TAC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1embryonic retina morphogenesis in camera-type eye (GO:0060059)7.33830470
2response to gravity (GO:0009629)6.96508819
3substrate-independent telencephalic tangential migration (GO:0021826)6.38699507
4substrate-independent telencephalic tangential interneuron migration (GO:0021843)6.38699507
5neurofilament cytoskeleton organization (GO:0060052)5.58622473
6establishment of mitochondrion localization, microtubule-mediated (GO:0034643)5.55507078
7mitochondrion transport along microtubule (GO:0047497)5.55507078
8regulation of bile acid biosynthetic process (GO:0070857)5.41090114
9establishment of mitochondrion localization (GO:0051654)5.35773141
10neuronal ion channel clustering (GO:0045161)5.35759785
11forebrain neuron differentiation (GO:0021879)5.29049138
12regulation of sarcomere organization (GO:0060297)5.13743376
13cerebellar granule cell differentiation (GO:0021707)5.11819712
14cellular response to vitamin D (GO:0071305)5.11276911
15locomotory exploration behavior (GO:0035641)4.87158979
16presynaptic membrane organization (GO:0097090)4.76653507
17regulation of cilium movement (GO:0003352)4.72737686
18positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.70680918
19positive regulation of growth hormone secretion (GO:0060124)4.64599895
20cerebellar Purkinje cell differentiation (GO:0021702)4.50862700
21head development (GO:0060322)4.44219173
22pyrimidine nucleobase catabolic process (GO:0006208)4.42612191
23response to phenylpropanoid (GO:0080184)4.41456200
24cell differentiation in hindbrain (GO:0021533)4.33912196
25uterus development (GO:0060065)4.26491253
26positive regulation of gastrulation (GO:2000543)4.25529806
27short-term memory (GO:0007614)4.17297309
28chemosensory behavior (GO:0007635)4.15037836
29positive regulation of cell cycle checkpoint (GO:1901978)4.14143800
30lymphangiogenesis (GO:0001946)3.99134071
31neuron recognition (GO:0008038)3.93553285
32central nervous system myelination (GO:0022010)3.93215524
33axon ensheathment in central nervous system (GO:0032291)3.93215524
34parturition (GO:0007567)3.92688697
35axonal fasciculation (GO:0007413)3.92384329
36regulation of microtubule-based movement (GO:0060632)3.91354642
37exploration behavior (GO:0035640)3.86154180
38venous blood vessel morphogenesis (GO:0048845)3.77689874
39synaptic transmission, dopaminergic (GO:0001963)3.77135891
40chaperone-mediated protein transport (GO:0072321)3.75662534
41behavioral response to nicotine (GO:0035095)3.73912103
42behavioral response to ethanol (GO:0048149)3.73738238
43regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71102747
44spinal cord association neuron differentiation (GO:0021527)3.67970493
45cellular response to vitamin (GO:0071295)3.63608057
46protein polyglutamylation (GO:0018095)3.61434934
47neuronal action potential propagation (GO:0019227)3.60258497
48urogenital system development (GO:0001655)3.49049045
49dentate gyrus development (GO:0021542)3.44425029
50ganglion development (GO:0061548)3.43847960
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.36872482
52nucleobase catabolic process (GO:0046113)3.36436999
53regulation of growth hormone secretion (GO:0060123)3.36053147
54regulation of telomerase activity (GO:0051972)3.33293792
55protein localization to synapse (GO:0035418)3.32145002
56protein neddylation (GO:0045116)3.30528530
57synapse assembly (GO:0007416)3.26081847
58ectodermal placode formation (GO:0060788)3.25392074
59glycerophospholipid catabolic process (GO:0046475)3.22909331
60behavioral response to cocaine (GO:0048148)3.22356788
61striatum development (GO:0021756)3.21718371
62negative regulation of response to food (GO:0032096)3.20862132
63negative regulation of appetite (GO:0032099)3.20862132
64response to histamine (GO:0034776)3.20128772
65negative regulation of transcription regulatory region DNA binding (GO:2000678)3.19873409
66regulation of synapse structural plasticity (GO:0051823)3.17324553
67regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.13344645
68regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.13344645
69body morphogenesis (GO:0010171)3.05039967
