TAMM41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.45975251
2DNA strand elongation involved in DNA replication (GO:0006271)5.21819484
3DNA deamination (GO:0045006)5.17619825
4telomere maintenance via semi-conservative replication (GO:0032201)5.02726303
5DNA strand elongation (GO:0022616)4.96176542
6DNA replication initiation (GO:0006270)4.82151911
7maturation of SSU-rRNA (GO:0030490)4.68756533
8DNA replication checkpoint (GO:0000076)4.63836454
9DNA unwinding involved in DNA replication (GO:0006268)4.54482339
10telomere maintenance via recombination (GO:0000722)4.43223328
11viral transcription (GO:0019083)4.20404791
12mitotic recombination (GO:0006312)4.16155205
13translational termination (GO:0006415)4.14983112
14piRNA metabolic process (GO:0034587)4.14715786
15formation of translation preinitiation complex (GO:0001731)4.09304081
16CENP-A containing nucleosome assembly (GO:0034080)4.06936049
17protein complex biogenesis (GO:0070271)4.05048661
18ribosomal small subunit biogenesis (GO:0042274)4.04652698
19chromatin remodeling at centromere (GO:0031055)4.03903794
20nucleobase biosynthetic process (GO:0046112)4.02362248
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.98239401
22NADH dehydrogenase complex assembly (GO:0010257)3.98239401
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.98239401
24kinetochore organization (GO:0051383)3.96477524
25respiratory chain complex IV assembly (GO:0008535)3.93479038
26ribosomal large subunit biogenesis (GO:0042273)3.90569999
27telomere maintenance via telomere lengthening (GO:0010833)3.90332509
28purine nucleobase biosynthetic process (GO:0009113)3.89113807
29mitochondrial respiratory chain complex assembly (GO:0033108)3.85811684
30translational elongation (GO:0006414)3.82922379
31protein localization to kinetochore (GO:0034501)3.78865560
32nucleotide-excision repair, DNA gap filling (GO:0006297)3.78561560
33RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.77660860
34tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.77660860
35kinetochore assembly (GO:0051382)3.74589943
36ribonucleoprotein complex biogenesis (GO:0022613)3.73200111
37mitotic metaphase plate congression (GO:0007080)3.72288169
38deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.68612947
39proteasome assembly (GO:0043248)3.65895671
40IMP biosynthetic process (GO:0006188)3.63581914
41DNA replication-independent nucleosome assembly (GO:0006336)3.63180661
42DNA replication-independent nucleosome organization (GO:0034724)3.63180661
43SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.61301045
44translational initiation (GO:0006413)3.61081731
45ribosome biogenesis (GO:0042254)3.60606278
46protein neddylation (GO:0045116)3.58371227
47DNA replication-dependent nucleosome assembly (GO:0006335)3.57152523
48DNA replication-dependent nucleosome organization (GO:0034723)3.57152523
49DNA double-strand break processing (GO:0000729)3.56706496
50water-soluble vitamin biosynthetic process (GO:0042364)3.54255841
51spliceosomal snRNP assembly (GO:0000387)3.53940030
52cotranslational protein targeting to membrane (GO:0006613)3.52272834
53pseudouridine synthesis (GO:0001522)3.51964666
54mitotic nuclear envelope disassembly (GO:0007077)3.51429831
55protein targeting to ER (GO:0045047)3.49360701
56nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.47004845
57rRNA processing (GO:0006364)3.45250531
58folic acid-containing compound biosynthetic process (GO:0009396)3.44930443
59establishment of protein localization to mitochondrial membrane (GO:0090151)3.44666051
60replication fork processing (GO:0031297)3.43952083
61cytochrome complex assembly (GO:0017004)3.43885554
62regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.41322071
63establishment of integrated proviral latency (GO:0075713)3.38805109
64chaperone-mediated protein transport (GO:0072321)3.38724554
65metaphase plate congression (GO:0051310)3.35264034
66rRNA metabolic process (GO:0016072)3.32079901
67protein localization to endoplasmic reticulum (GO:0070972)3.31043389
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.30689963
69DNA methylation involved in gamete generation (GO:0043046)3.30285517
70viral mRNA export from host cell nucleus (GO:0046784)3.30067189
71protein localization to chromosome, centromeric region (GO:0071459)3.29367094
72protein polyglutamylation (GO:0018095)3.29291632
73establishment of protein localization to endoplasmic reticulum (GO:0072599)3.29254939
74viral life cycle (GO:0019058)3.27708531
75cellular protein complex disassembly (GO:0043624)3.27436230
76transcription-coupled nucleotide-excision repair (GO:0006283)3.24471350
77histone exchange (GO:0043486)3.24129218
78anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.23594126
79IMP metabolic process (GO:0046040)3.22568720
80nuclear envelope disassembly (GO:0051081)3.20815572
81membrane disassembly (GO:0030397)3.20815572
82regulation of double-strand break repair via homologous recombination (GO:0010569)3.20254286
83regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19935128
84translation (GO:0006412)3.18443291
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16610811
86cell cycle G1/S phase transition (GO:0044843)3.15874249
87G1/S transition of mitotic cell cycle (GO:0000082)3.15874249
88spliceosomal complex assembly (GO:0000245)3.15652413
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.14246787
90attachment of spindle microtubules to kinetochore (GO:0008608)3.12967154
91telomere organization (GO:0032200)3.11786504
92termination of RNA polymerase III transcription (GO:0006386)3.10600103
93transcription elongation from RNA polymerase III promoter (GO:0006385)3.10600103
94recombinational repair (GO:0000725)3.10202744
95telomere maintenance (GO:0000723)3.10072842
96rRNA modification (GO:0000154)3.09641234
97RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.09315484
98regulation of meiosis I (GO:0060631)3.08989027
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.08777708
100protein deneddylation (GO:0000338)3.08523719
