TAF4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.20289320
2nuclear pore organization (GO:0006999)5.14566928
3mitotic metaphase plate congression (GO:0007080)5.02575476
4piRNA metabolic process (GO:0034587)4.98450838
5regulation of histone H3-K9 methylation (GO:0051570)4.71385945
6synapsis (GO:0007129)4.49144491
7metaphase plate congression (GO:0051310)4.45876008
8synaptonemal complex assembly (GO:0007130)4.31102495
9DNA replication checkpoint (GO:0000076)4.28395820
10meiotic chromosome segregation (GO:0045132)4.23180791
11mitotic nuclear envelope disassembly (GO:0007077)4.23012914
12protein localization to kinetochore (GO:0034501)4.19895710
13attachment of spindle microtubules to kinetochore (GO:0008608)4.12509723
14monoubiquitinated protein deubiquitination (GO:0035520)4.07401830
15regulation of spindle organization (GO:0090224)4.06840789
16telomere maintenance via semi-conservative replication (GO:0032201)4.06021424
17DNA methylation involved in gamete generation (GO:0043046)4.04826361
18regulation of meiosis I (GO:0060631)4.03828246
19pore complex assembly (GO:0046931)4.01063279
20membrane disassembly (GO:0030397)3.95688033
21nuclear envelope disassembly (GO:0051081)3.95688033
22ribosome biogenesis (GO:0042254)3.92653461
23ribosome assembly (GO:0042255)3.90896916
24synaptonemal complex organization (GO:0070193)3.89555892
25purine nucleobase biosynthetic process (GO:0009113)3.85219900
26mitotic chromosome condensation (GO:0007076)3.83567953
27nucleobase biosynthetic process (GO:0046112)3.79309213
28protein localization to chromosome, centromeric region (GO:0071459)3.78086805
29protein K6-linked ubiquitination (GO:0085020)3.76357378
30maturation of SSU-rRNA (GO:0030490)3.67813598
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.67250187
32negative regulation of histone methylation (GO:0031061)3.62414738
33regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.61494855
34telomere maintenance via recombination (GO:0000722)3.61232215
35establishment of chromosome localization (GO:0051303)3.55449134
36regulation of RNA export from nucleus (GO:0046831)3.55436942
37male meiosis (GO:0007140)3.55355044
38DNA replication initiation (GO:0006270)3.53102971
39regulation of mitotic spindle organization (GO:0060236)3.51413474
40kinetochore organization (GO:0051383)3.50159825
41mitotic sister chromatid cohesion (GO:0007064)3.48052146
42chromatin remodeling at centromere (GO:0031055)3.47244224
43establishment of integrated proviral latency (GO:0075713)3.45449737
44mitotic recombination (GO:0006312)3.44871000
45meiotic nuclear division (GO:0007126)3.44388952
46regulation of double-strand break repair via homologous recombination (GO:0010569)3.42710042
47DNA duplex unwinding (GO:0032508)3.40363491
48CENP-A containing nucleosome assembly (GO:0034080)3.37420890
49regulation of translational fidelity (GO:0006450)3.37284449
50reciprocal meiotic recombination (GO:0007131)3.33991892
51reciprocal DNA recombination (GO:0035825)3.33991892
52cellular protein complex localization (GO:0034629)3.32389910
53kinetochore assembly (GO:0051382)3.32200366
54DNA topological change (GO:0006265)3.32071585
55positive regulation of chromosome segregation (GO:0051984)3.31987936
56DNA replication-independent nucleosome assembly (GO:0006336)3.30114092
57DNA replication-independent nucleosome organization (GO:0034724)3.30114092
58DNA geometric change (GO:0032392)3.28795134
59regulation of chromosome segregation (GO:0051983)3.26206945
60spindle checkpoint (GO:0031577)3.25910549
61folic acid-containing compound biosynthetic process (GO:0009396)3.25393967
62gene silencing by RNA (GO:0031047)3.24784132
63sister chromatid cohesion (GO:0007062)3.23407456
64chromosome organization involved in meiosis (GO:0070192)3.22489763
65protein complex localization (GO:0031503)3.21336622
66histone H2A monoubiquitination (GO:0035518)3.20832291
67somatic hypermutation of immunoglobulin genes (GO:0016446)3.18138751
68somatic diversification of immune receptors via somatic mutation (GO:0002566)3.18138751
69mitotic sister chromatid segregation (GO:0000070)3.16917514
70protein localization to chromosome (GO:0034502)3.16742019
71nuclear envelope organization (GO:0006998)3.16536322
72histone exchange (GO:0043486)3.16133998
73negative regulation of DNA repair (GO:0045738)3.15894343
74ribonucleoprotein complex biogenesis (GO:0022613)3.15772867
75male meiosis I (GO:0007141)3.15570302
76negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.15149284
77regulation of centriole replication (GO:0046599)3.13986732
78mitotic spindle checkpoint (GO:0071174)3.11420492
79negative regulation of chromosome segregation (GO:0051985)3.11388871
80meiotic cell cycle process (GO:1903046)3.09931200
