SYTL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.98168342
2axon ensheathment in central nervous system (GO:0032291)8.98168342
3fatty acid elongation (GO:0030497)6.06941550
4ensheathment of neurons (GO:0007272)6.00419678
5axon ensheathment (GO:0008366)6.00419678
6myelination (GO:0042552)5.99916759
7intestinal epithelial cell development (GO:0060576)5.50577516
8striated muscle atrophy (GO:0014891)5.42088325
9long-chain fatty acid biosynthetic process (GO:0042759)5.17978692
10negative regulation of neurotransmitter secretion (GO:0046929)5.08819299
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.99681024
12cilium or flagellum-dependent cell motility (GO:0001539)4.85323966
13axonemal dynein complex assembly (GO:0070286)4.75824446
14cilium movement (GO:0003341)4.72255496
15muscle atrophy (GO:0014889)4.71011243
16presynaptic membrane organization (GO:0097090)4.57307904
17ear development (GO:0043583)4.54251980
18presynaptic membrane assembly (GO:0097105)4.53844616
19negative regulation of neurotransmitter transport (GO:0051589)4.49068584
20negative regulation of organelle assembly (GO:1902116)4.26820790
21myelin maintenance (GO:0043217)4.22402500
22skeletal muscle adaptation (GO:0043501)4.13510018
23oligodendrocyte differentiation (GO:0048709)4.13241788
24apical protein localization (GO:0045176)4.06940265
25glycerophospholipid catabolic process (GO:0046475)4.00284555
26epithelial cilium movement (GO:0003351)3.95590680
27neuronal action potential propagation (GO:0019227)3.94542581
28regulation of establishment of cell polarity (GO:2000114)3.86997605
29asymmetric protein localization (GO:0008105)3.86932473
30regulation of establishment or maintenance of cell polarity (GO:0032878)3.84690887
31neuron cell-cell adhesion (GO:0007158)3.83623943
32negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.78639766
33axoneme assembly (GO:0035082)3.76226554
34establishment of mitochondrion localization (GO:0051654)3.74715111
35cholesterol biosynthetic process (GO:0006695)3.69187023
36negative regulation of protein localization to cell surface (GO:2000009)3.67858670
37photoreceptor cell differentiation (GO:0046530)3.63204940
38eye photoreceptor cell differentiation (GO:0001754)3.63204940
39positive regulation of fatty acid beta-oxidation (GO:0032000)3.63189016
40diterpenoid biosynthetic process (GO:0016102)3.51666951
41negative regulation of cytosolic calcium ion concentration (GO:0051481)3.48851727
42astrocyte development (GO:0014002)3.47172881
43peptidyl-tyrosine autophosphorylation (GO:0038083)3.44593676
44substantia nigra development (GO:0021762)3.41645313
45regulation of collateral sprouting (GO:0048670)3.39504565
46hepatocyte apoptotic process (GO:0097284)3.33891135
47transmission of nerve impulse (GO:0019226)3.31264087
48motile cilium assembly (GO:0044458)3.29364322
49L-amino acid import (GO:0043092)3.26860778
50sterol biosynthetic process (GO:0016126)3.24262159
51vagina development (GO:0060068)3.23374144
52adult walking behavior (GO:0007628)3.22215309
53peripheral nervous system axon ensheathment (GO:0032292)3.19789493
54myelination in peripheral nervous system (GO:0022011)3.19789493
55virion attachment to host cell (GO:0019062)3.19555710
56adhesion of symbiont to host cell (GO:0044650)3.19555710
57positive regulation of keratinocyte differentiation (GO:0045618)3.14165416
58negative regulation of axonogenesis (GO:0050771)3.13083676
59creatine metabolic process (GO:0006600)3.12254542
60positive regulation of action potential (GO:0045760)3.11541097
61response to redox state (GO:0051775)3.10504769
62regulation of fatty acid beta-oxidation (GO:0031998)3.10209655
63nerve growth factor signaling pathway (GO:0038180)3.09498362
64cellular response to epinephrine stimulus (GO:0071872)3.08233273
65auditory receptor cell differentiation (GO:0042491)3.08152471
66membrane assembly (GO:0071709)3.07296659
67positive regulation of fatty acid oxidation (GO:0046321)3.06782700
68cerebral cortex radially oriented cell migration (GO:0021799)3.05706439
69female genitalia development (GO:0030540)3.04593747
70membrane tubulation (GO:0097320)3.02877582
71cerebellar granule cell differentiation (GO:0021707)3.02413560
72regulation of cell proliferation involved in kidney development (GO:1901722)3.01727974
73protein palmitoylation (GO:0018345)3.01320434
74long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.97916927
75response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.90988301
76import into cell (GO:0098657)2.89912545
77negative regulation of sodium ion transport (GO:0010766)2.88973426
78positive regulation of oligodendrocyte differentiation (GO:0048714)2.86149641
79long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.85104838
80magnesium ion transport (GO:0015693)2.84574926
81L-fucose catabolic process (GO:0042355)2.81790031
82fucose catabolic process (GO:0019317)2.81790031
83L-fucose metabolic process (GO:0042354)2.81790031
84neuronal ion channel clustering (GO:0045161)2.81749158
85peripheral nervous system development (GO:0007422)2.81706970
86regulation of voltage-gated calcium channel activity (GO:1901385)2.81616406
87glutamate secretion (GO:0014047)2.80619063
88regulation of synaptic vesicle exocytosis (GO:2000300)2.80464438
89response to methylmercury (GO:0051597)2.80271049
90behavioral response to nicotine (GO:0035095)2.77408038
91gamma-aminobutyric acid signaling pathway (GO:0007214)2.77254343
92detection of temperature stimulus involved in sensory perception (GO:0050961)2.76841035
93detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.76841035
94response to epinephrine (GO:0071871)2.75467864
95synaptic vesicle exocytosis (GO:0016079)2.74803713
96regulation of hippo signaling (GO:0035330)2.74769027
97left/right axis specification (GO:0070986)2.74087013
98isoprenoid biosynthetic process (GO:0008299)2.72543744
99regulation of protein glycosylation (GO:0060049)2.71598609
100axon development (GO:0061564)2.70120781
