TAF1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)4.70907282
2DNA deamination (GO:0045006)4.70601956
3ribosomal small subunit assembly (GO:0000028)4.43678624
4telomere maintenance via semi-conservative replication (GO:0032201)4.33111248
5proteasome assembly (GO:0043248)4.22497375
6DNA strand elongation involved in DNA replication (GO:0006271)4.19810465
7replication fork processing (GO:0031297)4.17294768
8DNA strand elongation (GO:0022616)4.06321708
9intra-S DNA damage checkpoint (GO:0031573)4.04952661
10telomere maintenance via recombination (GO:0000722)3.96978146
11formation of translation preinitiation complex (GO:0001731)3.90806760
12regulation of mitotic spindle checkpoint (GO:1903504)3.88951713
13regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.88951713
14kinetochore organization (GO:0051383)3.88865201
15rRNA modification (GO:0000154)3.84515754
16protein localization to kinetochore (GO:0034501)3.79880904
17rRNA methylation (GO:0031167)3.79098100
18purine nucleobase biosynthetic process (GO:0009113)3.76380515
19regulation of helicase activity (GO:0051095)3.74426701
20negative regulation of DNA-dependent DNA replication (GO:2000104)3.74156289
21CENP-A containing nucleosome assembly (GO:0034080)3.71124278
22DNA replication initiation (GO:0006270)3.70013600
23kinetochore assembly (GO:0051382)3.69393751
24nucleobase biosynthetic process (GO:0046112)3.68393437
25DNA replication checkpoint (GO:0000076)3.66650551
26nucleotide-excision repair, DNA gap filling (GO:0006297)3.65589552
27establishment of protein localization to mitochondrial membrane (GO:0090151)3.64679902
28mitotic recombination (GO:0006312)3.63801420
29chromatin remodeling at centromere (GO:0031055)3.62463213
30metaphase plate congression (GO:0051310)3.62292078
31mitotic metaphase plate congression (GO:0007080)3.57166387
32monoubiquitinated protein deubiquitination (GO:0035520)3.55800876
33regulation of DNA endoreduplication (GO:0032875)3.50619641
34chaperone-mediated protein transport (GO:0072321)3.50605560
35nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.47793438
36DNA replication-independent nucleosome organization (GO:0034724)3.42500554
37DNA replication-independent nucleosome assembly (GO:0006336)3.42500554
38establishment of chromosome localization (GO:0051303)3.39346849
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.37924985
40protein deneddylation (GO:0000338)3.37697564
41transcription-coupled nucleotide-excision repair (GO:0006283)3.37436735
42telomere maintenance via telomere lengthening (GO:0010833)3.36699065
43ribosome assembly (GO:0042255)3.36573984
44centriole replication (GO:0007099)3.36438195
45postreplication repair (GO:0006301)3.35328487
46cullin deneddylation (GO:0010388)3.32214523
47mitotic sister chromatid cohesion (GO:0007064)3.31412840
48resolution of meiotic recombination intermediates (GO:0000712)3.30715261
49recombinational repair (GO:0000725)3.26653948
50double-strand break repair via nonhomologous end joining (GO:0006303)3.25844860
51non-recombinational repair (GO:0000726)3.25844860
52mitotic spindle checkpoint (GO:0071174)3.25162764
53double-strand break repair via homologous recombination (GO:0000724)3.23219808
54ribosome biogenesis (GO:0042254)3.20373229
55histone exchange (GO:0043486)3.17221346
56RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.17139714
57translesion synthesis (GO:0019985)3.16229340
58regulation of nuclear cell cycle DNA replication (GO:0033262)3.15999195
59DNA damage response, detection of DNA damage (GO:0042769)3.14002142
60regulation of centrosome cycle (GO:0046605)3.10805076
61negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.10736529
62IMP biosynthetic process (GO:0006188)3.10343482
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.07083591
64negative regulation of ligase activity (GO:0051352)3.07083591
65peptidyl-histidine modification (GO:0018202)3.06949904
66protein localization to chromosome, centromeric region (GO:0071459)3.05400758
677-methylguanosine mRNA capping (GO:0006370)3.03061837
68histone mRNA metabolic process (GO:0008334)3.02974022
697-methylguanosine RNA capping (GO:0009452)3.01920147
70RNA capping (GO:0036260)3.01920147
71regulation of spindle organization (GO:0090224)3.00485184
72maturation of 5.8S rRNA (GO:0000460)2.98906587
73response to X-ray (GO:0010165)2.98728636
74DNA unwinding involved in DNA replication (GO:0006268)2.97706582
75telomere organization (GO:0032200)2.97651115
76rRNA processing (GO:0006364)2.97396392
77telomere maintenance (GO:0000723)2.97223492
78synapsis (GO:0007129)2.96977405
79regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.93703954
80positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.92661454
81positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.92661454
82positive regulation of mitotic sister chromatid separation (GO:1901970)2.92661454
83DNA double-strand break processing (GO:0000729)2.92490108
84mitochondrial RNA metabolic process (GO:0000959)2.90886771
85spliceosomal snRNP assembly (GO:0000387)2.90784776
86mitotic spindle assembly checkpoint (GO:0007094)2.90687656
87negative regulation of phagocytosis (GO:0050765)2.90590712
88somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.89929014
89somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.89929014
90isotype switching (GO:0045190)2.89929014
91regulation of chromosome segregation (GO:0051983)2.89875743
92spindle assembly checkpoint (GO:0071173)2.89437494
93histone H2A acetylation (GO:0043968)2.88937688
