SYTL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.88727843
2proline metabolic process (GO:0006560)6.43725227
3embryonic process involved in female pregnancy (GO:0060136)5.96563063
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.88800928
5negative regulation of cell killing (GO:0031342)5.88800928
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.79452192
7DNA deamination (GO:0045006)5.71966529
8desmosome organization (GO:0002934)5.45595217
9leukocyte aggregation (GO:0070486)4.99655854
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.97803579
11transcription from mitochondrial promoter (GO:0006390)4.91106667
12negative thymic T cell selection (GO:0045060)4.82926351
13negative T cell selection (GO:0043383)4.82405709
14regulation of B cell receptor signaling pathway (GO:0050855)4.79492346
15positive regulation of protein homooligomerization (GO:0032464)4.78727771
16establishment of apical/basal cell polarity (GO:0035089)4.75655875
17protein retention in ER lumen (GO:0006621)4.71766451
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.56707359
19viral transcription (GO:0019083)4.53955613
20regulation of gamma-delta T cell activation (GO:0046643)4.43031268
21positive thymic T cell selection (GO:0045059)4.41851624
22GDP-mannose metabolic process (GO:0019673)4.41425231
23tolerance induction (GO:0002507)4.39539520
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.35074347
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.35074347
26hemidesmosome assembly (GO:0031581)4.33702679
27keratinization (GO:0031424)4.31374358
28negative regulation of lymphocyte mediated immunity (GO:0002707)4.27976803
29oxidative demethylation (GO:0070989)4.24582696
30translational termination (GO:0006415)4.24231880
31detection of bacterium (GO:0016045)4.22543168
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.21943891
33protein targeting to ER (GO:0045047)4.12180378
34regulation of protein homooligomerization (GO:0032462)4.11454291
35thymic T cell selection (GO:0045061)4.10251288
36T cell selection (GO:0045058)4.08186418
37cotranslational protein targeting to membrane (GO:0006613)4.07154248
38detection of other organism (GO:0098543)4.05832856
39response to interleukin-15 (GO:0070672)3.99858198
40positive T cell selection (GO:0043368)3.98705378
41negative regulation of erythrocyte differentiation (GO:0045647)3.95341126
42establishment of protein localization to endoplasmic reticulum (GO:0072599)3.92732515
43protein localization to endoplasmic reticulum (GO:0070972)3.85356568
44positive regulation by symbiont of host defense response (GO:0052509)3.84460610
45modulation by symbiont of host defense response (GO:0052031)3.84460610
46modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.84460610
47modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.84460610
48positive regulation by organism of defense response of other organism involved in symbiotic interact3.84460610
49modulation by symbiont of host immune response (GO:0052553)3.84460610
50intestinal cholesterol absorption (GO:0030299)3.84454136
51negative regulation of T cell mediated immunity (GO:0002710)3.83933852
52replication fork processing (GO:0031297)3.83462542
53establishment of monopolar cell polarity (GO:0061162)3.83448536
54establishment or maintenance of monopolar cell polarity (GO:0061339)3.83448536
55formation of translation preinitiation complex (GO:0001731)3.82545972
56B cell receptor signaling pathway (GO:0050853)3.81922579
57regulation of water loss via skin (GO:0033561)3.81455521
58activated T cell proliferation (GO:0050798)3.81096577
59translational elongation (GO:0006414)3.79674321
60cellular response to interleukin-15 (GO:0071350)3.77861486
61negative regulation of stress fiber assembly (GO:0051497)3.74776371
62negative regulation of leukocyte mediated immunity (GO:0002704)3.74660784
63mitotic G1 DNA damage checkpoint (GO:0031571)3.72884843
64regulation of B cell differentiation (GO:0045577)3.69490647
65hair cycle (GO:0042633)3.69415463
66molting cycle (GO:0042303)3.69415463
67establishment of skin barrier (GO:0061436)3.65725729
68neutrophil activation involved in immune response (GO:0002283)3.65424471
69positive regulation of T cell mediated cytotoxicity (GO:0001916)3.64613308
70ribosomal small subunit assembly (GO:0000028)3.61647386
71antigen processing and presentation via MHC class Ib (GO:0002475)3.60401719
72regulation of translational fidelity (GO:0006450)3.59473016
73regulation of T cell mediated cytotoxicity (GO:0001914)3.59320945
74cellular extravasation (GO:0045123)3.57432502
75regulation of integrin activation (GO:0033623)3.55965279
76poly(A)+ mRNA export from nucleus (GO:0016973)3.55141716
77positive regulation of B cell differentiation (GO:0045579)3.54735963
78Golgi transport vesicle coating (GO:0048200)3.54590548
79COPI coating of Golgi vesicle (GO:0048205)3.54590548
80antigen processing and presentation of endogenous antigen (GO:0019883)3.53757529
81positive regulation of granulocyte differentiation (GO:0030854)3.53110576
82positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.48024318
83immunoglobulin mediated immune response (GO:0016064)3.47421797
84viral life cycle (GO:0019058)3.45813005
85response to muramyl dipeptide (GO:0032495)3.42068166
86translational initiation (GO:0006413)3.41833779
87negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.41246938
88defense response to protozoan (GO:0042832)3.40983526
89regulation of alpha-beta T cell proliferation (GO:0046640)3.40113171
90T cell migration (GO:0072678)3.39197136
91response to peptidoglycan (GO:0032494)3.33110390
92mitotic G1/S transition checkpoint (GO:0044819)3.33061896
93negative regulation of phagocytosis (GO:0050765)3.32158984
94negative regulation of interleukin-6 production (GO:0032715)3.31480984
95regulation of regulatory T cell differentiation (GO:0045589)3.31008212
96neutrophil activation (GO:0042119)3.30188218
97mitochondrial DNA metabolic process (GO:0032042)3.30148485
98nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.28441529
99response to protozoan (GO:0001562)3.25846559
