TAF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.94504761
2mitotic sister chromatid cohesion (GO:0007064)4.74637460
3regulation of histone H3-K27 methylation (GO:0061085)4.42306262
4positive regulation of gamma-delta T cell activation (GO:0046645)4.24483853
5regulation of DNA endoreduplication (GO:0032875)4.09743127
6monoubiquitinated protein deubiquitination (GO:0035520)4.09529473
7histone H3-K4 trimethylation (GO:0080182)4.07378916
8nuclear pore complex assembly (GO:0051292)4.04365993
9nuclear pore organization (GO:0006999)3.62898130
10regulation of gamma-delta T cell differentiation (GO:0045586)3.59743652
11positive regulation of granulocyte differentiation (GO:0030854)3.43951538
12protein dealkylation (GO:0008214)3.41441556
13protein demethylation (GO:0006482)3.41441556
14dosage compensation (GO:0007549)3.38000460
15regulation of gamma-delta T cell activation (GO:0046643)3.37569794
16central nervous system myelination (GO:0022010)3.34419931
17axon ensheathment in central nervous system (GO:0032291)3.34419931
18histone H3-K9 methylation (GO:0051567)3.28389595
19definitive hemopoiesis (GO:0060216)3.25606450
20regulation of RNA export from nucleus (GO:0046831)3.14498725
21histone H3-K9 demethylation (GO:0033169)3.13202257
22cytoplasmic mRNA processing body assembly (GO:0033962)3.11953550
23establishment of protein localization to Golgi (GO:0072600)3.09169710
24negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.09141388
25negative regulation of translation, ncRNA-mediated (GO:0040033)3.09141388
26regulation of translation, ncRNA-mediated (GO:0045974)3.09141388
27peptidyl-lysine trimethylation (GO:0018023)3.07135051
28positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.03186129
29retrograde transport, vesicle recycling within Golgi (GO:0000301)3.02060877
30corticosteroid receptor signaling pathway (GO:0031958)3.00696912
31protein K48-linked deubiquitination (GO:0071108)2.97826377
32positive T cell selection (GO:0043368)2.96020979
33regulation of granulocyte differentiation (GO:0030852)2.93500050
34glucocorticoid receptor signaling pathway (GO:0042921)2.93337622
35* peptidyl-threonine phosphorylation (GO:0018107)2.92843037
36negative regulation of histone methylation (GO:0031061)2.92066339
37histone H3-K4 methylation (GO:0051568)2.91856423
38negative thymic T cell selection (GO:0045060)2.91228018
39histone H3-K9 modification (GO:0061647)2.90149600
40negative T cell selection (GO:0043383)2.87939517
41regulation of centriole replication (GO:0046599)2.87881181
42regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.87264128
43* peptidyl-threonine modification (GO:0018210)2.85843841
44B cell receptor signaling pathway (GO:0050853)2.84584266
45regulation of nucleobase-containing compound transport (GO:0032239)2.83660957
46embryonic hemopoiesis (GO:0035162)2.82972395
47establishment of mitotic spindle localization (GO:0040001)2.82545628
48pore complex assembly (GO:0046931)2.81615806
49negative regulation of DNA-dependent DNA replication (GO:2000104)2.81442719
50establishment of mitotic spindle orientation (GO:0000132)2.81196741
51negative regulation of DNA repair (GO:0045738)2.81125077
52asymmetric protein localization (GO:0008105)2.79997817
53protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.79569419
54cellular response to ethanol (GO:0071361)2.76743662
55sister chromatid cohesion (GO:0007062)2.74506829
56regulation of B cell receptor signaling pathway (GO:0050855)2.73285823
57hypotonic response (GO:0006971)2.72637383
58DNA alkylation (GO:0006305)2.68785892
59DNA methylation (GO:0006306)2.68785892
60regulation of histone H3-K9 methylation (GO:0051570)2.68463654
61insulin-like growth factor receptor signaling pathway (GO:0048009)2.68281796
62mitotic chromosome condensation (GO:0007076)2.67885647
63regulation of NFAT protein import into nucleus (GO:0051532)2.65873157
64mRNA splice site selection (GO:0006376)2.65827292
65embryonic camera-type eye morphogenesis (GO:0048596)2.64962816
66histone H4-K16 acetylation (GO:0043984)2.63102115
67establishment of nucleus localization (GO:0040023)2.62910469
68hepatocyte apoptotic process (GO:0097284)2.62537536
69positive regulation of histone H3-K4 methylation (GO:0051571)2.61949906
70negative regulation of myotube differentiation (GO:0010832)2.61260129
71regulation of histone H3-K4 methylation (GO:0051569)2.60538848
72regulation of histone methylation (GO:0031060)2.60260116
73histone lysine demethylation (GO:0070076)2.59819990
74T cell selection (GO:0045058)2.58650726
75regulation of establishment of cell polarity (GO:2000114)2.56826000
76kinetochore organization (GO:0051383)2.55408281
77stress granule assembly (GO:0034063)2.55048847
78histone H3-K36 demethylation (GO:0070544)2.54846941
79histone lysine methylation (GO:0034968)2.54146371
80sister chromatid segregation (GO:0000819)2.53881848
81pre-miRNA processing (GO:0031054)2.53091674
82striated muscle atrophy (GO:0014891)2.51980484
83N-terminal protein amino acid acetylation (GO:0006474)2.51019608
84apical protein localization (GO:0045176)2.50342189
85myelination (GO:0042552)2.49156477
86negative regulation of neurotransmitter secretion (GO:0046929)2.48939447
87negative regulation of erythrocyte differentiation (GO:0045647)2.48264495
88phospholipid translocation (GO:0045332)2.48138318
89lipid translocation (GO:0034204)2.48138318
90DNA methylation involved in gamete generation (GO:0043046)2.47964429
91negative regulation of granulocyte differentiation (GO:0030853)2.47152073
92interkinetic nuclear migration (GO:0022027)2.46748934
93ensheathment of neurons (GO:0007272)2.46193755
94axon ensheathment (GO:0008366)2.46193755
95coronary vasculature morphogenesis (GO:0060977)2.46041750
96regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.45898312
97response to epidermal growth factor (GO:0070849)2.45861812
