TANK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.61175349
2neutrophil activation involved in immune response (GO:0002283)5.58391403
3response to peptidoglycan (GO:0032494)4.75127886
4NIK/NF-kappaB signaling (GO:0038061)4.63021780
5positive regulation of interferon-alpha production (GO:0032727)4.55843105
6regulation of interferon-alpha production (GO:0032647)4.38638337
7negative regulation of interleukin-12 production (GO:0032695)4.32730479
8natural killer cell mediated immunity (GO:0002228)4.31641183
9natural killer cell mediated cytotoxicity (GO:0042267)4.31641183
10regulation of B cell receptor signaling pathway (GO:0050855)4.28364280
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.23115217
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.23115217
13modulation by symbiont of host immune response (GO:0052553)4.23115217
14positive regulation by symbiont of host defense response (GO:0052509)4.23115217
15modulation by symbiont of host defense response (GO:0052031)4.23115217
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.23115217
17regulation of T-helper 1 cell differentiation (GO:0045625)4.15182863
18positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.14607922
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.13350612
20granulocyte activation (GO:0036230)4.12734252
21neutrophil activation (GO:0042119)4.05146379
22positive regulation of heat generation (GO:0031652)3.95305828
23regulation of activation of Janus kinase activity (GO:0010533)3.93962971
24regulation of T cell tolerance induction (GO:0002664)3.92558291
25regulation of dendritic cell antigen processing and presentation (GO:0002604)3.92027953
26regulation of RIG-I signaling pathway (GO:0039535)3.89946442
27positive regulation of natural killer cell differentiation (GO:0032825)3.88505805
28respiratory burst (GO:0045730)3.86657708
29positive regulation of interleukin-12 production (GO:0032735)3.85582355
30antigen processing and presentation of endogenous antigen (GO:0019883)3.83725073
31lipopolysaccharide-mediated signaling pathway (GO:0031663)3.81247284
32regulation of fever generation (GO:0031620)3.80608541
33response to muramyl dipeptide (GO:0032495)3.79695096
34type I interferon signaling pathway (GO:0060337)3.79136321
35cellular response to type I interferon (GO:0071357)3.79136321
36activated T cell proliferation (GO:0050798)3.76174144
37response to type I interferon (GO:0034340)3.76007219
38myeloid dendritic cell differentiation (GO:0043011)3.75591137
39regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.68718406
40immunoglobulin mediated immune response (GO:0016064)3.66803209
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.65593913
42positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.65430923
43cellular response to interferon-beta (GO:0035458)3.64525003
44response to interleukin-15 (GO:0070672)3.61558782
45regulation of chronic inflammatory response (GO:0002676)3.60205323
46positive regulation of gamma-delta T cell activation (GO:0046645)3.59612825
47regulation of interleukin-12 biosynthetic process (GO:0045075)3.59543775
48positive regulation of antigen processing and presentation (GO:0002579)3.57079713
49positive regulation of tolerance induction (GO:0002645)3.56622188
50cellular response to zinc ion (GO:0071294)3.54169465
51negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.53761525
52negative regulation of cell killing (GO:0031342)3.53761525
53cellular response to interleukin-15 (GO:0071350)3.53591054
54regulation of tolerance induction (GO:0002643)3.53290382
55regulation of gamma-delta T cell activation (GO:0046643)3.52275973
56myeloid dendritic cell activation (GO:0001773)3.51960159
57negative T cell selection (GO:0043383)3.50792093
58hydrogen peroxide biosynthetic process (GO:0050665)3.49975015
59detection of molecule of bacterial origin (GO:0032490)3.47699153
60leukocyte aggregation (GO:0070486)3.45562968
61cellular response to exogenous dsRNA (GO:0071360)3.45084948
62positive regulation of T-helper cell differentiation (GO:0045624)3.42975480
63defense response to protozoan (GO:0042832)3.42189831
64positive regulation of alpha-beta T cell proliferation (GO:0046641)3.40882755
65macrophage activation involved in immune response (GO:0002281)3.40471611
66regulation of regulatory T cell differentiation (GO:0045589)3.39156199
67positive regulation of chemokine biosynthetic process (GO:0045080)3.38758375
68leukocyte mediated cytotoxicity (GO:0001909)3.38671976
69positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.36496720
70positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.35308909
71interferon-gamma-mediated signaling pathway (GO:0060333)3.34907029
72regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.34278478
73cytidine metabolic process (GO:0046087)3.33750941
74cytidine catabolic process (GO:0006216)3.33750941
75cytidine deamination (GO:0009972)3.33750941
76antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.32596200
77antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.32596200
