TAF7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.78228263
2rRNA modification (GO:0000154)4.65227003
3pyrimidine nucleobase catabolic process (GO:0006208)4.57918426
4rRNA methylation (GO:0031167)4.30715057
5chromatin remodeling at centromere (GO:0031055)4.22133740
6DNA replication checkpoint (GO:0000076)4.19921865
7nuclear pore organization (GO:0006999)4.19867807
8CENP-A containing nucleosome assembly (GO:0034080)4.19195212
9purine nucleobase biosynthetic process (GO:0009113)4.13148836
10metaphase plate congression (GO:0051310)4.12720035
11nucleobase biosynthetic process (GO:0046112)4.11793438
12DNA replication initiation (GO:0006270)4.10699211
13nuclear pore complex assembly (GO:0051292)3.91195608
14protein K6-linked ubiquitination (GO:0085020)3.91105988
15intraciliary transport (GO:0042073)3.89676651
16ribosome assembly (GO:0042255)3.85058115
17nonmotile primary cilium assembly (GO:0035058)3.84521662
18ribosome biogenesis (GO:0042254)3.82937865
19positive regulation of mitochondrial fission (GO:0090141)3.77264694
20IMP biosynthetic process (GO:0006188)3.76741065
21DNA replication-independent nucleosome assembly (GO:0006336)3.74536200
22DNA replication-independent nucleosome organization (GO:0034724)3.74536200
23attachment of spindle microtubules to kinetochore (GO:0008608)3.74249413
24DNA double-strand break processing (GO:0000729)3.73176819
25cullin deneddylation (GO:0010388)3.72741816
26protein localization to kinetochore (GO:0034501)3.66241349
27kinetochore organization (GO:0051383)3.66126565
28histone H2A acetylation (GO:0043968)3.64797303
29DNA replication-dependent nucleosome organization (GO:0034723)3.63710549
30DNA replication-dependent nucleosome assembly (GO:0006335)3.63710549
31DNA strand elongation involved in DNA replication (GO:0006271)3.63615582
32histone exchange (GO:0043486)3.62767503
33mitotic nuclear envelope disassembly (GO:0007077)3.60572706
34regulation of helicase activity (GO:0051095)3.59559868
35establishment of chromosome localization (GO:0051303)3.59459761
36regulation of posttranscriptional gene silencing (GO:0060147)3.58869194
37regulation of gene silencing by miRNA (GO:0060964)3.58869194
38regulation of gene silencing by RNA (GO:0060966)3.58869194
39maturation of 5.8S rRNA (GO:0000460)3.58545596
40presynaptic membrane assembly (GO:0097105)3.57215272
41kinetochore assembly (GO:0051382)3.55451667
42telomere maintenance via semi-conservative replication (GO:0032201)3.54950497
43DNA strand elongation (GO:0022616)3.54483788
44nucleobase catabolic process (GO:0046113)3.53545577
45regulation of double-strand break repair via homologous recombination (GO:0010569)3.53520930
46proteasome assembly (GO:0043248)3.51916709
47regulation of spindle organization (GO:0090224)3.50667283
48formation of translation preinitiation complex (GO:0001731)3.47161802
49somatic hypermutation of immunoglobulin genes (GO:0016446)3.45267276
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.45267276
517-methylguanosine mRNA capping (GO:0006370)3.44718739
52resolution of meiotic recombination intermediates (GO:0000712)3.41771312
53telomere maintenance via recombination (GO:0000722)3.41044858
547-methylguanosine RNA capping (GO:0009452)3.40514279
55RNA capping (GO:0036260)3.40514279
56ribonucleoprotein complex biogenesis (GO:0022613)3.39455932
57positive regulation of chromosome segregation (GO:0051984)3.38979860
58maturation of SSU-rRNA (GO:0030490)3.37093405
59regulation of nuclear cell cycle DNA replication (GO:0033262)3.36418436
60nuclear envelope disassembly (GO:0051081)3.34440972
61membrane disassembly (GO:0030397)3.34440972
62protein localization to cilium (GO:0061512)3.31407097
63transcription from RNA polymerase I promoter (GO:0006360)3.31363444
64neural tube formation (GO:0001841)3.31147295
65regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.30666158
66protein deneddylation (GO:0000338)3.30607136
67regulation of cilium movement (GO:0003352)3.30601726
68transcription-coupled nucleotide-excision repair (GO:0006283)3.30130675
69DNA damage response, detection of DNA damage (GO:0042769)3.29794260
70negative regulation of DNA recombination (GO:0045910)3.29494247
71IMP metabolic process (GO:0046040)3.28300159
72mitotic recombination (GO:0006312)3.26962334
73meiotic chromosome segregation (GO:0045132)3.26874033
74ribosomal large subunit biogenesis (GO:0042273)3.26663807
75termination of RNA polymerase I transcription (GO:0006363)3.25098115
76rRNA processing (GO:0006364)3.22041548
77spliceosomal snRNP assembly (GO:0000387)3.21433991
78presynaptic membrane organization (GO:0097090)3.20980885
79spindle checkpoint (GO:0031577)3.19938695
80transcription elongation from RNA polymerase I promoter (GO:0006362)3.19741049
81spermatid nucleus differentiation (GO:0007289)3.19287476
82cilium morphogenesis (GO:0060271)3.19246634
83respiratory chain complex IV assembly (GO:0008535)3.18031074
84DNA integration (GO:0015074)3.17135380
85protein localization to chromosome, centromeric region (GO:0071459)3.17044010
86transcription initiation from RNA polymerase I promoter (GO:0006361)3.17032780
87telomere maintenance via telomere lengthening (GO:0010833)3.16030492
88pore complex assembly (GO:0046931)3.13150124
89positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.11743132
90positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.11743132
91positive regulation of mitotic sister chromatid separation (GO:1901970)3.11743132
92rRNA metabolic process (GO:0016072)3.11583599
93regulation of mitotic spindle organization (GO:0060236)3.11149151
94maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.08428209
95spliceosomal complex assembly (GO:0000245)3.06398566
96negative regulation of chromosome segregation (GO:0051985)3.05010809
97regulation of mitotic metaphase/anaphase transition (GO:0030071)3.03959441
98negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03691826
99negative regulation of sister chromatid segregation (GO:0033046)3.03691826
100negative regulation of mitotic sister chromatid separation (GO:2000816)3.03691826
101negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03691826
102DNA unwinding involved in DNA replication (GO:0006268)3.03567678
103mitotic spindle checkpoint (GO:0071174)3.02618564
104regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.01913192
105ribosomal small subunit assembly (GO:0000028)3.01442555
106negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.01051610
107pyrimidine dimer repair (GO:0006290)3.00958983
108positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.00119586
109mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.00119586
110response to pheromone (GO:0019236)2.99796990
111termination of RNA polymerase III transcription (GO:0006386)2.99774270
112transcription elongation from RNA polymerase III promoter (GO:0006385)2.99774270
113establishment of protein localization to mitochondrial membrane (GO:0090151)2.99011045
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.98816339
115preassembly of GPI anchor in ER membrane (GO:0016254)2.98753925
116mitotic sister chromatid segregation (GO:0000070)2.97624355
117transcription elongation from RNA polymerase II promoter (GO:0006368)2.97012531
118spindle assembly checkpoint (GO:0071173)2.96579520
119regulation of mitotic sister chromatid separation (GO:0010965)2.96098081
120regulation of mitotic sister chromatid segregation (GO:0033047)2.96098081
121regulation of sister chromatid segregation (GO:0033045)2.96098081
122mitotic spindle assembly checkpoint (GO:0007094)2.95080092
123regulation of chromosome segregation (GO:0051983)2.94918045
124piRNA metabolic process (GO:0034587)2.94740764
125mismatch repair (GO:0006298)2.94647384
126negative regulation of transcription regulatory region DNA binding (GO:2000678)2.93691757
127regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.93029710
128neuron cell-cell adhesion (GO:0007158)2.89915336
129DNA deamination (GO:0045006)2.89860174
130epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88158330
131RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.87990830
132tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.87990830
133somite development (GO:0061053)2.84790484
134sequestering of actin monomers (GO:0042989)2.83924551
135photoreceptor cell maintenance (GO:0045494)2.82190384
136mannosylation (GO:0097502)2.81186608
137epithelial cilium movement (GO:0003351)2.79802700
138fatty acid elongation (GO:0030497)2.79795608
139ubiquinone metabolic process (GO:0006743)2.79380011
140regulation of feeding behavior (GO:0060259)2.78215756
141histone H2A ubiquitination (GO:0033522)2.78102662
142water-soluble vitamin biosynthetic process (GO:0042364)2.76751305
143platelet dense granule organization (GO:0060155)2.75940883
144positive regulation of oligodendrocyte differentiation (GO:0048714)2.75701888
145GPI anchor metabolic process (GO:0006505)2.75640892
146behavioral response to nicotine (GO:0035095)2.75368840
147protein complex biogenesis (GO:0070271)2.74479778
148retinal ganglion cell axon guidance (GO:0031290)2.72904199
149mitochondrial respiratory chain complex I assembly (GO:0032981)2.70247390
150NADH dehydrogenase complex assembly (GO:0010257)2.70247390
151mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70247390
152regulation of development, heterochronic (GO:0040034)2.66540591
153regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.66423692
154regulation of mitotic spindle checkpoint (GO:1903504)2.66423692
155calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.65425080
156DNA ligation (GO:0006266)2.65009416
157nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.64998098
158branched-chain amino acid catabolic process (GO:0009083)2.63389985
159mitochondrial respiratory chain complex assembly (GO:0033108)2.61315835
160cytochrome complex assembly (GO:0017004)2.60670179
161L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.59617970
162ubiquinone biosynthetic process (GO:0006744)2.59581943
163neuron fate determination (GO:0048664)2.59336839
164protein neddylation (GO:0045116)2.59058328
165C-terminal protein lipidation (GO:0006501)2.58477005
166C-terminal protein amino acid modification (GO:0018410)2.58355078
167organelle disassembly (GO:1903008)2.58297112
168regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.57773093
169olfactory bulb development (GO:0021772)2.57149270
170exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.55849642
171cerebral cortex radially oriented cell migration (GO:0021799)2.53972855
172short-term memory (GO:0007614)2.53879919
173protein-cofactor linkage (GO:0018065)2.52398581
174negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.51845417
175protein K11-linked ubiquitination (GO:0070979)2.51110521
176G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50877755
177axoneme assembly (GO:0035082)2.50534592
178regulation of collateral sprouting (GO:0048670)2.49626442
179cilium organization (GO:0044782)2.47928052
180protein polyglutamylation (GO:0018095)2.47877317
181regulation of meiosis I (GO:0060631)2.47216969
182GPI anchor biosynthetic process (GO:0006506)2.46968321
183mechanosensory behavior (GO:0007638)2.46895788
184negative regulation of oligodendrocyte differentiation (GO:0048715)2.46445505
185cilium assembly (GO:0042384)2.45985712
186anterograde synaptic vesicle transport (GO:0048490)2.45686362
187RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.44453840
188retinal cone cell development (GO:0046549)2.42326725
189metallo-sulfur cluster assembly (GO:0031163)2.42079077
190iron-sulfur cluster assembly (GO:0016226)2.42079077
191ribonucleoprotein complex disassembly (GO:0032988)2.41529298
192limb bud formation (GO:0060174)2.39745237
193postsynaptic membrane organization (GO:0001941)2.39662069
194synapsis (GO:0007129)2.39192941
195regulation of microtubule-based movement (GO:0060632)2.37358912
196negative regulation of DNA-dependent DNA replication (GO:2000104)2.36319449
197regulation of mitochondrial fission (GO:0090140)2.35289068
198positive regulation of amino acid transport (GO:0051957)2.34866566
199lipid particle organization (GO:0034389)2.34287286

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.99287042
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.12551792
3ZNF274_21170338_ChIP-Seq_K562_Hela3.71572707
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.64297598
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.47043552
6IGF1R_20145208_ChIP-Seq_DFB_Human3.41046479
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.32743514