100sulfur amino acid catabolic process (GO:0000098)3.25325544
101regulation of tolerance induction (GO:0002643)3.23840521
102maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.19418883
103glutamine family amino acid biosynthetic process (GO:0009084)3.18006345
104cellular response to zinc ion (GO:0071294)3.16442538
105macrophage activation involved in immune response (GO:0002281)3.15830362
106regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.15526371
107mast cell activation (GO:0045576)3.15466300
108trophectodermal cell differentiation (GO:0001829)3.15269989
109negative regulation of Ras GTPase activity (GO:0034261)3.14334935
110G1 DNA damage checkpoint (GO:0044783)3.13716952
111COPII vesicle coating (GO:0048208)3.13414892
112negative regulation of innate immune response (GO:0045824)3.12431394
113negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.11371739
114respiratory burst (GO:0045730)3.11128528
115response to type I interferon (GO:0034340)3.10214621
116negative regulation of cell cycle arrest (GO:0071157)3.10024178
117regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.09422813
118regulation of T cell tolerance induction (GO:0002664)3.08976541
119leukocyte degranulation (GO:0043299)3.08574927
120regulation of antigen processing and presentation (GO:0002577)3.08077801
121antigen receptor-mediated signaling pathway (GO:0050851)3.07927369
122positive regulation of tolerance induction (GO:0002645)3.06658593
123positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.05983493
124positive regulation of antigen processing and presentation (GO:0002579)3.05774111
125negative regulation of glycoprotein biosynthetic process (GO:0010561)3.05729517
126ribosomal small subunit biogenesis (GO:0042274)3.05640247
127embryonic placenta development (GO:0001892)3.05178618
128type I interferon signaling pathway (GO:0060337)3.04974615
129cellular response to type I interferon (GO:0071357)3.04974615
130regulation of interferon-beta biosynthetic process (GO:0045357)3.04674981
131phospholipid scrambling (GO:0017121)3.02516419
132mucosal-associated lymphoid tissue development (GO:0048537)3.02209065
133Peyers patch development (GO:0048541)3.02209065
134dosage compensation (GO:0007549)3.01307769
135regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.00920667
136regulation of natural killer cell mediated immunity (GO:0002715)3.00920667
137positive regulation of protein oligomerization (GO:0032461)3.00027602
138cellular protein complex disassembly (GO:0043624)2.98767236
139myeloid cell activation involved in immune response (GO:0002275)2.97387620
140regulation of mast cell degranulation (GO:0043304)2.96511437
141negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.96302891
142positive regulation by host of viral transcription (GO:0043923)2.95505082
143negative regulation of adaptive immune response (GO:0002820)2.95173018
144mRNA cleavage (GO:0006379)2.95011235
145negative regulation of interleukin-12 production (GO:0032695)2.94722087
146detection of external biotic stimulus (GO:0098581)2.91298891
147negative regulation of T-helper cell differentiation (GO:0045623)2.91130676
148negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.91130676
149regulation of leukocyte mediated cytotoxicity (GO:0001910)2.90428244
150keratinocyte differentiation (GO:0030216)2.87380322
151regulation of gamma-delta T cell differentiation (GO:0045586)2.83659253
152granulocyte activation (GO:0036230)2.83409689
153negative regulation of protein oligomerization (GO:0032460)2.82957943
154regulation of dendritic cell antigen processing and presentation (GO:0002604)2.82509352
155positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.81777875
156positive regulation of histone deacetylation (GO:0031065)2.81439487
157T cell receptor signaling pathway (GO:0050852)2.80554160
158regulation of T cell mediated immunity (GO:0002709)2.79654578
159regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.79632479
160negative regulation of fatty acid biosynthetic process (GO:0045717)2.79567607
161face development (GO:0060324)2.78565029
162positive regulation of interleukin-17 production (GO:0032740)2.78514733
163mast cell activation involved in immune response (GO:0002279)2.78246548
164mast cell degranulation (GO:0043303)2.78246548
165regulation of myeloid leukocyte mediated immunity (GO:0002886)2.78117929
166glandular epithelial cell development (GO:0002068)2.77632918
167apoptotic process involved in morphogenesis (GO:0060561)2.76507294
168base-excision repair, AP site formation (GO:0006285)2.73200006
169exocrine pancreas development (GO:0031017)2.73115515
170retinoic acid receptor signaling pathway (GO:0048384)2.72832634
171protein complex disassembly (GO:0043241)2.71817939
172anatomical structure regression (GO:0060033)2.71122536
173protein targeting to membrane (GO:0006612)2.70995690
174intestinal epithelial cell development (GO:0060576)2.70010460
175somatic diversification of immune receptors via somatic mutation (GO:0002566)2.69173167
176somatic hypermutation of immunoglobulin genes (GO:0016446)2.69173167
177regulation of cholesterol homeostasis (GO:2000188)2.68226185
178regulation of podosome assembly (GO:0071801)2.67982348
179interferon-gamma secretion (GO:0072643)2.66049094
180ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.65983378
181multicellular organismal water homeostasis (GO:0050891)2.62152832
182negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.61544248
183negative regulation of tumor necrosis factor production (GO:0032720)2.61507093
184regulation of protein oligomerization (GO:0032459)2.61105661
185negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.60598394
186negative regulation of JAK-STAT cascade (GO:0046426)2.60368820
187columnar/cuboidal epithelial cell development (GO:0002066)2.59573433
188positive regulation of gamma-delta T cell activation (GO:0046645)2.57702176
189base-excision repair (GO:0006284)2.57381437
190positive regulation of lamellipodium assembly (GO:0010592)2.57144640
191activation of Rac GTPase activity (GO:0032863)2.55191005

