TAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.82864719
2* antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.82864719
3* antigen processing and presentation of endogenous antigen (GO:0019883)7.08063948
4positive regulation of gamma-delta T cell activation (GO:0046645)6.05692776
5positive regulation by symbiont of host defense response (GO:0052509)5.08593543
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.08593543
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.08593543
8regulation of gamma-delta T cell differentiation (GO:0045586)4.96319438
9macrophage activation involved in immune response (GO:0002281)4.69697643
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.64456834
11regulation of gamma-delta T cell activation (GO:0046643)4.61328756
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.27775536
13positive regulation of B cell differentiation (GO:0045579)4.21927772
14detection of other organism (GO:0098543)4.19525100
15detection of bacterium (GO:0016045)4.09971692
16positive thymic T cell selection (GO:0045059)4.08165902
17neutrophil activation involved in immune response (GO:0002283)4.08102000
18negative T cell selection (GO:0043383)3.99974396
19response to peptidoglycan (GO:0032494)3.96871456
20negative thymic T cell selection (GO:0045060)3.96211661
21positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.89518549
22response to type I interferon (GO:0034340)3.88782472
23cellular response to type I interferon (GO:0071357)3.82829103
24type I interferon signaling pathway (GO:0060337)3.82829103
25regulation of B cell receptor signaling pathway (GO:0050855)3.79364177
26response to interleukin-15 (GO:0070672)3.76514995
27regulation of B cell differentiation (GO:0045577)3.70686902
28regulation of interleukin-12 biosynthetic process (GO:0045075)3.64910129
29T cell migration (GO:0072678)3.61146647
30regulation of type I interferon-mediated signaling pathway (GO:0060338)3.61092786
31thymic T cell selection (GO:0045061)3.57660303
32JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.57477173
33ribosomal small subunit assembly (GO:0000028)3.56449484
34NIK/NF-kappaB signaling (GO:0038061)3.54198383
35detection of external biotic stimulus (GO:0098581)3.52527658
36response to host immune response (GO:0052572)3.49636987
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.49636987
38regulation of dendritic cell antigen processing and presentation (GO:0002604)3.49216555
39germinal center formation (GO:0002467)3.42602845
40negative regulation of erythrocyte differentiation (GO:0045647)3.42111549
41negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.41369877
42negative regulation of cell killing (GO:0031342)3.41369877
43response to host defenses (GO:0052200)3.40601282
44response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.40601282
45response to host (GO:0075136)3.40601282
46Arp2/3 complex-mediated actin nucleation (GO:0034314)3.40587084
47regulation of response to interferon-gamma (GO:0060330)3.34691240
48negative regulation of phagocytosis (GO:0050765)3.31903304
49T cell selection (GO:0045058)3.31731070
50B cell receptor signaling pathway (GO:0050853)3.28771169
51leukocyte aggregation (GO:0070486)3.27665730
52positive T cell selection (GO:0043368)3.26810262
53regulation of tolerance induction (GO:0002643)3.26371853
54immunoglobulin mediated immune response (GO:0016064)3.25726680
55positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.23742946
56positive regulation of natural killer cell differentiation (GO:0032825)3.23291652
57negative regulation of lymphocyte mediated immunity (GO:0002707)3.22856859
58detection of molecule of bacterial origin (GO:0032490)3.22719910
59negative regulation of T cell mediated immunity (GO:0002710)3.22323166
60regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.21218892
61T cell homeostasis (GO:0043029)3.19701971
62negative regulation of bone resorption (GO:0045779)3.18476000
63interferon-gamma production (GO:0032609)3.17871407
64interferon-gamma-mediated signaling pathway (GO:0060333)3.16556451
65regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.12682171
66myeloid cell activation involved in immune response (GO:0002275)3.08246945
67tolerance induction (GO:0002507)3.06398169
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.05858048
69detection of biotic stimulus (GO:0009595)3.03962363
70lipopolysaccharide-mediated signaling pathway (GO:0031663)3.03881407
71positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.03844950
72response to interferon-beta (GO:0035456)3.00822495
73microglial cell activation (GO:0001774)2.99224403
74cellular extravasation (GO:0045123)2.98360544
75negative regulation of granulocyte differentiation (GO:0030853)2.98225484
76myeloid dendritic cell activation (GO:0001773)2.96639003
