TAF9B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.38907683
2central nervous system myelination (GO:0022010)5.38907683
3neuron cell-cell adhesion (GO:0007158)5.16673109
4presynaptic membrane assembly (GO:0097105)4.84042199
5negative regulation of neurotransmitter secretion (GO:0046929)4.73264952
6negative regulation of neurotransmitter transport (GO:0051589)4.65677122
7presynaptic membrane organization (GO:0097090)4.53787070
8proteasome assembly (GO:0043248)4.18088120
9chromatin remodeling at centromere (GO:0031055)4.12715896
10DNA double-strand break processing (GO:0000729)4.10957432
11cullin deneddylation (GO:0010388)4.05013795
12CENP-A containing nucleosome assembly (GO:0034080)4.04576800
13regulation of synaptic vesicle exocytosis (GO:2000300)4.02400434
14synaptic vesicle exocytosis (GO:0016079)3.90616137
15fatty acid elongation (GO:0030497)3.70468044
16synapsis (GO:0007129)3.69594392
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.64764876
18kinetochore organization (GO:0051383)3.59784109
19protein deneddylation (GO:0000338)3.58797708
20regulation of mitotic spindle checkpoint (GO:1903504)3.55666380
21regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.55666380
22histone exchange (GO:0043486)3.52946959
23metaphase plate congression (GO:0051310)3.50762499
24response to redox state (GO:0051775)3.45565159
25myelination (GO:0042552)3.44273070
26positive regulation of meiosis (GO:0045836)3.42136345
27regulation of centriole replication (GO:0046599)3.41415160
28regulation of synaptic vesicle transport (GO:1902803)3.40619869
29glutamate secretion (GO:0014047)3.40454721
30kinetochore assembly (GO:0051382)3.39501533
31axon ensheathment (GO:0008366)3.39237271
32ensheathment of neurons (GO:0007272)3.39237271
33neuronal action potential propagation (GO:0019227)3.38406157
34piRNA metabolic process (GO:0034587)3.37139888
35long-chain fatty acid biosynthetic process (GO:0042759)3.36147287
36mitotic metaphase plate congression (GO:0007080)3.33872068
37mitotic sister chromatid cohesion (GO:0007064)3.32436625
38neurotransmitter-gated ion channel clustering (GO:0072578)3.29994590
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.29840288
40postsynaptic membrane organization (GO:0001941)3.28726937
41negative regulation of DNA-dependent DNA replication (GO:2000104)3.22715472
42DNA ligation (GO:0006266)3.21384770
43oligodendrocyte differentiation (GO:0048709)3.16135434
44replication fork processing (GO:0031297)3.14056821
45protein localization to kinetochore (GO:0034501)3.12774513
46regulation of short-term neuronal synaptic plasticity (GO:0048172)3.11094859
47synaptic vesicle docking involved in exocytosis (GO:0016081)3.09516193
48long-term synaptic potentiation (GO:0060291)3.08520243
49eye photoreceptor cell differentiation (GO:0001754)3.08007336
50photoreceptor cell differentiation (GO:0046530)3.08007336
51regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.06900932
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.05493329
53positive regulation of meiotic cell cycle (GO:0051446)3.05163238
54regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.05074960
55synaptic vesicle maturation (GO:0016188)3.05057368
56DNA replication checkpoint (GO:0000076)3.04503318
57establishment of integrated proviral latency (GO:0075713)3.02850290
58resolution of meiotic recombination intermediates (GO:0000712)3.02113065
59DNA replication-independent nucleosome organization (GO:0034724)3.01444815
60DNA replication-independent nucleosome assembly (GO:0006336)3.01444815
61spindle checkpoint (GO:0031577)3.00864725
62startle response (GO:0001964)3.00693469
63cerebellar granule cell differentiation (GO:0021707)2.99497237
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.99351822
65positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.96720892
66non-recombinational repair (GO:0000726)2.95430631
67double-strand break repair via nonhomologous end joining (GO:0006303)2.95430631
68nucleotide-excision repair, DNA gap filling (GO:0006297)2.95312904
69negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.94616857
70negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93590107
71mitotic spindle checkpoint (GO:0071174)2.93386182
72regulation of amyloid precursor protein catabolic process (GO:1902991)2.92627008
73glycerophospholipid catabolic process (GO:0046475)2.92323296
74regulation of collateral sprouting (GO:0048670)2.91026972
75regulation of beta-amyloid formation (GO:1902003)2.90319027
76postreplication repair (GO:0006301)2.89798728
77DNA catabolic process, exonucleolytic (GO:0000738)2.89624629
78negative regulation of DNA recombination (GO:0045910)2.89558257
79ER overload response (GO:0006983)2.89006030
80mechanosensory behavior (GO:0007638)2.88653104
81negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.88026438
82transmission of nerve impulse (GO:0019226)2.86848799
83protein localization to synapse (GO:0035418)2.86091816
84vocalization behavior (GO:0071625)2.85506942
85neuron-neuron synaptic transmission (GO:0007270)2.83755712
86detection of calcium ion (GO:0005513)2.82899267
87positive regulation of membrane potential (GO:0045838)2.82803418
88intraciliary transport (GO:0042073)2.82610743
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82286580
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81798677
91somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.81729218
92isotype switching (GO:0045190)2.81729218
93somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.81729218
94apical protein localization (GO:0045176)2.80827625
95respiratory chain complex IV assembly (GO:0008535)2.80569881
96synaptic transmission, glutamatergic (GO:0035249)2.80263518
97maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.79257857
98gamma-aminobutyric acid signaling pathway (GO:0007214)2.78851392
99DNA strand elongation involved in DNA replication (GO:0006271)2.78589047
100exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.78246116
101cyclic nucleotide catabolic process (GO:0009214)2.78018552
102negative regulation of protein localization to cell surface (GO:2000009)2.76939573
103attachment of spindle microtubules to kinetochore (GO:0008608)2.76934351
104locomotory exploration behavior (GO:0035641)2.76485919
105regulation of meiosis I (GO:0060631)2.76105862
106telomere maintenance via semi-conservative replication (GO:0032201)2.74690161
