TAOK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.16132676
2locomotory exploration behavior (GO:0035641)4.02424996
3positive regulation of histone deacetylation (GO:0031065)3.68073509
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.65411484
5cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.63129982
6cytoskeletal anchoring at plasma membrane (GO:0007016)3.62035349
7negative regulation of cell size (GO:0045792)3.59284048
8activation of protein kinase A activity (GO:0034199)3.57378600
9regulation of ARF protein signal transduction (GO:0032012)3.56136653
10sodium ion export (GO:0071436)3.54909287
11regulation of short-term neuronal synaptic plasticity (GO:0048172)3.53860077
12layer formation in cerebral cortex (GO:0021819)3.48592521
13* adherens junction assembly (GO:0034333)3.42305168
14cell communication by electrical coupling (GO:0010644)3.37836525
15semaphorin-plexin signaling pathway (GO:0071526)3.37362300
16mannose metabolic process (GO:0006013)3.35726080
17regulation of early endosome to late endosome transport (GO:2000641)3.34522927
18regulation of ARF GTPase activity (GO:0032312)3.30498106
19Golgi transport vesicle coating (GO:0048200)3.27807026
20COPI coating of Golgi vesicle (GO:0048205)3.27807026
21basement membrane organization (GO:0071711)3.23070742
22cerebellar Purkinje cell layer development (GO:0021680)3.15788281
23regulation of mammary gland epithelial cell proliferation (GO:0033599)3.15428231
24insulin-like growth factor receptor signaling pathway (GO:0048009)3.08469894
25activation of Rac GTPase activity (GO:0032863)3.08057235
26negative regulation of fatty acid transport (GO:2000192)3.06347051
27apoptotic process involved in morphogenesis (GO:0060561)3.05825398
28barbed-end actin filament capping (GO:0051016)2.99838636
29regulation of synapse structural plasticity (GO:0051823)2.99036792
30regulation of glucose import in response to insulin stimulus (GO:2001273)2.99020517
31* cell-substrate adherens junction assembly (GO:0007045)2.98554532
32* focal adhesion assembly (GO:0048041)2.98554532
33positive regulation of Rap GTPase activity (GO:0032854)2.96657578
34planar cell polarity pathway involved in neural tube closure (GO:0090179)2.96639842
35* cell-substrate junction assembly (GO:0007044)2.96595165
36vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.95598863
37peptidyl-lysine dimethylation (GO:0018027)2.93958265
38positive regulation of receptor recycling (GO:0001921)2.93097594
39activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.92570222
40negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.88540436
41synaptic vesicle docking involved in exocytosis (GO:0016081)2.86850960
42positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.83612417
43stress fiber assembly (GO:0043149)2.80275531
44regulation of NFAT protein import into nucleus (GO:0051532)2.79746375
45positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.78765617
46plasma membrane repair (GO:0001778)2.78259948
47establishment of nucleus localization (GO:0040023)2.78235014
48macroautophagy (GO:0016236)2.76115877
49dendritic spine morphogenesis (GO:0060997)2.75332682
50positive regulation of nuclease activity (GO:0032075)2.75027729
51regulation of extracellular matrix disassembly (GO:0010715)2.74077038
52vascular endothelial growth factor signaling pathway (GO:0038084)2.72352405
53positive regulation of blood vessel endothelial cell migration (GO:0043536)2.71767123
54response to laminar fluid shear stress (GO:0034616)2.70298323
55membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.69578889
56epithelial cell-cell adhesion (GO:0090136)2.68927832
57regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.67571351
58G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.67372159
59maternal placenta development (GO:0001893)2.66868175
60stress granule assembly (GO:0034063)2.66843744
61retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.65212688
62growth hormone secretion (GO:0030252)2.64108086
63positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.62184886
64epithelial cell differentiation involved in prostate gland development (GO:0060742)2.61940462
65cytoplasmic mRNA processing body assembly (GO:0033962)2.60150838
66regulation of Rap GTPase activity (GO:0032317)2.59563436
67cell-cell junction maintenance (GO:0045217)2.59311927
68pre-miRNA processing (GO:0031054)2.59044884
69positive regulation of glycogen biosynthetic process (GO:0045725)2.58874607
70positive regulation of Cdc42 GTPase activity (GO:0043089)2.58749240
71embryonic process involved in female pregnancy (GO:0060136)2.58414290
72cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.57799562
73protein localization to endosome (GO:0036010)2.57684215
74neuromuscular process controlling balance (GO:0050885)2.56692538
75protein targeting to plasma membrane (GO:0072661)2.55287879
76cell communication involved in cardiac conduction (GO:0086065)2.54024209
77potassium ion import (GO:0010107)2.53307139
78regulation of glutamate receptor signaling pathway (GO:1900449)2.51286030
79proline transport (GO:0015824)2.49663649
80establishment of protein localization to Golgi (GO:0072600)2.48168054
81maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.48167606
82negative regulation of potassium ion transmembrane transport (GO:1901380)2.48129585
83negative regulation of erythrocyte differentiation (GO:0045647)2.47089680
84regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.47064727
85negative regulation of nucleotide catabolic process (GO:0030812)2.47017242