101establishment of chromosome localization (GO:0051303)3.08390034
102peptidyl-histidine modification (GO:0018202)3.07786450
103energy coupled proton transport, down electrochemical gradient (GO:0015985)3.07221373
104ATP synthesis coupled proton transport (GO:0015986)3.07221373
105regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.06117037
106regulation of mitotic spindle checkpoint (GO:1903504)3.06117037
107mitotic chromosome condensation (GO:0007076)3.05520628
108double-strand break repair via homologous recombination (GO:0000724)3.02756053
109mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.02742842
110mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.02672794
111tRNA processing (GO:0008033)3.02400878
112negative regulation of ligase activity (GO:0051352)3.01725729
113negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.01725729
114synapsis (GO:0007129)3.00522867
115cullin deneddylation (GO:0010388)2.99988980
116deoxyribonucleotide biosynthetic process (GO:0009263)2.97447624
117protein complex disassembly (GO:0043241)2.97395126
118DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.96919678
119behavioral response to nicotine (GO:0035095)2.96573796
120ribosome assembly (GO:0042255)2.96373660
121cellular component biogenesis (GO:0044085)2.95439658
122epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.94739102
123intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.92731631
124signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.92731631
125nuclear-transcribed mRNA catabolic process (GO:0000956)2.92053467
126nuclear pore organization (GO:0006999)2.91326880
127protein-cofactor linkage (GO:0018065)2.91321612
128signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.90224331
129signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.90224331
130signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.90224331
131mannosylation (GO:0097502)2.88243736
132DNA duplex unwinding (GO:0032508)2.87797203
133DNA geometric change (GO:0032392)2.86945847
134regulation of nuclear cell cycle DNA replication (GO:0033262)2.86555263
135somatic diversification of immune receptors via somatic mutation (GO:0002566)2.86415670
136somatic hypermutation of immunoglobulin genes (GO:0016446)2.86415670
137signal transduction involved in DNA damage checkpoint (GO:0072422)2.85668733
138signal transduction involved in DNA integrity checkpoint (GO:0072401)2.85668733
139macromolecular complex disassembly (GO:0032984)2.85208751
140negative regulation of DNA-dependent DNA replication (GO:2000104)2.82650169
141platelet dense granule organization (GO:0060155)2.82362711
142centriole replication (GO:0007099)2.79397851
143response to pheromone (GO:0019236)2.79074273
144L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.78582114
145protein K6-linked ubiquitination (GO:0085020)2.78408712
146histone H2A acetylation (GO:0043968)2.76894356
147organelle disassembly (GO:1903008)2.75981550
148tRNA metabolic process (GO:0006399)2.69982886
149reciprocal meiotic recombination (GO:0007131)2.66683628
150reciprocal DNA recombination (GO:0035825)2.66683628
151tRNA modification (GO:0006400)2.65485655
152rRNA methylation (GO:0031167)2.65274597
153DNA catabolic process, exonucleolytic (GO:0000738)2.65241125
154intracellular protein transmembrane import (GO:0044743)2.64483313
155ribonucleoprotein complex disassembly (GO:0032988)2.62269334
156tachykinin receptor signaling pathway (GO:0007217)2.60583608
157nonmotile primary cilium assembly (GO:0035058)2.59964617
158mitochondrial RNA metabolic process (GO:0000959)2.58799224
159maturation of 5.8S rRNA (GO:0000460)2.58349566
160DNA demethylation (GO:0080111)2.57244825
161resolution of meiotic recombination intermediates (GO:0000712)2.56984538
162somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.56780588
163somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.56780588
164isotype switching (GO:0045190)2.56780588
165preassembly of GPI anchor in ER membrane (GO:0016254)2.56503444
166postreplication repair (GO:0006301)2.56212454
167histone mRNA metabolic process (GO:0008334)2.54910329
168detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.54445169
169maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.52709248
170ubiquinone biosynthetic process (GO:0006744)2.51069784
171electron transport chain (GO:0022900)2.50333067
172respiratory electron transport chain (GO:0022904)2.46456774
173keratinocyte development (GO:0003334)2.46111139
174male meiosis I (GO:0007141)2.45770840
175regulation of mitochondrial translation (GO:0070129)2.44877344
176regulation of cilium movement (GO:0003352)2.44247383
177epithelial cilium movement (GO:0003351)2.42957924
178fucose catabolic process (GO:0019317)2.41691486
179L-fucose metabolic process (GO:0042354)2.41691486
180L-fucose catabolic process (GO:0042355)2.41691486
181iron-sulfur cluster assembly (GO:0016226)2.41253570
182metallo-sulfur cluster assembly (GO:0031163)2.41253570
183ncRNA metabolic process (GO:0034660)2.40066230

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.59428030
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.53562567
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.07076810
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65045472
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45912378
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.38881155
7ZNF274_21170338_ChIP-Seq_K562_Hela3.28105148
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.18039795
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.11233723
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.09327052
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08900414
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.03595873
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.96381051
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.94775127
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.90345759
16IGF1R_20145208_ChIP-Seq_DFB_Human2.80137497
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.75679174
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70586776