98regulation of gene expression by genetic imprinting (GO:0006349)2.45496302
99DNA topological change (GO:0006265)2.45194328
100centrosome localization (GO:0051642)2.45032999
101histone demethylation (GO:0016577)2.44896144
102positive thymic T cell selection (GO:0045059)2.44642841
103peptidyl-lysine dimethylation (GO:0018027)2.44641477
104thymic T cell selection (GO:0045061)2.43878505
105activated T cell proliferation (GO:0050798)2.43715172
106iron ion import (GO:0097286)2.43079738
107negative regulation of chromatin modification (GO:1903309)2.41191755
108histone deubiquitination (GO:0016578)2.40497007
109genetic imprinting (GO:0071514)2.40037722
110positive regulation of developmental pigmentation (GO:0048087)2.40023741
111establishment of spindle localization (GO:0051293)2.39565955
112regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.38769780
113positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.38769780
114negative regulation of neurotransmitter transport (GO:0051589)2.38526463
115regulation of meiosis I (GO:0060631)2.37449353
116pericardium development (GO:0060039)2.36957962
117regulation of sister chromatid cohesion (GO:0007063)2.36772842
118chromatin assembly (GO:0031497)2.36684713
119establishment of spindle orientation (GO:0051294)2.35615786
120positive regulation of mRNA catabolic process (GO:0061014)2.35461626
121neuron cell-cell adhesion (GO:0007158)2.34106801
122DNA unwinding involved in DNA replication (GO:0006268)2.34081460
123TOR signaling (GO:0031929)2.33999541
124peptidyl-lysine methylation (GO:0018022)2.33536089
125spindle assembly involved in mitosis (GO:0090307)2.31960627
126negative regulation of organelle assembly (GO:1902116)2.31634397
127embryonic process involved in female pregnancy (GO:0060136)2.31430052
128negative regulation of T cell mediated immunity (GO:0002710)2.30945820
129positive regulation by host of viral transcription (GO:0043923)2.30858475
130layer formation in cerebral cortex (GO:0021819)2.30604604
131neuron recognition (GO:0008038)2.29377153
132nucleus localization (GO:0051647)2.27095127
133regulation of protein polyubiquitination (GO:1902914)2.25498076
134positive regulation of mRNA processing (GO:0050685)2.23855965
135regulation of mRNA 3-end processing (GO:0031440)2.22621656
136dendrite morphogenesis (GO:0048813)2.20937917
137transmission of nerve impulse (GO:0019226)2.20550570
138L-amino acid import (GO:0043092)2.17744443
139cerebellar Purkinje cell differentiation (GO:0021702)2.17308112
140histone methylation (GO:0016571)2.17150880
141meiotic chromosome segregation (GO:0045132)2.16451083
142centrosome duplication (GO:0051298)2.15750541
143presynaptic membrane assembly (GO:0097105)2.15707957
144microtubule anchoring (GO:0034453)2.15677067
145positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.15356963
146regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.15356963
147axonal fasciculation (GO:0007413)2.15165692
148mitotic cytokinesis (GO:0000281)2.13845688
149positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.12937183
150positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.12937183
151positive regulation of mitotic sister chromatid separation (GO:1901970)2.12937183
152regulation of DNA methylation (GO:0044030)2.12440283
153heterochromatin organization (GO:0070828)2.12309421
154eye photoreceptor cell differentiation (GO:0001754)2.11250532
155photoreceptor cell differentiation (GO:0046530)2.11250532
156protein targeting to Golgi (GO:0000042)2.10771788
157positive regulation of histone methylation (GO:0031062)2.09957257
158nerve growth factor signaling pathway (GO:0038180)2.09161430
159regulation of short-term neuronal synaptic plasticity (GO:0048172)2.08804007
160male sex determination (GO:0030238)2.08772675
161negative regulation of histone modification (GO:0031057)2.06213694
162neuronal stem cell maintenance (GO:0097150)2.05751431
163positive regulation of meiosis (GO:0045836)2.05660071

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.86352780
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.45748660
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.15283614
4EZH2_22144423_ChIP-Seq_EOC_Human2.99877825
5GBX2_23144817_ChIP-Seq_PC3_Human2.97448900
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.94340656
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.90994914
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.69578382
9GATA1_22025678_ChIP-Seq_K562_Human2.66260897
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.64475935
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.46950046
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.32982027
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.31139921
14SCL_19346495_ChIP-Seq_HPC-7_Human2.28140771
15MYC_22102868_ChIP-Seq_BL_Human2.08111584
16FUS_26573619_Chip-Seq_HEK293_Human2.07504576
17RUNX_20019798_ChIP-Seq_JUKART_Human2.06307180
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.04200379
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03544654
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03175339
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.97530553
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96658060
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95838654
24TP53_16413492_ChIP-PET_HCT116_Human1.92322464
25* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.90445092
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.83161694
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.79686746
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79640039
29EWS_26573619_Chip-Seq_HEK293_Human1.75975024
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.75339351
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.74091725
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.73625076
33DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.69834070
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66620416
35TCF7_22412390_ChIP-Seq_EML_Mouse1.60057459
36TAF15_26573619_Chip-Seq_HEK293_Human1.59270450
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58598289
38MYB_26560356_Chip-Seq_TH1_Human1.57497771
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55308109
40STAT3_23295773_ChIP-Seq_U87_Human1.55278676
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.54152368
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53788643
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53607412
44KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.53540384
45KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.53540384
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.53540384
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52747973
48MYB_26560356_Chip-Seq_TH2_Human1.52734259
49GATA1_19941826_ChIP-Seq_K562_Human1.52574109
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49589243
51* SMAD4_21799915_ChIP-Seq_A2780_Human1.49169965
52SPI1_23127762_ChIP-Seq_K562_Human1.48327552
53AR_21572438_ChIP-Seq_LNCaP_Human1.46736019
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43660310
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43511230
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.43319007
57TCF4_23295773_ChIP-Seq_U87_Human1.43045104
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41769700
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41260962
60GATA2_19941826_ChIP-Seq_K562_Human1.39313980
61P300_19829295_ChIP-Seq_ESCs_Human1.36615005
62SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35577962
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.35175210
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35141479
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33666737
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33461613
67IGF1R_20145208_ChIP-Seq_DFB_Human1.33453045
68FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.30498864
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.30344548
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29883453
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29441200
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28571799
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.28496523
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28285658
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27042292
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26952197
77ER_23166858_ChIP-Seq_MCF-7_Human1.26729580
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25972339
79FOXA2_19822575_ChIP-Seq_HepG2_Human1.24874231
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.24610512
81DROSHA_22980978_ChIP-Seq_HELA_Human1.24260488
82PKCTHETA_26484144_Chip-Seq_BREAST_Human1.23908720
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.22206850
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20474493
85STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20223889
86JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19780554
87KDM2B_26808549_Chip-Seq_DND41_Human1.19601333
88ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19297958
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19219063
90* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18900241
91EGR1_19374776_ChIP-ChIP_THP-1_Human1.17928732
92MAF_26560356_Chip-Seq_TH1_Human1.17909804
93SOX2_21211035_ChIP-Seq_LN229_Gbm1.17871314
94AHR_22903824_ChIP-Seq_MCF-7_Human1.17759919
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17300332
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16718169
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15933621
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.15920470
99NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15801760
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15554299
101SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14404391
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14366263
103GATA1_19941827_ChIP-Seq_MEL_Mouse1.14295244
104SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13834160
105VDR_24787735_ChIP-Seq_THP-1_Human1.13698252
106VDR_21846776_ChIP-Seq_THP-1_Human1.13512864
107RNF2_27304074_Chip-Seq_NSC_Mouse1.13176834
108KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12550637
109* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12173869
110CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11133936
111PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11051574
112E2F1_18555785_Chip-Seq_ESCs_Mouse1.10732140
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10242117
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10178616
115GATA3_27048872_Chip-Seq_THYMUS_Human1.08544550
116CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07084511
117EZH2_27304074_Chip-Seq_ESCs_Mouse1.06193446
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05311211
119ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04601624
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03672217
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03338174
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02894305
123CMYC_18555785_Chip-Seq_ESCs_Mouse1.02812582
124NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02642348
125CHD1_26751641_Chip-Seq_LNCaP_Human1.02232463
126RUNX2_22187159_ChIP-Seq_PCA_Human1.01312336
127TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01305325
128ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01056442
129FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99843014
130TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99463309
131PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99161837
132RUNX1_27514584_Chip-Seq_MCF-7_Human0.99095322