77negative regulation of leukocyte mediated immunity (GO:0002704)2.96560872
78regulation of T cell receptor signaling pathway (GO:0050856)2.96022575
79macrophage activation (GO:0042116)2.93989062
80viral transcription (GO:0019083)2.92495295
81cellular response to interleukin-15 (GO:0071350)2.92197328
82positive regulation of tolerance induction (GO:0002645)2.91353594
83cellular response to interferon-beta (GO:0035458)2.91047851
84response to muramyl dipeptide (GO:0032495)2.88970253
85mast cell activation (GO:0045576)2.88942845
86positive regulation of interferon-alpha production (GO:0032727)2.86290171
87T cell costimulation (GO:0031295)2.84885489
88antigen receptor-mediated signaling pathway (GO:0050851)2.84483115
89positive regulation of histone deacetylation (GO:0031065)2.84036928
90regulation of T cell tolerance induction (GO:0002664)2.83710459
91response to protozoan (GO:0001562)2.83122676
92lymphocyte homeostasis (GO:0002260)2.80968705
93myeloid dendritic cell differentiation (GO:0043011)2.79691330
94negative regulation of cytokine production involved in immune response (GO:0002719)2.79475710
95neutrophil activation (GO:0042119)2.79429821
96lymphocyte costimulation (GO:0031294)2.79100143
97regulation of natural killer cell mediated immunity (GO:0002715)2.78126521
98regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.78126521
99positive regulation of type 2 immune response (GO:0002830)2.77968355
100T cell receptor signaling pathway (GO:0050852)2.77965644
101regulation of T cell mediated cytotoxicity (GO:0001914)2.77660719
102regulation of interferon-beta biosynthetic process (GO:0045357)2.77575998
103cellular response to zinc ion (GO:0071294)2.77495862
104cellular response to interferon-gamma (GO:0071346)2.76804219
105response to interferon-alpha (GO:0035455)2.76302931
106* regulation of antigen processing and presentation (GO:0002577)2.75757423
107positive regulation of interleukin-2 production (GO:0032743)2.74093995
108natural killer cell differentiation (GO:0001779)2.73090593
109T-helper 1 type immune response (GO:0042088)2.73074690
110translational termination (GO:0006415)2.72525387
111regulation of interferon-alpha production (GO:0032647)2.72327633
112production of molecular mediator involved in inflammatory response (GO:0002532)2.72095817
113B cell mediated immunity (GO:0019724)2.71983003
114defense response to protozoan (GO:0042832)2.69756889
115positive regulation of T cell mediated cytotoxicity (GO:0001916)2.69261348
116leukocyte cell-cell adhesion (GO:0007159)2.69055284
117negative regulation of interleukin-6 production (GO:0032715)2.68937382
118regulation of natural killer cell differentiation (GO:0032823)2.68583771
119regulation of myeloid leukocyte mediated immunity (GO:0002886)2.68493021
120granulocyte activation (GO:0036230)2.68437276
121regulation of T-helper 1 cell differentiation (GO:0045625)2.67873675
122regulation of alpha-beta T cell proliferation (GO:0046640)2.67871992
123regulation of T-helper 2 cell differentiation (GO:0045628)2.67236920
124regulation of leukocyte degranulation (GO:0043300)2.66629854
125regulation of mast cell degranulation (GO:0043304)2.65406667
126negative regulation of interleukin-12 production (GO:0032695)2.65323718
127definitive hemopoiesis (GO:0060216)2.62833116
128megakaryocyte development (GO:0035855)2.60293014
129leukocyte homeostasis (GO:0001776)2.59759208
130valine metabolic process (GO:0006573)2.55958282
131positive regulation of protein deacetylation (GO:0090312)2.54501209
132pentose-phosphate shunt (GO:0006098)2.54498271
133negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.54298621
134regulation of necroptotic process (GO:0060544)2.52690749
135angiogenesis involved in wound healing (GO:0060055)2.52608173
136natural killer cell activation (GO:0030101)2.52380881
137positive regulation of humoral immune response (GO:0002922)2.51869847
138regulation of interleukin-2 biosynthetic process (GO:0045076)2.51412309
139mature B cell differentiation (GO:0002335)2.50615765
140lymph node development (GO:0048535)2.50215157
141regulation of hypersensitivity (GO:0002883)2.47518614
142regulation of regulatory T cell differentiation (GO:0045589)2.47226281
143negative regulation of innate immune response (GO:0045824)2.46883987
144Peyers patch development (GO:0048541)2.45680168
145mucosal-associated lymphoid tissue development (GO:0048537)2.45680168
146JAK-STAT cascade (GO:0007259)2.45547608
147modulation by symbiont of host defense response (GO:0052031)2.44969530
148modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.44969530
149modulation by symbiont of host immune response (GO:0052553)2.44969530

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human4.40758623
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.72705093