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.16483529
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.14619864
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.06385145
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.01488080
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94541107
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89438914
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82901392
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78659056
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68413384
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.68116828
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.67451129
19TAF15_26573619_Chip-Seq_HEK293_Human2.66834917
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.64314337
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59909278
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.54057097
23VDR_22108803_ChIP-Seq_LS180_Human2.44964337
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43647808
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.43369904
26EWS_26573619_Chip-Seq_HEK293_Human2.37587070
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35670496
28FUS_26573619_Chip-Seq_HEK293_Human2.35434537
29NANOG_18555785_ChIP-Seq_MESCs_Mouse2.28550486
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.28263034
31VDR_23849224_ChIP-Seq_CD4+_Human2.27971257
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.26954122
33SALL1_21062744_ChIP-ChIP_HESCs_Human2.15890338
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.15172835
35KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.07045019
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.07045019
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.07045019
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05648723
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03089147
40XRN2_22483619_ChIP-Seq_HELA_Human2.02686916
41GBX2_23144817_ChIP-Seq_PC3_Human2.01661887
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96893720
43AR_21909140_ChIP-Seq_LNCAP_Human1.96247921
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93854764
45ELK1_19687146_ChIP-ChIP_HELA_Human1.90387668
46FOXP3_21729870_ChIP-Seq_TREG_Human1.89907187
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89383721
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.86734365
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85471992
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83035353
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83033337
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.82814097
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.79709467
54P300_19829295_ChIP-Seq_ESCs_Human1.78416913
55SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.78138200
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76317356
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.73387639
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73143388
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72375138
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72245688
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.71724122
62EZH2_22144423_ChIP-Seq_EOC_Human1.70864963
63DCP1A_22483619_ChIP-Seq_HELA_Human1.68533458
64TTF2_22483619_ChIP-Seq_HELA_Human1.68467005
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67839900
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.67625455
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66619109
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64576611
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63758680
70* GABP_19822575_ChIP-Seq_HepG2_Human1.63751249
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.63428185
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.62537553
73NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.61459506
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59308959
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54672050
76EGR1_19374776_ChIP-ChIP_THP-1_Human1.49535422
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48615981
78TCF3_18692474_ChIP-Seq_MEFs_Mouse1.45691003
79ER_23166858_ChIP-Seq_MCF-7_Human1.45576662
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43875281
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43187941
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.41357386
83RNF2_27304074_Chip-Seq_NSC_Mouse1.40687127
84CBP_20019798_ChIP-Seq_JUKART_Human1.39989131
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39989131
86NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.35604065
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35590827
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.33489715
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32468215
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32321032
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32276633
92SOX2_16153702_ChIP-ChIP_HESCs_Human1.30665058
93* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.29416009
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27242926
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27219054
96TCF3_18692474_ChIP-Seq_MESCs_Mouse1.26906349
97KDM5A_27292631_Chip-Seq_BREAST_Human1.26829480
98CBX2_27304074_Chip-Seq_ESCs_Mouse1.25725379
99PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25652075
100ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24679495
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24674689
102PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23994833
103TP53_22573176_ChIP-Seq_HFKS_Human1.23773131
104CIITA_25753668_ChIP-Seq_RAJI_Human1.23245262
105* SMAD4_21799915_ChIP-Seq_A2780_Human1.19541066
106RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15480288
107* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14684190
108PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14393015
109NOTCH1_21737748_ChIP-Seq_TLL_Human1.11877658
110KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11682726
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11594644
112* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11272224
113SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.08770842
114KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06866273