133RNF2_27304074_Chip-Seq_ESCs_Mouse0.99090216
134POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98729632
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98729632
136FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98628913
137TP63_19390658_ChIP-ChIP_HaCaT_Human0.98500673
138SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97959150
139RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97878037
140EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97878037
141VDR_24763502_ChIP-Seq_THP-1_Human0.97392964
142CIITA_25753668_ChIP-Seq_RAJI_Human0.97159601
143RXR_22108803_ChIP-Seq_LS180_Human0.96510861
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96473110
145GATA2_21666600_ChIP-Seq_HMVEC_Human0.96352883
146IRF8_27001747_Chip-Seq_BMDM_Mouse0.96315992
147ISL1_27105846_Chip-Seq_CPCs_Mouse0.96219198
148RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95976703
149SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95882645
150SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94298353
151TCF4_18268006_ChIP-ChIP_LS174T_Human0.93449978
152RING1B_27294783_Chip-Seq_NPCs_Mouse0.93225372
153CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93147830
154RARB_27405468_Chip-Seq_BRAIN_Mouse0.93138623
155EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92448929
156NCOR1_26117541_ChIP-Seq_K562_Human0.92011429
157TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91693038
158IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91476355
159PU_27001747_Chip-Seq_BMDM_Mouse0.89848241

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.33956389
2MP0003787_abnormal_imprinting3.89923747
3MP0008877_abnormal_DNA_methylation3.85526959
4MP0003950_abnormal_plasma_membrane3.11074127
5MP0003763_abnormal_thymus_physiology2.97656811
6MP0002166_altered_tumor_susceptibility2.93528722
7MP0003121_genomic_imprinting2.78104337
8MP0002396_abnormal_hematopoietic_system2.77176483
9MP0008057_abnormal_DNA_replication2.69717322
10MP0004808_abnormal_hematopoietic_stem2.49158238
11MP0005171_absent_coat_pigmentation2.33922154
12MP0009780_abnormal_chondrocyte_physiolo2.21535592
13MP0004381_abnormal_hair_follicle2.11966530
14MP0003880_abnormal_central_pattern2.08392083
15MP0004859_abnormal_synaptic_plasticity1.92256644
16MP0003656_abnormal_erythrocyte_physiolo1.88867010
17MP0003123_paternal_imprinting1.86096607
18MP0002006_tumorigenesis1.80785752
19MP0000778_abnormal_nervous_system1.79182712
20MP0010094_abnormal_chromosome_stability1.78401039
21MP0001188_hyperpigmentation1.71177946
22MP0000703_abnormal_thymus_morphology1.70755830
23MP0003828_pulmonary_edema1.63569949
24MP0003937_abnormal_limbs/digits/tail_de1.61580154
25MP0005451_abnormal_body_composition1.59730825
26MP0005623_abnormal_meninges_morphology1.59398695
27MP0002009_preneoplasia1.59367239
28MP0003890_abnormal_embryonic-extraembry1.57647084
29MP0004130_abnormal_muscle_cell1.56320393
30MP0003984_embryonic_growth_retardation1.54607849
31MP0006072_abnormal_retinal_apoptosis1.52399497
32MP0003111_abnormal_nucleus_morphology1.51789394
33MP0002088_abnormal_embryonic_growth/wei1.51541205
34MP0003705_abnormal_hypodermis_morpholog1.49817640
35MP0004885_abnormal_endolymph1.48839572
36MP0004270_analgesia1.47978634
37MP0003221_abnormal_cardiomyocyte_apopto1.44242454
38MP0001299_abnormal_eye_distance/1.43253590
39MP0003122_maternal_imprinting1.40791553
40MP0002086_abnormal_extraembryonic_tissu1.38498743
41MP0004264_abnormal_extraembryonic_tissu1.36889014
42MP0002398_abnormal_bone_marrow1.34714975
43MP0000920_abnormal_myelination1.34649604
44MP0009278_abnormal_bone_marrow1.32465657
45MP0005423_abnormal_somatic_nervous1.32408045
46MP0002877_abnormal_melanocyte_morpholog1.31197507
47MP0000631_abnormal_neuroendocrine_gland1.30614838
48MP0009115_abnormal_fat_cell1.30354540
49MP0005380_embryogenesis_phenotype1.29890428
50MP0001672_abnormal_embryogenesis/_devel1.29890428
51MP0009703_decreased_birth_body1.29615035
52MP0003635_abnormal_synaptic_transmissio1.25802542
53MP0001486_abnormal_startle_reflex1.25423622
54MP0004185_abnormal_adipocyte_glucose1.24870402
55MP0003045_fibrosis1.23629365
56MP0001800_abnormal_humoral_immune1.20226661
57MP0004084_abnormal_cardiac_muscle1.18004028
58MP0003861_abnormal_nervous_system1.16635045
59MP0005409_darkened_coat_color1.16617474
60MP0001835_abnormal_antigen_presentation1.15635085
61MP0005076_abnormal_cell_differentiation1.14567539
62MP0000955_abnormal_spinal_cord1.14342795
63MP0010678_abnormal_skin_adnexa1.13424139
64MP0001545_abnormal_hematopoietic_system1.12772246
65MP0005397_hematopoietic_system_phenotyp1.12772246
66MP0004742_abnormal_vestibular_system1.12221059
67MP0010630_abnormal_cardiac_muscle1.12063789
68MP0010307_abnormal_tumor_latency1.11734664
69MP0003077_abnormal_cell_cycle1.11086234
70MP0000015_abnormal_ear_pigmentation1.10625634
71MP0002084_abnormal_developmental_patter1.09312472
72MP0002063_abnormal_learning/memory/cond1.08625794
73MP0005621_abnormal_cell_physiology1.07624650
74MP0002722_abnormal_immune_system1.07533160
75MP0002925_abnormal_cardiovascular_devel1.07473094
76MP0003183_abnormal_peptide_metabolism1.06284504
77MP0008995_early_reproductive_senescence1.05984918
78MP0001915_intracranial_hemorrhage1.04108245
79MP0000537_abnormal_urethra_morphology1.03892524
80MP0003935_abnormal_craniofacial_develop1.02833915
81MP0003755_abnormal_palate_morphology1.02576341
82MP0003091_abnormal_cell_migration1.01067074
83MP0004036_abnormal_muscle_relaxation1.00512036
84MP0010352_gastrointestinal_tract_polyps1.00241763
85MP0000427_abnormal_hair_cycle0.98905861
86MP0008058_abnormal_DNA_repair0.98130901
87MP0003943_abnormal_hepatobiliary_system0.97700010
88MP0005253_abnormal_eye_physiology0.97452448
89MP0001730_embryonic_growth_arrest0.97303581
90MP0003115_abnormal_respiratory_system0.97285238