81regulation of mitotic metaphase/anaphase transition (GO:0030071)3.09802550
82regulation of DNA endoreduplication (GO:0032875)3.09585916
83DNA replication-dependent nucleosome organization (GO:0034723)3.09509442
84DNA replication-dependent nucleosome assembly (GO:0006335)3.09509442
85DNA conformation change (GO:0071103)3.08486844
86spindle assembly checkpoint (GO:0071173)3.08309699
87negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.07226373
88negative regulation of sister chromatid segregation (GO:0033046)3.07226373
89negative regulation of mitotic sister chromatid separation (GO:2000816)3.07226373
90negative regulation of mitotic sister chromatid segregation (GO:0033048)3.07226373
91mitotic spindle assembly checkpoint (GO:0007094)3.07003618
92non-recombinational repair (GO:0000726)3.05124764
93double-strand break repair via nonhomologous end joining (GO:0006303)3.05124764
94formation of translation preinitiation complex (GO:0001731)3.04060920
95regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.03553748
96inner cell mass cell proliferation (GO:0001833)3.01826051
97regulation of translational termination (GO:0006449)3.00718976
98meiosis I (GO:0007127)2.99861982
99IMP metabolic process (GO:0046040)2.99260813
100negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.99215458
101positive regulation of histone methylation (GO:0031062)2.97563526
102positive regulation of histone H3-K4 methylation (GO:0051571)2.97082836
103telomere maintenance via telomere lengthening (GO:0010833)2.94829471
104DNA synthesis involved in DNA repair (GO:0000731)2.94546388
105nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.94291225
106ATP-dependent chromatin remodeling (GO:0043044)2.94234722
107chromosome segregation (GO:0007059)2.94228259
108nucleotide-excision repair, DNA gap filling (GO:0006297)2.94157747
109maturation of 5.8S rRNA (GO:0000460)2.94148589
110maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93289885
111DNA strand elongation involved in DNA replication (GO:0006271)2.93203808
112regulation of mitotic sister chromatid separation (GO:0010965)2.89495278
113regulation of mitotic sister chromatid segregation (GO:0033047)2.89495278
114regulation of sister chromatid segregation (GO:0033045)2.89495278
115rRNA processing (GO:0006364)2.89377399
116positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.88603777
117positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.88603777
118positive regulation of mitotic sister chromatid separation (GO:1901970)2.88603777
119chromatin assembly (GO:0031497)2.87638195
120regulation of histone methylation (GO:0031060)2.87510956
121rRNA metabolic process (GO:0016072)2.85894598
122IMP biosynthetic process (GO:0006188)2.85206477
123chromatin assembly or disassembly (GO:0006333)2.85176523
124negative regulation of meiosis (GO:0045835)2.84210347
125negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.83893312
126sister chromatid segregation (GO:0000819)2.83523650
127ribosomal small subunit biogenesis (GO:0042274)2.82477432
128pre-miRNA processing (GO:0031054)2.81878861
129chromosome condensation (GO:0030261)2.81547777
130regulation of double-strand break repair (GO:2000779)2.80331509
131oocyte maturation (GO:0001556)2.79841645
132DNA packaging (GO:0006323)2.79433976
133DNA strand elongation (GO:0022616)2.78612792
134DNA unwinding involved in DNA replication (GO:0006268)2.77884595
135rRNA modification (GO:0000154)2.73915996

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.52146373
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.56282574
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.79801118
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.67422961
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.24583306
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.02340778
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.88999904
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.73646689
9AR_21909140_ChIP-Seq_LNCAP_Human2.49753295
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48567444
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.43776048
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.40051042
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.36174906
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33055148
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32245439
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.24323392
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.23264206
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.15976409
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15582485
20VDR_23849224_ChIP-Seq_CD4+_Human2.12973089
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.12217579