101TOR signaling (GO:0031929)2.69660814
102mesonephros development (GO:0001823)2.67533910
103glycosylceramide metabolic process (GO:0006677)2.66788415
104regulation of acrosome reaction (GO:0060046)2.66787531
105regulation of action potential (GO:0098900)2.66011738
106negative regulation of kidney development (GO:0090185)2.64817840
107norepinephrine metabolic process (GO:0042415)2.64468786
108regulation of interleukin-13 production (GO:0032656)2.64084578
109amyloid precursor protein metabolic process (GO:0042982)2.63312627
110positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.62912316
111synaptic vesicle maturation (GO:0016188)2.61368592
112neuronal action potential (GO:0019228)2.60873586
113adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.59521006
114negative regulation of JUN kinase activity (GO:0043508)2.58093832
115calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.57338544
116regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.57182912
117negative regulation of synaptic transmission, GABAergic (GO:0032229)2.56703640
118neuron recognition (GO:0008038)2.56591134
119flavonoid metabolic process (GO:0009812)2.55958539
120negative regulation of axon extension (GO:0030517)2.55168584
121cardiac right ventricle morphogenesis (GO:0003215)2.55012049
122L-serine transport (GO:0015825)2.55001848
123regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.54413974
124regulation of cilium movement (GO:0003352)2.54412492
125response to lipoprotein particle (GO:0055094)2.53669580
126negative regulation of keratinocyte proliferation (GO:0010839)2.53276821
127neuron remodeling (GO:0016322)2.52571901
128protein localization to endosome (GO:0036010)2.51574442
129limb bud formation (GO:0060174)2.50490026
130phosphatidylinositol 3-kinase signaling (GO:0014065)2.50318421
131cellular response to catecholamine stimulus (GO:0071870)2.48368512
132cellular response to monoamine stimulus (GO:0071868)2.48368512
133fatty-acyl-CoA biosynthetic process (GO:0046949)2.47507635
134vitamin transmembrane transport (GO:0035461)2.47349986
135piRNA metabolic process (GO:0034587)2.47112253
136embryonic retina morphogenesis in camera-type eye (GO:0060059)2.47042917
137regulation of interleukin-5 production (GO:0032674)2.46875847
138positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.45798618
139N-glycan processing (GO:0006491)2.45779923
140nitric oxide biosynthetic process (GO:0006809)2.45711421
141glycosphingolipid biosynthetic process (GO:0006688)2.43889165
142establishment of protein localization to Golgi (GO:0072600)2.43250829
143myoblast fusion (GO:0007520)2.43092104
144neurotransmitter catabolic process (GO:0042135)2.42345302
145insulin-like growth factor receptor signaling pathway (GO:0048009)2.41860901
146uterus development (GO:0060065)2.41661060
147cytoskeletal anchoring at plasma membrane (GO:0007016)2.41654283
148Golgi to endosome transport (GO:0006895)2.41260328
149membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.40423179
150prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.40406253
151Golgi to plasma membrane protein transport (GO:0043001)2.38892466
152cyclic nucleotide catabolic process (GO:0009214)2.38044890
153dendrite morphogenesis (GO:0048813)2.35547784
154regulation of cell communication by electrical coupling (GO:0010649)2.35510000
155embryonic camera-type eye morphogenesis (GO:0048596)2.35357144
156negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.35355731
157regulation of short-term neuronal synaptic plasticity (GO:0048172)2.35219703
158negative regulation of synaptic transmission (GO:0050805)2.35019698
159sympathetic nervous system development (GO:0048485)2.34645514
160protein localization to synapse (GO:0035418)2.34480227
161regulation of protein localization to cell surface (GO:2000008)2.33301688
162neuron-neuron synaptic transmission (GO:0007270)2.32661264
163sulfate transmembrane transport (GO:1902358)2.32655668
164behavioral response to ethanol (GO:0048149)2.32297648
165microtubule bundle formation (GO:0001578)2.32181116
166axonal fasciculation (GO:0007413)2.32042109
167sphingoid metabolic process (GO:0046519)2.31397387
168negative regulation of inclusion body assembly (GO:0090084)2.30563762
169dendritic spine morphogenesis (GO:0060997)2.30273075
170fatty-acyl-CoA metabolic process (GO:0035337)2.29984167
171actin filament depolymerization (GO:0030042)2.29903443
172peptidyl-cysteine modification (GO:0018198)2.29714669
173GPI anchor metabolic process (GO:0006505)2.29657438
174response to monoamine (GO:0071867)2.29183971
175keratinocyte development (GO:0003334)2.28443521
176negative regulation of Ras GTPase activity (GO:0034261)2.28276648
177macroautophagy (GO:0016236)2.27062705
178negative regulation of systemic arterial blood pressure (GO:0003085)2.26180638
179regulation of axon extension involved in axon guidance (GO:0048841)2.24429066
180ventricular system development (GO:0021591)2.24067149
181pharyngeal system development (GO:0060037)2.23052620
182epithelial cell maturation (GO:0002070)2.22581753
183positive regulation of epidermal cell differentiation (GO:0045606)2.18675423
184response to electrical stimulus (GO:0051602)2.18053785
185regulation of sodium ion transmembrane transporter activity (GO:2000649)2.17335785
186response to food (GO:0032094)2.15657456
187oligosaccharide biosynthetic process (GO:0009312)2.15436628
188regulation of alkaline phosphatase activity (GO:0010692)2.15250521
189cornea development in camera-type eye (GO:0061303)2.14516564
190regulation of fatty acid oxidation (GO:0046320)2.14408326
191cilium organization (GO:0044782)2.12967842
192terpenoid biosynthetic process (GO:0016114)2.12151427
193action potential (GO:0001508)2.11359615
194retrograde transport, vesicle recycling within Golgi (GO:0000301)2.11214822

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human3.98388597
2ESR1_21235772_ChIP-Seq_MCF-7_Human3.81298942
3GBX2_23144817_ChIP-Seq_PC3_Human3.77902674