19VDR_22108803_ChIP-Seq_LS180_Human2.69343770
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49839850
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.43366607
22XRN2_22483619_ChIP-Seq_HELA_Human2.41411113
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.41176193
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40342458
25VDR_23849224_ChIP-Seq_CD4+_Human2.35233245
26EWS_26573619_Chip-Seq_HEK293_Human2.23558112
27GBX2_23144817_ChIP-Seq_PC3_Human2.22533238
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17789050
29DCP1A_22483619_ChIP-Seq_HELA_Human2.15079980
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11836433
31FOXP3_21729870_ChIP-Seq_TREG_Human2.08157140
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06316470
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01732042
34GABP_19822575_ChIP-Seq_HepG2_Human2.01305050
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01225513
36E2F1_21310950_ChIP-Seq_MCF-7_Human2.00091389
37IRF1_19129219_ChIP-ChIP_H3396_Human1.99506270
38AR_21909140_ChIP-Seq_LNCAP_Human1.98978606
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98841075
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98001005
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96665243
42FUS_26573619_Chip-Seq_HEK293_Human1.94796050
43TTF2_22483619_ChIP-Seq_HELA_Human1.94599179
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93309377
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.87350099
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87133919
47EZH2_22144423_ChIP-Seq_EOC_Human1.86382968
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85937025
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84117800
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80639176
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79051368
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76063078
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69804346
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.67776360
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.67666943
56CIITA_25753668_ChIP-Seq_RAJI_Human1.67194140
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65884780
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63651458
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63384039
60TP53_22573176_ChIP-Seq_HFKS_Human1.62810577
61ELK1_19687146_ChIP-ChIP_HELA_Human1.62800844
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62794610
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61193919
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60629386
65P300_19829295_ChIP-Seq_ESCs_Human1.58650400
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57382242
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57340585
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56838172
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54833783
70TAF15_26573619_Chip-Seq_HEK293_Human1.53727442
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46092276
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44090115
73ER_23166858_ChIP-Seq_MCF-7_Human1.43698602
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42677148
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42572024
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39978757
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39787762
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39693479
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38403583
80KDM5A_27292631_Chip-Seq_BREAST_Human1.36166201
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33719051
82MYC_22102868_ChIP-Seq_BL_Human1.31471111
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31143828
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28587924
85CBP_20019798_ChIP-Seq_JUKART_Human1.24169636
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24169636
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23746024
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21361078
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21328833
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.19125401
91EGR1_19374776_ChIP-ChIP_THP-1_Human1.18929877
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14463051
93NANOG_19829295_ChIP-Seq_ESCs_Human1.13882736
94SOX2_19829295_ChIP-Seq_ESCs_Human1.13882736
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13379696
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11750697
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11545574
98EZH2_27294783_Chip-Seq_NPCs_Mouse1.11473273
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10142384
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10058253
101TP63_19390658_ChIP-ChIP_HaCaT_Human1.10021788
102KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09658667
103MYC_18940864_ChIP-ChIP_HL60_Human1.09450796
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09339120
105STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08574922
106TFEB_21752829_ChIP-Seq_HELA_Human1.07861365
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06961673
108SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06880176
109TCF4_23295773_ChIP-Seq_U87_Human1.06708559
110PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06595181
111AR_25329375_ChIP-Seq_VCAP_Human1.06546798
112FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06292178
113FOXA1_25329375_ChIP-Seq_VCAP_Human1.06292178
114SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06171018
115STAT3_23295773_ChIP-Seq_U87_Human1.05770453
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05461478
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05417793
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04876343
119KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04819621
120SMAD4_21799915_ChIP-Seq_A2780_Human1.03718336
121GATA3_21878914_ChIP-Seq_MCF-7_Human1.02301486
122POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01863533
123DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01702092