78positive regulation of interferon-beta production (GO:0032728)3.30961444
79positive regulation of interleukin-2 production (GO:0032743)3.30585011
80regulation of alpha-beta T cell proliferation (GO:0046640)3.28747276
81reactive oxygen species biosynthetic process (GO:1903409)3.28050634
82regulation of lymphocyte chemotaxis (GO:1901623)3.27212812
83T cell migration (GO:0072678)3.27206284
84superoxide anion generation (GO:0042554)3.25924974
85positive regulation of natural killer cell mediated immunity (GO:0002717)3.25365902
86T-helper 1 type immune response (GO:0042088)3.24808387
87positive regulation of type 2 immune response (GO:0002830)3.24037387
88regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.23960788
89regulation of chemokine biosynthetic process (GO:0045073)3.22946964
90positive regulation of interleukin-17 production (GO:0032740)3.21160377
91regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.21066662
92regulation of natural killer cell mediated immunity (GO:0002715)3.21066662
93negative thymic T cell selection (GO:0045060)3.19506740
94necroptotic process (GO:0070266)3.18442487
95negative regulation of viral genome replication (GO:0045071)3.18372869
96myeloid cell activation involved in immune response (GO:0002275)3.17840492
97regulation of interferon-beta biosynthetic process (GO:0045357)3.17600781
98positive regulation of T-helper 1 type immune response (GO:0002827)3.17444908
99positive regulation of monocyte chemotaxis (GO:0090026)3.16419813
100positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.16211597
101eosinophil chemotaxis (GO:0048245)3.14815466
102negative regulation of interleukin-17 production (GO:0032700)3.14619652
103dendritic cell differentiation (GO:0097028)3.14453233
104regulation of antigen processing and presentation (GO:0002577)3.13720395
105regulation of interleukin-12 production (GO:0032655)3.13665678
106negative regulation of T cell mediated immunity (GO:0002710)3.13154765
107response to interferon-beta (GO:0035456)3.13122101
108regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.11125526
109regulation of gamma-delta T cell differentiation (GO:0045586)3.09622198
110positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.08098388
111cytokine secretion (GO:0050663)3.08056755
112regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.07986461
113positive regulation of defense response to virus by host (GO:0002230)3.07886499
114pyrimidine ribonucleoside catabolic process (GO:0046133)3.07373138
115regulation of interleukin-17 production (GO:0032660)3.07058537
116positive regulation of interleukin-1 beta secretion (GO:0050718)3.04801160
117monocyte chemotaxis (GO:0002548)3.03814952
118positive regulation of B cell differentiation (GO:0045579)3.00586736
119positive regulation of cellular amide metabolic process (GO:0034250)2.98109042
120cellular extravasation (GO:0045123)2.97765107
121response to protozoan (GO:0001562)2.97382112
122response to interferon-alpha (GO:0035455)2.97227923
123regulation of hypersensitivity (GO:0002883)2.97092320
124positive regulation of lymphocyte migration (GO:2000403)2.96925081
125regulation of interleukin-1 beta secretion (GO:0050706)2.95024381
126response to host immune response (GO:0052572)2.94919553
127response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.94919553
128positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.94830232
129positive regulation of NF-kappaB import into nucleus (GO:0042346)2.94160921
130regulation of T-helper cell differentiation (GO:0045622)2.93941200
131lymphocyte chemotaxis (GO:0048247)2.92958648
132positive regulation of interleukin-10 production (GO:0032733)2.92446781
133regulation of T-helper 1 type immune response (GO:0002825)2.91129632
134regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.89127269
135positive regulation of T cell cytokine production (GO:0002726)2.88807971
136production of molecular mediator involved in inflammatory response (GO:0002532)2.87982861
137regulation of heat generation (GO:0031650)2.87944861
138B cell mediated immunity (GO:0019724)2.87825526
139regulation of B cell differentiation (GO:0045577)2.87540652
140positive regulation of cytokine biosynthetic process (GO:0042108)2.87413886
141positive regulation of interleukin-1 secretion (GO:0050716)2.86532928
142negative regulation of T-helper cell differentiation (GO:0045623)2.85128853
143negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.85128853
144regulation of leukocyte mediated cytotoxicity (GO:0001910)2.83742587
145DNA deamination (GO:0045006)2.82863576
146positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.82857731
147detection of biotic stimulus (GO:0009595)2.81915067
148programmed necrotic cell death (GO:0097300)2.81692944
149microglial cell activation (GO:0001774)2.81588881
150regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.81437410
151regulation of T cell chemotaxis (GO:0010819)2.80713065
152positive regulation of T cell chemotaxis (GO:0010820)2.80713065
