113032
57P53_22387025_ChIP-Seq_ESCs_Mouse1.71419741
58SUZ12_18555785_Chip-Seq_ESCs_Mouse1.71262695
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.70167138
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.69294496
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69263559
62CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.68974978
63RARB_24833708_ChIP-Seq_LIVER_Mouse1.67424547
64* PHF8_20622854_ChIP-Seq_HELA_Human1.66468278
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64827482
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.64827482
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.63775667
68SCL_19346495_ChIP-Seq_HPC-7_Human1.63121520
69CTCF_21964334_Chip-Seq_Bcells_Human1.62435432
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62334347
71SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.61485351
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61079239
73EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.61025765
74RUNX_20019798_ChIP-Seq_JUKART_Human1.60535878
75STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.59729908
76VDR_24787735_ChIP-Seq_THP-1_Human1.59588397
77STAT3_18555785_Chip-Seq_ESCs_Mouse1.58038657
78RARA_24833708_ChIP-Seq_LIVER_Mouse1.58007428
79NMYC_18555785_Chip-Seq_ESCs_Mouse1.57275384
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.55923420
81IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55170953
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54989360
83P300_19829295_ChIP-Seq_ESCs_Human1.54679171
84CREB1_26743006_Chip-Seq_LNCaP_Human1.53805061
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52904539
86CMYC_18555785_Chip-Seq_ESCs_Mouse1.51265569
87IRF8_27001747_Chip-Seq_BMDM_Mouse1.50948476
88PU1_27457419_Chip-Seq_LIVER_Mouse1.50151063
89RUNX1_27457419_Chip-Seq_LIVER_Mouse1.49823092
90PU.1_20513432_ChIP-Seq_Bcells_Mouse1.47698921
91IRF8_21731497_ChIP-ChIP_J774_Mouse1.45866275
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45663185
93OCT4_18555785_Chip-Seq_ESCs_Mouse1.45322200
94CTCF_21964334_ChIP-Seq_BJAB-B_Human1.44344624
95FOXP1_21924763_ChIP-Seq_HESCs_Human1.43984100
96* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43890293
97* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42845695
98* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.40212178
99* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39963784
100SOX2_18555785_Chip-Seq_ESCs_Mouse1.39457796
101ZFX_18555785_Chip-Seq_ESCs_Mouse1.38644986
102P300_18555785_Chip-Seq_ESCs_Mouse1.37746249
103CIITA_25753668_ChIP-Seq_RAJI_Human1.36593356
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35745290
105DROSHA_22980978_ChIP-Seq_HELA_Human1.35553782
106* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34091538
107SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33878542
108FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33118168
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31761589
110* NCOR1_26117541_ChIP-Seq_K562_Human1.30005036
111CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29907165
112ETS1_21867929_ChIP-Seq_TH2_Mouse1.29512374
113TP53_22127205_ChIP-Seq_IMR90_Human1.29505408
114ESRRB_18555785_Chip-Seq_ESCs_Mouse1.28783140
115KDM2B_26808549_Chip-Seq_K562_Human1.28546065
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28083603
117KDM2B_26808549_Chip-Seq_JURKAT_Human1.28054302
118ATF3_27146783_Chip-Seq_COLON_Human1.27614167
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27600148
120SMAD4_21799915_ChIP-Seq_A2780_Human1.27079800
121GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26767666
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25479916
123MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25396238
124KLF4_18555785_Chip-Seq_ESCs_Mouse1.24881252
125SMAD3_21741376_ChIP-Seq_EPCs_Human1.24693255
126AR_25329375_ChIP-Seq_VCAP_Human1.24630238
127AR_21572438_ChIP-Seq_LNCaP_Human1.24360562
128OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23437163
129TCF4_18268006_ChIP-ChIP_LS174T_Human1.23125803
130CTCF_18555785_Chip-Seq_ESCs_Mouse1.22757465
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22399325
132* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22174304
133BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22126319
134RUNX1_22412390_ChIP-Seq_EML_Mouse1.21459394
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21123379
136* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20923654
137STAT3_23295773_ChIP-Seq_U87_Human1.20667334
138PIAS1_25552417_ChIP-Seq_VCAP_Human1.19796553
139FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19286046
140SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.18355552