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.10429986
23MYCN_18555785_ChIP-Seq_MESCs_Mouse2.09352855
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02464021
25XRN2_22483619_ChIP-Seq_HELA_Human1.97946473
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96301594
27MYC_22102868_ChIP-Seq_BL_Human1.85626147
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78094702
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77747308
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77422050
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76886697
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72466192
33FOXP3_21729870_ChIP-Seq_TREG_Human1.65496643
34KDM5A_27292631_Chip-Seq_BREAST_Human1.63287761
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.61559392
36* DCP1A_22483619_ChIP-Seq_HELA_Human1.60493053
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59188570
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56774324
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.56544798
40GABP_19822575_ChIP-Seq_HepG2_Human1.54211025
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52616860
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52538287
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.50985073
44ELK1_19687146_ChIP-ChIP_HELA_Human1.48931914
45TTF2_22483619_ChIP-Seq_HELA_Human1.48829218
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46945118
47KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44592091
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44238461
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44238461
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44238461
51* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44118729
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44076536
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43834394
54* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.43400919
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38600433
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36614732
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28106035
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26057434
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25375054
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23376844
61* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23182514
62CIITA_25753668_ChIP-Seq_RAJI_Human1.23049270
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22322474
64TFEB_21752829_ChIP-Seq_HELA_Human1.22178666
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21662595
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17009504
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12641507
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12501680
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11201470
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10328727
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10214403
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09349355
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08805984
74VDR_21846776_ChIP-Seq_THP-1_Human1.06668838
75SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06379801
76* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03760373
77* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00841590
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98069849
79MYB_26560356_Chip-Seq_TH1_Human0.96433011
80MYC_18940864_ChIP-ChIP_HL60_Human0.96306204
81THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93799301
82SPI1_23547873_ChIP-Seq_NB4_Human0.89798600
83ZNF263_19887448_ChIP-Seq_K562_Human0.89558280
84ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88958107
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87498787
86GATA1_22025678_ChIP-Seq_K562_Human0.87088521
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86831223
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85485604
89MYB_21317192_ChIP-Seq_ERMYB_Mouse0.84856291
90YY1_21170310_ChIP-Seq_MESCs_Mouse0.84597172
91MYB_26560356_Chip-Seq_TH2_Human0.84158569
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83782121
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83370810
94PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82226879
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.82035400
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.81752155
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81389214
98SRF_21415370_ChIP-Seq_HL-1_Mouse0.79920075
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79783809
100FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.79451041
101NCOR1_26117541_ChIP-Seq_K562_Human0.78686530
102ATF3_27146783_Chip-Seq_COLON_Human0.77844703
