TANC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.60490798
2hemidesmosome assembly (GO:0031581)4.94268783
3paraxial mesoderm development (GO:0048339)3.88345085
4bundle of His cell to Purkinje myocyte communication (GO:0086069)3.79462012
5axon extension involved in axon guidance (GO:0048846)3.75124077
6neuron projection extension involved in neuron projection guidance (GO:1902284)3.75124077
7plasma membrane repair (GO:0001778)3.73480851
8glomerular basement membrane development (GO:0032836)3.68358229
9vascular endothelial growth factor signaling pathway (GO:0038084)3.67576452
10glomerular visceral epithelial cell development (GO:0072015)3.66531304
11cell-substrate junction assembly (GO:0007044)3.46727160
12gap junction assembly (GO:0016264)3.42228003
13epithelial cell-cell adhesion (GO:0090136)3.25549933
14cytoskeletal anchoring at plasma membrane (GO:0007016)3.25404335
15hippo signaling (GO:0035329)3.20716550
16glomerular epithelial cell development (GO:0072310)3.12902119
17retina vasculature morphogenesis in camera-type eye (GO:0061299)3.12030008
18branching involved in salivary gland morphogenesis (GO:0060445)3.11247794
19regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.07416485
20endothelial cell morphogenesis (GO:0001886)3.07007248
21lymphangiogenesis (GO:0001946)3.05572904
22renal filtration (GO:0097205)3.01934874
23planar cell polarity pathway involved in neural tube closure (GO:0090179)3.01536906
24regulation of water loss via skin (GO:0033561)3.01117586
25establishment of skin barrier (GO:0061436)2.98924029
26adherens junction assembly (GO:0034333)2.97096958
27regulation of axon extension involved in axon guidance (GO:0048841)2.94357313
28regulation of transforming growth factor beta2 production (GO:0032909)2.93058195
29polarized epithelial cell differentiation (GO:0030859)2.92762733
30cell migration involved in heart development (GO:0060973)2.92515411
31regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.92080328
32regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.89806783
33mesenchymal-epithelial cell signaling (GO:0060638)2.83349602
34bone trabecula formation (GO:0060346)2.81706455
35regulation of hippo signaling (GO:0035330)2.80905794
36cell migration involved in sprouting angiogenesis (GO:0002042)2.80096584
37cell-substrate adherens junction assembly (GO:0007045)2.79589666
38focal adhesion assembly (GO:0048041)2.79589666
39endocardial cushion development (GO:0003197)2.79374497
40glomerular filtration (GO:0003094)2.77215294
41negative regulation of axon extension involved in axon guidance (GO:0048843)2.74136487
42chondrocyte proliferation (GO:0035988)2.73259660
43keratinocyte differentiation (GO:0030216)2.71316736
44protein localization to endosome (GO:0036010)2.71314415
45cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.70162686
46regulation of tight junction assembly (GO:2000810)2.68551276
47basement membrane organization (GO:0071711)2.66194173
48coronary vasculature morphogenesis (GO:0060977)2.65649504
49protein heterotrimerization (GO:0070208)2.65454435
50endothelial cell chemotaxis (GO:0035767)2.63760981
51negative regulation of keratinocyte proliferation (GO:0010839)2.61176188
52collagen fibril organization (GO:0030199)2.61069126
53lateral sprouting from an epithelium (GO:0060601)2.60987868
54regulation of cell fate specification (GO:0042659)2.60902732
55regulation of axon guidance (GO:1902667)2.60661315
56semaphorin-plexin signaling pathway (GO:0071526)2.60184208
57regulation of cardioblast differentiation (GO:0051890)2.58709852
58endothelium development (GO:0003158)2.58552135
59negative regulation of chondrocyte differentiation (GO:0032331)2.58527413
60smooth muscle tissue development (GO:0048745)2.57592802
61negative regulation of fatty acid transport (GO:2000192)2.56292209
62outflow tract septum morphogenesis (GO:0003148)2.55453617
63establishment of apical/basal cell polarity (GO:0035089)2.55380690
64fibroblast migration (GO:0010761)2.55063172
65atrioventricular valve morphogenesis (GO:0003181)2.53506436
66negative regulation of cell fate specification (GO:0009996)2.52817531
67skin morphogenesis (GO:0043589)2.52622071
68dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.52419283
69adherens junction organization (GO:0034332)2.51416525
70lung-associated mesenchyme development (GO:0060484)2.51098921
71vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.49442814
72wound healing, spreading of epidermal cells (GO:0035313)2.49248978
73regulation of glomerular filtration (GO:0003093)2.48872466
74endodermal cell differentiation (GO:0035987)2.46878248
75embryonic camera-type eye development (GO:0031076)2.46172511
76chemical homeostasis within a tissue (GO:0048875)2.46155008
77heart valve morphogenesis (GO:0003179)2.45985167
78ephrin receptor signaling pathway (GO:0048013)2.44457366
79lymph vessel development (GO:0001945)2.43799390
80non-canonical Wnt signaling pathway (GO:0035567)2.43642834
81keratinocyte proliferation (GO:0043616)2.42979430