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06474918
116SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06464594
117KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06360508
118MYC_18940864_ChIP-ChIP_HL60_Human1.06054186
119TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06042796
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05679559
121TFEB_21752829_ChIP-Seq_HELA_Human1.04659200
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03799679
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03062370
124IRF1_19129219_ChIP-ChIP_H3396_Human1.02513891
125HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01549119
126SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01397161
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00887840
128AR_25329375_ChIP-Seq_VCAP_Human1.00388692
129NANOG_21062744_ChIP-ChIP_HESCs_Human1.00320220
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00135209
131PIAS1_25552417_ChIP-Seq_VCAP_Human1.00126001
132SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98973088
133SMAD3_21741376_ChIP-Seq_EPCs_Human0.98839206
134RUNX2_22187159_ChIP-Seq_PCA_Human0.97349460
135ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96573603
136BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95659644
137NANOG_19829295_ChIP-Seq_ESCs_Human0.94836837
138SOX2_19829295_ChIP-Seq_ESCs_Human0.94836837
139SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94526837
140STAT3_23295773_ChIP-Seq_U87_Human0.94372096
141BCAT_22108803_ChIP-Seq_LS180_Human0.94053244
142CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93859461
143SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93816384
144POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93808241
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93213345
146ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92893014
147NANOG_18692474_ChIP-Seq_MEFs_Mouse0.91430436
148POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91326730
149TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91326730
150* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91108705
151NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91070754
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90702677
153NANOG_18555785_Chip-Seq_ESCs_Mouse0.90177526
154* ELK1_22589737_ChIP-Seq_MCF10A_Human0.87953754
155KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85853119
156SOX2_18692474_ChIP-Seq_MESCs_Mouse0.85306671
157NANOG_16153702_ChIP-ChIP_HESCs_Human0.84629172
158SOX17_20123909_ChIP-Seq_XEN_Mouse0.84489880

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.23659589
2MP0010094_abnormal_chromosome_stability4.49550456
3MP0008057_abnormal_DNA_replication4.34064084
4MP0004957_abnormal_blastocyst_morpholog4.23546610
5MP0003111_abnormal_nucleus_morphology4.23315051
6MP0003077_abnormal_cell_cycle3.88131723
7MP0008058_abnormal_DNA_repair3.69874419
8MP0008877_abnormal_DNA_methylation3.22300201
9MP0001529_abnormal_vocalization3.16249180
10MP0008007_abnormal_cellular_replicative3.11284283
11MP0003880_abnormal_central_pattern3.02133608
12MP0001984_abnormal_olfaction2.98096279
13MP0008789_abnormal_olfactory_epithelium2.85642845
14MP0002102_abnormal_ear_morphology2.81161590
15MP0003123_paternal_imprinting2.81092523
16MP0003718_maternal_effect2.66481120
17MP0008932_abnormal_embryonic_tissue2.61664199
18MP0003786_premature_aging2.52348036
19MP0005394_taste/olfaction_phenotype2.50225065
20MP0005499_abnormal_olfactory_system2.50225065
21MP0003122_maternal_imprinting2.44881745
22MP0001730_embryonic_growth_arrest2.19791465
23MP0006292_abnormal_olfactory_placode2.19263149
24MP0000350_abnormal_cell_proliferation2.12420920
25MP0006276_abnormal_autonomic_nervous2.12019952
26MP0002736_abnormal_nociception_after1.91637432
27MP0005253_abnormal_eye_physiology1.87945172
28MP0001968_abnormal_touch/_nociception1.84129639
29MP0000778_abnormal_nervous_system1.83959130
30MP0003806_abnormal_nucleotide_metabolis1.83565832
31MP0010352_gastrointestinal_tract_polyps1.81321159
32MP0002234_abnormal_pharynx_morphology1.76215821
33MP0001672_abnormal_embryogenesis/_devel1.73486644
34MP0005380_embryogenesis_phenotype1.73486644
35MP0003941_abnormal_skin_development1.68953748
36MP0003121_genomic_imprinting1.68701787
37MP0005423_abnormal_somatic_nervous1.67941118
38MP0010307_abnormal_tumor_latency1.65986031
39MP0003890_abnormal_embryonic-extraembry1.63022555
40MP0002210_abnormal_sex_determination1.62113695
41MP0005551_abnormal_eye_electrophysiolog1.61945608
42MP0001697_abnormal_embryo_size1.57862629
43MP0004142_abnormal_muscle_tone1.55114985
44MP0002085_abnormal_embryonic_tissue1.53861718
45MP0002084_abnormal_developmental_patter1.50860292
46MP0004133_heterotaxia1.50838690
47MP0002822_catalepsy1.47976625
48MP0003315_abnormal_perineum_morphology1.45476147
49MP0004270_analgesia1.44700163
50MP0009046_muscle_twitch1.43533385
51MP0003984_embryonic_growth_retardation1.42792780
52MP0001293_anophthalmia1.41333167
53MP0000631_abnormal_neuroendocrine_gland1.40229588
54MP0002088_abnormal_embryonic_growth/wei1.39645781
55MP0001929_abnormal_gametogenesis1.36505301
56MP0006035_abnormal_mitochondrial_morpho1.36397607
57MP0002272_abnormal_nervous_system1.35583845
58MP0001486_abnormal_startle_reflex1.35551269
59MP0001145_abnormal_male_reproductive1.34930409
60MP0002080_prenatal_lethality1.34447999
61MP0003136_yellow_coat_color1.31391070
62MP0002086_abnormal_extraembryonic_tissu1.30813665
63MP0002233_abnormal_nose_morphology1.29776697
64MP0004197_abnormal_fetal_growth/weight/1.28879455
65MP0000313_abnormal_cell_death1.28029657
66MP0003567_abnormal_fetal_cardiomyocyte1.27977965
67MP0004742_abnormal_vestibular_system1.27081494
68MP0000653_abnormal_sex_gland1.26967599
69MP0005367_renal/urinary_system_phenotyp1.26295671
70MP0000516_abnormal_urinary_system1.26295671
71MP0005646_abnormal_pituitary_gland1.24801895
72MP0002653_abnormal_ependyma_morphology1.22166680
73MP0000647_abnormal_sebaceous_gland1.21259584
74MP0008995_early_reproductive_senescence1.21171289
75MP0009745_abnormal_behavioral_response1.21019929
76MP0003011_delayed_dark_adaptation1.18943804
77MP0002396_abnormal_hematopoietic_system1.18781008
78MP0000049_abnormal_middle_ear1.18723877
79MP0000490_abnormal_crypts_of1.18547596
80MP0001119_abnormal_female_reproductive1.18157139