153positive regulation of humoral immune response (GO:0002922)2.78292663
154dendritic cell migration (GO:0036336)2.73341362
155interferon-gamma production (GO:0032609)2.72935081

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.57739324
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.64849549
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.63440887
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.13626146
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.03411566
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.64392043
7IRF8_27001747_Chip-Seq_BMDM_Mouse4.15883017
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.68182541
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.60609347
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.43956689
11* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.27158928
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.18112761
13* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.17711761
14* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.04894514
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.95989432
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.94179719
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.90688798
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.59743383
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.21448442
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.02258817
21* SPI1_23547873_ChIP-Seq_NB4_Human2.00482762
22MYB_26560356_Chip-Seq_TH2_Human2.00386277
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.96666400
24* RUNX_20019798_ChIP-Seq_JUKART_Human1.91486636
25GATA1_22025678_ChIP-Seq_K562_Human1.91081740
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84980700
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83421859
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82504817
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79648282
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77862327
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71862475
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71060375
33PU_27001747_Chip-Seq_BMDM_Mouse1.70453390
34* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65354330
35VDR_24787735_ChIP-Seq_THP-1_Human1.63951235
36PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.61663635
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60776575
38* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59572612
39CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52566543
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.51241472
41VDR_24763502_ChIP-Seq_THP-1_Human1.49728075
42CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48328419
43MYB_26560356_Chip-Seq_TH1_Human1.45992365
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45867587
45SCL_19346495_ChIP-Seq_HPC-7_Human1.44294225
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40335702
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38713596
48MAF_26560356_Chip-Seq_TH1_Human1.38123147
49* GATA3_26560356_Chip-Seq_TH2_Human1.37547868
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37502058
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35344312
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.34561007
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.33435156
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32780921
55GATA3_27048872_Chip-Seq_THYMUS_Human1.31655370
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30817888
57CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30450535
58SPI1_23127762_ChIP-Seq_K562_Human1.29547958
59CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28284972
60* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26769806
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.22928157
62* ER_23166858_ChIP-Seq_MCF-7_Human1.18677056
63VDR_23849224_ChIP-Seq_CD4+_Human1.16357016
64* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15966431
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15501476
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14757475
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13623894
68ZNF274_21170338_ChIP-Seq_K562_Hela1.13518190
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10491514
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.09313378
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07646059
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06833548
73* IGF1R_20145208_ChIP-Seq_DFB_Human1.05198140
74* GABP_17652178_ChIP-ChIP_JURKAT_Human1.04751301
75* SALL4_22934838_ChIP-ChIP_CD34+_Human1.04400981
76* VDR_22108803_ChIP-Seq_LS180_Human1.04261680
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.03956105
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03772659
79NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01113302
80TAF15_26573619_Chip-Seq_HEK293_Human0.99280078
81OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98879874
82NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98057857
