TARBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.59613604
2formation of translation preinitiation complex (GO:0001731)4.85113926
3DNA strand elongation involved in DNA replication (GO:0006271)4.62127770
4establishment of integrated proviral latency (GO:0075713)4.50070539
5DNA strand elongation (GO:0022616)4.37269944
6telomere maintenance via semi-conservative replication (GO:0032201)4.36339616
7DNA replication initiation (GO:0006270)4.06884357
8maturation of SSU-rRNA (GO:0030490)4.03503003
9nucleobase biosynthetic process (GO:0046112)4.00501551
10mitotic metaphase plate congression (GO:0007080)3.94434682
11establishment of viral latency (GO:0019043)3.92052817
12DNA replication checkpoint (GO:0000076)3.90941613
13purine nucleobase biosynthetic process (GO:0009113)3.85336759
14telomere maintenance via recombination (GO:0000722)3.80900452
15regulation of mitochondrial translation (GO:0070129)3.79958113
16protein localization to kinetochore (GO:0034501)3.76634639
17ribosome biogenesis (GO:0042254)3.74427219
18DNA unwinding involved in DNA replication (GO:0006268)3.71597985
19L-serine metabolic process (GO:0006563)3.63837857
20spliceosomal snRNP assembly (GO:0000387)3.63236278
21kinetochore assembly (GO:0051382)3.58402948
22mitotic nuclear envelope disassembly (GO:0007077)3.55174555
23protein localization to chromosome, centromeric region (GO:0071459)3.51350117
24pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.50402201
25mitotic recombination (GO:0006312)3.50098385
26ribonucleoprotein complex biogenesis (GO:0022613)3.50064834
27ribosomal large subunit biogenesis (GO:0042273)3.49093072
28peptidyl-arginine methylation (GO:0018216)3.48266932
29peptidyl-arginine N-methylation (GO:0035246)3.48266932
30nucleotide-excision repair, DNA gap filling (GO:0006297)3.46410548
31DNA replication-dependent nucleosome organization (GO:0034723)3.46146470
32DNA replication-dependent nucleosome assembly (GO:0006335)3.46146470
33telomere maintenance via telomere lengthening (GO:0010833)3.44551642
34translational initiation (GO:0006413)3.42469767
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.41626869
36viral transcription (GO:0019083)3.41383243
37kinetochore organization (GO:0051383)3.41174058
38somatic diversification of immune receptors via somatic mutation (GO:0002566)3.41044308
39somatic hypermutation of immunoglobulin genes (GO:0016446)3.41044308
40ribosomal small subunit assembly (GO:0000028)3.38394736
41translational termination (GO:0006415)3.36572736
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.36326973
43maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.35937687
44ribosome assembly (GO:0042255)3.35160395
45viral mRNA export from host cell nucleus (GO:0046784)3.33096543
46protein maturation by protein folding (GO:0022417)3.32895106
47rRNA processing (GO:0006364)3.31825807
48regulation of translational fidelity (GO:0006450)3.31066161
49DNA ligation (GO:0006266)3.30583970
50proteasome assembly (GO:0043248)3.29518308
51transcription from mitochondrial promoter (GO:0006390)3.29330484
52pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.29283598
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.28574787
54guanosine-containing compound biosynthetic process (GO:1901070)3.27705191
55heterochromatin organization (GO:0070828)3.27464670
56chaperone-mediated protein transport (GO:0072321)3.26916429
57translational elongation (GO:0006414)3.26303267
58UTP biosynthetic process (GO:0006228)3.26236805
59folic acid-containing compound biosynthetic process (GO:0009396)3.24915292
60nuclear envelope disassembly (GO:0051081)3.24835533
61membrane disassembly (GO:0030397)3.24835533
62pseudouridine synthesis (GO:0001522)3.24482255
63IMP biosynthetic process (GO:0006188)3.23810751
64metaphase plate congression (GO:0051310)3.23770943
65mitotic sister chromatid segregation (GO:0000070)3.23202357
66replication fork processing (GO:0031297)3.23177560
67rRNA metabolic process (GO:0016072)3.22647730
68tRNA aminoacylation for protein translation (GO:0006418)3.21492320
69pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.21454197
70negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.20023547
71proline biosynthetic process (GO:0006561)3.18830402
72base-excision repair (GO:0006284)3.18576393
73ribosomal small subunit biogenesis (GO:0042274)3.18483410
74negative regulation of mRNA processing (GO:0050686)3.18410957
75regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.17870368
76rRNA modification (GO:0000154)3.17753315
77establishment of protein localization to mitochondrial membrane (GO:0090151)3.16408803
78negative regulation of RNA splicing (GO:0033119)3.16306123
79regulation of double-strand break repair via homologous recombination (GO:0010569)3.14482865
80protein targeting to mitochondrion (GO:0006626)3.14218834
81mitotic chromosome condensation (GO:0007076)3.13730666
82tRNA aminoacylation (GO:0043039)3.13390784
83amino acid activation (GO:0043038)3.13390784
84CTP biosynthetic process (GO:0006241)3.13241686
85CTP metabolic process (GO:0046036)3.13241686
86positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.12939640