82insulin-like growth factor receptor signaling pathway (GO:0048009)2.42448524
83branching involved in prostate gland morphogenesis (GO:0060442)2.42422106
84somatic stem cell division (GO:0048103)2.41440225
85artery development (GO:0060840)2.41289526
86ectoderm development (GO:0007398)2.40879001
87chondrocyte development (GO:0002063)2.40775985
88positive regulation of osteoblast proliferation (GO:0033690)2.39407911
89cardiac myofibril assembly (GO:0055003)2.39352533
90negative regulation of protein localization to cell surface (GO:2000009)2.39340240
91establishment of nucleus localization (GO:0040023)2.39301241
92regulation of endothelial cell chemotaxis (GO:2001026)2.38780532
93morphogenesis of an epithelial sheet (GO:0002011)2.38651632
94mesodermal cell differentiation (GO:0048333)2.38034410
95Golgi transport vesicle coating (GO:0048200)2.37779521
96COPI coating of Golgi vesicle (GO:0048205)2.37779521
97cell adhesion mediated by integrin (GO:0033627)2.36806402
98Notch signaling involved in heart development (GO:0061314)2.36422325
99cell communication by electrical coupling (GO:0010644)2.36097073
100anterior/posterior axis specification, embryo (GO:0008595)2.35224470
101regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.34686438
102mesenchyme morphogenesis (GO:0072132)2.34079016
103collecting duct development (GO:0072044)2.33927083
104cell surface receptor signaling pathway involved in heart development (GO:0061311)2.33900147
105metanephric mesenchyme development (GO:0072075)2.33121517
106positive regulation of epithelial to mesenchymal transition (GO:0010718)2.32631368
107endocardial cushion morphogenesis (GO:0003203)2.32409102
108notochord development (GO:0030903)2.32225446
109Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.30511835
110multicellular organismal water homeostasis (GO:0050891)2.30117661
111cardiac septum morphogenesis (GO:0060411)2.29221735
112positive regulation of catenin import into nucleus (GO:0035413)2.28395836
113positive regulation of p38MAPK cascade (GO:1900745)2.28354578
114cell-cell junction assembly (GO:0007043)2.27972834
115cardiac cell development (GO:0055006)2.27432425
116regulation of chondrocyte differentiation (GO:0032330)2.27169647
117negative regulation of catenin import into nucleus (GO:0035414)2.26974878
118cell communication involved in cardiac conduction (GO:0086065)2.26587917
119regulation of establishment of planar polarity (GO:0090175)2.26459807
120negative regulation of axon guidance (GO:1902668)2.25737367
121regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.24522297
122regulation of integrin-mediated signaling pathway (GO:2001044)2.24328507
123apical protein localization (GO:0045176)2.23884646
124positive regulation of mesenchymal cell proliferation (GO:0002053)2.22958757
125outer ear morphogenesis (GO:0042473)2.22116176
126extracellular matrix assembly (GO:0085029)2.21750094
127blood vessel endothelial cell migration (GO:0043534)2.21697032
128heart morphogenesis (GO:0003007)2.21653702
129regulation of catenin import into nucleus (GO:0035412)2.21267724
130embryonic foregut morphogenesis (GO:0048617)2.21261620
131kidney mesenchyme development (GO:0072074)2.21170754
132sequestering of extracellular ligand from receptor (GO:0035581)2.21166015
133substrate adhesion-dependent cell spreading (GO:0034446)2.20977488
134regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.20604705
135sarcomere organization (GO:0045214)2.19973840
136myelination in peripheral nervous system (GO:0022011)2.19918936
137establishment of tissue polarity (GO:0007164)2.19911785
138establishment of planar polarity (GO:0001736)2.19911785
139cell junction assembly (GO:0034329)2.19218826
140surfactant homeostasis (GO:0043129)2.18676090
141cellular response to vitamin D (GO:0071305)2.18460090

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.98958475
2TRIM28_21343339_ChIP-Seq_HEK293_Human2.65691452
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.55396610
4CLOCK_20551151_ChIP-Seq_293T_Human2.21194207
5* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.19812384
6AR_21909140_ChIP-Seq_LNCAP_Human2.14410042
7* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.03653509
8EZH2_22144423_ChIP-Seq_EOC_Human2.02185491
9ESR1_21235772_ChIP-Seq_MCF-7_Human1.98168911
10* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.96276618
11ESR2_21235772_ChIP-Seq_MCF-7_Human1.85065414
12ZNF263_19887448_ChIP-Seq_K562_Human1.82708850
13EP300_21415370_ChIP-Seq_HL-1_Mouse1.79191054
14RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76357588
15EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76357588
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.75775864
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.75775864
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.75775864
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.74231405
20AHR_22903824_ChIP-Seq_MCF-7_Human1.73822533
21TP53_16413492_ChIP-PET_HCT116_Human1.73608029