141ER_23166858_ChIP-Seq_MCF-7_Human1.18313599
142RXR_22108803_ChIP-Seq_LS180_Human1.17551817
143SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17081372
144SMAD1_18555785_Chip-Seq_ESCs_Mouse1.17002487
145TP53_16413492_ChIP-PET_HCT116_Human1.15743509
146DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15658460
147* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15545225
148* SA1_27219007_Chip-Seq_Bcells_Human1.15069777
149TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13904059
150SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13853683
151CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12626786
152PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11627118
153CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10445487
154RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10128712
155TCF4_23295773_ChIP-Seq_U87_Human1.09855796
156* UBF1/2_26484160_Chip-Seq_HMECs_Human1.09647623
157CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09095853
158CRX_20693478_ChIP-Seq_RETINA_Mouse1.08759514
159RUNX1_27514584_Chip-Seq_MCF-7_Human1.08704440
160HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08486056
161NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08324520
162TAF15_26573619_Chip-Seq_HEK293_Human1.08094099
163CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08041397
164ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08002244
165RNF2_27304074_Chip-Seq_NSC_Mouse1.07988914
166CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07714778
167BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07639284
168JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.07341279
169YY1_22570637_ChIP-Seq_MALME-3M_Human1.07289307
170E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06963043
171P300_27268052_Chip-Seq_Bcells_Human1.06533713
172KDM2B_26808549_Chip-Seq_REH_Human1.06498465
173TP63_22573176_ChIP-Seq_HFKS_Human1.06279484
174NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06091905
175P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05960059
176SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05817299
177CTCF_20526341_ChIP-Seq_ESCs_Human1.05796129
178GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05261657
179NOTCH1_21737748_ChIP-Seq_TLL_Human1.05210428
180ESR2_21235772_ChIP-Seq_MCF-7_Human1.05092594
181BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04508892
182TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.04411989
183* CTCF_26484167_Chip-Seq_Bcells_Mouse1.04394956
184EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04377218
185EED_16625203_ChIP-ChIP_MESCs_Mouse1.04221763
186GATA2_21666600_ChIP-Seq_HMVEC_Human1.03628892
187MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02887999
188TP53_18474530_ChIP-ChIP_U2OS_Human1.01054210
189FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00772951
190MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00737868
191RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00003524
192PRDM14_20953172_ChIP-Seq_ESCs_Human0.99702470
193CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98743321
194JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98015746
195CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96877475
196SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96202583
197SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95006371
198ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93484347
199ARNT_22903824_ChIP-Seq_MCF-7_Human0.93480579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005174_abnormal_tail_pigmentation5.63103624
2MP0003136_yellow_coat_color5.09765676
3MP0005409_darkened_coat_color4.28442715
4MP0002138_abnormal_hepatobiliary_system3.34989686
5MP0005645_abnormal_hypothalamus_physiol3.23443447
6MP0008004_abnormal_stomach_pH3.20358693
7MP0004381_abnormal_hair_follicle2.90152822
8MP0005083_abnormal_biliary_tract2.84268258
9MP0005310_abnormal_salivary_gland2.80341602
10MP0003787_abnormal_imprinting2.68839955
11MP0000751_myopathy2.67022793
12MP0006292_abnormal_olfactory_placode2.66615464
13MP0001835_abnormal_antigen_presentation2.59563565
14MP0002277_abnormal_respiratory_mucosa2.46665275
15MP0005646_abnormal_pituitary_gland2.45199279
16MP0001790_abnormal_immune_system2.41224061
17MP0005387_immune_system_phenotype2.41224061
18MP0003705_abnormal_hypodermis_morpholog2.37433259
19MP0002254_reproductive_system_inflammat2.36752648
20MP0005671_abnormal_response_to2.29481121
21MP0003453_abnormal_keratinocyte_physiol2.27896260
22MP0003183_abnormal_peptide_metabolism2.26103609
23* MP0001986_abnormal_taste_sensitivity2.24595818
24MP0003303_peritoneal_inflammation2.23385842