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98057857
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97973043
85* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97859614
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96550099
87SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96498901
88* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94954958
89P300_19829295_ChIP-Seq_ESCs_Human0.94293674
90* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93313750
91* CMYC_18555785_Chip-Seq_ESCs_Mouse0.92345116
92* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91983679
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91837588
94* NANOG_18555785_Chip-Seq_ESCs_Mouse0.91338706
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90650901
96PRDM14_20953172_ChIP-Seq_ESCs_Human0.89585963
97CDX2_22108803_ChIP-Seq_LS180_Human0.89388308
98* E2F1_18555785_Chip-Seq_ESCs_Mouse0.89181284
99GATA3_26560356_Chip-Seq_TH1_Human0.87874585
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87550882
101OCT4_18555785_Chip-Seq_ESCs_Mouse0.87469321
102* P53_22387025_ChIP-Seq_ESCs_Mouse0.85446348
103VDR_21846776_ChIP-Seq_THP-1_Human0.85050687
104* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84928208
105* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.84868820
106* P300_18555785_Chip-Seq_ESCs_Mouse0.84713600
107* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84699281
108THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84535883
109EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84257260
110FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83919089
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83741030
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83670540
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83200840
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83194619
115* NMYC_18555785_Chip-Seq_ESCs_Mouse0.83101744
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82895726
117* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.81776314
118UTX_26944678_Chip-Seq_JUKART_Human0.81622254
119* SOX2_20726797_ChIP-Seq_SW620_Human0.77976225
120SMRT_27268052_Chip-Seq_Bcells_Human0.76279095
121SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.75439855
122SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.75439855
123PU.1_20513432_ChIP-Seq_Bcells_Mouse0.73288973
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73243660
125ELK1_19687146_ChIP-ChIP_HELA_Human0.73105077
126EGR1_19032775_ChIP-ChIP_M12_Human0.72143422
127HOXB4_20404135_ChIP-ChIP_EML_Mouse0.71981503
128NOTCH1_21737748_ChIP-Seq_TLL_Human0.70615536
129TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.68724321
130* CJUN_26792858_Chip-Seq_BT549_Human0.67942360
131SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.67641517
132* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67457840
133MAF_26560356_Chip-Seq_TH2_Human0.67365947
134IKZF1_21737484_ChIP-ChIP_HCT116_Human0.67127339
135RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.67097432
136GATA1_22383799_ChIP-Seq_G1ME_Mouse0.66379424
137* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.64622228
138TFEB_21752829_ChIP-Seq_HELA_Human0.63492997
139PCGF2_27294783_Chip-Seq_ESCs_Mouse0.62685483
140FLI1_27457419_Chip-Seq_LIVER_Mouse0.62190034
141* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.61701110
142TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.61392556
143ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.60643939
144ELF1_17652178_ChIP-ChIP_JURKAT_Human0.59998543

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.02851734
2MP0009785_altered_susceptibility_to4.21071200
3MP0002148_abnormal_hypersensitivity_rea3.86339807
4MP0000685_abnormal_immune_system3.53594880
5MP0003436_decreased_susceptibility_to3.52666074
6* MP0005000_abnormal_immune_tolerance3.31937537
7MP0005387_immune_system_phenotype3.11395783
8MP0001790_abnormal_immune_system3.11395783
9MP0005671_abnormal_response_to3.09097852
10MP0005025_abnormal_response_to3.06333714
11* MP0002419_abnormal_innate_immunity3.05907565
12MP0003724_increased_susceptibility_to3.03314801
13MP0006082_CNS_inflammation2.95683714
14* MP0001800_abnormal_humoral_immune2.80218936
15* MP0002452_abnormal_antigen_presenting2.77729293
16* MP0002723_abnormal_immune_serum2.67582738
17MP0004510_myositis2.59615685
18MP0003303_peritoneal_inflammation2.44537958
19* MP0001819_abnormal_immune_cell2.41445465
20MP0002006_tumorigenesis2.39387985
21* MP0002420_abnormal_adaptive_immunity2.38091271
22MP0001853_heart_inflammation2.23690211
23MP0002254_reproductive_system_inflammat2.10665601
24MP0009764_decreased_sensitivity_to1.97220095
25MP0004947_skin_inflammation1.95414607
26MP0005310_abnormal_salivary_gland1.95250340
27MP0001533_abnormal_skeleton_physiology1.92320025
28MP0002138_abnormal_hepatobiliary_system1.90842982
29* MP0001845_abnormal_inflammatory_respons1.90104993
30MP0005464_abnormal_platelet_physiology1.87407754
31* MP0002405_respiratory_system_inflammati1.86277872