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.70331873
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.37872744
5* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.29127323
6E2F7_22180533_ChIP-Seq_HELA_Human3.27383680
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.15386542
8MYC_22102868_ChIP-Seq_BL_Human3.10211927
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.03664167
10VDR_21846776_ChIP-Seq_THP-1_Human2.84378693
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.81311182
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.81256495
13SCL_19346495_ChIP-Seq_HPC-7_Human2.67884404
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.57316074
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.53474622
16* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.45587977
17* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.43785896
18MAF_26560356_Chip-Seq_TH1_Human2.42952500
19MYB_26560356_Chip-Seq_TH2_Human2.36601342
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32054133
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29977291
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26257311
23* IRF8_27001747_Chip-Seq_BMDM_Mouse2.26175520
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.25778509
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.21974218
26GATA1_22025678_ChIP-Seq_K562_Human2.16774068
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.13628798
28UTX_26944678_Chip-Seq_JUKART_Human2.08320686
29VDR_24763502_ChIP-Seq_THP-1_Human2.07350003
30* RUNX_20019798_ChIP-Seq_JUKART_Human2.06699179
31* MYB_26560356_Chip-Seq_TH1_Human2.06639983
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.03591025
33BRD4_27068464_Chip-Seq_AML-cells_Mouse2.01240413
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00108083
35SPI1_23547873_ChIP-Seq_NB4_Human1.97822129
36TCF7_22412390_ChIP-Seq_EML_Mouse1.97501201
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.94777687
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.93842479
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83444238
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.80315605
41* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79737284
42ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.78271045
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76110022
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75434814
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72868248
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72106707
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.71089061
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66077830
49MAF_26560356_Chip-Seq_TH2_Human1.60628631
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57059527
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.54502550
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51334930
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51240206
54SPI1_23127762_ChIP-Seq_K562_Human1.47389679
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44618084
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.43133840
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.43115482
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43108414
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41632311
60GATA3_27048872_Chip-Seq_THYMUS_Human1.40516124
61KDM2B_26808549_Chip-Seq_DND41_Human1.39618792
62PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39412252
63* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38219471
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31820083
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31757718
66* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30991585
67RACK7_27058665_Chip-Seq_MCF-7_Human1.30449616
68* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24287393
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24046601
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22935407
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.21243171
72* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20712655
73CIITA_25753668_ChIP-Seq_RAJI_Human1.20494518
74* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19630407
75RXR_22158963_ChIP-Seq_LIVER_Mouse1.19398065
76CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18829121
77RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17277356
78VDR_24787735_ChIP-Seq_THP-1_Human1.16535046
79PU_27001747_Chip-Seq_BMDM_Mouse1.16512009
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15234528
81* GATA1_19941827_ChIP-Seq_MEL_Mouse1.14954767
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13428629
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11867042
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11842403
85LXR_22292898_ChIP-Seq_THP-1_Human1.09878732