87DNA damage response, detection of DNA damage (GO:0042769)3.11862860
88transcription elongation from RNA polymerase III promoter (GO:0006385)3.11109428
89termination of RNA polymerase III transcription (GO:0006386)3.11109428
90chromatin remodeling at centromere (GO:0031055)3.09393927
91histone arginine methylation (GO:0034969)3.09322607
92mitochondrial DNA metabolic process (GO:0032042)3.08937902
93CENP-A containing nucleosome assembly (GO:0034080)3.06186339
94negative regulation of chromosome segregation (GO:0051985)3.06045646
95maturation of 5.8S rRNA (GO:0000460)3.05874780
96SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.05589786
97transcription-coupled nucleotide-excision repair (GO:0006283)3.04147719
98regulation of gene silencing by RNA (GO:0060966)3.03898136
99regulation of posttranscriptional gene silencing (GO:0060147)3.03898136
100regulation of gene silencing by miRNA (GO:0060964)3.03898136
101rRNA transcription (GO:0009303)3.03809175
102negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.03750114
103GTP biosynthetic process (GO:0006183)3.03256863
104nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02104065
105regulation of ubiquitin-protein transferase activity (GO:0051438)3.00500463
106peptidyl-histidine modification (GO:0018202)2.99517423
107cotranslational protein targeting to membrane (GO:0006613)2.98188740
108negative regulation of ligase activity (GO:0051352)2.97842673
109negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.97842673
110signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.97049020
111intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.97049020
112peptidyl-arginine omega-N-methylation (GO:0035247)2.97012289
113mitochondrial RNA metabolic process (GO:0000959)2.96975236
114signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.96044211
115signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.96044211
116signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.96044211
117termination of RNA polymerase II transcription (GO:0006369)2.95839036
118translation (GO:0006412)2.95677694
119signal transduction involved in DNA damage checkpoint (GO:0072422)2.95568376
120signal transduction involved in DNA integrity checkpoint (GO:0072401)2.95568376
121pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.95269322
122ATP synthesis coupled proton transport (GO:0015986)2.95132773
123energy coupled proton transport, down electrochemical gradient (GO:0015985)2.95132773
124DNA replication-independent nucleosome assembly (GO:0006336)2.94758690
125DNA replication-independent nucleosome organization (GO:0034724)2.94758690
126protein targeting to ER (GO:0045047)2.94091983
127folic acid metabolic process (GO:0046655)2.93986486
128regulation of cellular amino acid metabolic process (GO:0006521)2.93594519
129positive regulation of ligase activity (GO:0051351)2.93548148
130positive regulation of chromosome segregation (GO:0051984)2.90983727
131histone exchange (GO:0043486)2.90869216
132positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.88012428
133cullin deneddylation (GO:0010388)2.87586381
134protein complex localization (GO:0031503)2.86621456
135establishment of chromosome localization (GO:0051303)2.85932490
136negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85696279
137negative regulation of sister chromatid segregation (GO:0033046)2.85696279
138negative regulation of mitotic sister chromatid separation (GO:2000816)2.85696279
139negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85696279
140regulation of chromosome segregation (GO:0051983)2.84938896
141G1/S transition of mitotic cell cycle (GO:0000082)2.83933259
142cell cycle G1/S phase transition (GO:0044843)2.83933259
143DNA strand renaturation (GO:0000733)2.83357995
144regulation of centrosome cycle (GO:0046605)2.81921012
145regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.81561374
146regulation of spindle organization (GO:0090224)2.81152501
147IMP metabolic process (GO:0046040)2.79370570
148DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.79101857
149RNA splicing, via transesterification reactions (GO:0000375)2.78750530
150mRNA splicing, via spliceosome (GO:0000398)2.78635140

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.28206649
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.22666913
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72056116
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.32141508
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.05666340
6* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.98023273
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95605099
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.92799423
9* ETS1_20019798_ChIP-Seq_JURKAT_Human2.84482396
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.79908877
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.79829720
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.75554278
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69322754
14* EST1_17652178_ChIP-ChIP_JURKAT_Human2.64603048
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.60401741
