TAF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes an integral subunit of TFIID associated with all transcriptionally competent forms of that complex. This subunit interacts strongly with two TFIID subunits that show similarity to histones H3 and H4, and it may participate in forming a nucleosome-like core in the TFIID complex. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.67405528
2protein localization to kinetochore (GO:0034501)5.49101063
3protein localization to chromosome, centromeric region (GO:0071459)5.37506011
4nuclear pore complex assembly (GO:0051292)5.07739188
5mitotic chromosome condensation (GO:0007076)5.00702521
6nuclear pore organization (GO:0006999)4.95762890
7kinetochore organization (GO:0051383)4.93537642
8metaphase plate congression (GO:0051310)4.87188211
9mitotic sister chromatid segregation (GO:0000070)4.76107539
10kinetochore assembly (GO:0051382)4.50124136
11attachment of spindle microtubules to kinetochore (GO:0008608)4.48361740
12meiotic chromosome segregation (GO:0045132)4.44093557
13synapsis (GO:0007129)4.43262035
14DNA replication checkpoint (GO:0000076)4.40603888
15sister chromatid segregation (GO:0000819)4.39228672
16chromatin remodeling at centromere (GO:0031055)4.35543116
17establishment of chromosome localization (GO:0051303)4.32405132
18CENP-A containing nucleosome assembly (GO:0034080)4.27212527
19DNA unwinding involved in DNA replication (GO:0006268)4.24769062
20protein K6-linked ubiquitination (GO:0085020)4.22187298
21mitotic nuclear envelope disassembly (GO:0007077)4.18704423
22regulation of centriole replication (GO:0046599)4.12602828
23mitotic sister chromatid cohesion (GO:0007064)4.07995713
24positive regulation of chromosome segregation (GO:0051984)4.05287573
25regulation of telomere maintenance via telomerase (GO:0032210)4.01856461
26DNA topological change (GO:0006265)4.00326645
27positive regulation of mitotic sister chromatid separation (GO:1901970)3.99785657
28positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.99785657
29positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.99785657
30regulation of spindle organization (GO:0090224)3.97665523
31chromosome organization involved in meiosis (GO:0070192)3.97546794
32regulation of meiosis I (GO:0060631)3.96210635
33microtubule depolymerization (GO:0007019)3.95134677
34protein localization to chromosome (GO:0034502)3.95105966
35pore complex assembly (GO:0046931)3.94795871
36DNA ligation (GO:0006266)3.94528429
37DNA replication-independent nucleosome assembly (GO:0006336)3.93967643
38DNA replication-independent nucleosome organization (GO:0034724)3.93967643
39membrane disassembly (GO:0030397)3.93410239
40nuclear envelope disassembly (GO:0051081)3.93410239
41regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.92531848
42histone exchange (GO:0043486)3.84116750
43DNA replication initiation (GO:0006270)3.83055844
44regulation of double-strand break repair via homologous recombination (GO:0010569)3.66903427
45DNA replication-dependent nucleosome assembly (GO:0006335)3.66175367
46DNA replication-dependent nucleosome organization (GO:0034723)3.66175367
47chromosome segregation (GO:0007059)3.65181372
48establishment of integrated proviral latency (GO:0075713)3.64005845
49regulation of DNA endoreduplication (GO:0032875)3.60574535
50regulation of sister chromatid cohesion (GO:0007063)3.60046684
51DNA strand elongation involved in DNA replication (GO:0006271)3.59428492
52regulation of chromosome segregation (GO:0051983)3.55229286
53chromatin assembly or disassembly (GO:0006333)3.52090660
54regulation of histone H3-K9 methylation (GO:0051570)3.52031992
55regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.50623415
56spindle checkpoint (GO:0031577)3.45430564
57regulation of mitotic spindle organization (GO:0060236)3.45401807
58histone H2A acetylation (GO:0043968)3.44979292
59DNA strand elongation (GO:0022616)3.42139432
60histone H2A monoubiquitination (GO:0035518)3.41660080
61regulation of double-strand break repair (GO:2000779)3.41586722
62regulation of mitotic metaphase/anaphase transition (GO:0030071)3.37949301
63regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.36532397
64folic acid-containing compound biosynthetic process (GO:0009396)3.35334169
65negative regulation of histone methylation (GO:0031061)3.35299308
66pre-miRNA processing (GO:0031054)3.33872574
67regulation of RNA export from nucleus (GO:0046831)3.32523208
68mitotic recombination (GO:0006312)3.32115795
69DNA duplex unwinding (GO:0032508)3.30593433
70DNA geometric change (GO:0032392)3.28793894
71meiotic cell cycle process (GO:1903046)3.25952256
72regulation of mitotic sister chromatid separation (GO:0010965)3.25285849
73regulation of mitotic sister chromatid segregation (GO:0033047)3.25285849
74regulation of sister chromatid segregation (GO:0033045)3.25285849
