TAF7L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is similar to a mouse gene that encodes a TATA box binding protein-associated factor, and shows testis-specific expression. The encoded protein could be a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)8.93298582
2positive regulation of meiosis (GO:0045836)7.73579299
3chromosome organization involved in meiosis (GO:0070192)7.60647495
4positive regulation of male gonad development (GO:2000020)7.34036934
5meiotic nuclear division (GO:0007126)7.28105309
6positive regulation of meiotic cell cycle (GO:0051446)7.21658632
7oocyte development (GO:0048599)6.58039726
8male meiosis I (GO:0007141)6.43561856
9regulation of male gonad development (GO:2000018)6.32453554
10oogenesis (GO:0048477)6.18136494
11gene silencing by RNA (GO:0031047)6.11967611
12acrosome reaction (GO:0007340)5.90961008
13negative regulation of meiosis (GO:0045835)5.79283192
14DNA alkylation (GO:0006305)5.74948456
15DNA methylation (GO:0006306)5.74948456
16nuclear pore complex assembly (GO:0051292)5.56092167
17nuclear pore organization (GO:0006999)5.42771683
18meiotic chromosome segregation (GO:0045132)5.34661194
19heterochromatin organization (GO:0070828)5.34119216
20protein neddylation (GO:0045116)5.34012203
21meiosis I (GO:0007127)5.30663176
22sex differentiation (GO:0007548)5.26575431
23regulation of DNA endoreduplication (GO:0032875)5.25679111
24platelet dense granule organization (GO:0060155)5.15062054
25DNA double-strand break processing (GO:0000729)5.12884678
26meiotic cell cycle process (GO:1903046)5.10367032
27histone H4-K12 acetylation (GO:0043983)5.02509058
28proteasome assembly (GO:0043248)5.01716464
29male sex determination (GO:0030238)4.98742440
30reciprocal DNA recombination (GO:0035825)4.96163248
31reciprocal meiotic recombination (GO:0007131)4.96163248
32sex determination (GO:0007530)4.71571754
33gene silencing (GO:0016458)4.68985071
34female gamete generation (GO:0007292)4.62777512
35negative regulation of synaptic transmission, GABAergic (GO:0032229)4.61538072
36sister chromatid cohesion (GO:0007062)4.55754721
37germ cell migration (GO:0008354)4.46458096
38DNA methylation or demethylation (GO:0044728)4.35812732
39tRNA methylation (GO:0030488)4.35325447
40microtubule depolymerization (GO:0007019)4.34891750
41DNA deamination (GO:0045006)4.27130782
42germ cell development (GO:0007281)4.23252419
43regulation of meiosis (GO:0040020)4.20883848
44ether lipid metabolic process (GO:0046485)4.14859214
45mitotic chromosome condensation (GO:0007076)4.11552244
46positive regulation of translational initiation (GO:0045948)4.09425639
47detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.08981730
48attachment of spindle microtubules to kinetochore (GO:0008608)4.05189397
49positive regulation of protein homodimerization activity (GO:0090073)4.04978667
50pore complex assembly (GO:0046931)4.01485892
51chaperone-mediated protein transport (GO:0072321)4.01270507
52synapsis (GO:0007129)3.98276065
53behavioral response to nicotine (GO:0035095)3.96955219
54resolution of meiotic recombination intermediates (GO:0000712)3.90672779
55negative regulation of protein localization to cell surface (GO:2000009)3.86731823
56histone H4-K8 acetylation (GO:0043982)3.80990389
57histone H4-K5 acetylation (GO:0043981)3.80990389
58regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.80540572
59DNA replication-dependent nucleosome organization (GO:0034723)3.78230672
60DNA replication-dependent nucleosome assembly (GO:0006335)3.78230672
61pre-miRNA processing (GO:0031054)3.74901570
62negative regulation of meiotic cell cycle (GO:0051447)3.72320986
63DNA synthesis involved in DNA repair (GO:0000731)3.71823894
64RNA methylation (GO:0001510)3.66824926
65regulation of gene silencing by RNA (GO:0060966)3.66737426
66regulation of posttranscriptional gene silencing (GO:0060147)3.66737426
67regulation of gene silencing by miRNA (GO:0060964)3.66737426
68oocyte maturation (GO:0001556)3.66195072
69fusion of sperm to egg plasma membrane (GO:0007342)3.59667797
70protein K6-linked ubiquitination (GO:0085020)3.57943055
71regulation of meiotic cell cycle (GO:0051445)3.53783592
72histone H3-K9 methylation (GO:0051567)3.53334286
73GMP metabolic process (GO:0046037)3.50830895
74protein-cofactor linkage (GO:0018065)3.50703748
75rRNA methylation (GO:0031167)3.49948690
76Sertoli cell development (GO:0060009)3.49544617
77regulation of protein polyubiquitination (GO:1902914)3.48551626
78dentate gyrus development (GO:0021542)3.47650703
79negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.46514503
80regulation of histone H3-K9 methylation (GO:0051570)3.46026034
81DNA modification (GO:0006304)3.45788939
82pseudouridine synthesis (GO:0001522)3.44992109
83regulation of timing of cell differentiation (GO:0048505)3.43532103
84negative regulation of DNA-dependent DNA replication (GO:2000104)3.39582196
85peptidyl-lysine dimethylation (GO:0018027)3.36300929
86kinetochore organization (GO:0051383)3.36271308
87mitochondrial respiratory chain complex I assembly (GO:0032981)3.29448136
88NADH dehydrogenase complex assembly (GO:0010257)3.29448136
89mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.29448136
90meiotic cell cycle (GO:0051321)3.29338699
91mitotic sister chromatid cohesion (GO:0007064)3.29165400
92regulation of retinoic acid receptor signaling pathway (GO:0048385)3.26146219
93rRNA modification (GO:0000154)3.26044814
94response to nitrosative stress (GO:0051409)3.25554340
95chromatin assembly (GO:0031497)3.24412038
96cellular process involved in reproduction in multicellular organism (GO:0022412)3.23855965
97snRNA processing (GO:0016180)3.23362545
98protein complex biogenesis (GO:0070271)3.23118514
99microtubule severing (GO:0051013)3.22874547
100kinetochore assembly (GO:0051382)3.22259459
101forebrain neuron development (GO:0021884)3.19938651
102snRNA metabolic process (GO:0016073)3.17790507
103negative regulation of DNA repair (GO:0045738)3.16149683
104DNA topological change (GO:0006265)3.15483652
105DNA packaging (GO:0006323)3.15324453
106* spermatogenesis (GO:0007283)3.15251233
107* male gamete generation (GO:0048232)3.15238851
108spermatid development (GO:0007286)3.14979881
109S-adenosylmethionine metabolic process (GO:0046500)3.13811036
110replication fork processing (GO:0031297)3.13268248
111regulation of development, heterochronic (GO:0040034)3.12547133
112regulation of RNA export from nucleus (GO:0046831)3.11618834
113regulation of sarcomere organization (GO:0060297)3.11379895
114inner cell mass cell proliferation (GO:0001833)3.10171448
115DNA replication checkpoint (GO:0000076)3.05895048
116nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.00442609
117long term synaptic depression (GO:0060292)3.00116313
118histone H3-K9 modification (GO:0061647)2.99782460
119microtubule polymerization or depolymerization (GO:0031109)2.99489650
120regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.98995218
121inositol phosphate dephosphorylation (GO:0046855)2.98772002
122phosphorylated carbohydrate dephosphorylation (GO:0046838)2.98772002
123regulation of T cell chemotaxis (GO:0010819)2.97267898
124positive regulation of T cell chemotaxis (GO:0010820)2.97267898
125mitochondrial respiratory chain complex assembly (GO:0033108)2.96594558
126histone H2A acetylation (GO:0043968)2.96499600
127negative regulation of mast cell activation (GO:0033004)2.96111485
128mitotic spindle assembly checkpoint (GO:0007094)2.95915100
129adaptation of signaling pathway (GO:0023058)2.95825828
130histone H4-K16 acetylation (GO:0043984)2.94759955
131* gamete generation (GO:0007276)2.94015793
132response to pheromone (GO:0019236)2.93864364
133macroautophagy (GO:0016236)2.93839701
134regulation of glutamate secretion (GO:0014048)2.92879681
135microtubule anchoring (GO:0034453)2.92602136
136guanosine-containing compound biosynthetic process (GO:1901070)2.92446177
137chromosome organization (GO:0051276)2.92101763
138negative regulation of chromosome segregation (GO:0051985)2.91518814
139spindle assembly checkpoint (GO:0071173)2.91304966
140monoubiquitinated protein deubiquitination (GO:0035520)2.89478831
141regulation of centriole replication (GO:0046599)2.88547986
142inositol phosphate catabolic process (GO:0071545)2.85141737
143L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.84556878
144negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.83987700
145negative regulation of sister chromatid segregation (GO:0033046)2.83987700
146negative regulation of mitotic sister chromatid separation (GO:2000816)2.83987700
147negative regulation of mitotic sister chromatid segregation (GO:0033048)2.83987700
148negative regulation of nuclear division (GO:0051784)2.83114223
149chromosome condensation (GO:0030261)2.82822307
150GTP biosynthetic process (GO:0006183)2.82659040
151chromatin silencing (GO:0006342)2.82540606
152mitotic nuclear envelope disassembly (GO:0007077)2.81664856
153reflex (GO:0060004)2.79837677
154mitotic spindle checkpoint (GO:0071174)2.79389050
155plasma membrane fusion (GO:0045026)2.77433007
156peptidyl-histidine modification (GO:0018202)2.73439032
157IMP biosynthetic process (GO:0006188)2.72560422
158maturation of 5.8S rRNA (GO:0000460)2.71407962
159DNA integration (GO:0015074)2.71217854
160tRNA processing (GO:0008033)2.66688677
161postreplication repair (GO:0006301)2.65145241
162positive regulation of histone H3-K4 methylation (GO:0051571)2.60109365
163transcription from mitochondrial promoter (GO:0006390)2.58376369
164calcium ion-dependent exocytosis (GO:0017156)2.58134954
165purine nucleotide salvage (GO:0032261)2.57892282
166detection of mechanical stimulus involved in sensory perception (GO:0050974)2.56163695
167ribosome assembly (GO:0042255)2.56154130
168axoneme assembly (GO:0035082)2.55677543
169nucleobase biosynthetic process (GO:0046112)2.54998522
170L-serine transport (GO:0015825)2.54427176
171preassembly of GPI anchor in ER membrane (GO:0016254)2.50420246
172regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.50263497
173UTP metabolic process (GO:0046051)2.49663161
174pyrimidine dimer repair (GO:0006290)2.49418575
175tRNA modification (GO:0006400)2.48931870
176single strand break repair (GO:0000012)2.48287499
177retinal ganglion cell axon guidance (GO:0031290)2.47465745
178thrombin receptor signaling pathway (GO:0070493)2.47463494
179negative regulation of amino acid transport (GO:0051956)2.47392991
180peroxisome fission (GO:0016559)2.46298700
181detection of mechanical stimulus (GO:0050982)2.46217843
182UTP biosynthetic process (GO:0006228)2.43735974
183amino acid salvage (GO:0043102)2.43628135
184L-methionine salvage (GO:0071267)2.43628135
185L-methionine biosynthetic process (GO:0071265)2.43628135
186exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.43417787
187dopamine transport (GO:0015872)2.43197474
188DNA catabolic process, exonucleolytic (GO:0000738)2.40915091
189sphingoid metabolic process (GO:0046519)2.38466427
190mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.37963811
191piRNA metabolic process (GO:0034587)14.3106344
192regulation of meiosis I (GO:0060631)12.4387610
193DNA methylation involved in gamete generation (GO:0043046)11.3032139
194synaptonemal complex assembly (GO:0007130)11.0253970
195synaptonemal complex organization (GO:0070193)10.1656448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.69895318
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.17717063
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.95024805
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.09648935
5VDR_22108803_ChIP-Seq_LS180_Human4.04177322
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.02335596
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.02335596
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.02335596
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.52042394
10ZNF274_21170338_ChIP-Seq_K562_Hela3.46526017
11HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse3.16403732
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09365255
13GABP_17652178_ChIP-ChIP_JURKAT_Human3.07774062
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.04334317
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.00231695
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.91316771
17AR_21909140_ChIP-Seq_LNCAP_Human2.81188418
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60123078
19EWS_26573619_Chip-Seq_HEK293_Human2.58581279
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.57719221
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.55977933
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.55756194
23IGF1R_20145208_ChIP-Seq_DFB_Human2.51103611
24CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.50341831
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.44707779
26MYC_18555785_ChIP-Seq_MESCs_Mouse2.43311157
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31274849
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28449355
29MYCN_18555785_ChIP-Seq_MESCs_Mouse2.24787798
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24178652
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22727903
32TAF15_26573619_Chip-Seq_HEK293_Human2.20983001
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18727880
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.14922500