91MP0001485_abnormal_pinna_reflex0.96962278
92MP0000428_abnormal_craniofacial_morphol0.96906254
93MP0005551_abnormal_eye_electrophysiolog0.96852251
94MP0000383_abnormal_hair_follicle0.96455395
95MP0000685_abnormal_immune_system0.96020244
96MP0000462_abnormal_digestive_system0.95982938
97MP0004197_abnormal_fetal_growth/weight/0.95835647
98MP0000689_abnormal_spleen_morphology0.95562363
99MP0003941_abnormal_skin_development0.95533984
100MP0001697_abnormal_embryo_size0.95251441
101MP0003385_abnormal_body_wall0.94933546
102MP0002152_abnormal_brain_morphology0.94755794
103MP0004233_abnormal_muscle_weight0.94578647
104MP0005645_abnormal_hypothalamus_physiol0.94504734
105MP0002108_abnormal_muscle_morphology0.94477645
106MP0001177_atelectasis0.94471097
107MP0002882_abnormal_neuron_morphology0.94354585
108MP0002184_abnormal_innervation0.93625945
109MP0004134_abnormal_chest_morphology0.92975104
110MP0005174_abnormal_tail_pigmentation0.92568606
111MP0002572_abnormal_emotion/affect_behav0.91089204
112MP0000432_abnormal_head_morphology0.89460154
113MP0009745_abnormal_behavioral_response0.89142212
114MP0005367_renal/urinary_system_phenotyp0.87484693
115MP0000516_abnormal_urinary_system0.87484693
116MP0003632_abnormal_nervous_system0.87211426
117MP0005187_abnormal_penis_morphology0.87150484
118MP0002751_abnormal_autonomic_nervous0.86955213
119MP0002405_respiratory_system_inflammati0.86836873
120MP0000716_abnormal_immune_system0.86834722
121MP0006292_abnormal_olfactory_placode0.86766074
122MP0003283_abnormal_digestive_organ0.86629886
123MP0002272_abnormal_nervous_system0.86508419
124MP0000350_abnormal_cell_proliferation0.86129605
125MP0001784_abnormal_fluid_regulation0.85655715
126MP0002085_abnormal_embryonic_tissue0.85553062
127MP0003634_abnormal_glial_cell0.85221607
128MP0000733_abnormal_muscle_development0.84247022
129MP0003690_abnormal_glial_cell0.83758257
130MP0002557_abnormal_social/conspecific_i0.81438673
131MP0000266_abnormal_heart_morphology0.81190844
132MP0005391_vision/eye_phenotype0.81109061
133MP0002420_abnormal_adaptive_immunity0.80582469
134MP0003300_gastrointestinal_ulcer0.79977792
135MP0002064_seizures0.79932176
136MP0001346_abnormal_lacrimal_gland0.79870056
137MP0001293_anophthalmia0.79384975
138MP0002177_abnormal_outer_ear0.78795922
139MP0000534_abnormal_ureter_morphology0.78734464
140MP0003938_abnormal_ear_development0.78550518
141MP0008961_abnormal_basal_metabolism0.78442221
142MP0001348_abnormal_lacrimal_gland0.78265012
143MP0001819_abnormal_immune_cell0.77990100
144MP0003866_abnormal_defecation0.77909051
145MP0001286_abnormal_eye_development0.76843471
146MP0004947_skin_inflammation0.76390919
147MP0002080_prenatal_lethality0.76125047
148MP0002116_abnormal_craniofacial_bone0.75632421
149MP0001440_abnormal_grooming_behavior0.74580338
150MP0004087_abnormal_muscle_fiber0.74569107
151MP0008260_abnormal_autophagy0.74219791
152MP0002429_abnormal_blood_cell0.73965658
153MP0005646_abnormal_pituitary_gland0.73647803
154MP0003136_yellow_coat_color0.73644260
155MP0005384_cellular_phenotype0.72318258
156MP0002067_abnormal_sensory_capabilities0.72227364
157MP0002081_perinatal_lethality0.72087428
158MP0002210_abnormal_sex_determination0.71260580
159MP0004883_abnormal_blood_vessel0.71000970
160MP0000371_diluted_coat_color0.70312068
161MP0001661_extended_life_span0.70266498
162MP0004484_altered_response_of0.69782559
163MP0002752_abnormal_somatic_nervous0.69637289
164MP0002019_abnormal_tumor_incidence0.68225893
165MP0000377_abnormal_hair_follicle0.67453329
166MP0010234_abnormal_vibrissa_follicle0.67158523
167MP0003959_abnormal_lean_body0.66787043

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.44010712
2Acute myeloid leukemia (HP:0004808)3.13246312
3Macroorchidism (HP:0000053)3.08739785
4Sandal gap (HP:0001852)2.83182322
5Dysmetric saccades (HP:0000641)2.78157711
6Aqueductal stenosis (HP:0002410)2.67902610
7Subacute progressive viral hepatitis (HP:0006572)2.67680142
8Oligodactyly (hands) (HP:0001180)2.56460276
9Acute lymphatic leukemia (HP:0006721)2.51345671
10Deep palmar crease (HP:0006191)2.41031304
11Chromsome breakage (HP:0040012)2.40459766
12Relative macrocephaly (HP:0004482)2.40232408
13Dislocated radial head (HP:0003083)2.37540825
14T lymphocytopenia (HP:0005403)2.35632256
15Prominent nose (HP:0000448)2.35354232
16Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.35099722
17Degeneration of the lateral corticospinal tracts (HP:0002314)2.35099722
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.34716213
19Abnormality of the astrocytes (HP:0100707)2.32796546
20Astrocytoma (HP:0009592)2.32796546
21Truncal obesity (HP:0001956)2.30474200
22Abnormality of the labia minora (HP:0012880)2.30070647
23Colitis (HP:0002583)2.29959741
24Germ cell neoplasia (HP:0100728)2.27314091
25Obsessive-compulsive behavior (HP:0000722)2.26678983
26Abnormality of the radial head (HP:0003995)2.25434346
27Abnormality of the columella (HP:0009929)2.22512059
28* Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.20929128
29Increased nuchal translucency (HP:0010880)2.20472461
30Abnormality of the fingertips (HP:0001211)2.19720835
31Abnormality of the corticospinal tract (HP:0002492)2.18045899
32Abnormality of the nasal septum (HP:0000419)2.17133272
33Low anterior hairline (HP:0000294)2.16595741
34Chin dimple (HP:0010751)2.12490423
35Anteriorly placed anus (HP:0001545)2.09123749
36Heterotopia (HP:0002282)2.06492044
37Absent frontal sinuses (HP:0002688)2.05811665
38Protruding tongue (HP:0010808)2.05520732
39Viral hepatitis (HP:0006562)2.05042481
40Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.04229550
41Ectopic kidney (HP:0000086)2.04125447
42Abnormality of T cell number (HP:0011839)2.03191071
43Thick eyebrow (HP:0000574)2.02144310
44Overgrowth (HP:0001548)2.01897074
45Neonatal hypoglycemia (HP:0001998)2.01439967