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.69954806
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.66887763
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.65558453
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62279647
26* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.61120222
27* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.58457180
28* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.58457180
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.57150819
30* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51000692
31CJUN_26792858_Chip-Seq_BT549_Human1.50549549
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49548760
33ARNT_22903824_ChIP-Seq_MCF-7_Human1.49259890
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48956041
35* TCF4_18268006_ChIP-ChIP_LS174T_Human1.48706648
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47771675
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46672852
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46153935
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46134680
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46018631
41CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.45785352
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45325514
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44918992
44TP53_18474530_ChIP-ChIP_U2OS_Human1.44883176
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44035610
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.43834100
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43549744
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.43051535
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.41371351
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41066865
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.40275180
52SALL4_18804426_ChIP-ChIP_XEN_Mouse1.39940850
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39835748
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35693453
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35693453
56TP53_20018659_ChIP-ChIP_R1E_Mouse1.34866307
57GBX2_23144817_ChIP-Seq_PC3_Human1.34346244
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34287961
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.33821841
60ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.33229446
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32330608
62DROSHA_22980978_ChIP-Seq_HELA_Human1.31235571
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30347851
64NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30012738
65FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29627234
66* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29160195
67PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.28320175
68* SMAD3_21741376_ChIP-Seq_HESCs_Human1.27053163
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26422448
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26182710
71* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24718100
72P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24710497
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23158449
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.22775453
75* ISL1_27105846_Chip-Seq_CPCs_Mouse1.22479640
76* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22078722
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21745622
78UBF1/2_26484160_Chip-Seq_HMECs_Human1.20750434
79SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20340544
80* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19621869
81RXR_22108803_ChIP-Seq_LS180_Human1.18749284
82MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18546123
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18371505
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17708156
85KDM2B_26808549_Chip-Seq_K562_Human1.16012773
86* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15796519
87WT1_19549856_ChIP-ChIP_CCG9911_Human1.15479012
88* GATA2_21666600_ChIP-Seq_HMVEC_Human1.14674533
89SOX2_20726797_ChIP-Seq_SW620_Human1.14262712
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13858584
91* RING1B_27294783_Chip-Seq_NPCs_Mouse1.13810315
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13005958
93* PIAS1_25552417_ChIP-Seq_VCAP_Human1.12378787
94NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11340793
95* FOXA2_19822575_ChIP-Seq_HepG2_Human1.10264806
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09829520
97FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.08735616
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08627307
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06739095
100BRD4_25478319_ChIP-Seq_HGPS_Human1.06649374
101CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06240396
102* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06107988
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05406447
104* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04872271