70mitochondrion localization (GO:0051646)3.04233899
71negative regulation of neurotransmitter secretion (GO:0046929)3.02913211
72neuronal stem cell maintenance (GO:0097150)3.02760803
73cartilage condensation (GO:0001502)3.01859991
74cell aggregation (GO:0098743)3.01859991
75nonmotile primary cilium assembly (GO:0035058)3.01808894
76cell migration in hindbrain (GO:0021535)3.01226933
77hepatocyte differentiation (GO:0070365)3.00458912
78transmission of nerve impulse (GO:0019226)2.99985488
79innervation (GO:0060384)2.99178821
80olfactory bulb development (GO:0021772)2.94423522
81adult walking behavior (GO:0007628)2.90923237
82positive regulation of neurotransmitter transport (GO:0051590)2.89472821
83microtubule bundle formation (GO:0001578)2.86980915
84mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.84827312
85pre-miRNA processing (GO:0031054)2.83004803
86axon extension (GO:0048675)2.82039490
87glutamate secretion (GO:0014047)2.81264270
88organelle transport along microtubule (GO:0072384)2.79253588
89axon cargo transport (GO:0008088)2.78704879
90embryonic body morphogenesis (GO:0010172)2.75235486
91negative regulation of heart rate (GO:0010459)2.75037084
92cytoskeleton-dependent intracellular transport (GO:0030705)2.73319621
93hypothalamus development (GO:0021854)2.70571608
94endoderm formation (GO:0001706)2.65052831
95regulation of voltage-gated calcium channel activity (GO:1901385)2.64009705
96microtubule-based transport (GO:0010970)2.62912753
97negative regulation of catecholamine secretion (GO:0033604)2.61915121
98icosanoid secretion (GO:0032309)2.61631660
99arachidonic acid secretion (GO:0050482)2.61631660
100positive regulation of organelle assembly (GO:1902117)2.60246880

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.81361689
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.98907087
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.16743066
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.08727174
5CBX2_27304074_Chip-Seq_ESCs_Mouse2.82654860
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.71406425
7REST_21632747_ChIP-Seq_MESCs_Mouse2.69922873
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.55917567
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47963979
10REST_18959480_ChIP-ChIP_MESCs_Mouse2.22327408
11SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11552228
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.10272772
13EZH2_27294783_Chip-Seq_ESCs_Mouse2.05904580
14IRF1_19129219_ChIP-ChIP_H3396_Human2.01822612
15ZNF274_21170338_ChIP-Seq_K562_Hela2.01203481
16RBPJ_22232070_ChIP-Seq_NCS_Mouse1.99472572
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.94171069
18RNF2_27304074_Chip-Seq_NSC_Mouse1.93898373
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93343123
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89588080
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89588080
22ERG_21242973_ChIP-ChIP_JURKAT_Human1.78743760
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.78060081
24RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.77861376
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.76823347
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70795911
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.67372519
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58051491
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55463247
30CTCF_27219007_Chip-Seq_Bcells_Human1.53561119
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.51499640
32RING1B_27294783_Chip-Seq_ESCs_Mouse1.51487408
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.51111037
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48804521
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46274538
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.45332919
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44172327
38GATA1_26923725_Chip-Seq_HPCs_Mouse1.44097110
39RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.43792108
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.41276465
41OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.39726791
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37864364
43SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37846959
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37615000
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25170009
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23440444
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22403919
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21777757
49SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21021995
50VDR_22108803_ChIP-Seq_LS180_Human1.20234059
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.16696075
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16377631
53SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13402491
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11171793
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.09047124
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08570252
57REST_19997604_ChIP-ChIP_NEURONS_Mouse1.06537755
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06103412
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06028145
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04823502
61RARB_27405468_Chip-Seq_BRAIN_Mouse1.02352187
62P300_19829295_ChIP-Seq_ESCs_Human1.02044846
63KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01008454
64NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.00595106
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00441004
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00441004
67TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99971352
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98447252
69CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98035568
70ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96871148
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96235497
72TP53_22573176_ChIP-Seq_HFKS_Human0.94456451
73NCOR_22424771_ChIP-Seq_293T_Human0.94287718
74ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93799328
75SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92948412
76STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90636137
77KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89510424
78AR_25329375_ChIP-Seq_VCAP_Human0.89467992
79JUN_21703547_ChIP-Seq_K562_Human0.88893483
80ETS1_20019798_ChIP-Seq_JURKAT_Human0.87479941
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.85989606
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85730683
83YY1_21170310_ChIP-Seq_MESCs_Mouse0.84899624
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84538296
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83647053
86TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.83122194
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81507690
88JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.80811842
89GATA3_21878914_ChIP-Seq_MCF-7_Human0.80449892
90FUS_26573619_Chip-Seq_HEK293_Human0.80314606
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79149424
92SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.78015292
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.76657798
94CREB1_15753290_ChIP-ChIP_HEK293T_Human0.75930376
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.75366793
96SMAD3_21741376_ChIP-Seq_ESCs_Human0.75071070
97TBX3_20139965_ChIP-Seq_ESCs_Mouse0.73407151
98TBX3_20139965_ChIP-Seq_MESCs_Mouse0.73043977
99EWS_26573619_Chip-Seq_HEK293_Human0.72500404
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.70838478

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting5.93463013
2MP0003123_paternal_imprinting4.26695679
3MP0003880_abnormal_central_pattern3.96968746
4MP0005423_abnormal_somatic_nervous3.95263618
5MP0006276_abnormal_autonomic_nervous3.30008515
6MP0001542_abnormal_bone_strength2.84117016
7MP0002163_abnormal_gland_morphology2.82052081
8MP0003890_abnormal_embryonic-extraembry2.81725139
9MP0010368_abnormal_lymphatic_system2.56459135
10MP0001188_hyperpigmentation2.55311970
11MP0003121_genomic_imprinting2.53155170
12MP0000778_abnormal_nervous_system2.35505611
13MP0002822_catalepsy2.34360647
14MP0008789_abnormal_olfactory_epithelium2.16520353
15MP0002184_abnormal_innervation2.15253542
16MP0002653_abnormal_ependyma_morphology2.13756625