25MP0005076_abnormal_cell_differentiation2.22944005
26MP0001661_extended_life_span2.21858795
27MP0005377_hearing/vestibular/ear_phenot2.19246988
28MP0003878_abnormal_ear_physiology2.19246988
29MP0009697_abnormal_copulation2.18167265
30MP0003111_abnormal_nucleus_morphology2.09054115
31MP0001968_abnormal_touch/_nociception2.07126706
32MP0002396_abnormal_hematopoietic_system2.01187429
33MP0001756_abnormal_urination2.00532469
34MP0002163_abnormal_gland_morphology1.99055046
35MP0001800_abnormal_humoral_immune1.97478171
36MP0002148_abnormal_hypersensitivity_rea1.97351235
37MP0003763_abnormal_thymus_physiology1.95680920
38MP0001346_abnormal_lacrimal_gland1.93073581
39MP0000685_abnormal_immune_system1.91298475
40MP0000013_abnormal_adipose_tissue1.90555373
41MP0004510_myositis1.87582312
42MP0002928_abnormal_bile_duct1.87301635
43MP0005379_endocrine/exocrine_gland_phen1.85240085
44MP0010386_abnormal_urinary_bladder1.83990448
45MP0004130_abnormal_muscle_cell1.82261171
46MP0002132_abnormal_respiratory_system1.81385441
47MP0000003_abnormal_adipose_tissue1.80587980
48MP0000750_abnormal_muscle_regeneration1.77457782
49MP0002419_abnormal_innate_immunity1.67097924
50MP0002723_abnormal_immune_serum1.67086993
51MP0000566_synostosis1.66917241
52MP0002452_abnormal_antigen_presenting1.66203846
53MP0002876_abnormal_thyroid_physiology1.60452265
54MP0001819_abnormal_immune_cell1.58340561
55MP0003941_abnormal_skin_development1.57870839
56MP0009785_altered_susceptibility_to1.56306023
57MP0002420_abnormal_adaptive_immunity1.55884470
58MP0004858_abnormal_nervous_system1.55280085
59MP0003724_increased_susceptibility_to1.54314998
60MP0004185_abnormal_adipocyte_glucose1.53757950
61MP0002006_tumorigenesis1.52906352
62MP0005000_abnormal_immune_tolerance1.50228811
63MP0001188_hyperpigmentation1.49586301
64MP0000747_muscle_weakness1.49142799
65MP0001873_stomach_inflammation1.46780622
66MP0005451_abnormal_body_composition1.41338271
67MP0005501_abnormal_skin_physiology1.40268396
68MP0003879_abnormal_hair_cell1.38443514
69MP0002166_altered_tumor_susceptibility1.37230835
70MP0003693_abnormal_embryo_hatching1.34276033
71MP0002735_abnormal_chemical_nociception1.33785726
72MP0005464_abnormal_platelet_physiology1.32752224
73MP0005025_abnormal_response_to1.31534256
74MP0000716_abnormal_immune_system1.27203546
75MP0005058_abnormal_lysosome_morphology1.26432340
76MP0002638_abnormal_pupillary_reflex1.24839161
77MP0002398_abnormal_bone_marrow1.24633738
78MP0003091_abnormal_cell_migration1.23712876
79MP0005330_cardiomyopathy1.23246207
80MP0002933_joint_inflammation1.18930375
81MP0004742_abnormal_vestibular_system1.15452394
82MP0002998_abnormal_bone_remodeling1.15340959
83MP0000569_abnormal_digit_pigmentation1.13711022
84MP0004808_abnormal_hematopoietic_stem1.13407747
85MP0006082_CNS_inflammation1.12287360
86MP0003077_abnormal_cell_cycle1.11281785
87MP0005375_adipose_tissue_phenotype1.11179167
88MP0001501_abnormal_sleep_pattern1.10526687
89MP0009278_abnormal_bone_marrow1.09214388
90MP0001764_abnormal_homeostasis1.08625842
91MP0002736_abnormal_nociception_after1.08175807
92MP0000678_abnormal_parathyroid_gland1.08046920
93MP0002019_abnormal_tumor_incidence1.06312163
94MP0005584_abnormal_enzyme/coenzyme_acti1.05949751
95MP0005647_abnormal_sex_gland1.04714599
96MP0005670_abnormal_white_adipose1.04206529
97MP0008995_early_reproductive_senescence1.02980140
98MP0009931_abnormal_skin_appearance1.02880268
99MP0009764_decreased_sensitivity_to1.02699449
100MP0000703_abnormal_thymus_morphology1.01225740
101MP0002095_abnormal_skin_pigmentation1.00995159
102MP0001984_abnormal_olfaction1.00200427
103MP0001545_abnormal_hematopoietic_system0.99207098
104MP0005397_hematopoietic_system_phenotyp0.99207098
105MP0001958_emphysema0.99086786
106* MP0005423_abnormal_somatic_nervous0.98281592
107MP0005666_abnormal_adipose_tissue0.98025891
108MP0005171_absent_coat_pigmentation0.96586065
109MP0002098_abnormal_vibrissa_morphology0.95541686
110MP0003436_decreased_susceptibility_to0.94389033
111MP0009840_abnormal_foam_cell0.94197909
112MP0000537_abnormal_urethra_morphology0.93953924
113MP0004957_abnormal_blastocyst_morpholog0.92756062
114MP0001502_abnormal_circadian_rhythm0.92295420
115MP0000383_abnormal_hair_follicle0.92235570
116MP0010094_abnormal_chromosome_stability0.91944122
117MP0003448_altered_tumor_morphology0.90310539
118MP0003045_fibrosis0.90005828
119MP0001845_abnormal_inflammatory_respons0.89624124
120MP0002429_abnormal_blood_cell0.89428757
121MP0003868_abnormal_feces_composition0.89235762
122MP0000681_abnormal_thyroid_gland0.88717529
123MP0002693_abnormal_pancreas_physiology0.88694268
124MP0002405_respiratory_system_inflammati0.88090833