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08753267
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08301042
88PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08225038
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04633328
90ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04460580
91CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01430344
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01148550
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99295347
94HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99158667
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98983359
96NCOR1_26117541_ChIP-Seq_K562_Human0.95982307
97PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95630952
98GATA3_26560356_Chip-Seq_TH2_Human0.94693288
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94689747
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.94062714
101SA1_27219007_Chip-Seq_ERYTHROID_Human0.92640134
102P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90794587
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89297446
104KDM2B_26808549_Chip-Seq_K562_Human0.88356658
105* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87276996
106BCOR_27268052_Chip-Seq_Bcells_Human0.87169138
107BCL6_27268052_Chip-Seq_Bcells_Human0.87034929
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85763598
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84988148
110Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84648332
111SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84140240
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83905750
113CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83285306
114EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82986226
115ELF1_20517297_ChIP-Seq_JURKAT_Human0.81912246
116GATA1_19941826_ChIP-Seq_K562_Human0.81666618
117CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81152794
118LXR_22158963_ChIP-Seq_LIVER_Mouse0.80905224
119TP63_17297297_ChIP-ChIP_HaCaT_Human0.80858892
120FOXM1_23109430_ChIP-Seq_U2OS_Human0.80620521
121SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.80305062
122CLOCK_20551151_ChIP-Seq_293T_Human0.79505746
123CTCF_21964334_ChIP-Seq_BJAB-B_Human0.77821859

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation3.74099930
2MP0000685_abnormal_immune_system3.39152000
3MP0005671_abnormal_response_to2.97068201
4MP0003763_abnormal_thymus_physiology2.95090719
5MP0009785_altered_susceptibility_to2.79672580
6MP0001800_abnormal_humoral_immune2.77402751
7MP0005387_immune_system_phenotype2.74820182
8MP0001790_abnormal_immune_system2.74820182
9MP0002396_abnormal_hematopoietic_system2.66810337
10MP0003436_decreased_susceptibility_to2.61838647
11MP0002166_altered_tumor_susceptibility2.58112232
12MP0003303_peritoneal_inflammation2.56565182
13MP0003724_increased_susceptibility_to2.56079187
14MP0005025_abnormal_response_to2.51100758
15MP0005000_abnormal_immune_tolerance2.47692325
16MP0005451_abnormal_body_composition2.45980882
17MP0002452_abnormal_antigen_presenting2.41046506
18MP0003300_gastrointestinal_ulcer2.39525973
19MP0002723_abnormal_immune_serum2.37643468
20* MP0002420_abnormal_adaptive_immunity2.32608596
21* MP0001819_abnormal_immune_cell2.30649591
22MP0002398_abnormal_bone_marrow2.22888540
23MP0005464_abnormal_platelet_physiology2.19422855
24MP0002419_abnormal_innate_immunity2.18144283
25MP0001873_stomach_inflammation2.11044291
26MP0002148_abnormal_hypersensitivity_rea2.00681664
27* MP0000716_abnormal_immune_system2.00422196
28MP0004947_skin_inflammation1.96320649
29MP0010155_abnormal_intestine_physiology1.95763502
30MP0002006_tumorigenesis1.93005395
31MP0009333_abnormal_splenocyte_physiolog1.92167401
32MP0002405_respiratory_system_inflammati1.91892487
33MP0001545_abnormal_hematopoietic_system1.88845306
34MP0005397_hematopoietic_system_phenotyp1.88845306
35MP0000689_abnormal_spleen_morphology1.85986826
36MP0001853_heart_inflammation1.84703544
37MP0002722_abnormal_immune_system1.84421584
38MP0004808_abnormal_hematopoietic_stem1.83216572
39MP0006082_CNS_inflammation1.75790017
40MP0004510_myositis1.75618232
41MP0009278_abnormal_bone_marrow1.75086328
42* MP0002429_abnormal_blood_cell1.73263432
43MP0003191_abnormal_cellular_cholesterol1.72134796
44MP0001845_abnormal_inflammatory_respons1.71177957
45MP0000465_gastrointestinal_hemorrhage1.71050881
46MP0008260_abnormal_autophagy1.63303697
47MP0000703_abnormal_thymus_morphology1.59281949
48MP0009840_abnormal_foam_cell1.58600190
49MP0003866_abnormal_defecation1.56596226
50MP0003705_abnormal_hypodermis_morpholog1.46329422
51MP0008469_abnormal_protein_level1.45217042
52MP0001533_abnormal_skeleton_physiology1.37770988
53MP0002933_joint_inflammation1.26905381
54MP0000858_altered_metastatic_potential1.26044511
55MP0005058_abnormal_lysosome_morphology1.23399180