81MP0002734_abnormal_mechanical_nocicepti1.16039069
82MP0003635_abnormal_synaptic_transmissio1.15695798
83MP0005248_abnormal_Harderian_gland1.14850683
84MP0004147_increased_porphyrin_level1.13699565
85MP0002160_abnormal_reproductive_system1.13130191
86MP0003119_abnormal_digestive_system1.13052599
87MP0001986_abnormal_taste_sensitivity1.10371131
88MP0003950_abnormal_plasma_membrane1.10357614
89MP0002019_abnormal_tumor_incidence1.10257370
90MP0000427_abnormal_hair_cycle1.09611038
91MP0002572_abnormal_emotion/affect_behav1.08823203
92MP0002184_abnormal_innervation1.08582828
93MP0005391_vision/eye_phenotype1.08282561
94MP0005389_reproductive_system_phenotype1.07507791
95MP0005084_abnormal_gallbladder_morpholo1.05862454
96MP0002067_abnormal_sensory_capabilities1.04884506
97MP0003186_abnormal_redox_activity1.04620280
98MP0002557_abnormal_social/conspecific_i1.03477846
99MP0005645_abnormal_hypothalamus_physiol1.02083349
100MP0005408_hypopigmentation1.01892993
101MP0003937_abnormal_limbs/digits/tail_de1.00627036
102MP0002277_abnormal_respiratory_mucosa0.99948391
103MP0002752_abnormal_somatic_nervous0.99926027
104MP0004924_abnormal_behavior0.99632403
105MP0005386_behavior/neurological_phenoty0.99632403
106MP0004215_abnormal_myocardial_fiber0.98682550
107MP0003787_abnormal_imprinting0.96726536
108MP0002063_abnormal_learning/memory/cond0.95974300
109MP0002132_abnormal_respiratory_system0.94567261
110MP0003938_abnormal_ear_development0.94085340
111MP0009333_abnormal_splenocyte_physiolog0.94044676
112MP0001286_abnormal_eye_development0.91934371
113MP0002735_abnormal_chemical_nociception0.91297107
114MP0001919_abnormal_reproductive_system0.89569001
115MP0005395_other_phenotype0.88621113
116MP0004811_abnormal_neuron_physiology0.87067042
117MP0005187_abnormal_penis_morphology0.85003365
118MP0000955_abnormal_spinal_cord0.84823128
119MP0001177_atelectasis0.83798673
120MP0003763_abnormal_thymus_physiology0.82265172
121MP0002882_abnormal_neuron_morphology0.82161033
122MP0000372_irregular_coat_pigmentation0.80642594
123MP0004808_abnormal_hematopoietic_stem0.80392834
124MP0003861_abnormal_nervous_system0.80049767
125MP0001502_abnormal_circadian_rhythm0.79895827
126MP0000026_abnormal_inner_ear0.79673374
127MP0005195_abnormal_posterior_eye0.79405068
128MP0001188_hyperpigmentation0.79122638
129MP0005266_abnormal_metabolism0.78504969
130MP0002111_abnormal_tail_morphology0.77002678
131MP0003936_abnormal_reproductive_system0.76378400
132MP0000566_synostosis0.76364505
133MP0002152_abnormal_brain_morphology0.75848397
134MP0002064_seizures0.75282016
135MP0003698_abnormal_male_reproductive0.72057453
136MP0005075_abnormal_melanosome_morpholog0.71378726
137MP0003699_abnormal_female_reproductive0.71185948
138MP0000432_abnormal_head_morphology0.70124887
139MP0000703_abnormal_thymus_morphology0.69246345
140MP0005384_cellular_phenotype0.69115169
141MP0002877_abnormal_melanocyte_morpholog0.67875211
142MP0009703_decreased_birth_body0.66347303
143MP0005621_abnormal_cell_physiology0.65638379
144MP0001545_abnormal_hematopoietic_system0.65267697
145MP0005397_hematopoietic_system_phenotyp0.65267697
146MP0002638_abnormal_pupillary_reflex0.64589755
147MP0010030_abnormal_orbit_morphology0.63661561
148MP0009672_abnormal_birth_weight0.63236434
149MP0002009_preneoplasia0.60548075
150MP0002751_abnormal_autonomic_nervous0.59936634
151MP0002161_abnormal_fertility/fecundity0.59587522
152MP0006072_abnormal_retinal_apoptosis0.58572099
153MP0002092_abnormal_eye_morphology0.58527206
154MP0001849_ear_inflammation0.57955572
155MP0005076_abnormal_cell_differentiation0.57870161
156MP0002938_white_spotting0.57537059
157MP0002722_abnormal_immune_system0.57498581
158MP0000689_abnormal_spleen_morphology0.56891228
159MP0001915_intracranial_hemorrhage0.56368877
160MP0008260_abnormal_autophagy0.55079054
161MP0003755_abnormal_palate_morphology0.54101302
162MP0003221_abnormal_cardiomyocyte_apopto0.54061405
163MP0001186_pigmentation_phenotype0.53690462

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.95702242
2Breast hypoplasia (HP:0003187)4.65291993
3Abnormality of the labia minora (HP:0012880)4.22849344
4Medial flaring of the eyebrow (HP:0010747)3.95482312
5Chromsome breakage (HP:0040012)3.92485494
6Carpal bone hypoplasia (HP:0001498)3.89529002
7Gait imbalance (HP:0002141)3.88528179
8Congenital primary aphakia (HP:0007707)3.86043650
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.84112332
10Patellar aplasia (HP:0006443)3.75025128
11Supernumerary spleens (HP:0009799)3.71387633
12Nephrogenic diabetes insipidus (HP:0009806)3.53961412
13Aplasia/Hypoplasia of the patella (HP:0006498)3.46612364
14Absent radius (HP:0003974)3.45164182
15Degeneration of anterior horn cells (HP:0002398)3.34129608
16Abnormality of the anterior horn cell (HP:0006802)3.34129608
17True hermaphroditism (HP:0010459)3.28616514
18Absent forearm bone (HP:0003953)3.19882808
19Aplasia involving forearm bones (HP:0009822)3.19882808
20Impulsivity (HP:0100710)3.13682852
21Methylmalonic acidemia (HP:0002912)3.12912092
22Vaginal atresia (HP:0000148)3.08486591
23Pancreatic cysts (HP:0001737)3.07230376
24Hyperglycinemia (HP:0002154)3.06392453
25Genital tract atresia (HP:0001827)3.03456061
26Medulloblastoma (HP:0002885)3.02590116
27Meckel diverticulum (HP:0002245)3.00760054
28Agnosia (HP:0010524)3.00472493
29Abnormality of chromosome stability (HP:0003220)2.97859627
30Absent thumb (HP:0009777)2.92441588
31Abnormality of the ileum (HP:0001549)2.92154051
32Cerebral hypomyelination (HP:0006808)2.91744374
33Abnormality of the preputium (HP:0100587)2.91580205
34Ependymoma (HP:0002888)2.91477596
35Pancreatic fibrosis (HP:0100732)2.90261095
36Selective tooth agenesis (HP:0001592)2.83730069
37Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.81407938
38Rough bone trabeculation (HP:0100670)2.79454129
39Abnormality of midbrain morphology (HP:0002418)2.79073340
40Molar tooth sign on MRI (HP:0002419)2.79073340
41Colon cancer (HP:0003003)2.78207760
42Oral leukoplakia (HP:0002745)2.75428686
43Stenosis of the external auditory canal (HP:0000402)2.71348185
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.68983608
45Reticulocytopenia (HP:0001896)2.65897778
46Rectal fistula (HP:0100590)2.65293168
47Rectovaginal fistula (HP:0000143)2.65293168
48Abnormal lung lobation (HP:0002101)2.65249365