86cortical actin cytoskeleton organization (GO:0030866)2.47014914
87vocalization behavior (GO:0071625)2.46940101
88regulation of synaptic vesicle exocytosis (GO:2000300)2.45603527
89signal complex assembly (GO:0007172)2.45267950
90nerve growth factor signaling pathway (GO:0038180)2.43613144
91regulation of nuclease activity (GO:0032069)2.43444235
92proline biosynthetic process (GO:0006561)2.43121964
93clathrin coat assembly (GO:0048268)2.42566609
94negative regulation of myotube differentiation (GO:0010832)2.41753634
95protein retention in ER lumen (GO:0006621)2.41606047
96lymph vessel development (GO:0001945)2.41352631
97exploration behavior (GO:0035640)2.41342074
98protein targeting to Golgi (GO:0000042)2.40546327
99endothelial cell chemotaxis (GO:0035767)2.39886048
100hemidesmosome assembly (GO:0031581)2.39142872
101regulation of p38MAPK cascade (GO:1900744)2.39013991
102atrioventricular valve morphogenesis (GO:0003181)2.38992981
103membrane repolarization during action potential (GO:0086011)2.38877874
104cellular potassium ion homeostasis (GO:0030007)2.37602191
105positive regulation of protein dephosphorylation (GO:0035307)2.37396934
106dendrite morphogenesis (GO:0048813)2.37229398
107glutamate secretion (GO:0014047)2.36686387
108cAMP biosynthetic process (GO:0006171)2.36535119
109dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.36203011
110vesicle coating (GO:0006901)2.35999419
111retrograde transport, vesicle recycling within Golgi (GO:0000301)2.35048625
112intracellular estrogen receptor signaling pathway (GO:0030520)2.34384601
113cell volume homeostasis (GO:0006884)2.33588220
114skin morphogenesis (GO:0043589)2.31939504
115activation of MAPKKK activity (GO:0000185)2.31658770
116positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.30915816
117glucocorticoid receptor signaling pathway (GO:0042921)2.29691810
118glial cell proliferation (GO:0014009)2.29021883
119apoptotic cell clearance (GO:0043277)2.28762657
120endoplasmic reticulum unfolded protein response (GO:0030968)2.27083614
121pinocytosis (GO:0006907)2.26983808
122surfactant homeostasis (GO:0043129)2.25836608
123positive regulation of synapse maturation (GO:0090129)2.25104875
124regulation of polysaccharide biosynthetic process (GO:0032885)2.24499681
125negative regulation of viral release from host cell (GO:1902187)2.24286125
126endocytic recycling (GO:0032456)2.24054541
127modulation by symbiont of host cellular process (GO:0044068)2.23482670
128actin filament bundle assembly (GO:0051017)2.22919973
129actin filament bundle organization (GO:0061572)2.22919973
130membrane repolarization (GO:0086009)2.22856780
131alanine transport (GO:0032328)2.22508482
132regulation of cholesterol homeostasis (GO:2000188)2.21688772
133activation of JUN kinase activity (GO:0007257)2.21642269
134positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.21395678
135regulation of fatty acid beta-oxidation (GO:0031998)2.21150631
136regulation of histone H3-K27 methylation (GO:0061085)2.20968161
137peptidyl-tyrosine autophosphorylation (GO:0038083)2.20429862
138negative regulation of cell killing (GO:0031342)2.20006313
139negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.20006313
140cellular response to epidermal growth factor stimulus (GO:0071364)2.19087882
141L-alpha-amino acid transmembrane transport (GO:1902475)2.18846893
142negative regulation of cytosolic calcium ion concentration (GO:0051481)2.18639971
143regulation of neuronal synaptic plasticity (GO:0048168)2.18428425
144positive regulation of protein deacetylation (GO:0090312)2.18258879
145regulation of nucleobase-containing compound transport (GO:0032239)2.17828989
146regulation of synaptic vesicle transport (GO:1902803)2.17731597
147modulation by virus of host morphology or physiology (GO:0019048)2.17719525
148positive regulation of glycogen metabolic process (GO:0070875)2.17130427
149vesicle transport along microtubule (GO:0047496)2.16403775
150cortical cytoskeleton organization (GO:0030865)2.15646154
151suckling behavior (GO:0001967)2.15495307
152regulation of cholesterol biosynthetic process (GO:0045540)2.15390220
153response to fluid shear stress (GO:0034405)2.14953735
154negative regulation of GTP catabolic process (GO:0033125)2.14665694
155negative regulation of GTPase activity (GO:0034260)2.14665694
156cellular response to unfolded protein (GO:0034620)2.14206199
157neurotransmitter secretion (GO:0007269)2.13499342
158ER-nucleus signaling pathway (GO:0006984)2.13351009
159cerebellar Purkinje cell differentiation (GO:0021702)2.13171243
160regulation of long-term neuronal synaptic plasticity (GO:0048169)2.12193268
161glycine transport (GO:0015816)2.12008096
162negative regulation of purine nucleotide catabolic process (GO:0033122)2.11800839
163positive regulation of myotube differentiation (GO:0010831)2.11295894
164branching involved in mammary gland duct morphogenesis (GO:0060444)2.10772690
165embryo implantation (GO:0007566)2.09102203
166glucose 6-phosphate metabolic process (GO:0051156)2.06868131
167blood vessel endothelial cell migration (GO:0043534)2.04454721
168regulation of extracellular matrix organization (GO:1903053)2.03618862
169low-density lipoprotein particle clearance (GO:0034383)2.02220143
170negative regulation of focal adhesion assembly (GO:0051895)1.97780759
171negative regulation of cell junction assembly (GO:1901889)1.97780759
172negative regulation of adherens junction organization (GO:1903392)1.97780759

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.34181090
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.07236281
3KDM2B_26808549_Chip-Seq_SUP-B15_Human2.68599686