107membrane assembly (GO:0071709)2.74409142
108histone H2A acetylation (GO:0043968)2.74066464
109myelin maintenance (GO:0043217)2.73443333
110substantia nigra development (GO:0021762)2.72521317
111nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.72420850
112regulation of vesicle fusion (GO:0031338)2.71014270
113regulation of glutamate receptor signaling pathway (GO:1900449)2.70848119
114sister chromatid segregation (GO:0000819)2.70652559
115regulation of DNA endoreduplication (GO:0032875)2.69784759
116neurotransmitter uptake (GO:0001504)2.68894651
117DNA methylation involved in gamete generation (GO:0043046)2.68662655
118mitotic sister chromatid segregation (GO:0000070)2.68647793
119establishment of chromosome localization (GO:0051303)2.68276154
120positive regulation of action potential (GO:0045760)2.66902264
121negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.66815095
122negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.66815095
123negative regulation of mitotic sister chromatid segregation (GO:0033048)2.66815095
124negative regulation of mitotic sister chromatid separation (GO:2000816)2.66815095
125negative regulation of sister chromatid segregation (GO:0033046)2.66815095
126Golgi to plasma membrane protein transport (GO:0043001)2.66640954
127regulation of protein targeting to membrane (GO:0090313)2.66368198
128protein neddylation (GO:0045116)2.66222646
129recombinational repair (GO:0000725)2.64839428
130protein K6-linked ubiquitination (GO:0085020)2.64715246
131somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64610898
132somatic hypermutation of immunoglobulin genes (GO:0016446)2.64610898
133regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.64533459
134transferrin transport (GO:0033572)2.64211499
135peptidyl-tyrosine autophosphorylation (GO:0038083)2.63990298
136regulation of chromosome segregation (GO:0051983)2.63279853
137negative regulation of chromosome segregation (GO:0051985)2.62920000
138double-strand break repair via homologous recombination (GO:0000724)2.61878182
139regulation of mitotic metaphase/anaphase transition (GO:0030071)2.61253492
140regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.61253492
141negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60952078
142negative regulation of ligase activity (GO:0051352)2.60952078
143RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.60600994
144negative regulation of JUN kinase activity (GO:0043508)2.60526756
145negative regulation of synaptic transmission (GO:0050805)2.59843530
146spindle assembly checkpoint (GO:0071173)2.59351390
147signal peptide processing (GO:0006465)2.59147409
148RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.58968788
149tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.58968788
150mitotic spindle assembly checkpoint (GO:0007094)2.58501432
151DNA strand elongation (GO:0022616)2.58467583
152histone mRNA metabolic process (GO:0008334)2.58067421
153ribosome assembly (GO:0042255)2.57784612
154sister chromatid cohesion (GO:0007062)2.57341735
155protein localization to chromosome, centromeric region (GO:0071459)2.56786268
156protein polyglutamylation (GO:0018095)2.56784184
157IMP biosynthetic process (GO:0006188)2.56701039
158rRNA modification (GO:0000154)2.56127239
159L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55953209
160regulation of sister chromatid segregation (GO:0033045)2.55888732
161regulation of mitotic sister chromatid separation (GO:0010965)2.55888732
162regulation of mitotic sister chromatid segregation (GO:0033047)2.55888732
163regulation of centrosome cycle (GO:0046605)2.55535960
164protein targeting to Golgi (GO:0000042)2.55411791
165meiotic chromosome segregation (GO:0045132)2.54840958
166intra-S DNA damage checkpoint (GO:0031573)2.54676773
167auditory behavior (GO:0031223)2.54466485
168regulation of centrosome duplication (GO:0010824)2.53786074
169purine nucleobase biosynthetic process (GO:0009113)2.53646178
170adult walking behavior (GO:0007628)2.53558434
171protein-cofactor linkage (GO:0018065)2.53397226
172regulation of neuronal synaptic plasticity (GO:0048168)2.52471088
173DNA replication-dependent nucleosome organization (GO:0034723)2.52110416
174DNA replication-dependent nucleosome assembly (GO:0006335)2.52110416
175lactate metabolic process (GO:0006089)2.52032911
176protein localization to cilium (GO:0061512)2.51494220
177ionotropic glutamate receptor signaling pathway (GO:0035235)2.51089565
178regulation of neurotransmitter secretion (GO:0046928)2.51001938
179regulation of synaptic transmission, glutamatergic (GO:0051966)2.50585417
180response to X-ray (GO:0010165)2.50378601
181mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.49371947
182regulation of catecholamine metabolic process (GO:0042069)2.48774878
183regulation of dopamine metabolic process (GO:0042053)2.48774878
184protein complex biogenesis (GO:0070271)2.48537583
185regulation of axon regeneration (GO:0048679)2.47706605
186regulation of neuron projection regeneration (GO:0070570)2.47706605
187trivalent inorganic cation transport (GO:0072512)2.47056572
188ferric iron transport (GO:0015682)2.47056572
189asymmetric protein localization (GO:0008105)2.46678583
190calcium ion-dependent exocytosis (GO:0017156)2.46081162
191nerve growth factor signaling pathway (GO:0038180)2.45114159
192neurotransmitter secretion (GO:0007269)2.45038350
193positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.44853256
194regulation of neurotransmitter transport (GO:0051588)2.44560020
195chaperone-mediated protein transport (GO:0072321)2.44113627
196dendrite development (GO:0016358)2.43317655
197vesicle docking involved in exocytosis (GO:0006904)2.42071228
198regulation of synaptic transmission, GABAergic (GO:0032228)2.39999314
199magnesium ion transport (GO:0015693)2.39696691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.05297442
2GBX2_23144817_ChIP-Seq_PC3_Human4.02474281
3EZH2_22144423_ChIP-Seq_EOC_Human3.81904203
4E2F7_22180533_ChIP-Seq_HELA_Human3.76020761
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.28386256
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.15021683
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.09351898
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.91382460
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.83996963