32MP0002166_altered_tumor_susceptibility1.83227935
33* MP0000716_abnormal_immune_system1.75230655
34MP0009333_abnormal_splenocyte_physiolog1.72678674
35MP0003448_altered_tumor_morphology1.72005902
36MP0010155_abnormal_intestine_physiology1.71774794
37* MP0002398_abnormal_bone_marrow1.68721501
38MP0000569_abnormal_digit_pigmentation1.66437974
39MP0008469_abnormal_protein_level1.66202431
40MP0005058_abnormal_lysosome_morphology1.66074259
41MP0003763_abnormal_thymus_physiology1.54231567
42MP0000858_altered_metastatic_potential1.46999380
43MP0002277_abnormal_respiratory_mucosa1.46044698
44MP0003172_abnormal_lysosome_physiology1.38392245
45* MP0002429_abnormal_blood_cell1.37634015
46MP0001348_abnormal_lacrimal_gland1.32879785
47MP0001545_abnormal_hematopoietic_system1.32497095
48MP0005397_hematopoietic_system_phenotyp1.32497095
49MP0005451_abnormal_body_composition1.31613596
50MP0000465_gastrointestinal_hemorrhage1.31338220
51MP0002998_abnormal_bone_remodeling1.27932054
52MP0003075_altered_response_to1.27290515
53* MP0000689_abnormal_spleen_morphology1.27129195
54MP0000343_altered_response_to1.26047604
55MP0003195_calcinosis1.26018833
56MP0001873_stomach_inflammation1.25243511
57* MP0002722_abnormal_immune_system1.22500972
58MP0005084_abnormal_gallbladder_morpholo1.22000709
59MP0004782_abnormal_surfactant_physiolog1.21135782
60MP0003186_abnormal_redox_activity1.14478414
61MP0003300_gastrointestinal_ulcer1.12501661
62MP0009278_abnormal_bone_marrow1.12485392
63MP0002163_abnormal_gland_morphology1.12127298
64MP0003045_fibrosis1.09991863
65MP0004883_abnormal_blood_vessel1.05019725
66MP0002332_abnormal_exercise_endurance1.03918740
67MP0003950_abnormal_plasma_membrane1.01354733
68MP0003252_abnormal_bile_duct0.99470107
69MP0000604_amyloidosis0.98455686
70MP0009763_increased_sensitivity_to0.97876112
71MP0003806_abnormal_nucleotide_metabolis0.95294083
72MP0002933_joint_inflammation0.94797535
73MP0003011_delayed_dark_adaptation0.94754796
74MP0005164_abnormal_response_to0.93074144
75MP0005379_endocrine/exocrine_gland_phen0.92247537
76MP0005166_decreased_susceptibility_to0.91004593
77MP0003183_abnormal_peptide_metabolism0.90677445
78MP0005390_skeleton_phenotype0.89701228
79MP0003191_abnormal_cellular_cholesterol0.87027628
80MP0005167_abnormal_blood-brain_barrier0.84698624
81MP0003453_abnormal_keratinocyte_physiol0.83827433
82MP0005174_abnormal_tail_pigmentation0.83226503
83MP0002396_abnormal_hematopoietic_system0.81860908
84MP0001851_eye_inflammation0.78571154
85MP0003828_pulmonary_edema0.78105582
86MP0001346_abnormal_lacrimal_gland0.76388898
87MP0000703_abnormal_thymus_morphology0.75764049
88MP0005076_abnormal_cell_differentiation0.75210007
89MP0010352_gastrointestinal_tract_polyps0.75085002
90MP0002877_abnormal_melanocyte_morpholog0.74820570
91MP0008057_abnormal_DNA_replication0.74476385
92MP0001881_abnormal_mammary_gland0.73040802
93MP0003690_abnormal_glial_cell0.72287997
94MP0005645_abnormal_hypothalamus_physiol0.71445552
95MP0003091_abnormal_cell_migration0.71329475
96MP0000249_abnormal_blood_vessel0.71138735
97MP0006054_spinal_hemorrhage0.69755300
98MP0000371_diluted_coat_color0.69491225
99MP0003656_abnormal_erythrocyte_physiolo0.67713146
100MP0004381_abnormal_hair_follicle0.67435093
101MP0003221_abnormal_cardiomyocyte_apopto0.66221254
102MP0010307_abnormal_tumor_latency0.65968305
103MP0003866_abnormal_defecation0.64236960
104MP0003566_abnormal_cell_adhesion0.62804207
105MP0000015_abnormal_ear_pigmentation0.61870020
106MP0002132_abnormal_respiratory_system0.61599356
107MP0000490_abnormal_crypts_of0.61422147
108MP0009765_abnormal_xenobiotic_induced0.60935391
109MP0002139_abnormal_hepatobiliary_system0.60020765
110MP0002693_abnormal_pancreas_physiology0.59740158
111MP0005376_homeostasis/metabolism_phenot0.59227449
112MP0002009_preneoplasia0.58470455
113MP0003795_abnormal_bone_structure0.58038946
114MP0000372_irregular_coat_pigmentation0.57628733
115MP0001764_abnormal_homeostasis0.56738452
116MP0008873_increased_physiological_sensi0.56673149
117MP0001663_abnormal_digestive_system0.55914762
118MP0000427_abnormal_hair_cycle0.55594159
119MP0004808_abnormal_hematopoietic_stem0.55580565
120MP0000627_abnormal_mammary_gland0.54634327
121MP0005075_abnormal_melanosome_morpholog0.53791361
122MP0008260_abnormal_autophagy0.53669360
123* MP0000609_abnormal_liver_physiology0.53044526
124* MP0002136_abnormal_kidney_physiology0.52597266
125MP0002876_abnormal_thyroid_physiology0.49446055

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.06424055
2Eczematoid dermatitis (HP:0000976)7.02014896
3Recurrent bacterial skin infections (HP:0005406)6.70182917
4Recurrent gram-negative bacterial infections (HP:0005420)5.35343961
5Mediastinal lymphadenopathy (HP:0100721)5.17820004
6Retrobulbar optic neuritis (HP:0100654)5.10090042
7Optic neuritis (HP:0100653)5.10090042
8Orchitis (HP:0100796)4.95271145
9Myositis (HP:0100614)4.93988110
10Elevated erythrocyte sedimentation rate (HP:0003565)4.93511486
11Autoimmune thrombocytopenia (HP:0001973)4.44949790