94meiotic chromosome segregation (GO:0045132)2.88935699
95positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.88829419
96regulation of meiosis I (GO:0060631)2.88552089
97termination of RNA polymerase III transcription (GO:0006386)2.88316177
98transcription elongation from RNA polymerase III promoter (GO:0006385)2.88316177
99DNA-dependent DNA replication (GO:0006261)2.88240857
100rRNA metabolic process (GO:0016072)2.88177959
101ribonucleoprotein complex biogenesis (GO:0022613)2.84911171
102negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.84761592
103attachment of spindle microtubules to kinetochore (GO:0008608)2.84395349
104positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.83933251
105mitotic chromosome condensation (GO:0007076)2.83791791
106anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.83104383
107signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.81410386
108DNA ligation (GO:0006266)2.79193332
109regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.76630580
110regulation of centriole replication (GO:0046599)2.75363865
111mitotic sister chromatid segregation (GO:0000070)2.74352848
112positive regulation of chromosome segregation (GO:0051984)2.72911216
113regulation of mitotic metaphase/anaphase transition (GO:0030071)2.72778704
114* transcription elongation from RNA polymerase I promoter (GO:0006362)2.69902526
115DNA catabolic process, exonucleolytic (GO:0000738)2.68547140
116somatic diversification of immune receptors (GO:0002200)2.68546972
117somatic diversification of immunoglobulins (GO:0016445)2.68309598
118somatic cell DNA recombination (GO:0016444)2.68077730
119somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.68077730
120regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.67749875
121somatic recombination of immunoglobulin gene segments (GO:0016447)2.67584974
122negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.67528596
123negative regulation of sister chromatid segregation (GO:0033046)2.67528596
124negative regulation of mitotic sister chromatid separation (GO:2000816)2.67528596
125negative regulation of mitotic sister chromatid segregation (GO:0033048)2.67528596
126maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.67522099
127DNA replication-dependent nucleosome assembly (GO:0006335)2.66748380
128DNA replication-dependent nucleosome organization (GO:0034723)2.66748380
129exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66698544
130G1/S transition of mitotic cell cycle (GO:0000082)2.66498610
131cell cycle G1/S phase transition (GO:0044843)2.66498610
132spindle checkpoint (GO:0031577)2.65145856
133regulation of sister chromatid segregation (GO:0033045)2.64661881
134regulation of mitotic sister chromatid separation (GO:0010965)2.64661881
135regulation of mitotic sister chromatid segregation (GO:0033047)2.64661881
136DNA biosynthetic process (GO:0071897)2.63994548
137positive regulation of mitochondrial fission (GO:0090141)2.63739505
138translational termination (GO:0006415)2.63672165
139sister chromatid segregation (GO:0000819)2.63613485
140regulation of double-strand break repair via homologous recombination (GO:0010569)2.63522676
141nucleotide-excision repair (GO:0006289)2.63283560
142* termination of RNA polymerase I transcription (GO:0006363)2.63169600
143establishment of integrated proviral latency (GO:0075713)2.63064832
144negative regulation of chromosome segregation (GO:0051985)2.62914777
145viral transcription (GO:0019083)2.62836631

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.88080582
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.83524899
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.71272865
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.67551146
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.28061839
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.24329709
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.20818542
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.14378028
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.10328269
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93143552
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.88671581
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.81740881
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.70206893
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.66959811
15VDR_23849224_ChIP-Seq_CD4+_Human2.64917798
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63668613
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.62616485
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.61011935
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59638940
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58696034
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.44910201
22FOXP3_21729870_ChIP-Seq_TREG_Human2.39499561
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.33361163
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.30290104
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29910939
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26131446
27VDR_22108803_ChIP-Seq_LS180_Human2.23300866
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22308170
29ZNF274_21170338_ChIP-Seq_K562_Hela2.17989341
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17974831
31EWS_26573619_Chip-Seq_HEK293_Human2.16194319
32* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.16001450
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13454404
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10501050
35ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08065796
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.04994059
37FUS_26573619_Chip-Seq_HEK293_Human2.01599783
38CIITA_25753668_ChIP-Seq_RAJI_Human1.99187366
39XRN2_22483619_ChIP-Seq_HELA_Human1.94929463
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.92334914
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91828417
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91134714
43ELK1_19687146_ChIP-ChIP_HELA_Human1.88401519
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88002105
45DCP1A_22483619_ChIP-Seq_HELA_Human1.86222034
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84975038
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.84818297
48TTF2_22483619_ChIP-Seq_HELA_Human1.84553495
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83386992
50* GABP_19822575_ChIP-Seq_HepG2_Human1.81421839
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81310328
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.81134012
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80220783
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.78780789
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76225559
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.76001358
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.69614625
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.66029695
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65913852
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64071111
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62654650
62IGF1R_20145208_ChIP-Seq_DFB_Human1.61959119
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.59206129
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58619583
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.53410603
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51518453
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48244398
68P300_19829295_ChIP-Seq_ESCs_Human1.46074067
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45248639
70TAF15_26573619_Chip-Seq_HEK293_Human1.44231722
71* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44124295
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43685501
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.43531298
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41013476
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38954462
76EGR1_19374776_ChIP-ChIP_THP-1_Human1.36877160
77MYC_22102868_ChIP-Seq_BL_Human1.34498595
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34430325
79NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31003399
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30744189
81KDM5A_27292631_Chip-Seq_BREAST_Human1.26389671
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24109182
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23437479
84SPI1_23547873_ChIP-Seq_NB4_Human1.22257717
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22147361
86AR_21909140_ChIP-Seq_LNCAP_Human1.18208565
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.16274875
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.13947370
89MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12955200
90MYC_18940864_ChIP-ChIP_HL60_Human1.11018003
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07847527
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05290993
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05166502
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03157936
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02974471
96GBX2_23144817_ChIP-Seq_PC3_Human1.02546770
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02015773
98ER_23166858_ChIP-Seq_MCF-7_Human1.01992774
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00945753
100IRF8_22096565_ChIP-ChIP_GC-B_Human1.00240839
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.00211695
102PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00069383
103* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99868549
104IRF1_19129219_ChIP-ChIP_H3396_Human0.99652715
105SCL_19346495_ChIP-Seq_HPC-7_Human0.99211444
106CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99131980
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98652568
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97703280
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95851940
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95795183
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95025132
112* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94090340
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93610357
114* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93042011
115* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92331392
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92038516
117CBP_20019798_ChIP-Seq_JUKART_Human0.92038516
118MYB_26560356_Chip-Seq_TH2_Human0.90719760
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90537612
120TP53_22573176_ChIP-Seq_HFKS_Human0.90111491
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90063089
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89815304
123* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89670920
124GATA1_22025678_ChIP-Seq_K562_Human0.89274848
125SOX2_16153702_ChIP-ChIP_HESCs_Human0.88662747
126STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87559032
127CRX_20693478_ChIP-Seq_RETINA_Mouse0.86445848
128ELK1_22589737_ChIP-Seq_MCF10A_Human0.86414223