105KLF5_25053715_ChIP-Seq_YYC3_Human1.04760038
106* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04311389
107BCAT_22108803_ChIP-Seq_LS180_Human1.04110004
108TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04008839
109EZH2_27294783_Chip-Seq_ESCs_Mouse1.03904221
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03577578
111ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03356453
112* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03249502
113CDX2_20551321_ChIP-Seq_CACO-2_Human1.03204165
114TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02719121
115* TP63_23658742_ChIP-Seq_EP156T_Human1.02182398
116RACK7_27058665_Chip-Seq_MCF-7_Human1.02180020
117* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01483946
118TBX20_22328084_ChIP-Seq_HEART_Mouse1.01413926
119TBX20_22080862_ChIP-Seq_HEART_Mouse1.01413926
120MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01264198
121FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01139149
122AR_21572438_ChIP-Seq_LNCaP_Human1.00618521
123RUNX1_27514584_Chip-Seq_MCF-7_Human1.00316288
124HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97418670
125SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97416131
126YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96257764
127* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96179902
128* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96140168
129TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95252494
130* SMAD4_21799915_ChIP-Seq_A2780_Human0.94486170
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93912732
132NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93884335
133LXR_22158963_ChIP-Seq_LIVER_Mouse0.92442317
134GATA1_22025678_ChIP-Seq_K562_Human0.91548490
135GATA3_24758297_ChIP-Seq_MCF-7_Human0.91368304

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile3.93637479
2MP0003941_abnormal_skin_development3.87375573
3MP0004272_abnormal_basement_membrane3.11995004
4MP0002796_impaired_skin_barrier3.04975185
5MP0008438_abnormal_cutaneous_collagen2.92882612
6MP0010234_abnormal_vibrissa_follicle2.89945948
7MP0005623_abnormal_meninges_morphology2.82545846
8MP0003705_abnormal_hypodermis_morpholog2.59405366
9MP0003566_abnormal_cell_adhesion2.48250443
10MP0000383_abnormal_hair_follicle2.25742005
11MP0010678_abnormal_skin_adnexa2.19031186
12MP0005171_absent_coat_pigmentation2.18201880
13MP0002060_abnormal_skin_morphology2.11921652
14MP0005409_darkened_coat_color2.07132907
15MP0005501_abnormal_skin_physiology1.93307384
16MP0010030_abnormal_orbit_morphology1.88847545
17MP0000566_synostosis1.81190724
18MP0010368_abnormal_lymphatic_system1.77861104
19MP0000762_abnormal_tongue_morphology1.76795709
20MP0002254_reproductive_system_inflammat1.75547086
21MP0003385_abnormal_body_wall1.68548980
22MP0002877_abnormal_melanocyte_morpholog1.61239501
23MP0005503_abnormal_tendon_morphology1.59515602
24MP0000579_abnormal_nail_morphology1.58740594
25MP0000467_abnormal_esophagus_morphology1.56126057
26MP0001346_abnormal_lacrimal_gland1.51599175
27MP0003091_abnormal_cell_migration1.50937669
28MP0001958_emphysema1.48870996
29MP0003453_abnormal_keratinocyte_physiol1.48666847
30MP0009780_abnormal_chondrocyte_physiolo1.48447674
31MP0004036_abnormal_muscle_relaxation1.46346517
32MP0000751_myopathy1.45618486
33MP0010771_integument_phenotype1.45064040
34MP0004084_abnormal_cardiac_muscle1.44759385
35MP0004185_abnormal_adipocyte_glucose1.44727307
36MP0002009_preneoplasia1.44301661
37MP0010352_gastrointestinal_tract_polyps1.42215981
38MP0003045_fibrosis1.41028737
39MP0000733_abnormal_muscle_development1.35010687
40MP0003279_aneurysm1.33579848
41MP0004381_abnormal_hair_follicle1.28629096
42MP0002098_abnormal_vibrissa_morphology1.28498598
43MP0003136_yellow_coat_color1.27260950
44MP0005508_abnormal_skeleton_morphology1.26958847
45MP0000537_abnormal_urethra_morphology1.26669261
46MP0003755_abnormal_palate_morphology1.24634194
47MP0003828_pulmonary_edema1.23445865
48MP0001216_abnormal_epidermal_layer1.23347596
49MP0005330_cardiomyopathy1.23032825
50MP0002249_abnormal_larynx_morphology1.22772458
51MP0000647_abnormal_sebaceous_gland1.21915630
52MP0009250_abnormal_appendicular_skeleto1.20597338
53MP0001849_ear_inflammation1.20348434
54MP0000462_abnormal_digestive_system1.18060377
55MP0006138_congestive_heart_failure1.15177990
56MP0001299_abnormal_eye_distance/1.13930654
57MP0004782_abnormal_surfactant_physiolog1.13444134
58MP0002233_abnormal_nose_morphology1.12988167
59MP0001879_abnormal_lymphatic_vessel1.12169880
60MP0002108_abnormal_muscle_morphology1.11163767
61MP0003935_abnormal_craniofacial_develop1.09767611
62MP0001661_extended_life_span1.08975010
63MP0000428_abnormal_craniofacial_morphol1.08859853
64MP0004858_abnormal_nervous_system1.08171185
65MP0005023_abnormal_wound_healing1.08102362
66MP0000432_abnormal_head_morphology1.07255819
67MP0004484_altered_response_of1.05870058
68MP0000534_abnormal_ureter_morphology1.05679231