10TAF15_26573619_Chip-Seq_HEK293_Human2.72866221
11ELK1_19687146_ChIP-ChIP_HELA_Human2.64100256
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54959579
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.53454169
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.52750355
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47279685
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34318707
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27247197
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.22462141
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.22083601
20SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.18322046
21ZNF274_21170338_ChIP-Seq_K562_Hela2.16585963
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14048340
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.13896967
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09050970
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.07478878
26OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.07280969
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.07232357
28FUS_26573619_Chip-Seq_HEK293_Human2.04735262
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03274473
30AR_21572438_ChIP-Seq_LNCaP_Human2.02831685
31P300_19829295_ChIP-Seq_ESCs_Human1.98041777
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97709875
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96899078
34SMAD4_21799915_ChIP-Seq_A2780_Human1.96495539
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.96230310
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92866355
37VDR_23849224_ChIP-Seq_CD4+_Human1.92433246
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.89129164
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.88454860
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86835645
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.84952141
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.84148847
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80104336
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79813009
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79345900
46REST_21632747_ChIP-Seq_MESCs_Mouse1.77602803
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76290032
48* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76168335
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.75704610
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75237233
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74799356
52MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73979891
53MYC_18555785_ChIP-Seq_MESCs_Mouse1.73876115
54IGF1R_20145208_ChIP-Seq_DFB_Human1.72516212
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72303806
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72141007
57EZH2_27304074_Chip-Seq_ESCs_Mouse1.71481207
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70385938
59ER_23166858_ChIP-Seq_MCF-7_Human1.69114787
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68325464
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68252041
62STAT3_23295773_ChIP-Seq_U87_Human1.63942171
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57213071
64FOXP3_21729870_ChIP-Seq_TREG_Human1.57135382
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.55981444
66SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55846882
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55661257
68EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55652260
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55652260
70VDR_22108803_ChIP-Seq_LS180_Human1.54795590
71REST_18959480_ChIP-ChIP_MESCs_Mouse1.50735007
72RARB_27405468_Chip-Seq_BRAIN_Mouse1.50356984
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.48544842
74RNF2_27304074_Chip-Seq_NSC_Mouse1.48028271
75AR_21909140_ChIP-Seq_LNCAP_Human1.47820227
76MYC_18940864_ChIP-ChIP_HL60_Human1.46098509
77* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46084040
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46052908
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44788050
80TCF4_23295773_ChIP-Seq_U87_Human1.43581761
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42810605
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42459542
83EED_16625203_ChIP-ChIP_MESCs_Mouse1.41031972
84RNF2_27304074_Chip-Seq_ESCs_Mouse1.40397942
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.39000360
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.38765249
87MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36201229
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.34840870
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34642923
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.33833144
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.33138782
92EZH2_27294783_Chip-Seq_ESCs_Mouse1.32243153
93SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32033583
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.30576725
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.30411148
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30338077
97AR_25329375_ChIP-Seq_VCAP_Human1.30141738
98DCP1A_22483619_ChIP-Seq_HELA_Human1.29869437
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29022273
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.27975678
101MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27835036
102PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25786214
103E2F1_21310950_ChIP-Seq_MCF-7_Human1.25529063
104* EWS_26573619_Chip-Seq_HEK293_Human1.25120743
105ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25004751
106E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23984991
107TTF2_22483619_ChIP-Seq_HELA_Human1.22823004
108LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22650547
109THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22049648
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21990923
111CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20545438
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18868343
113HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18730504
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18289160
115EZH2_27294783_Chip-Seq_NPCs_Mouse1.17856346
116* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17436513
117HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17315988
118CMYC_18555785_Chip-Seq_ESCs_Mouse1.15465914