124AR_20517297_ChIP-Seq_VCAP_Human1.01596997
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01229425
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01229425
127SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00951955
128ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00871926
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00153786
130CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99651912
131CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99190228
132HOXB7_26014856_ChIP-Seq_BT474_Human0.98197769
133SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97874187
134BCAT_22108803_ChIP-Seq_LS180_Human0.97568809
135BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97523623
136PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97014212
137VDR_21846776_ChIP-Seq_THP-1_Human0.96071331
138RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95445325
139TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95414869
140NCOR_22424771_ChIP-Seq_293T_Human0.94918732
141FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94159232
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.94137617
143SPI1_23547873_ChIP-Seq_NB4_Human0.93826738
144TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93607124
145NFE2_27457419_Chip-Seq_LIVER_Mouse0.93421205
146AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93078285
147TCF4_22108803_ChIP-Seq_LS180_Human0.92923025
148NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92595301
149POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92183483
150ELK1_22589737_ChIP-Seq_MCF10A_Human0.89937154
151CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87278753
152CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85561722
153KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85388144
154HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80870467
155CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79720711
156CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79317364
157SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76868827
158FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73799832
159TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72812615
160OCT4_18692474_ChIP-Seq_MEFs_Mouse0.72738225
161IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.72605329
162NANOG_21062744_ChIP-ChIP_HESCs_Human0.71754440

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.37450206
2MP0010094_abnormal_chromosome_stability4.88298231
3MP0004957_abnormal_blastocyst_morpholog4.52696059
4MP0003111_abnormal_nucleus_morphology4.33933661
5MP0003077_abnormal_cell_cycle4.09978352
6MP0008057_abnormal_DNA_replication4.02325574
7MP0008058_abnormal_DNA_repair3.60178546
8MP0002396_abnormal_hematopoietic_system2.98138174
9MP0002102_abnormal_ear_morphology2.92556713
10MP0008007_abnormal_cellular_replicative2.86920933
11MP0008932_abnormal_embryonic_tissue2.77170057
12MP0000372_irregular_coat_pigmentation2.37597953
13MP0003123_paternal_imprinting2.32510936
14MP0003786_premature_aging2.21474751
15MP0005551_abnormal_eye_electrophysiolog2.21427216
16MP0000350_abnormal_cell_proliferation2.11638669
17MP0001730_embryonic_growth_arrest2.09335027
18MP0000490_abnormal_crypts_of2.03420915
19MP0004147_increased_porphyrin_level2.00595054
20MP0000569_abnormal_digit_pigmentation1.97440742
21MP0008877_abnormal_DNA_methylation1.97276174
22MP0002837_dystrophic_cardiac_calcinosis1.89757788
23MP0005379_endocrine/exocrine_gland_phen1.88150394
24MP0010030_abnormal_orbit_morphology1.77848565
25MP0003195_calcinosis1.75279077
26MP0003880_abnormal_central_pattern1.75246000
27MP0003787_abnormal_imprinting1.74943453
28MP0003136_yellow_coat_color1.74872191
29MP0004142_abnormal_muscle_tone1.73736088
30MP0006072_abnormal_retinal_apoptosis1.71771993
31MP0010352_gastrointestinal_tract_polyps1.70677635
32MP0001986_abnormal_taste_sensitivity1.66707201
33MP0002163_abnormal_gland_morphology1.65338078
34MP0008872_abnormal_physiological_respon1.62639320
35MP0006054_spinal_hemorrhage1.61427691
36MP0001697_abnormal_embryo_size1.61037612
37MP0003806_abnormal_nucleotide_metabolis1.59924889
38MP0006292_abnormal_olfactory_placode1.57250022
39MP0003646_muscle_fatigue1.56563115
40MP0001529_abnormal_vocalization1.56419733
41MP0001293_anophthalmia1.56105537
42MP0005646_abnormal_pituitary_gland1.56096342
43MP0009046_muscle_twitch1.55816851
44MP0000313_abnormal_cell_death1.55351684
45MP0000427_abnormal_hair_cycle1.52386336
46MP0005075_abnormal_melanosome_morpholog1.52257030
47MP0005380_embryogenesis_phenotype1.52227718
48MP0001672_abnormal_embryogenesis/_devel1.52227718
49MP0009379_abnormal_foot_pigmentation1.51659955
50MP0004808_abnormal_hematopoietic_stem1.50947182
51MP0005253_abnormal_eye_physiology1.50157893
52MP0002736_abnormal_nociception_after1.49943545
53MP0002080_prenatal_lethality1.49359745
54MP0003763_abnormal_thymus_physiology1.45962517
55MP0005397_hematopoietic_system_phenotyp1.45487671
56MP0001545_abnormal_hematopoietic_system1.45487671
57MP0001968_abnormal_touch/_nociception1.44825529
58MP0000631_abnormal_neuroendocrine_gland1.44617877
59MP0009333_abnormal_splenocyte_physiolog1.42309344
60MP0002019_abnormal_tumor_incidence1.40772993
61MP0003984_embryonic_growth_retardation1.36943167
62MP0008875_abnormal_xenobiotic_pharmacok1.35769018
63MP0002234_abnormal_pharynx_morphology1.35239402
64MP0006276_abnormal_autonomic_nervous1.34961777
65MP0002088_abnormal_embryonic_growth/wei1.33494411
66MP0003186_abnormal_redox_activity1.32264053
67MP0002085_abnormal_embryonic_tissue1.30451198
68MP0002210_abnormal_sex_determination1.29503177
69MP0004742_abnormal_vestibular_system1.27955452
70MP0003718_maternal_effect1.25662094
71MP0002272_abnormal_nervous_system1.25125433
72MP0005645_abnormal_hypothalamus_physiol1.23936244
73MP0002132_abnormal_respiratory_system1.22034745
74MP0000383_abnormal_hair_follicle1.21952471
75MP0009745_abnormal_behavioral_response1.21712292
76MP0003567_abnormal_fetal_cardiomyocyte1.21602862
77MP0002653_abnormal_ependyma_morphology1.21258534
78MP0002398_abnormal_bone_marrow1.19601965