17MP0004185_abnormal_adipocyte_glucose2.12422696
18MP0004859_abnormal_synaptic_plasticity2.08574742
19MP0000955_abnormal_spinal_cord2.07844779
20MP0004145_abnormal_muscle_electrophysio2.07409933
21MP0005394_taste/olfaction_phenotype1.99240264
22MP0005499_abnormal_olfactory_system1.99240264
23MP0005379_endocrine/exocrine_gland_phen1.91891235
24MP0002272_abnormal_nervous_system1.87518508
25MP0008877_abnormal_DNA_methylation1.86888030
26MP0005645_abnormal_hypothalamus_physiol1.81772555
27MP0003011_delayed_dark_adaptation1.72721630
28MP0003122_maternal_imprinting1.62737300
29MP0009046_muscle_twitch1.58408440
30MP0006292_abnormal_olfactory_placode1.50234920
31MP0002752_abnormal_somatic_nervous1.49280621
32MP0004134_abnormal_chest_morphology1.49049110
33MP0009379_abnormal_foot_pigmentation1.46179548
34MP0002882_abnormal_neuron_morphology1.43842787
35MP0002160_abnormal_reproductive_system1.42615993
36MP0001529_abnormal_vocalization1.40866749
37MP0003635_abnormal_synaptic_transmissio1.39536748
38MP0002063_abnormal_learning/memory/cond1.38490592
39MP0004742_abnormal_vestibular_system1.38137355
40MP0005083_abnormal_biliary_tract1.35746708
41MP0001986_abnormal_taste_sensitivity1.33687371
42MP0009745_abnormal_behavioral_response1.33505089
43MP0001485_abnormal_pinna_reflex1.33199266
44MP0002557_abnormal_social/conspecific_i1.31969755
45MP0005551_abnormal_eye_electrophysiolog1.31684031
46MP0003119_abnormal_digestive_system1.28579884
47MP0002572_abnormal_emotion/affect_behav1.26895178
48MP0001905_abnormal_dopamine_level1.26681423
49MP0004811_abnormal_neuron_physiology1.25983219
50MP0002734_abnormal_mechanical_nocicepti1.22851434
51MP0001486_abnormal_startle_reflex1.21076984
52MP0001984_abnormal_olfaction1.18246451
53MP0006072_abnormal_retinal_apoptosis1.15056079
54MP0003861_abnormal_nervous_system1.06320351
55MP0001970_abnormal_pain_threshold1.06028159
56MP0002909_abnormal_adrenal_gland1.04837311
57MP0004133_heterotaxia1.03424048
58MP0002152_abnormal_brain_morphology1.03013652
59MP0004142_abnormal_muscle_tone1.02474605
60MP0001286_abnormal_eye_development1.01338180
61MP0004270_analgesia1.00885390
62MP0002928_abnormal_bile_duct1.00375463
63MP0003942_abnormal_urinary_system1.00162245
64MP0001440_abnormal_grooming_behavior0.97783406
65MP0005220_abnormal_exocrine_pancreas0.96497207
66MP0002067_abnormal_sensory_capabilities0.94587075
67MP0005195_abnormal_posterior_eye0.93094042
68MP0003941_abnormal_skin_development0.92875825
69MP0003646_muscle_fatigue0.92197508
70MP0002064_seizures0.90910794
71MP0002735_abnormal_chemical_nociception0.90799095
72MP0000631_abnormal_neuroendocrine_gland0.90154916
73MP0001968_abnormal_touch/_nociception0.88545603
74MP0005389_reproductive_system_phenotype0.87442350
75MP0004885_abnormal_endolymph0.86433492
76MP0001879_abnormal_lymphatic_vessel0.85221128
77MP0003315_abnormal_perineum_morphology0.84623482
78MP0001293_anophthalmia0.82214681
79MP0002733_abnormal_thermal_nociception0.82008073
80MP0003879_abnormal_hair_cell0.81794625
81MP0005084_abnormal_gallbladder_morpholo0.80466692
82MP0005448_abnormal_energy_balance0.79279679
83MP0005646_abnormal_pituitary_gland0.76666544
84MP0002102_abnormal_ear_morphology0.75380353
85MP0002233_abnormal_nose_morphology0.74997631
86MP0002066_abnormal_motor_capabilities/c0.74336618
87MP0009115_abnormal_fat_cell0.72882293
88MP0002229_neurodegeneration0.72259968
89MP0001502_abnormal_circadian_rhythm0.71313001
90MP0002069_abnormal_eating/drinking_beha0.70102610
91MP0005377_hearing/vestibular/ear_phenot0.70065667
92MP0003878_abnormal_ear_physiology0.70065667
93MP0002638_abnormal_pupillary_reflex0.68673281
94MP0005253_abnormal_eye_physiology0.68469210
95MP0003943_abnormal_hepatobiliary_system0.68303255
96MP0000639_abnormal_adrenal_gland0.68280178
97MP0000026_abnormal_inner_ear0.66684728
98MP0001919_abnormal_reproductive_system0.64331986
99MP0002210_abnormal_sex_determination0.63851878
100MP0002751_abnormal_autonomic_nervous0.63025934

Predicted human phenotypes

RankGene SetZ-score
1Abnormal pancreas size (HP:0012094)6.95793474
2Myokymia (HP:0002411)6.53410708
3Hepatoblastoma (HP:0002884)5.22888006
4Diastasis recti (HP:0001540)5.09828735