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43434089
17* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31084875
18* XRN2_22483619_ChIP-Seq_HELA_Human2.30042771
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19994520
20* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10809913
21GABP_19822575_ChIP-Seq_HepG2_Human2.00933116
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00357991
23* VDR_23849224_ChIP-Seq_CD4+_Human1.95660947
24NANOG_18555785_ChIP-Seq_MESCs_Mouse1.93240157
25* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92767699
26DCP1A_22483619_ChIP-Seq_HELA_Human1.92216058
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88378192
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88227243
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.87731470
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87176903
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.81514615
32* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80741372
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78350772
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78038562
35TTF2_22483619_ChIP-Seq_HELA_Human1.73272153
36* FOXP3_21729870_ChIP-Seq_TREG_Human1.72243926
37CIITA_25753668_ChIP-Seq_RAJI_Human1.63639774
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59024318
39MYC_22102868_ChIP-Seq_BL_Human1.57086856
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.56949306
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55540493
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.55237633
43* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54381965
44AR_21909140_ChIP-Seq_LNCAP_Human1.53716911
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52182237
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49977010
47* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49778613
48* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48418275
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45346177
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44769718
51KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44551639
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43960253
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43328072
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42979294
55* KDM5A_27292631_Chip-Seq_BREAST_Human1.41975081
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41970125
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40410427
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39383920
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.38920132
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38331591
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36500654
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.35977112
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34566544
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25958728
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23792382
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21991659
67VDR_21846776_ChIP-Seq_THP-1_Human1.19137143
68NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.18572602
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17882265
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17713612
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17480880
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.17137442
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16834463
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.13290965
75TFEB_21752829_ChIP-Seq_HELA_Human1.11078334
76FOXP1_21924763_ChIP-Seq_HESCs_Human1.10953006
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10930036
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10315327
79* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10253266
80* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09971793
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09698839
82* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09043332
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08557083
84CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07759101
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06342656
86KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06184745
87KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06184745
88KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06184745
89* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06025632
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05172628
91HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03852862
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02462016
93TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01747817
94ELK1_19687146_ChIP-ChIP_HELA_Human1.01211733
95* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00835530
96* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00229818
97YY1_22570637_ChIP-Seq_MALME-3M_Human0.99246394
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97826261
99TP63_19390658_ChIP-ChIP_HaCaT_Human0.97546708
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97491275
101SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96769173
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95409900
103ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95337623
104* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94692969
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94179403
106EGR1_19374776_ChIP-ChIP_THP-1_Human0.94131571
107NOTCH1_21737748_ChIP-Seq_TLL_Human0.94088165
108CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93711128
109TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93265835
110ZNF263_19887448_ChIP-Seq_K562_Human0.92285225
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91987604
112LXR_22292898_ChIP-Seq_THP-1_Human0.91939830
113NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91694856
114* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.90925214
115ELK3_25401928_ChIP-Seq_HUVEC_Human0.90715968
116* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87481743
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.86906676
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86619109
119TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85855230

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.37023297
2MP0003111_abnormal_nucleus_morphology4.47971185
3MP0004957_abnormal_blastocyst_morpholog4.24619954
4MP0010094_abnormal_chromosome_stability4.21633293
5MP0008057_abnormal_DNA_replication4.00622595
6MP0003077_abnormal_cell_cycle3.79820204
7MP0008058_abnormal_DNA_repair3.04146793
8MP0008932_abnormal_embryonic_tissue2.62328932
9MP0001730_embryonic_growth_arrest2.54946486
10MP0008877_abnormal_DNA_methylation2.49041774
11MP0002653_abnormal_ependyma_morphology2.26429722
12MP0008007_abnormal_cellular_replicative2.21859324
13MP0008260_abnormal_autophagy2.15991618
14MP0010030_abnormal_orbit_morphology2.14629191
15MP0003786_premature_aging2.11015075
16MP0000350_abnormal_cell_proliferation2.07802234
17MP0003123_paternal_imprinting2.01208082
18MP0001697_abnormal_embryo_size1.93199823
19MP0003718_maternal_effect1.91953696
20MP0001672_abnormal_embryogenesis/_devel1.91560100
21MP0005380_embryogenesis_phenotype1.91560100
22MP0003806_abnormal_nucleotide_metabolis1.72993173
23MP0002080_prenatal_lethality1.70949789
24MP0002085_abnormal_embryonic_tissue1.69579665
25MP0002254_reproductive_system_inflammat1.65966215
26MP0003984_embryonic_growth_retardation1.64616911
27MP0001529_abnormal_vocalization1.64313578
28MP0002088_abnormal_embryonic_growth/wei1.62286109
29MP0010352_gastrointestinal_tract_polyps1.62145553
30MP0002210_abnormal_sex_determination1.61971206
31MP0003890_abnormal_embryonic-extraembry1.61618148
32MP0004133_heterotaxia1.61057761
33MP0002084_abnormal_developmental_patter1.59148685
34MP0003567_abnormal_fetal_cardiomyocyte1.57735379
35MP0000490_abnormal_crypts_of1.56017959
36MP0005410_abnormal_fertilization1.55784497
37* MP0001929_abnormal_gametogenesis1.54814987
38MP0003119_abnormal_digestive_system1.52865382
39MP0000313_abnormal_cell_death1.52658052
40MP0005451_abnormal_body_composition1.52401238
41MP0002086_abnormal_extraembryonic_tissu1.51063400
42MP0004185_abnormal_adipocyte_glucose1.48002229
43MP0009697_abnormal_copulation1.46148282
44MP0004197_abnormal_fetal_growth/weight/1.45094864
45MP0001293_anophthalmia1.45013671
46MP0001145_abnormal_male_reproductive1.43855679
47MP0009278_abnormal_bone_marrow1.43730155
48MP0000049_abnormal_middle_ear1.39164599
49MP0005083_abnormal_biliary_tract1.38405184
50MP0002822_catalepsy1.35755582
51MP0010307_abnormal_tumor_latency1.34767987
52MP0002019_abnormal_tumor_incidence1.29610274
53MP0008789_abnormal_olfactory_epithelium1.28505725
54MP0009379_abnormal_foot_pigmentation1.28464713
55MP0005058_abnormal_lysosome_morphology1.28295324
56MP0000358_abnormal_cell_content/1.26800271
57MP0002697_abnormal_eye_size1.25249731
58MP0001545_abnormal_hematopoietic_system1.24507786
59MP0005397_hematopoietic_system_phenotyp1.24507786
60MP0009053_abnormal_anal_canal1.22421581
61MP0004233_abnormal_muscle_weight1.21973871
62MP0002396_abnormal_hematopoietic_system1.21373432
63MP0006036_abnormal_mitochondrial_physio1.21292048
64MP0005501_abnormal_skin_physiology1.19150667
65MP0003646_muscle_fatigue1.18266989
66MP0000653_abnormal_sex_gland1.17766127
67MP0003315_abnormal_perineum_morphology1.16802618
68MP0002269_muscular_atrophy1.16785723
69MP0005499_abnormal_olfactory_system1.15282074
70MP0005394_taste/olfaction_phenotype1.15282074
71MP0009333_abnormal_splenocyte_physiolog1.15047645
72MP0008995_early_reproductive_senescence1.14117483
73* MP0003698_abnormal_male_reproductive1.11490513
74MP0001346_abnormal_lacrimal_gland1.07521255
75MP0004147_increased_porphyrin_level1.07470129
76MP0002796_impaired_skin_barrier1.06801738
77MP0001661_extended_life_span1.06074022
78MP0003221_abnormal_cardiomyocyte_apopto1.05690867
79MP0004858_abnormal_nervous_system1.05226981
80MP0006292_abnormal_olfactory_placode1.04529816
81MP0005076_abnormal_cell_differentiation1.04256664
82MP0004808_abnormal_hematopoietic_stem1.00027623
83MP0000750_abnormal_muscle_regeneration0.96438783
84MP0002877_abnormal_melanocyte_morpholog0.93510011