75regulation of exit from mitosis (GO:0007096)3.25006709
76paraxial mesoderm development (GO:0048339)3.24214731
77negative regulation of chromosome segregation (GO:0051985)3.24013052
78non-recombinational repair (GO:0000726)3.22153207
79double-strand break repair via nonhomologous end joining (GO:0006303)3.22153207
80DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.21660322
81ATP-dependent chromatin remodeling (GO:0043044)3.21005028
82telomere maintenance via semi-conservative replication (GO:0032201)3.20751091
83telomere maintenance via recombination (GO:0000722)3.19426770
84negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.19219633
85negative regulation of sister chromatid segregation (GO:0033046)3.19219633
86negative regulation of mitotic sister chromatid separation (GO:2000816)3.19219633
87negative regulation of mitotic sister chromatid segregation (GO:0033048)3.19219633
88negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.17936865
89nucleotide-excision repair, DNA gap filling (GO:0006297)3.16058081
90DNA damage response, signal transduction resulting in transcription (GO:0042772)3.14661320
91sister chromatid cohesion (GO:0007062)3.14038027
92chromosome condensation (GO:0030261)3.13960411
93spindle assembly checkpoint (GO:0071173)3.13657088
94mitotic spindle checkpoint (GO:0071174)3.12595329
95centriole replication (GO:0007099)3.11810803
96piRNA metabolic process (GO:0034587)3.10734467
97telomere maintenance via telomere lengthening (GO:0010833)3.09917175
98heterochromatin organization (GO:0070828)3.09670934
99inner cell mass cell proliferation (GO:0001833)3.08991593
100V(D)J recombination (GO:0033151)3.08629899
101mitotic spindle assembly checkpoint (GO:0007094)3.07273973
102DNA synthesis involved in DNA repair (GO:0000731)3.06582752
103DNA double-strand break processing (GO:0000729)3.05453335
104resolution of meiotic recombination intermediates (GO:0000712)3.05407572
105neural tube formation (GO:0001841)3.04385167
106regulation of protein polyubiquitination (GO:1902914)3.04249868
107nuclear envelope organization (GO:0006998)3.03549502
108ribosome biogenesis (GO:0042254)3.03403293
109maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.02759491
110negative regulation of DNA repair (GO:0045738)3.02122406
111somatic hypermutation of immunoglobulin genes (GO:0016446)3.01499955
112somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01499955
113regulation of centrosome duplication (GO:0010824)3.00984650
114DNA conformation change (GO:0071103)3.00536124
115negative regulation of DNA-dependent DNA replication (GO:2000104)2.98766640
116regulation of DNA methylation (GO:0044030)2.98765960
117regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98621643
118regulation of centrosome cycle (GO:0046605)2.94974737
119regulation of nuclear cell cycle DNA replication (GO:0033262)2.94938428
120DNA packaging (GO:0006323)2.94563171
121gene silencing by RNA (GO:0031047)2.93183493
122reciprocal meiotic recombination (GO:0007131)2.93102020
123reciprocal DNA recombination (GO:0035825)2.93102020
124maturation of SSU-rRNA (GO:0030490)2.92480418
125chromosome organization (GO:0051276)2.92110999
126chromatin assembly (GO:0031497)2.91923980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.96889488
2* FOXM1_23109430_ChIP-Seq_U2OS_Human6.05474208
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.58157967
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.06543147
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.76777472
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.88489919
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.88186961
8AR_21909140_ChIP-Seq_LNCAP_Human2.71443115
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.67553376
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.60496121
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53394987
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.48296206
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.29775776
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.24215233
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.22409274
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20732928
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.19233978
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13193939
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.11895532
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10421911
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.09228251
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09141328
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03478814
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02746212
25* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.01760971
26XRN2_22483619_ChIP-Seq_HELA_Human1.92903372
27* ETS1_20019798_ChIP-Seq_JURKAT_Human1.79955576
