SYVN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.22102284
2L-phenylalanine catabolic process (GO:0006559)5.22102284
3L-phenylalanine metabolic process (GO:0006558)4.95408076
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.95408076
5Golgi transport vesicle coating (GO:0048200)4.58080528
6COPI coating of Golgi vesicle (GO:0048205)4.58080528
7alpha-linolenic acid metabolic process (GO:0036109)4.55633354
8aromatic amino acid family catabolic process (GO:0009074)4.55159976
9regulation of cholesterol homeostasis (GO:2000188)4.40932044
10kynurenine metabolic process (GO:0070189)4.33917485
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.29890353
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.29446642
13complement activation, classical pathway (GO:0006958)4.27820135
14negative regulation of fibrinolysis (GO:0051918)4.26272862
15complement activation, alternative pathway (GO:0006957)4.17522424
16regulation of protein activation cascade (GO:2000257)4.09612231
17tryptophan catabolic process (GO:0006569)4.07689544
18indole-containing compound catabolic process (GO:0042436)4.07689544
19indolalkylamine catabolic process (GO:0046218)4.07689544
20sulfur amino acid catabolic process (GO:0000098)4.04684890
21* activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.02675101
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.98953581
23urea cycle (GO:0000050)3.97276107
24urea metabolic process (GO:0019627)3.97276107
25protein carboxylation (GO:0018214)3.95573040
26peptidyl-glutamic acid carboxylation (GO:0017187)3.95573040
27cysteine metabolic process (GO:0006534)3.95498606
28COPII vesicle coating (GO:0048208)3.95335555
29negative regulation of erythrocyte differentiation (GO:0045647)3.90124119
30regulation of complement activation (GO:0030449)3.86924924
31* positive regulation of nuclease activity (GO:0032075)3.85781089
32bile acid biosynthetic process (GO:0006699)3.83948660
33tryptophan metabolic process (GO:0006568)3.83854521
34complement activation (GO:0006956)3.83534072
35B cell receptor signaling pathway (GO:0050853)3.82931780
36negative regulation of cholesterol transport (GO:0032375)3.80758782
37negative regulation of sterol transport (GO:0032372)3.80758782
38regulation of fibrinolysis (GO:0051917)3.74632836
39germinal center formation (GO:0002467)3.73177089
40mannose metabolic process (GO:0006013)3.72649219
41high-density lipoprotein particle remodeling (GO:0034375)3.72519372
42glyoxylate metabolic process (GO:0046487)3.72240128
43intestinal cholesterol absorption (GO:0030299)3.71223845
44protein retention in ER lumen (GO:0006621)3.67520797
45antigen processing and presentation of endogenous antigen (GO:0019883)3.61970911
46lysine metabolic process (GO:0006553)3.61935278
47lysine catabolic process (GO:0006554)3.61935278
48valine metabolic process (GO:0006573)3.60818104
49nitrogen cycle metabolic process (GO:0071941)3.58862292
50cellular modified amino acid catabolic process (GO:0042219)3.55439518
51* regulation of nuclease activity (GO:0032069)3.51218169
52* endoplasmic reticulum unfolded protein response (GO:0030968)3.49098888
53regulation of triglyceride catabolic process (GO:0010896)3.47246570
54positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.46726312
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.45844194
56antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.45844194
57regulation of fatty acid beta-oxidation (GO:0031998)3.44802600
58homocysteine metabolic process (GO:0050667)3.41402568
59reverse cholesterol transport (GO:0043691)3.40273655
60* cellular response to unfolded protein (GO:0034620)3.33564217
61bile acid metabolic process (GO:0008206)3.28772055
62* ER-nucleus signaling pathway (GO:0006984)3.25991821
63positive regulation of histone deacetylation (GO:0031065)3.25227991
64triglyceride homeostasis (GO:0070328)3.24876464
65acylglycerol homeostasis (GO:0055090)3.24876464
66NIK/NF-kappaB signaling (GO:0038061)3.22348812
67plasma lipoprotein particle clearance (GO:0034381)3.21892614
684-hydroxyproline metabolic process (GO:0019471)3.21213908
69protein activation cascade (GO:0072376)3.20075889
70positive thymic T cell selection (GO:0045059)3.19695389
71L-alpha-amino acid transmembrane transport (GO:1902475)3.18442905
72dicarboxylic acid biosynthetic process (GO:0043650)3.15737780
73positive regulation of fatty acid beta-oxidation (GO:0032000)3.14222658
74phospholipid efflux (GO:0033700)3.14118046
75detection of bacterium (GO:0016045)3.13335313
76immunoglobulin mediated immune response (GO:0016064)3.11276290
77exocrine pancreas development (GO:0031017)3.10451172
782-oxoglutarate metabolic process (GO:0006103)3.10397773
79* cellular response to topologically incorrect protein (GO:0035967)3.10335762
80negative regulation of cell killing (GO:0031342)3.10148296
81negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.10148296
82aromatic amino acid family metabolic process (GO:0009072)3.08462315
83thymic T cell selection (GO:0045061)3.06151781
84positive regulation of fatty acid biosynthetic process (GO:0045723)3.06129277
85serine family amino acid catabolic process (GO:0009071)3.05169520
86coenzyme catabolic process (GO:0009109)3.04296214
87plasma lipoprotein particle remodeling (GO:0034369)3.02212271
88protein-lipid complex remodeling (GO:0034368)3.02212271
89macromolecular complex remodeling (GO:0034367)3.02212271
90positive regulation of triglyceride metabolic process (GO:0090208)3.00705235
91regulation of gamma-delta T cell activation (GO:0046643)3.00237406