85MP0006035_abnormal_mitochondrial_morpho0.93072154
86MP0000462_abnormal_digestive_system0.92450928
87MP0003937_abnormal_limbs/digits/tail_de0.92318154
88MP0003942_abnormal_urinary_system0.90695328
89MP0002132_abnormal_respiratory_system0.89845956
90MP0002111_abnormal_tail_morphology0.89642252
91MP0001849_ear_inflammation0.88750162
92MP0003763_abnormal_thymus_physiology0.88559557
93MP0000703_abnormal_thymus_morphology0.88158680
94MP0002160_abnormal_reproductive_system0.87607302
95MP0003941_abnormal_skin_development0.87353574
96MP0003705_abnormal_hypodermis_morpholog0.87314193
97* MP0002161_abnormal_fertility/fecundity0.87045908
98MP0002938_white_spotting0.86867653
99MP0000678_abnormal_parathyroid_gland0.86709761
100MP0002163_abnormal_gland_morphology0.82967412
101MP0005330_cardiomyopathy0.82351831
102MP0005266_abnormal_metabolism0.81481978
103MP0002249_abnormal_larynx_morphology0.81297368
104MP0003385_abnormal_body_wall0.80036213
105MP0001188_hyperpigmentation0.80022390
106MP0009672_abnormal_birth_weight0.79701411
107MP0004084_abnormal_cardiac_muscle0.78860139
108MP0002722_abnormal_immune_system0.75966583
109MP0005384_cellular_phenotype0.75336770
110MP0005075_abnormal_melanosome_morpholog0.75260010
111MP0003186_abnormal_redox_activity0.74331163
112MP0000689_abnormal_spleen_morphology0.74235334
113MP0002089_abnormal_postnatal_growth/wei0.73812480
114MP0005389_reproductive_system_phenotype0.72339078
115MP0001286_abnormal_eye_development0.71422008
116MP0010630_abnormal_cardiac_muscle0.69888699
117MP0001119_abnormal_female_reproductive0.69812183
118MP0002751_abnormal_autonomic_nervous0.68661009
119MP0002398_abnormal_bone_marrow0.67869321
120MP0002127_abnormal_cardiovascular_syste0.66771758
121MP0005621_abnormal_cell_physiology0.66268524
122MP0009840_abnormal_foam_cell0.65842238
123MP0000537_abnormal_urethra_morphology0.63804996
124MP0002233_abnormal_nose_morphology0.62897428
125MP0003283_abnormal_digestive_organ0.62894760
126MP0002092_abnormal_eye_morphology0.62241169
127MP0008770_decreased_survivor_rate0.61984240
128MP0000477_abnormal_intestine_morphology0.61968352
129MP0000372_irregular_coat_pigmentation0.61829940
130MP0004272_abnormal_basement_membrane0.61361726
131MP0003861_abnormal_nervous_system0.60308635
132MP0005174_abnormal_tail_pigmentation0.58293873
133MP0001727_abnormal_embryo_implantation0.57071957
134MP0009703_decreased_birth_body0.57021092
135MP0003566_abnormal_cell_adhesion0.56801981
136MP0003121_genomic_imprinting0.56210866
137MP0003699_abnormal_female_reproductive0.56200824
138MP0005023_abnormal_wound_healing0.54500266
139MP0002429_abnormal_blood_cell0.54445891
140MP0000266_abnormal_heart_morphology0.54037337
141MP0000428_abnormal_craniofacial_morphol0.53692995

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.75080449
2Microvesicular hepatic steatosis (HP:0001414)4.35785492
3Breast hypoplasia (HP:0003187)4.04696273
4Selective tooth agenesis (HP:0001592)4.02817009
5Reticulocytopenia (HP:0001896)3.82349869
6Abnormality of cells of the erythroid lineage (HP:0012130)3.82247722
7Abnormality of the anterior horn cell (HP:0006802)3.67764874
8Degeneration of anterior horn cells (HP:0002398)3.67764874
9Abnormal number of erythroid precursors (HP:0012131)3.65763076
10Patellar aplasia (HP:0006443)3.59761971
11Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.53779732
12Abnormal mitochondria in muscle tissue (HP:0008316)3.51815283
13Absent thumb (HP:0009777)3.47553803
14Rough bone trabeculation (HP:0100670)3.46959538
15Aplasia/Hypoplasia of the patella (HP:0006498)3.43212815
16Absent radius (HP:0003974)3.41082827
17Oral leukoplakia (HP:0002745)3.36277983
18Acute necrotizing encephalopathy (HP:0006965)3.32213151
19Acute encephalopathy (HP:0006846)3.29020097
20Aplasia involving forearm bones (HP:0009822)3.20025198
21Absent forearm bone (HP:0003953)3.20025198
22Hepatocellular necrosis (HP:0001404)3.18911756
23Carpal bone hypoplasia (HP:0001498)3.15279467
24Cerebral hypomyelination (HP:0006808)3.11339962
25Ragged-red muscle fibers (HP:0003200)3.10374102
26Mitochondrial inheritance (HP:0001427)3.02498153
27Ependymoma (HP:0002888)3.00891161
28Impulsivity (HP:0100710)3.00801047
29Multiple enchondromatosis (HP:0005701)2.96663498
30Type I transferrin isoform profile (HP:0003642)2.96552034
31Abnormality of glycolysis (HP:0004366)2.95171251
32Increased CSF lactate (HP:0002490)2.92873714
33Abnormality of the ileum (HP:0001549)2.92568736
34Colon cancer (HP:0003003)2.91468110
35Abnormal umbilical cord blood vessels (HP:0011403)2.84162026
36Abnormality of the fetal cardiovascular system (HP:0010948)2.84162026
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77098569
38Increased hepatocellular lipid droplets (HP:0006565)2.76963504
39Trismus (HP:0000211)2.75719204
40Premature ovarian failure (HP:0008209)2.74946145
41Increased serum pyruvate (HP:0003542)2.74473578
42Increased serum lactate (HP:0002151)2.74222664
43Hepatic necrosis (HP:0002605)2.72330415
44Premature graying of hair (HP:0002216)2.66483815
45Meckel diverticulum (HP:0002245)2.65280461
46Microretrognathia (HP:0000308)2.63261312