28VDR_23849224_ChIP-Seq_CD4+_Human1.79477232
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.77544391
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75558321
31MYC_22102868_ChIP-Seq_BL_Human1.73509529
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71565725
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71565725
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71565725
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70908411
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65726465
37ZNF274_21170338_ChIP-Seq_K562_Hela1.65578780
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61854694
39TTF2_22483619_ChIP-Seq_HELA_Human1.61251182
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60267141
41FOXP3_21729870_ChIP-Seq_TREG_Human1.59779777
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55828461
43* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54899695
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49336207
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46990635
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43430571
47DCP1A_22483619_ChIP-Seq_HELA_Human1.42662612
48ELK1_19687146_ChIP-ChIP_HELA_Human1.41875892
49KDM5A_27292631_Chip-Seq_BREAST_Human1.40958994
50GABP_19822575_ChIP-Seq_HepG2_Human1.38269930
51CIITA_25753668_ChIP-Seq_RAJI_Human1.37127317
52EWS_26573619_Chip-Seq_HEK293_Human1.37066247
53* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36528354
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36003488
55* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35723492
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33209128
57* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31209164
58* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29609743
59* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24981837
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24247329
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22309588
62MYC_18940864_ChIP-ChIP_HL60_Human1.20353303
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18478607
64* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17019005
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14368223
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13711097
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13590070
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12649149
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11892621
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11332869
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.09031557
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08390009
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08252228
74TCF3_18692474_ChIP-Seq_MESCs_Mouse1.08006994
75* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07600643
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04780405
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04519536
78* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03633985
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02736522
80SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02531763
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01629587
82NANOG_21062744_ChIP-ChIP_HESCs_Human1.01497466
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01483078
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00467461
85TFEB_21752829_ChIP-Seq_HELA_Human0.98378986
86NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95528698
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94989875
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94799500
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94667964
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94080116
91NANOG_16153702_ChIP-ChIP_HESCs_Human0.93528851
92SOX2_16153702_ChIP-ChIP_HESCs_Human0.93341815
93FUS_26573619_Chip-Seq_HEK293_Human0.90269622
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88761603
95NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87657573
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87241785
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86267752
98ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86232354
99ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85325801
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.85255264
101PKCTHETA_26484144_Chip-Seq_BREAST_Human0.84610733
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84436007
103* YY1_21170310_ChIP-Seq_MESCs_Mouse0.83540488
104CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82623272
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81066717
106SRF_21415370_ChIP-Seq_HL-1_Mouse0.80690266
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80265719
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.78216971
109NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77644764
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.77551889
111CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.76668559
112VDR_21846776_ChIP-Seq_THP-1_Human0.76268050
113GATA1_26923725_Chip-Seq_HPCs_Mouse0.75086760
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74893751
115IGF1R_20145208_ChIP-Seq_DFB_Human0.73618133
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72987961
117IRF1_19129219_ChIP-ChIP_H3396_Human0.72894463
118POU3F2_20337985_ChIP-ChIP_501MEL_Human0.72617229
119TAF15_26573619_Chip-Seq_HEK293_Human0.70774776
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.70520752
121* CHD1_26751641_Chip-Seq_LNCaP_Human0.62674115

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.23457739
2MP0010094_abnormal_chromosome_stability4.60470986
3MP0003111_abnormal_nucleus_morphology4.42602841
4MP0008057_abnormal_DNA_replication4.29073337
5MP0004957_abnormal_blastocyst_morpholog4.16548416
6MP0003077_abnormal_cell_cycle3.97112170
7MP0008877_abnormal_DNA_methylation3.03007504
8MP0002653_abnormal_ependyma_morphology2.96006315
9MP0008058_abnormal_DNA_repair2.94691824
10MP0002009_preneoplasia2.79641063
11MP0008007_abnormal_cellular_replicative2.63928141
12MP0003123_paternal_imprinting2.51573514
13MP0010307_abnormal_tumor_latency2.51268543
14MP0001730_embryonic_growth_arrest2.42217229
15MP0000350_abnormal_cell_proliferation2.40768249
16MP0010352_gastrointestinal_tract_polyps2.32425318
17MP0008932_abnormal_embryonic_tissue2.28421248
18MP0003718_maternal_effect2.16297012
19MP0001672_abnormal_embryogenesis/_devel1.96167963
20MP0005380_embryogenesis_phenotype1.96167963
21MP0003121_genomic_imprinting1.90096351
22MP0003191_abnormal_cellular_cholesterol1.89126231
23MP0001697_abnormal_embryo_size1.85815403
24MP0002396_abnormal_hematopoietic_system1.81039801
25MP0009697_abnormal_copulation1.80759432
26MP0002638_abnormal_pupillary_reflex1.77599515
27MP0002085_abnormal_embryonic_tissue1.76564386
28MP0003221_abnormal_cardiomyocyte_apopto1.74558697
29MP0006292_abnormal_olfactory_placode1.72830394
30MP0003890_abnormal_embryonic-extraembry1.72277054
31MP0003984_embryonic_growth_retardation1.70060778
32MP0008789_abnormal_olfactory_epithelium1.68750476
33MP0003786_premature_aging1.68666870
34MP0002084_abnormal_developmental_patter1.68657271
35MP0002088_abnormal_embryonic_growth/wei1.66605870
36MP0002210_abnormal_sex_determination1.63321575
37MP0002086_abnormal_extraembryonic_tissu1.63271920
38MP0005076_abnormal_cell_differentiation1.58823655
39MP0001929_abnormal_gametogenesis1.53682090
40MP0004197_abnormal_fetal_growth/weight/1.51172873
41MP0002080_prenatal_lethality1.47223549
42MP0004808_abnormal_hematopoietic_stem1.42142356
43MP0000313_abnormal_cell_death1.42104644
44MP0001293_anophthalmia1.40829414
45MP0003787_abnormal_imprinting1.38333458
46MP0005499_abnormal_olfactory_system1.38268414
47MP0005394_taste/olfaction_phenotype1.38268414
48MP0000653_abnormal_sex_gland1.38138799
49MP0001145_abnormal_male_reproductive1.37197766
50MP0000490_abnormal_crypts_of1.36756795
51MP0006035_abnormal_mitochondrial_morpho1.34795186
52MP0002019_abnormal_tumor_incidence1.33424257
53MP0003937_abnormal_limbs/digits/tail_de1.30037915
54MP0000372_irregular_coat_pigmentation1.29903975
55MP0009672_abnormal_birth_weight1.22424251
56MP0001119_abnormal_female_reproductive1.21575636
57MP0003119_abnormal_digestive_system1.18189430
58MP0005397_hematopoietic_system_phenotyp1.17685613
59MP0001545_abnormal_hematopoietic_system1.17685613
60MP0003315_abnormal_perineum_morphology1.17194874
61MP0002751_abnormal_autonomic_nervous1.16652233
62MP0004264_abnormal_extraembryonic_tissu1.13695358
63MP0001188_hyperpigmentation1.11465536
64MP0001915_intracranial_hemorrhage1.06856512
65MP0003567_abnormal_fetal_cardiomyocyte1.05810540
66MP0001764_abnormal_homeostasis1.05452912
67MP0000049_abnormal_middle_ear1.03462922
68MP0002102_abnormal_ear_morphology1.01440272
69MP0009703_decreased_birth_body1.01408290
70MP0003699_abnormal_female_reproductive1.01159349
71MP0000631_abnormal_neuroendocrine_gland1.00634458
72MP0005647_abnormal_sex_gland0.91749417
73MP0002234_abnormal_pharynx_morphology0.89443044
74MP0000703_abnormal_thymus_morphology0.87738830
75MP0005367_renal/urinary_system_phenotyp0.86881262
76MP0000516_abnormal_urinary_system0.86881262
77MP0002092_abnormal_eye_morphology0.85942101
78MP0003705_abnormal_hypodermis_morpholog0.84845827
79MP0003385_abnormal_body_wall0.84468893
80MP0004782_abnormal_surfactant_physiolog0.83709371
81MP0002233_abnormal_nose_morphology0.83534186
82MP0001286_abnormal_eye_development0.83324779
83MP0001849_ear_inflammation0.82609330
84MP0005621_abnormal_cell_physiology0.82570018
85MP0000432_abnormal_head_morphology0.82412835
86MP0003698_abnormal_male_reproductive0.82300168
87MP0002796_impaired_skin_barrier0.82255139
88MP0003763_abnormal_thymus_physiology0.81752022
89MP0002161_abnormal_fertility/fecundity0.81441394