46Short chin (HP:0000331)2.01183824
47Overriding aorta (HP:0002623)2.00919043
48Cystic hygroma (HP:0000476)2.00360761
49Ankyloglossia (HP:0010296)2.00318988
50Vertebral arch anomaly (HP:0008438)2.00305511
51Genetic anticipation (HP:0003743)1.99997985
52Curly hair (HP:0002212)1.99962466
53Glioma (HP:0009733)1.99377796
54Termporal pattern (HP:0011008)1.97810644
55Insidious onset (HP:0003587)1.97810644
56Cubitus valgus (HP:0002967)1.96763741
57Spinal cord lesions (HP:0100561)1.96691809
58Syringomyelia (HP:0003396)1.96691809
59Capillary hemangiomas (HP:0005306)1.96275502
60Aortic aneurysm (HP:0004942)1.93941614
61Supernumerary ribs (HP:0005815)1.90623121
62Limited elbow extension (HP:0001377)1.90126946
63Abnormality of chromosome segregation (HP:0002916)1.89149219
64Persistence of primary teeth (HP:0006335)1.87177088
65High anterior hairline (HP:0009890)1.86326188
66Large earlobe (HP:0009748)1.86035209
67Drooling (HP:0002307)1.84412794
68Excessive salivation (HP:0003781)1.84412794
69Spontaneous hematomas (HP:0007420)1.83437795
70Mitral valve prolapse (HP:0001634)1.83319266
71Coarse hair (HP:0002208)1.82831758
72Abnormality of chromosome stability (HP:0003220)1.81980089
73Abnormality of incisor morphology (HP:0011063)1.80823169
74Proximal placement of thumb (HP:0009623)1.80137934
75Aplasia cutis congenita (HP:0001057)1.79105884
76Esophageal atresia (HP:0002032)1.77002525
77Abnormality of the antihelix (HP:0009738)1.76564390
78Abnormality of the ischium (HP:0003174)1.76154974
79Widely spaced teeth (HP:0000687)1.76113629
80Duplicated collecting system (HP:0000081)1.75893666
81Cafe-au-lait spot (HP:0000957)1.75748480
82Gastroesophageal reflux (HP:0002020)1.74877140
83Intellectual disability, moderate (HP:0002342)1.74556972
84Narrow palate (HP:0000189)1.72227320
85Impaired smooth pursuit (HP:0007772)1.71926397
86Ependymoma (HP:0002888)1.71207450
87Deviation of the thumb (HP:0009603)1.70883581
88Abnormal auditory evoked potentials (HP:0006958)1.70848207
89Papillary thyroid carcinoma (HP:0002895)1.70766763
90Bladder carcinoma (HP:0002862)1.70505591
91Bladder neoplasm (HP:0009725)1.70505591
92Abnormality of oral frenula (HP:0000190)1.68985160
93Supernumerary bones of the axial skeleton (HP:0009144)1.68554461
94Abnormal hair whorl (HP:0010721)1.67205438
95Deep philtrum (HP:0002002)1.67043925
96Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.66373255
97Short 4th metacarpal (HP:0010044)1.66373255
98Abnormality of the renal collecting system (HP:0004742)1.65872087
99Hyperkalemia (HP:0002153)1.65663553
100Oligodactyly (HP:0012165)1.64325173
101Long eyelashes (HP:0000527)1.63322990
102Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.63178119
103Abnormality of DNA repair (HP:0003254)1.62128193
104Trigonocephaly (HP:0000243)1.61274444
105Broad palm (HP:0001169)1.61257630
106Elfin facies (HP:0004428)1.60874023
107Arterial tortuosity (HP:0005116)1.60788561
108Midline defect of the nose (HP:0004122)1.60587054
109Vesicoureteral reflux (HP:0000076)1.60284495
110Abnormality of the distal phalanx of the thumb (HP:0009617)1.59140762
111Thyroid carcinoma (HP:0002890)1.59061760
112Tapered finger (HP:0001182)1.58917378
113Bicuspid aortic valve (HP:0001647)1.58827020
114Progressive cerebellar ataxia (HP:0002073)1.58734839
115Papilledema (HP:0001085)1.58664779
116Wide intermamillary distance (HP:0006610)1.58275307
117Hypoplasia of the maxilla (HP:0000327)1.58156820
118Cutis marmorata (HP:0000965)1.57763580
119Renovascular hypertension (HP:0100817)1.57748525
120Bowel incontinence (HP:0002607)1.57178300
121Abnormality of the incisor (HP:0000676)1.56987885
122Action tremor (HP:0002345)1.56926357
123Cupped ear (HP:0000378)1.56824603
124Hypoplastic ischia (HP:0003175)1.56527681
125Neoplasm of the oral cavity (HP:0100649)1.56082089
126Hyperacusis (HP:0010780)1.55690291
127Insomnia (HP:0100785)1.55180674
128Broad face (HP:0000283)1.55032769
129Decreased lacrimation (HP:0000633)1.54816370
130Hypopigmentation of the fundus (HP:0007894)1.54371025
131Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.54352177
132Sparse lateral eyebrow (HP:0005338)1.54261003
133Eczematoid dermatitis (HP:0000976)1.54032633
134Difficulty running (HP:0009046)1.53336899
135Gastrointestinal carcinoma (HP:0002672)1.52771449
136Malignant gastrointestinal tract tumors (HP:0006749)1.52771449
137Leiomyosarcoma (HP:0100243)1.52508491
138Uterine leiomyosarcoma (HP:0002891)1.52508491
139Hypoplastic labia majora (HP:0000059)1.52073619
140Inappropriate behavior (HP:0000719)1.51980021
141Abnormality of the epiphyses of the hand (HP:0005924)1.51865820
142Transitional cell carcinoma of the bladder (HP:0006740)1.51295377
143Absent forearm bone (HP:0003953)1.51166465
144Aplasia involving forearm bones (HP:0009822)1.51166465
145Fair hair (HP:0002286)1.50725312
146Hypoplastic pelvis (HP:0008839)1.50500274
147Abnormality of the thoracic spine (HP:0100711)1.50307016
148Recurrent viral infections (HP:0004429)1.50298244
149Abnormality of salivation (HP:0100755)1.49444521
150Inflammation of the large intestine (HP:0002037)1.49099209
151Absent radius (HP:0003974)1.49006256
152Abnormal delayed hypersensitivity skin test (HP:0002963)1.48871826
153Medulloblastoma (HP:0002885)1.48291540
154Absent speech (HP:0001344)1.48093472
155Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.47965984
156Somatic mutation (HP:0001428)1.47728149
157Urinary bladder sphincter dysfunction (HP:0002839)1.46917656
158Abnormality of the frontal sinuses (HP:0002687)1.46772937
159Broad thumb (HP:0011304)1.46579978
160Abnormality of ocular smooth pursuit (HP:0000617)1.46473280
161Exotropia (HP:0000577)1.44330677
162Anal stenosis (HP:0002025)1.43743369
163Alacrima (HP:0000522)1.42545678
164Nephroblastoma (Wilms tumor) (HP:0002667)1.42520373
165Dysdiadochokinesis (HP:0002075)1.41883575