92positive regulation of triglyceride biosynthetic process (GO:0010867)2.99063702
93alpha-amino acid catabolic process (GO:1901606)2.96538475
94ethanol oxidation (GO:0006069)2.94491495
95positive regulation of lipid catabolic process (GO:0050996)2.92841122
96glutamate metabolic process (GO:0006536)2.90011972
97CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.90002535
98protein-lipid complex assembly (GO:0065005)2.89894417
99detection of other organism (GO:0098543)2.89442450
100glycine metabolic process (GO:0006544)2.89333445
101regulation of interferon-beta biosynthetic process (GO:0045357)2.88232328
102* ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.88045563
103positive regulation of lipoprotein lipase activity (GO:0051006)2.87925117
104positive regulation of triglyceride lipase activity (GO:0061365)2.87925117
105* response to endoplasmic reticulum stress (GO:0034976)2.87627958
106plasma lipoprotein particle assembly (GO:0034377)2.86949258
107cellular response to virus (GO:0098586)2.86491546
108regulation of gamma-delta T cell differentiation (GO:0045586)2.86385044
109positive regulation of gamma-delta T cell activation (GO:0046645)2.86178212
110acute-phase response (GO:0006953)2.85636332
111tyrosine metabolic process (GO:0006570)2.83963577
112negative regulation of protein activation cascade (GO:2000258)2.83083422
113regulation of glucose import in response to insulin stimulus (GO:2001273)2.82816471
114cytolysis (GO:0019835)2.82106029
115cellular amino acid catabolic process (GO:0009063)2.81494416
116bile acid and bile salt transport (GO:0015721)2.80543054
117negative regulation of lipid transport (GO:0032369)2.80463722
118benzene-containing compound metabolic process (GO:0042537)2.79453205
119regulation of type I interferon-mediated signaling pathway (GO:0060338)2.72779437
120macrophage activation involved in immune response (GO:0002281)2.71306195
121antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.70306610
122regulation of histone H3-K27 methylation (GO:0061085)2.68614489
123positive regulation by symbiont of host defense response (GO:0052509)2.67824237
124modulation by symbiont of host defense response (GO:0052031)2.67824237
125modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.67824237
126modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.67824237
127positive regulation by organism of defense response of other organism involved in symbiotic interact2.67824237
128modulation by symbiont of host immune response (GO:0052553)2.67824237
129response to muramyl dipeptide (GO:0032495)2.66386292
130positive regulation of Cdc42 GTPase activity (GO:0043089)2.63449790
131response to type I interferon (GO:0034340)2.62682300
132type I interferon signaling pathway (GO:0060337)2.59320389
133cellular response to type I interferon (GO:0071357)2.59320389
134modulation by symbiont of host cellular process (GO:0044068)2.59289616
135negative regulation of viral release from host cell (GO:1902187)2.56545449
136activation of Rac GTPase activity (GO:0032863)2.56256660
137histone H3-K36 demethylation (GO:0070544)2.55860836
138regulation of superoxide anion generation (GO:0032928)2.53618792
139T cell selection (GO:0045058)2.51806978
140regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.51634437
141regulation of dendritic cell antigen processing and presentation (GO:0002604)2.49881677
142positive regulation of B cell differentiation (GO:0045579)2.49583807
143positive regulation of Rap GTPase activity (GO:0032854)2.49104456
144positive regulation of extracellular matrix organization (GO:1903055)2.47683450
145regulation of T-helper 2 cell differentiation (GO:0045628)2.47397700
146modulation by virus of host process (GO:0019054)2.47376930
147activation of MAPKKK activity (GO:0000185)2.47332326
148N-acetylneuraminate metabolic process (GO:0006054)2.46234413
149detection of external biotic stimulus (GO:0098581)2.45002368
150retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.44203495
151protein localization to endosome (GO:0036010)2.43509257
152defense response to protozoan (GO:0042832)2.42708693
153negative thymic T cell selection (GO:0045060)2.40875035
154response to laminar fluid shear stress (GO:0034616)2.40170662
155B cell homeostasis (GO:0001782)2.39860413
156proline biosynthetic process (GO:0006561)2.38101818
1573-UTR-mediated mRNA stabilization (GO:0070935)2.37793216
158regulation of B cell receptor signaling pathway (GO:0050855)2.36348754
159response to peptidoglycan (GO:0032494)2.36055868
160negative regulation of cell size (GO:0045792)2.35106298
161regulation of extracellular matrix disassembly (GO:0010715)2.31187359
162myeloid dendritic cell differentiation (GO:0043011)2.30600946
163focal adhesion assembly (GO:0048041)2.30485547
164cell-substrate adherens junction assembly (GO:0007045)2.30485547
165response to protozoan (GO:0001562)2.29715426
166apoptotic process involved in morphogenesis (GO:0060561)2.29444127
167cellular extravasation (GO:0045123)2.28703455
168positive regulation of protein deacetylation (GO:0090312)2.28535116
169regulation of monocyte differentiation (GO:0045655)2.28233915
170regulation of early endosome to late endosome transport (GO:2000641)2.28034348
171negative regulation of toll-like receptor signaling pathway (GO:0034122)2.26821878
172regulation of leukocyte degranulation (GO:0043300)2.25522767
173embryonic process involved in female pregnancy (GO:0060136)2.24682798
174negative regulation of fatty acid biosynthetic process (GO:0045717)2.24054726
175mucosal-associated lymphoid tissue development (GO:0048537)2.22351442