5Neoplasm of the adrenal cortex (HP:0100641)4.97686856
6Neonatal hypoglycemia (HP:0001998)4.28824580
7Metaphyseal dysplasia (HP:0100255)4.07240337
8Progressive cerebellar ataxia (HP:0002073)4.02966947
9Impaired vibration sensation in the lower limbs (HP:0002166)3.82835303
10Abnormal hair whorl (HP:0010721)3.79280187
11Adrenal hypoplasia (HP:0000835)3.69779695
12Medial flaring of the eyebrow (HP:0010747)3.38884818
13Limb dystonia (HP:0002451)3.28961457
14Anomalous pulmonary venous return (HP:0010772)3.19494018
15Gait imbalance (HP:0002141)3.19468157
16Abnormality of midbrain morphology (HP:0002418)3.08556686
17Molar tooth sign on MRI (HP:0002419)3.08556686
18Rib fusion (HP:0000902)3.01984207
19Congenital primary aphakia (HP:0007707)2.96143837
20Growth hormone deficiency (HP:0000824)2.94832328
21Increased hepatocellular lipid droplets (HP:0006565)2.82993027
22Nephrogenic diabetes insipidus (HP:0009806)2.82649908
23Vaginal atresia (HP:0000148)2.79848092
24Abnormality of the pulmonary veins (HP:0011718)2.76352556
25Nephronophthisis (HP:0000090)2.74659366
26Genital tract atresia (HP:0001827)2.68737679
27Abnormality of the labia minora (HP:0012880)2.68231935
28Chronic hepatic failure (HP:0100626)2.61379494
29Abnormality of the corticospinal tract (HP:0002492)2.61040153
30Focal dystonia (HP:0004373)2.60689233
31Pendular nystagmus (HP:0012043)2.60625153
32Pancreatic fibrosis (HP:0100732)2.54548532
33Renal Fanconi syndrome (HP:0001994)2.49018998
34Neoplasm of the adrenal gland (HP:0100631)2.41999893
35Enlarged kidneys (HP:0000105)2.38940679
36Labial hypoplasia (HP:0000066)2.36439329
37Osteomalacia (HP:0002749)2.34644236
38Lipid accumulation in hepatocytes (HP:0006561)2.33020609
39Poor coordination (HP:0002370)2.32438171
40Abnormality of the renal medulla (HP:0100957)2.30514066
41Polyphagia (HP:0002591)2.29598382
42Stenosis of the external auditory canal (HP:0000402)2.24173057
43Tubulointerstitial nephritis (HP:0001970)2.22790207
44Supranuclear gaze palsy (HP:0000605)2.19787776
45Overgrowth (HP:0001548)2.19411099
46Acute necrotizing encephalopathy (HP:0006965)2.18016735
47Specific learning disability (HP:0001328)2.16971129
48True hermaphroditism (HP:0010459)2.15296310
49Methylmalonic acidemia (HP:0002912)2.15187686
50Chorioretinal atrophy (HP:0000533)2.15117716
51Poor suck (HP:0002033)2.14848385
52Hypoplastic female external genitalia (HP:0012815)2.14306917
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12566452
54Broad-based gait (HP:0002136)2.11849496
55Fetal akinesia sequence (HP:0001989)2.11007840
56Bony spicule pigmentary retinopathy (HP:0007737)2.09098669
57Potter facies (HP:0002009)2.08922332
58Facial shape deformation (HP:0011334)2.08922332
59Abnormality of renal resorption (HP:0011038)2.07935875
60Shawl scrotum (HP:0000049)2.04802329
61Anencephaly (HP:0002323)2.00883326
62Increased intramyocellular lipid droplets (HP:0012240)2.00459313
63Abnormal mitochondria in muscle tissue (HP:0008316)1.99963025
64Spastic tetraplegia (HP:0002510)1.99389561
65Pancreatic cysts (HP:0001737)1.99024633
66Abnormality of cells of the erythroid lineage (HP:0012130)1.98818239
67Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98426552
68Degeneration of the lateral corticospinal tracts (HP:0002314)1.98426552
69Drooling (HP:0002307)1.96716713
70Tubular atrophy (HP:0000092)1.96711584
71Urinary bladder sphincter dysfunction (HP:0002839)1.95132428
72Retinitis pigmentosa (HP:0000510)1.94185955
73Germ cell neoplasia (HP:0100728)1.91883796
74Abolished electroretinogram (ERG) (HP:0000550)1.89901327
75Impaired vibratory sensation (HP:0002495)1.89446473
76Mitochondrial inheritance (HP:0001427)1.88036179
77Cortical dysplasia (HP:0002539)1.87610903
78Optic nerve coloboma (HP:0000588)1.87477789
79Double outlet right ventricle (HP:0001719)1.87217941
80Congenital malformation of the right heart (HP:0011723)1.87217941
81Failure to thrive in infancy (HP:0001531)1.87114610
82Respiratory difficulties (HP:0002880)1.86445306
83Thoracolumbar scoliosis (HP:0002944)1.83888801
84Torticollis (HP:0000473)1.83525133
85Narrow forehead (HP:0000341)1.83455689
86Agitation (HP:0000713)1.79470849