4ESR2_21235772_ChIP-Seq_MCF-7_Human3.45263449
5EZH2_22144423_ChIP-Seq_EOC_Human2.66215509
6TAF15_26573619_Chip-Seq_HEK293_Human2.62337531
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.52735092
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52448442
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45073442
10SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.33220644
11* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.32049267
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.19274212
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.19274212
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12569843
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10095558
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.07620422
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03396927
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03085115
19ESR1_15608294_ChIP-ChIP_MCF-7_Human1.98438804
20FOXM1_26456572_ChIP-Seq_MCF-7_Human1.98111059
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.97175502
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.93023392
23OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.92435339
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88504614
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87733999
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86623706
27DROSHA_22980978_ChIP-Seq_HELA_Human1.86251610
28ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.85070029
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84910894
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.84770932
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84405588
32AR_21572438_ChIP-Seq_LNCaP_Human1.81106861
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78031214
34VDR_22108803_ChIP-Seq_LS180_Human1.77156313
35TDRD3_21172665_ChIP-Seq_MCF-7_Human1.76459969
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73536945
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.72383452
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.69939048
39RUNX1_27514584_Chip-Seq_MCF-7_Human1.63592153
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61913501
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60297717
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.60262262
43ER_23166858_ChIP-Seq_MCF-7_Human1.60140156
44CDX2_20551321_ChIP-Seq_CACO-2_Human1.57893589
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56468591
46RARB_27405468_Chip-Seq_BRAIN_Mouse1.53573298
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.53146823
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52475656
49FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51094232
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.48656078
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48066948
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38686298
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37855205
54REST_21632747_ChIP-Seq_MESCs_Mouse1.37399478
55P300_19829295_ChIP-Seq_ESCs_Human1.37291546
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36691356
57GATA3_24758297_ChIP-Seq_MCF-7_Human1.35898046
58CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35712713
59SMAD4_21799915_ChIP-Seq_A2780_Human1.35588841
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34576204
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.33353332
62STAT3_23295773_ChIP-Seq_U87_Human1.31221198
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30723713
64* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30016439
65ZNF274_21170338_ChIP-Seq_K562_Hela1.26901029
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25845740
67FOXA1_25552417_ChIP-Seq_VCAP_Human1.25027710
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24278126
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23668324
70BCAT_22108803_ChIP-Seq_LS180_Human1.23389552
71FUS_26573619_Chip-Seq_HEK293_Human1.22488174
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21646607
73* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20984546
74STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19791069
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19390477
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18542733
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17405223
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17330694
79* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16734368
80AR_25329375_ChIP-Seq_VCAP_Human1.13378859
81TCF4_23295773_ChIP-Seq_U87_Human1.13365969
82REST_18959480_ChIP-ChIP_MESCs_Mouse1.13303132
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.12663813
84AHR_22903824_ChIP-Seq_MCF-7_Human1.12116858
85RNF2_27304074_Chip-Seq_NSC_Mouse1.11968106
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11586871
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11586871
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11358226
89RXR_22108803_ChIP-Seq_LS180_Human1.10829957
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.08973914
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08407269
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.08342455
93AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08297718
94WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07045481
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.05409906
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.05236528
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04801843
98TP53_16413492_ChIP-PET_HCT116_Human1.02658946
99AR_19668381_ChIP-Seq_PC3_Human1.02451272
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02433979
101PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02345734
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02167837
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02167837
104* EP300_21415370_ChIP-Seq_HL-1_Mouse1.01814594
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00001933
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99948489
107* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99393812
108TP53_18474530_ChIP-ChIP_U2OS_Human0.98453219
109LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98326916
110FOXA2_19822575_ChIP-Seq_HepG2_Human0.98231069
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97792671
112* CJUN_26792858_Chip-Seq_BT549_Human0.97290812
113HOXB7_26014856_ChIP-Seq_BT474_Human0.97238414
114EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96302733
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.95824219
116TAL1_26923725_Chip-Seq_HPCs_Mouse0.95656439
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.95144915
118FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94361172
119SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94254682
120RUNX2_22187159_ChIP-Seq_PCA_Human0.94013921
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93870556
122KLF5_25053715_ChIP-Seq_YYC3_Human0.93501651
123PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92791220
124SALL1_21062744_ChIP-ChIP_HESCs_Human0.92425379
125TRIM28_21343339_ChIP-Seq_HEK293_Human0.92269615
126P300_18555785_Chip-Seq_ESCs_Mouse0.91506256
127LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91248534
128NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90479866
129TCF4_22108803_ChIP-Seq_LS180_Human0.90201609
130IGF1R_20145208_ChIP-Seq_DFB_Human0.89543660
131KDM2B_26808549_Chip-Seq_REH_Human0.89473379
132CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88859169
133MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87700597
134SMAD4_21741376_ChIP-Seq_EPCs_Human0.87425910
135E2F1_18555785_Chip-Seq_ESCs_Mouse0.87357119
136TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87193015
137FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.86712552
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86618310
139PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86265258
140P53_22387025_ChIP-Seq_ESCs_Mouse0.86235484
141TBL1_22424771_ChIP-Seq_293T_Human0.85756309
142JUN_21703547_ChIP-Seq_K562_Human0.85645906
143RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85107426
144STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85008942
145CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84341917

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.72064540
2MP0000920_abnormal_myelination4.55675878
3MP0004270_analgesia4.35703808
4MP0004859_abnormal_synaptic_plasticity3.47226668
5MP0003950_abnormal_plasma_membrane2.83768166
6MP0005171_absent_coat_pigmentation2.82455385
7MP0002272_abnormal_nervous_system2.70589904
8MP0003329_amyloid_beta_deposits2.65404681
9MP0002064_seizures2.57826980
10MP0001486_abnormal_startle_reflex2.57508895
11MP0005646_abnormal_pituitary_gland2.49972900
12MP0009046_muscle_twitch2.48809121
13MP0003635_abnormal_synaptic_transmissio2.43967092
14MP0000427_abnormal_hair_cycle2.43289694
15MP0002734_abnormal_mechanical_nocicepti2.41936992
16MP0003690_abnormal_glial_cell2.36668448
17MP0004742_abnormal_vestibular_system2.35588268
18MP0003183_abnormal_peptide_metabolism2.32606263
19MP0004885_abnormal_endolymph2.29046710
20MP0009745_abnormal_behavioral_response2.28670835
21MP0000538_abnormal_urinary_bladder2.26008807
22MP0000569_abnormal_digit_pigmentation2.19942558
23MP0001485_abnormal_pinna_reflex2.18324867
24MP0001873_stomach_inflammation2.17982986
25MP0004264_abnormal_extraembryonic_tissu2.16435496
26MP0001905_abnormal_dopamine_level2.10016431
27MP0001529_abnormal_vocalization2.05828887
28MP0000778_abnormal_nervous_system2.03415244
29MP0002876_abnormal_thyroid_physiology1.97869666
30MP0002735_abnormal_chemical_nociception1.95945761
31MP0003634_abnormal_glial_cell1.92226674
32MP0004142_abnormal_muscle_tone1.90178648
33MP0008875_abnormal_xenobiotic_pharmacok1.87008613
34MP0008872_abnormal_physiological_respon1.85602126
35MP0002160_abnormal_reproductive_system1.84713038
36MP0002909_abnormal_adrenal_gland1.82748905
37MP0003136_yellow_coat_color1.81310184
38MP0001968_abnormal_touch/_nociception1.79773313
39MP0002572_abnormal_emotion/affect_behav1.76331715
40MP0003787_abnormal_imprinting1.75141557
41MP0002063_abnormal_learning/memory/cond1.73520127
42MP0001440_abnormal_grooming_behavior1.72715604
43MP0002229_neurodegeneration1.66705774
44MP0005409_darkened_coat_color1.65239152
45MP0002009_preneoplasia1.64290041
46MP0003879_abnormal_hair_cell1.61388738
47MP0001970_abnormal_pain_threshold1.60718889
48MP0003632_abnormal_nervous_system1.60485945
49MP0005423_abnormal_somatic_nervous1.59353609
50MP0004858_abnormal_nervous_system1.57518654
51MP0008569_lethality_at_weaning1.57142912
52MP0000372_irregular_coat_pigmentation1.56080420
53MP0002067_abnormal_sensory_capabilities1.54389667
54MP0000955_abnormal_spinal_cord1.52793219
55MP0000462_abnormal_digestive_system1.52299133
56MP0002733_abnormal_thermal_nociception1.52010150
57MP0010386_abnormal_urinary_bladder1.49308637
58MP0010678_abnormal_skin_adnexa1.48892849
59MP0001299_abnormal_eye_distance/1.48415632
60MP0005310_abnormal_salivary_gland1.46000249
61MP0002736_abnormal_nociception_after1.45709441
62MP0000383_abnormal_hair_follicle1.45369849
63MP0002882_abnormal_neuron_morphology1.42576419
64MP0005623_abnormal_meninges_morphology1.39595999
65MP0004924_abnormal_behavior1.37276125
66MP0005386_behavior/neurological_phenoty1.37276125
67MP0002098_abnormal_vibrissa_morphology1.36424017
68MP0002653_abnormal_ependyma_morphology1.33171230
69MP0005410_abnormal_fertilization1.32284126
70MP0002066_abnormal_motor_capabilities/c1.31566321
71MP0003936_abnormal_reproductive_system1.30948024
72MP0001765_abnormal_ion_homeostasis1.29432638
73MP0010234_abnormal_vibrissa_follicle1.27149814
74MP0003631_nervous_system_phenotype1.25215946
75MP0001963_abnormal_hearing_physiology1.23752616
76MP0008004_abnormal_stomach_pH1.23306203
77MP0000604_amyloidosis1.22631930
78MP0005451_abnormal_body_composition1.21079967
79MP0004147_increased_porphyrin_level1.20412378
80MP0004381_abnormal_hair_follicle1.19509533