69MP0003937_abnormal_limbs/digits/tail_de1.05027616
70MP0008775_abnormal_heart_ventricle1.02971249
71MP0003942_abnormal_urinary_system1.02898768
72MP0004215_abnormal_myocardial_fiber1.01575230
73MP0005595_abnormal_vascular_smooth1.00513988
74MP0000377_abnormal_hair_follicle1.00311686
75MP0002896_abnormal_bone_mineralization0.99024257
76MP0002697_abnormal_eye_size0.98470391
77MP0002295_abnormal_pulmonary_circulatio0.97878218
78MP0002925_abnormal_cardiovascular_devel0.97544733
79MP0003950_abnormal_plasma_membrane0.97414077
80MP0005076_abnormal_cell_differentiation0.97055041
81MP0005197_abnormal_uvea_morphology0.96888142
82MP0000750_abnormal_muscle_regeneration0.95577604
83MP0002234_abnormal_pharynx_morphology0.95184710
84MP0005377_hearing/vestibular/ear_phenot0.95157514
85MP0003878_abnormal_ear_physiology0.95157514
86MP0005666_abnormal_adipose_tissue0.94436688
87MP0010630_abnormal_cardiac_muscle0.94308580
88MP0000003_abnormal_adipose_tissue0.93815758
89MP0000013_abnormal_adipose_tissue0.93601954
90MP0002972_abnormal_cardiac_muscle0.92679473
91MP0000767_abnormal_smooth_muscle0.92385849
92MP0000427_abnormal_hair_cycle0.88806802
93MP0004087_abnormal_muscle_fiber0.88125868
94MP0005187_abnormal_penis_morphology0.86892949
95MP0005248_abnormal_Harderian_gland0.86826401
96MP0002177_abnormal_outer_ear0.85839239
97MP0002282_abnormal_trachea_morphology0.85780657
98MP0001784_abnormal_fluid_regulation0.85388587
99MP0006054_spinal_hemorrhage0.84735281
100MP0005367_renal/urinary_system_phenotyp0.84439229
101MP0000516_abnormal_urinary_system0.84439229
102MP0005620_abnormal_muscle_contractility0.83532503
103MP0009384_cardiac_valve_regurgitation0.83221646
104MP0002128_abnormal_blood_circulation0.83123657
105MP0001614_abnormal_blood_vessel0.82348719
106MP0005375_adipose_tissue_phenotype0.81908317
107MP0000749_muscle_degeneration0.81864910
108MP0001915_intracranial_hemorrhage0.81638748
109MP0005670_abnormal_white_adipose0.81468185
110MP0004859_abnormal_synaptic_plasticity0.80864069
111MP0002116_abnormal_craniofacial_bone0.80651955
112MP0003283_abnormal_digestive_organ0.80473710
113MP0009053_abnormal_anal_canal0.79276162
114MP0001340_abnormal_eyelid_morphology0.77887304
115MP0005257_abnormal_intraocular_pressure0.77526863
116MP0003115_abnormal_respiratory_system0.76891860
117MP0002269_muscular_atrophy0.75410042
118MP0000163_abnormal_cartilage_morphology0.73966225
119MP0002092_abnormal_eye_morphology0.73497463
120MP0001191_abnormal_skin_condition0.73199223
121MP0004233_abnormal_muscle_weight0.73067471
122MP0000627_abnormal_mammary_gland0.72995200
123MP0002111_abnormal_tail_morphology0.72293230
124MP0004085_abnormal_heartbeat0.71679601
125MP0000747_muscle_weakness0.71219140
126MP0002109_abnormal_limb_morphology0.70789867
127MP0000266_abnormal_heart_morphology0.70248599
128MP0001177_atelectasis0.70050243
129MP0003984_embryonic_growth_retardation0.69624811

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)4.17873742
2Atrophic scars (HP:0001075)3.74555160
3Premature rupture of membranes (HP:0001788)3.72045761
4Shallow orbits (HP:0000586)3.68359151
5Broad metatarsal (HP:0001783)3.60521276
6Arterial tortuosity (HP:0005116)3.43113094
7Vascular tortuosity (HP:0004948)3.32217308
8Protrusio acetabuli (HP:0003179)3.21927819
9Increased connective tissue (HP:0009025)3.12291867
10Milia (HP:0001056)2.94168217
11Ankle contracture (HP:0006466)2.89071217
12Hyporeflexia of lower limbs (HP:0002600)2.77743333
13Osteolytic defects of the phalanges of the hand (HP:0009771)2.72084426
14Osteolytic defects of the hand bones (HP:0009699)2.72084426
15Short nail (HP:0001799)2.60553481
16Fragile skin (HP:0001030)2.60078730
17Lip pit (HP:0100267)2.55372488
18Overgrowth (HP:0001548)2.54239041
19Distal lower limb muscle weakness (HP:0009053)2.53101090
20Ventricular tachycardia (HP:0004756)2.48162688
21Hypotrichosis (HP:0001006)2.45578080
22Onycholysis (HP:0001806)2.40534853
23Cerebral aneurysm (HP:0004944)2.37549816
24Hypoplasia of the iris (HP:0007676)2.37324251
25Vertebral arch anomaly (HP:0008438)2.36310852
26Aplasia cutis congenita (HP:0001057)2.32510965
27Hip contracture (HP:0003273)2.25973786
28Coronal craniosynostosis (HP:0004440)2.23705493
29Broad face (HP:0000283)2.21907342
30Abnormality of the nasal septum (HP:0000419)2.21191735
31Distal lower limb amyotrophy (HP:0008944)2.19800176
32Bronchomalacia (HP:0002780)2.13463668
33Dysmetric saccades (HP:0000641)2.12970904
34Difficulty climbing stairs (HP:0003551)2.12340022
35Neonatal short-limb short stature (HP:0008921)2.11680251
36Difficulty running (HP:0009046)2.11487654
37Aortic dissection (HP:0002647)2.09882784
38Mildly elevated creatine phosphokinase (HP:0008180)2.09475669
39Hypoplastic ischia (HP:0003175)2.08706496
40Hyperacusis (HP:0010780)2.08606457
41Limited hip movement (HP:0008800)2.05939323
42Short hallux (HP:0010109)2.05818620
43Advanced eruption of teeth (HP:0006288)2.03540171
44Knee flexion contracture (HP:0006380)2.02587293
45Sudden death (HP:0001699)2.02316282