129SOX2_19829295_ChIP-Seq_ESCs_Human0.86063050
130NANOG_19829295_ChIP-Seq_ESCs_Human0.86063050
131* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85384793
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85255245
133MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.83189372
134FLI1_27457419_Chip-Seq_LIVER_Mouse0.81578900
135CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81465804
136MYB_26560356_Chip-Seq_TH1_Human0.81314173
137STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.80940131
138SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78244458
139BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77501282
140TFEB_21752829_ChIP-Seq_HELA_Human0.74972742
141IRF8_21731497_ChIP-ChIP_J774_Mouse0.73935329
142TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73483645
143CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.70980014
144CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.70837890

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.91018840
2MP0010094_abnormal_chromosome_stability4.47249237
3MP0008057_abnormal_DNA_replication3.84670398
4MP0003077_abnormal_cell_cycle3.62809484
5MP0008877_abnormal_DNA_methylation3.61512832
6MP0004957_abnormal_blastocyst_morpholog3.60810722
7MP0003111_abnormal_nucleus_morphology3.46191380
8MP0008007_abnormal_cellular_replicative3.42511073
9MP0008058_abnormal_DNA_repair3.08961595
10MP0002396_abnormal_hematopoietic_system2.87377528
11MP0003763_abnormal_thymus_physiology2.70106208
12MP0003890_abnormal_embryonic-extraembry2.41993291
13MP0004808_abnormal_hematopoietic_stem2.33333975
14MP0003786_premature_aging2.31694888
15MP0008932_abnormal_embryonic_tissue2.30818835
16MP0009697_abnormal_copulation2.24603087
17MP0006292_abnormal_olfactory_placode2.19595873
18MP0005397_hematopoietic_system_phenotyp2.11072960
19MP0001545_abnormal_hematopoietic_system2.11072960
20MP0006072_abnormal_retinal_apoptosis2.05771777
21MP0005671_abnormal_response_to1.94897586
22MP0002398_abnormal_bone_marrow1.93388622
23MP0001529_abnormal_vocalization1.88188294
24MP0010307_abnormal_tumor_latency1.82629086
25MP0001835_abnormal_antigen_presentation1.81742503
26MP0003123_paternal_imprinting1.72475116
27MP0000703_abnormal_thymus_morphology1.70008417
28MP0003121_genomic_imprinting1.68587598
29MP0008789_abnormal_olfactory_epithelium1.68027457
30MP0003937_abnormal_limbs/digits/tail_de1.62942150
31MP0003941_abnormal_skin_development1.58533230
32MP0001986_abnormal_taste_sensitivity1.57656211
33MP0003195_calcinosis1.57565113
34MP0000372_irregular_coat_pigmentation1.57153902
35MP0000689_abnormal_spleen_morphology1.55115769
36MP0000569_abnormal_digit_pigmentation1.53937936
37MP0003787_abnormal_imprinting1.53392924
38MP0002095_abnormal_skin_pigmentation1.52161731
39MP0003806_abnormal_nucleotide_metabolis1.51949576
40MP0009333_abnormal_splenocyte_physiolog1.48508617
41MP0002722_abnormal_immune_system1.47827273
42MP0002019_abnormal_tumor_incidence1.47047032
43MP0001929_abnormal_gametogenesis1.45680167
44MP0000716_abnormal_immune_system1.45471836
45MP0001800_abnormal_humoral_immune1.45468659
46MP0003567_abnormal_fetal_cardiomyocyte1.42471377
47MP0002420_abnormal_adaptive_immunity1.42415168
48MP0000313_abnormal_cell_death1.41690536
49MP0000015_abnormal_ear_pigmentation1.39366876
50MP0001819_abnormal_immune_cell1.38653947
51MP0000350_abnormal_cell_proliferation1.38648400
52MP0002429_abnormal_blood_cell1.35073859
53MP0001730_embryonic_growth_arrest1.34083299
54MP0005408_hypopigmentation1.34062438
55MP0005253_abnormal_eye_physiology1.32722007
56MP0002938_white_spotting1.32343686
57MP0002210_abnormal_sex_determination1.28569114
58MP0002132_abnormal_respiratory_system1.26689864
59MP0008995_early_reproductive_senescence1.25368109
60MP0002751_abnormal_autonomic_nervous1.24509247
61MP0001984_abnormal_olfaction1.23155304
62MP0000647_abnormal_sebaceous_gland1.20648271
63MP0002452_abnormal_antigen_presenting1.20030630
64MP0002102_abnormal_ear_morphology1.19505263
65MP0009785_altered_susceptibility_to1.18346330
66MP0002233_abnormal_nose_morphology1.17793225
67MP0002723_abnormal_immune_serum1.17182123
68MP0005551_abnormal_eye_electrophysiolog1.16887074
69MP0005084_abnormal_gallbladder_morpholo1.16515331
70MP0003186_abnormal_redox_activity1.16484248
71MP0005394_taste/olfaction_phenotype1.15534920
72MP0005499_abnormal_olfactory_system1.15534920
73MP0005174_abnormal_tail_pigmentation1.15410702
74MP0005075_abnormal_melanosome_morpholog1.14375495
75MP0000490_abnormal_crypts_of1.13967824
76MP0001188_hyperpigmentation1.13400346
77MP0001286_abnormal_eye_development1.09185044
78MP0001697_abnormal_embryo_size1.08551413
79MP0005000_abnormal_immune_tolerance1.07815412
80MP0003943_abnormal_hepatobiliary_system1.07340505
81MP0005646_abnormal_pituitary_gland1.06543924
82MP0000427_abnormal_hair_cycle1.05608555
83MP0001145_abnormal_male_reproductive1.05585480
84MP0001919_abnormal_reproductive_system1.03604874
85MP0002090_abnormal_vision1.03537995
86MP0002085_abnormal_embryonic_tissue1.01967826
87MP0003119_abnormal_digestive_system1.01575240
88MP0003136_yellow_coat_color0.99769894
89MP0002080_prenatal_lethality0.99744331
90MP0005389_reproductive_system_phenotype0.98602685
91MP0002736_abnormal_nociception_after0.98236726
92MP0000653_abnormal_sex_gland0.98042292
93MP0005379_endocrine/exocrine_gland_phen0.97156390
94MP0005395_other_phenotype0.96965455
95MP0002111_abnormal_tail_morphology0.96804922
96MP0005367_renal/urinary_system_phenotyp0.96253481
97MP0000516_abnormal_urinary_system0.96253481