119P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14893764
120FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14884661
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14053141
122JUN_21703547_ChIP-Seq_K562_Human1.13989295
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13804013
124RUNX2_22187159_ChIP-Seq_PCA_Human1.13635060
125NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13213584
126ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12599483
127GABP_19822575_ChIP-Seq_HepG2_Human1.12411262
128RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12402198
129DROSHA_22980978_ChIP-Seq_HELA_Human1.12218168
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12145450
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11963512
132E2F1_18555785_Chip-Seq_ESCs_Mouse1.11675123
133P53_22387025_ChIP-Seq_ESCs_Mouse1.11547804
134KDM2B_26808549_Chip-Seq_REH_Human1.11137923
135SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10368576
136PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09701972
137POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09310965
138NANOG_16153702_ChIP-ChIP_HESCs_Human1.08117763
139STAT3_18555785_Chip-Seq_ESCs_Mouse1.07728867
140MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07218648
141ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04819267
142ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03596257
143WT1_19549856_ChIP-ChIP_CCG9911_Human1.03545152
144MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03519594
145FLI1_21867929_ChIP-Seq_TH2_Mouse1.03316236
146SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02909419
147EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02725394
148IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02588931
149TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02420489
150VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01764441
151SOX2_16153702_ChIP-ChIP_HESCs_Human1.00929476
152SOX2_18555785_Chip-Seq_ESCs_Mouse1.00299630
153POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99901544
154TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99901544
155IRF1_19129219_ChIP-ChIP_H3396_Human0.99698260
156MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98556331
157ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98224609
158IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97825713
159CBP_20019798_ChIP-Seq_JUKART_Human0.97825713
160NFE2_27457419_Chip-Seq_LIVER_Mouse0.96896728
161HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96249639
162MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91622897
163HTT_18923047_ChIP-ChIP_STHdh_Human0.91466395
164PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90910745
165KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90664352

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.07335789
2MP0004270_analgesia3.64968907
3MP0004859_abnormal_synaptic_plasticity3.58665530
4MP0008058_abnormal_DNA_repair3.45120328
5MP0010094_abnormal_chromosome_stability2.99389428
6MP0009780_abnormal_chondrocyte_physiolo2.89125908
7MP0005646_abnormal_pituitary_gland2.88946294
8MP0008057_abnormal_DNA_replication2.79876995
9MP0003635_abnormal_synaptic_transmissio2.76863033
10MP0001529_abnormal_vocalization2.71396030
11MP0003183_abnormal_peptide_metabolism2.63150557
12MP0002272_abnormal_nervous_system2.51729106
13MP0002064_seizures2.49825392
14MP0002734_abnormal_mechanical_nocicepti2.48536685
15MP0009745_abnormal_behavioral_response2.47741978
16MP0003787_abnormal_imprinting2.35682155
17MP0008877_abnormal_DNA_methylation2.35395685
18MP0000920_abnormal_myelination2.34649156
19MP0001968_abnormal_touch/_nociception2.34627214
20MP0002572_abnormal_emotion/affect_behav2.34352116
21MP0001905_abnormal_dopamine_level2.33267768
22MP0006292_abnormal_olfactory_placode2.32563314
23MP0002102_abnormal_ear_morphology2.31660302
24MP0002063_abnormal_learning/memory/cond2.23244860
25MP0000013_abnormal_adipose_tissue2.18960788
26MP0001486_abnormal_startle_reflex2.14511219
27MP0003111_abnormal_nucleus_morphology2.12199292
28MP0009046_muscle_twitch2.11812568
29MP0004957_abnormal_blastocyst_morpholog2.09702865
30MP0002736_abnormal_nociception_after2.03665146
31MP0003693_abnormal_embryo_hatching2.01396738
32MP0005171_absent_coat_pigmentation1.98685095
33MP0000372_irregular_coat_pigmentation1.91499846
34MP0002938_white_spotting1.88056464
35MP0004043_abnormal_pH_regulation1.84513955
36MP0005645_abnormal_hypothalamus_physiol1.82456410
37MP0009697_abnormal_copulation1.80811363
38MP0003077_abnormal_cell_cycle1.75785889
39MP0002735_abnormal_chemical_nociception1.73660495
40MP0008932_abnormal_embryonic_tissue1.72187935
41MP0001970_abnormal_pain_threshold1.68118574
42MP0001440_abnormal_grooming_behavior1.64873929
43MP0003329_amyloid_beta_deposits1.64155106
44MP0003718_maternal_effect1.64108749
45MP0002067_abnormal_sensory_capabilities1.63437215
46MP0001984_abnormal_olfaction1.61862103
47MP0002733_abnormal_thermal_nociception1.58183234
48MP0001501_abnormal_sleep_pattern1.57037435
49MP0000778_abnormal_nervous_system1.56816197
50MP0004142_abnormal_muscle_tone1.56770380
51MP0005253_abnormal_eye_physiology1.55991966
52MP0004147_increased_porphyrin_level1.55481209
53MP0006276_abnormal_autonomic_nervous1.54257707
54MP0001293_anophthalmia1.54003451
55MP0005386_behavior/neurological_phenoty1.53147363
56MP0004924_abnormal_behavior1.53147363
57MP0003890_abnormal_embryonic-extraembry1.52744429
58MP0004885_abnormal_endolymph1.52622295
59MP0005423_abnormal_somatic_nervous1.51489795
60MP0005379_endocrine/exocrine_gland_phen1.48974782
61MP0004742_abnormal_vestibular_system1.48817271
62MP0008569_lethality_at_weaning1.47803361
63MP0001502_abnormal_circadian_rhythm1.46765403
64MP0008007_abnormal_cellular_replicative1.46664518
65MP0010386_abnormal_urinary_bladder1.46632287
66MP0003937_abnormal_limbs/digits/tail_de1.45185299
67MP0002822_catalepsy1.44590952
68MP0003690_abnormal_glial_cell1.43109353
69MP0003122_maternal_imprinting1.42653446
70MP0003786_premature_aging1.40802642
71MP0002837_dystrophic_cardiac_calcinosis1.35624295
72MP0001986_abnormal_taste_sensitivity1.33839637
73MP0001485_abnormal_pinna_reflex1.33397732
74MP0003634_abnormal_glial_cell1.32689889
75MP0000955_abnormal_spinal_cord1.30101636
76MP0005187_abnormal_penis_morphology1.29087569
77MP0008789_abnormal_olfactory_epithelium1.28359072
78MP0002229_neurodegeneration1.27208293