125MP0005332_abnormal_amino_acid0.87885974
126MP0004947_skin_inflammation0.86902924
127MP0001348_abnormal_lacrimal_gland0.85601059
128MP0000613_abnormal_salivary_gland0.84873133
129MP0001765_abnormal_ion_homeostasis0.84472738
130MP0005220_abnormal_exocrine_pancreas0.84432547
131MP0002722_abnormal_immune_system0.83795506
132MP0008877_abnormal_DNA_methylation0.82809122
133MP0000538_abnormal_urinary_bladder0.82428656
134MP0000689_abnormal_spleen_morphology0.81960607
135MP0000367_abnormal_coat/_hair0.81633641
136MP0008875_abnormal_xenobiotic_pharmacok0.81063275
137MP0003828_pulmonary_edema0.80969889
138MP0004043_abnormal_pH_regulation0.80166056
139MP0002136_abnormal_kidney_physiology0.79832236
140MP0000470_abnormal_stomach_morphology0.79307972
141MP0005365_abnormal_bile_salt0.78372118
142MP0002009_preneoplasia0.77966078
143MP0010155_abnormal_intestine_physiology0.77821635
144MP0002075_abnormal_coat/hair_pigmentati0.77606005
145MP0005084_abnormal_gallbladder_morpholo0.77495090
146MP0001664_abnormal_digestion0.76857624
147MP0003866_abnormal_defecation0.74187629
148MP0000015_abnormal_ear_pigmentation0.73799823
149MP0004087_abnormal_muscle_fiber0.73751319
150MP0002557_abnormal_social/conspecific_i0.73726523
151MP0001186_pigmentation_phenotype0.72988328
152MP0003252_abnormal_bile_duct0.72681396
153MP0001486_abnormal_startle_reflex0.71426357
154MP0010771_integument_phenotype0.71193240
155MP0008469_abnormal_protein_level0.70745060
156MP0009643_abnormal_urine_homeostasis0.70121362
157MP0000759_abnormal_skeletal_muscle0.69504923
158MP0009333_abnormal_splenocyte_physiolog0.69247051
159MP0001216_abnormal_epidermal_layer0.65342027
160MP0003172_abnormal_lysosome_physiology0.65298605
161MP0003806_abnormal_nucleotide_metabolis0.65088283
162MP0004233_abnormal_muscle_weight0.57908665
163MP0008874_decreased_physiological_sensi0.57049715
164MP0000358_abnormal_cell_content/0.54974401
165MP0000313_abnormal_cell_death0.53330557

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)6.00073483
2Thin bony cortex (HP:0002753)5.79576178
3Rib fusion (HP:0000902)5.67998697
4Poikiloderma (HP:0001029)5.51146217
5Ulnar bowing (HP:0003031)5.10665527
6Intestinal fistula (HP:0100819)4.99658613
7Rectovaginal fistula (HP:0000143)4.92484838
8Rectal fistula (HP:0100590)4.92484838
9Annular pancreas (HP:0001734)4.76214969
10Facial hemangioma (HP:0000329)4.71882475
11Vaginal fistula (HP:0004320)4.68547731
12Turricephaly (HP:0000262)4.54951550
13Popliteal pterygium (HP:0009756)4.26598698
14Dyschromatopsia (HP:0007641)4.22506413
15Attenuation of retinal blood vessels (HP:0007843)4.06273483
16Unilateral renal agenesis (HP:0000122)4.00878926
17Squamous cell carcinoma (HP:0002860)3.99192089
18Abnormality of the intrinsic pathway (HP:0010989)3.92749066
19Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.92297868
20Akinesia (HP:0002304)3.82404628
21Hemorrhage of the eye (HP:0011885)3.75992302
22Fetal akinesia sequence (HP:0001989)3.62453227
23Abnormal hair whorl (HP:0010721)3.57906534
24Delayed epiphyseal ossification (HP:0002663)3.55387082
25Anteriorly placed anus (HP:0001545)3.52752058
26Aplasia of the musculature (HP:0100854)3.48700741
27Chronic hepatic failure (HP:0100626)3.47145338
28Coronal craniosynostosis (HP:0004440)3.46885925
29Facial diplegia (HP:0001349)3.45825977
30Congenital stationary night blindness (HP:0007642)3.42406934
31Short chin (HP:0000331)3.36886631
32Chromsome breakage (HP:0040012)3.34481554
33Chromosomal breakage induced by crosslinking agents (HP:0003221)3.33321349
34Aplasia/Hypoplasia of the patella (HP:0006498)3.26439444
35Cheilitis (HP:0100825)3.22290669
36Alopecia of scalp (HP:0002293)3.19244740
37Patellar aplasia (HP:0006443)3.11494994
38Myopathic facies (HP:0002058)3.08097693
39Joint hemorrhage (HP:0005261)3.03830178
40Bony spicule pigmentary retinopathy (HP:0007737)3.03043780
41Abnormality of the costochondral junction (HP:0000919)3.02828929
42Ectropion (HP:0000656)2.99453463
43Distal lower limb muscle weakness (HP:0009053)2.90464818
44Abnormality of the fingertips (HP:0001211)2.89197761
45Abnormality of placental membranes (HP:0011409)2.88369104
46Amniotic constriction ring (HP:0009775)2.88369104
47Capillary hemangiomas (HP:0005306)2.88194814
48Prostate neoplasm (HP:0100787)2.86925885
49Parakeratosis (HP:0001036)2.85368080
50Chorioretinal atrophy (HP:0000533)2.80834429
51Joint stiffness (HP:0001387)2.79823059
52Basal cell carcinoma (HP:0002671)2.76317227
53Absent eyelashes (HP:0000561)2.75629971
54Recurrent cutaneous fungal infections (HP:0011370)2.74572329
55Chronic mucocutaneous candidiasis (HP:0002728)2.74572329
56Retrobulbar optic neuritis (HP:0100654)2.70956619