35RNF2_27304074_Chip-Seq_NSC_Mouse2.09096479
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06243296
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04239410
38EZH2_22144423_ChIP-Seq_EOC_Human2.04041545
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01051934
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98535205
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.96409058
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.91941573
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.88018714
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87379883
45FUS_26573619_Chip-Seq_HEK293_Human1.85202185
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.76967100
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70685309
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69807560
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.69797840
50RUNX1_26923725_Chip-Seq_HPCs_Mouse1.69009509
51P300_19829295_ChIP-Seq_ESCs_Human1.68361980
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.68174830
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66750055
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65264518
55TP53_22573176_ChIP-Seq_HFKS_Human1.60267763
56GATA1_26923725_Chip-Seq_HPCs_Mouse1.57301642
57ELK1_19687146_ChIP-ChIP_HELA_Human1.56591484
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55364587
59GBX2_23144817_ChIP-Seq_PC3_Human1.54192654
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53798882
61ER_23166858_ChIP-Seq_MCF-7_Human1.53607487
62KDM5A_27292631_Chip-Seq_BREAST_Human1.53313632
63CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50732476
64LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48809682
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45717965
66FOXP3_21729870_ChIP-Seq_TREG_Human1.45339194
67* SOX2_19829295_ChIP-Seq_ESCs_Human1.43566226
68* NANOG_19829295_ChIP-Seq_ESCs_Human1.43566226
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43239568
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42705808
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41294201
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41085967
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40930787
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39267668
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37257225
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37054934
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36117682
78CBP_20019798_ChIP-Seq_JUKART_Human1.35016481
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35016481
80AR_25329375_ChIP-Seq_VCAP_Human1.34263641
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32358881
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.32159358
83CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31217301
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30590761
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30344979
86XRN2_22483619_ChIP-Seq_HELA_Human1.28948894
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28757025
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28157274
89RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27141027
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26284901
91EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25852170
92STAT3_23295773_ChIP-Seq_U87_Human1.25757681
93* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.24785891
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.21511721
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21317292
96TCF4_22108803_ChIP-Seq_LS180_Human1.20869587
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18378556
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18331987
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17875857
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17336412
101AR_20517297_ChIP-Seq_VCAP_Human1.17251316
102TCF4_23295773_ChIP-Seq_U87_Human1.16091176
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15166608
104SMAD4_21799915_ChIP-Seq_A2780_Human1.14335294
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14017489
106DCP1A_22483619_ChIP-Seq_HELA_Human1.12792453
107SALL4_22934838_ChIP-ChIP_CD34+_Human1.11089204
108CDX2_22108803_ChIP-Seq_LS180_Human1.09819065
109SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09791753
110REST_19997604_ChIP-ChIP_NEURONS_Mouse1.09620873
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09358361
112* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08685698
113IRF1_19129219_ChIP-ChIP_H3396_Human1.07813140
114MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07224378
115TP53_18474530_ChIP-ChIP_U2OS_Human1.06260479
116E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05753274
117BCAT_22108803_ChIP-Seq_LS180_Human1.05734427
118DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05721362
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04520850
120FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03901044
121FOXA1_25329375_ChIP-Seq_VCAP_Human1.03901044
122EZH2_27294783_Chip-Seq_NPCs_Mouse1.02672363
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01898241
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01518592
125CIITA_25753668_ChIP-Seq_RAJI_Human1.00447805
126SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00276824
127OCT4_19829295_ChIP-Seq_ESCs_Human0.99770901
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.99219062
129MYC_18940864_ChIP-ChIP_HL60_Human0.99096981
130PRDM14_20953172_ChIP-Seq_ESCs_Human0.98882335
131CHD1_26751641_Chip-Seq_LNCaP_Human0.98761377
132* HTT_18923047_ChIP-ChIP_STHdh_Human0.98725424
133FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98660098
134HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98641718
135GABP_19822575_ChIP-Seq_HepG2_Human0.97853812
136TAL1_26923725_Chip-Seq_HPCs_Mouse0.97235981
137NANOG_18555785_Chip-Seq_ESCs_Mouse0.95904709
138ELK4_26923725_Chip-Seq_MESODERM_Mouse0.94286394
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94200958
140* NANOG_20526341_ChIP-Seq_ESCs_Human0.93979293
141CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.93026186
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.92020710
143NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91235637
144TTF2_22483619_ChIP-Seq_HELA_Human0.89876056
145HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89873264
146BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89790384
147EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.89388916
148ZNF263_19887448_ChIP-Seq_K562_Human0.89016184
149TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88832664
150TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88169504
151* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87945629
152PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86904620
153PKCTHETA_26484144_Chip-Seq_BREAST_Human0.86820503
154TCF7_22412390_ChIP-Seq_EML_Mouse0.86524116
155SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86302784
156FLI1_21867929_ChIP-Seq_TH2_Mouse0.86086166
157FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85332858
158THAP11_20581084_ChIP-Seq_MESCs_Mouse0.84785354
159ETS1_22383799_ChIP-Seq_G1ME_Mouse0.83657228
160HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.83434883
161MYC_18358816_ChIP-ChIP_MESCs_Mouse0.82079508
162TFEB_21752829_ChIP-Seq_HELA_Human0.81559023
163TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.79947065
164FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.79841526
165E2F1_17053090_ChIP-ChIP_MCF-7_Human0.78181057
166ZFP281_18757296_ChIP-ChIP_E14_Mouse0.77370999
167DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.76700051
168SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.75972361
169GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.75174050
170GATA3_21867929_ChIP-Seq_TH1_Mouse0.74664859
171EST1_17652178_ChIP-ChIP_JURKAT_Human0.74518457
172TCF4_18268006_ChIP-ChIP_LS174T_Human0.73609846
173CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.73577395
174TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.73491373
175EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.72700968
176FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.72581129
177* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.72068773
178TET1_21490601_ChIP-Seq_MESCs_Mouse0.70147986
179DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.69794369
180VDR_23849224_ChIP-Seq_CD4+_Human0.69082053
181RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.69012748
182ETS1_20019798_ChIP-Seq_JURKAT_Human0.68663234
183NANOG_21062744_ChIP-ChIP_HESCs_Human0.68625844
184TP63_19390658_ChIP-ChIP_HaCaT_Human0.68534438
185ZFP281_27345836_Chip-Seq_ESCs_Mouse0.65747519
186ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.65035189

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence6.21552931
2MP0003718_maternal_effect4.26408410
3* MP0002210_abnormal_sex_determination4.02948361
4MP0003786_premature_aging3.68127535
5MP0002736_abnormal_nociception_after3.65816478
6MP0010386_abnormal_urinary_bladder3.61324381
7MP0003123_paternal_imprinting3.59783367
8* MP0001929_abnormal_gametogenesis3.58663640
9* MP0001145_abnormal_male_reproductive3.31207213
10MP0003950_abnormal_plasma_membrane3.07765815
11MP0001968_abnormal_touch/_nociception3.02431750
12* MP0000653_abnormal_sex_gland2.95587905
13MP0008057_abnormal_DNA_replication2.95150370
14* MP0003698_abnormal_male_reproductive2.91914726
15MP0003880_abnormal_central_pattern2.89327610
16MP0010094_abnormal_chromosome_stability2.88393456
17MP0006292_abnormal_olfactory_placode2.77021782
18MP0008875_abnormal_xenobiotic_pharmacok2.65982053
19MP0009697_abnormal_copulation2.63231914
20MP0000015_abnormal_ear_pigmentation2.51869112
21MP0003121_genomic_imprinting2.51265446
22MP0008058_abnormal_DNA_repair2.41724549
23MP0005377_hearing/vestibular/ear_phenot2.38835189
24MP0003878_abnormal_ear_physiology2.38835189
25MP0005410_abnormal_fertilization2.35055351
26MP0001188_hyperpigmentation2.32778206
27MP0003136_yellow_coat_color2.28533282
28MP0003111_abnormal_nucleus_morphology2.23038249
29MP0003011_delayed_dark_adaptation2.19612751
30MP0005395_other_phenotype2.17854972
31MP0004957_abnormal_blastocyst_morpholog2.12970687
32MP0000516_abnormal_urinary_system2.12812887
33MP0005367_renal/urinary_system_phenotyp2.12812887
34MP0008872_abnormal_physiological_respon2.11395896
35MP0005076_abnormal_cell_differentiation2.00249998
36MP0008877_abnormal_DNA_methylation10.2698110
37MP0003077_abnormal_cell_cycle1.94217752
38MP0005174_abnormal_tail_pigmentation1.80193554
39MP0003787_abnormal_imprinting1.78998421
40MP0006072_abnormal_retinal_apoptosis1.78206701
41MP0005551_abnormal_eye_electrophysiolog1.73444841
42MP0001730_embryonic_growth_arrest1.72845470
43MP0004147_increased_porphyrin_level1.71916316
44MP0002234_abnormal_pharynx_morphology1.69731896
45MP0008789_abnormal_olfactory_epithelium1.68326783
46MP0003890_abnormal_embryonic-extraembry1.66035154
47* MP0002161_abnormal_fertility/fecundity1.65658595
48MP0005623_abnormal_meninges_morphology1.63602368
49MP0002876_abnormal_thyroid_physiology1.61173106
50MP0001661_extended_life_span1.60395304
51MP0002102_abnormal_ear_morphology1.59955911
52MP0004197_abnormal_fetal_growth/weight/1.58994294
53MP0002095_abnormal_skin_pigmentation1.57020962
54MP0000538_abnormal_urinary_bladder1.56033301
55MP0006036_abnormal_mitochondrial_physio1.43643095
56MP0005670_abnormal_white_adipose1.43172687
57MP0002254_reproductive_system_inflammat1.40737654
58MP0008007_abnormal_cellular_replicative1.39267279
59MP0003693_abnormal_embryo_hatching1.36536650
60MP0001119_abnormal_female_reproductive1.35038768
61MP0010307_abnormal_tumor_latency1.34017051
62MP0002138_abnormal_hepatobiliary_system1.32743091
63MP0001905_abnormal_dopamine_level1.29582657
64MP0010352_gastrointestinal_tract_polyps1.29234148
65MP0005253_abnormal_eye_physiology1.22196707
66MP0008932_abnormal_embryonic_tissue1.19585938
67MP0002084_abnormal_developmental_patter1.18844839
68MP0001672_abnormal_embryogenesis/_devel1.18705639
69MP0005380_embryogenesis_phenotype1.18705639
70MP0005646_abnormal_pituitary_gland1.17721384
71MP0000534_abnormal_ureter_morphology1.17226598
72MP0000350_abnormal_cell_proliferation1.16697117
73MP0000778_abnormal_nervous_system1.16211139
74MP0003984_embryonic_growth_retardation1.14623512
75MP0000678_abnormal_parathyroid_gland1.14075091
76MP0002086_abnormal_extraembryonic_tissu1.12543582
77MP0002272_abnormal_nervous_system1.12227625
78MP0002938_white_spotting1.12212615
79MP0005220_abnormal_exocrine_pancreas1.11615242
80MP0003936_abnormal_reproductive_system1.11528163
81MP0001697_abnormal_embryo_size1.10454759
82MP0000631_abnormal_neuroendocrine_gland1.09162855
83MP0002088_abnormal_embryonic_growth/wei1.08958026
84MP0001666_abnormal_nutrient_absorption1.08391583
85MP0002160_abnormal_reproductive_system1.08131710
86MP0003195_calcinosis1.07208538
87MP0003186_abnormal_redox_activity1.06226728
88MP0005647_abnormal_sex_gland1.05859330
89MP0004134_abnormal_chest_morphology1.05349813
90MP0001765_abnormal_ion_homeostasis1.04930977
91MP0009745_abnormal_behavioral_response1.03994788
92MP0002085_abnormal_embryonic_tissue1.03606790
93MP0002184_abnormal_innervation1.03590933
94MP0009672_abnormal_birth_weight1.02438366
95MP0005464_abnormal_platelet_physiology1.02360571