79MP0003631_nervous_system_phenotype1.25681503
80MP0002557_abnormal_social/conspecific_i1.25220449
81MP0003632_abnormal_nervous_system1.24590204
82MP0002234_abnormal_pharynx_morphology1.24391167
83MP0003633_abnormal_nervous_system1.20052467
84MP0002882_abnormal_neuron_morphology1.19744103
85MP0005367_renal/urinary_system_phenotyp1.19166826
86MP0000516_abnormal_urinary_system1.19166826
87MP0002066_abnormal_motor_capabilities/c1.19165331
88MP0001188_hyperpigmentation1.19109331
89MP0003950_abnormal_plasma_membrane1.18106410
90MP0002184_abnormal_innervation1.18015943
91MP0002638_abnormal_pupillary_reflex1.15761713
92MP0002160_abnormal_reproductive_system1.14347294
93MP0005248_abnormal_Harderian_gland1.10712988
94MP0001963_abnormal_hearing_physiology1.09680812
95MP0006035_abnormal_mitochondrial_morpho1.09128237
96MP0006054_spinal_hemorrhage1.07569924
97MP0000653_abnormal_sex_gland1.07465880
98MP0003119_abnormal_digestive_system1.05823669
99MP0000647_abnormal_sebaceous_gland1.05692127
100MP0004811_abnormal_neuron_physiology1.05591430
101MP0002233_abnormal_nose_morphology1.03916592
102MP0001145_abnormal_male_reproductive1.02989381
103MP0005084_abnormal_gallbladder_morpholo1.02522848
104MP0000631_abnormal_neuroendocrine_gland1.01558315
105MP0002909_abnormal_adrenal_gland0.99855454
106MP0001764_abnormal_homeostasis0.99447570
107MP0005551_abnormal_eye_electrophysiolog0.98561391
108MP0002751_abnormal_autonomic_nervous0.98133281
109MP0002084_abnormal_developmental_patter0.97282751
110MP0005394_taste/olfaction_phenotype0.95005190
111MP0005499_abnormal_olfactory_system0.95005190
112MP0002090_abnormal_vision0.93372046
113MP0003121_genomic_imprinting0.92776663
114MP0004036_abnormal_muscle_relaxation0.92390892
115MP0005391_vision/eye_phenotype0.91732645
116MP0003567_abnormal_fetal_cardiomyocyte0.91229138
117MP0004197_abnormal_fetal_growth/weight/0.90996182
118MP0000427_abnormal_hair_cycle0.90925009
119MP0004085_abnormal_heartbeat0.90182537
120MP0004145_abnormal_muscle_electrophysio0.89631437
121MP0010030_abnormal_orbit_morphology0.89327233
122MP0008995_early_reproductive_senescence0.89045094
123MP0006036_abnormal_mitochondrial_physio0.88672367
124MP0001697_abnormal_embryo_size0.88522503
125MP0003755_abnormal_palate_morphology0.88172392
126MP0006072_abnormal_retinal_apoptosis0.87759622
127MP0002163_abnormal_gland_morphology0.87304175
128MP0003186_abnormal_redox_activity0.87232352
129MP0005410_abnormal_fertilization0.86866449
130MP0005075_abnormal_melanosome_morpholog0.86034220
131MP0003879_abnormal_hair_cell0.85850797
132MP0004858_abnormal_nervous_system0.85326492
133MP0001286_abnormal_eye_development0.84058515
134MP0001664_abnormal_digestion0.83125451
135MP0000639_abnormal_adrenal_gland0.82058848
136MP0002085_abnormal_embryonic_tissue0.80836542
137MP0008260_abnormal_autophagy0.80456845
138MP0005389_reproductive_system_phenotype0.79718857
139MP0001672_abnormal_embryogenesis/_devel0.79207292
140MP0005380_embryogenesis_phenotype0.79207292
141MP0001177_atelectasis0.78720118
142MP0005409_darkened_coat_color0.78603136
143MP0003698_abnormal_male_reproductive0.78339616
144MP0001929_abnormal_gametogenesis0.78205281
145MP0000003_abnormal_adipose_tissue0.77658203
146MP0002152_abnormal_brain_morphology0.77295208
147MP0002282_abnormal_trachea_morphology0.76952915
148MP0001324_abnormal_eye_pigmentation0.76476006
149MP0005174_abnormal_tail_pigmentation0.75811850
150MP0001119_abnormal_female_reproductive0.74922010
151MP0002752_abnormal_somatic_nervous0.73833234
152MP0002876_abnormal_thyroid_physiology0.73578539
153MP0004215_abnormal_myocardial_fiber0.73436655
154MP0003136_yellow_coat_color0.72570798
155MP0009703_decreased_birth_body0.71174500
156MP0010234_abnormal_vibrissa_follicle0.69308297
157MP0005535_abnormal_body_temperature0.68837518
158MP0000358_abnormal_cell_content/0.67658461
159MP0000749_muscle_degeneration0.66658520
160MP0003195_calcinosis0.66516236
161MP0000230_abnormal_systemic_arterial0.62659817
162MP0001299_abnormal_eye_distance/0.62000916
163MP0000462_abnormal_digestive_system0.59056575
164MP0005310_abnormal_salivary_gland0.58622714
165MP0002210_abnormal_sex_determination0.58414044

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.24315667
2Atonic seizures (HP:0010819)4.00213500
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.99904659
4Degeneration of the lateral corticospinal tracts (HP:0002314)3.99904659
5Pheochromocytoma (HP:0002666)3.72854493
6Neuroendocrine neoplasm (HP:0100634)3.64429948
7Myokymia (HP:0002411)3.50457991
8Hyperventilation (HP:0002883)3.41749300
9Epileptic encephalopathy (HP:0200134)3.37214086
10Sensory axonal neuropathy (HP:0003390)3.34848662
11Abnormal hair whorl (HP:0010721)3.30286658
12Chromsome breakage (HP:0040012)3.22455476
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.21135327
14Neurofibrillary tangles (HP:0002185)3.20534041
15Abnormality of the corticospinal tract (HP:0002492)3.07103141
16Acute necrotizing encephalopathy (HP:0006965)2.95428451
17Peripheral hypomyelination (HP:0007182)2.94292723
18Volvulus (HP:0002580)2.92920629
19Retinal dysplasia (HP:0007973)2.91165089
20Abnormality of chromosome stability (HP:0003220)2.88321958
21Colon cancer (HP:0003003)2.85568704
22Abnormality of the labia minora (HP:0012880)2.84268170
23Medial flaring of the eyebrow (HP:0010747)2.75124999
24Gait imbalance (HP:0002141)2.73817099
25Progressive cerebellar ataxia (HP:0002073)2.73811576
26Meckel diverticulum (HP:0002245)2.72650056
27Focal seizures (HP:0007359)2.69948730
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.68727392
29Abnormal mitochondria in muscle tissue (HP:0008316)2.67419740
30Hypothermia (HP:0002045)2.63528757
31Progressive macrocephaly (HP:0004481)2.61872084
32Abnormality of the ileum (HP:0001549)2.58255514
33Poor speech (HP:0002465)2.57687464
34Congenital primary aphakia (HP:0007707)2.53115810
35Dysmetria (HP:0001310)2.50599079
36Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.50350127
37Genital tract atresia (HP:0001827)2.47656697
38Nephrogenic diabetes insipidus (HP:0009806)2.47206487
39Vaginal atresia (HP:0000148)2.46518095
40Anxiety (HP:0000739)2.45259958
41Spastic gait (HP:0002064)2.45089279
42Scanning speech (HP:0002168)2.44391474
43Febrile seizures (HP:0002373)2.43221693
44Visual hallucinations (HP:0002367)2.40612719
45Abnormal lung lobation (HP:0002101)2.40098825