166Stomach cancer (HP:0012126)1.41193327
167Dysmetria (HP:0001310)1.40516234
168Lip pit (HP:0100267)1.40345245
169Macrotia (HP:0000400)1.40243718
170Abnormality of the carotid arteries (HP:0005344)1.39266158
171Flat cornea (HP:0007720)1.39145804
172Focal seizures (HP:0007359)1.39018041
173Small hand (HP:0200055)1.38405592
174Skull defect (HP:0001362)1.38255483
175Scanning speech (HP:0002168)1.37521896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.43577594
2PNCK2.81652074
3BRD42.79793201
4EEF2K2.63936643
5CDC72.51909350
6MAP3K102.36945910
7AKT32.36134387
8STK392.13459049
9INSRR1.99244817
10TRIB31.99032363
11NTRK31.92040313
12CAMK1G1.79127460
13FGFR21.75507497
14WNK11.62301872
15RIPK41.55656591
16MKNK21.55274146
17ICK1.53921204
18BCR1.52686661
19MAP3K131.51631074
20FGFR41.48500103
21PDGFRB1.46356468
22TRPM71.42573212
23SGK31.41926602
24UHMK11.41171598
25MARK11.40806854
26NUAK11.38365189
27NLK1.37842249
28ALK1.36363355
29PDGFRA1.36127279
30SRPK11.34127588
31MELK1.33871710
32MAP3K41.32938325
33BTK1.27782309
34CAMK1D1.26537329
35CHEK11.26196213
36BLK1.25124811
37PIK3CG1.25050214
38MAP3K71.24584937
39MKNK11.23294690
40NEK91.20778837
41CSNK1A1L1.20398246
42MARK31.17913388
43EPHA41.15555468
44MAP3K141.15333579
45MET1.14663655
46JAK11.14414264
47PKN11.13337353
48CLK11.11764870
49ATM1.08405380
50TNIK1.06714461
51CSNK1D1.04755325
52TTK1.04338863
53FGR1.04181757
54STK31.04115837
55PAK61.03672837
56NTRK11.02852566
57KSR21.00486586
58PLK30.99050516
59MAP3K20.97880435
60SIK20.94494900
61NTRK20.94360524
62ATR0.92199813
63LATS10.91643772
64CDK10.91103947
65MAP4K10.90164176
66JAK30.89810440
67CHEK20.89763085
68RPS6KB20.89138820
69OXSR10.88099972
70PLK20.87977844
71CDK30.87884470
72PKN20.87608509
73CSNK1G20.86653202
74TEC0.85028668
75CDK20.84959232
76TYK20.83764192
77CDK40.83072032
78PASK0.82946869
79GSK3B0.81141723
80TAOK30.80669581
81CDK90.80632855
82MAPK100.80125500
83MAP3K60.79581527
84MAPK140.79050013
85CSK0.78505459
86TTN0.78148771
87CSNK1E0.77797126
88RPS6KB10.77726272
89SGK10.76537105
90CASK0.75974227
91FES0.74729142
92PRKDC0.74197310
93MAPK120.73777468
94YES10.73304803
95ZAP700.72920811
96PAK30.72295013
97CSNK1G10.72170434
98MAPK110.71194044
99MTOR0.70716275
100EPHB10.70184925
101NEK60.68755279
102CDC42BPA0.68438634
103CSNK1G30.68221465
104HCK0.67735590
105STK110.67499618
106STK40.66983172
107KSR10.66156592
108JAK20.64870274
109DYRK1A0.63558468
110HIPK20.63349121
111MAP2K30.63307719
112MAPK70.62520372
113MAPK130.62279961
114NEK20.61924761
115SYK0.61586617
116DMPK0.61405087
117RET0.61295741
118ITK0.60456428
119FGFR30.58111771
120PDK10.57793047
121PRKAA20.57747452
122CAMK40.57640184
123MAPK80.57633676
124MARK20.57526799
125SGK2230.57384249
126SGK4940.57384249
127ERBB30.56575924
128FRK0.55235221
129CDK50.55120330
130MAP2K70.54145363
131MAP3K10.53651050
132ROCK20.53439375
133PRPF4B0.52916540
134CDK60.52421389
135RPS6KA30.51126650
136PLK10.50741999
137AURKB0.49976540
138RAF10.49797578
139PRKAA10.49399558
140PRKCQ0.49185620
141SGK20.48686293
142TYRO30.48547322
143SCYL20.48089502
144INSR0.48022740
145ERBB20.47383612
146WNK40.47193400
147MAPK10.46726018
148PRKG10.46542548
149SMG10.45142393
150RPS6KA20.44127386
151CHUK0.43941770
152LCK0.43454266
153AKT10.41807117
154PDPK10.41318279
155CSF1R0.40568133
156IRAK10.39764336

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.04091735
2Acute myeloid leukemia_Homo sapiens_hsa052211.84630178
3Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.83158563
4Dorso-ventral axis formation_Homo sapiens_hsa043201.56535089
5Nicotine addiction_Homo sapiens_hsa050331.55113816
6Axon guidance_Homo sapiens_hsa043601.54446470
7Thyroid cancer_Homo sapiens_hsa052161.52140211
8Non-homologous end-joining_Homo sapiens_hsa034501.46615794
9Glutamatergic synapse_Homo sapiens_hsa047241.43427496
10Prolactin signaling pathway_Homo sapiens_hsa049171.42087763
11mRNA surveillance pathway_Homo sapiens_hsa030151.41580125
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.39918184
13MicroRNAs in cancer_Homo sapiens_hsa052061.35809076
14Long-term depression_Homo sapiens_hsa047301.34082016
15Long-term potentiation_Homo sapiens_hsa047201.31932849
16Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.28947538
17Phototransduction_Homo sapiens_hsa047441.28943453
18Type II diabetes mellitus_Homo sapiens_hsa049301.28786595
19VEGF signaling pathway_Homo sapiens_hsa043701.27414120
20Neurotrophin signaling pathway_Homo sapiens_hsa047221.24114854
21Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21656292
22Prostate cancer_Homo sapiens_hsa052151.21391835
23Hepatitis B_Homo sapiens_hsa051611.21011147
24Notch signaling pathway_Homo sapiens_hsa043301.20687402
25Fanconi anemia pathway_Homo sapiens_hsa034601.19963322
26Longevity regulating pathway - mammal_Homo sapiens_hsa042111.19448046
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.19132352
28Circadian entrainment_Homo sapiens_hsa047131.18941861
29Cell cycle_Homo sapiens_hsa041101.17818285
30Dopaminergic synapse_Homo sapiens_hsa047281.17772651
31Platelet activation_Homo sapiens_hsa046111.17339524
32Alcoholism_Homo sapiens_hsa050341.16546204
33Morphine addiction_Homo sapiens_hsa050321.16518558
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15978561
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15789579
36GABAergic synapse_Homo sapiens_hsa047271.13601501
37Glioma_Homo sapiens_hsa052141.12527885
38ErbB signaling pathway_Homo sapiens_hsa040121.12413532
39Amphetamine addiction_Homo sapiens_hsa050311.11245836
40Measles_Homo sapiens_hsa051621.11182883
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10132624
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09596605
43Cocaine addiction_Homo sapiens_hsa050301.08246754
44Renal cell carcinoma_Homo sapiens_hsa052111.07894474
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07544864