79MP0003121_genomic_imprinting1.17522072
80MP0001485_abnormal_pinna_reflex1.17433774
81MP0006036_abnormal_mitochondrial_physio1.15925564
82MP0002086_abnormal_extraembryonic_tissu1.13936043
83MP0000703_abnormal_thymus_morphology1.12892210
84MP0000689_abnormal_spleen_morphology1.12406663
85MP0002084_abnormal_developmental_patter1.11402860
86MP0001145_abnormal_male_reproductive1.11378123
87MP0004043_abnormal_pH_regulation1.10923063
88MP0000647_abnormal_sebaceous_gland1.10042718
89MP0002722_abnormal_immune_system1.09960738
90MP0010307_abnormal_tumor_latency1.09537782
91MP0003315_abnormal_perineum_morphology1.09155621
92MP0005394_taste/olfaction_phenotype1.09076908
93MP0005499_abnormal_olfactory_system1.09076908
94MP0003890_abnormal_embryonic-extraembry1.08363460
95MP0002735_abnormal_chemical_nociception1.08322643
96MP0005174_abnormal_tail_pigmentation1.07196647
97MP0004885_abnormal_endolymph1.04032564
98MP0002751_abnormal_autonomic_nervous1.03681586
99MP0004197_abnormal_fetal_growth/weight/1.03136527
100MP0002638_abnormal_pupillary_reflex1.02234933
101MP0000358_abnormal_cell_content/1.00691667
102MP0001984_abnormal_olfaction1.00161527
103MP0002160_abnormal_reproductive_system0.99818203
104MP0006035_abnormal_mitochondrial_morpho0.99669670
105MP0004145_abnormal_muscle_electrophysio0.99328465
106MP0003656_abnormal_erythrocyte_physiolo0.98257879
107MP0002938_white_spotting0.98083887
108MP0003698_abnormal_male_reproductive0.97686253
109MP0005187_abnormal_penis_morphology0.95150092
110MP0002429_abnormal_blood_cell0.93524406
111MP0000653_abnormal_sex_gland0.92547898
112MP0001929_abnormal_gametogenesis0.92511573
113MP0001853_heart_inflammation0.92397360
114MP0003937_abnormal_limbs/digits/tail_de0.91572544
115MP0005423_abnormal_somatic_nervous0.91425573
116MP0009697_abnormal_copulation0.89006027
117MP0002095_abnormal_skin_pigmentation0.88615006
118MP0001486_abnormal_startle_reflex0.88100020
119MP0005084_abnormal_gallbladder_morpholo0.87030392
120MP0004133_heterotaxia0.86787246
121MP0005395_other_phenotype0.85428243
122MP0001324_abnormal_eye_pigmentation0.83123990
123MP0002876_abnormal_thyroid_physiology0.81999100
124MP0000516_abnormal_urinary_system0.80692914
125MP0005367_renal/urinary_system_phenotyp0.80692914
126MP0001119_abnormal_female_reproductive0.80581036
127MP0000537_abnormal_urethra_morphology0.79993864
128MP0008775_abnormal_heart_ventricle0.79918617
129MP0001501_abnormal_sleep_pattern0.78712887
130MP0003221_abnormal_cardiomyocyte_apopto0.77890093
131MP0005410_abnormal_fertilization0.75585857
132MP0002233_abnormal_nose_morphology0.75404520
133MP0002067_abnormal_sensory_capabilities0.74898915
134MP0005670_abnormal_white_adipose0.74892468
135MP0002928_abnormal_bile_duct0.74431551
136MP0000716_abnormal_immune_system0.74169507
137MP0005389_reproductive_system_phenotype0.73717321
138MP0003941_abnormal_skin_development0.73519233
139MP0009053_abnormal_anal_canal0.71542884
140MP0000858_altered_metastatic_potential0.69377586
141MP0005384_cellular_phenotype0.68117802
142MP0000015_abnormal_ear_pigmentation0.67887780
143MP0008789_abnormal_olfactory_epithelium0.66998748
144MP0003119_abnormal_digestive_system0.66973665
145MP0002075_abnormal_coat/hair_pigmentati0.66665259
146MP0000477_abnormal_intestine_morphology0.66636703
147MP0000049_abnormal_middle_ear0.65547909
148MP0001915_intracranial_hemorrhage0.64977504
149MP0005266_abnormal_metabolism0.62363799
150MP0008995_early_reproductive_senescence0.62111131
151MP0001835_abnormal_antigen_presentation0.58564069
152MP0001286_abnormal_eye_development0.58244505
153MP0003943_abnormal_hepatobiliary_system0.57535540
154MP0002111_abnormal_tail_morphology0.57510142
155MP0009672_abnormal_birth_weight0.56268630
156MP0001186_pigmentation_phenotype0.55275909
157MP0003942_abnormal_urinary_system0.55269618
158MP0002405_respiratory_system_inflammati0.54068358
159MP0001764_abnormal_homeostasis0.54041945
160MP0002420_abnormal_adaptive_immunity0.52291864
161MP0005671_abnormal_response_to0.50580627
162MP0001819_abnormal_immune_cell0.50567514

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.15488511
2Abnormal number of erythroid precursors (HP:0012131)5.15482775
3Reticulocytopenia (HP:0001896)4.87602548
4Birth length less than 3rd percentile (HP:0003561)4.78215023
5Pancreatic cysts (HP:0001737)3.90742926
6Aplastic anemia (HP:0001915)3.85429551
7Pancreatic fibrosis (HP:0100732)3.61406941
8Oral leukoplakia (HP:0002745)3.58547676
9Breast hypoplasia (HP:0003187)3.58208988
10Chromsome breakage (HP:0040012)3.57689211
11Selective tooth agenesis (HP:0001592)3.49107043
12Abnormality of midbrain morphology (HP:0002418)3.37291992
13Molar tooth sign on MRI (HP:0002419)3.37291992
14Colon cancer (HP:0003003)3.37053876
15Abnormality of the heme biosynthetic pathway (HP:0010472)3.30264340
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.25859111
17Patellar aplasia (HP:0006443)3.20376361
18Pallor (HP:0000980)3.18939517
19Degeneration of anterior horn cells (HP:0002398)3.12053101
20Abnormality of the anterior horn cell (HP:0006802)3.12053101
21Abnormal lung lobation (HP:0002101)3.11463493
22Macrocytic anemia (HP:0001972)3.07233002
23Acute encephalopathy (HP:0006846)3.05627746
24True hermaphroditism (HP:0010459)3.02752169
25Aplasia/Hypoplasia of the sacrum (HP:0008517)3.02294966
26Aplasia/Hypoplasia of the patella (HP:0006498)2.98049170
27Medial flaring of the eyebrow (HP:0010747)2.94095559
28Nephronophthisis (HP:0000090)2.93734500
29Meckel diverticulum (HP:0002245)2.89498148
30Abnormality of chromosome stability (HP:0003220)2.88341605
31Abnormality of the ileum (HP:0001549)2.87714101
32Cerebral hypomyelination (HP:0006808)2.85196132
3311 pairs of ribs (HP:0000878)2.82483221
34Abnormality of the preputium (HP:0100587)2.82413701
35Progressive macrocephaly (HP:0004481)2.81990062
36Microretrognathia (HP:0000308)2.79815896
37Carpal bone hypoplasia (HP:0001498)2.76200801
38Rough bone trabeculation (HP:0100670)2.75154512
39Medulloblastoma (HP:0002885)2.70840153
40Premature graying of hair (HP:0002216)2.70759886