47Abnormality of the preputium (HP:0100587)2.61228690
48Tongue fasciculations (HP:0001308)2.60486090
49Increased intramyocellular lipid droplets (HP:0012240)2.60054313
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.58930629
51Aplasia/hypoplasia of the humerus (HP:0006507)2.57994607
52Abnormal gallbladder physiology (HP:0012438)2.57989400
53Cholecystitis (HP:0001082)2.57989400
54Hypoplasia of the capital femoral epiphysis (HP:0003090)2.55495167
55Chromsome breakage (HP:0040012)2.54632715
56Cerebral edema (HP:0002181)2.52524215
57Abnormal number of incisors (HP:0011064)2.52489865
58Rib fusion (HP:0000902)2.52038833
59Rectal fistula (HP:0100590)2.51104770
60Rectovaginal fistula (HP:0000143)2.51104770
61Medulloblastoma (HP:0002885)2.50618547
62Aplastic anemia (HP:0001915)2.50134353
63Supernumerary spleens (HP:0009799)2.48705449
64Myelodysplasia (HP:0002863)2.48593859
65Lipid accumulation in hepatocytes (HP:0006561)2.47401875
66Muscle fibrillation (HP:0010546)2.47323169
67Basal cell carcinoma (HP:0002671)2.45380654
68Macrocytic anemia (HP:0001972)2.45231882
69Lactic acidosis (HP:0003128)2.43870265
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.43761057
71Broad distal phalanx of finger (HP:0009836)2.39713128
72Squamous cell carcinoma (HP:0002860)2.38161512
73Abnormal trabecular bone morphology (HP:0100671)2.38066135
74Exercise intolerance (HP:0003546)2.36462556
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.35568364
76Abnormal protein N-linked glycosylation (HP:0012347)2.35568364
77Abnormal protein glycosylation (HP:0012346)2.35568364
78Abnormal glycosylation (HP:0012345)2.35568364
79Neoplasm of the pancreas (HP:0002894)2.35082031
80Reduced antithrombin III activity (HP:0001976)2.34147746
81Pallor (HP:0000980)2.33479632
82Hypoplasia of the radius (HP:0002984)2.33071268
83Progressive macrocephaly (HP:0004481)2.28422611
84Increased muscle lipid content (HP:0009058)2.27113477
85Concave nail (HP:0001598)2.26743412
86Muscle fiber atrophy (HP:0100295)2.26292392
87Abnormal lung lobation (HP:0002101)2.23791843
88Rhabdomyosarcoma (HP:0002859)2.20980500
89Cellular immunodeficiency (HP:0005374)2.20603488
90Short humerus (HP:0005792)2.19380653
91Intestinal fistula (HP:0100819)2.17959620
92Vaginal fistula (HP:0004320)2.17489548
93Poikiloderma (HP:0001029)2.17102933
94Abnormality of the umbilical cord (HP:0010881)2.16665577
95Bone marrow hypocellularity (HP:0005528)2.16328007
96Progressive muscle weakness (HP:0003323)2.14536994
97Type 2 muscle fiber atrophy (HP:0003554)2.14312904
98Renal Fanconi syndrome (HP:0001994)2.13520026
99Testicular atrophy (HP:0000029)2.13249981
100Abnormality of chromosome stability (HP:0003220)2.12575052
101Ureteral duplication (HP:0000073)2.11968704
102Hypoplastic pelvis (HP:0008839)2.11545817
103Abnormalities of placenta or umbilical cord (HP:0001194)2.11066974
104Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.10764375
105Decreased activity of mitochondrial respiratory chain (HP:0008972)2.10764375
106Abnormality of the labia minora (HP:0012880)2.09952855
107Atrophy/Degeneration involving motor neurons (HP:0007373)2.08800473
108Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07887820
109Tracheoesophageal fistula (HP:0002575)2.06846160
110Horseshoe kidney (HP:0000085)2.05241728
111Cortical dysplasia (HP:0002539)2.05224178
112Small intestinal stenosis (HP:0012848)2.05107598
113Duodenal stenosis (HP:0100867)2.05107598
114Progressive external ophthalmoplegia (HP:0000590)2.01317199
115Respiratory difficulties (HP:0002880)2.01130393
11611 pairs of ribs (HP:0000878)1.99751385
117Facial hemangioma (HP:0000329)1.99542671
118Abnormality of abdominal situs (HP:0011620)1.98657656
119Abdominal situs inversus (HP:0003363)1.98657656
120Hyperglycinemia (HP:0002154)1.98180769
121Triphalangeal thumb (HP:0001199)1.98059956
122Short thumb (HP:0009778)1.97550321
123Sloping forehead (HP:0000340)1.97008662
124Abnormality of reticulocytes (HP:0004312)1.96054865
125Spinal muscular atrophy (HP:0007269)1.95157707
126Personality changes (HP:0000751)1.90668051
127Secondary amenorrhea (HP:0000869)1.90570221
128Agnosia (HP:0010524)1.88970211
129Shoulder girdle muscle weakness (HP:0003547)1.88860223
130Pancytopenia (HP:0001876)1.88273644
131Cleft eyelid (HP:0000625)1.87822357
132High anterior hairline (HP:0009890)1.86711514
133Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.85714918
134Absent epiphyses (HP:0010577)1.85714918
135Asplenia (HP:0001746)1.84909474
136Sparse eyelashes (HP:0000653)1.84903388
137Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.84178456
138Respiratory failure (HP:0002878)1.84072903
139Abnormality of pyrimidine metabolism (HP:0004353)1.84049836
140Spastic diplegia (HP:0001264)1.83138240
141Long palpebral fissure (HP:0000637)1.82787112
142Neoplasm of striated muscle (HP:0009728)1.81348362
143Abnormality of methionine metabolism (HP:0010901)1.81111905
144Duplicated collecting system (HP:0000081)1.79070333
145Slender long bone (HP:0003100)1.78895684
146Atresia of the external auditory canal (HP:0000413)1.78690650
147Male infertility (HP:0003251)1.77722304
148Cafe-au-lait spot (HP:0000957)1.77473384