103ELK1_22589737_ChIP-Seq_MCF10A_Human0.77678179
104ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.77526304
105SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77414129
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.76997241
107NANOG_21062744_ChIP-ChIP_HESCs_Human0.76061388
108STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.75871444
109EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.75056673
110MAF_26560356_Chip-Seq_TH1_Human0.74706453
111CHD1_26751641_Chip-Seq_LNCaP_Human0.74599532
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.74123718
113PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.73526580
114ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.73405197
115SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.71407798

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.80306660
2MP0008057_abnormal_DNA_replication4.35497225
3MP0008877_abnormal_DNA_methylation4.13680909
4MP0010094_abnormal_chromosome_stability4.05582075
5MP0003111_abnormal_nucleus_morphology3.92762732
6MP0004957_abnormal_blastocyst_morpholog3.69287916
7MP0003077_abnormal_cell_cycle3.62272033
8MP0008058_abnormal_DNA_repair3.17243768
9MP0008007_abnormal_cellular_replicative2.92691285
10MP0010352_gastrointestinal_tract_polyps2.53250030
11MP0010307_abnormal_tumor_latency2.44815636
12* MP0003786_premature_aging2.26055392
13MP0000350_abnormal_cell_proliferation2.16007415
14MP0002396_abnormal_hematopoietic_system2.11148964
15MP0001730_embryonic_growth_arrest2.06978640
16MP0003123_paternal_imprinting2.01465643
17* MP0002210_abnormal_sex_determination1.98178528
18MP0004808_abnormal_hematopoietic_stem1.97486943
19MP0008932_abnormal_embryonic_tissue1.87719069
20MP0003763_abnormal_thymus_physiology1.76963363
21MP0009697_abnormal_copulation1.71813887
22* MP0001929_abnormal_gametogenesis1.71417311
23MP0005380_embryogenesis_phenotype1.68215263
24MP0001672_abnormal_embryogenesis/_devel1.68215263
25MP0003718_maternal_effect1.67853944
26MP0005076_abnormal_cell_differentiation1.64860521
27* MP0001145_abnormal_male_reproductive1.63919357
28MP0005397_hematopoietic_system_phenotyp1.61042556
29MP0001545_abnormal_hematopoietic_system1.61042556
30MP0005451_abnormal_body_composition1.55135640
31MP0003984_embryonic_growth_retardation1.52912369
32MP0001697_abnormal_embryo_size1.50368552
33MP0002088_abnormal_embryonic_growth/wei1.50035778
34MP0002796_impaired_skin_barrier1.49611344
35MP0000490_abnormal_crypts_of1.48892371
36* MP0000653_abnormal_sex_gland1.48863635
37MP0009333_abnormal_splenocyte_physiolog1.48140606
38MP0002019_abnormal_tumor_incidence1.39210654
39MP0002086_abnormal_extraembryonic_tissu1.37269213
40MP0002085_abnormal_embryonic_tissue1.30052382
41MP0002084_abnormal_developmental_patter1.28587752
42MP0002080_prenatal_lethality1.27171054
43MP0004197_abnormal_fetal_growth/weight/1.23957255
44MP0000313_abnormal_cell_death1.21606967
45MP0005501_abnormal_skin_physiology1.19770216
46MP0006035_abnormal_mitochondrial_morpho1.18712208
47MP0009278_abnormal_bone_marrow1.14155799
48* MP0008995_early_reproductive_senescence1.12749979
49MP0002398_abnormal_bone_marrow1.12597968
50MP0002877_abnormal_melanocyte_morpholog1.10239739
51MP0000703_abnormal_thymus_morphology1.09551840
52MP0001661_extended_life_span1.09315668
53* MP0001119_abnormal_female_reproductive1.08012818
54MP0002006_tumorigenesis1.05202410
55MP0002722_abnormal_immune_system1.03120627
56MP0006292_abnormal_olfactory_placode1.03117732
57MP0010234_abnormal_vibrissa_follicle0.99025726
58MP0000689_abnormal_spleen_morphology0.98015027
59MP0003941_abnormal_skin_development0.96843318
60MP0002405_respiratory_system_inflammati0.96291477
61MP0003656_abnormal_erythrocyte_physiolo0.93944407
62MP0000858_altered_metastatic_potential0.93827002
63MP0000358_abnormal_cell_content/0.91762142
64MP0005621_abnormal_cell_physiology0.91501369
65MP0003567_abnormal_fetal_cardiomyocyte0.91208161
66* MP0003698_abnormal_male_reproductive0.90477227
67MP0003448_altered_tumor_morphology0.87535652
68MP0009703_decreased_birth_body0.86037535
69MP0004185_abnormal_adipocyte_glucose0.85934369
70MP0002009_preneoplasia0.85106969
71MP0001800_abnormal_humoral_immune0.85088797
72MP0005671_abnormal_response_to0.83586056
73MP0001835_abnormal_antigen_presentation0.82092611
74MP0004233_abnormal_muscle_weight0.81743165
75MP0003890_abnormal_embryonic-extraembry0.81118160
76MP0000716_abnormal_immune_system0.79249051
77MP0002429_abnormal_blood_cell0.78568082
78MP0002166_altered_tumor_susceptibility0.78228626
79MP0001188_hyperpigmentation0.77638743
80MP0002132_abnormal_respiratory_system0.77611243
81* MP0003699_abnormal_female_reproductive0.76494095
82MP0002160_abnormal_reproductive_system0.75765076