56MP0003091_abnormal_cell_migration1.21650499
57MP0000490_abnormal_crypts_of1.16768388
58MP0002138_abnormal_hepatobiliary_system1.16237279
59MP0004381_abnormal_hair_follicle1.15478747
60MP0003448_altered_tumor_morphology1.13448787
61MP0005310_abnormal_salivary_gland1.12608834
62MP0010352_gastrointestinal_tract_polyps1.11703448
63MP0005174_abnormal_tail_pigmentation1.10433392
64MP0009764_decreased_sensitivity_to1.05601806
65MP0001851_eye_inflammation1.04574791
66MP0000343_altered_response_to1.02998895
67MP0005075_abnormal_melanosome_morpholog1.01966686
68MP0003172_abnormal_lysosome_physiology1.01564621
69MP0000609_abnormal_liver_physiology0.98336386
70MP0005360_urolithiasis0.96011658
71MP0005023_abnormal_wound_healing0.93424711
72MP0009763_increased_sensitivity_to0.92349466
73MP0002254_reproductive_system_inflammat0.92200158
74MP0002019_abnormal_tumor_incidence0.92079425
75MP0003045_fibrosis0.86288591
76MP0003566_abnormal_cell_adhesion0.85556968
77MP0005164_abnormal_response_to0.85411011
78MP0010307_abnormal_tumor_latency0.82570255
79MP0002332_abnormal_exercise_endurance0.81894323
80MP0004883_abnormal_blood_vessel0.81779266
81MP0006054_spinal_hemorrhage0.80251522
82MP0005365_abnormal_bile_salt0.78799692
83MP0002998_abnormal_bone_remodeling0.77217206
84MP0005390_skeleton_phenotype0.74468156
85MP0001663_abnormal_digestive_system0.73790011
86MP0003795_abnormal_bone_structure0.73606241
87MP0003075_altered_response_to0.73384900
88MP0000249_abnormal_blood_vessel0.73148385
89MP0001348_abnormal_lacrimal_gland0.71551088
90MP0003656_abnormal_erythrocyte_physiolo0.70815881
91MP0000598_abnormal_liver_morphology0.70340395
92MP0003828_pulmonary_edema0.70037077
93MP0008004_abnormal_stomach_pH0.69587934
94MP0004185_abnormal_adipocyte_glucose0.69471701
95MP0002796_impaired_skin_barrier0.68955278
96MP0003690_abnormal_glial_cell0.68557195
97MP0002136_abnormal_kidney_physiology0.67927883
98MP0003183_abnormal_peptide_metabolism0.67636868
99MP0002132_abnormal_respiratory_system0.67198304
100MP0005319_abnormal_enzyme/_coenzyme0.66599336
101MP0003221_abnormal_cardiomyocyte_apopto0.65972387
102MP0004130_abnormal_muscle_cell0.65438891
103MP0010329_abnormal_lipoprotein_level0.65144362
104MP0003453_abnormal_keratinocyte_physiol0.64436439
105MP0002877_abnormal_melanocyte_morpholog0.64367747
106MP0009643_abnormal_urine_homeostasis0.63256669
107MP0010234_abnormal_vibrissa_follicle0.63224347
108MP0002139_abnormal_hepatobiliary_system0.62969051
109MP0001879_abnormal_lymphatic_vessel0.62500692
110MP0005076_abnormal_cell_differentiation0.62022555
111MP0009765_abnormal_xenobiotic_induced0.61738619
112MP0001849_ear_inflammation0.60646322
113MP0005584_abnormal_enzyme/coenzyme_acti0.60213392
114MP0000604_amyloidosis0.58997151
115MP0004264_abnormal_extraembryonic_tissu0.58464371
116MP0008874_decreased_physiological_sensi0.57892638
117MP0005166_decreased_susceptibility_to0.57057274
118MP0001881_abnormal_mammary_gland0.56316935
119MP0008873_increased_physiological_sensi0.55015121
120MP0001216_abnormal_epidermal_layer0.54948264

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.90414593
2Eczematoid dermatitis (HP:0000976)4.72227415
3* Chronic otitis media (HP:0000389)4.56295122
4Recurrent viral infections (HP:0004429)4.22184603
5Recurrent fungal infections (HP:0002841)4.14582566
6IgM deficiency (HP:0002850)4.12966210
7Myositis (HP:0100614)4.09793125
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.01250592
9Recurrent abscess formation (HP:0002722)3.87158140
10* Nasal polyposis (HP:0100582)3.81707232
11Thrombocytosis (HP:0001894)3.81600732
12* Abnormality of the nasal mucosa (HP:0000433)3.78150618
13Panhypogammaglobulinemia (HP:0003139)3.73828969
14* Recurrent bronchitis (HP:0002837)3.65929186
15Recurrent bacterial skin infections (HP:0005406)3.57579339
16T lymphocytopenia (HP:0005403)3.53820439
17Abnormality of T cells (HP:0002843)3.52036511
18Abnormality of T cell number (HP:0011839)3.45863943
19Gastrointestinal inflammation (HP:0004386)3.42792329
20Inflammation of the large intestine (HP:0002037)3.42779372
21Recurrent cutaneous fungal infections (HP:0011370)3.36351203
22Chronic mucocutaneous candidiasis (HP:0002728)3.36351203
23Abnormality of T cell physiology (HP:0011840)3.34682046
24Interstitial pulmonary disease (HP:0006530)3.31511785
25Increased IgE level (HP:0003212)3.30949497
26Spontaneous hematomas (HP:0007420)3.29839983
27Colitis (HP:0002583)3.25188479
28Meningitis (HP:0001287)3.16166058
29Cellulitis (HP:0100658)3.13813402
30Recurrent skin infections (HP:0001581)3.13616379
31Pustule (HP:0200039)3.10195646
32Prolonged bleeding time (HP:0003010)2.98532486
33Autoimmune thrombocytopenia (HP:0001973)2.97363166
34Petechiae (HP:0000967)2.91470264
35Agammaglobulinemia (HP:0004432)2.90004243
36Increased IgM level (HP:0003496)2.87909119