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.67454318
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.65007954
6KDM2B_26808549_Chip-Seq_DND41_Human2.56188110
7MYC_22102868_ChIP-Seq_BL_Human2.52516104
8KDM2B_26808549_Chip-Seq_K562_Human2.36282147
9TCF7_22412390_ChIP-Seq_EML_Mouse2.29158460
10EZH2_22144423_ChIP-Seq_EOC_Human2.28075311
11LXR_22292898_ChIP-Seq_THP-1_Human2.20587130
12DROSHA_22980978_ChIP-Seq_HELA_Human2.20558069
13ZFP281_18757296_ChIP-ChIP_E14_Mouse2.18204572
14KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.17172339
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.10429313
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.10008556
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.08971750
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02720863
19* DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.00778632
20ZFP281_27345836_Chip-Seq_ESCs_Mouse2.00246072
21KDM2B_26808549_Chip-Seq_JURKAT_Human1.96744670
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.94659890
23* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.88687716
24WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.82937641
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.81568738
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77080922
27SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.73143146
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.70894017
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.69738073
30VDR_21846776_ChIP-Seq_THP-1_Human1.67489027
31GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.66227406
32DNAJC2_21179169_ChIP-ChIP_NT2_Human1.60130933
33TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56760632
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55088359
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.52909654
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52149425
37P300_27058665_Chip-Seq_ZR-75-30cells_Human1.50519170
38CREB1_26743006_Chip-Seq_LNCaP_Human1.49677251
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49000376
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46737261
41GATA1_19941826_ChIP-Seq_K562_Human1.44853661
42SPI1_23127762_ChIP-Seq_K562_Human1.44771597
43CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.44532670
44RACK7_27058665_Chip-Seq_MCF-7_Human1.43722999
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.41700356
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.41626176
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41075415
48VDR_24763502_ChIP-Seq_THP-1_Human1.40320587
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37864215
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36176718
51NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36047082
52SA1_27219007_Chip-Seq_ERYTHROID_Human1.35743614
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.34607517
54WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33483073
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32158587
56ZNF263_19887448_ChIP-Seq_K562_Human1.31063509
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30423848
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28433556
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27881972
60TP53_22127205_ChIP-Seq_IMR90_Human1.27725676
61SMC4_20622854_ChIP-Seq_HELA_Human1.27394021
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.25923943
63TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.25601232
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24159868
65CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24003518
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23591186
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21904853
68NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21894776
69TBX20_22328084_ChIP-Seq_HEART_Mouse1.20957079
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.20957079
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20206653
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.19939308
73UTX_26944678_Chip-Seq_JUKART_Human1.19380112
74* P68_20966046_ChIP-Seq_HELA_Human1.18684616
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18463763
76SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18068011
77* REST_21632747_ChIP-Seq_MESCs_Mouse1.17615591
78RUNX1_27514584_Chip-Seq_MCF-7_Human1.16766760
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16600546
80MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16261908
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16155315
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15205884
83REST_18959480_ChIP-ChIP_MESCs_Mouse1.15085959
84SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12930348
85ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12500215
86ATF3_27146783_Chip-Seq_COLON_Human1.12436102
87BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12117077
88FOXA2_19822575_ChIP-Seq_HepG2_Human1.11258409
89FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.11075386
90EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10397905
91RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10397905
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10341396
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10192998
94MAF_26560356_Chip-Seq_TH1_Human1.10121146
95CTCF_27219007_Chip-Seq_Bcells_Human1.09956906
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09904507
97UBF1/2_26484160_Chip-Seq_HMECs_Human1.08924193
98CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08483000
99* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07991628