46Serotonergic synapse_Homo sapiens_hsa047261.07282429
47Insulin resistance_Homo sapiens_hsa049311.06211200
48Oocyte meiosis_Homo sapiens_hsa041141.04758686
49Wnt signaling pathway_Homo sapiens_hsa043101.04466478
50Lysine degradation_Homo sapiens_hsa003101.03934556
51Cholinergic synapse_Homo sapiens_hsa047251.02814580
52Phospholipase D signaling pathway_Homo sapiens_hsa040721.01253535
53Osteoclast differentiation_Homo sapiens_hsa043800.99622310
54Choline metabolism in cancer_Homo sapiens_hsa052310.99565837
55T cell receptor signaling pathway_Homo sapiens_hsa046600.99317970
56GnRH signaling pathway_Homo sapiens_hsa049120.96602380
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96497292
58Adherens junction_Homo sapiens_hsa045200.93001717
59Renin secretion_Homo sapiens_hsa049240.92935995
60Estrogen signaling pathway_Homo sapiens_hsa049150.92051028
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91933420
62Taste transduction_Homo sapiens_hsa047420.91822046
63Insulin signaling pathway_Homo sapiens_hsa049100.91704856
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91109437
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.91096282
66MAPK signaling pathway_Homo sapiens_hsa040100.90666576
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90429717
68Colorectal cancer_Homo sapiens_hsa052100.90097032
69HIF-1 signaling pathway_Homo sapiens_hsa040660.89730696
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89180069
71Insulin secretion_Homo sapiens_hsa049110.88520531
72Ether lipid metabolism_Homo sapiens_hsa005650.88217022
73Ras signaling pathway_Homo sapiens_hsa040140.88069037
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87551812
75Inositol phosphate metabolism_Homo sapiens_hsa005620.86851794
76Hepatitis C_Homo sapiens_hsa051600.86475146
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86331355
78Salivary secretion_Homo sapiens_hsa049700.86297897
79Circadian rhythm_Homo sapiens_hsa047100.85048229
80Chronic myeloid leukemia_Homo sapiens_hsa052200.84760983
81Melanogenesis_Homo sapiens_hsa049160.84630110
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84416439
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.83829168
84Homologous recombination_Homo sapiens_hsa034400.83334895
85Influenza A_Homo sapiens_hsa051640.82899156
86Autoimmune thyroid disease_Homo sapiens_hsa053200.82342390
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82229334
88Basal cell carcinoma_Homo sapiens_hsa052170.81853150
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81422045
90Endometrial cancer_Homo sapiens_hsa052130.81147191
91Hippo signaling pathway_Homo sapiens_hsa043900.81112488
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80975410
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79561997
94Systemic lupus erythematosus_Homo sapiens_hsa053220.78838673
95Oxytocin signaling pathway_Homo sapiens_hsa049210.78784465
96Non-small cell lung cancer_Homo sapiens_hsa052230.78423924
97AMPK signaling pathway_Homo sapiens_hsa041520.77866579
98Hedgehog signaling pathway_Homo sapiens_hsa043400.77384695
99Gap junction_Homo sapiens_hsa045400.77186298
100Viral carcinogenesis_Homo sapiens_hsa052030.76652504
101Apoptosis_Homo sapiens_hsa042100.76516325
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75049372
103Focal adhesion_Homo sapiens_hsa045100.75034819
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74900477
105Toxoplasmosis_Homo sapiens_hsa051450.74789818
106Tight junction_Homo sapiens_hsa045300.74542739
107Chemokine signaling pathway_Homo sapiens_hsa040620.74438133
108Ovarian steroidogenesis_Homo sapiens_hsa049130.73755762
109mTOR signaling pathway_Homo sapiens_hsa041500.73630688
110Pancreatic cancer_Homo sapiens_hsa052120.73523763
111cAMP signaling pathway_Homo sapiens_hsa040240.73389482
112Melanoma_Homo sapiens_hsa052180.73107811
113Gastric acid secretion_Homo sapiens_hsa049710.72326075
114TGF-beta signaling pathway_Homo sapiens_hsa043500.72288714
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.71616766
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.71330677
117Proteoglycans in cancer_Homo sapiens_hsa052050.71134684
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70854005
119Pathways in cancer_Homo sapiens_hsa052000.70381306
120RNA transport_Homo sapiens_hsa030130.70196235
121Leishmaniasis_Homo sapiens_hsa051400.69797887
122FoxO signaling pathway_Homo sapiens_hsa040680.69778680
123Rap1 signaling pathway_Homo sapiens_hsa040150.68961601
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68822833
125Thyroid hormone synthesis_Homo sapiens_hsa049180.68552434
126HTLV-I infection_Homo sapiens_hsa051660.67936872
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67334295
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.66635233
129TNF signaling pathway_Homo sapiens_hsa046680.66445602
130Herpes simplex infection_Homo sapiens_hsa051680.66289890
131ECM-receptor interaction_Homo sapiens_hsa045120.66286262
132Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65079247
133Mismatch repair_Homo sapiens_hsa034300.64400407
134Spliceosome_Homo sapiens_hsa030400.64310906
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64156853
136Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63913110
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63376716
138Small cell lung cancer_Homo sapiens_hsa052220.63194850
139Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61346945
140ABC transporters_Homo sapiens_hsa020100.59134043
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.57183768
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53661982
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50915142
144Tuberculosis_Homo sapiens_hsa051520.48234095
145Amoebiasis_Homo sapiens_hsa051460.47534244

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