176Peyers patch development (GO:0048541)2.22351442

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.94124235
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.98666623
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.70303744
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.86566248
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.20071428
6* MYC_22102868_ChIP-Seq_BL_Human3.13060503
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.05175005
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.99695159
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.83540868
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.60869119
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.58321636
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.52442117
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.51892885
14VDR_21846776_ChIP-Seq_THP-1_Human2.23917331
15E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.10790386
16LXR_22292898_ChIP-Seq_THP-1_Human2.08197457
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.05455718
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.04946199
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.99306387
20CLOCK_20551151_ChIP-Seq_293T_Human1.97018599
21* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86651248
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.83236890
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.81551101
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80102632
25TCF7_22412390_ChIP-Seq_EML_Mouse1.79156447
26GATA1_22025678_ChIP-Seq_K562_Human1.78086825
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74093636
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71603671
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67753247
30KDM2B_26808549_Chip-Seq_DND41_Human1.67399785
31* ELK3_25401928_ChIP-Seq_HUVEC_Human1.67100239
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60675867
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59506773
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50612372
35MAF_26560356_Chip-Seq_TH1_Human1.50289411
36* UTX_26944678_Chip-Seq_JUKART_Human1.47403489
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46324787
38VDR_24763502_ChIP-Seq_THP-1_Human1.42655816
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41631784
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.39454269
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39409158
42* SMC4_20622854_ChIP-Seq_HELA_Human1.38674762
43* SA1_27219007_Chip-Seq_ERYTHROID_Human1.36460252
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35399122
45FOXA2_19822575_ChIP-Seq_HepG2_Human1.35013905
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34801815
47* RACK7_27058665_Chip-Seq_MCF-7_Human1.34724670
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34134877
49ZNF263_19887448_ChIP-Seq_K562_Human1.28790278
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28444898
51TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.28263227
52* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26419606
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25159262
54BCL6_27268052_Chip-Seq_Bcells_Human1.23609931
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22982228
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22901493
57PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22527755
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21850719
59IRF8_27001747_Chip-Seq_BMDM_Mouse1.21820011
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21029221
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20934861
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18735056
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.18283956
64MYB_26560356_Chip-Seq_TH1_Human1.16590355
65* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16253476
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16182584
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16179845
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16122307
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15756394
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15066941
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14337315
72CIITA_25753668_ChIP-Seq_RAJI_Human1.13020787
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12668529
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12155209
75RUNX1_27514584_Chip-Seq_MCF-7_Human1.12013125
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11959800
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10059065
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07923055
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07903349
80* GATA6_25053715_ChIP-Seq_YYC3_Human1.07146740
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.06196193
82ATF3_27146783_Chip-Seq_COLON_Human1.06181492
83GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06022239
84RUNX_20019798_ChIP-Seq_JUKART_Human1.05769179
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05276207
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.04490068
87* CREB1_26743006_Chip-Seq_LNCaP_Human1.03658514
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03437182
89GATA1_19941827_ChIP-Seq_MEL_Mouse1.03352463
90* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03170480
91FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03052961
92* MAF_26560356_Chip-Seq_TH2_Human1.02533165
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02222084
94MYB_26560356_Chip-Seq_TH2_Human1.02075399
95GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01860263
96* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01528181
97IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01305630
98SPI1_23127762_ChIP-Seq_K562_Human1.01060088
99* NCOR1_26117541_ChIP-Seq_K562_Human1.00905362
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99879505
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99573457
102SCL_19346495_ChIP-Seq_HPC-7_Human0.98639048
103KDM2B_26808549_Chip-Seq_K562_Human0.97865230
104GATA1_19941826_ChIP-Seq_K562_Human0.97719410
105P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97654455
106* P68_20966046_ChIP-Seq_HELA_Human0.95932274
107ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95024140
108FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94258753
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93736667
110HNF4A_19822575_ChIP-Seq_HepG2_Human0.92428034
111KDM2B_26808549_Chip-Seq_JURKAT_Human0.92136300
112DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91562244
113RUNX1_22412390_ChIP-Seq_EML_Mouse0.91107302
114ESR1_21235772_ChIP-Seq_MCF-7_Human0.90033955
115* BCOR_27268052_Chip-Seq_Bcells_Human0.89641470
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88563499
117EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88064805
118* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87874497
119NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87714430
120MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86747353
121TBX20_22080862_ChIP-Seq_HEART_Mouse0.86522446
122TBX20_22328084_ChIP-Seq_HEART_Mouse0.86522446
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86454966
124* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85895355
125GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85339700
126* TET1_21451524_ChIP-Seq_MESCs_Mouse0.85332958
127CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84982921

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.62357326
2MP0005360_urolithiasis4.85834677
3MP0005365_abnormal_bile_salt4.61783633
4MP0005085_abnormal_gallbladder_physiolo3.78362249
5MP0005083_abnormal_biliary_tract3.25936405
6MP0003252_abnormal_bile_duct2.98381820
7MP0001666_abnormal_nutrient_absorption2.74634988
8MP0009840_abnormal_foam_cell2.71252663
9MP0008875_abnormal_xenobiotic_pharmacok2.69780221
10MP0010329_abnormal_lipoprotein_level2.59468209
11MP0003300_gastrointestinal_ulcer2.45580112
12MP0003705_abnormal_hypodermis_morpholog2.40067004
13MP0003763_abnormal_thymus_physiology2.30171073
14MP0003303_peritoneal_inflammation2.19551195
15MP0005220_abnormal_exocrine_pancreas2.18870632
16MP0000609_abnormal_liver_physiology2.04118360
17MP0003191_abnormal_cellular_cholesterol2.01547872
18MP0003195_calcinosis1.88261213
19MP0008260_abnormal_autophagy1.87048488
20MP0008961_abnormal_basal_metabolism1.86554601
21MP0003806_abnormal_nucleotide_metabolis1.81178174
22MP0005332_abnormal_amino_acid1.81153268
23MP0001790_abnormal_immune_system1.74738010
24MP0005387_immune_system_phenotype1.74738010
25MP0009333_abnormal_splenocyte_physiolog1.69494566
26MP0003183_abnormal_peptide_metabolism1.66906282
27MP0002118_abnormal_lipid_homeostasis1.66610897
28MP0003868_abnormal_feces_composition1.66055184
29MP0000685_abnormal_immune_system1.65286052
30MP0001800_abnormal_humoral_immune1.65215782
31MP0009643_abnormal_urine_homeostasis1.56884626
32MP0009785_altered_susceptibility_to1.55717908
33MP0002138_abnormal_hepatobiliary_system1.55282843
34MP0005319_abnormal_enzyme/_coenzyme1.51660125
35MP0001835_abnormal_antigen_presentation1.49186889
36MP0004264_abnormal_extraembryonic_tissu1.48750888
37MP0001944_abnormal_pancreas_morphology1.40515116
38MP0009278_abnormal_bone_marrow1.39444225
39MP0003453_abnormal_keratinocyte_physiol1.38624732
40MP0002396_abnormal_hematopoietic_system1.38024078
41MP0005076_abnormal_cell_differentiation1.33471573
42MP0003091_abnormal_cell_migration1.32582091
43MP0002148_abnormal_hypersensitivity_rea1.30852380
44MP0000858_altered_metastatic_potential1.30363302
45MP0005409_darkened_coat_color1.29613825
46MP0000678_abnormal_parathyroid_gland1.26974872
47MP0002693_abnormal_pancreas_physiology1.26523956
48MP0002405_respiratory_system_inflammati1.26402467
49MP0004947_skin_inflammation1.26238818
50MP0004185_abnormal_adipocyte_glucose1.25830398
51MP0005670_abnormal_white_adipose1.25436676
52MP0004510_myositis1.24569678
53MP0002722_abnormal_immune_system1.24115026
54MP0000598_abnormal_liver_morphology1.21610466
55* MP0003436_decreased_susceptibility_to1.20831850
56MP0002078_abnormal_glucose_homeostasis1.20424130
57MP0003656_abnormal_erythrocyte_physiolo1.18893683
58MP0005584_abnormal_enzyme/coenzyme_acti1.18471188
59MP0001348_abnormal_lacrimal_gland1.17821570
60MP0002132_abnormal_respiratory_system1.14748442
61MP0009780_abnormal_chondrocyte_physiolo1.14367563
62MP0005058_abnormal_lysosome_morphology1.14362847
63MP0002452_abnormal_antigen_presenting1.12932042
64MP0004858_abnormal_nervous_system1.12696808
65MP0008438_abnormal_cutaneous_collagen1.12123111
66MP0003566_abnormal_cell_adhesion1.09673486
67MP0008469_abnormal_protein_level1.09226917
68MP0002909_abnormal_adrenal_gland1.08824961
69MP0002928_abnormal_bile_duct1.07820911
70MP0003172_abnormal_lysosome_physiology1.07444372
71MP0002998_abnormal_bone_remodeling1.06692785
72MP0001849_ear_inflammation1.06498475
73MP0001845_abnormal_inflammatory_respons1.06479694
74MP0000703_abnormal_thymus_morphology1.04316804
75MP0002723_abnormal_immune_serum1.02833989
76MP0000604_amyloidosis1.02413090
77MP0000003_abnormal_adipose_tissue1.01613287
78MP0010234_abnormal_vibrissa_follicle1.01104119