49Broad foot (HP:0001769)2.60493006
50Ectopic kidney (HP:0000086)2.60460749
51Poor coordination (HP:0002370)2.57148145
52Nephronophthisis (HP:0000090)2.56312889
53Rhabdomyosarcoma (HP:0002859)2.55558180
54Premature graying of hair (HP:0002216)2.49722127
55Horseshoe kidney (HP:0000085)2.48291931
56Focal motor seizures (HP:0011153)2.47320276
57Abnormality of serine family amino acid metabolism (HP:0010894)2.45742071
58Abnormality of glycine metabolism (HP:0010895)2.45742071
59Hyperglycinuria (HP:0003108)2.44045417
60Neoplasm of the oral cavity (HP:0100649)2.43876690
61Increased hepatocellular lipid droplets (HP:0006565)2.42077140
62Amyotrophic lateral sclerosis (HP:0007354)2.41130999
63Aplastic anemia (HP:0001915)2.41091111
64Retinal dysplasia (HP:0007973)2.40933593
65Abnormal trabecular bone morphology (HP:0100671)2.40729288
66Bone marrow hypocellularity (HP:0005528)2.38583835
67Small intestinal stenosis (HP:0012848)2.37439009
68Duodenal stenosis (HP:0100867)2.37439009
69Myelodysplasia (HP:0002863)2.36727745
70Lipid accumulation in hepatocytes (HP:0006561)2.36519278
71Atonic seizures (HP:0010819)2.35627381
72Abnormality of cells of the erythroid lineage (HP:0012130)2.33365278
73Intestinal fistula (HP:0100819)2.32497190
74Type II lissencephaly (HP:0007260)2.31276291
75Duplicated collecting system (HP:0000081)2.30060236
76Nephroblastoma (Wilms tumor) (HP:0002667)2.28915972
77Aplasia/Hypoplasia involving the musculature (HP:0001460)2.27749834
78Postaxial hand polydactyly (HP:0001162)2.27694811
79Abnormality of the metopic suture (HP:0005556)2.27467264
80Breast aplasia (HP:0100783)2.25420732
81Severe combined immunodeficiency (HP:0004430)2.25055718
82Decreased testicular size (HP:0008734)2.24904391
83Sloping forehead (HP:0000340)2.24694329
84Premature ovarian failure (HP:0008209)2.24570195
85Lissencephaly (HP:0001339)2.21476941
86Postaxial foot polydactyly (HP:0001830)2.20812976
87Specific learning disability (HP:0001328)2.20685291
88Acute necrotizing encephalopathy (HP:0006965)2.19113910
89Abnormal spermatogenesis (HP:0008669)2.19106921
90Methylmalonic aciduria (HP:0012120)2.18977322
91Aplasia/hypoplasia of the humerus (HP:0006507)2.18621850
92Hepatocellular necrosis (HP:0001404)2.18483262
93Shoulder girdle muscle weakness (HP:0003547)2.18348247
94Mitochondrial inheritance (HP:0001427)2.17768824
95Triphalangeal thumb (HP:0001199)2.16733338
96Abnormal number of erythroid precursors (HP:0012131)2.15115404
97Increased CSF lactate (HP:0002490)2.14521025
9811 pairs of ribs (HP:0000878)2.13654925
99Embryonal renal neoplasm (HP:0011794)2.13344631
100Cleft eyelid (HP:0000625)2.11955163
101Shawl scrotum (HP:0000049)2.11209932
102Failure to thrive in infancy (HP:0001531)2.11018390
103B lymphocytopenia (HP:0010976)2.10494299
104Intestinal atresia (HP:0011100)2.10448668
105Acute encephalopathy (HP:0006846)2.09414371
106Adrenal hypoplasia (HP:0000835)2.07923718
107Abnormality of the renal medulla (HP:0100957)2.07466669
108Aplasia/Hypoplasia of the tongue (HP:0010295)2.07464303
109Abnormal respiratory motile cilium morphology (HP:0005938)2.07066151
110Abnormal respiratory epithelium morphology (HP:0012253)2.07066151
111Thyroiditis (HP:0100646)2.07055653
112Type 2 muscle fiber atrophy (HP:0003554)2.07019925
113Irregular epiphyses (HP:0010582)2.06410792
114Rimmed vacuoles (HP:0003805)2.05143689
115Abnormality of the duodenum (HP:0002246)2.04541684
116Volvulus (HP:0002580)2.03964524
1173-Methylglutaconic aciduria (HP:0003535)2.03817221
118Aplasia/Hypoplasia of the breasts (HP:0010311)2.03622576
119Cortical dysplasia (HP:0002539)2.03247751
120Aplasia/Hypoplasia of the sternum (HP:0006714)2.03151186
121Neoplasm of the pancreas (HP:0002894)2.03150015
122Short thumb (HP:0009778)2.02979139
123Rib fusion (HP:0000902)2.02795993
124Polyphagia (HP:0002591)2.00987936
125Progressive macrocephaly (HP:0004481)2.00899391
126Cellular immunodeficiency (HP:0005374)1.99173918
127Abolished electroretinogram (ERG) (HP:0000550)1.99086240
128Exercise-induced muscle cramps (HP:0003710)1.97948595
129Abnormality of the renal collecting system (HP:0004742)1.97437115
130Hepatic necrosis (HP:0002605)1.96690454
131Abnormal biliary tract physiology (HP:0012439)1.96637622
132Bile duct proliferation (HP:0001408)1.96637622
133Abnormal number of incisors (HP:0011064)1.96500116
134Tubulointerstitial nephritis (HP:0001970)1.96490648
135Abnormal mitochondria in muscle tissue (HP:0008316)1.94740401
136Vaginal fistula (HP:0004320)1.94448781
137Hypoplasia of the radius (HP:0002984)1.94306343
138Secondary amenorrhea (HP:0000869)1.94298836
139Prominent metopic ridge (HP:0005487)1.93538029
140Tracheoesophageal fistula (HP:0002575)1.92998186
141Abnormality of the vitamin B12 metabolism (HP:0004341)1.88936816
142Increased serum pyruvate (HP:0003542)1.88367939
143Muscle fiber atrophy (HP:0100295)1.88120693
144Abnormal ciliary motility (HP:0012262)1.87626180
145Renal cortical cysts (HP:0000803)1.87438867
146Broad-based gait (HP:0002136)1.85718491
147Aplasia/Hypoplasia of the lens (HP:0008063)1.85120597
148CNS hypomyelination (HP:0003429)1.84567072
149Anal stenosis (HP:0002025)1.83695341
150Dynein arm defect of respiratory motile cilia (HP:0012255)1.83653527
151Absent/shortened dynein arms (HP:0200106)1.83653527
152Chronic hepatic failure (HP:0100626)1.83638670
153Amaurosis fugax (HP:0100576)1.83381003
154Abnormality of B cell number (HP:0010975)1.83273223
155Sclerocornea (HP:0000647)1.82636764
156Drooling (HP:0002307)1.82483241
157Clubbing of toes (HP:0100760)1.81832629
158Atresia of the external auditory canal (HP:0000413)1.81525907
159Febrile seizures (HP:0002373)1.81285930
160Thyroid-stimulating hormone excess (HP:0002925)1.81181078
161Postnatal microcephaly (HP:0005484)1.80861573
162Anencephaly (HP:0002323)1.80418651
163Renal Fanconi syndrome (HP:0001994)1.79988526
164Panhypogammaglobulinemia (HP:0003139)1.79843451
165Oligodactyly (hands) (HP:0001180)1.79439227
166Progressive inability to walk (HP:0002505)1.78650861
167Gastrointestinal atresia (HP:0002589)1.77713836
168Increased serum lactate (HP:0002151)1.77519445
169Facial hemangioma (HP:0000329)1.76957260
170Bifid tongue (HP:0010297)1.76679530
171Asplenia (HP:0001746)1.76392058
172Gonadotropin excess (HP:0000837)1.75350641