81MP0004145_abnormal_muscle_electrophysio1.17264396
82MP0001501_abnormal_sleep_pattern1.16546526
83MP0001919_abnormal_reproductive_system1.16518927
84MP0004043_abnormal_pH_regulation1.16313357
85MP0009384_cardiac_valve_regurgitation1.14417203
86MP0005075_abnormal_melanosome_morpholog1.13973343
87MP0002184_abnormal_innervation1.12670094
88MP0000747_muscle_weakness1.12448282
89MP0005551_abnormal_eye_electrophysiolog1.12191438
90MP0000534_abnormal_ureter_morphology1.10778250
91MP0002752_abnormal_somatic_nervous1.10494832
92MP0003866_abnormal_defecation1.07205434
93MP0000627_abnormal_mammary_gland1.06892944
94MP0003633_abnormal_nervous_system1.06486021
95MP0000537_abnormal_urethra_morphology1.05219660
96MP0002249_abnormal_larynx_morphology1.02667102
97MP0004134_abnormal_chest_morphology1.00941278
98MP0002108_abnormal_muscle_morphology1.00586250
99MP0009780_abnormal_chondrocyte_physiolo0.99776438
100MP0005408_hypopigmentation0.99540085
101MP0003942_abnormal_urinary_system0.93512439
102MP0001346_abnormal_lacrimal_gland0.92182280
103MP0005389_reproductive_system_phenotype0.90326887
104MP0001984_abnormal_olfaction0.89950379
105MP0008260_abnormal_autophagy0.88043946
106MP0004811_abnormal_neuron_physiology0.86661780
107MP0003938_abnormal_ear_development0.86430276
108MP0001756_abnormal_urination0.85366172
109* MP0000470_abnormal_stomach_morphology0.85253513
110MP0001348_abnormal_lacrimal_gland0.82996112
111MP0004782_abnormal_surfactant_physiolog0.82869882
112MP0002168_other_aberrant_phenotype0.82670010
113MP0002751_abnormal_autonomic_nervous0.81860283
114MP0002152_abnormal_brain_morphology0.81164769
115MP0002557_abnormal_social/conspecific_i0.80560836
116MP0002796_impaired_skin_barrier0.79905372
117MP0005076_abnormal_cell_differentiation0.79737258
118MP0006276_abnormal_autonomic_nervous0.79394641
119MP0001851_eye_inflammation0.78490984
120MP0003123_paternal_imprinting0.77772475
121MP0005174_abnormal_tail_pigmentation0.77740355
122MP0003195_calcinosis0.76875786
123MP0000751_myopathy0.76592014
124MP0004233_abnormal_muscle_weight0.76115557
125MP0005503_abnormal_tendon_morphology0.74552014
126MP0001177_atelectasis0.74035316
127MP0005083_abnormal_biliary_tract0.73982254
128MP0000026_abnormal_inner_ear0.73975603
129MP0000613_abnormal_salivary_gland0.73869812
130MP0000678_abnormal_parathyroid_gland0.72419670
131MP0002234_abnormal_pharynx_morphology0.72179950
132MP0001661_extended_life_span0.69867362
133MP0000579_abnormal_nail_morphology0.69406208
134MP0001502_abnormal_circadian_rhythm0.68678434
135MP0005085_abnormal_gallbladder_physiolo0.67244493
136MP0005645_abnormal_hypothalamus_physiol0.66810298
137MP0008789_abnormal_olfactory_epithelium0.66559426
138MP0002822_catalepsy0.65323264
139MP0000647_abnormal_sebaceous_gland0.63497329
140* MP0001664_abnormal_digestion0.63492990
141MP0008438_abnormal_cutaneous_collagen0.63373853
142MP0001943_abnormal_respiration0.63017749
143MP0000762_abnormal_tongue_morphology0.62615570
144MP0005195_abnormal_posterior_eye0.61946147
145MP0000566_synostosis0.61660178
146MP0008874_decreased_physiological_sensi0.60542969
147MP0004036_abnormal_muscle_relaxation0.59305715
148MP0004185_abnormal_adipocyte_glucose0.58822338
149MP0003937_abnormal_limbs/digits/tail_de0.58440159
150MP0002295_abnormal_pulmonary_circulatio0.56977124
151MP0000749_muscle_degeneration0.56733955
152MP0006082_CNS_inflammation0.54674273

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.15119856
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.15119856
3Sensory axonal neuropathy (HP:0003390)5.63242344
4Neurofibrillary tangles (HP:0002185)5.32958176
5J-shaped sella turcica (HP:0002680)5.07504708
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.84867173
7Parakeratosis (HP:0001036)4.68034646
8Abnormality of the corticospinal tract (HP:0002492)4.67231106
9Absent frontal sinuses (HP:0002688)4.43548350
10Absent/shortened dynein arms (HP:0200106)4.38079556
11Dynein arm defect of respiratory motile cilia (HP:0012255)4.38079556
12Abnormal respiratory motile cilium physiology (HP:0012261)4.22480894
13Abnormal ciliary motility (HP:0012262)4.15849084
14Abnormal respiratory motile cilium morphology (HP:0005938)4.06877292
15Abnormal respiratory epithelium morphology (HP:0012253)4.06877292
16Peripheral hypomyelination (HP:0007182)4.01193078
17Myokymia (HP:0002411)4.00833143
18Cerebral inclusion bodies (HP:0100314)3.95586015
19Pancreatic cysts (HP:0001737)3.94661715
20Rhinitis (HP:0012384)3.80918509
21Onion bulb formation (HP:0003383)3.73320627
22Supranuclear gaze palsy (HP:0000605)3.71037266
23Spastic gait (HP:0002064)3.65673177
24Akinesia (HP:0002304)3.63377800
25Insidious onset (HP:0003587)3.62959669
26Termporal pattern (HP:0011008)3.62959669
27Atonic seizures (HP:0010819)3.49286523
28Focal motor seizures (HP:0011153)3.48286301
29Concave nail (HP:0001598)3.45907790
30Pancreatic fibrosis (HP:0100732)3.44432259
31Dysmetria (HP:0001310)3.43905124
32Abnormality of midbrain morphology (HP:0002418)3.30463549
33Molar tooth sign on MRI (HP:0002419)3.30463549
34Cystic liver disease (HP:0006706)3.26088149
35Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.25297288
36True hermaphroditism (HP:0010459)3.22738779
37Chronic bronchitis (HP:0004469)3.21840127
38Aplasia/Hypoplasia of the tongue (HP:0010295)3.20311397
39Intention tremor (HP:0002080)3.19279694
40Cerebral hypomyelination (HP:0006808)3.13577347
41Scanning speech (HP:0002168)3.13537509
42Decreased circulating renin level (HP:0003351)3.12663461
43Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.04284629
44Bronchiectasis (HP:0002110)3.01365557
45Epileptic encephalopathy (HP:0200134)2.99401140
46Thickened helices (HP:0000391)2.94349051
47Alacrima (HP:0000522)2.91321906
48Abnormal auditory evoked potentials (HP:0006958)2.90074682
49Amelogenesis imperfecta (HP:0000705)2.88439730
50Hyperactive renin-angiotensin system (HP:0000841)2.80563889
51Abnormality of the frontal sinuses (HP:0002687)2.76985424