83MP0000627_abnormal_mammary_gland0.74820161
84MP0005023_abnormal_wound_healing0.74074235
85MP0001216_abnormal_epidermal_layer0.73722400
86MP0000685_abnormal_immune_system0.73279590
87MP0001873_stomach_inflammation0.72813215
88MP0002254_reproductive_system_inflammat0.72696162
89MP0005384_cellular_phenotype0.72371893
90MP0003566_abnormal_cell_adhesion0.72248267
91MP0002723_abnormal_immune_serum0.71753941
92MP0001849_ear_inflammation0.71245742
93MP0002452_abnormal_antigen_presenting0.70818249
94MP0005389_reproductive_system_phenotype0.70713615
95MP0002420_abnormal_adaptive_immunity0.70699125
96MP0004947_skin_inflammation0.70528592
97MP0001853_heart_inflammation0.70391649
98MP0001819_abnormal_immune_cell0.69134567
99MP0000383_abnormal_hair_follicle0.69090959
100MP0003453_abnormal_keratinocyte_physiol0.69081927
101MP0003937_abnormal_limbs/digits/tail_de0.68949786
102MP0001915_intracranial_hemorrhage0.68821274
103MP0003943_abnormal_hepatobiliary_system0.68407479
104* MP0002161_abnormal_fertility/fecundity0.67903550
105MP0002163_abnormal_gland_morphology0.66562854
106MP0003828_pulmonary_edema0.65936226
107MP0003936_abnormal_reproductive_system0.64903436
108MP0005395_other_phenotype0.64821346
109MP0003121_genomic_imprinting0.64695380
110MP0001293_anophthalmia0.64198052
111MP0010155_abnormal_intestine_physiology0.63866387
112MP0006036_abnormal_mitochondrial_physio0.63561239
113MP0005000_abnormal_immune_tolerance0.62603188
114MP0009672_abnormal_birth_weight0.62085864
115MP0003221_abnormal_cardiomyocyte_apopto0.61918197
116MP0001881_abnormal_mammary_gland0.60799021
117MP0005310_abnormal_salivary_gland0.60582374
118MP0001346_abnormal_lacrimal_gland0.59027126
119MP0005666_abnormal_adipose_tissue0.58339006
120MP0005075_abnormal_melanosome_morpholog0.57347560
121MP0010678_abnormal_skin_adnexa0.57246580
122MP0008260_abnormal_autophagy0.56989711
123MP0001919_abnormal_reproductive_system0.56748877

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.54215717
2Chromsome breakage (HP:0040012)4.25301065
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.02320756
4Carpal bone hypoplasia (HP:0001498)3.70376715
5Microvesicular hepatic steatosis (HP:0001414)3.58216362
6Facial hemangioma (HP:0000329)3.55859792
7Breast hypoplasia (HP:0003187)3.46446840
8Impulsivity (HP:0100710)3.39916051
9* Abnormal spermatogenesis (HP:0008669)3.30952498
10Abnormality of chromosome stability (HP:0003220)3.24902362
11Nephroblastoma (Wilms tumor) (HP:0002667)3.23898263
12Progressive external ophthalmoplegia (HP:0000590)3.12825480
13Progressive muscle weakness (HP:0003323)3.09976750
14Embryonal renal neoplasm (HP:0011794)3.00885746
15Multiple enchondromatosis (HP:0005701)2.98553822
16Abnormality of the fingertips (HP:0001211)2.92596391
17Abnormality of the preputium (HP:0100587)2.90770828
18Patellar aplasia (HP:0006443)2.88789464
19Capillary hemangiomas (HP:0005306)2.88558473
20Increased nuchal translucency (HP:0010880)2.84817631
21* Azoospermia (HP:0000027)2.78157806
22Meckel diverticulum (HP:0002245)2.77949837
23Colon cancer (HP:0003003)2.75799619
24IgA deficiency (HP:0002720)2.74737120
25Abnormality of the labia minora (HP:0012880)2.74183128
2611 pairs of ribs (HP:0000878)2.70780786
27Irregular epiphyses (HP:0010582)2.68645167
28Selective tooth agenesis (HP:0001592)2.68563166
29Entropion (HP:0000621)2.67898409
30Rough bone trabeculation (HP:0100670)2.67793693
31Aplasia/Hypoplasia of the patella (HP:0006498)2.67436398
32Medulloblastoma (HP:0002885)2.67418463
33Prominent nose (HP:0000448)2.67021333
34Myelodysplasia (HP:0002863)2.66788189
35Ectopic kidney (HP:0000086)2.65347107
36IgM deficiency (HP:0002850)2.64571006
37Short middle phalanx of the 5th finger (HP:0004220)2.63399002
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.57007182
39Abnormality of the ileum (HP:0001549)2.56614480
40Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.56572650
41Abnormal lung lobation (HP:0002101)2.49834185
42Absent radius (HP:0003974)2.48798756
43Rhabdomyosarcoma (HP:0002859)2.47143009
44Reticulocytopenia (HP:0001896)2.43901664
45Deep philtrum (HP:0002002)2.43198311
46Homocystinuria (HP:0002156)2.42046351
47Abnormality of homocysteine metabolism (HP:0010919)2.42046351
48Abnormality of the anterior horn cell (HP:0006802)2.34948953
49Degeneration of anterior horn cells (HP:0002398)2.34948953
50Absent thumb (HP:0009777)2.34117241
51Ependymoma (HP:0002888)2.29015512
52Acute myeloid leukemia (HP:0004808)2.28597837
53Absent forearm bone (HP:0003953)2.26645782
54Aplasia involving forearm bones (HP:0009822)2.26645782
55Gonadotropin excess (HP:0000837)2.25843692
56Flat capital femoral epiphysis (HP:0003370)2.25320702
57Basal cell carcinoma (HP:0002671)2.24248379