173Macrocytic anemia (HP:0001972)1.75086687
174Fused cervical vertebrae (HP:0002949)1.74561530
175Narrow forehead (HP:0000341)1.74058816
176Glioma (HP:0009733)1.74041859
177Optic nerve hypoplasia (HP:0000609)1.73931507
178Lymphoma (HP:0002665)1.73493418
179Abnormality of vitamin B metabolism (HP:0004340)1.73285996
180Oligodactyly (HP:0012165)1.73203531
181Preaxial hand polydactyly (HP:0001177)1.73092323
182Abnormality of the hip-girdle musculature (HP:0001445)1.72723151
183Abnormality of the musculature of the pelvis (HP:0001469)1.72723151
184Hemiparesis (HP:0001269)1.72408552
185Abnormality of the renal cortex (HP:0011035)1.72215043
186Astigmatism (HP:0000483)1.71764756
187Type I transferrin isoform profile (HP:0003642)1.71641474
188Abdominal situs inversus (HP:0003363)1.71191567
189Abnormality of abdominal situs (HP:0011620)1.71191567
190Atrophy/Degeneration involving motor neurons (HP:0007373)1.70980712
191Tongue fasciculations (HP:0001308)1.70577449
192Missing ribs (HP:0000921)1.69845160
193Short humerus (HP:0005792)1.69583184
194Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69225435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.91235535
2BUB13.80513410
3BRD43.78866957
4MAP4K23.55074574
5CDC73.35451077
6TRIM283.32087215
7SRPK13.17485630
8EIF2AK12.83785339
9PLK42.77743572
10MKNK22.77060930
11CDK192.70069951
12MKNK12.61737933
13MAP3K42.50917472
14TTK2.39825378
15CASK2.31521988
16MAP2K72.27625467
17TSSK62.26955953
18PLK12.21562382
19BRSK22.16484988
20PLK32.12472957
21EIF2AK32.09066203
22VRK12.08170821
23CDK121.99757046
24EPHA41.85386841
25ERBB31.85188446
26EPHA21.84957034
27STK38L1.84636779
28ACVR1B1.80410497
29NEK21.79758112
30MARK11.75846109
31BCKDK1.71528214
32NUAK11.69596408
33ZAK1.64734848
34CSNK1G31.60714302
35CDK71.60144813
36DYRK31.59724657
37CSNK1G21.57720403
38MAPK131.56606248
39FRK1.56373701
40AKT31.52585230
41CHEK21.51511951
42NME21.51442960
43CSNK1G11.48829344
44ATR1.43679175
45RPS6KB21.43564893
46AURKB1.41658005
47SIK31.40204112
48STK161.38733158
49CSNK1A1L1.36454094
50NEK11.30622348
51TLK11.29481306
52PLK21.27125318
53PASK1.26594348
54PBK1.22832023
55VRK21.18417646
56AURKA1.16686659
57CHEK11.16115935
58CAMKK21.13649554
59TESK21.11864506
60EIF2AK21.11210019
61IRAK11.08222241
62STK41.00104526
63RPS6KA40.99357485
64PIM10.99322248
65DYRK1B0.97647022
66MST40.97067468
67PNCK0.96425870
68TNIK0.94816112
69MAP3K80.94672376
70BRAF0.94116207
71EPHA30.93963682
72ATM0.93396686
73PAK30.93365500
74DYRK20.92368296
75MELK0.91182533
76CDK80.88046368
77PRKCE0.86913485
78BRSK10.84531459
79CDK20.83714049
80STK100.83400015
81LATS20.83155512
82FGFR20.82349009
83ADRBK20.81282638
84DYRK1A0.78319424
85NEK60.77840986
86MINK10.77283889
87KSR10.74956971
88RPS6KA50.73522906
89CDK40.69658050
90GRK10.68325144
91CSNK2A10.67828370
92ALK0.66640611
93CSNK2A20.66295820
94FLT30.64261907
95NTRK20.63540499
96PRKCG0.62819252
97UHMK10.62816343
98CDK10.61915869
99MUSK0.61555666
100IRAK30.61223276
101OBSCN0.61011915
102TGFBR10.60259169
103YES10.60241725
104PDK20.60205730
105NLK0.60001769
106MAP3K50.58939255
107MAP2K40.57140236
108BMPR20.51142173
109STK30.50740031
110STK240.49947952
111CDK90.49618544
112CAMK2A0.49544213
113PRKCI0.49239255
114CHUK0.48313259
115IRAK40.47089239
116IKBKB0.46656103
117TXK0.45694516
118WNK30.45097620
119INSRR0.44470695
120OXSR10.44281819
121NEK90.42254075
122ERBB40.42211810
123LIMK10.42089788
124MAP3K140.42013915
125CDK30.41981474
126PKN10.41094123
127BCR0.40949059
128MARK30.39674677
129PAK40.39546282
130RPS6KB10.39439655
131IKBKE0.38118855
132PAK10.37468862
133MAP3K60.36142404
134SIK20.35980718
135LATS10.35388152
136CSNK1A10.34948652
137CCNB10.33496014
138IRAK20.33007283
139CSNK1E0.32406407
140PRKACA0.32398555
141TEC0.31421665
142FER0.31263568
143PINK10.31169037
144PHKG20.30581202
145MAP3K130.29406814
146MAPK140.29211424
147CSNK1D0.28655681
148TESK10.28388871
149MAP3K30.28041184
150TIE10.27601942
151CDK60.27078819
152AKT10.23353388
153BMPR1B0.22971025
154PRKDC0.22820455

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.21650143
2RNA polymerase_Homo sapiens_hsa030204.20867313
3DNA replication_Homo sapiens_hsa030304.09071565
4Mismatch repair_Homo sapiens_hsa034303.99986948
5Proteasome_Homo sapiens_hsa030503.44620133
6Spliceosome_Homo sapiens_hsa030403.32406398
7RNA transport_Homo sapiens_hsa030133.26529950
8Homologous recombination_Homo sapiens_hsa034403.10068099
9Ribosome_Homo sapiens_hsa030102.88193966
10Propanoate metabolism_Homo sapiens_hsa006402.84754627
11Base excision repair_Homo sapiens_hsa034102.76793594
12Nucleotide excision repair_Homo sapiens_hsa034202.74598671
13Cell cycle_Homo sapiens_hsa041102.71559881
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.61381528
15* Basal transcription factors_Homo sapiens_hsa030222.59761514
16Fanconi anemia pathway_Homo sapiens_hsa034602.55130495
17Pyrimidine metabolism_Homo sapiens_hsa002402.47823573
18RNA degradation_Homo sapiens_hsa030182.32506634
19Non-homologous end-joining_Homo sapiens_hsa034502.28055490
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.25825336
21One carbon pool by folate_Homo sapiens_hsa006702.24878230
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20743209
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.15591158
24Fatty acid elongation_Homo sapiens_hsa000622.07266727
25mRNA surveillance pathway_Homo sapiens_hsa030151.87623055
26Butanoate metabolism_Homo sapiens_hsa006501.74640147
27p53 signaling pathway_Homo sapiens_hsa041151.66630137
28Nicotine addiction_Homo sapiens_hsa050331.61925945
29Phototransduction_Homo sapiens_hsa047441.54731496
30Nitrogen metabolism_Homo sapiens_hsa009101.48744563
31Purine metabolism_Homo sapiens_hsa002301.47295780
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38262752
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33297501
34Taste transduction_Homo sapiens_hsa047421.31726763
35Peroxisome_Homo sapiens_hsa041461.31174234
36Epstein-Barr virus infection_Homo sapiens_hsa051691.30255765
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25941713
38Circadian rhythm_Homo sapiens_hsa047101.19926461
39GABAergic synapse_Homo sapiens_hsa047271.18486344
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15567810
41Alzheimers disease_Homo sapiens_hsa050101.11526552
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09798734