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.57995863
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.01378446
3RUNX_20019798_ChIP-Seq_JUKART_Human2.94728327
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.94603097
5VDR_21846776_ChIP-Seq_THP-1_Human2.77101359
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.76931798
7SCL_19346495_ChIP-Seq_HPC-7_Human2.64874569
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.61133689
9MYC_22102868_ChIP-Seq_BL_Human2.53972328
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.26629807
11LXR_22292898_ChIP-Seq_THP-1_Human2.21825900
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.20488565
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11939318
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.09102892
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.08881153
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.03632824
17ZNF263_19887448_ChIP-Seq_K562_Human2.01147798
18GATA3_27048872_Chip-Seq_THYMUS_Human1.93478751
19SPI1_23127762_ChIP-Seq_K562_Human1.92618771
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.87296766
21* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82957030
22RACK7_27058665_Chip-Seq_MCF-7_Human1.77831969
23STAT4_19710469_ChIP-ChIP_TH1__Mouse1.77765922
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75760837
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.74921691
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.73021303
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69693531
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68216314
29* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.65962852
30LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.65599340
31TCF7_22412390_ChIP-Seq_EML_Mouse1.65218171
32GATA3_26560356_Chip-Seq_TH2_Human1.64810453
33KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.62706585
34KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.62706585
35KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.62706585
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61837190
37VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.61651193
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.61276781
39* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.61194915
40UTX_26944678_Chip-Seq_JUKART_Human1.57649435
41* MAF_26560356_Chip-Seq_TH1_Human1.56980520
42* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.56864157
43* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56613024
44KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.54816037
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52291211
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49254201
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.48561496
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48007116
49* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47038152
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.46902028
51* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45099236
52VDR_24763502_ChIP-Seq_THP-1_Human1.44954396
53GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39310432
54KDM2B_26808549_Chip-Seq_DND41_Human1.38482608
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.37992879
56P300_27268052_Chip-Seq_Bcells_Human1.37845450
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37305713
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36895567
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36879015
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36370552
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36024610
62MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.33991881
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.33139692
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32332700
65CTCF_21964334_ChIP-Seq_BJAB-B_Human1.31341568
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30371056
67GATA1_19941826_ChIP-Seq_K562_Human1.29914985
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29616407
69BCOR_27268052_Chip-Seq_Bcells_Human1.29263776
70CIITA_25753668_ChIP-Seq_RAJI_Human1.28931758
71* IRF8_22096565_ChIP-ChIP_GC-B_Human1.28847002
72SA1_27219007_Chip-Seq_ERYTHROID_Human1.28601557
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.28130848
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27068810
75CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26384674
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25491428
77TET1_21451524_ChIP-Seq_MESCs_Mouse1.24506555
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24315221
79* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24213460
80VDR_24787735_ChIP-Seq_THP-1_Human1.24164388
81PPARA_22158963_ChIP-Seq_LIVER_Mouse1.23935865
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21941097
83* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20436265
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20344472
85* RUNX1_22412390_ChIP-Seq_EML_Mouse1.20287884
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19243954
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19203804
88* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18842442
89RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18219290
90RXR_22158963_ChIP-Seq_LIVER_Mouse1.16895198
91CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16292779
92* MAF_26560356_Chip-Seq_TH2_Human1.15637311
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15003583
94MYB_26560356_Chip-Seq_TH2_Human1.15002544
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14668225
96YY1_22570637_ChIP-Seq_MALME-3M_Human1.14399099
97PHF8_20622854_ChIP-Seq_HELA_Human1.14172460
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14068458
99DROSHA_22980978_ChIP-Seq_HELA_Human1.13876528
100NOTCH1_21737748_ChIP-Seq_TLL_Human1.13610330
101SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13481988
102SMC4_20622854_ChIP-Seq_HELA_Human1.12771790
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12576810
104P68_20966046_ChIP-Seq_HELA_Human1.12526804
105* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11687531
106KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11672842
107CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11435475
108ESR2_21235772_ChIP-Seq_MCF-7_Human1.11247676
109RARB_24833708_ChIP-Seq_LIVER_Mouse1.10960882
110* ATF3_27146783_Chip-Seq_COLON_Human1.10881346
111GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09802300
112* ETS1_21867929_ChIP-Seq_TH2_Mouse1.09689115
113SPI1_20517297_ChIP-Seq_HL60_Human1.09488832
114BCL6_27268052_Chip-Seq_Bcells_Human1.09227363
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08832732
116CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08761329
117ELF1_20517297_ChIP-Seq_JURKAT_Human1.08050066
118* MYB_26560356_Chip-Seq_TH1_Human1.07513379
119KDM2B_26808549_Chip-Seq_JURKAT_Human1.07214868
120STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06955849
121* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06805447
122SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05375400
123ESR1_21235772_ChIP-Seq_MCF-7_Human1.05220890
124STAT1_20625510_ChIP-Seq_HELA_Human1.05209808
125GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04762513
126MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04622070
127SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04570759
128SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02697448
129TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02382836
130RUNX1_27514584_Chip-Seq_MCF-7_Human1.02378828
131DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02294103
132RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00694796
133CTCF_26484167_Chip-Seq_Bcells_Mouse1.00557990
134NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00423101
135SA1_27219007_Chip-Seq_Bcells_Human0.99072155
136CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97979586
137* SPI1_23547873_ChIP-Seq_NB4_Human0.97613508
138CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97555447
139CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97275876
140* TP63_22573176_ChIP-Seq_HFKS_Human0.96940937
141CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96632249
142FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96201306
143GATA6_25053715_ChIP-Seq_YYC3_Human0.95737972
144SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94603630
145* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94354586
146MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92659499
147TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92475922
148CHD1_26751641_Chip-Seq_LNCaP_Human0.92443247
149E2F1_20622854_ChIP-Seq_HELA_Human0.92073016
150CTCF_21964334_Chip-Seq_Bcells_Human0.92005527
151TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91967575
152ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91519101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier4.00859401
2MP0001835_abnormal_antigen_presentation3.68506499
3MP0003724_increased_susceptibility_to3.68348037
4MP0010234_abnormal_vibrissa_follicle3.23672781
5MP0009278_abnormal_bone_marrow2.99777878
6MP0005000_abnormal_immune_tolerance2.84743792
7MP0002009_preneoplasia2.77932714
8MP0002419_abnormal_innate_immunity2.68255993
9MP0002452_abnormal_antigen_presenting2.61403590
10MP0000579_abnormal_nail_morphology2.61320508
11MP0005501_abnormal_skin_physiology2.58811290
12MP0002060_abnormal_skin_morphology2.56405154
13MP0003453_abnormal_keratinocyte_physiol2.54866671
14MP0003303_peritoneal_inflammation2.52895395
15MP0003763_abnormal_thymus_physiology2.52863045
16MP0009785_altered_susceptibility_to2.51230408
17MP0000685_abnormal_immune_system2.47741432
18MP0001873_stomach_inflammation2.24424031
19MP0002148_abnormal_hypersensitivity_rea2.19751837
20MP0006082_CNS_inflammation2.13012486
21MP0004264_abnormal_extraembryonic_tissu2.10675387
22MP0005174_abnormal_tail_pigmentation2.07145186
23MP0002098_abnormal_vibrissa_morphology2.06282833
24MP0008057_abnormal_DNA_replication2.00896710
25MP0002166_altered_tumor_susceptibility1.98373545
26MP0001545_abnormal_hematopoietic_system1.96202305
27MP0005397_hematopoietic_system_phenotyp1.96202305
28MP0004947_skin_inflammation1.92215639
29MP0001216_abnormal_epidermal_layer1.90599858
30MP0005075_abnormal_melanosome_morpholog1.88000184
31MP0002254_reproductive_system_inflammat1.87349435
32MP0002877_abnormal_melanocyte_morpholog1.81068372
33MP0000467_abnormal_esophagus_morphology1.80979512
34MP0001533_abnormal_skeleton_physiology1.80792189
35MP0000490_abnormal_crypts_of1.80132288
36MP0010352_gastrointestinal_tract_polyps1.78745833
37MP0002132_abnormal_respiratory_system1.73146894
38MP0003866_abnormal_defecation1.69694686
39MP0001666_abnormal_nutrient_absorption1.68299499
40MP0002429_abnormal_blood_cell1.67110417
41MP0003941_abnormal_skin_development1.65981561
42MP0010155_abnormal_intestine_physiology1.65182116
43MP0005275_abnormal_skin_tensile1.64374353
44MP0000470_abnormal_stomach_morphology1.63058851
45MP0001986_abnormal_taste_sensitivity1.62892429
46MP0005365_abnormal_bile_salt1.62748943
47MP0003283_abnormal_digestive_organ1.62040500
48MP0004381_abnormal_hair_follicle1.57342770
49MP0003183_abnormal_peptide_metabolism1.53770837
50MP0010030_abnormal_orbit_morphology1.50323391
51MP0002396_abnormal_hematopoietic_system1.49493688
52MP0010771_integument_phenotype1.46891144
53* MP0005220_abnormal_exocrine_pancreas1.40740611
54MP0005310_abnormal_salivary_gland1.39559572
55MP0002006_tumorigenesis1.37475273
56MP0002277_abnormal_respiratory_mucosa1.36668967
57MP0000377_abnormal_hair_follicle1.36416482
58MP0000367_abnormal_coat/_hair1.32450442
59MP0002405_respiratory_system_inflammati1.30849277
60MP0008469_abnormal_protein_level1.30385580
61MP0001851_eye_inflammation1.27776869
62MP0009931_abnormal_skin_appearance1.21790842
63MP0002933_joint_inflammation1.21053705
64MP0009333_abnormal_splenocyte_physiolog1.19228669
65MP0000383_abnormal_hair_follicle1.18163979
66MP0003436_decreased_susceptibility_to1.16496038
67MP0000678_abnormal_parathyroid_gland1.13106818
68MP0003300_gastrointestinal_ulcer1.12846805
69MP0008260_abnormal_autophagy1.12043862
70MP0005076_abnormal_cell_differentiation1.11462571