90MP0002398_abnormal_bone_marrow0.80840111
91MP0000537_abnormal_urethra_morphology0.80319995
92MP0005384_cellular_phenotype0.79697061
93MP0002938_white_spotting0.79234749
94MP0002111_abnormal_tail_morphology0.79218315
95MP0009053_abnormal_anal_canal0.77961644
96MP0003935_abnormal_craniofacial_develop0.77891494
97MP0010234_abnormal_vibrissa_follicle0.75470222
98MP0000733_abnormal_muscle_development0.74823062
99MP0010030_abnormal_orbit_morphology0.73369429
100MP0002722_abnormal_immune_system0.72381445
101MP0003880_abnormal_central_pattern0.72050188
102MP0004233_abnormal_muscle_weight0.71967026
103MP0003755_abnormal_palate_morphology0.70701850
104MP0008995_early_reproductive_senescence0.70091376
105MP0000358_abnormal_cell_content/0.69031536
106MP0002160_abnormal_reproductive_system0.68879713
107MP0002006_tumorigenesis0.68355344
108MP0000689_abnormal_spleen_morphology0.68085740
109MP0003861_abnormal_nervous_system0.65704729
110MP0004134_abnormal_chest_morphology0.65412091
111MP0002925_abnormal_cardiovascular_devel0.65107807
112MP0000647_abnormal_sebaceous_gland0.64822276
113MP0001177_atelectasis0.64087690
114MP0002697_abnormal_eye_size0.63496912
115MP0009333_abnormal_splenocyte_physiolog0.61206122
116MP0006036_abnormal_mitochondrial_physio0.60921023
117MP0005391_vision/eye_phenotype0.60636943
118MP0005395_other_phenotype0.60257536
119MP0005501_abnormal_skin_physiology0.59600628
120MP0003115_abnormal_respiratory_system0.59132269
121MP0000428_abnormal_craniofacial_morphol0.57924089
122MP0005253_abnormal_eye_physiology0.57223150
123MP0001340_abnormal_eyelid_morphology0.55904772
124MP0003941_abnormal_skin_development0.55699393
125MP0005389_reproductive_system_phenotype0.55573615
126MP0000477_abnormal_intestine_morphology0.54789436
127MP0002114_abnormal_axial_skeleton0.53481591
128MP0004185_abnormal_adipocyte_glucose0.51861497
129MP0002429_abnormal_blood_cell0.51303383
130MP0003186_abnormal_redox_activity0.50787942
131MP0006072_abnormal_retinal_apoptosis0.50218957
132MP0005408_hypopigmentation0.49513434
133MP0003448_altered_tumor_morphology0.48731095
134MP0000266_abnormal_heart_morphology0.48257215
135MP0003936_abnormal_reproductive_system0.47202937

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.93112642
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.56459191
3Birth length less than 3rd percentile (HP:0003561)4.17365471
4Impulsivity (HP:0100710)3.74866603
5Abnormality of chromosome stability (HP:0003220)3.72935291
6Aplasia/Hypoplasia of the patella (HP:0006498)3.71629853
7Degeneration of anterior horn cells (HP:0002398)3.51932670
8Abnormality of the anterior horn cell (HP:0006802)3.51932670
9Abnormality of the labia minora (HP:0012880)3.47503765
10Patellar aplasia (HP:0006443)3.45829320
11Breast hypoplasia (HP:0003187)3.42324314
12Facial hemangioma (HP:0000329)3.39007798
13Medulloblastoma (HP:0002885)3.38500211
14Meckel diverticulum (HP:0002245)3.37343840
15Rhabdomyosarcoma (HP:0002859)3.31115662
16Rib fusion (HP:0000902)3.30667074
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.14394774
18Abnormality of the ileum (HP:0001549)3.12880318
19Supernumerary spleens (HP:0009799)3.11460899
20Abnormality of the preputium (HP:0100587)3.05452228
21Carpal bone hypoplasia (HP:0001498)3.02938059
22Shoulder girdle muscle weakness (HP:0003547)3.01634606
23Ectopic kidney (HP:0000086)2.98135239
24Hypoplastic pelvis (HP:0008839)2.97460067
25Ependymoma (HP:0002888)2.94764486
26Embryonal neoplasm (HP:0002898)2.92187369
27Absent radius (HP:0003974)2.90041994
28Absent thumb (HP:0009777)2.86666708
29Myelodysplasia (HP:0002863)2.82629094
30Small intestinal stenosis (HP:0012848)2.82545305
31Duodenal stenosis (HP:0100867)2.82545305
32Volvulus (HP:0002580)2.76230723
33Nephroblastoma (Wilms tumor) (HP:0002667)2.70305486
34Aplasia involving forearm bones (HP:0009822)2.69992122
35Absent forearm bone (HP:0003953)2.69992122
36Reticulocytopenia (HP:0001896)2.68242419
37Gonadotropin excess (HP:0000837)2.64410440
38Sloping forehead (HP:0000340)2.57905872
39Progressive external ophthalmoplegia (HP:0000590)2.55880954
40Colon cancer (HP:0003003)2.54770046
41Abnormality of the musculature of the pelvis (HP:0001469)2.53741665
42Abnormality of the hip-girdle musculature (HP:0001445)2.53741665
43Basal cell carcinoma (HP:0002671)2.48809749
44Embryonal renal neoplasm (HP:0011794)2.48322799
45Abnormality of the fingertips (HP:0001211)2.47969037
46Neoplasm of striated muscle (HP:0009728)2.47849403
47Abnormal lung lobation (HP:0002101)2.47179337
48Selective tooth agenesis (HP:0001592)2.46125523
49Squamous cell carcinoma (HP:0002860)2.44571270
50Abnormality of the renal collecting system (HP:0004742)2.38834657
51Septo-optic dysplasia (HP:0100842)2.37725341
52Scotoma (HP:0000575)2.35495523
53Neoplasm of the oral cavity (HP:0100649)2.34216242
54Capillary hemangiomas (HP:0005306)2.32366694
55Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.32085890
56Pelvic girdle muscle weakness (HP:0003749)2.31597266
57Aplasia/Hypoplasia of the sacrum (HP:0008517)2.31426173
58Duplicated collecting system (HP:0000081)2.31102993
59Proximal placement of thumb (HP:0009623)2.30954390
60Deviation of the thumb (HP:0009603)2.28435530
61Oral leukoplakia (HP:0002745)2.28256121
62Cafe-au-lait spot (HP:0000957)2.27949773
63Shawl scrotum (HP:0000049)2.27835070
64Sandal gap (HP:0001852)2.27483745
65Abnormality of the duodenum (HP:0002246)2.27449074
66Aplastic anemia (HP:0001915)2.26213018
67Agnosia (HP:0010524)2.26072320
68Progressive inability to walk (HP:0002505)2.25777948
69Bone marrow hypocellularity (HP:0005528)2.25265815
70Clubbing of toes (HP:0100760)2.23807433
71Prominent nose (HP:0000448)2.23097794
72Long eyelashes (HP:0000527)2.20765043
73Abnormality of cells of the erythroid lineage (HP:0012130)2.20486716
74Cortical dysplasia (HP:0002539)2.20415792
75Horseshoe kidney (HP:0000085)2.19889619
76Papillary thyroid carcinoma (HP:0002895)2.17762614
77Abnormality of the carotid arteries (HP:0005344)2.16281854
78Aplasia/Hypoplasia of the sternum (HP:0006714)2.15357575
79Abnormal number of erythroid precursors (HP:0012131)2.14422818
80Short thumb (HP:0009778)2.13687124
81Pendular nystagmus (HP:0012043)2.13446579
82Atresia of the external auditory canal (HP:0000413)2.13270920
83Neoplasm of the colon (HP:0100273)2.13251624
84Acute myeloid leukemia (HP:0004808)2.12461002
85Multiple enchondromatosis (HP:0005701)2.11993871
86Increased nuchal translucency (HP:0010880)2.10711150
87Aplasia/hypoplasia of the humerus (HP:0006507)2.05727714
88Astrocytoma (HP:0009592)2.03319157
89Abnormality of the astrocytes (HP:0100707)2.03319157
90Intestinal atresia (HP:0011100)1.98663251
91Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.98535379
92Short 4th metacarpal (HP:0010044)1.98535379
93Absent septum pellucidum (HP:0001331)1.97652802
94Triphalangeal thumb (HP:0001199)1.97531741
95Microglossia (HP:0000171)1.96711175
96Abnormality of DNA repair (HP:0003254)1.96402748
97Pseudobulbar signs (HP:0002200)1.95287772
98Limb hypertonia (HP:0002509)1.91487470
99Glioma (HP:0009733)1.90777905
100Abnormality of placental membranes (HP:0011409)1.90435371
101Amniotic constriction ring (HP:0009775)1.90435371
102Abnormality of the septum pellucidum (HP:0007375)1.90276353
10311 pairs of ribs (HP:0000878)1.90205172
104Tracheoesophageal fistula (HP:0002575)1.89950121
105Biliary tract neoplasm (HP:0100574)1.89852237
106Oligodactyly (HP:0012165)1.89742531
107Neoplasm of the pancreas (HP:0002894)1.88065955
108Premature graying of hair (HP:0002216)1.86180558
109Short humerus (HP:0005792)1.85410158
110Abnormality of chromosome segregation (HP:0002916)1.83894506
111Choanal atresia (HP:0000453)1.82708629
112Overlapping toe (HP:0001845)1.82538195
113Atrophy/Degeneration involving motor neurons (HP:0007373)1.82083039
114Central scotoma (HP:0000603)1.81795827
115Premature ovarian failure (HP:0008209)1.81036665
116Stenosis of the external auditory canal (HP:0000402)1.80994710
117Rectovaginal fistula (HP:0000143)1.80622730
118Rectal fistula (HP:0100590)1.80622730
119Amaurosis fugax (HP:0100576)1.79820257
120Abnormality of the phalanges of the hallux (HP:0010057)1.79625624
121Horizontal nystagmus (HP:0000666)1.79276807
122Long clavicles (HP:0000890)1.78471544
123Intestinal fistula (HP:0100819)1.78317874
124Arteriovenous malformation (HP:0100026)1.77939340
125Abnormality of cochlea (HP:0000375)1.77199900
126Aplasia of the musculature (HP:0100854)1.74499054
127Abnormal number of incisors (HP:0011064)1.73155407
128Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72703017
129Median cleft lip (HP:0000161)1.72153030
130Abnormality of abdominal situs (HP:0011620)1.71907144
131Abdominal situs inversus (HP:0003363)1.71907144
132Oligodactyly (hands) (HP:0001180)1.71901745
133Decreased activity of mitochondrial respiratory chain (HP:0008972)1.71773624
134Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.71773624
135Missing ribs (HP:0000921)1.71574494
136Rough bone trabeculation (HP:0100670)1.71447114
137Generalized hypotonia (HP:0001290)1.70989891
138Supernumerary ribs (HP:0005815)1.69981223
139Optic nerve hypoplasia (HP:0000609)1.63077884
140Ovarian neoplasm (HP:0100615)1.62610146
141Short tibia (HP:0005736)1.61140950
142Male infertility (HP:0003251)1.58493675
143Abnormality of pyrimidine metabolism (HP:0004353)1.55950451
144Hyperglycinemia (HP:0002154)1.55871117

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.95771012
2CDK123.93855091
3NEK23.80703731
4WEE13.60206285
5TRIM283.03094102
6TTK2.91387280
7SRPK12.62568418
8ACVR1B2.51625139
9CHEK22.43849323
10BUB12.39314278
11SIK32.37755558
12PBK2.36594696
13MKNK22.32496909
14PLK12.30703697
15BRSK22.26595401
16MKNK12.22790098
17PLK42.06423212
18ERBB31.99444523