46Broad-based gait (HP:0002136)2.38630682
47Increased hepatocellular lipid droplets (HP:0006565)2.36780564
48Ankle clonus (HP:0011448)2.36339122
49Hyperinsulinemic hypoglycemia (HP:0000825)2.35857634
50Gaze-evoked nystagmus (HP:0000640)2.34952953
51Increased CSF lactate (HP:0002490)2.34529203
52Pancreatic fibrosis (HP:0100732)2.34347651
53Cerebral hypomyelination (HP:0006808)2.29624670
54Dialeptic seizures (HP:0011146)2.29275372
55Abnormality of the preputium (HP:0100587)2.28159632
56Autoamputation (HP:0001218)2.26310086
57Thickened helices (HP:0000391)2.25197983
58Intestinal atresia (HP:0011100)2.25185277
59Epileptiform EEG discharges (HP:0011182)2.23246537
60Lipid accumulation in hepatocytes (HP:0006561)2.22831797
61Cortical dysplasia (HP:0002539)2.22769554
62Glioma (HP:0009733)2.22721500
63Limb dystonia (HP:0002451)2.21445575
64Abnormality of the periventricular white matter (HP:0002518)2.21098265
65Cerebral inclusion bodies (HP:0100314)2.20965688
66Abnormality of calcium-phosphate metabolism (HP:0100530)2.20811904
67Truncal ataxia (HP:0002078)2.19211915
68Neoplasm of the peripheral nervous system (HP:0100007)2.18645071
69Absence seizures (HP:0002121)2.18634990
70Supranuclear gaze palsy (HP:0000605)2.18425987
71Leukodystrophy (HP:0002415)2.18324684
72Pancreatic cysts (HP:0001737)2.16750711
73Failure to thrive in infancy (HP:0001531)2.15836134
74Menstrual irregularities (HP:0000858)2.15828831
75Generalized tonic-clonic seizures (HP:0002069)2.14901546
76Termporal pattern (HP:0011008)2.13918423
77Insidious onset (HP:0003587)2.13918423
78Nephronophthisis (HP:0000090)2.13442210
79Rhabdomyosarcoma (HP:0002859)2.13103361
80Acute encephalopathy (HP:0006846)2.13103116
81Polydipsia (HP:0001959)2.12608348
82Abnormal drinking behavior (HP:0030082)2.12608348
83Papillary thyroid carcinoma (HP:0002895)2.11114774
84Hyperglycinemia (HP:0002154)2.10657727
85Abnormality of the anterior horn cell (HP:0006802)2.10607737
86Degeneration of anterior horn cells (HP:0002398)2.10607737
87Neoplasm of the adrenal cortex (HP:0100641)2.10475408
88Ependymoma (HP:0002888)2.09738907
89True hermaphroditism (HP:0010459)2.07003175
90Blue irides (HP:0000635)2.06919417
91Neoplasm of the adrenal gland (HP:0100631)2.06715343
92Small intestinal stenosis (HP:0012848)2.05806721
93Duodenal stenosis (HP:0100867)2.05806721
94Abnormality of the duodenum (HP:0002246)2.05614158
95Increased serum pyruvate (HP:0003542)2.04726723
96Mitochondrial inheritance (HP:0001427)2.04646310
97EEG with generalized epileptiform discharges (HP:0011198)2.04515460
98Abnormality of midbrain morphology (HP:0002418)2.04482500
99Molar tooth sign on MRI (HP:0002419)2.04482500
100Action tremor (HP:0002345)2.04014010
101Slow saccadic eye movements (HP:0000514)2.03349024
102Megalencephaly (HP:0001355)2.02569090
103Barrel-shaped chest (HP:0001552)2.02264994
104Sloping forehead (HP:0000340)2.01924943
105Agitation (HP:0000713)1.98479165
106Hypsarrhythmia (HP:0002521)1.98417455
107Drooling (HP:0002307)1.98285363
108Excessive salivation (HP:0003781)1.98285363
109Akinesia (HP:0002304)1.95356963
110Hepatic necrosis (HP:0002605)1.95330278
111Abnormal eating behavior (HP:0100738)1.94502010
112Onion bulb formation (HP:0003383)1.94188912
113Pancreatic islet-cell hyperplasia (HP:0004510)1.93928145
114Increased circulating renin level (HP:0000848)1.93538963
115Hypoglycemic coma (HP:0001325)1.93119291
116Renal Fanconi syndrome (HP:0001994)1.91255908
117Poor coordination (HP:0002370)1.91152279
118Embryonal renal neoplasm (HP:0011794)1.91135394
119Hepatocellular necrosis (HP:0001404)1.90771860
120Aplasia/Hypoplasia of the tongue (HP:0010295)1.89656147
121Urinary bladder sphincter dysfunction (HP:0002839)1.88957498
122Dynein arm defect of respiratory motile cilia (HP:0012255)1.88751466
123Absent/shortened dynein arms (HP:0200106)1.88751466
124Abnormality of glycolysis (HP:0004366)1.88093605
125Progressive inability to walk (HP:0002505)1.87740948
126Astrocytoma (HP:0009592)1.87294848
127Abnormality of the astrocytes (HP:0100707)1.87294848
128Abnormality of methionine metabolism (HP:0010901)1.87019134
129Short tibia (HP:0005736)1.86882435
130Tubulointerstitial nephritis (HP:0001970)1.86799083
131Birth length less than 3rd percentile (HP:0003561)1.86745429
132Gonadotropin excess (HP:0000837)1.86385784
133Large for gestational age (HP:0001520)1.85955031
134Increased serum lactate (HP:0002151)1.85720265
135Dysdiadochokinesis (HP:0002075)1.84431190
136Nephroblastoma (Wilms tumor) (HP:0002667)1.83202962
137Adrenal hypoplasia (HP:0000835)1.82129911
138Median cleft lip (HP:0000161)1.82081034
139Lower limb muscle weakness (HP:0007340)1.81967258
140Bifid tongue (HP:0010297)1.80089654
141Aplasia/Hypoplasia of the tibia (HP:0005772)1.79486396
142Disproportionate short-trunk short stature (HP:0003521)1.79322796
143Absent speech (HP:0001344)1.79193588
144Triphalangeal thumb (HP:0001199)1.77908165
145Widely spaced teeth (HP:0000687)1.77739182
146Aplasia/Hypoplasia of the lens (HP:0008063)1.77455581
147Postaxial hand polydactyly (HP:0001162)1.76445463
148Stenosis of the external auditory canal (HP:0000402)1.76374597
149Oligodactyly (hands) (HP:0001180)1.76224597
150Abnormal auditory evoked potentials (HP:0006958)1.76082365
151Astigmatism (HP:0000483)1.75675004
152Methylmalonic acidemia (HP:0002912)1.75571069
153Postaxial foot polydactyly (HP:0001830)1.73322801
154Type II lissencephaly (HP:0007260)1.73205862
155Specific learning disability (HP:0001328)1.73140121
156Cerebral edema (HP:0002181)1.73078060
157Abnormality of the metopic suture (HP:0005556)1.72511817
158Hypoglycemic seizures (HP:0002173)1.72414608
159Hypokalemic alkalosis (HP:0001949)1.72290562
160Polyphagia (HP:0002591)1.72164531
161Generalized myoclonic seizures (HP:0002123)1.71274387
162Hyperglycinuria (HP:0003108)1.70869749
163Abnormality of serine family amino acid metabolism (HP:0010894)1.70615982
164Abnormality of glycine metabolism (HP:0010895)1.70615982
165Poor suck (HP:0002033)1.70256945
166Abnormality of the renal medulla (HP:0100957)1.67664941
167Ectopic kidney (HP:0000086)1.67602429
168Medulloblastoma (HP:0002885)1.66664410
169Supernumerary spleens (HP:0009799)1.65878276
170Preaxial hand polydactyly (HP:0001177)1.65652983
171Type I transferrin isoform profile (HP:0003642)1.64702489
172Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64670079
173Renal cortical cysts (HP:0000803)1.64377836