71MP0009764_decreased_sensitivity_to1.11163228
72MP0000762_abnormal_tongue_morphology1.10534720
73MP0010678_abnormal_skin_adnexa1.09546045
74MP0003878_abnormal_ear_physiology1.08645836
75MP0005377_hearing/vestibular/ear_phenot1.08645836
76MP0001663_abnormal_digestive_system1.07175840
77MP0000613_abnormal_salivary_gland1.05824117
78MP0005464_abnormal_platelet_physiology1.05274498
79MP0003705_abnormal_hypodermis_morpholog1.05078708
80MP0008995_early_reproductive_senescence1.04854340
81MP0005058_abnormal_lysosome_morphology1.02594695
82MP0003566_abnormal_cell_adhesion1.01335985
83MP0006072_abnormal_retinal_apoptosis1.01174380
84MP0002019_abnormal_tumor_incidence1.00076529
85MP0000477_abnormal_intestine_morphology0.98500186
86MP0002398_abnormal_bone_marrow0.97688160
87MP0005023_abnormal_wound_healing0.97104393
88MP0004233_abnormal_muscle_weight0.96699064
89MP0000703_abnormal_thymus_morphology0.96476251
90MP0000462_abnormal_digestive_system0.95212380
91MP0000858_altered_metastatic_potential0.94021788
92MP0002095_abnormal_skin_pigmentation0.92662584
93MP0003172_abnormal_lysosome_physiology0.92228354
94MP0003806_abnormal_nucleotide_metabolis0.92218562
95MP0005671_abnormal_response_to0.91976677
96MP0002249_abnormal_larynx_morphology0.91468016
97MP0000689_abnormal_spleen_morphology0.91337938
98MP0000371_diluted_coat_color0.90487102
99MP0002722_abnormal_immune_system0.90447164
100MP0002653_abnormal_ependyma_morphology0.90046011
101MP0001944_abnormal_pancreas_morphology0.89685234
102MP0001800_abnormal_humoral_immune0.88783904
103* MP0002693_abnormal_pancreas_physiology0.88780761
104MP0005085_abnormal_gallbladder_physiolo0.87577131
105MP0001340_abnormal_eyelid_morphology0.87542318
106MP0005025_abnormal_response_to0.86603988
107MP0003045_fibrosis0.86324284
108MP0001765_abnormal_ion_homeostasis0.85766297
109MP0000015_abnormal_ear_pigmentation0.85639638
110MP0003786_premature_aging0.84514451
111MP0000465_gastrointestinal_hemorrhage0.82580103
112MP0001845_abnormal_inflammatory_respons0.82373704
113MP0008961_abnormal_basal_metabolism0.82210097
114MP0002138_abnormal_hepatobiliary_system0.81886714
115MP0001191_abnormal_skin_condition0.79472843
116MP0003868_abnormal_feces_composition0.79350418
117MP0001790_abnormal_immune_system0.78871768
118MP0005387_immune_system_phenotype0.78871768
119MP0002420_abnormal_adaptive_immunity0.78847025
120MP0004808_abnormal_hematopoietic_stem0.77486739
121MP0004883_abnormal_blood_vessel0.76989254
122MP0001243_abnormal_dermal_layer0.76223634
123MP0003119_abnormal_digestive_system0.75913584
124MP0001819_abnormal_immune_cell0.75528792
125MP0002723_abnormal_immune_serum0.75261138
126MP0001849_ear_inflammation0.75226923
127MP0000716_abnormal_immune_system0.74583237
128MP0002928_abnormal_bile_duct0.73890758
129MP0003828_pulmonary_edema0.73720545
130MP0004185_abnormal_adipocyte_glucose0.73422740
131MP0003191_abnormal_cellular_cholesterol0.73366356
132MP0005367_renal/urinary_system_phenotyp0.73083527
133MP0000516_abnormal_urinary_system0.73083527
134MP0003638_abnormal_response/metabolism_0.72919998
135MP0000647_abnormal_sebaceous_gland0.72356546
136MP0005390_skeleton_phenotype0.71971130
137MP0005083_abnormal_biliary_tract0.71656006
138MP0002998_abnormal_bone_remodeling0.71336259
139MP0004043_abnormal_pH_regulation0.66027273
140MP0004130_abnormal_muscle_cell0.65575379
141MP0001853_heart_inflammation0.64641773
142MP0009763_increased_sensitivity_to0.63221905
143MP0009765_abnormal_xenobiotic_induced0.61153735
144MP0005381_digestive/alimentary_phenotyp0.61119869
145MP0008872_abnormal_physiological_respon0.60663121
146MP0008875_abnormal_xenobiotic_pharmacok0.56826065
147MP0005166_decreased_susceptibility_to0.55086925
148MP0003943_abnormal_hepatobiliary_system0.54623296
149MP0000249_abnormal_blood_vessel0.52816877
150MP0001664_abnormal_digestion0.51149471
151MP0004510_myositis0.50162707
152MP0003075_altered_response_to0.48644699
153MP0008874_decreased_physiological_sensi0.48305819
154MP0002136_abnormal_kidney_physiology0.47208369
155MP0005535_abnormal_body_temperature0.47133736

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.76624751
2Pustule (HP:0200039)5.27672607
3Hypotrichosis (HP:0001006)5.22479679
4Myositis (HP:0100614)5.16819216
5Recurrent bacterial skin infections (HP:0005406)4.58950807
6Stomatitis (HP:0010280)4.56107708
7Recurrent abscess formation (HP:0002722)4.51325141
8Plantar hyperkeratosis (HP:0007556)4.36679770
9Poikiloderma (HP:0001029)4.31291336
10Panhypogammaglobulinemia (HP:0003139)4.29387495
11Alopecia of scalp (HP:0002293)4.07416823
12Orchitis (HP:0100796)4.02393199
13Meningitis (HP:0001287)3.94263481
14Abnormal hemoglobin (HP:0011902)3.92775544
15Palmoplantar hyperkeratosis (HP:0000972)3.88812984
16Optic neuritis (HP:0100653)3.86046850
17Retrobulbar optic neuritis (HP:0100654)3.86046850
18Concave nail (HP:0001598)3.84511637
19Milia (HP:0001056)3.76009840
20Chronic mucocutaneous candidiasis (HP:0002728)3.74981452
21Recurrent cutaneous fungal infections (HP:0011370)3.74981452
22Agammaglobulinemia (HP:0004432)3.74513146
23Pili torti (HP:0003777)3.68213643
24Abnormality of macrophages (HP:0004311)3.65758919
25Palmar hyperkeratosis (HP:0010765)3.60505274
26Obstructive lung disease (HP:0006536)3.54910399
27Chronic obstructive pulmonary disease (HP:0006510)3.54910399
28Woolly hair (HP:0002224)3.50417895
29Recurrent skin infections (HP:0001581)3.49237176
30Encephalitis (HP:0002383)3.48013210
31Gastrointestinal infarctions (HP:0005244)3.40344420
32Increased IgE level (HP:0003212)3.39932634
33Mediastinal lymphadenopathy (HP:0100721)3.31913638
34Mucopolysacchariduria (HP:0008155)3.31407571
35Urinary glycosaminoglycan excretion (HP:0003541)3.31407571
36Amelogenesis imperfecta (HP:0000705)3.29897487
37Lip pit (HP:0100267)3.29304171
38Prolonged bleeding time (HP:0003010)3.25386514
39Abnormality of T cell physiology (HP:0011840)3.23830356
40Recurrent gram-negative bacterial infections (HP:0005420)3.22994133
41Nail dystrophy (HP:0008404)3.14624681
42Fragile nails (HP:0001808)3.13992612
43Vasculitis (HP:0002633)3.13329054