19PLK31.89559195
20EIF2AK11.86033168
21AURKB1.80170284
22LATS11.76765249
23RPS6KA41.72231379
24STK101.71160781
25DYRK31.70529448
26CDK71.70150099
27CHEK11.66139357
28BCR1.65201922
29STK31.63043085
30MAP3K41.62377104
31LATS21.62359849
32YES11.56323619
33MAP3K61.52434956
34RPS6KB21.51325747
35CDK191.50261467
36STK38L1.50149949
37CDK41.50107888
38ATR1.49815492
39EEF2K1.46869669
40TLK11.40430484
41MAP3K81.38422795
42AURKA1.37946623
43MAP2K71.37841377
44VRK11.33532257
45ATM1.32409660
46NEK11.25706575
47MELK1.23846591
48STK41.23277371
49WNK31.22936282
50TAF11.22882155
51MAP3K91.19203505
52CDK61.15373549
53MAP3K101.10641231
54CDK21.09924742
55BRSK11.07790074
56EIF2AK21.05818643
57ALK1.01345267
58TSSK60.97912883
59UHMK10.97740841
60PIM10.96154835
61PASK0.92972607
62SCYL20.90154718
63NME20.89667566
64EIF2AK30.89493993
65CDK90.88149477
66PNCK0.87866501
67TAOK10.83944579
68TGFBR10.81354098
69VRK20.81293674
70CDK10.80210563
71STK160.79996215
72NEK90.79639076
73CASK0.79545463
74PLK20.77951003
75BRAF0.76920267
76FRK0.74388631
77KSR10.73639960
78BRD40.71556990
79MAPK130.70972619
80ZAK0.70546707
81MARK30.67360885
82NEK60.64425933
83STK240.62873461
84FLT30.60790377
85EPHA20.59056674
86ERBB40.58673010
87CSNK2A20.56845256
88JAK30.53563816
89MINK10.53438014
90CDK80.52349377
91TAOK30.52311795
92MST40.51144613
93MTOR0.50399555
94RPS6KB10.50379633
95MAP2K30.49922435
96RPS6KA50.47680388
97CSNK2A10.47153788
98DYRK1B0.46798613
99MAPK140.45835574
100NUAK10.44587753
101CSNK1D0.43402259
102CSNK1E0.42962097
103GRK60.41698970
104PRKDC0.39987840
105PAK40.37210132
106RAF10.36934605
107TEC0.36091929
108PAK10.35803988
109NLK0.35522706
110CCNB10.35255851
111MAP3K30.35057903
112CAMK1D0.34934671
113PRKCI0.34267356
114MOS0.34102546
115MAPK10.31834007
116AKT10.31653732
117IRAK20.31484424
118CDK180.31182740
119FGFR30.30156532
120DYRK20.29444481
121MAP3K50.29067215
122GSK3B0.28707211
123CSNK1G10.27919018
124PKN20.27855170
125CLK10.26220179
126TNIK0.25251553
127CDK11A0.24224851
128CDK140.23949866
129CDK30.22963514
130CHUK0.22822671
131MAPK100.21932865
132TYRO30.21894738

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.16257108
2Mismatch repair_Homo sapiens_hsa034303.93824154
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.80479912
4Cell cycle_Homo sapiens_hsa041103.54847879
5Homologous recombination_Homo sapiens_hsa034403.29501417
6RNA transport_Homo sapiens_hsa030133.27696270
7Fanconi anemia pathway_Homo sapiens_hsa034602.96420838
8Spliceosome_Homo sapiens_hsa030402.94464798
9Base excision repair_Homo sapiens_hsa034102.74378665
10Nucleotide excision repair_Homo sapiens_hsa034202.70165952
11Steroid biosynthesis_Homo sapiens_hsa001002.64110120
12RNA polymerase_Homo sapiens_hsa030202.61304646
13One carbon pool by folate_Homo sapiens_hsa006702.56475613
14* Basal transcription factors_Homo sapiens_hsa030222.55157237
15Non-homologous end-joining_Homo sapiens_hsa034502.54945314
16mRNA surveillance pathway_Homo sapiens_hsa030152.47337405
17RNA degradation_Homo sapiens_hsa030182.46455364
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09273790
19p53 signaling pathway_Homo sapiens_hsa041152.05020516
20Ribosome_Homo sapiens_hsa030101.91180081
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91082598
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85982393
23Pyrimidine metabolism_Homo sapiens_hsa002401.78112831
24Protein export_Homo sapiens_hsa030601.76282835
25Systemic lupus erythematosus_Homo sapiens_hsa053221.72779390
26Oocyte meiosis_Homo sapiens_hsa041141.66242685
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.49741812
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.39832629
29MicroRNAs in cancer_Homo sapiens_hsa052061.22069306
30* Herpes simplex infection_Homo sapiens_hsa051681.20316158
31Viral carcinogenesis_Homo sapiens_hsa052031.17718511
32Pyruvate metabolism_Homo sapiens_hsa006201.16112531
33Proteasome_Homo sapiens_hsa030501.14845502
34Vitamin B6 metabolism_Homo sapiens_hsa007501.14728489
35TGF-beta signaling pathway_Homo sapiens_hsa043501.05354004
36Epstein-Barr virus infection_Homo sapiens_hsa051691.01554293
37Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93743065
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92784950
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92479145
40Selenocompound metabolism_Homo sapiens_hsa004500.92180610
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92114625
42HTLV-I infection_Homo sapiens_hsa051660.91606666
43Purine metabolism_Homo sapiens_hsa002300.90500580
44Propanoate metabolism_Homo sapiens_hsa006400.89832597
45Thyroid cancer_Homo sapiens_hsa052160.86651411
46Small cell lung cancer_Homo sapiens_hsa052220.83820280
47Alcoholism_Homo sapiens_hsa050340.81290551
48Antigen processing and presentation_Homo sapiens_hsa046120.79491629
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77560342