58Acute lymphatic leukemia (HP:0006721)2.24157915
59Oral leukoplakia (HP:0002745)2.16901336
60Small intestinal stenosis (HP:0012848)2.16119176
61Duodenal stenosis (HP:0100867)2.16119176
62Pelvic girdle muscle weakness (HP:0003749)2.15202656
63Recurrent viral infections (HP:0004429)2.14085536
64Short thumb (HP:0009778)2.13382557
65Urethral obstruction (HP:0000796)2.11210586
66Proximal placement of thumb (HP:0009623)2.08931324
67Deviation of the thumb (HP:0009603)2.08701619
68Squamous cell carcinoma (HP:0002860)2.07302738
69Premature graying of hair (HP:0002216)2.06055369
70Bone marrow hypocellularity (HP:0005528)2.02550939
71Aplastic anemia (HP:0001915)2.02003720
72Biliary tract neoplasm (HP:0100574)2.01842371
73Abnormality of cells of the erythroid lineage (HP:0012130)2.01237428
74Sandal gap (HP:0001852)1.99382968
75Hypergonadotropic hypogonadism (HP:0000815)1.98875313
76Papillary thyroid carcinoma (HP:0002895)1.98827253
77Deep palmar crease (HP:0006191)1.98815106
78Volvulus (HP:0002580)1.98160757
79Pallor (HP:0000980)1.97178481
80Sparse lateral eyebrow (HP:0005338)1.96818904
81Choanal atresia (HP:0000453)1.96749400
82Overlapping toe (HP:0001845)1.96490147
83Microretrognathia (HP:0000308)1.96096181
84Neoplasm of the oral cavity (HP:0100649)1.95659882
85Neoplasm of the pancreas (HP:0002894)1.95486663
86Ureteral duplication (HP:0000073)1.94990550
87Secondary amenorrhea (HP:0000869)1.94528758
88Cafe-au-lait spot (HP:0000957)1.93602942
89Stillbirth (HP:0003826)1.93363416
90Neoplasm of the colon (HP:0100273)1.91996148
91Dysmetric saccades (HP:0000641)1.91762004
92Macrocytic anemia (HP:0001972)1.91484187
93Shoulder girdle muscle weakness (HP:0003547)1.91241414
94Sloping forehead (HP:0000340)1.91220861
95Abnormality of chromosome segregation (HP:0002916)1.91059515
96Abnormal trabecular bone morphology (HP:0100671)1.90025680
97Abnormality of DNA repair (HP:0003254)1.88568186
98Breast aplasia (HP:0100783)1.88291971
99Fatigue (HP:0012378)1.88049321
100Abnormality of cochlea (HP:0000375)1.87773302
101Abnormality of the salivary glands (HP:0010286)1.86990590
102Prostate neoplasm (HP:0100787)1.86272833
103Abnormality of the carotid arteries (HP:0005344)1.85889417
104Panhypogammaglobulinemia (HP:0003139)1.85717667
105Embryonal neoplasm (HP:0002898)1.85674637
106Clubbing of toes (HP:0100760)1.85217682
107Cleft eyelid (HP:0000625)1.84907896
108Long eyelashes (HP:0000527)1.84734442
109Spinal muscular atrophy (HP:0007269)1.84047532
110Combined immunodeficiency (HP:0005387)1.83934118
111Neoplasm of striated muscle (HP:0009728)1.83920170
112Septate vagina (HP:0001153)1.82742808
113Male infertility (HP:0003251)1.81946713
114Metaphyseal cupping (HP:0003021)1.81811567
115Glossoptosis (HP:0000162)1.81610611
116Aseptic necrosis (HP:0010885)1.81356139
117Aplasia/Hypoplasia of the earlobes (HP:0009906)1.81131319
118Premature ovarian failure (HP:0008209)1.80751678
119Lymphoma (HP:0002665)1.79989254
120Retrobulbar optic neuritis (HP:0100654)1.79602923
121Optic neuritis (HP:0100653)1.79602923
122Agnosia (HP:0010524)1.78319497
123Missing ribs (HP:0000921)1.78103243
124Horseshoe kidney (HP:0000085)1.76739562
125Gastrointestinal carcinoma (HP:0002672)1.75822878
126Malignant gastrointestinal tract tumors (HP:0006749)1.75822878
127Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75507832
128Duplicated collecting system (HP:0000081)1.75443181
129Abnormality of the proximal phalanges of the hand (HP:0009834)1.75264130
130Absent epiphyses (HP:0010577)1.74515253
131Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.74515253
132Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.73412132
133Tracheoesophageal fistula (HP:0002575)1.73206373
134Abnormality of the duodenum (HP:0002246)1.72631932
135Autoimmune hemolytic anemia (HP:0001890)1.72465268
136Cortical dysplasia (HP:0002539)1.72395196
137Amaurosis fugax (HP:0100576)1.71800356
138Atresia of the external auditory canal (HP:0000413)1.71630810
139Cellular immunodeficiency (HP:0005374)1.71337435
140Oligodactyly (HP:0012165)1.70615960
141Glioma (HP:0009733)1.70523497
142Broad palm (HP:0001169)1.70522743
143Poikiloderma (HP:0001029)1.69748904
144Small epiphyses (HP:0010585)1.69446281
145Facial cleft (HP:0002006)1.69058887
146Aplasia/Hypoplasia of the breasts (HP:0010311)1.68313867
147Hypoplasia of the pons (HP:0012110)1.66414027
148Neoplasm of the small intestine (HP:0100833)1.65672104
149Ankyloglossia (HP:0010296)1.65104978
150Abnormality of the fetal cardiovascular system (HP:0010948)1.64989424
151Abnormal umbilical cord blood vessels (HP:0011403)1.64989424
152Single umbilical artery (HP:0001195)1.64989424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.94502048
2CDK123.69018573
3WEE13.52726629
4BUB13.17119031