52Lip pit (HP:0100267)2.70342133
53Ankle clonus (HP:0011448)2.69609175
54Pheochromocytoma (HP:0002666)2.67704801
55Slow saccadic eye movements (HP:0000514)2.65928929
56Abnormality of the renal cortex (HP:0011035)2.64509872
57Chronic hepatic failure (HP:0100626)2.63993277
58Nephronophthisis (HP:0000090)2.62174581
59Tubular atrophy (HP:0000092)2.61081633
60Abnormality of glycolysis (HP:0004366)2.60017488
61Increased serum pyruvate (HP:0003542)2.60017488
62Deformed sella turcica (HP:0002681)2.55379051
63Autoamputation (HP:0001218)2.52832152
64Abnormality of the renal medulla (HP:0100957)2.49878378
65Genetic anticipation (HP:0003743)2.49525840
66Focal seizures (HP:0007359)2.47790576
67Calf muscle hypertrophy (HP:0008981)2.46825058
68Retinal dysplasia (HP:0007973)2.46203909
69Stridor (HP:0010307)2.44157919
70Microglossia (HP:0000171)2.42763128
71Abnormality of renin-angiotensin system (HP:0000847)2.40379551
72Hyperventilation (HP:0002883)2.37935166
73Breast carcinoma (HP:0003002)2.36409467
74Abnormality of the sella turcica (HP:0002679)2.35202500
75Neuroendocrine neoplasm (HP:0100634)2.34168299
76Action tremor (HP:0002345)2.32915788
77Congenital ichthyosiform erythroderma (HP:0007431)2.29620731
78Febrile seizures (HP:0002373)2.29334924
79Cerebral hemorrhage (HP:0001342)2.29229510
80Progressive cerebellar ataxia (HP:0002073)2.26256909
81Premature skin wrinkling (HP:0100678)2.25698633
82Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.24594465
83Hyperaldosteronism (HP:0000859)2.23583413
84Metabolic alkalosis (HP:0200114)2.23337122
85Septate vagina (HP:0001153)2.22352529
86Spastic paraparesis (HP:0002313)2.21572183
87Absent speech (HP:0001344)2.20196626
88Leukodystrophy (HP:0002415)2.19516508
89Decreased lacrimation (HP:0000633)2.18965841
90Polydipsia (HP:0001959)2.18865859
91Abnormal drinking behavior (HP:0030082)2.18865859
92Anteriorly placed anus (HP:0001545)2.18405816
93Foot dorsiflexor weakness (HP:0009027)2.17355972
94Aplasia involving bones of the upper limbs (HP:0009823)2.17143139
95Aplasia of the phalanges of the hand (HP:0009802)2.17143139
96Aplasia involving bones of the extremities (HP:0009825)2.17143139
97Blue irides (HP:0000635)2.16457036
98Partial agenesis of the corpus callosum (HP:0001338)2.15401682
99Infantile muscular hypotonia (HP:0008947)2.15085938
100Increased circulating renin level (HP:0000848)2.14879198
101Gaze-evoked nystagmus (HP:0000640)2.14455670
102Segmental peripheral demyelination/remyelination (HP:0003481)2.13707960
103Infertility (HP:0000789)2.13638125
104Lower limb muscle weakness (HP:0007340)2.13567988
105Broad-based gait (HP:0002136)2.11607866
106Medial flaring of the eyebrow (HP:0010747)2.10746272
107Decreased motor nerve conduction velocity (HP:0003431)2.10352944
108Curly hair (HP:0002212)2.08881371
109Steppage gait (HP:0003376)2.07062652
110Megalencephaly (HP:0001355)2.05344572
111Hammertoe (HP:0001765)2.04906125
112Gowers sign (HP:0003391)2.04732585
113Cone-rod dystrophy (HP:0000548)2.04201639
114Hypoplastic pelvis (HP:0008839)2.02299703
115Type II lissencephaly (HP:0007260)2.01751770
116Relative macrocephaly (HP:0004482)2.00899187
117Hypoplasia of the iris (HP:0007676)1.99786142
118Hyporeflexia of lower limbs (HP:0002600)1.99598915
119Muscle hypertrophy of the lower extremities (HP:0008968)1.98013929
120Fetal akinesia sequence (HP:0001989)1.97445749
121Absent septum pellucidum (HP:0001331)1.97032134
122Hyperkalemia (HP:0002153)1.96405463
123Hypomagnesemia (HP:0002917)1.96373478
124Split foot (HP:0001839)1.95821733
125Gait imbalance (HP:0002141)1.95610760
126Postaxial foot polydactyly (HP:0001830)1.94073574
127White forelock (HP:0002211)1.93819838
128Abnormality of the foot musculature (HP:0001436)1.93420182
129Synostosis involving the elbow (HP:0003938)1.93388848
130Humeroradial synostosis (HP:0003041)1.93388848
131Clumsiness (HP:0002312)1.92434272
132Diminished movement (HP:0002374)1.92234794
133Nasal polyposis (HP:0100582)1.90524687
134Bronchitis (HP:0012387)1.90090616
135Urinary urgency (HP:0000012)1.89592886
136Generalized hypopigmentation of hair (HP:0011358)1.89430043
137Generalized myoclonic seizures (HP:0002123)1.88932411
138Vaginal atresia (HP:0000148)1.88692765
139Distal sensory impairment (HP:0002936)1.87829646
140Muscle fiber splitting (HP:0003555)1.86666351
141Coronal craniosynostosis (HP:0004440)1.86137272
142Keratoconus (HP:0000563)1.85921872
143Increased corneal curvature (HP:0100692)1.85921872
144Male pseudohermaphroditism (HP:0000037)1.84941496
145Renal dysplasia (HP:0000110)1.83178282
146Furrowed tongue (HP:0000221)1.83049706
147CNS hypomyelination (HP:0003429)1.82922507
148Dialeptic seizures (HP:0011146)1.82727411
149Germ cell neoplasia (HP:0100728)1.82459345
150Prostate neoplasm (HP:0100787)1.81859578
151Macroorchidism (HP:0000053)1.81450662
152Genital tract atresia (HP:0001827)1.81318672
153Poor speech (HP:0002465)1.79356432
154Barrel-shaped chest (HP:0001552)1.78813552
155Nonprogressive disorder (HP:0003680)1.78720469
156Cupped ear (HP:0000378)1.78408412
157Dysdiadochokinesis (HP:0002075)1.78342089
158Hypoplastic ischia (HP:0003175)1.77450425
159Bell-shaped thorax (HP:0001591)1.77254535
160Micronodular cirrhosis (HP:0001413)1.76949546
161Aplasia/Hypoplasia of the tibia (HP:0005772)1.76631786
162Adrenal hypoplasia (HP:0000835)1.76423528
163Patchy hypopigmentation of hair (HP:0011365)1.75767665
164Absence seizures (HP:0002121)1.75226930
165Hypokalemic alkalosis (HP:0001949)1.75209370
166Ulnar claw (HP:0001178)1.74688200
167Widely spaced teeth (HP:0000687)1.74612273
168Spastic tetraparesis (HP:0001285)1.74484768
169Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.74426198
170Congenital hepatic fibrosis (HP:0002612)1.73817228
171Protruding tongue (HP:0010808)1.72987284
172Congenital primary aphakia (HP:0007707)1.71898840
173Congenital stationary night blindness (HP:0007642)1.71543226
174Poor coordination (HP:0002370)1.71476226
175Sclerocornea (HP:0000647)1.70568567