44Onycholysis (HP:0001806)3.07521816
45Dysostosis multiplex (HP:0000943)3.04879348
46Recurrent viral infections (HP:0004429)3.03461080
47Increased IgM level (HP:0003496)3.00750247
48Granulocytopenia (HP:0001913)2.96515945
49Abnormality of mucopolysaccharide metabolism (HP:0011020)2.94552975
50Abnormality of polysaccharide metabolism (HP:0011012)2.94552975
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.94552975
52Abnormality of T cell number (HP:0011839)2.94496732
53T lymphocytopenia (HP:0005403)2.94437071
54Erythema (HP:0010783)2.93498784
55Popliteal pterygium (HP:0009756)2.90768033
56Chest pain (HP:0100749)2.89869006
57Right ventricular cardiomyopathy (HP:0011663)2.86140942
58Premature skin wrinkling (HP:0100678)2.80842221
59Joint stiffness (HP:0001387)2.80797292
60Recurrent sinusitis (HP:0011108)2.79918374
61Turricephaly (HP:0000262)2.79741537
62Hemoptysis (HP:0002105)2.76912214
63Pulmonary infiltrates (HP:0002113)2.76906791
64Abnormality of cells of the erythroid lineage (HP:0012130)2.76325156
65Keratoconjunctivitis sicca (HP:0001097)2.76190586
66Abnormal hair laboratory examination (HP:0003328)2.74683836
67Rib fusion (HP:0000902)2.72437730
68Leukocytosis (HP:0001974)2.68049594
69Keratoconjunctivitis (HP:0001096)2.67748670
70Cellulitis (HP:0100658)2.67131476
71Growth hormone excess (HP:0000845)2.67121872
72Basal cell carcinoma (HP:0002671)2.66373308
73Dynein arm defect of respiratory motile cilia (HP:0012255)2.64977643
74Absent/shortened dynein arms (HP:0200106)2.64977643
75Hypochromic microcytic anemia (HP:0004840)2.63145953
76Squamous cell carcinoma (HP:0002860)2.60957803
77Urticaria (HP:0001025)2.58775494
78Large for gestational age (HP:0001520)2.55610604
79Severe combined immunodeficiency (HP:0004430)2.55141939
80Albinism (HP:0001022)2.54369750
81Papilloma (HP:0012740)2.52480407
82Verrucae (HP:0200043)2.52480407
83IgA deficiency (HP:0002720)2.51077018
84Nasal polyposis (HP:0100582)2.50272514
85Chronic sinusitis (HP:0011109)2.47874259
86Gastrointestinal inflammation (HP:0004386)2.46651601
87Abnormality of T cells (HP:0002843)2.45719268
88Vertebral hypoplasia (HP:0008417)2.45718288
89Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.45718288
90Ulnar bowing (HP:0003031)2.45702323
91Abnormal number of erythroid precursors (HP:0012131)2.45593650
92Abnormal blistering of the skin (HP:0008066)2.43340817
93Cheilitis (HP:0100825)2.43237473
94Inflammation of the large intestine (HP:0002037)2.43030802
95Autoimmune hemolytic anemia (HP:0001890)2.42392686
96Eosinophilia (HP:0001880)2.41753432
97Increased neuronal autofluorescent lipopigment (HP:0002074)2.41380618
98Gingivitis (HP:0000230)2.41268641
99Colitis (HP:0002583)2.41038291
100Fatigable weakness (HP:0003473)2.38341176
101Abnormality of the neuromuscular junction (HP:0003398)2.38341176
102Epistaxis (HP:0000421)2.37033384
103Stomach cancer (HP:0012126)2.36459886
104Facial hemangioma (HP:0000329)2.36252315
105Abnormal respiratory motile cilium morphology (HP:0005938)2.35725900
106Abnormal respiratory epithelium morphology (HP:0012253)2.35725900
107IgM deficiency (HP:0002850)2.35723733
108Lymphopenia (HP:0001888)2.34558814
109Short chin (HP:0000331)2.33789700
110Pancreatic islet-cell hyperplasia (HP:0004510)2.33365660
111Hypergammaglobulinemia (HP:0010702)2.32127244
112Abnormality of the nasal mucosa (HP:0000433)2.32127118
113Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.30406989
114Absent thumb (HP:0009777)2.29977067
115Annular pancreas (HP:0001734)2.29814289
116Abnormality of endocrine pancreas physiology (HP:0012093)2.28966277
117Abnormality of the pancreatic islet cells (HP:0006476)2.28966277
118Episodic fever (HP:0001954)2.27705635
119Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.26121894
120Abnormality of eosinophils (HP:0001879)2.25963085
121Bronchiectasis (HP:0002110)2.23645641
122Hypochromic anemia (HP:0001931)2.22774530
123Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22565460
124Spontaneous hematomas (HP:0007420)2.22000481
125Sepsis (HP:0100806)2.21274697
126Dysautonomia (HP:0002459)2.19780092
127Abnormality of cells of the lymphoid lineage (HP:0012140)2.18582815
128Increased cerebral lipofuscin (HP:0011813)2.18501880
129Abnormality of the pleura (HP:0002103)2.16571336
130Abnormality of B cell number (HP:0010975)2.14259552
131Arterial thrombosis (HP:0004420)2.14065566
132Abnormality of the gastric mucosa (HP:0004295)2.13861895
133Hyperparathyroidism (HP:0000843)2.13526183
134Seborrheic dermatitis (HP:0001051)2.13474893
135Pulmonary embolism (HP:0002204)2.10829831
136Bronchitis (HP:0012387)2.10558679
137Gangrene (HP:0100758)2.10549665
138Elevated erythrocyte sedimentation rate (HP:0003565)2.10149553
139Orthostatic hypotension (HP:0001278)2.10067991
140Bowed forearm bones (HP:0003956)2.09689987
141Bowing of the arm (HP:0006488)2.09689987
142Skin ulcer (HP:0200042)2.08976608
143Anorexia (HP:0002039)2.08222540
144Autoimmune thrombocytopenia (HP:0001973)2.07432813
145Exocrine pancreatic insufficiency (HP:0001738)2.06246205
146Abnormal ciliary motility (HP:0012262)2.04681340
147Tongue fasciculations (HP:0001308)2.04387683
148Abnormal delayed hypersensitivity skin test (HP:0002963)2.03067808
149Recurrent otitis media (HP:0000403)2.02375471
150Thrombocytosis (HP:0001894)2.02205648
151Osteomyelitis (HP:0002754)2.01977361
152Skin rash (HP:0000988)2.00127712
153Alacrima (HP:0000522)1.99210806
154Petechiae (HP:0000967)1.98971142
155Sparse scalp hair (HP:0002209)1.98205354
156Corneal erosion (HP:0200020)1.97996813
157IgG deficiency (HP:0004315)1.97511673
158Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.97110212
159Congenital hip dislocation (HP:0001374)1.96742293
160Muscle fiber atrophy (HP:0100295)1.96710220
161Abnormality of the prostate (HP:0008775)1.95425428
162Recurrent fungal infections (HP:0002841)1.95182344
163Abnormal respiratory motile cilium physiology (HP:0012261)1.92655956
164Recurrent bronchitis (HP:0002837)1.91660428
165Papilledema (HP:0001085)1.91398380
166Microcytic anemia (HP:0001935)1.91012931
167Reticulocytopenia (HP:0001896)1.89361467