87Epiphyseal dysplasia (HP:0002656)1.78934725
88Increased CSF lactate (HP:0002490)1.77840691
89Partial duplication of thumb phalanx (HP:0009944)1.77074376
90Absent eyebrow (HP:0002223)1.76895273
91Excessive salivation (HP:0003781)1.76088558
92Hyperphosphaturia (HP:0003109)1.75974382
93Micropenis (HP:0000054)1.73374255
94Prominent occiput (HP:0000269)1.73311079
95Long foot (HP:0001833)1.72417001
96Incomplete penetrance (HP:0003829)1.72008122
97Occipital encephalocele (HP:0002085)1.70745473
98Multicystic kidney dysplasia (HP:0000003)1.70185252
99Chorioretinal coloboma (HP:0000567)1.69539834
100Postaxial hand polydactyly (HP:0001162)1.67585302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MINK13.70667782
2NTRK33.57382976
3BMPR1B2.92971145
4MARK12.78931042
5DYRK22.70864219
6DYRK32.51865808
7WNK42.49375809
8PIM22.30742945
9MAP3K42.30368494
10PAK32.25478622
11BCR2.24378309
12ZAK2.19810480
13MAP2K72.16731445
14CASK2.01964608
15ARAF1.94063756
16WNK31.86223804
17STK161.85203110
18MARK21.84806278
19SIK21.83546602
20DYRK1B1.77839259
21PRKCG1.73987587
22ICK1.66933653
23BRAF1.65464790
24CSNK1G21.62326007
25PDK21.60007679
26TAF11.52844210
27NTRK21.34510171
28SGK4941.33513832
29SGK2231.33513832
30PINK11.28986828
31LIMK11.28472914
32STK241.24953640
33CAMKK11.24040857
34CDK51.15565868
35CAMK1D1.15233581
36GRK11.15174254
37MUSK1.14492113
38CSNK1G31.14097988
39ADRBK21.12139751
40EPHA41.11981609
41CAMK1G1.08165166
42CSNK1A1L1.06789558
43MAP2K41.04348591
44TYRO31.03272245
45NUAK11.01038117
46MAP3K91.00455430
47MKNK20.99821614
48SGK20.92671817
49RPS6KA20.88763367
50CDK190.87817054
51MAPK130.87415642
52CSNK1G10.86158359
53STK110.85346987
54CAMKK20.84500892
55SIK30.83324071
56DYRK1A0.81149748
57BRSK10.77006786
58CSNK1E0.76748915
59PRKCI0.74078812
60STK390.72994361
61PRKCH0.70515746
62STK30.70271073
63PNCK0.66174176
64CAMK10.64123788
65DAPK20.62903720
66DAPK30.62769893
67TNIK0.62002254
68MAP3K110.61853508
69TIE10.61831189
70CSNK1A10.60495780
71DMPK0.59699515
72AKT30.57950277
73EPHB20.57541121
74RPS6KA60.57254701
75PRKACA0.53983605
76RPS6KC10.53878140
77RPS6KL10.53878140
78OXSR10.53122143
79BCKDK0.50603534
80MAPK80.48809979
81CDK140.48740485
82PRKCZ0.47829948
83MAPK150.46907118
84PRKCE0.45538210
85PRKCD0.45185127
86PRKCQ0.44821737
87MAP3K60.44606172
88MAP4K20.44455192
89PDK10.43164025
90ERBB20.40496691
91AKT10.40437132
92STK38L0.36737513
93GRK50.36554569
94PAK10.36496884
95STK380.36364995
96VRK10.35634961
97LATS20.34984362
98PRKG10.34733203
99SGK30.33859557
100RAF10.33855734

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.20487932
2Parkinsons disease_Homo sapiens_hsa050123.41263223
3Steroid biosynthesis_Homo sapiens_hsa001002.86898531
4Synaptic vesicle cycle_Homo sapiens_hsa047212.85604358
5Cardiac muscle contraction_Homo sapiens_hsa042602.79168728
6Collecting duct acid secretion_Homo sapiens_hsa049662.59630862
7Phototransduction_Homo sapiens_hsa047442.52844988
8Nicotine addiction_Homo sapiens_hsa050332.24923003
9Huntingtons disease_Homo sapiens_hsa050162.24222055
10Alzheimers disease_Homo sapiens_hsa050102.20623496
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.14381523
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.11782013
13Ribosome_Homo sapiens_hsa030102.10511699
14Morphine addiction_Homo sapiens_hsa050322.03214673
15Dopaminergic synapse_Homo sapiens_hsa047282.01100359
16GABAergic synapse_Homo sapiens_hsa047271.93765993
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.88275335
18Protein export_Homo sapiens_hsa030601.87891654
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82721250
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.81964254
21Long-term depression_Homo sapiens_hsa047301.79980715
22Insulin secretion_Homo sapiens_hsa049111.71042558
23Glutamatergic synapse_Homo sapiens_hsa047241.65115382
24Axon guidance_Homo sapiens_hsa043601.60332835
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52034874
26Circadian entrainment_Homo sapiens_hsa047131.38453949
27Serotonergic synapse_Homo sapiens_hsa047261.35038454
28RNA polymerase_Homo sapiens_hsa030201.30547512
29Sulfur relay system_Homo sapiens_hsa041221.29089280
30Vibrio cholerae infection_Homo sapiens_hsa051101.21151261