5NEK23.12151316
6MAP3K102.88449485
7ACVR1B2.86492730
8EIF2AK12.64648586
9BRSK22.40540915
10PRPF4B2.28807042
11TTK2.28411770
12STK32.07653266
13PLK42.04781523
14STK38L2.01869984
15LATS11.99598987
16TSSK61.92813613
17MKNK21.86052678
18PLK11.84071899
19SMG11.76668423
20SRPK11.73155750
21CDK41.66744172
22RPS6KA41.62533351
23NME21.62280194
24CHEK21.60360170
25EIF2AK31.59046419
26EPHA21.56384960
27DYRK31.56370800
28LATS21.54986162
29MAP3K31.54520235
30STK101.54037979
31MAP3K131.50121633
32AURKB1.49654545
33CDK71.48660356
34PLK31.40689759
35ATR1.40348165
36CDK81.39112764
37CHEK11.37515722
38PIM11.36984584
39BRAF1.33711985
40MAP4K11.33483830
41PNCK1.25130963
42CLK11.20374355
43STK241.19271342
44MELK1.18243027
45NLK1.17267620
46CDK191.17211549
47MKNK11.13699399
48NEK11.13638389
49MARK31.12507109
50IRAK31.08959760
51MAP2K31.08304554
52RPS6KB21.07678719
53CDK91.07508335
54TAOK11.07320493
55TAF11.06033141
56ATM1.03230493
57PBK1.01352589
58MAP3K81.00437355
59BRD40.99412772
60EEF2K0.99131423
61BRSK10.98701122
62TXK0.98361285
63STK40.97187858
64MST40.94015399
65VRK10.93474655
66CAMK1G0.91729611
67JAK30.91636361
68ZAK0.86651966
69CDK20.85118053
70CHUK0.84839982
71MAP3K90.84305305
72ALK0.83232206
73PIM20.81253517
74CDK60.80001327
75NUAK10.75834803
76PDK30.72336290
77PDK40.72336290
78AURKA0.71581933
79PDK20.70630298
80SCYL20.69415112
81VRK20.68619239
82TLK10.64549003
83KSR20.61836359
84TAOK20.61247168
85CDK10.59611966
86TEC0.59073025
87MTOR0.58948213
88NEK60.58927949
89IKBKB0.58858944
90RAF10.57178415
91MAP3K50.55582281
92TESK20.54436533
93RPS6KA50.53484588
94TGFBR10.52230459
95CAMK1D0.52046622
96TYK20.51691104
97PASK0.47326330
98STK160.47024128
99EIF2AK20.45928108
100FLT30.45725427
101MAPK110.44290229
102NEK90.43401338
103MAP3K110.43329798
104MAP3K60.43024081
105CSNK2A20.42670298
106RPS6KB10.41198669
107ZAP700.40392902
108CSNK1E0.39485287
109BMX0.38828055
110FGFR30.38207214
111NME10.37915040
112RIPK40.36338659
113ICK0.34509549
114ARAF0.34063902
115IRAK20.32590655
116CDK30.31899150
117PRKCI0.31609078
118ERBB40.31127158
119ABL20.30310905
120CSNK2A10.30303296
121MAPK140.28679876
122GSK3B0.28440012
123MAPK100.28397461
124PAK10.28118732
125ITK0.26999035
126PRKDC0.26338387
127MAPK10.26322084
128MAP3K140.25195941
129PDGFRB0.24225365

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.76909317
2RNA polymerase_Homo sapiens_hsa030203.53530249
3RNA transport_Homo sapiens_hsa030133.36392430
4DNA replication_Homo sapiens_hsa030303.23095156
5Cell cycle_Homo sapiens_hsa041102.99265434
6Mismatch repair_Homo sapiens_hsa034302.87816143
7Spliceosome_Homo sapiens_hsa030402.71791354
8Homologous recombination_Homo sapiens_hsa034402.57517449
9* Basal transcription factors_Homo sapiens_hsa030222.43773260
10Fanconi anemia pathway_Homo sapiens_hsa034602.34681084
11Nucleotide excision repair_Homo sapiens_hsa034202.20706246
12Base excision repair_Homo sapiens_hsa034102.03983571
13Pyrimidine metabolism_Homo sapiens_hsa002402.01979512
14RNA degradation_Homo sapiens_hsa030182.00884293
15mRNA surveillance pathway_Homo sapiens_hsa030152.00214536
16p53 signaling pathway_Homo sapiens_hsa041151.98907585
17One carbon pool by folate_Homo sapiens_hsa006701.92010275
18Proteasome_Homo sapiens_hsa030501.87399652
19Vitamin B6 metabolism_Homo sapiens_hsa007501.80427198
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.76819627
21Non-homologous end-joining_Homo sapiens_hsa034501.66597316
22Ribosome_Homo sapiens_hsa030101.63956327
23Epstein-Barr virus infection_Homo sapiens_hsa051691.49349454
24* Herpes simplex infection_Homo sapiens_hsa051681.46439236
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41865579
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33886238
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.25233672
28Antigen processing and presentation_Homo sapiens_hsa046121.18791780
29Selenocompound metabolism_Homo sapiens_hsa004501.09789671
30Purine metabolism_Homo sapiens_hsa002301.06923802
31Viral carcinogenesis_Homo sapiens_hsa052031.05625715
32Small cell lung cancer_Homo sapiens_hsa052221.04426055
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02755935
34Oocyte meiosis_Homo sapiens_hsa041140.99639209
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98896628
36HTLV-I infection_Homo sapiens_hsa051660.98830436
37NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98259390
38Measles_Homo sapiens_hsa051620.96184634
39Thyroid cancer_Homo sapiens_hsa052160.95732726
40MicroRNAs in cancer_Homo sapiens_hsa052060.95416748
41Legionellosis_Homo sapiens_hsa051340.94296998
42Influenza A_Homo sapiens_hsa051640.94217222
43TGF-beta signaling pathway_Homo sapiens_hsa043500.89743688
44Pentose phosphate pathway_Homo sapiens_hsa000300.88687291