96MP0001501_abnormal_sleep_pattern1.01525695
97MP0002733_abnormal_thermal_nociception0.99979246
98MP0003699_abnormal_female_reproductive0.99974829
99MP0004272_abnormal_basement_membrane0.99568833
100MP0004019_abnormal_vitamin_homeostasis0.99548616
101MP0004808_abnormal_hematopoietic_stem0.99522019
102MP0001970_abnormal_pain_threshold0.99193934
103MP0000569_abnormal_digit_pigmentation0.98702735
104MP0001915_intracranial_hemorrhage0.97545613
105MP0005394_taste/olfaction_phenotype0.95920158
106MP0005499_abnormal_olfactory_system0.95920158
107MP0000537_abnormal_urethra_morphology0.94146326
108MP0003119_abnormal_digestive_system0.93906812
109MP0002168_other_aberrant_phenotype0.93787110
110MP0005171_absent_coat_pigmentation0.92044986
111MP0005187_abnormal_penis_morphology0.91836073
112MP0009250_abnormal_appendicular_skeleto0.91082710
113MP0002653_abnormal_ependyma_morphology0.90310473
114MP0005084_abnormal_gallbladder_morpholo0.88990401
115MP0003705_abnormal_hypodermis_morpholog0.88059520
116MP0000372_irregular_coat_pigmentation0.87849028
117MP0000427_abnormal_hair_cycle0.87619357
118MP0001177_atelectasis0.86801012
119MP0009278_abnormal_bone_marrow0.86438925
120MP0005636_abnormal_mineral_homeostasis0.86299230
121MP0009046_muscle_twitch0.85631356
122MP0002080_prenatal_lethality0.85084290
123MP0000358_abnormal_cell_content/0.85082040
124MP0008775_abnormal_heart_ventricle0.80377360
125MP0001727_abnormal_embryo_implantation0.80236137
126MP0009703_decreased_birth_body0.80115139
127MP0003755_abnormal_palate_morphology0.79291601
128MP0002009_preneoplasia0.77985344
129MP0004215_abnormal_myocardial_fiber0.77805661
130MP0000955_abnormal_spinal_cord0.77301733
131MP0003315_abnormal_perineum_morphology0.74629340
132MP0002735_abnormal_chemical_nociception0.74523936
133MP0006276_abnormal_autonomic_nervous0.74235901
134MP0002064_seizures0.74082350
135MP0010368_abnormal_lymphatic_system0.72746131
136MP0005058_abnormal_lysosome_morphology0.72589882
137MP0001879_abnormal_lymphatic_vessel0.72299379
138MP0000383_abnormal_hair_follicle0.70746522
139MP0003115_abnormal_respiratory_system0.70725822
140MP0003567_abnormal_fetal_cardiomyocyte0.69584350
141MP0003633_abnormal_nervous_system0.69497992
142MP0009333_abnormal_splenocyte_physiolog0.69223846
143MP0005248_abnormal_Harderian_gland0.68553279
144MP0000313_abnormal_cell_death0.68506262
145MP0004043_abnormal_pH_regulation0.68430133
146MP0004185_abnormal_adipocyte_glucose0.68175764
147MP0006035_abnormal_mitochondrial_morpho0.68108768
148MP0002063_abnormal_learning/memory/cond0.66890815
149MP0003937_abnormal_limbs/digits/tail_de0.66372779
150MP0006054_spinal_hemorrhage0.65630493
151MP0003122_maternal_imprinting0.63665143
152MP0003566_abnormal_cell_adhesion0.63320140
153MP0004233_abnormal_muscle_weight0.62716309
154MP0010678_abnormal_skin_adnexa0.62629837
155MP0004264_abnormal_extraembryonic_tissu0.58848428
156MP0003632_abnormal_nervous_system0.57078190
157MP0003861_abnormal_nervous_system0.56424989
158MP0005389_reproductive_system_phenotype0.55981639
159MP0000639_abnormal_adrenal_gland0.55576269
160MP0003091_abnormal_cell_migration0.54723197
161MP0002697_abnormal_eye_size0.54517830
162MP0005621_abnormal_cell_physiology0.52717431
163MP0002019_abnormal_tumor_incidence0.51923947
164MP0005384_cellular_phenotype0.51137478
165MP0004084_abnormal_cardiac_muscle0.46007754
166MP0003879_abnormal_hair_cell0.44062545
167MP0008961_abnormal_basal_metabolism0.43900229
168MP0003942_abnormal_urinary_system0.43152172
169MP0004885_abnormal_endolymph0.42761547
170MP0003941_abnormal_skin_development0.42591325
171MP0006138_congestive_heart_failure0.42537864
172MP0005666_abnormal_adipose_tissue0.42126705
173MP0000647_abnormal_sebaceous_gland0.41354920
174MP0001293_anophthalmia0.41286881
175MP0002092_abnormal_eye_morphology0.41021579
176MP0000013_abnormal_adipose_tissue0.39424250
177MP0010234_abnormal_vibrissa_follicle0.38591746
178MP0002925_abnormal_cardiovascular_devel0.37857882

Predicted human phenotypes

RankGene SetZ-score
1Azoospermia (HP:0000027)8.23216475
2Abnormal spermatogenesis (HP:0008669)7.26463666
3Gonadotropin excess (HP:0000837)7.09098535
4Abnormality of the lower motor neuron (HP:0002366)5.39363675
511 pairs of ribs (HP:0000878)5.28957775
6Intestinal atresia (HP:0011100)5.16671522
7Dyschromatopsia (HP:0007641)5.06060457
8Metaphyseal dysplasia (HP:0100255)4.85262466
9Follicular hyperkeratosis (HP:0007502)4.48967785
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.99472029
11Unilateral renal agenesis (HP:0000122)3.95252458
12Abnormality of the left ventricular outflow tract (HP:0011103)3.94849647
13Subaortic stenosis (HP:0001682)3.94849647
14Metaphyseal cupping (HP:0003021)3.87075515
15Hand muscle atrophy (HP:0009130)3.82343219
16Male infertility (HP:0003251)3.80475634
17Alopecia of scalp (HP:0002293)3.68665147
18Parakeratosis (HP:0001036)3.67134344
19Molar tooth sign on MRI (HP:0002419)3.62256644
20Abnormality of midbrain morphology (HP:0002418)3.62256644
21Absent eyebrow (HP:0002223)3.59039787
22Gonadal dysgenesis (HP:0000133)3.48934322
23Chromsome breakage (HP:0040012)3.45227075
24Male pseudohermaphroditism (HP:0000037)3.32401018
25Missing ribs (HP:0000921)3.29833504
26Abnormal rod and cone electroretinograms (HP:0008323)3.29699448
27Selective tooth agenesis (HP:0001592)3.28475376
28Papillary thyroid carcinoma (HP:0002895)3.28333599
29Gastrointestinal atresia (HP:0002589)3.20101910
30Upper limb amyotrophy (HP:0009129)3.12786487
31Distal upper limb amyotrophy (HP:0007149)3.12786487
32Amyotrophic lateral sclerosis (HP:0007354)3.10044811
33Chromosomal breakage induced by crosslinking agents (HP:0003221)3.09345077
34Vacuolated lymphocytes (HP:0001922)3.08588732
35Erythroderma (HP:0001019)3.07220699
36Facial hemangioma (HP:0000329)3.05628808
37Recurrent corneal erosions (HP:0000495)2.99994212
38Ectopic kidney (HP:0000086)2.95857371
39Upper motor neuron abnormality (HP:0002127)2.94762186
40Absent eyelashes (HP:0000561)2.93786083
41Broad face (HP:0000283)2.92981388
42Spondylolisthesis (HP:0003302)2.91968384
43Shoulder girdle muscle weakness (HP:0003547)2.88411811
44Fibular hypoplasia (HP:0003038)2.84117393
45Cutaneous melanoma (HP:0012056)2.82947994
46Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.82345390
47Reduced antithrombin III activity (HP:0001976)2.79040558
48Type I transferrin isoform profile (HP:0003642)2.74440817
49Colon cancer (HP:0003003)2.72027735
50Pancreatic islet-cell hyperplasia (HP:0004510)2.65142828
51Ectropion (HP:0000656)2.62526347
52Impulsivity (HP:0100710)2.60962007
53Nephronophthisis (HP:0000090)2.60744268
54Renovascular hypertension (HP:0100817)2.59987394
55Pancreatic cysts (HP:0001737)2.52465888