98MP0002254_reproductive_system_inflammat0.95984859
99MP0005391_vision/eye_phenotype0.94584188
100MP0005380_embryogenesis_phenotype0.93551779
101MP0001672_abnormal_embryogenesis/_devel0.93551779
102MP0010030_abnormal_orbit_morphology0.92581035
103MP0002160_abnormal_reproductive_system0.92504349
104MP0003718_maternal_effect0.92242909
105MP0000631_abnormal_neuroendocrine_gland0.91626187
106MP0001324_abnormal_eye_pigmentation0.91405668
107MP0003755_abnormal_palate_morphology0.91170291
108MP0003698_abnormal_male_reproductive0.89971601
109MP0002163_abnormal_gland_morphology0.89743714
110MP0004133_heterotaxia0.89020572
111MP0005025_abnormal_response_to0.88851098
112MP0002166_altered_tumor_susceptibility0.88697320
113MP0001119_abnormal_female_reproductive0.88683524
114MP0004215_abnormal_myocardial_fiber0.87672244
115MP0009379_abnormal_foot_pigmentation0.87540334
116MP0006036_abnormal_mitochondrial_physio0.87254873
117MP0002234_abnormal_pharynx_morphology0.85390754
118MP0000681_abnormal_thyroid_gland0.84234355
119MP0004197_abnormal_fetal_growth/weight/0.84150416
120MP0005645_abnormal_hypothalamus_physiol0.83704291
121MP0001764_abnormal_homeostasis0.83362994
122MP0003122_maternal_imprinting0.81887060
123MP0006054_spinal_hemorrhage0.81092249
124MP0002006_tumorigenesis0.79890270
125MP0000049_abnormal_middle_ear0.79733722
126MP0000685_abnormal_immune_system0.79085539
127MP0004233_abnormal_muscle_weight0.77749903
128MP0000465_gastrointestinal_hemorrhage0.77146273
129MP0006035_abnormal_mitochondrial_morpho0.76752767
130MP0003984_embryonic_growth_retardation0.75943667
131MP0001853_heart_inflammation0.74771062
132MP0003880_abnormal_central_pattern0.73980220
133MP0001485_abnormal_pinna_reflex0.73666295
134MP0002088_abnormal_embryonic_growth/wei0.73456251
135MP0000358_abnormal_cell_content/0.72755194
136MP0005384_cellular_phenotype0.72600184
137MP0009672_abnormal_birth_weight0.72580435
138MP0009703_decreased_birth_body0.72418502
139MP0005410_abnormal_fertilization0.71875556
140MP0002405_respiratory_system_inflammati0.70746362
141MP0002148_abnormal_hypersensitivity_rea0.70719879
142MP0002086_abnormal_extraembryonic_tissu0.69877588
143MP0003315_abnormal_perineum_morphology0.69084131
144MP0003436_decreased_susceptibility_to0.68628887
145MP0001293_anophthalmia0.68438812
146MP0010352_gastrointestinal_tract_polyps0.67568551
147MP0009278_abnormal_bone_marrow0.66579991
148MP0002084_abnormal_developmental_patter0.64589032
149MP0005621_abnormal_cell_physiology0.63509672
150MP0008260_abnormal_autophagy0.62315643

Predicted human phenotypes

RankGene SetZ-score
111 pairs of ribs (HP:0000878)3.79866997
2Aplastic anemia (HP:0001915)3.61598758
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.57900475
4Abnormality of alanine metabolism (HP:0010916)3.57900475
5Hyperalaninemia (HP:0003348)3.57900475
6Chromsome breakage (HP:0040012)3.48199768
7Birth length less than 3rd percentile (HP:0003561)3.44728752
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.36347575
9IgM deficiency (HP:0002850)3.33855972
10Abnormality of chromosome stability (HP:0003220)3.26932536
11Pancreatic cysts (HP:0001737)3.21672461
12Volvulus (HP:0002580)3.14526993
13Reticulocytopenia (HP:0001896)3.09961111
14Abnormality of the preputium (HP:0100587)3.08012997
15Recurrent bronchitis (HP:0002837)3.07532322
16Acute necrotizing encephalopathy (HP:0006965)3.04546662
17Abnormality of DNA repair (HP:0003254)3.03707255
18Meckel diverticulum (HP:0002245)3.03021375
19Abnormal number of erythroid precursors (HP:0012131)2.96508983
20Abnormality of the ileum (HP:0001549)2.89290871
21Aplasia/Hypoplasia of the uvula (HP:0010293)2.84996882
22Abnormality of cells of the erythroid lineage (HP:0012130)2.77344629
23Acute encephalopathy (HP:0006846)2.73662346
24Medulloblastoma (HP:0002885)2.72512672
25Absent thumb (HP:0009777)2.71768592
26Myelodysplasia (HP:0002863)2.71657066
27True hermaphroditism (HP:0010459)2.71451585
28B lymphocytopenia (HP:0010976)2.69529266
29Abnormality of B cell number (HP:0010975)2.69529266
30Progressive macrocephaly (HP:0004481)2.68666117
31Oral leukoplakia (HP:0002745)2.67236305
32Acute lymphatic leukemia (HP:0006721)2.65693566
33Increased CSF lactate (HP:0002490)2.64607929
34Acute myeloid leukemia (HP:0004808)2.59553338
35Bone marrow hypocellularity (HP:0005528)2.55041511
36Abnormal spermatogenesis (HP:0008669)2.55001059
37Type I transferrin isoform profile (HP:0003642)2.54264076
38Type 2 muscle fiber atrophy (HP:0003554)2.54251381
39Mitochondrial inheritance (HP:0001427)2.51940421
40Abnormal mitochondria in muscle tissue (HP:0008316)2.51468037
41Microvesicular hepatic steatosis (HP:0001414)2.51443242
42Ectopic kidney (HP:0000086)2.46334490
43Sloping forehead (HP:0000340)2.45254327
44Abnormal lung lobation (HP:0002101)2.45161862
45IgG deficiency (HP:0004315)2.44897953
46Poikiloderma (HP:0001029)2.41204468
47Increased hepatocellular lipid droplets (HP:0006565)2.38692614
48Squamous cell carcinoma (HP:0002860)2.37728223
49Muscle fiber atrophy (HP:0100295)2.34806397
50Entropion (HP:0000621)2.34782927
51Abnormality of the carotid arteries (HP:0005344)2.33817456
52Patellar aplasia (HP:0006443)2.32141577
53Lymphoma (HP:0002665)2.31643239
54Rough bone trabeculation (HP:0100670)2.29622060
55Agnosia (HP:0010524)2.29529118
56Clubbing of toes (HP:0100760)2.29519082
57Chronic otitis media (HP:0000389)2.29381234
58Duodenal stenosis (HP:0100867)2.29044719
59Small intestinal stenosis (HP:0012848)2.29044719
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.24033371