149Death in infancy (HP:0001522)1.76322278
150Single umbilical artery (HP:0001195)1.76288883
151Hypokinesia (HP:0002375)1.75002280
152Postnatal microcephaly (HP:0005484)1.73452248
153Entropion (HP:0000621)1.70217094
154CNS hypomyelination (HP:0003429)1.69598558
155Facial cleft (HP:0002006)1.69423345
156Septate vagina (HP:0001153)1.69124685
157Poor suck (HP:0002033)1.67889143
158Hypoplastic left heart (HP:0004383)1.64453738
159Nonimmune hydrops fetalis (HP:0001790)1.64312684
160Self-mutilation (HP:0000742)1.62085341
161Leukodystrophy (HP:0002415)1.61991830
162Hypoplasia of the pons (HP:0012110)1.61130708

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.99785377
2VRK24.85190279
3WEE14.09554474
4CDC73.17190593
5SMG13.17054708
6NEK23.06961983
7EIF2AK12.55317542
8PBK2.45001503
9TTK2.36093005
10DYRK32.25639353
11NME22.23475279
12NEK12.18464090
13ICK2.14669163
14NME12.06664169
15PLK12.05706993
16SRPK12.02710912
17MAP3K111.99887177
18ACVR1B1.94584707
19TESK21.93186583
20STK161.87230894
21CDK71.86591071
22PLK41.79137267
23BRSK21.75420712
24PDK41.72763826
25PDK31.72763826
26EPHA21.65005731
27TAF11.64763727
28PASK1.60592398
29CHEK21.58095867
30AURKB1.54499597
31TSSK61.47228894
32ATR1.45237910
33AURKA1.44444463
34TESK11.43606801
35MAP3K101.39922857
36CDK41.38913992
37IRAK31.35107910
38RPS6KB21.28497071
39TLK11.25305108
40BRSK11.23490426
41MAP3K81.23296648
42CHEK11.13828770
43RPS6KA41.13550485
44CCNB11.12323474
45TRIM281.12283708
46EIF2AK31.08527889
47PAK41.07214349
48CDK121.06688980
49BCKDK1.04123357
50DYRK1B1.03393170
51PIM10.98974632
52VRK10.96392427
53TGFBR10.95310507
54PIM20.94148208
55BRAF0.93136895
56CSNK1G30.91747032
57MAP4K10.90318773
58MAP2K30.89098194
59STK40.88807175
60NUAK10.88238654
61STK100.85698477
62PLK30.84953541
63TAOK20.84797726
64CDK20.82225727
65PAK10.81317526
66MKNK10.77891540
67TRIB30.75913264
68MAP3K30.75786159
69SCYL20.74492732
70KDR0.73069799
71PDK20.72289933
72LIMK10.71378385
73CSNK1G10.70827191
74PINK10.70668366
75DDR20.70538880
76TYRO30.70524852
77CSNK1A1L0.68541250
78MAP3K60.68325523
79CSNK2A20.67281117
80CSNK2A10.67026196
81LRRK20.65512090
82PRKCI0.65289540
83ATM0.63287634
84LATS20.62665500
85ZAK0.62036258
86EEF2K0.60184260
87PKN20.60120727
88MTOR0.59807530
89ALK0.58761346
90DYRK20.58280353
91ARAF0.57800726
92FLT30.57796083
93CDK60.57667307
94ABL20.57030247
95DAPK10.56242813
96STK38L0.54979782
97AKT20.54740439
98CDK90.53873880
99ERN10.53628883
100DAPK30.53585324
101MAPKAPK30.53022039
102CDK10.52092590
103MELK0.51779055
104MATK0.51565734
105CSNK1G20.50774192
106BMX0.50661867
107BRD40.49793728
108AKT30.49711061
109SIK10.49169596
110CDK80.48069320
111MKNK20.47912665
112RPS6KA50.46473541
113EIF2AK20.45624063
114ZAP700.44794093
115MAPK110.42358519
116ERBB40.42327092
117TIE10.41921771
118PNCK0.39837071
119RPS6KA10.38989146
120MAPKAPK50.37450434
121MARK30.36429525
122RAF10.36262336
123ILK0.36147868
124CDK190.35151738
125STK30.33412212
126RPS6KC10.33338036
127RPS6KL10.33338036
128MAPK150.32821151
129SIK30.32394890
130IRAK20.30111170
131CDK11A0.29568105
132CDK180.25308380

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.86244329
2Mismatch repair_Homo sapiens_hsa034304.33709506
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.55861392
4Proteasome_Homo sapiens_hsa030503.55068449
5Base excision repair_Homo sapiens_hsa034103.50409232
6Ribosome_Homo sapiens_hsa030103.33710814
7Spliceosome_Homo sapiens_hsa030403.30624090
8RNA transport_Homo sapiens_hsa030133.20311673
9RNA polymerase_Homo sapiens_hsa030203.16952489
10Homologous recombination_Homo sapiens_hsa034402.88031590
11Nucleotide excision repair_Homo sapiens_hsa034202.77432961
12Pyrimidine metabolism_Homo sapiens_hsa002402.47256216
13Cell cycle_Homo sapiens_hsa041102.43514570
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.30388515
15One carbon pool by folate_Homo sapiens_hsa006702.21239697
16Fanconi anemia pathway_Homo sapiens_hsa034602.13910088
17mRNA surveillance pathway_Homo sapiens_hsa030151.89304225
18Basal transcription factors_Homo sapiens_hsa030221.82524900
19RNA degradation_Homo sapiens_hsa030181.64455768
20p53 signaling pathway_Homo sapiens_hsa041151.51562589
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44547723
22Sulfur relay system_Homo sapiens_hsa041221.33651638
23Biosynthesis of amino acids_Homo sapiens_hsa012301.30733963
24Purine metabolism_Homo sapiens_hsa002301.27347777
25Vitamin B6 metabolism_Homo sapiens_hsa007501.25693958
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.20666570
27Folate biosynthesis_Homo sapiens_hsa007901.18593016
28Epstein-Barr virus infection_Homo sapiens_hsa051691.17093969
29Non-homologous end-joining_Homo sapiens_hsa034501.15917841
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14470696
31Fatty acid elongation_Homo sapiens_hsa000621.14217169
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13187688
33Steroid biosynthesis_Homo sapiens_hsa001001.11933013
34Alzheimers disease_Homo sapiens_hsa050101.05645884
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04876340
36Fructose and mannose metabolism_Homo sapiens_hsa000511.00856897