100NCOR1_26117541_ChIP-Seq_K562_Human1.07421509
101RUNX1_22412390_ChIP-Seq_EML_Mouse1.06192328
102MAF_26560356_Chip-Seq_TH2_Human1.05429723
103UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04127768
104ESR1_21235772_ChIP-Seq_MCF-7_Human1.03959868
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03144197
106CLOCK_20551151_ChIP-Seq_293T_Human1.02929523
107RNF2_27304074_Chip-Seq_ESCs_Mouse1.02426433
108* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02315681
109RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01826042
110* ELF1_20517297_ChIP-Seq_JURKAT_Human1.01227555
111TET1_21490601_ChIP-Seq_MESCs_Mouse1.00403896
112ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00400620
113MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99606039
114GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99398488
115SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99286084
116RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99003053
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98366122
118SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98267163
119SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97927025
120EZH2_27294783_Chip-Seq_ESCs_Mouse0.97882841
121TP63_22573176_ChIP-Seq_HFKS_Human0.97783104
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97744794
123SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97494278
124SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96741374
125KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96694325
126RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96264219
127SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95909699
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93966184
129GATA2_21666600_ChIP-Seq_HMVEC_Human0.93900580
130AR_19668381_ChIP-Seq_PC3_Human0.93609112
131JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93523111
132PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93387254
133* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93302489
134FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92974083
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92721448
136GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91263732
137OCT4_19829295_ChIP-Seq_ESCs_Human0.91001822
138ISL1_27105846_Chip-Seq_CPCs_Mouse0.90458481

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.43864204
2MP0003283_abnormal_digestive_organ3.65126445
3MP0002909_abnormal_adrenal_gland3.58963737
4MP0008438_abnormal_cutaneous_collagen3.32200894
5MP0009780_abnormal_chondrocyte_physiolo3.29030017
6MP0008961_abnormal_basal_metabolism3.27253276
7MP0003705_abnormal_hypodermis_morpholog2.90869075
8MP0000569_abnormal_digit_pigmentation2.90733402
9MP0005409_darkened_coat_color2.78787715
10MP0005451_abnormal_body_composition2.74472762
11MP0003300_gastrointestinal_ulcer2.69872856
12MP0002877_abnormal_melanocyte_morpholog2.68456581
13MP0005058_abnormal_lysosome_morphology2.66919610
14MP0005076_abnormal_cell_differentiation2.16778457
15MP0000013_abnormal_adipose_tissue2.14936667
16MP0004272_abnormal_basement_membrane2.13444868
17MP0001958_emphysema2.10629486
18MP0008260_abnormal_autophagy1.98672673
19MP0004858_abnormal_nervous_system1.97590652
20MP0003635_abnormal_synaptic_transmissio1.96154306
21MP0003303_peritoneal_inflammation1.94394684
22MP0009278_abnormal_bone_marrow1.92656306
23MP0009840_abnormal_foam_cell1.85803030
24MP0003045_fibrosis1.81695751
25MP0004130_abnormal_muscle_cell1.80430640
26MP0000003_abnormal_adipose_tissue1.79848599
27MP0003453_abnormal_keratinocyte_physiol1.69137660
28MP0001944_abnormal_pancreas_morphology1.68779374
29MP0002249_abnormal_larynx_morphology1.68771286
30MP0003172_abnormal_lysosome_physiology1.67454534
31MP0005167_abnormal_blood-brain_barrier1.66514725
32MP0005257_abnormal_intraocular_pressure1.64375504
33MP0004510_myositis1.60839570
34MP0002837_dystrophic_cardiac_calcinosis1.60261725
35MP0004270_analgesia1.58632505
36MP0010234_abnormal_vibrissa_follicle1.55100535
37MP0010368_abnormal_lymphatic_system1.49686095
38MP0000751_myopathy1.48292812
39MP0005375_adipose_tissue_phenotype1.46840859
40MP0000767_abnormal_smooth_muscle1.45121320
41MP0001849_ear_inflammation1.43415626
42MP0002693_abnormal_pancreas_physiology1.42707750
43MP0004084_abnormal_cardiac_muscle1.38752257
44MP0002928_abnormal_bile_duct1.37460071
45MP0003252_abnormal_bile_duct1.37190097
46MP0002063_abnormal_learning/memory/cond1.34904780
47MP0004811_abnormal_neuron_physiology1.33549345
48MP0002822_catalepsy1.30900111
49MP0004885_abnormal_endolymph1.27837881
50MP0004185_abnormal_adipocyte_glucose1.27819961
51MP0002078_abnormal_glucose_homeostasis1.27644716
52MP0005023_abnormal_wound_healing1.24634691
53MP0005275_abnormal_skin_tensile1.22645655
54MP0003566_abnormal_cell_adhesion1.22561782
55MP0003787_abnormal_imprinting1.21023852
56MP0005666_abnormal_adipose_tissue1.18942417
57MP0010352_gastrointestinal_tract_polyps1.17698518
58MP0005187_abnormal_penis_morphology1.17608258
59MP0010630_abnormal_cardiac_muscle1.16876871
60MP0003119_abnormal_digestive_system1.16834550
61MP0001915_intracranial_hemorrhage1.16055960
62MP0004947_skin_inflammation1.15852154
63MP0000858_altered_metastatic_potential1.15817721
64MP0002060_abnormal_skin_morphology1.15048922
65MP0008569_lethality_at_weaning1.14635966
66MP0003122_maternal_imprinting1.14569353
67MP0004087_abnormal_muscle_fiber1.11995128
68MP0003436_decreased_susceptibility_to1.10509036
69MP0001348_abnormal_lacrimal_gland1.09888444
70MP0006138_congestive_heart_failure1.07732063
71MP0004233_abnormal_muscle_weight1.06481583