176Testicular neoplasm (HP:0010788)1.70345873
177Occipital encephalocele (HP:0002085)1.70020504
178Flat acetabular roof (HP:0003180)1.69501569
179Thyroid-stimulating hormone excess (HP:0002925)1.69158795
180Abdominal distention (HP:0003270)1.67625469
181Pigmentary retinal degeneration (HP:0001146)1.67028081
182Testicular atrophy (HP:0000029)1.65882263
183Papillary thyroid carcinoma (HP:0002895)1.64538855
184Absent rod-and cone-mediated responses on ERG (HP:0007688)1.63389392
185Anencephaly (HP:0002323)1.62710262
186Prolonged QT interval (HP:0001657)1.62410706
187Renal cortical cysts (HP:0000803)1.61923894
188Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.61472111
189Aplasia of the musculature (HP:0100854)1.60624551

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.71297051
2FRK4.78328764
3OXSR14.74857050
4CDK193.41329836
5TRIB32.96808462
6EPHB12.79625405
7EPHA22.71404317
8CASK2.55735569
9BCR2.52951826
10WNK42.52930802
11MAPKAPK32.46320925
12PRPF4B2.32877521
13MET2.31940864
14PKN22.27167186
15EPHA42.11963669
16WNK12.09746809
17RPS6KB22.06056746
18SCYL22.01621763
19TNK22.00054414
20FGFR21.95761107
21TNIK1.93954031
22PAK61.83215831
23PKN11.79050764
24LIMK11.76112643
25MAPKAPK51.70432839
26NTRK11.62591857
27SIK11.61403286
28PRKCI1.58412594
29NEK61.58312140
30MAP3K121.55863421
31ICK1.54768239
32CHUK1.50887223
33CSNK1G31.48679847
34ADRBK21.48177979
35CSNK1A1L1.47235859
36ROCK21.45688183
37UHMK11.45238978
38CAMK2B1.39060521
39EEF2K1.37607233
40FER1.34493757
41MST41.33679159
42PBK1.29505515
43MAP2K21.29285415
44PNCK1.28700086
45CSNK1G21.26423188
46GRK11.25231410
47CAMKK11.24974906
48PRKD31.24228545
49FGR1.22629447
50MUSK1.18707134
51AKT31.17427253
52PAK31.17305093
53CSNK1G11.16070200
54RIPK11.15593042
55NTRK31.15376521
56ERBB41.12977132
57CAMK2D1.12771563
58PINK11.11403336
59MAP2K11.10533516
60MAP3K91.09727890
61CDK51.06879850
62SGK4941.06307739
63SGK2231.06307739
64CLK11.05060222
65ARAF1.01826508
66CDK141.01005470
67TESK21.00715064
68TAOK30.98656444
69STK380.96126622
70PRKCZ0.95995501
71CDK150.93341386
72MAP3K40.93008572
73RPS6KB10.92974868
74CAMK2A0.92277188
75PRKCQ0.91754317
76CDK180.90968193
77TYRO30.90377493
78CAMK2G0.89707450
79MAP3K130.89281738
80TXK0.87799238
81KSR20.86901650
82MARK20.85920144
83CDK11A0.82209002
84ACVR1B0.81983994
85CAMK10.81738148
86MARK10.80587031
87NUAK10.79771719
88PDPK10.79458839
89PHKG10.78344282
90PHKG20.78344282
91RPS6KA20.78241332
92ILK0.75762909
93SGK20.74976908
94DAPK20.72365469
95TRPM70.71710988
96MINK10.69453951
97ADRBK10.68684061
98PRKCE0.67547419
99CAMK1G0.65353347
100MTOR0.65025244
101MAP2K70.64275548
102PTK2B0.64002929
103FYN0.62745947
104STK110.61949760
105BMX0.60596067
106MYLK0.60019070
107MAP3K20.59103681
108PRKCH0.56864156
109PLK20.56238416
110MOS0.55216174
111MAPK130.55043805
112ITK0.54467609
113ERBB20.54290997
114NTRK20.52329318
115LMTK20.51882933
116MST1R0.51422648
117DDR20.49629155
118PDK10.49192469
119PRKD10.47968402
120PRKD20.47326688
121STK38L0.46883847
122CAMK1D0.46783009
123IKBKB0.46063323
124CAMKK20.43797687
125MAP3K70.43183833
126SGK30.43139176
127PRKG10.42450622
128CSNK1A10.41674228
129BMPR20.41326545
130DMPK0.41125221
131PIK3CA0.40831797
132BMPR1B0.40816882
133ROCK10.40663531
134RET0.40103908
135MAPK70.38647025
136MAPK80.36036753
137PDGFRB0.35726053
138PRKAA20.35251973
139MELK0.35036173
140LRRK20.34958939
141PRKAA10.34884047
142GRK50.33664438
143PRKACB0.33486876
144IKBKE0.33450073
145CSNK1D0.33228029
146PRKCA0.33224139
147TRIM280.33001778
148SMG10.32678426
149DYRK1A0.32490060
150SGK10.30943473
151INSR0.29089419
152MAPK150.28356480
153MAPK100.27207957
154PRKCG0.25655337
155DYRK20.25507873
156RAF10.25361754
157PRKACA0.24864401

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.00509173
2Steroid biosynthesis_Homo sapiens_hsa001003.45539281
3Fatty acid elongation_Homo sapiens_hsa000622.97896877
4Ether lipid metabolism_Homo sapiens_hsa005652.66668093
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.63059138
6Nitrogen metabolism_Homo sapiens_hsa009102.18640655
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.14684766
8Axon guidance_Homo sapiens_hsa043602.02035320
9Collecting duct acid secretion_Homo sapiens_hsa049661.80747437
10ABC transporters_Homo sapiens_hsa020101.79497873
11Synaptic vesicle cycle_Homo sapiens_hsa047211.77667325
12Glutamatergic synapse_Homo sapiens_hsa047241.75443758
13Caffeine metabolism_Homo sapiens_hsa002321.65067428
14GABAergic synapse_Homo sapiens_hsa047271.64857375
15Nicotine addiction_Homo sapiens_hsa050331.62478394
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.61497287
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.57978802
18Serotonergic synapse_Homo sapiens_hsa047261.56192588
19Morphine addiction_Homo sapiens_hsa050321.55779777
20Sphingolipid metabolism_Homo sapiens_hsa006001.53821916
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.51851226
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.50744973
23Chemical carcinogenesis_Homo sapiens_hsa052041.49688471
24Oxidative phosphorylation_Homo sapiens_hsa001901.46534723
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.44421796
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43558256
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42496782
28Vibrio cholerae infection_Homo sapiens_hsa051101.40656938
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39398375
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.39352230
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37972937
32Olfactory transduction_Homo sapiens_hsa047401.35584413
33Salivary secretion_Homo sapiens_hsa049701.35119861
34Long-term depression_Homo sapiens_hsa047301.33707587
35Circadian entrainment_Homo sapiens_hsa047131.33531461
36Gastric acid secretion_Homo sapiens_hsa049711.33109796
37Sulfur metabolism_Homo sapiens_hsa009201.31594246
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.26065698
39Linoleic acid metabolism_Homo sapiens_hsa005911.22662306
40Endometrial cancer_Homo sapiens_hsa052131.19918819