50Colorectal cancer_Homo sapiens_hsa052100.76073364
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75680482
52Pancreatic cancer_Homo sapiens_hsa052120.72361967
53Adherens junction_Homo sapiens_hsa045200.70760871
54Hippo signaling pathway_Homo sapiens_hsa043900.70635634
55Prostate cancer_Homo sapiens_hsa052150.69854533
56mTOR signaling pathway_Homo sapiens_hsa041500.68163473
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.68161665
58Notch signaling pathway_Homo sapiens_hsa043300.67651450
59Hepatitis B_Homo sapiens_hsa051610.62811867
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59289314
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51385100
62Chronic myeloid leukemia_Homo sapiens_hsa052200.51042375
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50512647
64Lysine degradation_Homo sapiens_hsa003100.50422251
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.47502507
66FoxO signaling pathway_Homo sapiens_hsa040680.47236465
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.47236440
68Basal cell carcinoma_Homo sapiens_hsa052170.45919615
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.44995678
70Folate biosynthesis_Homo sapiens_hsa007900.44743098
71Caffeine metabolism_Homo sapiens_hsa002320.44091378
72Pathways in cancer_Homo sapiens_hsa052000.44032609
73Pentose phosphate pathway_Homo sapiens_hsa000300.43429588
74Non-small cell lung cancer_Homo sapiens_hsa052230.41989431
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41632073
76Apoptosis_Homo sapiens_hsa042100.41012876
77Olfactory transduction_Homo sapiens_hsa047400.37855694
78Influenza A_Homo sapiens_hsa051640.37777214
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.36161177
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36142312
81Huntingtons disease_Homo sapiens_hsa050160.35863481
82Endometrial cancer_Homo sapiens_hsa052130.35270318
83Measles_Homo sapiens_hsa051620.34923854
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33751408
85Fatty acid elongation_Homo sapiens_hsa000620.33490765
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33105595
87Dorso-ventral axis formation_Homo sapiens_hsa043200.32748957
88Biosynthesis of amino acids_Homo sapiens_hsa012300.32607217
89Melanoma_Homo sapiens_hsa052180.32126625
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31313539
91Primary immunodeficiency_Homo sapiens_hsa053400.29975040
92Bladder cancer_Homo sapiens_hsa052190.29742516
93Wnt signaling pathway_Homo sapiens_hsa043100.29578184
94Renal cell carcinoma_Homo sapiens_hsa052110.29509792
95Hedgehog signaling pathway_Homo sapiens_hsa043400.29142539
96HIF-1 signaling pathway_Homo sapiens_hsa040660.28796885
97Fatty acid biosynthesis_Homo sapiens_hsa000610.28025186
98Phototransduction_Homo sapiens_hsa047440.27316404
99Metabolic pathways_Homo sapiens_hsa011000.26945109
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26568911
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24745499
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24234796
103Acute myeloid leukemia_Homo sapiens_hsa052210.23943601
104Linoleic acid metabolism_Homo sapiens_hsa005910.22687250
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22338097
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.20852644
107Circadian rhythm_Homo sapiens_hsa047100.20848365
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20601774
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20201025
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.20117813
111Choline metabolism in cancer_Homo sapiens_hsa052310.19327163
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19131763
113Hematopoietic cell lineage_Homo sapiens_hsa046400.18534277
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18156208
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.17781329
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17367615
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16587593
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.16092901
119Shigellosis_Homo sapiens_hsa051310.16087570
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16029040
121Legionellosis_Homo sapiens_hsa051340.15472503
122Inositol phosphate metabolism_Homo sapiens_hsa005620.14181400
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.14041690
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13607835
125Proteoglycans in cancer_Homo sapiens_hsa052050.13592501
126Regulation of autophagy_Homo sapiens_hsa041400.12713289
127Carbon metabolism_Homo sapiens_hsa012000.12706629
128Sulfur metabolism_Homo sapiens_hsa009200.11132263
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.09676566
130Sulfur relay system_Homo sapiens_hsa041220.06719129
131Parkinsons disease_Homo sapiens_hsa050120.04712376
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.04679341

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