56Pelvic girdle muscle weakness (HP:0003749)2.50348404
57Heterotopia (HP:0002282)2.49182113
58Muscle fibrillation (HP:0010546)2.48383379
59Abnormality of the aortic arch (HP:0012303)2.48139211
60Tongue fasciculations (HP:0001308)2.47478471
61Abnormality of the diencephalon (HP:0010662)2.45667404
62Abnormality of the astrocytes (HP:0100707)2.44884985
63Astrocytoma (HP:0009592)2.44884985
64Melanoma (HP:0002861)2.43563275
65Abnormal sex determination (HP:0012244)2.41951743
66Sex reversal (HP:0012245)2.41951743
67Relative macrocephaly (HP:0004482)2.39526816
68Squamous cell carcinoma (HP:0002860)2.39260308
69Ankle contracture (HP:0006466)2.39196747
70Abnormality of the musculature of the hand (HP:0001421)2.38942833
71Ependymoma (HP:0002888)2.38541936
72Abnormality of the pancreatic islet cells (HP:0006476)2.38369038
73Abnormality of endocrine pancreas physiology (HP:0012093)2.38369038
74Pancreatic fibrosis (HP:0100732)2.38321307
75Infertility (HP:0000789)2.38120504
76Keratitis (HP:0000491)2.36192029
77Type 2 muscle fiber atrophy (HP:0003554)2.30210133
78Chronic hepatic failure (HP:0100626)2.28307491
79Increased nuchal translucency (HP:0010880)2.27157314
80Medulloblastoma (HP:0002885)2.26378628
81Cheilitis (HP:0100825)2.22127850
82Abnormality of the fingertips (HP:0001211)2.21003036
83Small hand (HP:0200055)2.18207040
84Abnormality of dental color (HP:0011073)2.16702504
85Limb-girdle muscle weakness (HP:0003325)2.15841112
86Absent/shortened dynein arms (HP:0200106)2.13921787
87Dynein arm defect of respiratory motile cilia (HP:0012255)2.13921787
88Attenuation of retinal blood vessels (HP:0007843)2.11794417
89Increased CSF lactate (HP:0002490)2.11036221
90Neoplasm of the adrenal cortex (HP:0100641)2.10838783
91Renal dysplasia (HP:0000110)2.10569056
92Abnormality of lateral ventricle (HP:0030047)2.10439315
93Abnormality of the labia minora (HP:0012880)2.10199868
94Abnormality of the musculature of the pelvis (HP:0001469)2.10016468
95Abnormality of the hip-girdle musculature (HP:0001445)2.10016468
96Sandal gap (HP:0001852)2.09741657
97Absent thumb (HP:0009777)2.09230452
98Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.07097598
99Macroorchidism (HP:0000053)2.06795544
100Capillary hemangiomas (HP:0005306)2.06418948
101Facial diplegia (HP:0001349)2.03537773
102Obsessive-compulsive behavior (HP:0000722)2.02424703
103Truncal obesity (HP:0001956)2.01665311
104Rhabdomyosarcoma (HP:0002859)2.01621904
105Hypochromic microcytic anemia (HP:0004840)2.01308249
106Blepharitis (HP:0000498)2.01158369
107Muscle fiber atrophy (HP:0100295)2.00376025
108Difficulty running (HP:0009046)1.99465659
1093-Methylglutaconic aciduria (HP:0003535)1.99210298
110Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98793239
111Abnormal protein N-linked glycosylation (HP:0012347)1.98793239
112Abnormal protein glycosylation (HP:0012346)1.98793239
113Abnormal glycosylation (HP:0012345)1.98793239
114Acanthocytosis (HP:0001927)1.98628668
115Abolished electroretinogram (ERG) (HP:0000550)1.98525380
116Oligodactyly (HP:0012165)1.98328039
117True hermaphroditism (HP:0010459)1.98185790
118Type II lissencephaly (HP:0007260)1.97663046
119Pseudobulbar signs (HP:0002200)1.97645993
120Decreased circulating renin level (HP:0003351)1.96147171
121Medial flaring of the eyebrow (HP:0010747)1.95932339
122Proximal placement of thumb (HP:0009623)1.95362235
123Hyperacusis (HP:0010780)1.95313794
124Hepatocellular necrosis (HP:0001404)1.95028706
125Aplasia/Hypoplasia of the fibula (HP:0006492)1.94568332
126Spinal muscular atrophy (HP:0007269)1.94185030
127Abnormal lung lobation (HP:0002101)1.94122466
128Abnormality of the ileum (HP:0001549)1.92309325
129Long eyelashes (HP:0000527)1.91411538
130Delayed gross motor development (HP:0002194)1.91204404
131Abnormality of chromosome stability (HP:0003220)1.91044174
132Abnormality of placental membranes (HP:0011409)1.90983366
133Amniotic constriction ring (HP:0009775)1.90983366
134Multicystic kidney dysplasia (HP:0000003)1.90809367
135Glioma (HP:0009733)1.90610963
136Prominent nose (HP:0000448)1.90376276
137Sparse eyelashes (HP:0000653)1.89586841
138Nephroblastoma (Wilms tumor) (HP:0002667)1.89334310
139Short tibia (HP:0005736)1.88936018
140Biliary tract neoplasm (HP:0100574)1.88705503
141Large for gestational age (HP:0001520)1.88633810
142Overriding aorta (HP:0002623)1.88194192
143Spontaneous abortion (HP:0005268)1.88038759
144Abnormal drinking behavior (HP:0030082)1.87876065
145Polydipsia (HP:0001959)1.87876065
146Absent hair (HP:0002298)1.87729662
147Thyroid carcinoma (HP:0002890)1.87611102
148Epidermoid cyst (HP:0200040)1.87449909
149Depressed nasal tip (HP:0000437)1.86169404
150Astigmatism (HP:0000483)1.85778173
151Neoplasm of striated muscle (HP:0009728)1.84843578
152Abnormality of the renal medulla (HP:0100957)1.84683249
153Abnormality of the carotid arteries (HP:0005344)1.83878612
154Constricted visual fields (HP:0001133)1.83316403
155Decreased central vision (HP:0007663)1.82745885
156Atrophy/Degeneration involving motor neurons (HP:0007373)1.82376579
157Hypopigmentation of the fundus (HP:0007894)1.82255793
158Urethral obstruction (HP:0000796)1.82143129
159Deviation of the thumb (HP:0009603)1.81950504
160Increased serum pyruvate (HP:0003542)1.81400794
161Mitochondrial inheritance (HP:0001427)1.81252039
162Increased serum lactate (HP:0002151)1.80860029
163Thin ribs (HP:0000883)1.79798739
164Renal cortical cysts (HP:0000803)1.78975488
165Narrow palate (HP:0000189)1.78734318
166Entropion (HP:0000621)1.78208826
167Polycystic ovaries (HP:0000147)1.75967130
168Abnormality of homocysteine metabolism (HP:0010919)1.73663484
169Homocystinuria (HP:0002156)1.73663484
170Aplasia/Hypoplasia of the tibia (HP:0005772)1.73427809
171Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.72845369
172Embryonal renal neoplasm (HP:0011794)1.72817319
173Tubulointerstitial nephritis (HP:0001970)1.72591843
174Hepatic necrosis (HP:0002605)1.72208652
175Shawl scrotum (HP:0000049)1.71556736
176Abnormality of the calcaneus (HP:0008364)1.71160740
177Acute necrotizing encephalopathy (HP:0006965)1.71157270
178Volvulus (HP:0002580)1.70497224
179Vitreoretinal degeneration (HP:0000655)1.69655638
180Renal duplication (HP:0000075)1.68972759
181Primary amenorrhea (HP:0000786)1.68956969
182Skull defect (HP:0001362)1.68631413
183Aganglionic megacolon (HP:0002251)1.68592640
184Increased mean platelet volume (HP:0011877)1.68451721
185Aplasia/Hypoplasia involving the musculature (HP:0001460)1.67974048
186Mesangial abnormality (HP:0001966)1.67218607
187Hyporeflexia of lower limbs (HP:0002600)1.66831230
188Keratoconus (HP:0000563)1.66732823