61Abnormality of methionine metabolism (HP:0010901)2.23960811
62Premature graying of hair (HP:0002216)2.23194080
63Nasal polyposis (HP:0100582)2.22326439
64Aplasia/Hypoplasia of the patella (HP:0006498)2.20177494
65Methylmalonic acidemia (HP:0002912)2.17804109
66Thrombocytosis (HP:0001894)2.17614056
67Bifid tongue (HP:0010297)2.17588529
68Cellular immunodeficiency (HP:0005374)2.16736340
69Gonadotropin excess (HP:0000837)2.16649318
70Lipid accumulation in hepatocytes (HP:0006561)2.14186809
71Abnormality of T cells (HP:0002843)2.13355373
72Nephronophthisis (HP:0000090)2.10437477
73Chronic sinusitis (HP:0011109)2.09851110
74Nephroblastoma (Wilms tumor) (HP:0002667)2.08100242
75Cutaneous melanoma (HP:0012056)2.07482615
76Abnormality of T cell physiology (HP:0011840)2.07222646
77Degeneration of anterior horn cells (HP:0002398)2.07203232
78Abnormality of the anterior horn cell (HP:0006802)2.07203232
79Cleft eyelid (HP:0000625)2.06938854
80Cerebral edema (HP:0002181)2.06406934
81Intestinal atresia (HP:0011100)2.06149266
82Pancreatic fibrosis (HP:0100732)2.03885770
83Colon cancer (HP:0003003)2.03465475
84Pallor (HP:0000980)2.02596627
85Bronchitis (HP:0012387)2.00873764
86Pendular nystagmus (HP:0012043)1.98875850
87Hepatocellular necrosis (HP:0001404)1.98595625
88Aplasia/Hypoplasia of the tibia (HP:0005772)1.98479139
89Pancytopenia (HP:0001876)1.96904056
90Pancreatic islet-cell hyperplasia (HP:0004510)1.96884211
91Thyroiditis (HP:0100646)1.96726581
92Embryonal renal neoplasm (HP:0011794)1.96618228
93Aplasia/Hypoplasia of the thymus (HP:0010515)1.96251525
94Medial flaring of the eyebrow (HP:0010747)1.96086996
95Short tibia (HP:0005736)1.96042359
96Adrenal hypoplasia (HP:0000835)1.95669673
97Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94955425
98Absent radius (HP:0003974)1.94023529
99Panhypogammaglobulinemia (HP:0003139)1.93050008
100Abnormality of the duodenum (HP:0002246)1.92557869
101Exertional dyspnea (HP:0002875)1.92130135
102Basal cell carcinoma (HP:0002671)1.90052606
103Congenital, generalized hypertrichosis (HP:0004540)1.88320607
104Lymphopenia (HP:0001888)1.88083100
105Preaxial hand polydactyly (HP:0001177)1.87868070
106Dandy-Walker malformation (HP:0001305)1.87445342
107Abnormality of the thymus (HP:0000777)1.86239946
108Progressive inability to walk (HP:0002505)1.86093235
109Renal cortical cysts (HP:0000803)1.84083255
110Facial cleft (HP:0002006)1.83965386
111Rhabdomyosarcoma (HP:0002859)1.83937317
112Abnormality of the labia minora (HP:0012880)1.83811738
113Breast hypoplasia (HP:0003187)1.83565713
114Recurrent sinusitis (HP:0011108)1.83085259
115Astigmatism (HP:0000483)1.83017277
116Aplasia involving forearm bones (HP:0009822)1.82583193
117Absent forearm bone (HP:0003953)1.82583193
118Hepatic necrosis (HP:0002605)1.82371396
119Neoplasm of the oral cavity (HP:0100649)1.82230194
120Hypoplastic pelvis (HP:0008839)1.81780812
121Median cleft lip (HP:0000161)1.81330160
122Abnormal respiratory motile cilium morphology (HP:0005938)1.80244115
123Abnormal respiratory epithelium morphology (HP:0012253)1.80244115
124Postaxial foot polydactyly (HP:0001830)1.80143517
125Abnormality of the renal cortex (HP:0011035)1.79434768
126Abnormality of cells of the lymphoid lineage (HP:0012140)1.79259349
1273-Methylglutaconic aciduria (HP:0003535)1.78770483
128Glioma (HP:0009733)1.78722854
129Duplicated collecting system (HP:0000081)1.77716625
130Neoplasm of the adrenal gland (HP:0100631)1.76909861
131Abnormality of the renal medulla (HP:0100957)1.76255397
132Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76097954
133Abolished electroretinogram (ERG) (HP:0000550)1.75584032
134T lymphocytopenia (HP:0005403)1.74899020
135Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.73745906
136Decreased activity of mitochondrial respiratory chain (HP:0008972)1.73745906
137Sclerocornea (HP:0000647)1.73368195
138Chronic hepatic failure (HP:0100626)1.72801701
139Neoplasm of the adrenal cortex (HP:0100641)1.72268477
140Small hand (HP:0200055)1.72006853
141Triphalangeal thumb (HP:0001199)1.71026850
142Molar tooth sign on MRI (HP:0002419)1.69779471
143Abnormality of midbrain morphology (HP:0002418)1.69779471
144Oligohydramnios (HP:0001562)1.69451047
145Severe combined immunodeficiency (HP:0004430)1.69252452
146Prominent nose (HP:0000448)1.69241990
147Lactic acidosis (HP:0003128)1.69115063
148Abnormal hair whorl (HP:0010721)1.68584854
149Genital tract atresia (HP:0001827)1.67543764
150Supernumerary spleens (HP:0009799)1.67370603
151Microretrognathia (HP:0000308)1.67335182
152Increased serum lactate (HP:0002151)1.66762484
153Ependymoma (HP:0002888)1.66756777
154Optic disc pallor (HP:0000543)1.66122030
155Abnormality of the nasal mucosa (HP:0000433)1.65802185
156Anencephaly (HP:0002323)1.65160395
157Oculomotor apraxia (HP:0000657)1.64920003
158Abnormality of serum amino acid levels (HP:0003112)1.62909579
159Hyperglycinemia (HP:0002154)1.62401835
160Congenital primary aphakia (HP:0007707)1.62101164
161Abnormal glycosylation (HP:0012345)1.62088614
162Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.62088614
163Abnormal protein N-linked glycosylation (HP:0012347)1.62088614
164Abnormal protein glycosylation (HP:0012346)1.62088614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK165.74535479
2BUB13.39618622
3TRIM283.35464292
4WEE13.04833649
5BRD42.92832136
6EIF2AK12.81048299
7TSSK62.77031225
8MAP3K122.73905982
9MST42.60866268
10PRPF4B2.49252636
11VRK12.41848658
12MKNK22.41722163
13VRK22.35981421
14PBK2.32103336
15SRPK12.23940777
16ACVR1B2.22743089