12Recurrent skin infections (HP:0001581)4.41804086
13Recurrent fungal infections (HP:0002841)4.37798907
14Abnormality of macrophages (HP:0004311)4.37669597
15Vasculitis (HP:0002633)4.23794592
16Increased IgM level (HP:0003496)4.17486916
17Stomatitis (HP:0010280)3.92729803
18Gingivitis (HP:0000230)3.91918091
19Recurrent viral infections (HP:0004429)3.79617446
20Chronic mucocutaneous candidiasis (HP:0002728)3.63072224
21Recurrent cutaneous fungal infections (HP:0011370)3.63072224
22Chronic obstructive pulmonary disease (HP:0006510)3.57016959
23Obstructive lung disease (HP:0006536)3.57016959
24Pulmonary infiltrates (HP:0002113)3.41973840
25Periodontitis (HP:0000704)3.29327417
26Basal ganglia calcification (HP:0002135)3.26249721
27Vacuolated lymphocytes (HP:0001922)3.25704172
28Recurrent pneumonia (HP:0006532)3.17226114
29Meningitis (HP:0001287)3.10219846
30Keratoconjunctivitis sicca (HP:0001097)3.09182567
31Hypergammaglobulinemia (HP:0010702)3.04907969
32Cellulitis (HP:0100658)3.02938899
33Keratoconjunctivitis (HP:0001096)3.01464030
34Gastrointestinal infarctions (HP:0005244)2.96535271
35Abnormality of T cell number (HP:0011839)2.96369499
36Arterial thrombosis (HP:0004420)2.95886346
37Pustule (HP:0200039)2.92506556
38Tetraparesis (HP:0002273)2.86167364
39Hemoptysis (HP:0002105)2.84006401
40Chronic otitis media (HP:0000389)2.83587055
41Leukocytosis (HP:0001974)2.78439684
42Recurrent lower respiratory tract infections (HP:0002783)2.77421887
43Urticaria (HP:0001025)2.76152518
44Eosinophilia (HP:0001880)2.75964534
45Interstitial pulmonary disease (HP:0006530)2.75409172
46Prostate neoplasm (HP:0100787)2.75247509
47Systemic lupus erythematosus (HP:0002725)2.73217232
48Autoimmune hemolytic anemia (HP:0001890)2.72958108
49Thick nail (HP:0001805)2.70463160
50Osteomyelitis (HP:0002754)2.62935568
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.62295640
52Agammaglobulinemia (HP:0004432)2.53816578
53Keratitis (HP:0000491)2.50257750
54T lymphocytopenia (HP:0005403)2.50005573
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.49530667
56Abnormality of liposaccharide metabolism (HP:0010968)2.47478824
57Abnormality of glycosphingolipid metabolism (HP:0004343)2.47478824
58Abnormality of glycolipid metabolism (HP:0010969)2.47478824
59Fatigue (HP:0012378)2.45064031
60Gangrene (HP:0100758)2.44276219
61Polyneuropathy (HP:0001271)2.43476406
62Chest pain (HP:0100749)2.43438886
63Pulmonary embolism (HP:0002204)2.39561899
64Gastrointestinal stroma tumor (HP:0100723)2.37874827
65Thrombocytosis (HP:0001894)2.37493729
66Premature loss of primary teeth (HP:0006323)2.35927953
67IgA deficiency (HP:0002720)2.35660633
68Increased cerebral lipofuscin (HP:0011813)2.34785495
69Abnormality of eosinophils (HP:0001879)2.33284721
70Joint swelling (HP:0001386)2.33165809
71Myocardial infarction (HP:0001658)2.32727317
72Abnormality of T cells (HP:0002843)2.31567730
73Abnormality of B cell number (HP:0010975)2.29293123
74Severe combined immunodeficiency (HP:0004430)2.29123997
75Gingival bleeding (HP:0000225)2.29088428
76Vertebral compression fractures (HP:0002953)2.28352954
77Axonal loss (HP:0003447)2.28133751
78Encephalitis (HP:0002383)2.27905350
79Petechiae (HP:0000967)2.27115716
80Recurrent bronchitis (HP:0002837)2.26512328
81Granulocytopenia (HP:0001913)2.26039334
82Chronic diarrhea (HP:0002028)2.25202728
83Abnormality of the prostate (HP:0008775)2.24531378
84Abnormality of the pericardium (HP:0001697)2.22905383
85Osteolytic defects of the phalanges of the hand (HP:0009771)2.22463551
86Osteolytic defects of the hand bones (HP:0009699)2.22463551
87Abnormality of T cell physiology (HP:0011840)2.21902971
88Colitis (HP:0002583)2.21792012
89Anorexia (HP:0002039)2.21505896
90Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.21292379
91Arthralgia (HP:0002829)2.19158425
92IgG deficiency (HP:0004315)2.13533994
93Spontaneous hematomas (HP:0007420)2.13457203
94Abnormality of cells of the lymphoid lineage (HP:0012140)2.13251907
95Porencephaly (HP:0002132)2.13151826
96Disinhibition (HP:0000734)2.12034959
97Hypoproteinemia (HP:0003075)2.11640905
98Abnormality of proline metabolism (HP:0010907)2.09575222
99Hydroxyprolinuria (HP:0003080)2.09575222
100Skin ulcer (HP:0200042)2.07162513
101Neoplasm of the tracheobronchial system (HP:0100552)2.06956818
102Alveolar cell carcinoma (HP:0006519)2.04799489
103Lymphopenia (HP:0001888)2.03659161
104Inflammation of the large intestine (HP:0002037)2.01832022
105Increased IgE level (HP:0003212)1.99470481
106Sepsis (HP:0100806)1.98789124
107Glomerulopathy (HP:0100820)1.98112567
108Poor head control (HP:0002421)1.97388651
109Panhypogammaglobulinemia (HP:0003139)1.96246962
110Abnormality of the pleura (HP:0002103)1.96045829
111Thyroiditis (HP:0100646)1.95327232
112Acute hepatic failure (HP:0006554)1.94674503
1133-Methylglutaconic aciduria (HP:0003535)1.94423231
114Pulmonary fibrosis (HP:0002206)1.92547232
115Bone pain (HP:0002653)1.88808667
116Vertigo (HP:0002321)1.87895908
117Loss of speech (HP:0002371)1.86548358