57Optic neuritis (HP:0100653)2.70956619
58Thoracic kyphosis (HP:0002942)2.69878431
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.69644374
60Asymmetry of the thorax (HP:0001555)2.69631844
61Premature graying of hair (HP:0002216)2.68597058
62Enlarged epiphyses (HP:0010580)2.68591582
63Lip pit (HP:0100267)2.67101398
64Bowed forearm bones (HP:0003956)2.66093821
65Bowing of the arm (HP:0006488)2.66093821
66Widely patent fontanelles and sutures (HP:0004492)2.65890707
67Febrile seizures (HP:0002373)2.64277733
68Atrioventricular block (HP:0001678)2.59803829
69Follicular hyperkeratosis (HP:0007502)2.58639410
70Alveolar cell carcinoma (HP:0006519)2.57426603
71Male infertility (HP:0003251)2.57180642
72Fibular aplasia (HP:0002990)2.56422411
73Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.55143623
74Congenital sensorineural hearing impairment (HP:0008527)2.53409217
75Prolonged partial thromboplastin time (HP:0003645)2.52737673
76Thyroid-stimulating hormone excess (HP:0002925)2.52397665
77Flat occiput (HP:0005469)2.52029356
78Absent eyebrow (HP:0002223)2.49634582
79Hypoalbuminemia (HP:0003073)2.47466288
80Abnormal albumin level (HP:0012116)2.47466288
81Recurrent bacterial skin infections (HP:0005406)2.46484872
82Chronic diarrhea (HP:0002028)2.45572336
83Recurrent abscess formation (HP:0002722)2.44542483
84Recurrent fungal infections (HP:0002841)2.44384608
85Malignant hyperthermia (HP:0002047)2.43256198
86Dynein arm defect of respiratory motile cilia (HP:0012255)2.43147936
87Absent/shortened dynein arms (HP:0200106)2.43147936
88Abnormality of incisor morphology (HP:0011063)2.38795687
89Chronic otitis media (HP:0000389)2.38311665
90Absent thumb (HP:0009777)2.37664949
91Stomatitis (HP:0010280)2.37605542
92Osteomalacia (HP:0002749)2.36756298
93Increased number of teeth (HP:0011069)2.36485420
94Abnormal delayed hypersensitivity skin test (HP:0002963)2.35294959
95Neoplasm of the tracheobronchial system (HP:0100552)2.34775354
96Long clavicles (HP:0000890)2.33090321
97Agammaglobulinemia (HP:0004432)2.32995976
98Keratitis (HP:0000491)2.32959137
99Increased IgM level (HP:0003496)2.32926855
100Eczematoid dermatitis (HP:0000976)2.32783105
101Hypophosphatemic rickets (HP:0004912)2.32679430
102Birth length less than 3rd percentile (HP:0003561)2.32586341
103Conjugated hyperbilirubinemia (HP:0002908)2.32424106
104Ectopic kidney (HP:0000086)2.31496614
105Mesangial abnormality (HP:0001966)2.30481478
106Bilateral sensorineural hearing impairment (HP:0008619)2.29970270
107Clubbing of toes (HP:0100760)2.28398594
108Myositis (HP:0100614)2.27916669
109Thin ribs (HP:0000883)2.26679518
110Myotonia (HP:0002486)2.24305490
111Abnormality of small intestinal villus morphology (HP:0011472)2.22750087
112Villous atrophy (HP:0011473)2.22750087
113Narrow nasal bridge (HP:0000446)2.19185037
114Hypoplasia of the capital femoral epiphysis (HP:0003090)2.19032097
115Autoimmune thrombocytopenia (HP:0001973)2.18461362
116Arterial thrombosis (HP:0004420)2.17931789
117Choanal stenosis (HP:0000452)2.17558554
118Short humerus (HP:0005792)2.17221880
119Hyperphosphatemia (HP:0002905)2.16621956
120Colitis (HP:0002583)2.15551383
121Abnormality of dental color (HP:0011073)2.14345645
122Emphysema (HP:0002097)2.14165000
123Abnormality of the renal collecting system (HP:0004742)2.10262342
124Protruding tongue (HP:0010808)2.08483095
125Orchitis (HP:0100796)2.06948358
126Neoplasm of the lung (HP:0100526)2.06779582
127Bile duct proliferation (HP:0001408)2.06242778
128Abnormal biliary tract physiology (HP:0012439)2.06242778
129Lymphopenia (HP:0001888)2.04151918
130Abnormality of the thoracic spine (HP:0100711)2.03760721
131Choroideremia (HP:0001139)2.02595204
132Hyperventilation (HP:0002883)2.02325665
133Progressive muscle weakness (HP:0003323)2.01852080
134Breast hypoplasia (HP:0003187)2.00649292
135Progressive external ophthalmoplegia (HP:0000590)2.00399040
136Rectal prolapse (HP:0002035)1.99636833
137Easy fatigability (HP:0003388)1.97971733
138Natal tooth (HP:0000695)1.97662143
139Recurrent skin infections (HP:0001581)1.97383164
140Abnormality of DNA repair (HP:0003254)1.95630268
141Spina bifida occulta (HP:0003298)1.95031008
142Abnormality of cells of the lymphoid lineage (HP:0012140)1.94227745
143Abnormality of the prostate (HP:0008775)1.94025467
144Exercise-induced myalgia (HP:0003738)1.93893585
145Fair hair (HP:0002286)1.93660787
146Mitral stenosis (HP:0001718)1.92926524
147Neonatal onset (HP:0003623)1.91907785
148Gingival bleeding (HP:0000225)1.91514367
149Abnormal epiphyseal ossification (HP:0010656)1.90940063
150Reduced antithrombin III activity (HP:0001976)1.90243038