17TNIK2.21094248
18TAF12.16821648
19CDC72.14451333
20PLK42.10283659
21BRSK22.10238507
22PNCK2.03852706
23WNK32.01625781
24TLK11.90515625
25MKNK11.89987042
26BMPR1B1.85479446
27CCNB11.84446898
28PLK31.79600985
29ERBB31.79566756
30TXK1.69752096
31NME21.63761859
32NEK21.57281498
33NUAK11.55947375
34MAP4K11.55434291
35PASK1.52065023
36BCR1.48964151
37BRSK11.45207393
38PLK11.44498182
39FRK1.39663878
40PDK31.32282214
41PDK41.32282214
42TEC1.29473396
43PLK21.27588239
44ATR1.27246366
45CDK81.16494550
46TESK21.14792522
47STK38L1.13586818
48EIF2AK31.10414848
49STK31.09678306
50MAP4K21.08287224
51SIK31.04923752
52AURKB1.01268006
53TTK0.98233708
54RPS6KB20.97511001
55CSNK1G10.96817639
56STK240.95392326
57DAPK10.92596914
58DYRK30.91498373
59ZAK0.91222619
60GRK10.87506963
61CHEK20.87399449
62KIT0.86173149
63CSNK1G30.82987638
64NME10.82207549
65MAP3K40.81146731
66TAOK20.78797761
67CSNK1G20.74342630
68EIF2AK20.74100652
69NEK10.73596697
70STK390.72873898
71MAP3K130.72342070
72CDK70.72082016
73ALK0.71137484
74PIM20.69470789
75BRAF0.69131218
76BTK0.68109927
77ADRBK20.67927039
78CSNK1A1L0.66350513
79MUSK0.66236931
80CHEK10.62993771
81IKBKE0.62294516
82SCYL20.62147448
83ZAP700.60803587
84MAP3K140.60745739
85TGFBR10.60089508
86RPS6KA40.59827546
87MAP2K70.59366947
88TESK10.59219473
89DYRK20.58744391
90IKBKB0.58718209
91ATM0.58642455
92IRAK40.58506848
93CDK190.55199199
94ERBB40.55158975
95STK100.55110994
96KDR0.54588090
97RPS6KB10.54315787
98LATS10.54286116
99NLK0.53398852
100EPHA40.51377029
101PRKCE0.49813163
102OXSR10.49511985
103AURKA0.48960627
104CDK40.48691714
105SYK0.48198751
106LCK0.48148950
107STK40.47266146
108CASK0.46456546
109INSRR0.46138193
110FGFR10.46019266
111TNK20.45753652
112CLK10.45251976
113RPS6KA60.44985983
114CSNK2A10.44274104
115MARK30.44234470
116PRKCG0.43986993
117CSNK2A20.42552666
118CDK20.40927455
119BCKDK0.40926273
120RPS6KL10.40849507
121RPS6KC10.40849507
122PDK20.40828967
123LYN0.40742104
124AKT30.38473257
125MAPK130.37621609
126MAPKAPK30.37509835
127CDK30.34654007
128JAK30.33108093
129YES10.32239416
130CDK10.31521462
131CSNK1E0.31063755
132MAP2K30.30480772
133CHUK0.30353996
134MAP3K60.29786543
135MYLK0.29285616
136CDK90.29123582
137RPS6KA50.29096939
138WNK40.28694336
139PRKCI0.26078333
140CSNK1A10.24401320
141PAK30.23890081
142FLT30.22120819
143CSNK1D0.21160064
144MINK10.20437001
145MELK0.20277062
146MAP3K80.19206941
147PRKDC0.18679276

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.67951658
2Mismatch repair_Homo sapiens_hsa034304.02209155
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.25896888
4Base excision repair_Homo sapiens_hsa034103.23520046
5Homologous recombination_Homo sapiens_hsa034403.16602645
6Nucleotide excision repair_Homo sapiens_hsa034203.06175729
7Proteasome_Homo sapiens_hsa030503.02233855
8RNA polymerase_Homo sapiens_hsa030203.01715347
9Ribosome_Homo sapiens_hsa030102.90928717
10Spliceosome_Homo sapiens_hsa030402.71942351
11Fanconi anemia pathway_Homo sapiens_hsa034602.67217188
12Basal transcription factors_Homo sapiens_hsa030222.47779472
13RNA transport_Homo sapiens_hsa030132.43483648
14Cell cycle_Homo sapiens_hsa041102.26885283
15Pyrimidine metabolism_Homo sapiens_hsa002402.23222320
16RNA degradation_Homo sapiens_hsa030182.18853638
17Non-homologous end-joining_Homo sapiens_hsa034502.09172003
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95566052
19Primary immunodeficiency_Homo sapiens_hsa053401.87304219
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87204314
21Propanoate metabolism_Homo sapiens_hsa006401.80781902
22Protein export_Homo sapiens_hsa030601.77212004
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75465285
24Steroid biosynthesis_Homo sapiens_hsa001001.68970105
25p53 signaling pathway_Homo sapiens_hsa041151.48108706
26Purine metabolism_Homo sapiens_hsa002301.38997659
27mRNA surveillance pathway_Homo sapiens_hsa030151.34522340
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32701966
29One carbon pool by folate_Homo sapiens_hsa006701.30443375
30Fatty acid elongation_Homo sapiens_hsa000621.26055471
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23338629
32Epstein-Barr virus infection_Homo sapiens_hsa051691.22558700
33Sulfur metabolism_Homo sapiens_hsa009201.22224490
34Antigen processing and presentation_Homo sapiens_hsa046121.14330297
35Herpes simplex infection_Homo sapiens_hsa051681.09032235
36Oocyte meiosis_Homo sapiens_hsa041141.06474878
37Pyruvate metabolism_Homo sapiens_hsa006201.02015544
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01723344
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01084468
40Intestinal immune network for IgA production_Homo sapiens_hsa046720.99358477
41Phototransduction_Homo sapiens_hsa047440.99146246
42Alzheimers disease_Homo sapiens_hsa050100.91295307
43Measles_Homo sapiens_hsa051620.88181401
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87709863
45Selenocompound metabolism_Homo sapiens_hsa004500.87248701
46Butanoate metabolism_Homo sapiens_hsa006500.85839688
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83247911
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80642825
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75053185
50Sulfur relay system_Homo sapiens_hsa041220.73981892
51T cell receptor signaling pathway_Homo sapiens_hsa046600.71921508
52Vitamin B6 metabolism_Homo sapiens_hsa007500.70869791
53HTLV-I infection_Homo sapiens_hsa051660.68929140
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68909293
55B cell receptor signaling pathway_Homo sapiens_hsa046620.68135515