37Epistaxis (HP:0000421)2.84920865
38Vasculitis (HP:0002633)2.84759952
39Keratoconjunctivitis sicca (HP:0001097)2.83932196
40Mediastinal lymphadenopathy (HP:0100721)2.72697403
41Recurrent gram-negative bacterial infections (HP:0005420)2.71669089
42Gingival bleeding (HP:0000225)2.69303171
43Orchitis (HP:0100796)2.69192361
44B lymphocytopenia (HP:0010976)2.69138358
45Abnormality of B cell number (HP:0010975)2.69138358
46Abnormal platelet function (HP:0011869)2.65021228
47Impaired platelet aggregation (HP:0003540)2.65021228
48Lymphopenia (HP:0001888)2.63157429
49Abnormality of macrophages (HP:0004311)2.61528108
50Abnormality of cells of the lymphoid lineage (HP:0012140)2.60246070
51Eosinophilia (HP:0001880)2.57901632
52Granulocytopenia (HP:0001913)2.55762527
53Abnormality of the fingertips (HP:0001211)2.54839327
54Leukocytosis (HP:0001974)2.51974602
55Keratoconjunctivitis (HP:0001096)2.51516206
56Hypergammaglobulinemia (HP:0010702)2.45056571
57Viral hepatitis (HP:0006562)2.44400236
58IgG deficiency (HP:0004315)2.42313737
59Severe combined immunodeficiency (HP:0004430)2.42145604
60Stomatitis (HP:0010280)2.41454480
61Hematochezia (HP:0002573)2.40561064
62Hemoptysis (HP:0002105)2.40253486
63Combined immunodeficiency (HP:0005387)2.40089208
64Papilloma (HP:0012740)2.39847412
65Verrucae (HP:0200043)2.39847412
66Abnormal platelet volume (HP:0011876)2.36502223
67Obstructive lung disease (HP:0006536)2.35493718
68Chronic obstructive pulmonary disease (HP:0006510)2.35493718
69Abnormality of eosinophils (HP:0001879)2.35460849
70Achilles tendon contracture (HP:0001771)2.35131652
71Encephalitis (HP:0002383)2.34582055
72Arterial thrombosis (HP:0004420)2.34440560
73Gastrointestinal stroma tumor (HP:0100723)2.33816388
74Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.33517043
75Thyroiditis (HP:0100646)2.31615856
76Periodontitis (HP:0000704)2.30318494
77Subacute progressive viral hepatitis (HP:0006572)2.27983357
78Chest pain (HP:0100749)2.26859315
79Malnutrition (HP:0004395)2.25195140
80Osteomyelitis (HP:0002754)2.24553447
81Basal ganglia calcification (HP:0002135)2.24029092
82Joint swelling (HP:0001386)2.21867493
83Systemic lupus erythematosus (HP:0002725)2.21748123
84Chronic diarrhea (HP:0002028)2.21169354
85Pulmonary infiltrates (HP:0002113)2.20974055
86IgA deficiency (HP:0002720)2.18800148
87Increased cerebral lipofuscin (HP:0011813)2.17069062
88Gastrointestinal infarctions (HP:0005244)2.15295593
89Retrobulbar optic neuritis (HP:0100654)2.14957675
90Optic neuritis (HP:0100653)2.14957675
91Abnormality of cells of the erythroid lineage (HP:0012130)2.14716514
92* Skin ulcer (HP:0200042)2.14703480
93Fatigue (HP:0012378)2.12250095
94Pulmonary embolism (HP:0002204)2.11579197
95Hypertriglyceridemia (HP:0002155)2.11264752
96Abnormality of the Achilles tendon (HP:0005109)2.10194286
97Autoimmune hemolytic anemia (HP:0001890)2.08799193
98Reduced subcutaneous adipose tissue (HP:0003758)2.08696501
99Hypoplasia of the thymus (HP:0000778)2.08287260
100Abnormal number of erythroid precursors (HP:0012131)2.06163820
101Vacuolated lymphocytes (HP:0001922)2.05225748
102Premature loss of primary teeth (HP:0006323)2.03285955
103Abnormality of the peritoneum (HP:0002585)2.03040995
104Peritonitis (HP:0002586)2.02955957
105Purpura (HP:0000979)2.01574096
106* Emphysema (HP:0002097)2.00383953
107Microcytic anemia (HP:0001935)1.99489378
108Increased serum ferritin (HP:0003281)1.98573135
109Bone pain (HP:0002653)1.98566795
110Gingivitis (HP:0000230)1.98285295
111Sepsis (HP:0100806)1.97659072
112Skin rash (HP:0000988)1.97437045
113Large eyes (HP:0001090)1.97310196
114Loss of speech (HP:0002371)1.97264025
115Urticaria (HP:0001025)1.96501830
116* Chronic sinusitis (HP:0011109)1.96474543
117Gangrene (HP:0100758)1.95969661
118Abnormality of liposaccharide metabolism (HP:0010968)1.95846756
119Abnormality of glycosphingolipid metabolism (HP:0004343)1.95846756
120Abnormality of glycolipid metabolism (HP:0010969)1.95846756
121Recurrent sinusitis (HP:0011108)1.95565085
122* Bronchitis (HP:0012387)1.95550833
123Slow saccadic eye movements (HP:0000514)1.94691877
124Lymphoma (HP:0002665)1.93886611
125Restrictive lung disease (HP:0002091)1.92521418
126Amyloidosis (HP:0011034)1.91805389
127Menorrhagia (HP:0000132)1.90081131
128Glomerulopathy (HP:0100820)1.89567942
129Increased mean platelet volume (HP:0011877)1.89249642
130Acute hepatic failure (HP:0006554)1.88893480
131Arthralgia (HP:0002829)1.88257832
132Anorexia (HP:0002039)1.85780138
133Increased neuronal autofluorescent lipopigment (HP:0002074)1.85562918
134Abnormality of the pleura (HP:0002103)1.85153173

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.66058737
2PRPF4B3.34070080
3TYK22.93602387
4EEF2K2.93160722
5KIT2.78036391
6JAK32.71241297
7ERN12.55203419
8FGFR42.47615681
9TBK12.39883368
10TXK2.29064023