41Abnormal number of incisors (HP:0011064)2.65547263
42Type I transferrin isoform profile (HP:0003642)2.60965999
43Myelodysplasia (HP:0002863)2.59352442
44Absent thumb (HP:0009777)2.58951939
45Renal Fanconi syndrome (HP:0001994)2.58512950
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.57690237
47Hepatocellular necrosis (HP:0001404)2.55353286
48Abnormality of the renal medulla (HP:0100957)2.54754130
49Congenital stationary night blindness (HP:0007642)2.51310877
50Increased serum lactate (HP:0002151)2.50611325
51Abnormality of the labia minora (HP:0012880)2.47514074
52Cellular immunodeficiency (HP:0005374)2.47059328
53Thrombocytosis (HP:0001894)2.45225630
54Decreased activity of mitochondrial respiratory chain (HP:0008972)2.42082307
55Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.42082307
56Small intestinal stenosis (HP:0012848)2.42067309
57Duodenal stenosis (HP:0100867)2.42067309
58Abnormality of the renal cortex (HP:0011035)2.38625724
59Bone marrow hypocellularity (HP:0005528)2.37234138
60Cleft eyelid (HP:0000625)2.37227744
61IgM deficiency (HP:0002850)2.37173261
62Abnormality of reticulocytes (HP:0004312)2.36372755
63Pancytopenia (HP:0001876)2.34717015
64Trismus (HP:0000211)2.34679830
65Facial cleft (HP:0002006)2.34663545
66Congenital primary aphakia (HP:0007707)2.33306702
67Agnosia (HP:0010524)2.33299621
68Increased CSF lactate (HP:0002490)2.30912315
69Gait imbalance (HP:0002141)2.28985893
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28889875
71Abnormality of alanine metabolism (HP:0010916)2.28889875
72Hyperalaninemia (HP:0003348)2.28889875
73Nephrogenic diabetes insipidus (HP:0009806)2.25984421
74Hyperventilation (HP:0002883)2.25929901
75Type II lissencephaly (HP:0007260)2.24597642
76Mitochondrial inheritance (HP:0001427)2.22660328
77Hepatic necrosis (HP:0002605)2.22408397
78Ectopic kidney (HP:0000086)2.21482369
79Methylmalonic acidemia (HP:0002912)2.21345899
80Neoplasm of the pancreas (HP:0002894)2.20564127
81Cerebral edema (HP:0002181)2.20504798
82Atresia of the external auditory canal (HP:0000413)2.19828390
83Multiple enchondromatosis (HP:0005701)2.18508947
84Premature ovarian failure (HP:0008209)2.17943916
85Increased hepatocellular lipid droplets (HP:0006565)2.17914089
86Ependymoma (HP:0002888)2.16856122
87Nephroblastoma (Wilms tumor) (HP:0002667)2.16843061
88Sclerocornea (HP:0000647)2.16280517
89Aplasia/Hypoplasia of the tongue (HP:0010295)2.15806334
90Aplasia/Hypoplasia of the sternum (HP:0006714)2.15205125
91Cystic liver disease (HP:0006706)2.14288590
92Triphalangeal thumb (HP:0001199)2.14084906
93Sloping forehead (HP:0000340)2.11621314
94Progressive microcephaly (HP:0000253)2.11354259
95Hyperglycinemia (HP:0002154)2.10584695
96Attenuation of retinal blood vessels (HP:0007843)2.10122854
97Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07279903
98Hypoplasia of the pons (HP:0012110)2.07133429
99Abnormality of the pons (HP:0007361)2.06570909
100Lymphoma (HP:0002665)2.06387182
101Acute necrotizing encephalopathy (HP:0006965)2.06138914
102Tubular atrophy (HP:0000092)2.05757189
103Genital tract atresia (HP:0001827)2.05454260
104Optic disc pallor (HP:0000543)2.04249604
105Exertional dyspnea (HP:0002875)2.03983466
106Aplasia/Hypoplasia of the spleen (HP:0010451)2.03910668
107Bile duct proliferation (HP:0001408)2.03726460
108Abnormal biliary tract physiology (HP:0012439)2.03726460
109Rhabdomyosarcoma (HP:0002859)2.03319364
110Abnormal spermatogenesis (HP:0008669)2.03121133
111Absent radius (HP:0003974)2.02917232
112Inability to walk (HP:0002540)2.02513502
113Lactic acidosis (HP:0003128)2.02034859
114Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.01287193
115Aplasia/Hypoplasia of the tibia (HP:0005772)2.00862641
116Embryonal renal neoplasm (HP:0011794)2.00719315
117Respiratory difficulties (HP:0002880)2.00709155
118Gaze-evoked nystagmus (HP:0000640)2.00673686
119Supernumerary spleens (HP:0009799)2.00266762
120Methylmalonic aciduria (HP:0012120)1.99223715
121Increased intramyocellular lipid droplets (HP:0012240)1.98678646
122Cerebellar dysplasia (HP:0007033)1.97213888
123Vaginal atresia (HP:0000148)1.95814634
124Abnormal trabecular bone morphology (HP:0100671)1.93947532
125Tracheoesophageal fistula (HP:0002575)1.93799113
126Poor head control (HP:0002421)1.93617778
1273-Methylglutaconic aciduria (HP:0003535)1.92850455
128Abnormal mitochondria in muscle tissue (HP:0008316)1.92768489
129Microvesicular hepatic steatosis (HP:0001414)1.92414310
130Anencephaly (HP:0002323)1.92373280
131Increased serum pyruvate (HP:0003542)1.91466337
132Abnormality of glycolysis (HP:0004366)1.91466337
133Preaxial hand polydactyly (HP:0001177)1.91295279
134Lipid accumulation in hepatocytes (HP:0006561)1.91002092
135Reduced antithrombin III activity (HP:0001976)1.90655262
136Abnormality of the duodenum (HP:0002246)1.89890986
137Postaxial foot polydactyly (HP:0001830)1.89530797
138Abnormality of the renal collecting system (HP:0004742)1.89495400
139Chronic hepatic failure (HP:0100626)1.89427496
140Renal cortical cysts (HP:0000803)1.88746924
141Small hand (HP:0200055)1.88255137
142Duplicated collecting system (HP:0000081)1.87395189
143Atrophy/Degeneration involving motor neurons (HP:0007373)1.86756814
144Neoplasm of the colon (HP:0100273)1.85772621
145Secondary amenorrhea (HP:0000869)1.85655819
146Abolished electroretinogram (ERG) (HP:0000550)1.85153700
147Aplasia involving forearm bones (HP:0009822)1.84969275
148Absent forearm bone (HP:0003953)1.84969275
149Clubbing of toes (HP:0100760)1.82633158
150Hyperglycinuria (HP:0003108)1.82535558
151Asplenia (HP:0001746)1.82284317
152Horseshoe kidney (HP:0000085)1.82243592
153Optic nerve coloboma (HP:0000588)1.81931302
154Broad-based gait (HP:0002136)1.81355445
155Neoplasm of the adrenal cortex (HP:0100641)1.80994162
156Progressive inability to walk (HP:0002505)1.80466166
157Glossoptosis (HP:0000162)1.80206684
158Abnormal protein glycosylation (HP:0012346)1.79407770
159Abnormal glycosylation (HP:0012345)1.79407770
160Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79407770