174Prominent metopic ridge (HP:0005487)1.63115069
175Hypoplastic pelvis (HP:0008839)1.62054205
176Clubbing of toes (HP:0100760)1.58192804
177Absent radius (HP:0003974)1.58153195
178Abnormality of the carotid arteries (HP:0005344)1.57383524
179Abnormality of serum amino acid levels (HP:0003112)1.57213818
180Methylmalonic aciduria (HP:0012120)1.57068779
181Long clavicles (HP:0000890)1.56816472

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.83091863
2TRIM283.57076453
3OXSR12.96775095
4STK392.94968877
5BUB12.78100191
6NTRK32.52445408
7CDK192.35430775
8PLK42.32750741
9ZAK2.32057101
10MAP2K72.31452002
11PLK32.29826296
12SRPK12.28767017
13TSSK62.25209569
14TTK2.14888927
15EIF2AK32.14860614
16PRKD32.12469579
17WEE12.08333867
18CDC72.08108464
19PRPF4B2.05264370
20MKNK22.03380073
21BCR2.02678763
22FRK2.02458958
23MAP3K42.00159261
24NEK11.98228144
25NUAK11.93479693
26PBK1.89374241
27MKNK11.86471668
28EIF2AK11.79170372
29AKT31.77991298
30STK161.73458615
31ARAF1.72063778
32NEK61.68513886
33ERBB31.67951067
34ACVR1B1.67795537
35SGK2231.60144877
36SGK4941.60144877
37MUSK1.59389776
38WNK41.57353144
39BRSK21.55636585
40PLK21.54840846
41MAP3K121.54732966
42MAP3K131.49537565
43BMPR21.43927916
44PLK11.41945682
45BRAF1.41931410
46MAP3K91.40728950
47TNIK1.39978013
48MAPKAPK51.39154117
49MAPK131.37621362
50CCNB11.37605961
51STK38L1.36588118
52NTRK11.36231208
53KSR21.34772032
54PAK61.33217315
55CAMK2B1.32575732
56CDK81.30927431
57PDK41.30863412
58PDK31.30863412
59VRK21.24818939
60EPHA41.23962417
61TAOK31.21658752
62UHMK11.21131940
63VRK11.20049666
64STK241.19923614
65MAP4K21.19537378
66LIMK11.18284476
67CAMK2A1.15422342
68TGFBR11.14206864
69CSNK1G31.12886642
70PKN11.11191448
71MARK11.05190090
72BMPR1B1.04706871
73MINK11.02590105
74CSNK1A1L1.00727867
75CSNK1G20.99727280
76PINK10.99599824
77CDK50.98754906
78WNK10.97755653
79NLK0.96859319
80BRSK10.96157271
81CAMK2D0.94969123
82STK30.94756008
83WNK30.94321457
84INSRR0.92932426
85CSNK1G10.90852785
86PRKCH0.90740064
87NTRK20.90026798
88SGK20.88591327
89MAP3K20.88275390
90DAPK20.87289403
91EIF2AK20.86155240
92ATR0.85583598
93MAP3K60.84221602
94PRKCE0.83787955
95TAF10.82824807
96BRD40.81993138
97GRK10.80270903
98PAK30.79410423
99EPHB10.79066725
100ERBB40.78256794
101PDK20.77373033
102MAP2K40.75149535
103RAF10.75048179
104PNCK0.73064927
105MAPK150.72335101
106BCKDK0.72276511
107TIE10.71673364
108YES10.70670816
109ATM0.70487081
110CAMK2G0.70021907
111DYRK20.69500090
112CAMKK20.69365011
113GRK50.68438050
114CHEK20.68207118
115AURKB0.67344095
116KSR10.64487103
117CDK140.64461302
118MET0.63600420
119ROCK20.62853068
120PASK0.62233307
121CDK180.60155626
122DYRK30.59862998
123PRKCQ0.58524541
124CDK30.58048258
125PRKD20.57687107
126PHKG20.57432799
127PHKG10.57432799
128CDK150.55406377
129MARK20.53275409
130FGFR20.53097945
131DAPK10.51929345
132NEK20.51511698
133LATS10.50471336
134SGK10.50064685
135PTK2B0.48703047
136MST40.48342180
137PRKCG0.48055982
138ITK0.48029576
139CHEK10.46844539
140FGFR10.45450166
141HIPK20.44995977
142RPS6KA40.43683194
143CDK11A0.43214685
144CDK90.42721094
145CLK10.42518776
146CSNK1A10.40108923
147SIK30.39711406
148FER0.39579704
149CDC42BPA0.39456272
150GRK70.39132133
151PRKACA0.38982481
152RET0.38635865
153TYRO30.38472771
154FES0.37664203
155OBSCN0.37430087
156CSNK1E0.34135501
157RPS6KB20.33981570
158CSNK2A20.33979305
159CSNK2A10.33294080
160CDK10.32500178
161PRKDC0.31579409
162CSNK1D0.30430221

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.37870381
2Mismatch repair_Homo sapiens_hsa034303.07798457
3Non-homologous end-joining_Homo sapiens_hsa034503.02832688
4Homologous recombination_Homo sapiens_hsa034402.58805988
5Synaptic vesicle cycle_Homo sapiens_hsa047212.57754002
6Fanconi anemia pathway_Homo sapiens_hsa034602.52974912
7Protein export_Homo sapiens_hsa030602.50341843
8DNA replication_Homo sapiens_hsa030302.39697795
9Collecting duct acid secretion_Homo sapiens_hsa049662.34309759
10Nicotine addiction_Homo sapiens_hsa050332.31543213
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.22343953
12Propanoate metabolism_Homo sapiens_hsa006402.06262413
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.05276895
14GABAergic synapse_Homo sapiens_hsa047272.04252551
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03991086
16Morphine addiction_Homo sapiens_hsa050322.02811019
17Vibrio cholerae infection_Homo sapiens_hsa051102.00034145
18Nucleotide excision repair_Homo sapiens_hsa034201.99851119
19RNA polymerase_Homo sapiens_hsa030201.99150435
20Serotonergic synapse_Homo sapiens_hsa047261.96476189
21Circadian entrainment_Homo sapiens_hsa047131.95155620
22RNA transport_Homo sapiens_hsa030131.93474977
23Glutamatergic synapse_Homo sapiens_hsa047241.92075994
24Amphetamine addiction_Homo sapiens_hsa050311.89224510
25RNA degradation_Homo sapiens_hsa030181.88499551
26Insulin secretion_Homo sapiens_hsa049111.86880312
27Olfactory transduction_Homo sapiens_hsa047401.86791470
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.82299677
29Ether lipid metabolism_Homo sapiens_hsa005651.82279114
30Oxidative phosphorylation_Homo sapiens_hsa001901.80515727
31Long-term potentiation_Homo sapiens_hsa047201.80443023
32Dopaminergic synapse_Homo sapiens_hsa047281.80081794
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.79137565
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73661797
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73111992
36Cocaine addiction_Homo sapiens_hsa050301.72631449
37Cell cycle_Homo sapiens_hsa041101.72004779
38Long-term depression_Homo sapiens_hsa047301.70114812
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.70037257
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.65195180
41Fatty acid elongation_Homo sapiens_hsa000621.63518619
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60795121
43Base excision repair_Homo sapiens_hsa034101.55409976
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.47559406
45Spliceosome_Homo sapiens_hsa030401.44734497
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43550256
47Taste transduction_Homo sapiens_hsa047421.40890066
48Cholinergic synapse_Homo sapiens_hsa047251.38616639
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38559442
50Butanoate metabolism_Homo sapiens_hsa006501.33936531
51Sphingolipid metabolism_Homo sapiens_hsa006001.33414708
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.31686764