11ZAP702.25724875
12IKBKE2.21072500
13PKN22.20066598
14TRIB32.14178284
15BTK2.05763649
16BLK2.04240807
17JAK11.96723938
18GRK71.86277423
19FLT31.85625787
20MAP3K141.84801131
21STK101.84229722
22MOS1.83584439
23EPHB11.82863394
24TEC1.80337440
25GRK61.79789127
26CSF1R1.72113436
27ITK1.71219851
28SMG11.65343313
29LRRK21.64876580
30TGFBR21.62934145
31MAP3K101.62230434
32KDR1.61396233
33SYK1.59652396
34NME21.53873916
35TAOK31.52048384
36IRAK41.48174033
37FGFR31.47986956
38MAP2K31.37334852
39LCK1.32231844
40IKBKB1.29489776
41CDK121.26644577
42CSK1.25762136
43HCK1.24626496
44NLK1.24357848
45FES1.21569943
46SIK11.20038863
47PIM21.17505825
48EPHA31.14662521
49TAOK21.13738251
50TAOK11.10911264
51IRAK31.10871856
52CDC42BPA1.10465968
53JAK21.08790520
54PTK61.07564111
55FGR1.04355188
56RPS6KA41.02820010
57MAP3K131.01339272
58PIM11.00345190
59KSR20.96258530
60TGFBR10.94856268
61SIK20.90139484
62LYN0.88796382
63MAPKAPK30.88604192
64MST1R0.88443266
65RPS6KB20.85608802
66TTN0.85062044
67ICK0.85055280
68CLK10.81886049
69IRAK20.78585273
70BMPR20.78209014
71CHUK0.76731146
72TIE10.74154329
73SCYL20.72226266
74MST40.71988958
75CDK40.66850490
76RIPK40.66129984
77MAPK110.66124445
78PDPK10.65239974
79MARK30.64790655
80MAP3K60.63873513
81MARK20.63361717
82MAPK70.62071842
83MAP3K70.61538075
84BCKDK0.60290902
85YES10.59488137
86TRPM70.58780487
87HIPK20.58628023
88MATK0.56985034
89PRKD20.56640508
90MAPK40.56050078
91GRK50.54050765
92TESK20.52559519
93MAP3K110.50499195
94MAP3K20.50102209
95PRKCQ0.49947180
96TNK20.47509505
97PTK20.46440660
98PRKCH0.45924159
99STK40.45735953
100RPS6KA60.45316582
101CDK60.43266465
102NEK20.42959072
103MAPKAPK20.41493689
104PAK40.40525266
105RAF10.39652759
106MAP3K30.39207574
107CAMK1D0.38071993
108RET0.37870285
109PDK10.37627188
110FYN0.37075654
111MAP3K80.36961898
112PDGFRA0.36902163
113BMX0.36228387
114RIPK10.35941959
115MELK0.35558531
116PASK0.34754233
117RPS6KL10.34150231
118RPS6KC10.34150231
119ABL10.32726503
120NEK90.32587648
121SIK30.32401297
122ALK0.32266989
123SGK30.31364602
124IRAK10.29992913
125MAPK120.28640250
126EGFR0.28502342
127PRKG20.28104227
128MAPK30.27128127
129MAP3K10.25360750
130PIK3CG0.25182471

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary immunodeficiency_Homo sapiens_hsa053403.77450359
2Leishmaniasis_Homo sapiens_hsa051402.62041733
3Measles_Homo sapiens_hsa051622.48981611
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.46289661
5B cell receptor signaling pathway_Homo sapiens_hsa046622.40742454
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.32761245
7* Antigen processing and presentation_Homo sapiens_hsa046122.25945570
8Osteoclast differentiation_Homo sapiens_hsa043802.23887558
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.23037099
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.00749529
11Hematopoietic cell lineage_Homo sapiens_hsa046402.00548160
12T cell receptor signaling pathway_Homo sapiens_hsa046601.96106033
13Caffeine metabolism_Homo sapiens_hsa002321.93591867
14Type I diabetes mellitus_Homo sapiens_hsa049401.93412877
15Staphylococcus aureus infection_Homo sapiens_hsa051501.93203904
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.93165553
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.82557948
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79713109
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73675096
20* Herpes simplex infection_Homo sapiens_hsa051681.70906549
21Acute myeloid leukemia_Homo sapiens_hsa052211.70449440
22Toxoplasmosis_Homo sapiens_hsa051451.68580961
23Ribosome_Homo sapiens_hsa030101.56432068
24Influenza A_Homo sapiens_hsa051641.53145356
25Legionellosis_Homo sapiens_hsa051341.49034202
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43760499
27Pertussis_Homo sapiens_hsa051331.39864883
28Allograft rejection_Homo sapiens_hsa053301.38346785
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35662981
30Apoptosis_Homo sapiens_hsa042101.33916583
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.33146023
32Malaria_Homo sapiens_hsa051441.31295223
33Hepatitis B_Homo sapiens_hsa051611.29336194
34Shigellosis_Homo sapiens_hsa051311.26089866
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25354871
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24393403
37TNF signaling pathway_Homo sapiens_hsa046681.21829538
38Tuberculosis_Homo sapiens_hsa051521.21490382
39Viral myocarditis_Homo sapiens_hsa054161.20861135
40DNA replication_Homo sapiens_hsa030301.16331072
41Other glycan degradation_Homo sapiens_hsa005111.15897707
42Chemokine signaling pathway_Homo sapiens_hsa040621.14403161
43Chronic myeloid leukemia_Homo sapiens_hsa052201.12830050
44Pentose phosphate pathway_Homo sapiens_hsa000301.12564980
45Hepatitis C_Homo sapiens_hsa051601.04881542
46Platelet activation_Homo sapiens_hsa046111.04345866