31Amphetamine addiction_Homo sapiens_hsa050311.20291496
32Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.19054833
33Cholinergic synapse_Homo sapiens_hsa047251.15885194
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10395886
35Cocaine addiction_Homo sapiens_hsa050301.02559235
36RNA degradation_Homo sapiens_hsa030181.01523248
37Gap junction_Homo sapiens_hsa045400.98056649
38Homologous recombination_Homo sapiens_hsa034400.91851573
39Fanconi anemia pathway_Homo sapiens_hsa034600.88698032
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87240193
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86633578
42Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86507531
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85326062
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84901323
45Oxytocin signaling pathway_Homo sapiens_hsa049210.83299296
46Linoleic acid metabolism_Homo sapiens_hsa005910.83109363
47Notch signaling pathway_Homo sapiens_hsa043300.82165561
48Olfactory transduction_Homo sapiens_hsa047400.81850913
49Gastric acid secretion_Homo sapiens_hsa049710.80900676
50Basal cell carcinoma_Homo sapiens_hsa052170.80699991
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79936536
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79816294
53Basal transcription factors_Homo sapiens_hsa030220.79434965
54Pyruvate metabolism_Homo sapiens_hsa006200.77787665
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75123922
56Alcoholism_Homo sapiens_hsa050340.73856078
57Long-term potentiation_Homo sapiens_hsa047200.71208622
58Wnt signaling pathway_Homo sapiens_hsa043100.69370596
59Hedgehog signaling pathway_Homo sapiens_hsa043400.68571439
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68562010
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67555024
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.66643991
63Thyroid hormone synthesis_Homo sapiens_hsa049180.62942507
64Taste transduction_Homo sapiens_hsa047420.62275709
65Melanogenesis_Homo sapiens_hsa049160.62129355
66Regulation of autophagy_Homo sapiens_hsa041400.60327345
67Peroxisome_Homo sapiens_hsa041460.59817701
68Ether lipid metabolism_Homo sapiens_hsa005650.57117206
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.56720459
70Retinol metabolism_Homo sapiens_hsa008300.56139140
71MAPK signaling pathway_Homo sapiens_hsa040100.53875858
72Dilated cardiomyopathy_Homo sapiens_hsa054140.52899459
73VEGF signaling pathway_Homo sapiens_hsa043700.52512509
74Hippo signaling pathway_Homo sapiens_hsa043900.52379572
75Dorso-ventral axis formation_Homo sapiens_hsa043200.52169730
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50945655
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49877060
78Ovarian steroidogenesis_Homo sapiens_hsa049130.45415055
79Metabolic pathways_Homo sapiens_hsa011000.45093408
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44139192
81Selenocompound metabolism_Homo sapiens_hsa004500.43142212
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.41576513
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41298104
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41095874
85Calcium signaling pathway_Homo sapiens_hsa040200.41070503
86Oocyte meiosis_Homo sapiens_hsa041140.38730901
87ErbB signaling pathway_Homo sapiens_hsa040120.37487406
88cAMP signaling pathway_Homo sapiens_hsa040240.36695575
89mRNA surveillance pathway_Homo sapiens_hsa030150.36270260
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.35665461
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34969533
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34714146
93Ras signaling pathway_Homo sapiens_hsa040140.32969756
94Salivary secretion_Homo sapiens_hsa049700.32722450
95Tight junction_Homo sapiens_hsa045300.32128014
96Rap1 signaling pathway_Homo sapiens_hsa040150.29990216
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28754166
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27110792
99Renin secretion_Homo sapiens_hsa049240.26976105
100Choline metabolism in cancer_Homo sapiens_hsa052310.26951605

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