53One carbon pool by folate_Homo sapiens_hsa006701.30813899
54Parkinsons disease_Homo sapiens_hsa050121.28248129
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27262397
56Alzheimers disease_Homo sapiens_hsa050101.26301509
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24428933
58Selenocompound metabolism_Homo sapiens_hsa004501.23140671
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21971237
60Pyruvate metabolism_Homo sapiens_hsa006201.21267138
61mRNA surveillance pathway_Homo sapiens_hsa030151.18963430
62Circadian rhythm_Homo sapiens_hsa047101.18786085
63Gastric acid secretion_Homo sapiens_hsa049711.18545825
64Dorso-ventral axis formation_Homo sapiens_hsa043201.17046344
65Salivary secretion_Homo sapiens_hsa049701.16985341
66Renin secretion_Homo sapiens_hsa049241.16482003
67Ovarian steroidogenesis_Homo sapiens_hsa049131.16457386
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15983924
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15758358
70Rheumatoid arthritis_Homo sapiens_hsa053231.14140821
71Steroid biosynthesis_Homo sapiens_hsa001001.13796351
72Vascular smooth muscle contraction_Homo sapiens_hsa042701.12680715
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11362936
74Axon guidance_Homo sapiens_hsa043601.08894775
75Pyrimidine metabolism_Homo sapiens_hsa002401.06039449
76Oxytocin signaling pathway_Homo sapiens_hsa049211.05414145
77Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03641557
78Purine metabolism_Homo sapiens_hsa002301.02824870
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02282327
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01181035
81cAMP signaling pathway_Homo sapiens_hsa040240.99640342
82Folate biosynthesis_Homo sapiens_hsa007900.98528492
83Sulfur metabolism_Homo sapiens_hsa009200.97349370
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92910846
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92351492
86Regulation of autophagy_Homo sapiens_hsa041400.92321741
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92157844
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.91612851
89Calcium signaling pathway_Homo sapiens_hsa040200.91012107
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90093948
91Fatty acid metabolism_Homo sapiens_hsa012120.89435771
92Ras signaling pathway_Homo sapiens_hsa040140.87562754
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87029614
94Type I diabetes mellitus_Homo sapiens_hsa049400.86073366
95Vitamin B6 metabolism_Homo sapiens_hsa007500.84172519
96Oocyte meiosis_Homo sapiens_hsa041140.83903130
97Renal cell carcinoma_Homo sapiens_hsa052110.82578065
98Huntingtons disease_Homo sapiens_hsa050160.81920418
99Cardiac muscle contraction_Homo sapiens_hsa042600.80697548
100Peroxisome_Homo sapiens_hsa041460.80682497
101Pancreatic secretion_Homo sapiens_hsa049720.80399170
102beta-Alanine metabolism_Homo sapiens_hsa004100.78203585
103GnRH signaling pathway_Homo sapiens_hsa049120.77501703
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77007969
105Gap junction_Homo sapiens_hsa045400.76391105
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75616187
107p53 signaling pathway_Homo sapiens_hsa041150.74395019
108Linoleic acid metabolism_Homo sapiens_hsa005910.74271817
109Glutathione metabolism_Homo sapiens_hsa004800.72874866
110ErbB signaling pathway_Homo sapiens_hsa040120.70060625
111Carbon metabolism_Homo sapiens_hsa012000.68342044
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68016217
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65923360
114Phagosome_Homo sapiens_hsa041450.65681731
115Metabolic pathways_Homo sapiens_hsa011000.64689314
116MAPK signaling pathway_Homo sapiens_hsa040100.64544403
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64287824
118Fatty acid degradation_Homo sapiens_hsa000710.63000727
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62169552
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61219736
121Choline metabolism in cancer_Homo sapiens_hsa052310.60378144
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59357992
123Type II diabetes mellitus_Homo sapiens_hsa049300.59247698
124Hippo signaling pathway_Homo sapiens_hsa043900.59133365
125Phototransduction_Homo sapiens_hsa047440.58888475
126Biosynthesis of amino acids_Homo sapiens_hsa012300.57977827
127Estrogen signaling pathway_Homo sapiens_hsa049150.57558574
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.56482938
129Hedgehog signaling pathway_Homo sapiens_hsa043400.55807710
130* Basal transcription factors_Homo sapiens_hsa030220.55370237
131Lysosome_Homo sapiens_hsa041420.53258239
132Endocytosis_Homo sapiens_hsa041440.52878537
133Nitrogen metabolism_Homo sapiens_hsa009100.52596644
134Tryptophan metabolism_Homo sapiens_hsa003800.49895579
135Melanogenesis_Homo sapiens_hsa049160.49142110
136TGF-beta signaling pathway_Homo sapiens_hsa043500.48762958
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46124383
138Wnt signaling pathway_Homo sapiens_hsa043100.46091001
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44110485
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43879008
141Thyroid hormone synthesis_Homo sapiens_hsa049180.43469251
142Basal cell carcinoma_Homo sapiens_hsa052170.43415159
143Inositol phosphate metabolism_Homo sapiens_hsa005620.42894909
144Dilated cardiomyopathy_Homo sapiens_hsa054140.42078533
145Glioma_Homo sapiens_hsa052140.40290454
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39275582
147Ribosome_Homo sapiens_hsa030100.37716700
148Alcoholism_Homo sapiens_hsa050340.37565181
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35505394
150Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34678708
151T cell receptor signaling pathway_Homo sapiens_hsa046600.34593115
152Arginine and proline metabolism_Homo sapiens_hsa003300.34591353
153Chemokine signaling pathway_Homo sapiens_hsa040620.32908718
154Autoimmune thyroid disease_Homo sapiens_hsa053200.32326850
155Lysine degradation_Homo sapiens_hsa003100.31986855
156N-Glycan biosynthesis_Homo sapiens_hsa005100.30775404
157Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29427688
158Primary bile acid biosynthesis_Homo sapiens_hsa001200.24403174
159Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21721392
160Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21420349

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