168Selective tooth agenesis (HP:0001592)1.89328519
169Type I diabetes mellitus (HP:0100651)1.89057774
170Gastrointestinal dysmotility (HP:0002579)1.87662270
171Erythroderma (HP:0001019)1.87236396
172Sparse eyelashes (HP:0000653)1.86864814
173Chronic otitis media (HP:0000389)1.86748300
174Progressive neurologic deterioration (HP:0002344)1.86661724
175Congenital ichthyosiform erythroderma (HP:0007431)1.84060456
176Abnormality of the distal phalanges of the toes (HP:0010182)1.83294058
177Vaginal fistula (HP:0004320)1.82927520
178Hypercortisolism (HP:0001578)1.82503236
179Intestinal atresia (HP:0011100)1.81025905
180Anteriorly placed anus (HP:0001545)1.76975463
181Ectropion (HP:0000656)1.76363719

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.79152571
2ICK3.70182504
3RIPK43.42203346
4MAP3K63.41860567
5MAP3K113.05162968
6PIM22.71224494
7FLT32.66847110
8MAPKAPK32.65865873
9ERN12.63250000
10DDR22.53572667
11IRAK42.35522204
12EEF2K2.33635668
13FES2.31913669
14MAP4K12.23550372
15DYRK1B2.14362366
16MATK2.11918391
17RPS6KB21.91780271
18BCKDK1.91133920
19CSK1.86156386
20TRIB31.82645446
21TRPM71.78130798
22PRKD21.74895434
23HIPK21.63695676
24PRPF4B1.60903199
25MAP3K31.58516694
26HCK1.55067496
27ZAP701.55028648
28MAP3K131.51487115
29PINK11.49776528
30SMG11.47957645
31FGR1.47942230
32DAPK11.44791695
33TYRO31.42080674
34MAP3K141.38568297
35MAP3K101.37479144
36CSF1R1.34987214
37SIK21.33087583
38PDGFRA1.31466531
39MST41.30502935
40MAPK111.24557597
41PASK1.21890208
42BTK1.20861481
43YES11.19088110
44PIM11.16105047
45LRRK21.12739172
46SIK31.08906879
47CDK71.08517991
48CDK61.07539174
49NME21.04961132
50JAK11.03793949
51BMX1.03313163
52MARK31.03274113
53DYRK31.02918361
54MAP2K31.02093372
55UHMK11.01180684
56PIK3CG1.00640932
57TYK20.98831602
58SIK10.98583325
59PKN20.96866845
60PRKCQ0.96277657
61RPS6KL10.95546063
62RPS6KC10.95546063
63TESK20.92711121
64JAK30.86698143
65RPS6KA60.85866554
66EPHA20.83448015
67TEC0.82746462
68CAMKK10.81281560
69MAP2K20.79540985
70KDR0.79200672
71PTK60.78871156
72PDK10.78770788
73STK100.78537360
74FRK0.77431041
75RIPK10.76913579
76NLK0.74757758
77STK110.74466642
78FGFR40.74159516
79TLK10.74083136
80KIT0.73959306
81BLK0.72760527
82IRAK10.71850219
83ITK0.71807298
84TNK20.70897487
85LCK0.70483842
86TBK10.69591910
87MST1R0.69332426
88MAPK120.65924953
89GSK3A0.65376524
90TXK0.64150916
91INSRR0.62612291
92PTK2B0.60796722
93CDC42BPA0.60567949
94TAOK10.59888722
95CDK190.58883665
96PTK20.58610869
97MAP2K60.56894384
98MAP3K20.56464437
99PRKCI0.54233816
100LYN0.54162520
101MAP3K70.54071780
102TAOK30.52716099
103MAPKAPK20.52669881
104PDPK10.52214445
105PRKG20.51622112
106DAPK20.48830869
107PRKCH0.48101100
108MAP3K10.47229598
109RPS6KA10.47133503
110MELK0.45658278
111IRAK30.45582272
112BMPR20.45497459
113FYN0.45207711
114SYK0.45160771
115GRK60.44947396
116EPHB10.44829350
117MAPK70.43975759
118MTOR0.43640391
119MAPK30.43106800
120TGFBR20.43006758
121IKBKB0.42760297
122IKBKE0.41441063
123STK380.41354663
124TGFBR10.41246770
125JAK20.40867055
126PRKAA20.40132052
127FGFR30.38968179
128PDGFRB0.38693561
129RAF10.38321162
130MARK20.38259475
131ADRBK20.37887729
132CAMKK20.36882402
133PRKAA10.36541574
134MAPK40.35562572
135NUAK10.32782961
136SCYL20.32070528
137RET0.31639040
138CHUK0.31427555
139MAP2K40.31305573
140CDK40.27507611

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.32161605
2Fatty acid biosynthesis_Homo sapiens_hsa000613.49384187
3Graft-versus-host disease_Homo sapiens_hsa053323.20612314
4Ribosome_Homo sapiens_hsa030103.17595022
5Allograft rejection_Homo sapiens_hsa053303.14229232
6Primary immunodeficiency_Homo sapiens_hsa053403.12559588
7Base excision repair_Homo sapiens_hsa034103.03681824
8Autoimmune thyroid disease_Homo sapiens_hsa053202.98424128
9Mismatch repair_Homo sapiens_hsa034302.81220619
10Type I diabetes mellitus_Homo sapiens_hsa049402.38985479
11DNA replication_Homo sapiens_hsa030302.31026622
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.23638915
13Osteoclast differentiation_Homo sapiens_hsa043802.20105195
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.18605172
15Staphylococcus aureus infection_Homo sapiens_hsa051502.16243777
16Folate biosynthesis_Homo sapiens_hsa007902.14794741
17Sulfur relay system_Homo sapiens_hsa041222.13199786
18Asthma_Homo sapiens_hsa053102.11958920
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10581432
20Protein export_Homo sapiens_hsa030602.09777874
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.90650616
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.78440487
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74945380
24Notch signaling pathway_Homo sapiens_hsa043301.74405567
25Tuberculosis_Homo sapiens_hsa051521.62001236
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.60143932
27Acute myeloid leukemia_Homo sapiens_hsa052211.58840662
28Viral myocarditis_Homo sapiens_hsa054161.57189251
29p53 signaling pathway_Homo sapiens_hsa041151.55638415
30Circadian rhythm_Homo sapiens_hsa047101.52149003
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.48031615
32Bladder cancer_Homo sapiens_hsa052191.44531593
33N-Glycan biosynthesis_Homo sapiens_hsa005101.44336327
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39220242
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37122882
36Fat digestion and absorption_Homo sapiens_hsa049751.36709110
37Chemokine signaling pathway_Homo sapiens_hsa040621.33698970
38Pancreatic secretion_Homo sapiens_hsa049721.32291282
39Thyroid cancer_Homo sapiens_hsa052161.31579216
40VEGF signaling pathway_Homo sapiens_hsa043701.20085110
41Malaria_Homo sapiens_hsa051441.18771929
42mTOR signaling pathway_Homo sapiens_hsa041501.12471873
43TNF signaling pathway_Homo sapiens_hsa046681.10463528
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08724830
45Legionellosis_Homo sapiens_hsa051341.08621653
46Adherens junction_Homo sapiens_hsa045201.05795641
47Nucleotide excision repair_Homo sapiens_hsa034201.03889289
48Shigellosis_Homo sapiens_hsa051311.01913207
49Measles_Homo sapiens_hsa051620.99196117
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.98748522