46Spinal rigidity (HP:0003306)2.00481384
47Plantar hyperkeratosis (HP:0007556)1.99824838
48Hypoplastic labia majora (HP:0000059)1.99639108
49Abnormality of the ischium (HP:0003174)1.99460792
50Esophageal atresia (HP:0002032)1.98898679
51Turricephaly (HP:0000262)1.98530344
52Aplasia involving bones of the upper limbs (HP:0009823)1.98084962
53Aplasia of the phalanges of the hand (HP:0009802)1.98084962
54Aplasia involving bones of the extremities (HP:0009825)1.98084962
55Bundle branch block (HP:0011710)1.97798139
56Scapular winging (HP:0003691)1.97492073
57Wide anterior fontanel (HP:0000260)1.93014391
58Muscle fiber splitting (HP:0003555)1.91777625
59Natal tooth (HP:0000695)1.91713914
60Hyperactive renin-angiotensin system (HP:0000841)1.91213909
61Abnormality of dentin (HP:0010299)1.89790704
62Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.89696928
63Short 4th metacarpal (HP:0010044)1.89696928
64Laryngomalacia (HP:0001601)1.88857665
65Mesomelia (HP:0003027)1.88787254
66Woolly hair (HP:0002224)1.86715406
67Abnormality of the labia majora (HP:0012881)1.86458523
68Aplasia/Hypoplasia of the hallux (HP:0008362)1.86306908
69Down-sloping shoulders (HP:0200021)1.84417884
70Follicular hyperkeratosis (HP:0007502)1.83765059
71Short clavicles (HP:0000894)1.82175685
72Selective tooth agenesis (HP:0001592)1.81811102
73Soft skin (HP:0000977)1.81780941
74Cutaneous finger syndactyly (HP:0010554)1.80564090
75Pulmonary artery stenosis (HP:0004415)1.79575733
76Increased variability in muscle fiber diameter (HP:0003557)1.78788786
77Bladder diverticulum (HP:0000015)1.78073174
78Type 1 muscle fiber predominance (HP:0003803)1.77873068
79Buphthalmos (HP:0000557)1.76228228
80Ulnar bowing (HP:0003031)1.75798391
81Blue sclerae (HP:0000592)1.75541471
82Pterygium (HP:0001059)1.75160906
83Ankyloglossia (HP:0010296)1.75037428
84Joint laxity (HP:0001388)1.74791351
85Mitral valve prolapse (HP:0001634)1.72568879
86Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.71115472
87Lower limb amyotrophy (HP:0007210)1.70472619
88Abnormality of the distal phalanges of the toes (HP:0010182)1.69513642
89Fragile nails (HP:0001808)1.68122282
90Alopecia of scalp (HP:0002293)1.67355374
91Atrial fibrillation (HP:0005110)1.67166406
92Aplasia/Hypoplasia of the clavicles (HP:0006710)1.66841596
93Hypopigmentation of the fundus (HP:0007894)1.66776023
94Curly hair (HP:0002212)1.65806713
95Cervical subluxation (HP:0003308)1.65610404
96Abnormality of the salivary glands (HP:0010286)1.64919621
97Flat acetabular roof (HP:0003180)1.64696903
98Abnormality of the parietal bone (HP:0002696)1.64574159
99Genu recurvatum (HP:0002816)1.64334270
100Neonatal death (HP:0003811)1.64085920
101Enlarged penis (HP:0000040)1.63855519
102Abnormality of molar morphology (HP:0011070)1.62009965
103Abnormality of molar (HP:0011077)1.62009965
104Protruding ear (HP:0000411)1.61679818
105Abnormal atrioventricular conduction (HP:0005150)1.61237756
106Bradycardia (HP:0001662)1.60249293
107Spinal cord lesions (HP:0100561)1.60248568
108Syringomyelia (HP:0003396)1.60248568
109Wormian bones (HP:0002645)1.59939326
110Absent toe (HP:0010760)1.59719075
111Atrioventricular block (HP:0001678)1.59526028
112Cutaneous syndactyly (HP:0012725)1.59202291
113Abnormality of the distal phalanx of the thumb (HP:0009617)1.58570940
114Hypoplasia of dental enamel (HP:0006297)1.58401648
115Bowel diverticulosis (HP:0005222)1.58369224
116Abnormality of the phalanges of the hallux (HP:0010057)1.57614321
117Abnormality of the dental root (HP:0006486)1.57034914
118Taurodontia (HP:0000679)1.57034914
119Abnormality of permanent molar morphology (HP:0011071)1.57034914
120Wrist flexion contracture (HP:0001239)1.56919522
121Aneurysm (HP:0002617)1.56673203
122Increased circulating renin level (HP:0000848)1.56643721
123Hyperextensible skin (HP:0000974)1.56485407
124Elbow flexion contracture (HP:0002987)1.55736289
125Oligodontia (HP:0000677)1.55711440
126Dilatation of the ascending aorta (HP:0005111)1.55689107
127Skin pits (HP:0100276)1.55561954
128Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.54566756
129Mitral stenosis (HP:0001718)1.54071308
130Absent frontal sinuses (HP:0002688)1.54017218
131Urethral obstruction (HP:0000796)1.53256232
132Aortic aneurysm (HP:0004942)1.52868601
133Primary atrial arrhythmia (HP:0001692)1.52794154
134Abnormality of the 2nd finger (HP:0004100)1.52747575
135Mitral regurgitation (HP:0001653)1.52747183
136Abnormality of the calf musculature (HP:0001430)1.52650876
137Lipoatrophy (HP:0100578)1.52521981
138Abnormality of carpal bone ossification (HP:0006257)1.52510465
139Vertebral compression fractures (HP:0002953)1.52461354
140Bell-shaped thorax (HP:0001591)1.51406825
141Pili torti (HP:0003777)1.50863851
142Abnormality of the right ventricle (HP:0001707)1.50855252
143Premature skin wrinkling (HP:0100678)1.50724614
144Popliteal pterygium (HP:0009756)1.50714852
145Acanthosis nigricans (HP:0000956)1.50250427
146Germ cell neoplasia (HP:0100728)1.50189875