118B lymphocytopenia (HP:0010976)1.85583298
119Hepatosplenomegaly (HP:0001433)1.85372468
120Gastrointestinal inflammation (HP:0004386)1.84467092
121Amaurosis fugax (HP:0100576)1.84315717
122Epistaxis (HP:0000421)1.83502801
123Hematochezia (HP:0002573)1.83420855
124Episodic fever (HP:0001954)1.82439317
125Amyotrophic lateral sclerosis (HP:0007354)1.81773087
126Albinism (HP:0001022)1.80229660
127Hypochromic anemia (HP:0001931)1.79536747
128Spondylolisthesis (HP:0003302)1.78877898
129Combined immunodeficiency (HP:0005387)1.78791556
130Stomach cancer (HP:0012126)1.75415531
131Recurrent sinusitis (HP:0011108)1.74578379
132Thrombophlebitis (HP:0004418)1.73698197
133Abnormality of the endocardium (HP:0004306)1.69726495
134Chronic sinusitis (HP:0011109)1.68240379
135IgM deficiency (HP:0002850)1.65754876
136Renal cortical cysts (HP:0000803)1.64585765

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.60536426
2TBK13.35102949
3IRAK43.25824112
4TXK3.20554174
5RIPK43.20250113
6IKBKB3.14586641
7PBK3.07350654
8JAK33.04250107
9IRAK32.96469065
10TYK22.88022463
11IKBKE2.86087408
12BLK2.85599457
13MAP3K132.60807721
14BMPR22.37950613
15MAP4K12.34921023
16JAK12.10731677
17CHUK2.09945883
18MAP4K21.90060518
19PIM21.86098919
20EPHA31.80633475
21MST41.80188955
22KIT1.68361632
23NEK91.64344973
24SYK1.49616585
25CAMKK21.42640338
26ZAP701.36986969
27CSK1.27460880
28TEC1.22168685
29EPHB11.20074826
30IRAK11.19104213
31PIM11.16839559
32ERN11.16359217
33BTK1.14701665
34HCK1.14588797
35RPS6KA41.13003074
36LCK1.11866779
37EIF2AK21.11419706
38INSRR1.09365064
39TRPM71.06643881
40LYN1.04144131
41STK41.01871982
42JAK21.01199275
43FGFR41.00858666
44CSF1R1.00576559
45FGFR31.00224175
46STK100.99477148
47MUSK0.98684614
48TAOK30.93712245
49ERBB30.92241378
50ABL20.89721891
51TRIM280.85322511
52NLK0.82716443
53NME20.81506226
54MARK30.78226443
55BMPR1B0.75187825
56MST1R0.74643529
57BMX0.72239952
58PRKCD0.71498671
59ITK0.71207204
60MATK0.69763040
61FRK0.69487858
62PAK30.68438545
63PRKCQ0.67531292
64SIK30.66346881
65PIK3CA0.65771501
66STK30.62351899
67TGFBR20.61518649
68NUAK10.60629076
69MOS0.60591979
70ABL10.60322444
71PTK2B0.59185988
72LRRK20.58317192
73SGK20.58201084
74FGR0.56094942
75FER0.56051519
76STK240.54340925
77YES10.51658465
78MAPKAPK20.50875231
79ARAF0.50678086
80IRAK20.50652386
81EIF2AK30.49069352
82TAOK20.48048895
83MAPK130.47087486
84EGFR0.46460062
85MAP2K30.46113715
86MAP3K50.45985862
87OXSR10.45326028
88EIF2AK10.44128590
89GRK70.43743270
90TAOK10.40366068
91GRK10.39864046
92MAPKAPK30.39578127
93GRK50.39331612
94KSR10.39287767
95ERBB40.36626941
96RPS6KA50.36244876
97MAP3K30.35251699
98GRK60.34600964
99MAP3K120.34432006
100PKN10.33814934
101WNK30.33548763
102IGF1R0.33348431
103BCR0.33336954
104PIK3CG0.33186425
105HIPK20.32558896
106TESK10.32361949
107MAP3K110.31488446
108MAP3K10.31011640
109AKT30.30979135
110TIE10.30203894
111SGK30.24909804
112CLK10.24308196
113RPS6KA60.24006767
114FLT30.22845219
115ACVR1B0.22658222
116PRKCE0.22376878
117FES0.21804655
118ADRBK20.20297514
119CDK60.16825400
120MAP3K100.16414329
121INSR0.16168138
122FYN0.15620912
123RAF10.15360461
124RPS6KA10.15118179
125MAP2K60.14683952
126MAPK30.11766899

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.85548160
2Allograft rejection_Homo sapiens_hsa053303.47288371
3Leishmaniasis_Homo sapiens_hsa051403.31732908
4NF-kappa B signaling pathway_Homo sapiens_hsa040643.12347257
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.86453567
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.78806613
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.69392223
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.66813911
9Type I diabetes mellitus_Homo sapiens_hsa049402.60073252
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.53362131
11Legionellosis_Homo sapiens_hsa051342.49867202
12Measles_Homo sapiens_hsa051622.34983082
13Rheumatoid arthritis_Homo sapiens_hsa053232.33172883
14Osteoclast differentiation_Homo sapiens_hsa043802.29129929
15Staphylococcus aureus infection_Homo sapiens_hsa051502.27029387
16* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.25918364
17TNF signaling pathway_Homo sapiens_hsa046682.19399246
18Malaria_Homo sapiens_hsa051442.17378160
19Pertussis_Homo sapiens_hsa051332.08976496
20Tuberculosis_Homo sapiens_hsa051522.04220708
21Autoimmune thyroid disease_Homo sapiens_hsa053202.03178744
22Asthma_Homo sapiens_hsa053102.01090500
23Influenza A_Homo sapiens_hsa051641.87350704
24African trypanosomiasis_Homo sapiens_hsa051431.77006231
25Primary immunodeficiency_Homo sapiens_hsa053401.76046339
26Herpes simplex infection_Homo sapiens_hsa051681.71893761
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.71222357
28Hematopoietic cell lineage_Homo sapiens_hsa046401.69040307
29Toxoplasmosis_Homo sapiens_hsa051451.62671336
30Salmonella infection_Homo sapiens_hsa051321.51045743
31B cell receptor signaling pathway_Homo sapiens_hsa046621.48449198
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.46174293
33Apoptosis_Homo sapiens_hsa042101.42921595