161Abnormal protein N-linked glycosylation (HP:0012347)1.79407770
162Bifid tongue (HP:0010297)1.76983673
163Abnormality of DNA repair (HP:0003254)1.76215100
164Pendular nystagmus (HP:0012043)1.75793921
165Abnormality of glycine metabolism (HP:0010895)1.74494683
166Abnormality of serine family amino acid metabolism (HP:0010894)1.74494683
167Abnormal drinking behavior (HP:0030082)1.74305817

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.46994062
2BUB14.44261849
3CDC74.43898442
4FRK3.88977703
5EIF2AK13.31406496
6NUAK13.18671463
7BMPR1B2.84613734
8ACVR1B2.73644642
9MAP4K22.69760372
10NME22.63027319
11TLK12.51832762
12SRPK12.50018962
13BRSK22.49174094
14PLK42.47199190
15VRK12.42364628
16EIF2AK32.35050972
17VRK22.32737598
18ADRBK22.31893964
19STK162.29957347
20TTK2.16466218
21GRK12.06604810
22TESK22.04733283
23TRIM282.02955930
24NEK22.02066599
25WNK31.96627650
26PLK11.90084082
27TSSK61.83782954
28WNK41.78288274
29BRSK11.74055507
30CDK71.73900693
31ATR1.70030142
32NEK11.67853818
33CASK1.64795131
34MKNK11.62074350
35AURKB1.61552676
36RPS6KB21.60336380
37PASK1.50463725
38MAPK131.46013810
39TAOK31.45040841
40CHEK21.40140472
41TGFBR11.37236515
42INSRR1.37146412
43MAP3K41.34955123
44CCNB11.33070129
45RPS6KA41.32391126
46ZAK1.31875134
47PLK31.28105282
48PLK21.26658344
49KDR1.25468669
50STK391.24507201
51AURKA1.23972705
52CDK81.21339543
53MAP3K81.15289458
54CDK41.14979048
55MAP3K111.12348511
56MAP4K11.11420605
57TIE11.08302295
58CHEK11.06570707
59STK101.05962249
60BLK1.05807449
61DYRK31.04540998
62CSNK1G11.02953985
63SCYL21.02644816
64CSNK1G21.02436283
65TESK10.98404016
66CSNK1G30.98001789
67OXSR10.95314703
68STK40.94838504
69PBK0.88871399
70PNCK0.85210811
71CSNK1A1L0.84313675
72PAK40.83213937
73PIM20.81784963
74LATS10.81604664
75TAF10.81382934
76MAP2K30.79887531
77BCKDK0.79406880
78ATM0.78600050
79EIF2AK20.78230921
80NME10.75769277
81MAP3K100.74430748
82CLK10.73925236
83MAP2K70.73789530
84CSNK2A10.73583027
85MKNK20.73219451
86PIM10.72627408
87EPHA20.72268351
88PRKCG0.71841561
89STK30.71449652
90BCR0.70981153
91CDK20.70182720
92TNK20.69890613
93FLT30.69308567
94STK38L0.69228461
95PINK10.66365984
96CSNK2A20.66262335
97BTK0.66134676
98PIK3CA0.63211034
99LRRK20.63197971
100TXK0.63063415
101TNIK0.61447508
102PAK10.61217330
103BRAF0.59716692
104ADRBK10.59325766
105PAK30.58973460
106PDK20.58659494
107PRKCE0.56714810
108LIMK10.56045586
109MAPKAPK30.51453533
110CDK10.50268718
111TEC0.50101441
112CDK30.50082349
113CDK120.49682750
114EEF2K0.49307510
115CAMKK20.48042513
116MAPKAPK50.46186199
117DYRK20.46026257
118SIK30.44763432
119YES10.44139613
120CAMK2A0.43646043
121PRKCI0.42568487
122ILK0.42338598
123RPS6KA50.41441117
124FGFR20.41279656
125PKN10.40720515
126ZAP700.40443669
127TAOK20.40247154
128KIT0.40184656
129DAPK10.40084822
130CSNK1D0.39092055
131PRKCQ0.37272110
132CSNK1A10.36580985
133CAMK10.35547973
134IRAK40.35454541
135NTRK30.34211698
136STK240.34132958
137TYK20.33894853
138CDK190.33639112
139GRK50.33224730
140AKT20.32512930
141JAK30.32492714
142MUSK0.32462274
143MAP2K60.31001445
144PRKACA0.29199355
145GRK60.28508994
146CSF1R0.28330094
147MELK0.27995719
148MAP3K30.27515475
149ABL20.27344155
150EPHA40.27134022
151CDK60.25150598
152MARK30.23483813
153MST40.23331021
154LYN0.23254470
155RPS6KB10.22180630

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.29482710
2Mismatch repair_Homo sapiens_hsa034304.40564559
3Ribosome_Homo sapiens_hsa030104.03574957
4Proteasome_Homo sapiens_hsa030503.64706414
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.45123266
6Homologous recombination_Homo sapiens_hsa034403.26748276
7Base excision repair_Homo sapiens_hsa034103.24392596
8Spliceosome_Homo sapiens_hsa030403.21952258
9RNA polymerase_Homo sapiens_hsa030202.99898805
10Nucleotide excision repair_Homo sapiens_hsa034202.94633450
11RNA transport_Homo sapiens_hsa030132.76892132
12Pyrimidine metabolism_Homo sapiens_hsa002402.56417007
13Cell cycle_Homo sapiens_hsa041102.45342430
14One carbon pool by folate_Homo sapiens_hsa006702.44020513
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34154634
16Fanconi anemia pathway_Homo sapiens_hsa034602.12255143
17Non-homologous end-joining_Homo sapiens_hsa034502.12012106
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.08848937
19RNA degradation_Homo sapiens_hsa030181.96321926
20Basal transcription factors_Homo sapiens_hsa030221.86862399
21Phototransduction_Homo sapiens_hsa047441.84115389
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73509189
23Butanoate metabolism_Homo sapiens_hsa006501.69066253
24Propanoate metabolism_Homo sapiens_hsa006401.63993903
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53790267
26Regulation of autophagy_Homo sapiens_hsa041401.52467165
27mRNA surveillance pathway_Homo sapiens_hsa030151.39701879
28Nitrogen metabolism_Homo sapiens_hsa009101.38350037
29Purine metabolism_Homo sapiens_hsa002301.37166478
30Parkinsons disease_Homo sapiens_hsa050121.33708754
31p53 signaling pathway_Homo sapiens_hsa041151.33507650
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30503876
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29519227
34Linoleic acid metabolism_Homo sapiens_hsa005911.26561811
35Huntingtons disease_Homo sapiens_hsa050161.18665292
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13088817
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12159741
38Oxidative phosphorylation_Homo sapiens_hsa001901.10826923
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10472162
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07068498
41Epstein-Barr virus infection_Homo sapiens_hsa051691.06300629
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06146830
43Nicotine addiction_Homo sapiens_hsa050331.04535689
44Protein export_Homo sapiens_hsa030601.03982582
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02160831
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01737635
47Systemic lupus erythematosus_Homo sapiens_hsa053221.00050560
48Fatty acid elongation_Homo sapiens_hsa000620.99725280
49Peroxisome_Homo sapiens_hsa041460.99136215
50Tryptophan metabolism_Homo sapiens_hsa003800.99015216