37Oocyte meiosis_Homo sapiens_hsa041141.00555906
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92015168
39Selenocompound metabolism_Homo sapiens_hsa004500.87919093
40Pentose phosphate pathway_Homo sapiens_hsa000300.87684721
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87627479
42Protein export_Homo sapiens_hsa030600.83266136
43Carbon metabolism_Homo sapiens_hsa012000.82904539
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81298387
45Huntingtons disease_Homo sapiens_hsa050160.79290102
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.75625735
47Herpes simplex infection_Homo sapiens_hsa051680.75501767
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73911266
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72972126
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.72784116
51Viral carcinogenesis_Homo sapiens_hsa052030.70000109
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66388514
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66056798
54Glutathione metabolism_Homo sapiens_hsa004800.65981186
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62526654
56Systemic lupus erythematosus_Homo sapiens_hsa053220.61589739
57Notch signaling pathway_Homo sapiens_hsa043300.61040923
58Hippo signaling pathway_Homo sapiens_hsa043900.60276161
59HTLV-I infection_Homo sapiens_hsa051660.58867011
60Fatty acid biosynthesis_Homo sapiens_hsa000610.56642196
61Parkinsons disease_Homo sapiens_hsa050120.53759776
62Legionellosis_Homo sapiens_hsa051340.53631586
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52766367
64Vibrio cholerae infection_Homo sapiens_hsa051100.52447550
65Galactose metabolism_Homo sapiens_hsa000520.51895953
66Basal cell carcinoma_Homo sapiens_hsa052170.51823336
67Antigen processing and presentation_Homo sapiens_hsa046120.51301420
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50654064
69Hedgehog signaling pathway_Homo sapiens_hsa043400.50013213
70Arginine biosynthesis_Homo sapiens_hsa002200.48788227
71Sulfur metabolism_Homo sapiens_hsa009200.48784529
72Arginine and proline metabolism_Homo sapiens_hsa003300.47438081
73Alcoholism_Homo sapiens_hsa050340.46923166
74Bladder cancer_Homo sapiens_hsa052190.45074449
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44724605
76Other glycan degradation_Homo sapiens_hsa005110.43633485
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43156671
78Shigellosis_Homo sapiens_hsa051310.40878692
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40329472
80Small cell lung cancer_Homo sapiens_hsa052220.39654113
81mTOR signaling pathway_Homo sapiens_hsa041500.39519326
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38962856
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38819576
84Regulation of autophagy_Homo sapiens_hsa041400.38411764
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37726744
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37716911
87Pyruvate metabolism_Homo sapiens_hsa006200.36498495
88Fatty acid metabolism_Homo sapiens_hsa012120.36381608
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33842599
90Metabolic pathways_Homo sapiens_hsa011000.33763510
91MicroRNAs in cancer_Homo sapiens_hsa052060.33708105
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.33065363
93Thyroid cancer_Homo sapiens_hsa052160.32659000
94Apoptosis_Homo sapiens_hsa042100.32077439
95TGF-beta signaling pathway_Homo sapiens_hsa043500.31033298
96N-Glycan biosynthesis_Homo sapiens_hsa005100.30076656
97HIF-1 signaling pathway_Homo sapiens_hsa040660.29870146
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29534409
99Peroxisome_Homo sapiens_hsa041460.28794753
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25788706
101Propanoate metabolism_Homo sapiens_hsa006400.25431397
102Oxidative phosphorylation_Homo sapiens_hsa001900.25384787
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24938410
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22043785
105Acute myeloid leukemia_Homo sapiens_hsa052210.20142610
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20116107
107Primary immunodeficiency_Homo sapiens_hsa053400.19966481
108Colorectal cancer_Homo sapiens_hsa052100.19047809
109Phenylalanine metabolism_Homo sapiens_hsa003600.18553039
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16090903
111Lysine degradation_Homo sapiens_hsa003100.15834678
112Linoleic acid metabolism_Homo sapiens_hsa005910.15165077
113Chronic myeloid leukemia_Homo sapiens_hsa052200.14702701
114Measles_Homo sapiens_hsa051620.14658363
115Arachidonic acid metabolism_Homo sapiens_hsa005900.14469387
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.13061392
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12712549
118Cardiac muscle contraction_Homo sapiens_hsa042600.12611523
119Tyrosine metabolism_Homo sapiens_hsa003500.11754777
120Circadian rhythm_Homo sapiens_hsa047100.10757258
121Tight junction_Homo sapiens_hsa045300.10122516
122Pathways in cancer_Homo sapiens_hsa052000.10066307
123Wnt signaling pathway_Homo sapiens_hsa043100.09856527
124Hepatitis B_Homo sapiens_hsa051610.09780353

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