147Abnormal ossification of hand bones (HP:0005921)1.50115860
148Insomnia (HP:0100785)1.49358285
149Focal segmental glomerulosclerosis (HP:0000097)1.49288214
150Cubitus valgus (HP:0002967)1.49258443

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.81970077
2FER2.99869483
3DDR22.90881853
4AKT32.90626797
5TTN2.80263501
6CDK122.77890850
7PDGFRA2.73385189
8RIPK12.63193232
9EPHA22.55108079
10TIE12.53307374
11MYLK2.41474640
12MST1R2.19905714
13MET2.16942490
14NTRK31.99280714
15DMPK1.99171327
16BMX1.87037945
17NEK91.80239643
18LATS21.77091837
19TRPM71.74783551
20STK38L1.74219891
21FGFR21.74185149
22EPHB21.62924285
23SIK11.50407643
24PTK21.48731220
25CAMK1D1.42567602
26MAPKAPK31.42510080
27TGFBR21.40878802
28STK381.37811424
29PDGFRB1.33360215
30BRD41.32218348
31MAP3K21.26332433
32PTK61.23118080
33MAP3K71.22084898
34LMTK21.21000305
35STK241.19700267
36CAMK1G1.19429549
37ERBB41.18585534
38ZAK1.17563245
39RPS6KB21.12782670
40WNK11.11348574
41FGFR11.10630479
42PTK2B1.10119985
43STK31.08065883
44MARK21.04382270
45EEF2K1.03271075
46SMG11.03178967
47MTOR1.00718398
48SCYL20.99606286
49PRKD20.98922617
50EPHA30.98722740
51MAP3K30.93945143
52WNK40.92623433
53PAK30.92251500
54PBK0.89019438
55MELK0.87804010
56TYRO30.81625465
57CDC42BPA0.80176942
58PRKD30.79456695
59PNCK0.78952132
60BRSK20.77615136
61PKN20.75869193
62KDR0.75662333
63FGFR30.74869355
64TTK0.73848809
65PRKD10.73524066
66STK390.73481512
67PDK20.73014400
68PAK20.71373171
69CDK60.70159951
70FGFR40.69528741
71EPHA40.68465616
72EPHB10.68042618
73ROCK10.67172443
74CAMK40.66298016
75TRIB30.64915689
76RPS6KA20.63301288
77PRKAA20.63019029
78ILK0.60695090
79ROCK20.60477934
80MAPK70.59880513
81PRKCE0.58347819
82PAK40.56867736
83MAP3K60.56465733
84ERBB30.54663331
85RET0.54351386
86INSR0.54189622
87NTRK10.53796883
88NEK60.53653266
89FRK0.51584945
90CAMK10.51435716
91SGK10.48271172
92MOS0.48241729
93PRKG20.48229203
94OXSR10.46104868
95PIK3CA0.45331461
96NUAK10.43431007
97SRC0.42576107
98PLK20.42175979
99PRKAA10.41493885
100IGF1R0.41290819
101SGK20.41134686
102BCR0.39659537
103ERBB20.39537893
104CSNK1A1L0.38348962
105STK100.37361971
106TGFBR10.36505846
107OBSCN0.36075177
108CAMK2D0.34534988
109LRRK20.34462370
110CAMK2B0.33745490
111ICK0.33314449
112CAMK2A0.32712689
113CSNK1E0.32308820
114WEE10.32277198
115MAPKAPK50.31487338
116MUSK0.31212655
117* MAPK10.31029102
118MAP2K10.30776161
119PRKCH0.30429049
120SGK30.30283899
121MAPK100.29994013
122AKT20.29911689
123RPS6KB10.29806929
124CDK70.29154458
125CDK90.28657415
126AKT10.28486701
127PRKACB0.27767228
128GSK3A0.27392927
129CSNK1D0.26223907
130FGR0.26174422
131FLT30.25336578
132PIM20.22344781
133CAMK2G0.21821522

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.77081583
2Adherens junction_Homo sapiens_hsa045202.49051542
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.38287575
4Basal cell carcinoma_Homo sapiens_hsa052172.04683571
5Focal adhesion_Homo sapiens_hsa045102.04572980
6Dilated cardiomyopathy_Homo sapiens_hsa054141.95804006
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.85774289
8Hippo signaling pathway_Homo sapiens_hsa043901.85764072
9Proteoglycans in cancer_Homo sapiens_hsa052051.74186791
10Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.65873900
11Axon guidance_Homo sapiens_hsa043601.58662271
12Protein digestion and absorption_Homo sapiens_hsa049741.58579009
13Tight junction_Homo sapiens_hsa045301.58436535
14MicroRNAs in cancer_Homo sapiens_hsa052061.57614099
15Hedgehog signaling pathway_Homo sapiens_hsa043401.54827941
16Melanogenesis_Homo sapiens_hsa049161.51399275
17Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.50795747
18Amoebiasis_Homo sapiens_hsa051461.42809986
19Small cell lung cancer_Homo sapiens_hsa052221.42028856
20Dorso-ventral axis formation_Homo sapiens_hsa043201.37829084
21TGF-beta signaling pathway_Homo sapiens_hsa043501.34555801
22Salivary secretion_Homo sapiens_hsa049701.32791686
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.31605990
24Rap1 signaling pathway_Homo sapiens_hsa040151.30077290
25Wnt signaling pathway_Homo sapiens_hsa043101.29714942
26Regulation of actin cytoskeleton_Homo sapiens_hsa048101.29411184
27Gastric acid secretion_Homo sapiens_hsa049711.25978387
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22408373
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22071015
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21275420
31Long-term potentiation_Homo sapiens_hsa047201.21084085
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20674922
33Circadian entrainment_Homo sapiens_hsa047131.18312095
34Notch signaling pathway_Homo sapiens_hsa043301.18298425
35GnRH signaling pathway_Homo sapiens_hsa049121.16842737
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16707634
37Histidine metabolism_Homo sapiens_hsa003401.14144776
38Melanoma_Homo sapiens_hsa052181.14128851
39Bladder cancer_Homo sapiens_hsa052191.13102369
40Glutamatergic synapse_Homo sapiens_hsa047241.11942273
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09752743