151Prolonged bleeding time (HP:0003010)1.90097719
152Pustule (HP:0200039)1.89831688
153Gastrointestinal infarctions (HP:0005244)1.89790439
154Meningitis (HP:0001287)1.87744246
155Fatigable weakness (HP:0003473)1.86999311
156Abnormality of the neuromuscular junction (HP:0003398)1.86999311
157Aplasia/hypoplasia of the humerus (HP:0006507)1.86893486
158Cranial hyperostosis (HP:0004437)1.86618632
159Decreased circulating renin level (HP:0003351)1.84691638
160Panhypogammaglobulinemia (HP:0003139)1.83811125
161Vasculitis (HP:0002633)1.83229305
162Pterygium (HP:0001059)1.81877440
163Hypoplasia of the pons (HP:0012110)1.81679706
164Cystic hygroma (HP:0000476)1.81566249
165Thickened calvaria (HP:0002684)1.81530992
166Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78139186
167Chronic sinusitis (HP:0011109)1.77652822
168Hypochromic anemia (HP:0001931)1.76493713
169Myocardial infarction (HP:0001658)1.76462483
170Neutropenia (HP:0001875)1.76400492
171Encephalitis (HP:0002383)1.75817830
172Neonatal respiratory distress (HP:0002643)1.74238513
173Recurrent viral infections (HP:0004429)1.74027147
174Craniofacial hyperostosis (HP:0004493)1.72882545
175Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72572200
176Generalized hypopigmentation of hair (HP:0011358)1.72287923
177Absent radius (HP:0003974)1.72123777
178Short thumb (HP:0009778)1.71867488
179Urethral obstruction (HP:0000796)1.71580618
180Abnormality of the common coagulation pathway (HP:0010990)1.71306251
181Mask-like facies (HP:0000298)1.70913717
182External ophthalmoplegia (HP:0000544)1.70822274
183Long foot (HP:0001833)1.70678622
184Lower limb amyotrophy (HP:0007210)1.70029612
185Keratoconjunctivitis (HP:0001096)1.69806805
186Neoplasm of the respiratory system (HP:0100606)1.68929412
187J-shaped sella turcica (HP:0002680)1.68345744
188Abnormality of the intervertebral disk (HP:0005108)1.67475644
189Hypoplasia of the thymus (HP:0000778)1.66686708
190Absent epiphyses (HP:0010577)1.65232615
191Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.65232615
192Myelodysplasia (HP:0002863)1.64575451
193Periodontitis (HP:0000704)1.64130669
194Urticaria (HP:0001025)1.63304972
195Thyroiditis (HP:0100646)1.63128828
196Recurrent pneumonia (HP:0006532)1.62576747

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.21306713
2BLK4.67639346
3ERN14.23588346
4TRIB34.11432695
5SIK33.65608830
6MAP3K143.13149279
7BMPR1B2.73460360
8WNK42.61817054
9CASK2.52009128
10TXK2.46125109
11MAP3K102.37383416
12PRPF4B2.36167418
13EEF2K2.29646800
14SGK22.22118665
15IRAK32.15226471
16TLK12.08258695
17LATS12.07270907
18INSRR2.03218097
19TAOK32.02958116
20SIK22.01656133
21GRK61.98708614
22ZAK1.91901142
23TESK21.84776903
24CCNB11.83190270
25TNIK1.78848236
26ADRBK21.76437182
27SIK11.74648122
28MAP4K11.67108470
29MST1R1.63469359
30CDK81.62971567
31SGK31.62645330
32JAK31.62285609
33PKN21.57636043
34ICK1.51270757
35IKBKB1.48473000
36TEC1.45613745
37IRAK41.44964278
38IRAK21.44646814
39BRD41.42666031
40SMG11.42643867
41MKNK21.42157631
42AKT31.41574868
43CHUK1.41266229
44YES11.39674121
45ERBB31.36793534
46MAP2K71.35226639
47IKBKE1.33583415
48EPHA21.29049891
49CDK41.28437778
50TNK21.28093905
51KIT1.21678667
52JAK11.20995038
53TAOK21.20734853
54SGK2231.20626636
55SGK4941.20626636
56PDPK11.17738464
57EPHA41.17403592
58TRPM71.17176112
59MARK31.12139137
60PRKD21.11697626
61CDK121.11076168
62NEK91.01163249
63TYK21.00350575
64STK38L0.99890307
65GRK70.98348148
66MAPK70.95801143
67NUAK10.95750617
68FRK0.94263669
69MAP3K60.93288399
70PRKD30.90646246
71EIF2AK20.88065913
72RPS6KA20.87381763
73MAP2K60.86764212
74STK390.85211219
75SYK0.84982996
76CDK30.84433032
77PIM20.83582771
78STK160.82751903
79DYRK1B0.82597922
80CSK0.82263152
81CDK90.82001436
82TTN0.81898963
83TBK10.79972470
84MTOR0.79207724
85ACVR1B0.78340523
86ZAP700.77239327
87DAPK20.76858399
88MAPK130.75806494
89TGFBR20.75252632
90RPS6KL10.75175435
91RPS6KC10.75175435
92WNK10.72773523
93ADRBK10.72350945
94MAP2K30.70360943
95NLK0.69384170
96RPS6KA60.69295064
97PRKD10.66046064
98FGFR40.66010618
99MAP3K110.64602041
100PRKAA20.63932499
101MAP3K120.63193877
102LCK0.62773511
103PKN10.62541987
104CDK60.61673673
105MST40.61623865
106PIK3CA0.60149518
107CDC42BPA0.59935871
108BTK0.59714091
109BMX0.59591517
110GRK50.59316860
111MELK0.58287836
112SGK10.58237041
113PDK10.57436145
114FGFR30.56301319
115HCK0.55904867
116NEK20.55656913
117TAOK10.55184839
118BMPR20.54885577
119PRKCQ0.53426432
120LYN0.53289209
121JAK20.52598456
122PIM10.52587595
123RIPK40.52401560
124MUSK0.50971552
125MAP3K30.50366314
126NTRK30.48835300
127ARAF0.48208385
128GRK10.47937802
129HIPK20.47618996
130STK110.46277864
131MAP2K20.45654197
132CAMK40.45219901