72MP0002796_impaired_skin_barrier1.05722602
73MP0005670_abnormal_white_adipose1.04525735
74MP0002234_abnormal_pharynx_morphology1.04497868
75MP0004043_abnormal_pH_regulation1.03364072
76MP0002998_abnormal_bone_remodeling1.03058395
77MP0000759_abnormal_skeletal_muscle1.02878336
78MP0003075_altered_response_to1.02127321
79MP0003828_pulmonary_edema1.00834284
80MP0004085_abnormal_heartbeat1.00723460
81MP0003879_abnormal_hair_cell1.00533192
82MP0003634_abnormal_glial_cell0.99983477
83MP0000955_abnormal_spinal_cord0.99866216
84MP0003690_abnormal_glial_cell0.99862187
85MP0003633_abnormal_nervous_system0.99493374
86MP0000678_abnormal_parathyroid_gland0.99438578
87MP0000604_amyloidosis0.98553787
88MP0002269_muscular_atrophy0.97685123
89MP0005621_abnormal_cell_physiology0.95123091
90MP0005503_abnormal_tendon_morphology0.93801905
91MP0001879_abnormal_lymphatic_vessel0.93241972
92MP0003329_amyloid_beta_deposits0.93231453
93MP0009384_cardiac_valve_regurgitation0.92684082
94MP0004782_abnormal_surfactant_physiolog0.92588946
95MP0005623_abnormal_meninges_morphology0.91338181
96MP0009672_abnormal_birth_weight0.91070935
97MP0002089_abnormal_postnatal_growth/wei0.89667798
98MP0000534_abnormal_ureter_morphology0.88685158
99MP0004036_abnormal_muscle_relaxation0.88257823
100MP0004264_abnormal_extraembryonic_tissu0.87924352
101MP0002896_abnormal_bone_mineralization0.86850718
102MP0002925_abnormal_cardiovascular_devel0.86633355
103MP0009745_abnormal_behavioral_response0.86437197
104MP0002653_abnormal_ependyma_morphology0.86036178
105MP0000681_abnormal_thyroid_gland0.85633673
106MP0005501_abnormal_skin_physiology0.84669236
107MP0000266_abnormal_heart_morphology0.84580464
108MP0002064_seizures0.83581544
109MP0000747_muscle_weakness0.81371060
110MP0003091_abnormal_cell_migration0.79497240
111MP0001614_abnormal_blood_vessel0.78547679
112MP0003183_abnormal_peptide_metabolism0.78387886
113MP0008874_decreased_physiological_sensi0.77082740
114MP0003868_abnormal_feces_composition0.76709853
115MP0000428_abnormal_craniofacial_morphol0.76686940
116MP0001730_embryonic_growth_arrest0.76061879
117MP0003115_abnormal_respiratory_system0.75686724
118MP0000733_abnormal_muscle_development0.75019187
119MP0002572_abnormal_emotion/affect_behav0.74334908
120MP0000537_abnormal_urethra_morphology0.73878673
121MP0003953_abnormal_hormone_level0.73696357
122MP0009703_decreased_birth_body0.73291344
123MP0001270_distended_abdomen0.73061296
124MP0005508_abnormal_skeleton_morphology0.71680879
125MP0002138_abnormal_hepatobiliary_system0.71448183
126MP0002733_abnormal_thermal_nociception0.70467824
127MP0003137_abnormal_impulse_conducting0.70452967
128MP0004808_abnormal_hematopoietic_stem0.69845324
129MP0001765_abnormal_ion_homeostasis0.67959838
130MP0000467_abnormal_esophagus_morphology0.67830990
131MP0004145_abnormal_muscle_electrophysio0.67307434
132MP0000371_diluted_coat_color0.67066899
133MP0005330_cardiomyopathy0.66739900
134MP0000750_abnormal_muscle_regeneration0.65669707
135MP0002086_abnormal_extraembryonic_tissu0.64998126
136MP0008770_decreased_survivor_rate0.64302434
137MP0002108_abnormal_muscle_morphology0.64247127
138MP0003279_aneurysm0.64166109
139MP0002152_abnormal_brain_morphology0.63552420
140MP0000462_abnormal_digestive_system0.63434362
141MP0009931_abnormal_skin_appearance0.62992718
142MP0003942_abnormal_urinary_system0.62957768
143MP0002557_abnormal_social/conspecific_i0.62931176
144MP0003191_abnormal_cellular_cholesterol0.62553264
145MP0005535_abnormal_body_temperature0.62356866
146MP0005595_abnormal_vascular_smooth0.60679117
147MP0003385_abnormal_body_wall0.59431089
148MP0001533_abnormal_skeleton_physiology0.58861227
149MP0000249_abnormal_blood_vessel0.58715565
150MP0000920_abnormal_myelination0.58418538
151MP0003123_paternal_imprinting0.58113765

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.80338970
2Hyperacusis (HP:0010780)3.74257877
3Cerebral aneurysm (HP:0004944)3.57812814
4Macroorchidism (HP:0000053)3.35613852
5Premature rupture of membranes (HP:0001788)3.27464314
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.22365680
7Abnormality of the lower motor neuron (HP:0002366)3.21852867
8Obstructive sleep apnea (HP:0002870)3.15970840
9Insomnia (HP:0100785)3.04815842
10Elfin facies (HP:0004428)2.96230949
11Broad face (HP:0000283)2.93388986
12Visual hallucinations (HP:0002367)2.88987241
13Ulnar bowing (HP:0003031)2.84224612
14Increased connective tissue (HP:0009025)2.72377714
15Distal lower limb amyotrophy (HP:0008944)2.68172574
16Papilledema (HP:0001085)2.60274676
17Neoplasm of the heart (HP:0100544)2.59701325
18Bundle branch block (HP:0011710)2.56968368
19Renovascular hypertension (HP:0100817)2.54247394
20Hypercortisolism (HP:0001578)2.50399005
21Hyperinsulinemic hypoglycemia (HP:0000825)2.48173877
22Lymphangioma (HP:0100764)2.46645434
23Vertebral compression fractures (HP:0002953)2.45275912
24Enlarged penis (HP:0000040)2.41112313
25Renal duplication (HP:0000075)2.39609804
26Disproportionate tall stature (HP:0001519)2.37425065
27Pointed chin (HP:0000307)2.36942292
28Increased variability in muscle fiber diameter (HP:0003557)2.35254576
29Aneurysm (HP:0002617)2.33614295
30Dysmetric saccades (HP:0000641)2.33540784
31Hemiplegia (HP:0002301)2.33514116
32Cerebral inclusion bodies (HP:0100314)2.30753307
33Turricephaly (HP:0000262)2.29232147
34Cervical subluxation (HP:0003308)2.27693047
35Hemorrhage of the eye (HP:0011885)2.25217784
36Achilles tendon contracture (HP:0001771)2.23349326
37Flat acetabular roof (HP:0003180)2.22208610
38Ventricular fibrillation (HP:0001663)2.21589344
39Spinal rigidity (HP:0003306)2.19734858