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42398905
35Chemokine signaling pathway_Homo sapiens_hsa040621.42147529
36Phagosome_Homo sapiens_hsa041451.40387464
37Antigen processing and presentation_Homo sapiens_hsa046121.37965129
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26170308
39Shigellosis_Homo sapiens_hsa051311.18792141
40Viral myocarditis_Homo sapiens_hsa054161.18230084
41Lysosome_Homo sapiens_hsa041421.16385218
42Hepatitis B_Homo sapiens_hsa051611.13386340
43T cell receptor signaling pathway_Homo sapiens_hsa046601.03170579
44Hepatitis C_Homo sapiens_hsa051601.00166087
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93463611
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90894034
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88600514
48Regulation of autophagy_Homo sapiens_hsa041400.86360845
49Amoebiasis_Homo sapiens_hsa051460.81133695
50Protein export_Homo sapiens_hsa030600.76765568
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75946100
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71352944
53Epstein-Barr virus infection_Homo sapiens_hsa051690.71002344
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.70064202
55Other glycan degradation_Homo sapiens_hsa005110.70028975
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68137892
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67974965
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61807811
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60312343
60Acute myeloid leukemia_Homo sapiens_hsa052210.60288284
61Prolactin signaling pathway_Homo sapiens_hsa049170.57852549
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.54772152
63Small cell lung cancer_Homo sapiens_hsa052220.54448910
64Pancreatic cancer_Homo sapiens_hsa052120.50594476
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.48629282
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47799924
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.46919130
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45926406
69Viral carcinogenesis_Homo sapiens_hsa052030.45079396
70Prion diseases_Homo sapiens_hsa050200.44896425
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44059661
72Platelet activation_Homo sapiens_hsa046110.43169757
73Basal transcription factors_Homo sapiens_hsa030220.43005302
74Chronic myeloid leukemia_Homo sapiens_hsa052200.42487359
75Proteasome_Homo sapiens_hsa030500.42268929
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42180883
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.40735364
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39525500
79Sulfur metabolism_Homo sapiens_hsa009200.39159373
80p53 signaling pathway_Homo sapiens_hsa041150.38532295
81Collecting duct acid secretion_Homo sapiens_hsa049660.34144807
82HTLV-I infection_Homo sapiens_hsa051660.32390300
83HIF-1 signaling pathway_Homo sapiens_hsa040660.24793156
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24360080
85Complement and coagulation cascades_Homo sapiens_hsa046100.24115631
86Circadian rhythm_Homo sapiens_hsa047100.24099538
87Peroxisome_Homo sapiens_hsa041460.22616107
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.21390087
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20402680
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20220554
91FoxO signaling pathway_Homo sapiens_hsa040680.19729768
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18265226
93MAPK signaling pathway_Homo sapiens_hsa040100.17126712
94Caffeine metabolism_Homo sapiens_hsa002320.16054623
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15227583
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14604623
97Ether lipid metabolism_Homo sapiens_hsa005650.14157363
98Type II diabetes mellitus_Homo sapiens_hsa049300.13639143
99Systemic lupus erythematosus_Homo sapiens_hsa053220.13581392
100Insulin resistance_Homo sapiens_hsa049310.13460053
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13222353
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.13063979
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12333878
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.12321662
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11626721
106PPAR signaling pathway_Homo sapiens_hsa033200.10396161
107Tryptophan metabolism_Homo sapiens_hsa003800.09507367
108Proteoglycans in cancer_Homo sapiens_hsa052050.09302968
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.09116144
110RNA degradation_Homo sapiens_hsa030180.09097074
111MicroRNAs in cancer_Homo sapiens_hsa052060.08153883
112Fatty acid biosynthesis_Homo sapiens_hsa000610.07193952
113Endocytosis_Homo sapiens_hsa041440.05446784
114Vibrio cholerae infection_Homo sapiens_hsa051100.05328813
115Sphingolipid metabolism_Homo sapiens_hsa006000.03740533
116Dorso-ventral axis formation_Homo sapiens_hsa043200.02724099
117Renin-angiotensin system_Homo sapiens_hsa046140.01628763
118Mineral absorption_Homo sapiens_hsa049780.01093470

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