189Increased corneal curvature (HP:0100692)1.66732823
190Abnormality of male internal genitalia (HP:0000022)1.66496746
191Low anterior hairline (HP:0000294)1.66200501
192Neoplasm of the lung (HP:0100526)1.64187150
193Abnormality of the frontal sinuses (HP:0002687)1.63866490
194Beaking of vertebral bodies (HP:0004568)1.63813009

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.07265987
2CDC74.58377189
3ACVR1B4.49449075
4BRD44.18744086
5MST44.12855093
6FRK3.60541440
7NUAK13.58280009
8PDK42.78265956
9PDK32.78265956
10VRK22.75504452
11EIF2AK32.54475868
12MAPK132.52865818
13WEE12.23694979
14NEK22.13116513
15ZAK2.11643334
16ADRBK22.08864384
17PINK12.07248291
18CDK92.01869768
19NME11.99675662
20MAP3K41.96352314
21TYRO31.74893577
22VRK11.72901934
23ICK1.66057524
24CDK71.54574267
25PDK21.51777357
26PRKD31.50590561
27WNK31.48806353
28PLK11.45600101
29ATR1.45410565
30CHEK11.40636275
31EIF2AK11.40124292
32MTOR1.33933980
33PLK41.32903687
34TAF11.26623416
35MKNK21.25004213
36STK38L1.22767279
37TRIM281.22451048
38MARK11.22385994
39STK391.21353508
40PKN21.19747638
41PTK2B1.19443378
42CDK41.17713768
43PKN11.16589808
44ATM1.14575239
45MELK1.13657029
46BRSK21.12804620
47OXSR11.12347524
48CDC42BPA1.10631393
49TAOK31.09341457
50TTK1.08998386
51KIT1.07872350
52GRK51.05969680
53PHKG11.01869383
54PHKG21.01869383
55WNK11.01845412
56RPS6KB20.98639804
57STK30.98438928
58CASK0.95483199
59CCNB10.95386824
60CAMK1D0.93057315
61SCYL20.91119214
62GRK10.90532246
63PLK20.90511876
64MYLK0.90126292
65CHEK20.89553962
66DYRK20.89362704
67PNCK0.89190564
68NEK10.87173740
69PBK0.87123900
70CDK20.87061085
71FLT30.86979153
72RIPK10.86761436
73STK160.86043078
74PAK40.84858925
75PIM20.84323551
76BMPR1B0.81648246
77MAPKAPK50.79219966
78EIF2AK20.77911921
79CSNK1G30.76313979
80CDK10.76279210
81MET0.76205022
82MAP3K100.75566413
83STK240.74358416
84RET0.74269373
85MKNK10.73777577
86MAP3K20.73549246
87EEF2K0.72939897
88INSRR0.71976948
89PRKCI0.71557220
90CAMK40.67814915
91MARK30.66421443
92BRSK10.66263035
93PTK60.65941587
94CSNK1A1L0.65905231
95ERBB30.64660862
96MAP3K70.63044551
97TGFBR10.62117613
98EPHA40.61549410
99TLK10.60434196
100PLK30.59979323
101CSNK1G10.59893263
102CAMK1G0.59127456
103DYRK1A0.58630745
104TRIB30.58363061
105PDGFRA0.58334381
106LATS10.57529983
107ADRBK10.57277508
108MAP2K60.57248379
109BCKDK0.55633516
110GSK3B0.55409147
111PRKDC0.55294587
112MAP4K20.54954181
113AURKB0.54899258
114KSR10.53786232
115CSNK1G20.53707485
116TESK10.53687678
117LIMK10.52722167
118TEC0.51826900
119STK40.51440217
120CSNK1D0.51280702
121MAP3K90.49185813
122PRKCQ0.48984639
123CSNK1E0.47976262
124IKBKB0.47605962
125PRKCE0.47550472
126MAPK80.46826505
127BMX0.46008896
128MAPK140.45753934
129MAP2K70.44923751
130PASK0.44522698
131WNK40.44423489
132PDGFRB0.44160468
133MAP3K60.43717466
134MAP2K40.43354664
135TIE10.43312133
136FGFR10.42983684
137SRPK10.42769319
138CDK60.42577677
139PRKCG0.42378718
140PAK30.40573469
141MAP3K50.39788916
142LATS20.39590872
143TSSK60.38682940
144TXK0.38673989
145CAMK2D0.38424784
146ALK0.38324009
147ERBB40.38038636
148CAMK10.38024829
149FER0.36527002
150STK110.35535500
151MAPK70.35135392
152CAMK2A0.34979377
153BCR0.34968519
154BUB10.34967634
155PTK20.34664633
156SGK10.34636328
157CSNK2A20.34181955
158MAPK10.32813307
159DAPK10.32289605
160CSNK2A10.31823162
161EPHA20.31674117
162MAPKAPK30.30523759
163OBSCN0.29986276
164RPS6KB10.29162859
165DAPK20.29061957
166EGFR0.28949111
167KSR20.28276067

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.81055074
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030085.25191644
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.56655401
4RNA transport_Homo sapiens_hsa030133.45099330
5mRNA surveillance pathway_Homo sapiens_hsa030153.36146316
6* Basal transcription factors_Homo sapiens_hsa030223.33751824
7Dorso-ventral axis formation_Homo sapiens_hsa043202.96182658
8Cell cycle_Homo sapiens_hsa041102.93734587
9DNA replication_Homo sapiens_hsa030302.88701739
10Homologous recombination_Homo sapiens_hsa034402.82989682
11Mismatch repair_Homo sapiens_hsa034302.79626312
12Spliceosome_Homo sapiens_hsa030402.66297223
13Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.58112196
14Lysine degradation_Homo sapiens_hsa003102.54995091
15RNA polymerase_Homo sapiens_hsa030202.53226924
16Fanconi anemia pathway_Homo sapiens_hsa034602.36823103
17Nucleotide excision repair_Homo sapiens_hsa034202.32357901
18Oxidative phosphorylation_Homo sapiens_hsa001902.31691510
19Oocyte meiosis_Homo sapiens_hsa041142.31444674
20Parkinsons disease_Homo sapiens_hsa050122.15452594
21Steroid biosynthesis_Homo sapiens_hsa001001.94948416
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92682538
23Non-homologous end-joining_Homo sapiens_hsa034501.87183177
24Protein export_Homo sapiens_hsa030601.83535391
25Base excision repair_Homo sapiens_hsa034101.80223560
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.78840529
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76936945
28Selenocompound metabolism_Homo sapiens_hsa004501.72321105
29Butanoate metabolism_Homo sapiens_hsa006501.62968777
30RNA degradation_Homo sapiens_hsa030181.60416779
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.49103138
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45342061
33TGF-beta signaling pathway_Homo sapiens_hsa043501.38904450
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38637779
35Thyroid cancer_Homo sapiens_hsa052161.35007304
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34105969
37Alzheimers disease_Homo sapiens_hsa050101.32590176
38Fatty acid elongation_Homo sapiens_hsa000621.31007992
39One carbon pool by folate_Homo sapiens_hsa006701.28908559
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.26990086
41Sulfur metabolism_Homo sapiens_hsa009201.24885798
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23880040
43Peroxisome_Homo sapiens_hsa041461.23749065
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22895490
45Phototransduction_Homo sapiens_hsa047441.22365354
46Glutathione metabolism_Homo sapiens_hsa004801.20904410
47Herpes simplex infection_Homo sapiens_hsa051681.20192706
48Nitrogen metabolism_Homo sapiens_hsa009101.18599413
49Proteasome_Homo sapiens_hsa030501.17395543
50Propanoate metabolism_Homo sapiens_hsa006401.15903987
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12491452
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10754255
53Adherens junction_Homo sapiens_hsa045201.09897927
54Epstein-Barr virus infection_Homo sapiens_hsa051691.08911255
55Small cell lung cancer_Homo sapiens_hsa052221.08059541
56Hippo signaling pathway_Homo sapiens_hsa043901.05248712
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04154856
58Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02807473
59Collecting duct acid secretion_Homo sapiens_hsa049661.02791938
60Olfactory transduction_Homo sapiens_hsa047401.00543155
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.99742650
62Notch signaling pathway_Homo sapiens_hsa043300.99476486
63Tight junction_Homo sapiens_hsa045300.98822391
64Fatty acid metabolism_Homo sapiens_hsa012120.97824787
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95244221
66Pyrimidine metabolism_Homo sapiens_hsa002400.95132003
67HTLV-I infection_Homo sapiens_hsa051660.95027148
68Ribosome_Homo sapiens_hsa030100.94767293
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90368795
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90333167
71Regulation of autophagy_Homo sapiens_hsa041400.88505934
72Glycerolipid metabolism_Homo sapiens_hsa005610.87482462
73Fatty acid biosynthesis_Homo sapiens_hsa000610.85566222
74Chemical carcinogenesis_Homo sapiens_hsa052040.85455940
75Cardiac muscle contraction_Homo sapiens_hsa042600.79741627
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79486505
77Antigen processing and presentation_Homo sapiens_hsa046120.76890494
78Viral carcinogenesis_Homo sapiens_hsa052030.76380203
79Metabolic pathways_Homo sapiens_hsa011000.76351494
80MicroRNAs in cancer_Homo sapiens_hsa052060.75756150
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.75519551
82Influenza A_Homo sapiens_hsa051640.74676530
83Pentose phosphate pathway_Homo sapiens_hsa000300.72871685
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72485198
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.72439981
86Purine metabolism_Homo sapiens_hsa002300.72087947
87ECM-receptor interaction_Homo sapiens_hsa045120.71130923
88Folate biosynthesis_Homo sapiens_hsa007900.69964259
89p53 signaling pathway_Homo sapiens_hsa041150.69459879
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68788721
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68675101
92Circadian rhythm_Homo sapiens_hsa047100.67398311
93Ether lipid metabolism_Homo sapiens_hsa005650.66547170
94Arginine and proline metabolism_Homo sapiens_hsa003300.66318606
95Tryptophan metabolism_Homo sapiens_hsa003800.65570076
96Other glycan degradation_Homo sapiens_hsa005110.65527663
97Pancreatic cancer_Homo sapiens_hsa052120.65440260
98Taste transduction_Homo sapiens_hsa047420.64980184
99Colorectal cancer_Homo sapiens_hsa052100.61812236
100VEGF signaling pathway_Homo sapiens_hsa043700.61051934
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59793138
102Sphingolipid metabolism_Homo sapiens_hsa006000.58435453
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58260218
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57423561
105FoxO signaling pathway_Homo sapiens_hsa040680.57259935
106Linoleic acid metabolism_Homo sapiens_hsa005910.56755154
107Primary immunodeficiency_Homo sapiens_hsa053400.54610592
108Prostate cancer_Homo sapiens_hsa052150.54593058
109Pathways in cancer_Homo sapiens_hsa052000.53924952
110Retinol metabolism_Homo sapiens_hsa008300.53757421
111Focal adhesion_Homo sapiens_hsa045100.52701307
112Glucagon signaling pathway_Homo sapiens_hsa049220.52680867
113Fatty acid degradation_Homo sapiens_hsa000710.52413634
114Hedgehog signaling pathway_Homo sapiens_hsa043400.51777305
115ABC transporters_Homo sapiens_hsa020100.50864682
116mTOR signaling pathway_Homo sapiens_hsa041500.49915476
117Amoebiasis_Homo sapiens_hsa051460.49441954
118Pyruvate metabolism_Homo sapiens_hsa006200.49266266
119beta-Alanine metabolism_Homo sapiens_hsa004100.48237845
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48047303
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47610562
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47308515
123Basal cell carcinoma_Homo sapiens_hsa052170.47065442
124Renal cell carcinoma_Homo sapiens_hsa052110.46232651
125Caffeine metabolism_Homo sapiens_hsa002320.46075219
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.45331727
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42839549
128N-Glycan biosynthesis_Homo sapiens_hsa005100.40120185
129AMPK signaling pathway_Homo sapiens_hsa041520.39827669
130Vitamin digestion and absorption_Homo sapiens_hsa049770.39215739
131Proteoglycans in cancer_Homo sapiens_hsa052050.38407060
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38132651
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38047448
134Serotonergic synapse_Homo sapiens_hsa047260.37871306
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36507410
136Arachidonic acid metabolism_Homo sapiens_hsa005900.36290530
137Estrogen signaling pathway_Homo sapiens_hsa049150.35817960
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34800950
139Huntingtons disease_Homo sapiens_hsa050160.34646504
140Axon guidance_Homo sapiens_hsa043600.34397387
141Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33158196
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32714274
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.31938145
144Choline metabolism in cancer_Homo sapiens_hsa052310.31926415
145Wnt signaling pathway_Homo sapiens_hsa043100.31896961
146Mineral absorption_Homo sapiens_hsa049780.29704253
147Long-term potentiation_Homo sapiens_hsa047200.29295651
148Glioma_Homo sapiens_hsa052140.29082741
149Non-small cell lung cancer_Homo sapiens_hsa052230.28380109
150Circadian entrainment_Homo sapiens_hsa047130.27064964
151Legionellosis_Homo sapiens_hsa051340.26642688
152Biosynthesis of amino acids_Homo sapiens_hsa012300.26622223
153Alcoholism_Homo sapiens_hsa050340.26041584
154Ovarian steroidogenesis_Homo sapiens_hsa049130.25949823
155Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25287371
156Nicotine addiction_Homo sapiens_hsa050330.24219141
157Sulfur relay system_Homo sapiens_hsa041220.24206654
158Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23606377
159Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23417268
160HIF-1 signaling pathway_Homo sapiens_hsa040660.23101809
161Inositol phosphate metabolism_Homo sapiens_hsa005620.23014634
162Endocytosis_Homo sapiens_hsa041440.22859907
163Fat digestion and absorption_Homo sapiens_hsa049750.22703104
164Toxoplasmosis_Homo sapiens_hsa051450.22007914
165Starch and sucrose metabolism_Homo sapiens_hsa005000.21959353
166Insulin resistance_Homo sapiens_hsa049310.21325122
167Endometrial cancer_Homo sapiens_hsa052130.21024899
168Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20272422
169Cyanoamino acid metabolism_Homo sapiens_hsa004600.17929863
170cAMP signaling pathway_Homo sapiens_hsa040240.16430333

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