40Mitral regurgitation (HP:0001653)2.19036457
41Fragile skin (HP:0001030)2.18099627
42Overriding aorta (HP:0002623)2.17829288
43Depression (HP:0000716)2.17493196
44Striae distensae (HP:0001065)2.16751534
45Neurofibrillary tangles (HP:0002185)2.16309096
46Long toe (HP:0010511)2.16034560
47Lower limb amyotrophy (HP:0007210)2.14370742
48Centrally nucleated skeletal muscle fibers (HP:0003687)2.14277158
49Upper limb amyotrophy (HP:0009129)2.13874658
50Distal upper limb amyotrophy (HP:0007149)2.13874658
51Bowel diverticulosis (HP:0005222)2.13832984
52Resting tremor (HP:0002322)2.13817064
53Arterial tortuosity (HP:0005116)2.12430743
54Distal lower limb muscle weakness (HP:0009053)2.10618584
55Supranuclear gaze palsy (HP:0000605)2.10411020
56Shallow orbits (HP:0000586)2.10385778
57Wormian bones (HP:0002645)2.07940413
58Vascular tortuosity (HP:0004948)2.06134745
59Asymmetry of the thorax (HP:0001555)2.05548455
60Atrophic scars (HP:0001075)2.04120606
61Hand muscle atrophy (HP:0009130)2.03658019
62Abnormality of skeletal muscle fiber size (HP:0012084)2.03469753
63Abnormality of the Achilles tendon (HP:0005109)2.02544038
64Blue sclerae (HP:0000592)2.00923294
65Subacute progressive viral hepatitis (HP:0006572)2.00571259
66Broad metatarsal (HP:0001783)2.00086829
67Annular pancreas (HP:0001734)1.99942749
68Abnormality of endocrine pancreas physiology (HP:0012093)1.99564514
69Abnormality of the pancreatic islet cells (HP:0006476)1.99564514
70Ketoacidosis (HP:0001993)1.99438060
71Dilatation of the ascending aorta (HP:0005111)1.98049927
72Deep venous thrombosis (HP:0002625)1.97898937
73Difficulty running (HP:0009046)1.96998837
74Heterotopia (HP:0002282)1.96981078
75Difficulty climbing stairs (HP:0003551)1.96562509
76Hypoglycemic seizures (HP:0002173)1.93127809
77Abnormality of the fingertips (HP:0001211)1.92879203
78Asymmetric septal hypertrophy (HP:0001670)1.91969010
79Biconcave vertebral bodies (HP:0004586)1.91252754
80Abnormality of the distal phalanx of the thumb (HP:0009617)1.90728764
81Aortic aneurysm (HP:0004942)1.90129576
82Abnormality of the astrocytes (HP:0100707)1.90008926
83Astrocytoma (HP:0009592)1.90008926
84Polycythemia (HP:0001901)1.89786037
85Genu recurvatum (HP:0002816)1.89492751
86Agitation (HP:0000713)1.88306360
87Postural instability (HP:0002172)1.87665986
88Mitral valve prolapse (HP:0001634)1.87301133
89Genetic anticipation (HP:0003743)1.86984943
90Stridor (HP:0010307)1.86181218
91Atrioventricular block (HP:0001678)1.85066430
92Long palpebral fissure (HP:0000637)1.84962095
93Action tremor (HP:0002345)1.84950337
94Flat cornea (HP:0007720)1.84466667
95Late onset (HP:0003584)1.84081809
96J-shaped sella turcica (HP:0002680)1.83882127
97Focal seizures (HP:0007359)1.83879821
98Vertebral arch anomaly (HP:0008438)1.82145353
99Bladder diverticulum (HP:0000015)1.82007366
100Hamartoma of the eye (HP:0010568)1.80014939
101Myokymia (HP:0002411)1.79272531
102Abnormal social behavior (HP:0012433)1.77658098
103Impaired social interactions (HP:0000735)1.77658098
104Sudden death (HP:0001699)1.77318832
105Impaired smooth pursuit (HP:0007772)1.76184350
106Rapidly progressive (HP:0003678)1.75721231
107EMG: neuropathic changes (HP:0003445)1.75125989
108Obsessive-compulsive behavior (HP:0000722)1.73847232
109Frequent falls (HP:0002359)1.72520882
110Hyperparathyroidism (HP:0000843)1.72328889
111Interstitial pulmonary disease (HP:0006530)1.71262457
112Advanced eruption of teeth (HP:0006288)1.70119890
113Aortic dissection (HP:0002647)1.69573875
114Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.68829884
115Ankle contracture (HP:0006466)1.68659237
116Urinary glycosaminoglycan excretion (HP:0003541)1.67959700
117Mucopolysacchariduria (HP:0008155)1.67959700
118Arnold-Chiari malformation (HP:0002308)1.67933368
119Germ cell neoplasia (HP:0100728)1.67847692
120Ankyloglossia (HP:0010296)1.67581071
121Cellulitis (HP:0100658)1.67540906
122Joint laxity (HP:0001388)1.67342900
123Abnormality of oral frenula (HP:0000190)1.67153015
124Abnormality of the thoracic spine (HP:0100711)1.65918778
125Sacral dimple (HP:0000960)1.65875028
126Hematochezia (HP:0002573)1.65779245
127Back pain (HP:0003418)1.65278805
128Thin ribs (HP:0000883)1.65037118
129Congenital glaucoma (HP:0001087)1.64709223
130Hyperglycemia (HP:0003074)1.64596998
131Heart block (HP:0012722)1.64206015
132Bronchomalacia (HP:0002780)1.64191584
133Dislocated radial head (HP:0003083)1.63393885
134Pancreatic islet-cell hyperplasia (HP:0004510)1.63290725
135Spinal cord lesions (HP:0100561)1.63027698
136Syringomyelia (HP:0003396)1.63027698
137Large for gestational age (HP:0001520)1.62113579
138Thin bony cortex (HP:0002753)1.61856669
139Abnormality of polysaccharide metabolism (HP:0011012)1.61678560
140Abnormality of glycosaminoglycan metabolism (HP:0004371)1.61678560
141Abnormality of mucopolysaccharide metabolism (HP:0011020)1.61678560
142Hyperextensible skin (HP:0000974)1.61613254
143Patellar dislocation (HP:0002999)1.61476917
144Precocious puberty (HP:0000826)1.60645696
145Neuronal loss in central nervous system (HP:0002529)1.60577977
146Apathy (HP:0000741)1.60402789
147Osteolytic defects of the phalanges of the hand (HP:0009771)1.60193171
148Osteolytic defects of the hand bones (HP:0009699)1.60193171
149Short nail (HP:0001799)1.59343869
150Urinary bladder sphincter dysfunction (HP:0002839)1.59114130
151Ankle clonus (HP:0011448)1.56789127
152Prolonged QT interval (HP:0001657)1.56036197
153Visceral angiomatosis (HP:0100761)1.55830220
154Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.55220582
155Abnormal ossification of hand bones (HP:0005921)1.54924171