43Cardiac muscle contraction_Homo sapiens_hsa042601.07931374
44Fatty acid metabolism_Homo sapiens_hsa012121.04314221
45Herpes simplex infection_Homo sapiens_hsa051681.00261557
46Collecting duct acid secretion_Homo sapiens_hsa049660.99157262
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99087759
48Protein export_Homo sapiens_hsa030600.98436687
49Oocyte meiosis_Homo sapiens_hsa041140.95409646
50Vitamin B6 metabolism_Homo sapiens_hsa007500.93228503
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90018613
52Systemic lupus erythematosus_Homo sapiens_hsa053220.88659469
53Olfactory transduction_Homo sapiens_hsa047400.85872591
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85627244
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84580522
56Huntingtons disease_Homo sapiens_hsa050160.82910675
57Long-term depression_Homo sapiens_hsa047300.81755323
58Folate biosynthesis_Homo sapiens_hsa007900.81190341
59Carbon metabolism_Homo sapiens_hsa012000.80430449
60Morphine addiction_Homo sapiens_hsa050320.78419637
61Antigen processing and presentation_Homo sapiens_hsa046120.77651388
62beta-Alanine metabolism_Homo sapiens_hsa004100.76520934
63Dopaminergic synapse_Homo sapiens_hsa047280.75750047
64Viral carcinogenesis_Homo sapiens_hsa052030.75296560
65Pyruvate metabolism_Homo sapiens_hsa006200.74862316
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70433263
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68266380
68Thyroid cancer_Homo sapiens_hsa052160.67821715
69TGF-beta signaling pathway_Homo sapiens_hsa043500.67059845
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66911844
71Circadian entrainment_Homo sapiens_hsa047130.66542048
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61592908
73Arachidonic acid metabolism_Homo sapiens_hsa005900.61262712
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60965182
75HTLV-I infection_Homo sapiens_hsa051660.58761934
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57708951
77MicroRNAs in cancer_Homo sapiens_hsa052060.57690503
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57595009
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57485715
80Regulation of autophagy_Homo sapiens_hsa041400.57400904
81Legionellosis_Homo sapiens_hsa051340.56837898
82Glutamatergic synapse_Homo sapiens_hsa047240.55873658
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.55420121
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.50690843
85Linoleic acid metabolism_Homo sapiens_hsa005910.50635616
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.50601479
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49603136
88Serotonergic synapse_Homo sapiens_hsa047260.48802704
89Selenocompound metabolism_Homo sapiens_hsa004500.48692324
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48656844
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.47609767
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.47519949
93Hippo signaling pathway_Homo sapiens_hsa043900.45970500
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45057518
95Glutathione metabolism_Homo sapiens_hsa004800.43723214
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41934689
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41865686
98Amphetamine addiction_Homo sapiens_hsa050310.41701025
99N-Glycan biosynthesis_Homo sapiens_hsa005100.41491315
100Pentose phosphate pathway_Homo sapiens_hsa000300.41261658
101Synaptic vesicle cycle_Homo sapiens_hsa047210.40199584
102Parkinsons disease_Homo sapiens_hsa050120.39738222
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39717240
104Graft-versus-host disease_Homo sapiens_hsa053320.39376039
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.37319796
106Basal cell carcinoma_Homo sapiens_hsa052170.37146416
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35309047
108Notch signaling pathway_Homo sapiens_hsa043300.34876006
109Small cell lung cancer_Homo sapiens_hsa052220.34522606
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34452675
111Allograft rejection_Homo sapiens_hsa053300.34163412
112Cocaine addiction_Homo sapiens_hsa050300.32653768
113Fatty acid degradation_Homo sapiens_hsa000710.31736362
114Apoptosis_Homo sapiens_hsa042100.31163041
115Insulin secretion_Homo sapiens_hsa049110.30967514
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30548207
117Biosynthesis of amino acids_Homo sapiens_hsa012300.30493980
118Fructose and mannose metabolism_Homo sapiens_hsa000510.29959096
119Axon guidance_Homo sapiens_hsa043600.29866296
120Oxidative phosphorylation_Homo sapiens_hsa001900.29799570
121Prostate cancer_Homo sapiens_hsa052150.29091424
122Ether lipid metabolism_Homo sapiens_hsa005650.29040483
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28875019
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28524967
125Measles_Homo sapiens_hsa051620.27227282
126Alcoholism_Homo sapiens_hsa050340.27011179
127Asthma_Homo sapiens_hsa053100.26910058
128Caffeine metabolism_Homo sapiens_hsa002320.26776302
129Autoimmune thyroid disease_Homo sapiens_hsa053200.26025084
130Colorectal cancer_Homo sapiens_hsa052100.24239971
131Metabolic pathways_Homo sapiens_hsa011000.23898759
132Pathways in cancer_Homo sapiens_hsa052000.23721660
133Primary immunodeficiency_Homo sapiens_hsa053400.22016865
134Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22009091
135Influenza A_Homo sapiens_hsa051640.21456586
136Hedgehog signaling pathway_Homo sapiens_hsa043400.20627763
137Wnt signaling pathway_Homo sapiens_hsa043100.18830409
138Tight junction_Homo sapiens_hsa045300.18205337
139Intestinal immune network for IgA production_Homo sapiens_hsa046720.18019937
140Hematopoietic cell lineage_Homo sapiens_hsa046400.17953659
141Hepatitis B_Homo sapiens_hsa051610.17430200
142Type I diabetes mellitus_Homo sapiens_hsa049400.16831000
143FoxO signaling pathway_Homo sapiens_hsa040680.16773799
144Sphingolipid metabolism_Homo sapiens_hsa006000.14320449
145Galactose metabolism_Homo sapiens_hsa000520.13196637
146RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13092450
147HIF-1 signaling pathway_Homo sapiens_hsa040660.11874820
148Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11030697
149Steroid biosynthesis_Homo sapiens_hsa001000.10683185

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