51Ether lipid metabolism_Homo sapiens_hsa005650.95526764
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94841210
53Herpes simplex infection_Homo sapiens_hsa051680.91199665
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89186432
55Folate biosynthesis_Homo sapiens_hsa007900.84940055
56Caffeine metabolism_Homo sapiens_hsa002320.83471062
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.82069207
58Taste transduction_Homo sapiens_hsa047420.79131167
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.78364097
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77998744
61Olfactory transduction_Homo sapiens_hsa047400.77100209
62Oocyte meiosis_Homo sapiens_hsa041140.74585621
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73488338
64Pentose phosphate pathway_Homo sapiens_hsa000300.72722297
65beta-Alanine metabolism_Homo sapiens_hsa004100.71710205
66Sulfur relay system_Homo sapiens_hsa041220.71112497
67Viral carcinogenesis_Homo sapiens_hsa052030.70288527
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.70163793
69Steroid biosynthesis_Homo sapiens_hsa001000.68857099
70Antigen processing and presentation_Homo sapiens_hsa046120.68459980
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.68321177
72Thyroid cancer_Homo sapiens_hsa052160.67190109
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66441055
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66118489
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65036808
76Biosynthesis of amino acids_Homo sapiens_hsa012300.63820289
77Glutathione metabolism_Homo sapiens_hsa004800.63002929
78Primary immunodeficiency_Homo sapiens_hsa053400.61786435
79Chemical carcinogenesis_Homo sapiens_hsa052040.61392902
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61292155
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.61017773
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59885024
83Selenocompound metabolism_Homo sapiens_hsa004500.59724890
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58442287
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57111945
86Alzheimers disease_Homo sapiens_hsa050100.56567762
87HTLV-I infection_Homo sapiens_hsa051660.56558635
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55720839
89N-Glycan biosynthesis_Homo sapiens_hsa005100.55412955
90Sulfur metabolism_Homo sapiens_hsa009200.53454082
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51846525
92Galactose metabolism_Homo sapiens_hsa000520.51115474
93Pyruvate metabolism_Homo sapiens_hsa006200.50764841
94ABC transporters_Homo sapiens_hsa020100.50645651
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49678296
96Collecting duct acid secretion_Homo sapiens_hsa049660.49208413
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.48378138
98Legionellosis_Homo sapiens_hsa051340.47880702
99Fat digestion and absorption_Homo sapiens_hsa049750.47644678
100Carbon metabolism_Homo sapiens_hsa012000.47088057
101Fructose and mannose metabolism_Homo sapiens_hsa000510.45705479
102Asthma_Homo sapiens_hsa053100.44704009
103Morphine addiction_Homo sapiens_hsa050320.44433147
104Glycerolipid metabolism_Homo sapiens_hsa005610.44323200
105Fatty acid metabolism_Homo sapiens_hsa012120.44092422
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43246140
107Fatty acid degradation_Homo sapiens_hsa000710.42358188
108Retinol metabolism_Homo sapiens_hsa008300.41938362
109Measles_Homo sapiens_hsa051620.38616069
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37671292
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36573950
112Apoptosis_Homo sapiens_hsa042100.36031285
113Metabolic pathways_Homo sapiens_hsa011000.33125411
114Small cell lung cancer_Homo sapiens_hsa052220.31353912
115Shigellosis_Homo sapiens_hsa051310.31119416
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30755407
117Alcoholism_Homo sapiens_hsa050340.29126977
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29052852
119Lysine degradation_Homo sapiens_hsa003100.28735179
120MicroRNAs in cancer_Homo sapiens_hsa052060.27635597
121Arachidonic acid metabolism_Homo sapiens_hsa005900.27086934
122Serotonergic synapse_Homo sapiens_hsa047260.25748777
123TGF-beta signaling pathway_Homo sapiens_hsa043500.25261413
124Influenza A_Homo sapiens_hsa051640.24813959
125Basal cell carcinoma_Homo sapiens_hsa052170.24738488
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24526173
127GABAergic synapse_Homo sapiens_hsa047270.24450960
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23853917
129Hepatitis B_Homo sapiens_hsa051610.23690681
130HIF-1 signaling pathway_Homo sapiens_hsa040660.23511320
131Vitamin digestion and absorption_Homo sapiens_hsa049770.22092685
132Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.21901526
133Hematopoietic cell lineage_Homo sapiens_hsa046400.19761861
134Colorectal cancer_Homo sapiens_hsa052100.19608962
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18260618
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17991646
137Cardiac muscle contraction_Homo sapiens_hsa042600.17048392
138Hippo signaling pathway_Homo sapiens_hsa043900.16905028
139Bladder cancer_Homo sapiens_hsa052190.15777273
140Notch signaling pathway_Homo sapiens_hsa043300.15755109
141Acute myeloid leukemia_Homo sapiens_hsa052210.15479939
142Intestinal immune network for IgA production_Homo sapiens_hsa046720.15140874
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.13795387
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.11337755
145NF-kappa B signaling pathway_Homo sapiens_hsa040640.11216478
146Vitamin B6 metabolism_Homo sapiens_hsa007500.10630511
147Pathways in cancer_Homo sapiens_hsa052000.09053229
148Viral myocarditis_Homo sapiens_hsa054160.08508082
149Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.06682593
150NOD-like receptor signaling pathway_Homo sapiens_hsa046210.04825258
151Renin-angiotensin system_Homo sapiens_hsa046140.03882026
152SNARE interactions in vesicular transport_Homo sapiens_hsa041300.02067107

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