156Growth hormone excess (HP:0000845)1.54388517
157Onion bulb formation (HP:0003383)1.54357194
158Hammertoe (HP:0001765)1.54187424
159Esophageal varix (HP:0002040)1.54183287
160Dysostosis multiplex (HP:0000943)1.53804458
161Persistence of primary teeth (HP:0006335)1.53484242
162Polygenic inheritance (HP:0010982)1.53432557
163Segmental peripheral demyelination/remyelination (HP:0003481)1.53340212
164Amyotrophic lateral sclerosis (HP:0007354)1.53136396
165Mildly elevated creatine phosphokinase (HP:0008180)1.52891308
166Venous abnormality (HP:0002624)1.52857511
167Hemangiomatosis (HP:0007461)1.52737976
168Premature skin wrinkling (HP:0100678)1.52302966
169Hepatoblastoma (HP:0002884)1.52053944
170Ependymoma (HP:0002888)1.51881802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.06087971
2PKN23.06367740
3SMG13.03653525
4PRPF4B3.00744223
5MAP3K102.75217787
6RIPK12.74800312
7PRKD32.68961886
8MAP3K92.13295358
9IRAK32.06866041
10PDGFRA2.04919193
11EEF2K1.95061264
12PTK61.88399196
13ICK1.78891604
14ERN11.77731512
15CAMKK11.72846279
16SIK21.72308055
17DAPK21.69381681
18TAOK11.66127328
19INSRR1.59331506
20CAMK1G1.56802003
21ALK1.56157328
22PRKCH1.55165809
23CDK121.53451135
24MARK11.51026248
25NTRK31.47458492
26KSR21.46474710
27TYRO31.45999215
28PAK61.44032528
29HIPK21.39234350
30SIK11.36900833
31EPHA21.34385387
32MAP2K31.34152832
33PRKD21.30192201
34CAMK1D1.29167779
35MAP3K21.24900595
36RET1.24274818
37STK381.22883587
38MAP3K71.22626076
39TTN1.21033241
40MARK21.19079868
41NTRK11.18069942
42CDC42BPA1.16136810
43UHMK11.11127509
44NTRK21.10009337
45MAP3K111.08959820
46SGK31.06807584
47TESK11.06712065
48MTOR1.05386661
49MAP3K11.03616448
50DMPK1.02750796
51TAOK31.02107973
52SCYL21.01763013
53MST1R0.97753982
54PAK40.96235012
55FGFR40.92026208
56PHKG10.91874100
57PHKG20.91874100
58LMTK20.91788316
59MAP3K60.89854530
60TAOK20.88409080
61JAK10.85942689
62PASK0.84712108
63DYRK1B0.83536072
64RIPK40.83078099
65PTK20.83006671
66STK110.82338087
67MAP3K30.82184572
68MAP3K40.80872484
69PDGFRB0.79395347
70BMX0.79325159
71ARAF0.78375080
72MAP4K10.77971531
73MAPK150.77862378
74FGFR30.77673431
75MINK10.77519534
76KDR0.75456471
77JAK20.75335346
78RPS6KA20.75086131
79TGFBR20.74591514
80PRKD10.74462390
81CDK50.73919162
82DDR20.73916148
83PRKAA10.68144556
84RPS6KL10.67577181
85RPS6KC10.67577181
86TIE10.67181661
87WNK10.66315799
88MAPK120.65145799
89PAK30.64236595
90MAPK110.63737707
91KSR10.63549561
92DAPK10.63342411
93LATS20.63065574
94CAMK40.62962745
95ZAP700.61129200
96CDK60.60953514
97PRKG20.60485825
98FGFR20.59487776
99PDK10.56064344
100MET0.54603958
101NME20.53632230
102MAP3K130.52358693
103EPHA40.51090743
104CAMKK20.50548860
105EPHB10.50395302
106IRAK20.50385007
107MAP2K20.50217586
108PDPK10.49865013
109MAP2K40.48391910
110MAP3K80.47079008
111FES0.46881143
112TYK20.46208141
113BRD40.44742329
114TBK10.44656227
115SGK20.44139711
116RPS6KA60.43142221
117RPS6KA30.42921171
118BRAF0.42343640
119CDK40.42259360
120CAMK10.42133889
121RPS6KB20.40913775
122EPHB20.40542016
123TESK20.40267481
124SGK10.40144483
125GRK60.39709857
126PAK20.39603274
127MAPK100.39418212
128HCK0.38154184
129LRRK20.36862981
130ERBB20.36466487
131NEK90.34862106
132MAP3K140.34837126
133MAPKAPK30.34531811
134FER0.34360737
135AKT20.34256369
136FYN0.34026940
137CSK0.32884110
138LATS10.32348541
139MAPK80.32089432

Predicted pathways (KEGG)

RankGene SetZ-score
1Type II diabetes mellitus_Homo sapiens_hsa049302.15188477
2Other glycan degradation_Homo sapiens_hsa005112.11782088
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.01843202
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00824623
5Insulin secretion_Homo sapiens_hsa049111.90752635
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.82256263
7Nitrogen metabolism_Homo sapiens_hsa009101.80373983
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65663099
9Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64024622
10mTOR signaling pathway_Homo sapiens_hsa041501.53455671
11Carbohydrate digestion and absorption_Homo sapiens_hsa049731.50058899
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.42880654
13Long-term potentiation_Homo sapiens_hsa047201.40980117
14Olfactory transduction_Homo sapiens_hsa047401.40746479
15Circadian entrainment_Homo sapiens_hsa047131.37883857
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37531110
17Estrogen signaling pathway_Homo sapiens_hsa049151.35621016
18Lysine degradation_Homo sapiens_hsa003101.32797868
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29943233
20Dorso-ventral axis formation_Homo sapiens_hsa043201.29525789
21Glioma_Homo sapiens_hsa052141.28688467
22Endometrial cancer_Homo sapiens_hsa052131.27170384
23Gastric acid secretion_Homo sapiens_hsa049711.25469324
24Thyroid hormone signaling pathway_Homo sapiens_hsa049191.25309026
25Insulin resistance_Homo sapiens_hsa049311.24051981
26Longevity regulating pathway - mammal_Homo sapiens_hsa042111.23814000
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23260855
28Chronic myeloid leukemia_Homo sapiens_hsa052201.21956207
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.20035862
30Cholinergic synapse_Homo sapiens_hsa047251.19761896
31ECM-receptor interaction_Homo sapiens_hsa045121.18571063
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18044942
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14172794
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.13140219
35Amoebiasis_Homo sapiens_hsa051461.12655590
36Insulin signaling pathway_Homo sapiens_hsa049101.11251540
37GnRH signaling pathway_Homo sapiens_hsa049121.11184227