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08340078
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.06612290
44Calcium signaling pathway_Homo sapiens_hsa040201.06094797
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.04681893
46Pathways in cancer_Homo sapiens_hsa052001.04135454
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.03239429
48Oxytocin signaling pathway_Homo sapiens_hsa049211.03017048
49Ovarian steroidogenesis_Homo sapiens_hsa049131.02973091
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02631779
51Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01379867
52Glioma_Homo sapiens_hsa052141.01140523
53Long-term depression_Homo sapiens_hsa047301.00774216
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00443646
55cAMP signaling pathway_Homo sapiens_hsa040241.00371145
56PI3K-Akt signaling pathway_Homo sapiens_hsa041510.99319010
57Renin secretion_Homo sapiens_hsa049240.98417187
58Prion diseases_Homo sapiens_hsa050200.96754878
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.96020481
60Nicotine addiction_Homo sapiens_hsa050330.96016102
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.94423585
62Ras signaling pathway_Homo sapiens_hsa040140.93824811
63Fatty acid biosynthesis_Homo sapiens_hsa000610.92885250
64Estrogen signaling pathway_Homo sapiens_hsa049150.92210515
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92150360
66Taste transduction_Homo sapiens_hsa047420.91943103
67Choline metabolism in cancer_Homo sapiens_hsa052310.90693904
68VEGF signaling pathway_Homo sapiens_hsa043700.88714559
69AMPK signaling pathway_Homo sapiens_hsa041520.87498438
70Pancreatic cancer_Homo sapiens_hsa052120.87477001
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87444519
72ErbB signaling pathway_Homo sapiens_hsa040120.87332671
73Pancreatic secretion_Homo sapiens_hsa049720.87100443
74Prostate cancer_Homo sapiens_hsa052150.85704838
75Inositol phosphate metabolism_Homo sapiens_hsa005620.83409447
76PPAR signaling pathway_Homo sapiens_hsa033200.82985988
77ABC transporters_Homo sapiens_hsa020100.79918015
78Endometrial cancer_Homo sapiens_hsa052130.79160873
79Gap junction_Homo sapiens_hsa045400.79126438
80Phenylalanine metabolism_Homo sapiens_hsa003600.76986228
81Bile secretion_Homo sapiens_hsa049760.76699085
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76594659
83Mineral absorption_Homo sapiens_hsa049780.75694766
84Lysine degradation_Homo sapiens_hsa003100.75692657
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74545442
86Arginine biosynthesis_Homo sapiens_hsa002200.74206840
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74203535
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74187900
89Insulin signaling pathway_Homo sapiens_hsa049100.71839746
90p53 signaling pathway_Homo sapiens_hsa041150.71750631
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71389854
92Insulin resistance_Homo sapiens_hsa049310.70025215
93Colorectal cancer_Homo sapiens_hsa052100.69271107
94Platelet activation_Homo sapiens_hsa046110.68693191
95mTOR signaling pathway_Homo sapiens_hsa041500.68658804
96MAPK signaling pathway_Homo sapiens_hsa040100.66902427
97Viral myocarditis_Homo sapiens_hsa054160.65751735
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65617120
99Amphetamine addiction_Homo sapiens_hsa050310.65494361
100Arginine and proline metabolism_Homo sapiens_hsa003300.64796396
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64681579
102Sphingolipid metabolism_Homo sapiens_hsa006000.63223833
103Glucagon signaling pathway_Homo sapiens_hsa049220.63100559
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.62967461
105Chronic myeloid leukemia_Homo sapiens_hsa052200.61983508
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61007420
107Insulin secretion_Homo sapiens_hsa049110.60917697
108Fatty acid metabolism_Homo sapiens_hsa012120.60811419
109Type II diabetes mellitus_Homo sapiens_hsa049300.60544438
110HIF-1 signaling pathway_Homo sapiens_hsa040660.60320689
111Circadian rhythm_Homo sapiens_hsa047100.58255352
112Thyroid cancer_Homo sapiens_hsa052160.57180732
113Thyroid hormone synthesis_Homo sapiens_hsa049180.57169763
114HTLV-I infection_Homo sapiens_hsa051660.56778212
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55888280
116FoxO signaling pathway_Homo sapiens_hsa040680.55396418
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.55088273
118Toxoplasmosis_Homo sapiens_hsa051450.54868485
119Cholinergic synapse_Homo sapiens_hsa047250.54222484
120Pyruvate metabolism_Homo sapiens_hsa006200.52389882
121Serotonergic synapse_Homo sapiens_hsa047260.50778556
122Renal cell carcinoma_Homo sapiens_hsa052110.50200515
123Non-small cell lung cancer_Homo sapiens_hsa052230.47477632
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46364849
125Tyrosine metabolism_Homo sapiens_hsa003500.41972007
126Vitamin B6 metabolism_Homo sapiens_hsa007500.39794425

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