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96485959
52African trypanosomiasis_Homo sapiens_hsa051430.96239633
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93988273
54Arginine and proline metabolism_Homo sapiens_hsa003300.92803827
55Sulfur metabolism_Homo sapiens_hsa009200.91347454
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.91109797
57Rheumatoid arthritis_Homo sapiens_hsa053230.89980833
58ABC transporters_Homo sapiens_hsa020100.89327757
59Hedgehog signaling pathway_Homo sapiens_hsa043400.87768917
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.87736678
61Antigen processing and presentation_Homo sapiens_hsa046120.86889242
62Homologous recombination_Homo sapiens_hsa034400.86804539
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86633184
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86491838
65B cell receptor signaling pathway_Homo sapiens_hsa046620.86320626
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84956941
67Histidine metabolism_Homo sapiens_hsa003400.83559689
68Caffeine metabolism_Homo sapiens_hsa002320.83550417
69Herpes simplex infection_Homo sapiens_hsa051680.83163303
70Linoleic acid metabolism_Homo sapiens_hsa005910.82613972
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81339973
72Non-small cell lung cancer_Homo sapiens_hsa052230.81154076
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81123829
74Chronic myeloid leukemia_Homo sapiens_hsa052200.79599469
75Galactose metabolism_Homo sapiens_hsa000520.78638997
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77441498
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75603776
78Hippo signaling pathway_Homo sapiens_hsa043900.75106720
79Other glycan degradation_Homo sapiens_hsa005110.74628203
80T cell receptor signaling pathway_Homo sapiens_hsa046600.72442913
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72121720
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.71119883
83Regulation of autophagy_Homo sapiens_hsa041400.70782695
84Selenocompound metabolism_Homo sapiens_hsa004500.70562173
85Biosynthesis of amino acids_Homo sapiens_hsa012300.69327975
86Basal cell carcinoma_Homo sapiens_hsa052170.68385474
87Epstein-Barr virus infection_Homo sapiens_hsa051690.68164419
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68102983
89Fatty acid metabolism_Homo sapiens_hsa012120.67845001
90Choline metabolism in cancer_Homo sapiens_hsa052310.67546112
91Prolactin signaling pathway_Homo sapiens_hsa049170.67300863
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66270167
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66136062
94Spliceosome_Homo sapiens_hsa030400.64710836
95Hematopoietic cell lineage_Homo sapiens_hsa046400.64322759
96Protein digestion and absorption_Homo sapiens_hsa049740.64290596
97Small cell lung cancer_Homo sapiens_hsa052220.63122257
98Fructose and mannose metabolism_Homo sapiens_hsa000510.61363450
99Pertussis_Homo sapiens_hsa051330.60834001
100Phagosome_Homo sapiens_hsa041450.58921547
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57832580
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.54714643
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.54542486
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54449291
105Arachidonic acid metabolism_Homo sapiens_hsa005900.53358945
106Viral carcinogenesis_Homo sapiens_hsa052030.51589238
107Inositol phosphate metabolism_Homo sapiens_hsa005620.51219278
108Ether lipid metabolism_Homo sapiens_hsa005650.49942550
109Hepatitis B_Homo sapiens_hsa051610.47482480
110Wnt signaling pathway_Homo sapiens_hsa043100.46240755
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45998019
112Endocytosis_Homo sapiens_hsa041440.45967558
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45827750
114Insulin resistance_Homo sapiens_hsa049310.45028837
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44053268
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.43981203
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.42057929
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41590595
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41318334
120Hepatitis C_Homo sapiens_hsa051600.40975001
121MAPK signaling pathway_Homo sapiens_hsa040100.40800737
122Leishmaniasis_Homo sapiens_hsa051400.40597542
123Insulin signaling pathway_Homo sapiens_hsa049100.40458288
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.40200733
125Lysosome_Homo sapiens_hsa041420.40074143
126Glutathione metabolism_Homo sapiens_hsa004800.39511623
127Toxoplasmosis_Homo sapiens_hsa051450.38814497
128Glycerolipid metabolism_Homo sapiens_hsa005610.38599668
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37855851
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37824515
131Colorectal cancer_Homo sapiens_hsa052100.37798687
132Lysine degradation_Homo sapiens_hsa003100.37729097
133HTLV-I infection_Homo sapiens_hsa051660.36961162
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36775605
135TGF-beta signaling pathway_Homo sapiens_hsa043500.35865912
136GnRH signaling pathway_Homo sapiens_hsa049120.35294613
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.35277845
138FoxO signaling pathway_Homo sapiens_hsa040680.34706389
139Apoptosis_Homo sapiens_hsa042100.34639687
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33818176
141Platelet activation_Homo sapiens_hsa046110.33586020
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33279637
143RNA transport_Homo sapiens_hsa030130.31763587
144Pancreatic cancer_Homo sapiens_hsa052120.30968399
145Influenza A_Homo sapiens_hsa051640.29770942
146mRNA surveillance pathway_Homo sapiens_hsa030150.29060418
147Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28781663
148Vascular smooth muscle contraction_Homo sapiens_hsa042700.28547449
149Dorso-ventral axis formation_Homo sapiens_hsa043200.27756733
150Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26984611
151Salmonella infection_Homo sapiens_hsa051320.26019679
152Type II diabetes mellitus_Homo sapiens_hsa049300.25547766

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