56Glutathione metabolism_Homo sapiens_hsa004800.67772441
57Huntingtons disease_Homo sapiens_hsa050160.66925356
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66685375
59Pentose phosphate pathway_Homo sapiens_hsa000300.66451333
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65469082
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65406600
62TGF-beta signaling pathway_Homo sapiens_hsa043500.65280965
63Metabolic pathways_Homo sapiens_hsa011000.62826562
64Viral carcinogenesis_Homo sapiens_hsa052030.62594574
65Legionellosis_Homo sapiens_hsa051340.62569406
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.59664059
67Peroxisome_Homo sapiens_hsa041460.59489569
68Parkinsons disease_Homo sapiens_hsa050120.58207593
69Hematopoietic cell lineage_Homo sapiens_hsa046400.56107721
70Hedgehog signaling pathway_Homo sapiens_hsa043400.55583556
71N-Glycan biosynthesis_Homo sapiens_hsa005100.54802445
72Hepatitis B_Homo sapiens_hsa051610.54031567
73Basal cell carcinoma_Homo sapiens_hsa052170.53637305
74Allograft rejection_Homo sapiens_hsa053300.52975021
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51027621
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51012197
77Hippo signaling pathway_Homo sapiens_hsa043900.51006525
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50938560
79Systemic lupus erythematosus_Homo sapiens_hsa053220.50568942
80Tryptophan metabolism_Homo sapiens_hsa003800.50379324
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48948477
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48085482
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.46393097
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46153791
85beta-Alanine metabolism_Homo sapiens_hsa004100.45340268
86Fatty acid metabolism_Homo sapiens_hsa012120.45247266
87Nitrogen metabolism_Homo sapiens_hsa009100.44015297
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43824429
89Leishmaniasis_Homo sapiens_hsa051400.42235383
90Shigellosis_Homo sapiens_hsa051310.42061244
91Ether lipid metabolism_Homo sapiens_hsa005650.41860523
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41785936
93Influenza A_Homo sapiens_hsa051640.41063841
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40675234
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39428709
96Galactose metabolism_Homo sapiens_hsa000520.38616009
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38532923
98Wnt signaling pathway_Homo sapiens_hsa043100.38041387
99Folate biosynthesis_Homo sapiens_hsa007900.37770934
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36984995
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34569215
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34387435
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32709502
104Thyroid cancer_Homo sapiens_hsa052160.32605430
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31798425
106Alcoholism_Homo sapiens_hsa050340.31081512
107Regulation of autophagy_Homo sapiens_hsa041400.29792267
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29516250
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.29165786
110Oxidative phosphorylation_Homo sapiens_hsa001900.28142511
111Olfactory transduction_Homo sapiens_hsa047400.26876094
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.26668600
113Fatty acid degradation_Homo sapiens_hsa000710.26319784
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25223939
115Sphingolipid metabolism_Homo sapiens_hsa006000.24299467
116Linoleic acid metabolism_Homo sapiens_hsa005910.24169701
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24096184
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23822469
119Retinol metabolism_Homo sapiens_hsa008300.23814379
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23783068
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.22808715
122Amphetamine addiction_Homo sapiens_hsa050310.22737085
123Autoimmune thyroid disease_Homo sapiens_hsa053200.22415369
124Long-term potentiation_Homo sapiens_hsa047200.21653632
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20939867
126Lysine degradation_Homo sapiens_hsa003100.20783346
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20632229
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.20415890
129Vitamin digestion and absorption_Homo sapiens_hsa049770.20265470
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20162896
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19786703
132Biosynthesis of amino acids_Homo sapiens_hsa012300.19123282
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18759284
134Apoptosis_Homo sapiens_hsa042100.18645684
135Asthma_Homo sapiens_hsa053100.17998486
136Caffeine metabolism_Homo sapiens_hsa002320.17866869
137Type I diabetes mellitus_Homo sapiens_hsa049400.17207651
138Colorectal cancer_Homo sapiens_hsa052100.16573694
139Non-small cell lung cancer_Homo sapiens_hsa052230.14910214
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14400201
141mTOR signaling pathway_Homo sapiens_hsa041500.14207063
142Carbon metabolism_Homo sapiens_hsa012000.12209644
143Cyanoamino acid metabolism_Homo sapiens_hsa004600.11898237
144Osteoclast differentiation_Homo sapiens_hsa043800.11483547
145Nicotine addiction_Homo sapiens_hsa050330.11386394
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.10648769
147Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.09685440
148Acute myeloid leukemia_Homo sapiens_hsa052210.09372961

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