79MP0002796_impaired_skin_barrier0.98626543
80MP0002166_altered_tumor_susceptibility0.96815435
81MP0005464_abnormal_platelet_physiology0.94182368
82* MP0005000_abnormal_immune_tolerance0.92884927
83MP0002136_abnormal_kidney_physiology0.92850158
84MP0005334_abnormal_fat_pad0.91827191
85MP0001853_heart_inflammation0.91640864
86MP0009764_decreased_sensitivity_to0.90762518
87MP0001756_abnormal_urination0.90506320
88MP0010352_gastrointestinal_tract_polyps0.89856389
89MP0005636_abnormal_mineral_homeostasis0.89261210
90MP0001545_abnormal_hematopoietic_system0.88889326
91MP0005397_hematopoietic_system_phenotyp0.88889326
92MP0009642_abnormal_blood_homeostasis0.87803953
93MP0002089_abnormal_postnatal_growth/wei0.87685458
94MP0003866_abnormal_defecation0.86943581
95MP0005647_abnormal_sex_gland0.86728648
96MP0004381_abnormal_hair_follicle0.86435120
97MP0005023_abnormal_wound_healing0.86338069
98MP0004808_abnormal_hematopoietic_stem0.85784574
99MP0006054_spinal_hemorrhage0.84443456
100MP0005375_adipose_tissue_phenotype0.84024025
101MP0009931_abnormal_skin_appearance0.83637268
102MP0010155_abnormal_intestine_physiology0.83053590
103MP0005025_abnormal_response_to0.82516432
104MP0005448_abnormal_energy_balance0.82365130
105MP0002420_abnormal_adaptive_immunity0.81680138
106MP0005451_abnormal_body_composition0.81088026
107MP0002006_tumorigenesis0.80737543
108MP0000689_abnormal_spleen_morphology0.80324868
109MP0009763_increased_sensitivity_to0.80229836
110MP0008874_decreased_physiological_sensi0.80162807
111MP0004019_abnormal_vitamin_homeostasis0.80127542
112MP0001819_abnormal_immune_cell0.79099985
113MP0005621_abnormal_cell_physiology0.78633042
114MP0001873_stomach_inflammation0.78611617
115MP0000249_abnormal_blood_vessel0.77774769
116MP0002419_abnormal_innate_immunity0.77568900
117MP0004782_abnormal_surfactant_physiolog0.77127719
118MP0002398_abnormal_bone_marrow0.75643297
119MP0000716_abnormal_immune_system0.75304542
120MP0003959_abnormal_lean_body0.75110934
121MP0005310_abnormal_salivary_gland0.75074668
122MP0000013_abnormal_adipose_tissue0.74389412
123MP0001765_abnormal_ion_homeostasis0.72533877
124MP0002970_abnormal_white_adipose0.71774315
125MP0004043_abnormal_pH_regulation0.71214343
126MP0004130_abnormal_muscle_cell0.70423125
127MP0003045_fibrosis0.70301868
128MP0002933_joint_inflammation0.68818264
129MP0006082_CNS_inflammation0.64474743
130MP0005666_abnormal_adipose_tissue0.64298877
131MP0003075_altered_response_to0.63829768
132MP0002971_abnormal_brown_adipose0.63821068
133MP0005166_decreased_susceptibility_to0.63764977
134* MP0001533_abnormal_skeleton_physiology0.63569427
135MP0001764_abnormal_homeostasis0.62942325
136MP0002429_abnormal_blood_cell0.62745531
137MP0005671_abnormal_response_to0.62645502

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.08650756
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.71336705
3Xanthomatosis (HP:0000991)4.17733233
4Complement deficiency (HP:0004431)4.08499355
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.05426518
6Intrahepatic cholestasis (HP:0001406)4.03946756
7Agammaglobulinemia (HP:0004432)3.88193871
8Abnormality of the common coagulation pathway (HP:0010990)3.81404064
9Hypoglycemic coma (HP:0001325)3.64117065
10Prolonged partial thromboplastin time (HP:0003645)3.51503450
11Mitral stenosis (HP:0001718)3.51432200
12Ketosis (HP:0001946)3.50383982
13Abnormality of the intrinsic pathway (HP:0010989)3.45753826
14Hypobetalipoproteinemia (HP:0003563)3.31536686
15Colitis (HP:0002583)3.29235661
16Hyperlipoproteinemia (HP:0010980)3.24107571
17Cellulitis (HP:0100658)3.17595087
18Abnormality of complement system (HP:0005339)3.14246926
19Myocardial infarction (HP:0001658)3.13558632
20Eczematoid dermatitis (HP:0000976)3.06478809
21Papilloma (HP:0012740)3.03089534
22Verrucae (HP:0200043)3.03089534
23Ketoacidosis (HP:0001993)3.01586861
24Hypoglycemic seizures (HP:0002173)3.00600350
25Abnormality of sulfur amino acid metabolism (HP:0004339)2.89495357
26Abnormality of endocrine pancreas physiology (HP:0012093)2.87466691
27Abnormality of the pancreatic islet cells (HP:0006476)2.87466691
28Fat malabsorption (HP:0002630)2.85123498
29Late onset (HP:0003584)2.83461805
30Increased IgE level (HP:0003212)2.78188314
31Joint hemorrhage (HP:0005261)2.73779448
32Hyperinsulinemic hypoglycemia (HP:0000825)2.73307197
33Gastrointestinal inflammation (HP:0004386)2.72620749
34Abnormality of glutamine family amino acid metabolism (HP:0010902)2.71928262
35Inflammation of the large intestine (HP:0002037)2.60388615
36Hyperammonemia (HP:0001987)2.60088972
37Recurrent gram-negative bacterial infections (HP:0005420)2.56681187
38Abnormality of macrophages (HP:0004311)2.56395422
39Hypolipoproteinemia (HP:0010981)2.55412460
40Urinary glycosaminoglycan excretion (HP:0003541)2.52955765
41Mucopolysacchariduria (HP:0008155)2.52955765
42Obstructive sleep apnea (HP:0002870)2.52543821
43Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.51300020
44Abnormality of polysaccharide metabolism (HP:0011012)2.50033950
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.50033950
46Abnormality of mucopolysaccharide metabolism (HP:0011020)2.50033950
47Epidermoid cyst (HP:0200040)2.49691989
48Gout (HP:0001997)2.49076528
49Mediastinal lymphadenopathy (HP:0100721)2.47854007
50Recurrent bronchitis (HP:0002837)2.44468093
51Systemic lupus erythematosus (HP:0002725)2.42489488
52Flat acetabular roof (HP:0003180)2.42464375
53Vasculitis (HP:0002633)2.41393472
54Hypoalphalipoproteinemia (HP:0003233)2.39899608
55Abnormality of purine metabolism (HP:0004352)2.34267147