133PRKCH0.43984439
134MAP3K130.43679469
135OBSCN0.43563928
136LMTK20.42788766
137STK240.42525960
138EPHA30.42251956
139DYRK1A0.41384807
140MAP3K40.40744462
141PTK60.40340030
142CAMK1D0.40070976
143CSF1R0.40022982
144MAPK110.39157234
145MARK20.38376590
146MAPK80.37349517
147MKNK10.36236347
148MAP2K10.36118063
149ITK0.36065594
150NME20.35107938
151ABL10.35085431
152PRKAA10.34813677
153MAP3K70.34683884
154MAPK120.34264901
155PIK3CG0.33936244
156RPS6KA50.33021307
157ERBB40.32869884
158MAP3K10.31484661
159RIPK10.31469693
160ATR0.31323682
161RAF10.30599996
162AKT20.30295789
163BRAF0.29825202
164AURKA0.29214715

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006047.03533451
2Fructose and mannose metabolism_Homo sapiens_hsa000513.35785210
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.33544189
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.23722490
5Primary immunodeficiency_Homo sapiens_hsa053402.60192440
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.59566215
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.59144699
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.29565685
9Measles_Homo sapiens_hsa051622.28341832
10Allograft rejection_Homo sapiens_hsa053302.23814267
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.07683024
12Leishmaniasis_Homo sapiens_hsa051402.07479744
13Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.96272453
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.80519461
15Hematopoietic cell lineage_Homo sapiens_hsa046401.79378521
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.72587027
17Graft-versus-host disease_Homo sapiens_hsa053321.71211340
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69988524
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.59907957
20Type I diabetes mellitus_Homo sapiens_hsa049401.57816701
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.55631400
22Autoimmune thyroid disease_Homo sapiens_hsa053201.55576790
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54036885
24Osteoclast differentiation_Homo sapiens_hsa043801.47021568
25Influenza A_Homo sapiens_hsa051641.46643507
26Type II diabetes mellitus_Homo sapiens_hsa049301.38985306
27Lysine degradation_Homo sapiens_hsa003101.37715479
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.36913688
29Herpes simplex infection_Homo sapiens_hsa051681.36652823
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.36478011
31Circadian rhythm_Homo sapiens_hsa047101.30124181
32mTOR signaling pathway_Homo sapiens_hsa041501.30065336
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28942031
34Other glycan degradation_Homo sapiens_hsa005111.28921197
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27548202
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26187495
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26017810
38Rheumatoid arthritis_Homo sapiens_hsa053231.24516476
39Fanconi anemia pathway_Homo sapiens_hsa034601.24109457
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.23503192
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22813082
42Sphingolipid metabolism_Homo sapiens_hsa006001.21560559
43ABC transporters_Homo sapiens_hsa020101.20628210
44Bladder cancer_Homo sapiens_hsa052191.20253028
45TNF signaling pathway_Homo sapiens_hsa046681.19426489
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19139484
47Tuberculosis_Homo sapiens_hsa051521.17871695
48Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17578085
49Prolactin signaling pathway_Homo sapiens_hsa049171.14639131
50VEGF signaling pathway_Homo sapiens_hsa043701.10121062
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09476527
52Non-small cell lung cancer_Homo sapiens_hsa052231.08920424
53T cell receptor signaling pathway_Homo sapiens_hsa046601.07936415
54African trypanosomiasis_Homo sapiens_hsa051431.07391512
55Chemokine signaling pathway_Homo sapiens_hsa040621.05156368
56Vitamin digestion and absorption_Homo sapiens_hsa049771.04993474
57Pertussis_Homo sapiens_hsa051331.01363701
58Toxoplasmosis_Homo sapiens_hsa051451.00372627
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94136911
60Staphylococcus aureus infection_Homo sapiens_hsa051500.92614954
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90268120
62Hepatitis C_Homo sapiens_hsa051600.89517339
63Caffeine metabolism_Homo sapiens_hsa002320.88640159
64Hepatitis B_Homo sapiens_hsa051610.87783249
65Insulin resistance_Homo sapiens_hsa049310.87359379
66Chronic myeloid leukemia_Homo sapiens_hsa052200.87239302
67Base excision repair_Homo sapiens_hsa034100.85871446
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85498971