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03974554
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02295170
49Rheumatoid arthritis_Homo sapiens_hsa053231.01349396
50* Phagosome_Homo sapiens_hsa041451.01009659
51Graft-versus-host disease_Homo sapiens_hsa053321.00084954
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96006309
53Pancreatic cancer_Homo sapiens_hsa052120.90064366
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89380824
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.88958583
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.86788864
57Sulfur relay system_Homo sapiens_hsa041220.86702317
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85445582
59Prolactin signaling pathway_Homo sapiens_hsa049170.81922348
60Small cell lung cancer_Homo sapiens_hsa052220.77753523
61Renal cell carcinoma_Homo sapiens_hsa052110.75713611
62HTLV-I infection_Homo sapiens_hsa051660.75316942
63Salmonella infection_Homo sapiens_hsa051320.74437788
64Base excision repair_Homo sapiens_hsa034100.73537116
65Insulin resistance_Homo sapiens_hsa049310.73266473
66Epstein-Barr virus infection_Homo sapiens_hsa051690.73220961
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71892309
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70353872
69Viral carcinogenesis_Homo sapiens_hsa052030.68857037
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68554649
71Complement and coagulation cascades_Homo sapiens_hsa046100.67912848
72Bladder cancer_Homo sapiens_hsa052190.65938558
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64589299
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.63162895
75Autoimmune thyroid disease_Homo sapiens_hsa053200.61442957
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61436433
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.60838177
78Asthma_Homo sapiens_hsa053100.60063839
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59305101
80Non-small cell lung cancer_Homo sapiens_hsa052230.59102970
81Endocytosis_Homo sapiens_hsa041440.58968325
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.57931382
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.57879037
84Non-homologous end-joining_Homo sapiens_hsa034500.57824002
85VEGF signaling pathway_Homo sapiens_hsa043700.57669917
86Lysosome_Homo sapiens_hsa041420.57061708
87Inositol phosphate metabolism_Homo sapiens_hsa005620.55796078
88Endometrial cancer_Homo sapiens_hsa052130.55360264
89Fatty acid degradation_Homo sapiens_hsa000710.53603129
90African trypanosomiasis_Homo sapiens_hsa051430.52997755
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52736235
92Notch signaling pathway_Homo sapiens_hsa043300.52370852
93GnRH signaling pathway_Homo sapiens_hsa049120.51776246
94One carbon pool by folate_Homo sapiens_hsa006700.51287760
95HIF-1 signaling pathway_Homo sapiens_hsa040660.50952202
96Prion diseases_Homo sapiens_hsa050200.49923948
97FoxO signaling pathway_Homo sapiens_hsa040680.49659862
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47496353
99* ABC transporters_Homo sapiens_hsa020100.47362413
100Prostate cancer_Homo sapiens_hsa052150.47236166
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.47096090
102Choline metabolism in cancer_Homo sapiens_hsa052310.46073757
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42563833
104Glioma_Homo sapiens_hsa052140.41224382
105Mismatch repair_Homo sapiens_hsa034300.41101942
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40406580
107PPAR signaling pathway_Homo sapiens_hsa033200.39705225
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39238059
109mTOR signaling pathway_Homo sapiens_hsa041500.38706666
110Thyroid cancer_Homo sapiens_hsa052160.38435274
111ErbB signaling pathway_Homo sapiens_hsa040120.37394059
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37169171
113p53 signaling pathway_Homo sapiens_hsa041150.36632401
114Dorso-ventral axis formation_Homo sapiens_hsa043200.36473980
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36225020
116N-Glycan biosynthesis_Homo sapiens_hsa005100.36094633
117Proteoglycans in cancer_Homo sapiens_hsa052050.35801887
118Galactose metabolism_Homo sapiens_hsa000520.35613908
119Focal adhesion_Homo sapiens_hsa045100.35507483
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35468658
121Systemic lupus erythematosus_Homo sapiens_hsa053220.35188350
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34146581
123Selenocompound metabolism_Homo sapiens_hsa004500.33470861
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.32582750
125Colorectal cancer_Homo sapiens_hsa052100.31416446
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.30682692
127Amoebiasis_Homo sapiens_hsa051460.30595305
128Lysine degradation_Homo sapiens_hsa003100.28625532

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