56Abnormality of the fingertips (HP:0001211)2.32446160
57Dysostosis multiplex (HP:0000943)2.29780870
58Gastrointestinal stroma tumor (HP:0100723)2.29481610
59Skin nodule (HP:0200036)2.28290168
60Recurrent viral infections (HP:0004429)2.27726587
61Thin bony cortex (HP:0002753)2.27509096
62Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.25335992
63Vertebral compression fractures (HP:0002953)2.24734127
64Restrictive lung disease (HP:0002091)2.23664165
65Symptomatic seizures (HP:0011145)2.23549184
66Conjugated hyperbilirubinemia (HP:0002908)2.17512393
67Gingival bleeding (HP:0000225)2.13750087
68Steatorrhea (HP:0002570)2.12227850
69Purpura (HP:0000979)2.11697539
70Panhypogammaglobulinemia (HP:0003139)2.10158185
71Abnormality of nucleobase metabolism (HP:0010932)2.08830206
72Hyperglycinuria (HP:0003108)2.08119901
73Obstructive lung disease (HP:0006536)2.07577080
74Chronic obstructive pulmonary disease (HP:0006510)2.07577080
75Hypercholesterolemia (HP:0003124)2.05214344
76Abnormality of fatty-acid metabolism (HP:0004359)2.04948992
77Back pain (HP:0003418)2.04906217
78Hyperglycemia (HP:0003074)2.02420644
79Recurrent sinusitis (HP:0011108)2.02414669
80Hyperglycinemia (HP:0002154)2.01843447
81Autoimmune thrombocytopenia (HP:0001973)2.00544753
82Protrusio acetabuli (HP:0003179)2.00325707
83Broad face (HP:0000283)2.00316521
84Abnormality of the Achilles tendon (HP:0005109)1.98905144
85Lymphopenia (HP:0001888)1.98833795
86Abnormality of serine family amino acid metabolism (HP:0010894)1.98352556
87Abnormality of glycine metabolism (HP:0010895)1.98352556
88Recurrent fungal infections (HP:0002841)1.97882255
89Recurrent bacterial skin infections (HP:0005406)1.97828845
90Recurrent abscess formation (HP:0002722)1.97431439
91Hyperbilirubinemia (HP:0002904)1.96994484
92Segmental peripheral demyelination/remyelination (HP:0003481)1.96688268
93Emphysema (HP:0002097)1.96570320
94Abnormal delayed hypersensitivity skin test (HP:0002963)1.95186901
95Ulnar bowing (HP:0003031)1.94978889
96Reticulocytosis (HP:0001923)1.94271241
97Long toe (HP:0010511)1.93388799
98Recurrent lower respiratory tract infections (HP:0002783)1.92005903
99Sensorimotor neuropathy (HP:0007141)1.91189526
100Loss of speech (HP:0002371)1.90955389
101Osteomyelitis (HP:0002754)1.90761636
102Abnormality of cells of the lymphoid lineage (HP:0012140)1.89745739
103Hemorrhage of the eye (HP:0011885)1.89149279
104Abnormality of the thoracic spine (HP:0100711)1.88769662
105Hypertensive crisis (HP:0100735)1.88465335
106Protuberant abdomen (HP:0001538)1.88346368
107Achilles tendon contracture (HP:0001771)1.88123127
108Hypertriglyceridemia (HP:0002155)1.87424884
109J-shaped sella turcica (HP:0002680)1.86787996
110Interstitial pulmonary disease (HP:0006530)1.86185420
111Hepatocellular carcinoma (HP:0001402)1.85695651
112Cervical subluxation (HP:0003308)1.85526423
113Epistaxis (HP:0000421)1.84472237
114Cerebral aneurysm (HP:0004944)1.84260966
115Aneurysm (HP:0002617)1.84172259
116Abnormal gallbladder physiology (HP:0012438)1.83742788
117Cholecystitis (HP:0001082)1.83742788
118Menorrhagia (HP:0000132)1.83654945
119Polycythemia (HP:0001901)1.83328347
120Sepsis (HP:0100806)1.83185937
121Gingivitis (HP:0000230)1.82656449
122Increased serum ferritin (HP:0003281)1.81730443
123Glomerulonephritis (HP:0000099)1.81488681
124Easy fatigability (HP:0003388)1.81019756
125Recurrent pneumonia (HP:0006532)1.80084541
126Hyperacusis (HP:0010780)1.79407879
127Abnormal platelet function (HP:0011869)1.79314020
128Impaired platelet aggregation (HP:0003540)1.79314020
129Thoracic kyphosis (HP:0002942)1.77913644
130Abnormal enzyme/coenzyme activity (HP:0012379)1.76619250
131Meningitis (HP:0001287)1.76062468
132Abnormality of transition element cation homeostasis (HP:0011030)1.74501404
133Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74495417
134Macroorchidism (HP:0000053)1.74188785
135B lymphocytopenia (HP:0010976)1.73979245
136Abnormality of B cell number (HP:0010975)1.73979245
137Pustule (HP:0200039)1.73441851
138Myositis (HP:0100614)1.72355297
139Abnormality of liposaccharide metabolism (HP:0010968)1.71769375
140Abnormality of glycosphingolipid metabolism (HP:0004343)1.71769375
141Abnormality of glycolipid metabolism (HP:0010969)1.71769375
142Abnormality of the peritoneum (HP:0002585)1.71677907
143Insulin resistance (HP:0000855)1.71631292
144Esophageal varix (HP:0002040)1.71410400
145Polygenic inheritance (HP:0010982)1.70947045
146Hand muscle atrophy (HP:0009130)1.70631566
147Malnutrition (HP:0004395)1.70450154
148Upper limb amyotrophy (HP:0009129)1.70289849
149Distal upper limb amyotrophy (HP:0007149)1.70289849
150Skin rash (HP:0000988)1.70093329
151Biconcave vertebral bodies (HP:0004586)1.69963833
152Spontaneous hematomas (HP:0007420)1.68837972
153Long palpebral fissure (HP:0000637)1.68398975
154Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.67697830
155Nephritis (HP:0000123)1.67585039
156Gastrointestinal infarctions (HP:0005244)1.67533853
157Abnormality of proline metabolism (HP:0010907)1.67442998
158Hydroxyprolinuria (HP:0003080)1.67442998
159Ectopia lentis (HP:0001083)1.66928843
160Exocrine pancreatic insufficiency (HP:0001738)1.66807273
161Skin ulcer (HP:0200042)1.66169452
162Abdominal distention (HP:0003270)1.66086212
163Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.65495462
164Elevated alkaline phosphatase (HP:0003155)1.64459222

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.32614768
2TRIB34.01385664
3PRPF4B3.45909486
4SIK13.44619495
5MAP4K13.35624202
6BCKDK3.00208805
7SMG12.83244679