69Hedgehog signaling pathway_Homo sapiens_hsa043400.84309326
70* Taste transduction_Homo sapiens_hsa047420.83578792
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81650789
72Salmonella infection_Homo sapiens_hsa051320.79193680
73B cell receptor signaling pathway_Homo sapiens_hsa046620.77995628
74Alcoholism_Homo sapiens_hsa050340.76884874
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76244553
76Systemic lupus erythematosus_Homo sapiens_hsa053220.75797321
77Homologous recombination_Homo sapiens_hsa034400.75787181
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75755078
79Morphine addiction_Homo sapiens_hsa050320.73165958
80Serotonergic synapse_Homo sapiens_hsa047260.73088270
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73057093
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72349819
83Lysosome_Homo sapiens_hsa041420.72081605
84FoxO signaling pathway_Homo sapiens_hsa040680.72013921
85Legionellosis_Homo sapiens_hsa051340.68762785
86Apoptosis_Homo sapiens_hsa042100.68686074
87MAPK signaling pathway_Homo sapiens_hsa040100.67947873
88Acute myeloid leukemia_Homo sapiens_hsa052210.67748957
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.66006742
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.65371683
91Endometrial cancer_Homo sapiens_hsa052130.65085323
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64646735
93One carbon pool by folate_Homo sapiens_hsa006700.63815759
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.60659598
95Insulin signaling pathway_Homo sapiens_hsa049100.60295038
96Asthma_Homo sapiens_hsa053100.59869932
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58996618
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58320010
99Malaria_Homo sapiens_hsa051440.56645578
100Regulation of autophagy_Homo sapiens_hsa041400.56325090
101Sulfur relay system_Homo sapiens_hsa041220.55260774
102Ovarian steroidogenesis_Homo sapiens_hsa049130.55063536
103Nicotine addiction_Homo sapiens_hsa050330.54527562
104Pancreatic cancer_Homo sapiens_hsa052120.53475652
105Inositol phosphate metabolism_Homo sapiens_hsa005620.52001595
106Endocytosis_Homo sapiens_hsa041440.51887989
107Small cell lung cancer_Homo sapiens_hsa052220.49356081
108AMPK signaling pathway_Homo sapiens_hsa041520.48424825
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45919587
110Arachidonic acid metabolism_Homo sapiens_hsa005900.45462555
111Calcium signaling pathway_Homo sapiens_hsa040200.45337923
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.44546620
113Mineral absorption_Homo sapiens_hsa049780.44487504
114Viral carcinogenesis_Homo sapiens_hsa052030.43540647
115Notch signaling pathway_Homo sapiens_hsa043300.43200034
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.43148491
117Phagosome_Homo sapiens_hsa041450.42426566
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.41697875
119HTLV-I infection_Homo sapiens_hsa051660.40915433
120p53 signaling pathway_Homo sapiens_hsa041150.40718041
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40232296
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39830457
123ErbB signaling pathway_Homo sapiens_hsa040120.39544079
124Platelet activation_Homo sapiens_hsa046110.39166369
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38489507
126Arginine biosynthesis_Homo sapiens_hsa002200.38255084
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37994402
128Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37733595
129Dorso-ventral axis formation_Homo sapiens_hsa043200.36977379
130Prostate cancer_Homo sapiens_hsa052150.36707047
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36696398
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.36258267
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35375223
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35355469
135Melanogenesis_Homo sapiens_hsa049160.34307030
136Viral myocarditis_Homo sapiens_hsa054160.33917434
137Non-homologous end-joining_Homo sapiens_hsa034500.33763637
138Shigellosis_Homo sapiens_hsa051310.33196356
139Cell cycle_Homo sapiens_hsa041100.32996010
140Melanoma_Homo sapiens_hsa052180.32912347
141Biosynthesis of amino acids_Homo sapiens_hsa012300.32443397
142Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32427368
143Starch and sucrose metabolism_Homo sapiens_hsa005000.31528369
144Colorectal cancer_Homo sapiens_hsa052100.30197756
145Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28867833
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.27713360
147Epstein-Barr virus infection_Homo sapiens_hsa051690.26917440
148Pyrimidine metabolism_Homo sapiens_hsa002400.26859915

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