41Longevity regulating pathway - mammal_Homo sapiens_hsa042111.18924615
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.18302597
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18279304
44Dopaminergic synapse_Homo sapiens_hsa047281.17274328
45Renal cell carcinoma_Homo sapiens_hsa052111.15588981
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14296017
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13029592
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12336538
49Tryptophan metabolism_Homo sapiens_hsa003801.11490256
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10022703
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09845806
52Long-term potentiation_Homo sapiens_hsa047201.09700614
53Autoimmune thyroid disease_Homo sapiens_hsa053201.05610891
54Amphetamine addiction_Homo sapiens_hsa050311.05175316
55Taste transduction_Homo sapiens_hsa047421.03972958
56Vascular smooth muscle contraction_Homo sapiens_hsa042701.02988224
57ErbB signaling pathway_Homo sapiens_hsa040121.02203589
58beta-Alanine metabolism_Homo sapiens_hsa004101.01784002
59Alzheimers disease_Homo sapiens_hsa050101.01370586
60Tight junction_Homo sapiens_hsa045300.99864062
61Cholinergic synapse_Homo sapiens_hsa047250.99754114
62Estrogen signaling pathway_Homo sapiens_hsa049150.99014266
63Retinol metabolism_Homo sapiens_hsa008300.98975325
64Bile secretion_Homo sapiens_hsa049760.98376918
65Ras signaling pathway_Homo sapiens_hsa040140.98263085
66Dorso-ventral axis formation_Homo sapiens_hsa043200.98122894
67mTOR signaling pathway_Homo sapiens_hsa041500.96884775
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.94128980
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93813351
70Endocytosis_Homo sapiens_hsa041440.92538513
71Renin secretion_Homo sapiens_hsa049240.92323987
72Rheumatoid arthritis_Homo sapiens_hsa053230.90579357
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89347895
74Thyroid cancer_Homo sapiens_hsa052160.89306297
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89295405
76Cocaine addiction_Homo sapiens_hsa050300.88282847
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.88264342
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86108106
79Ovarian steroidogenesis_Homo sapiens_hsa049130.85977004
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84297936
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83385175
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83292888
83Oxytocin signaling pathway_Homo sapiens_hsa049210.83017773
84Vitamin B6 metabolism_Homo sapiens_hsa007500.83013263
85Parkinsons disease_Homo sapiens_hsa050120.82776650
86Insulin resistance_Homo sapiens_hsa049310.80655313
87Cardiac muscle contraction_Homo sapiens_hsa042600.80242058
88AMPK signaling pathway_Homo sapiens_hsa041520.78631246
89Histidine metabolism_Homo sapiens_hsa003400.77364050
90Pancreatic secretion_Homo sapiens_hsa049720.76771642
91cAMP signaling pathway_Homo sapiens_hsa040240.76488265
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75569447
93Melanoma_Homo sapiens_hsa052180.73477115
94Butanoate metabolism_Homo sapiens_hsa006500.73040430
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72402245
96Calcium signaling pathway_Homo sapiens_hsa040200.71727718
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.71594110
98Lysine degradation_Homo sapiens_hsa003100.71399166
99Gap junction_Homo sapiens_hsa045400.71087306
100Insulin secretion_Homo sapiens_hsa049110.70697894
101Glioma_Homo sapiens_hsa052140.69921486
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69144567
103Phototransduction_Homo sapiens_hsa047440.68775754
104Protein export_Homo sapiens_hsa030600.68503793
105VEGF signaling pathway_Homo sapiens_hsa043700.67026976
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66815954
107GnRH signaling pathway_Homo sapiens_hsa049120.65626426
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65540820
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.64959873
110Mineral absorption_Homo sapiens_hsa049780.61689304
111MAPK signaling pathway_Homo sapiens_hsa040100.61644209
112ECM-receptor interaction_Homo sapiens_hsa045120.59559326
113Hippo signaling pathway_Homo sapiens_hsa043900.58992702
114Choline metabolism in cancer_Homo sapiens_hsa052310.58884992
115Hepatitis C_Homo sapiens_hsa051600.57878123
116Type II diabetes mellitus_Homo sapiens_hsa049300.57614560
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57323007
118Thyroid hormone synthesis_Homo sapiens_hsa049180.56751297
119Glycerolipid metabolism_Homo sapiens_hsa005610.54989125
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54781484
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54707863
122Dilated cardiomyopathy_Homo sapiens_hsa054140.53873358
123Propanoate metabolism_Homo sapiens_hsa006400.53195194
124Melanogenesis_Homo sapiens_hsa049160.52507034
125Prolactin signaling pathway_Homo sapiens_hsa049170.50724563
126T cell receptor signaling pathway_Homo sapiens_hsa046600.49883249
127Phagosome_Homo sapiens_hsa041450.49014565
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48755724
129Rap1 signaling pathway_Homo sapiens_hsa040150.48566616
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47094671
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46816740
132Arachidonic acid metabolism_Homo sapiens_hsa005900.45954807
133Inositol phosphate metabolism_Homo sapiens_hsa005620.44024053
134Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41396553
135Arginine and proline metabolism_Homo sapiens_hsa003300.41171664
136Salmonella infection_Homo sapiens_hsa051320.41087353
137Asthma_Homo sapiens_hsa053100.40166822
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38206152
139Chemokine signaling pathway_Homo sapiens_hsa040620.37535038
140Hedgehog signaling pathway_Homo sapiens_hsa043400.36793924
141Fatty acid biosynthesis_Homo sapiens_hsa000610.36465700

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