8TAOK32.81543806
9RIPK42.58702614
10* ERN12.57982316
11PKN22.49924256
12EEF2K2.47089707
13FGFR42.38156976
14CDK122.22295166
15PTK61.86442550
16INSRR1.78189967
17GRK61.73099010
18IRAK41.61696325
19EPHB11.58725209
20TYK21.55606397
21TBK11.54345291
22JAK11.40300490
23SIK21.38916085
24BTK1.30798944
25SIK31.28872564
26LRRK21.28108024
27MAP3K71.23915823
28ICK1.23458071
29EPHA31.20637838
30CSF1R1.20399434
31ZAP701.20076845
32SYK1.15678395
33ARAF1.15590040
34EPHA21.12688730
35FLT31.09843861
36MTOR1.09782546
37CAMK1D1.09566344
38TAOK21.08933090
39STK101.06221642
40HIPK21.02269897
41LATS11.02157559
42PIK3CG1.01688150
43CAMK1G1.01571656
44MAP3K31.01301889
45MAPK111.00087532
46PASK0.99916769
47PDGFRA0.99000015
48PRKCH0.98754815
49JAK30.98616947
50BLK0.98382384
51MST1R0.98321982
52CSK0.97093156
53TAOK10.92354250
54RIPK10.90819385
55MAP3K130.89351775
56TESK10.89253282
57DYRK1B0.89094056
58NME20.87693556
59JAK20.86999580
60BMX0.86839165
61MAPK150.84718213
62SCYL20.83161784
63BRD40.82524469
64IKBKE0.81844585
65IRAK30.78992750
66PTK20.76565295
67CHUK0.75821971
68FGFR30.75486207
69FRK0.72199549
70MAP3K10.71959799
71MAPKAPK30.71939286
72HCK0.70355461
73PRKD20.69002668
74IRAK20.66656035
75TGFBR20.65408921
76PIM20.62818379
77MAP3K80.62730539
78PRKD10.62540478
79CDC42BPA0.62314478
80MAP2K30.61943904
81CDK40.61728964
82MAP2K20.61721518
83KDR0.61638063
84MAP3K140.60981378
85ITK0.58642384
86PRKD30.57997737
87TTN0.56880736
88TESK20.56714568
89LYN0.55827772
90RET0.55798096
91DDR20.54625720
92BRAF0.53033891
93MAP3K110.52596823
94MARK20.52373998
95MATK0.52034711
96RPS6KC10.51993498
97RPS6KL10.51993498
98MAPKAPK20.51853456
99PAK20.49788964
100CDK90.48818178
101MAPK120.46789044
102RPS6KA40.45785741
103MARK30.45447139
104RPS6KA20.42633964
105KSR20.42591796
106PRKCI0.41985717
107FES0.41890443
108MAP3K20.41086080
109KIT0.41027485
110NEK90.40913147
111CDK60.40767104
112MAP2K10.40529171
113ALK0.39792812
114PRKAA10.39718373
115EGFR0.39630371
116IKBKB0.39114117
117CDK70.38780982
118MAP3K90.36630328
119MAPK70.36073798
120LCK0.36014220
121MAPK40.35807619
122TNK20.35711228
123PDK10.35564203
124PDPK10.35213653
125SGK30.34666675
126PDGFRB0.34516697
127EIF2AK30.33299418
128ABL10.33067386

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.78555194
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.52293995
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.99574470
4Nitrogen metabolism_Homo sapiens_hsa009102.90019778
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.72268390
6Arginine biosynthesis_Homo sapiens_hsa002202.58159678
7Tryptophan metabolism_Homo sapiens_hsa003802.46406514
8Complement and coagulation cascades_Homo sapiens_hsa046102.46230981
9Fatty acid degradation_Homo sapiens_hsa000712.13696919
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03568448
11Allograft rejection_Homo sapiens_hsa053301.94431090
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89124022
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.88088254
14Selenocompound metabolism_Homo sapiens_hsa004501.83533490
15* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.82973173
16Autoimmune thyroid disease_Homo sapiens_hsa053201.82180683
17Staphylococcus aureus infection_Homo sapiens_hsa051501.72453345
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.69152368
19Graft-versus-host disease_Homo sapiens_hsa053321.68584611
20Fat digestion and absorption_Homo sapiens_hsa049751.67465227
21PPAR signaling pathway_Homo sapiens_hsa033201.65700753
22B cell receptor signaling pathway_Homo sapiens_hsa046621.60680228
23Lysine degradation_Homo sapiens_hsa003101.59939124
24Caffeine metabolism_Homo sapiens_hsa002321.57324439
25Asthma_Homo sapiens_hsa053101.51096834
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.49737153
27Influenza A_Homo sapiens_hsa051641.45780439
28Toxoplasmosis_Homo sapiens_hsa051451.44500888
29Fatty acid metabolism_Homo sapiens_hsa012121.41661868
30Notch signaling pathway_Homo sapiens_hsa043301.39537807
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38418023
32Bile secretion_Homo sapiens_hsa049761.37912706
33Primary immunodeficiency_Homo sapiens_hsa053401.36494502
34Butanoate metabolism_Homo sapiens_hsa006501.36016980
35Peroxisome_Homo sapiens_hsa041461.35567878
36Viral myocarditis_Homo sapiens_hsa054161.31754740
37Sulfur metabolism_Homo sapiens_hsa009201.30644975
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30166555
39ABC transporters_Homo sapiens_hsa020101.27588121
40Type I diabetes mellitus_Homo sapiens_hsa049401.24214991
41Histidine metabolism_Homo sapiens_hsa003401.23154293
42Tuberculosis_Homo sapiens_hsa051521.23104493
43Folate biosynthesis_Homo sapiens_hsa007901.22636381
44Phenylalanine metabolism_Homo sapiens_hsa003601.22433271
45Herpes simplex infection_Homo sapiens_hsa051681.20196319
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18627976
47VEGF signaling pathway_Homo sapiens_hsa043701.17624476
48Insulin resistance_Homo sapiens_hsa049311.16201552
49Hepatitis C_Homo sapiens_hsa051601.15796965
50Sulfur relay system_Homo sapiens_hsa041221.14827193
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.13781624
52Propanoate metabolism_Homo sapiens_hsa006401.13384244
53beta-Alanine metabolism_Homo sapiens_hsa004101.09934466
54Pancreatic cancer_Homo sapiens_hsa052121.09358977
55Hepatitis B_Homo sapiens_hsa051611.07462776
56Starch and sucrose metabolism_Homo sapiens_hsa005001.06698509
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99772546
58Measles_Homo sapiens_hsa051620.98819629
59Chemical carcinogenesis_Homo sapiens_hsa052040.97628889