38Salivary secretion_Homo sapiens_hsa049701.08897464
39Cocaine addiction_Homo sapiens_hsa050301.08777079
40Renin secretion_Homo sapiens_hsa049241.08758577
41Glutamatergic synapse_Homo sapiens_hsa047241.08303626
42Glucagon signaling pathway_Homo sapiens_hsa049221.08061889
43Synaptic vesicle cycle_Homo sapiens_hsa047211.07906054
44Morphine addiction_Homo sapiens_hsa050321.07723086
45Non-small cell lung cancer_Homo sapiens_hsa052231.07405393
46Dopaminergic synapse_Homo sapiens_hsa047281.07394665
47GABAergic synapse_Homo sapiens_hsa047271.07055766
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06845868
49Thyroid cancer_Homo sapiens_hsa052161.06477945
50Amphetamine addiction_Homo sapiens_hsa050311.04448624
51Dilated cardiomyopathy_Homo sapiens_hsa054141.04295843
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.02662559
53Oxytocin signaling pathway_Homo sapiens_hsa049211.01251984
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01204476
55Gap junction_Homo sapiens_hsa045401.00200803
56Small cell lung cancer_Homo sapiens_hsa052220.99377668
57VEGF signaling pathway_Homo sapiens_hsa043700.99270825
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97425918
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.97171826
60Fructose and mannose metabolism_Homo sapiens_hsa000510.95805295
61Bile secretion_Homo sapiens_hsa049760.94257264
62cAMP signaling pathway_Homo sapiens_hsa040240.93326329
63Prolactin signaling pathway_Homo sapiens_hsa049170.91767182
64Notch signaling pathway_Homo sapiens_hsa043300.89915880
65MicroRNAs in cancer_Homo sapiens_hsa052060.89157090
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.86717229
67Osteoclast differentiation_Homo sapiens_hsa043800.86152115
68AMPK signaling pathway_Homo sapiens_hsa041520.85909000
69Pentose phosphate pathway_Homo sapiens_hsa000300.85831009
70ErbB signaling pathway_Homo sapiens_hsa040120.84919807
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.83962217
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83695867
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.83667379
74Prostate cancer_Homo sapiens_hsa052150.83583517
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83291120
76Focal adhesion_Homo sapiens_hsa045100.82921639
77Colorectal cancer_Homo sapiens_hsa052100.82911353
78Pancreatic secretion_Homo sapiens_hsa049720.81551148
79Hepatitis C_Homo sapiens_hsa051600.81374221
80Melanogenesis_Homo sapiens_hsa049160.80652555
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80286366
82Acute myeloid leukemia_Homo sapiens_hsa052210.79866364
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.79499031
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78963059
85Thyroid hormone synthesis_Homo sapiens_hsa049180.78947761
86Lysosome_Homo sapiens_hsa041420.76258332
87HIF-1 signaling pathway_Homo sapiens_hsa040660.76225862
88B cell receptor signaling pathway_Homo sapiens_hsa046620.76106145
89Hepatitis B_Homo sapiens_hsa051610.75612571
90Endocytosis_Homo sapiens_hsa041440.75462302
91Toxoplasmosis_Homo sapiens_hsa051450.75138758
92Platelet activation_Homo sapiens_hsa046110.75119621
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74675010
94TNF signaling pathway_Homo sapiens_hsa046680.74277112
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74268642
96Proteoglycans in cancer_Homo sapiens_hsa052050.73817513
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73786608
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73567437
99Galactose metabolism_Homo sapiens_hsa000520.73110290
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72933357
101Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72644646
102Renal cell carcinoma_Homo sapiens_hsa052110.71854730
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71148039
104Rap1 signaling pathway_Homo sapiens_hsa040150.70810423
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70809900
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69935989
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.69259811
108Vibrio cholerae infection_Homo sapiens_hsa051100.69010001
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68726812
110Choline metabolism in cancer_Homo sapiens_hsa052310.68549960
111Apoptosis_Homo sapiens_hsa042100.66385593
112Pancreatic cancer_Homo sapiens_hsa052120.65717962
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65338799
114Taste transduction_Homo sapiens_hsa047420.64293193
115Salmonella infection_Homo sapiens_hsa051320.64090456
116Inositol phosphate metabolism_Homo sapiens_hsa005620.62432999
117Calcium signaling pathway_Homo sapiens_hsa040200.61601854
118Adherens junction_Homo sapiens_hsa045200.61419054
119Chemokine signaling pathway_Homo sapiens_hsa040620.61069645
120Prion diseases_Homo sapiens_hsa050200.60990857
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60872770
122* MAPK signaling pathway_Homo sapiens_hsa040100.59948740
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59581873
124ABC transporters_Homo sapiens_hsa020100.58926441
125Long-term depression_Homo sapiens_hsa047300.58229135
126Bladder cancer_Homo sapiens_hsa052190.56395787
127Arginine biosynthesis_Homo sapiens_hsa002200.55406764
128Viral carcinogenesis_Homo sapiens_hsa052030.55364040
129FoxO signaling pathway_Homo sapiens_hsa040680.55177656
130Influenza A_Homo sapiens_hsa051640.54923574
131Shigellosis_Homo sapiens_hsa051310.54727328
132Axon guidance_Homo sapiens_hsa043600.54247377
133HTLV-I infection_Homo sapiens_hsa051660.52974060
134Pathways in cancer_Homo sapiens_hsa052000.52495947

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