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80972768
46Hepatitis B_Homo sapiens_hsa051610.78757123
47Jak-STAT signaling pathway_Homo sapiens_hsa046300.77807957
48Primary immunodeficiency_Homo sapiens_hsa053400.77185700
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75017019
50Apoptosis_Homo sapiens_hsa042100.73157728
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67597734
52Systemic lupus erythematosus_Homo sapiens_hsa053220.67315409
53Hematopoietic cell lineage_Homo sapiens_hsa046400.65798121
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.64005526
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.61939742
56T cell receptor signaling pathway_Homo sapiens_hsa046600.61677101
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61558354
58FoxO signaling pathway_Homo sapiens_hsa040680.61398778
59Graft-versus-host disease_Homo sapiens_hsa053320.60776582
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.60571141
61Folate biosynthesis_Homo sapiens_hsa007900.59979388
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.59909896
63Toxoplasmosis_Homo sapiens_hsa051450.59665302
64Leishmaniasis_Homo sapiens_hsa051400.59187026
65Pyruvate metabolism_Homo sapiens_hsa006200.59133018
66Chronic myeloid leukemia_Homo sapiens_hsa052200.57551006
67Alcoholism_Homo sapiens_hsa050340.56789261
68Regulation of autophagy_Homo sapiens_hsa041400.56325851
69mTOR signaling pathway_Homo sapiens_hsa041500.55722237
70Allograft rejection_Homo sapiens_hsa053300.55698017
71TNF signaling pathway_Homo sapiens_hsa046680.55624461
72Circadian rhythm_Homo sapiens_hsa047100.54870583
73Prostate cancer_Homo sapiens_hsa052150.54347952
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53777034
75Colorectal cancer_Homo sapiens_hsa052100.53621435
76Bladder cancer_Homo sapiens_hsa052190.52182181
77Pancreatic cancer_Homo sapiens_hsa052120.51641435
78Adherens junction_Homo sapiens_hsa045200.51151000
79Acute myeloid leukemia_Homo sapiens_hsa052210.49152990
80Carbon metabolism_Homo sapiens_hsa012000.49098217
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48266764
82Hippo signaling pathway_Homo sapiens_hsa043900.47840872
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.47047594
84ErbB signaling pathway_Homo sapiens_hsa040120.45794877
85Inositol phosphate metabolism_Homo sapiens_hsa005620.44854858
86Shigellosis_Homo sapiens_hsa051310.44027828
87Renal cell carcinoma_Homo sapiens_hsa052110.43864322
88Osteoclast differentiation_Homo sapiens_hsa043800.43005315
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41819592
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41770948
91Dorso-ventral axis formation_Homo sapiens_hsa043200.38741910
92Prolactin signaling pathway_Homo sapiens_hsa049170.38737612
93Sulfur relay system_Homo sapiens_hsa041220.37608031
94HIF-1 signaling pathway_Homo sapiens_hsa040660.37518892
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37490140
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37286900
97B cell receptor signaling pathway_Homo sapiens_hsa046620.36254939
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36160262
99Pathways in cancer_Homo sapiens_hsa052000.35712243
100Viral myocarditis_Homo sapiens_hsa054160.34410821
101Vitamin digestion and absorption_Homo sapiens_hsa049770.34279210
102N-Glycan biosynthesis_Homo sapiens_hsa005100.33185197
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33011174
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30891918
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30673143
106Lysine degradation_Homo sapiens_hsa003100.30347750
107Biosynthesis of amino acids_Homo sapiens_hsa012300.30128831
108Glioma_Homo sapiens_hsa052140.30112999
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28172287
110Notch signaling pathway_Homo sapiens_hsa043300.27692114
111Malaria_Homo sapiens_hsa051440.26478895
112Non-small cell lung cancer_Homo sapiens_hsa052230.26443254
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26161036
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24664847
115Melanoma_Homo sapiens_hsa052180.23678289
116Hepatitis C_Homo sapiens_hsa051600.23484293
117Propanoate metabolism_Homo sapiens_hsa006400.23001797
118Endometrial cancer_Homo sapiens_hsa052130.22244015
119Wnt signaling pathway_Homo sapiens_hsa043100.22213022
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21407641
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20860639
122Insulin signaling pathway_Homo sapiens_hsa049100.20216496
123Toll-like receptor signaling pathway_Homo sapiens_hsa046200.19941958
124VEGF signaling pathway_Homo sapiens_hsa043700.19510861

Most similar genes based on co-expression Upload to Enrichr

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