60TNF signaling pathway_Homo sapiens_hsa046680.94403636
61T cell receptor signaling pathway_Homo sapiens_hsa046600.92778541
62Glycerolipid metabolism_Homo sapiens_hsa005610.92358675
63Biosynthesis of amino acids_Homo sapiens_hsa012300.90756786
64Hematopoietic cell lineage_Homo sapiens_hsa046400.89688238
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89034491
66Protein export_Homo sapiens_hsa030600.88756576
67Prion diseases_Homo sapiens_hsa050200.88303965
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87818499
69Renal cell carcinoma_Homo sapiens_hsa052110.85205661
70Apoptosis_Homo sapiens_hsa042100.84644979
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.84521015
72Pertussis_Homo sapiens_hsa051330.83742667
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83434359
74Pyruvate metabolism_Homo sapiens_hsa006200.82948346
75N-Glycan biosynthesis_Homo sapiens_hsa005100.81871798
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.81381233
77Tyrosine metabolism_Homo sapiens_hsa003500.80983494
78Prostate cancer_Homo sapiens_hsa052150.80092167
79HTLV-I infection_Homo sapiens_hsa051660.78112208
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.77203962
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76851698
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75748846
83Carbon metabolism_Homo sapiens_hsa012000.73369513
84Endometrial cancer_Homo sapiens_hsa052130.73362245
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.73227090
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.71659429
87Type II diabetes mellitus_Homo sapiens_hsa049300.70795392
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.69626494
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69435317
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68561592
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68388081
92Epstein-Barr virus infection_Homo sapiens_hsa051690.66056890
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65938452
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65540463
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.65237147
96Viral carcinogenesis_Homo sapiens_hsa052030.64799722
97ErbB signaling pathway_Homo sapiens_hsa040120.63681989
98Chemokine signaling pathway_Homo sapiens_hsa040620.63634537
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63617540
100Small cell lung cancer_Homo sapiens_hsa052220.63277694
101Choline metabolism in cancer_Homo sapiens_hsa052310.61361510
102Retinol metabolism_Homo sapiens_hsa008300.60289242
103Malaria_Homo sapiens_hsa051440.57891283
104Inositol phosphate metabolism_Homo sapiens_hsa005620.57511462
105Lysosome_Homo sapiens_hsa041420.57415817
106Amoebiasis_Homo sapiens_hsa051460.56976429
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.56864985
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56535983
109Thyroid cancer_Homo sapiens_hsa052160.56234130
110Osteoclast differentiation_Homo sapiens_hsa043800.56139935
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55689594
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.55401453
113Glioma_Homo sapiens_hsa052140.54248913
114Pancreatic secretion_Homo sapiens_hsa049720.53785089
115Arginine and proline metabolism_Homo sapiens_hsa003300.53645185
116Protein digestion and absorption_Homo sapiens_hsa049740.52676583
117GnRH signaling pathway_Homo sapiens_hsa049120.52512766
118HIF-1 signaling pathway_Homo sapiens_hsa040660.52242722
119Bladder cancer_Homo sapiens_hsa052190.51771415
120Chronic myeloid leukemia_Homo sapiens_hsa052200.50977140
121Glucagon signaling pathway_Homo sapiens_hsa049220.50415458
122Antigen processing and presentation_Homo sapiens_hsa046120.50014654
123mTOR signaling pathway_Homo sapiens_hsa041500.48784601
124Acute myeloid leukemia_Homo sapiens_hsa052210.48722725
125Endocytosis_Homo sapiens_hsa041440.48551018
126Estrogen signaling pathway_Homo sapiens_hsa049150.46635870
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45648395
128AMPK signaling pathway_Homo sapiens_hsa041520.43607422
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42959074
130Non-small cell lung cancer_Homo sapiens_hsa052230.42338418
131Vitamin digestion and absorption_Homo sapiens_hsa049770.41568779
132One carbon pool by folate_Homo sapiens_hsa006700.41198409
133Insulin signaling pathway_Homo sapiens_hsa049100.40615311
134Pentose phosphate pathway_Homo sapiens_hsa000300.40281412
135Thyroid hormone synthesis_Homo sapiens_hsa049180.39456274
136Leishmaniasis_Homo sapiens_hsa051400.39427676
137Galactose metabolism_Homo sapiens_hsa000520.37946122
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36895048
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36804768
140Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35763042
141Intestinal immune network for IgA production_Homo sapiens_hsa046720.35666849
142Renin-angiotensin system_Homo sapiens_hsa046140.34697982
143Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33700876
144Fructose and mannose metabolism_Homo sapiens_hsa000510.33171648
145Legionellosis_Homo sapiens_hsa051340.30318212
146Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29120159
147Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29086901
148Other glycan degradation_Homo sapiens_hsa005110.27425444
149Prolactin signaling pathway_Homo sapiens_hsa049170.26946426
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26745917
151Neurotrophin signaling pathway_Homo sapiens_hsa047220.26472601
152Central carbon metabolism in cancer_Homo sapiens_hsa052300.26460123

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