SYT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.55939440
2synaptic vesicle exocytosis (GO:0016079)5.33530129
3neuron cell-cell adhesion (GO:0007158)5.24002982
4vocalization behavior (GO:0071625)5.13031604
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.90513572
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.85131616
7regulation of synaptic vesicle exocytosis (GO:2000300)4.75970792
8protein localization to synapse (GO:0035418)4.73078597
9synaptic vesicle maturation (GO:0016188)4.57384598
10glutamate secretion (GO:0014047)4.51937282
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.50341068
12regulation of glutamate receptor signaling pathway (GO:1900449)4.40249987
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.21366743
14regulation of synaptic vesicle transport (GO:1902803)4.09098902
15* neurotransmitter secretion (GO:0007269)4.06683894
16locomotory exploration behavior (GO:0035641)4.05362616
17presynaptic membrane assembly (GO:0097105)4.04341051
18ionotropic glutamate receptor signaling pathway (GO:0035235)3.95910060
19postsynaptic membrane organization (GO:0001941)3.93776613
20synaptic vesicle docking involved in exocytosis (GO:0016081)3.92540556
21proline transport (GO:0015824)3.90377478
22layer formation in cerebral cortex (GO:0021819)3.87914965
23neuron recognition (GO:0008038)3.86514945
24glutamate receptor signaling pathway (GO:0007215)3.86463739
25exploration behavior (GO:0035640)3.84407812
26neurotransmitter-gated ion channel clustering (GO:0072578)3.81503410
27regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.77561810
28neuronal action potential propagation (GO:0019227)3.77494945
29neuron-neuron synaptic transmission (GO:0007270)3.75531120
30positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.70533230
31establishment of mitochondrion localization (GO:0051654)3.68223193
32synaptic transmission, glutamatergic (GO:0035249)3.67867947
33cell migration in hindbrain (GO:0021535)3.67036056
34presynaptic membrane organization (GO:0097090)3.65804334
35central nervous system projection neuron axonogenesis (GO:0021952)3.64125457
36neurofilament cytoskeleton organization (GO:0060052)3.60370273
37gamma-aminobutyric acid signaling pathway (GO:0007214)3.59809493
38regulation of synapse structural plasticity (GO:0051823)3.57306723
39negative regulation of microtubule polymerization (GO:0031115)3.56899095
40synapse assembly (GO:0007416)3.53566071
41positive regulation of synapse maturation (GO:0090129)3.47459098
42* neurotransmitter transport (GO:0006836)3.47394607
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.45235118
44mechanosensory behavior (GO:0007638)3.43258809
45axonal fasciculation (GO:0007413)3.43141758
46dendritic spine morphogenesis (GO:0060997)3.42076595
47regulation of postsynaptic membrane potential (GO:0060078)3.41890330
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40454250
49positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.40237863
50regulation of neuronal synaptic plasticity (GO:0048168)3.39527291
51positive regulation of synaptic transmission, GABAergic (GO:0032230)3.37353744
52regulation of neurotransmitter secretion (GO:0046928)3.36572146
53detection of calcium ion (GO:0005513)3.35647032
54regulation of long-term neuronal synaptic plasticity (GO:0048169)3.32653227
55mating behavior (GO:0007617)3.31784141
56regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.31282897
57synaptic vesicle endocytosis (GO:0048488)3.29259762
58behavioral response to nicotine (GO:0035095)3.29220295
59response to auditory stimulus (GO:0010996)3.28667598
60pyrimidine nucleobase catabolic process (GO:0006208)3.25000458
61behavioral response to ethanol (GO:0048149)3.24491286
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.23886954
63activation of protein kinase A activity (GO:0034199)3.23825244
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.22976543
65cerebellar Purkinje cell differentiation (GO:0021702)3.22916421
66innervation (GO:0060384)3.21991375
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.20641142
68positive regulation of synapse assembly (GO:0051965)3.19512071
69dendrite morphogenesis (GO:0048813)3.18041635
70transmission of nerve impulse (GO:0019226)3.17112358
71response to histamine (GO:0034776)3.14779850
72negative regulation of dendrite morphogenesis (GO:0050774)3.14179355
73mitochondrion transport along microtubule (GO:0047497)3.14120484
74establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.14120484
75cerebellar granule cell differentiation (GO:0021707)3.13627103
76positive regulation of membrane potential (GO:0045838)3.12553448
77membrane depolarization during action potential (GO:0086010)3.12235773
78regulation of neurotransmitter transport (GO:0051588)3.11789542
79negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.11434233
80startle response (GO:0001964)3.11053906
81* regulation of neurotransmitter levels (GO:0001505)3.09267806
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.06362331
83establishment of synaptic vesicle localization (GO:0097480)3.06071865
84synaptic vesicle transport (GO:0048489)3.06071865
85long-term memory (GO:0007616)3.03904325
86prepulse inhibition (GO:0060134)3.03119497
87fear response (GO:0042596)3.02970222
88membrane depolarization (GO:0051899)3.02920505
89gamma-aminobutyric acid transport (GO:0015812)3.02016695
90neuronal ion channel clustering (GO:0045161)3.00519876
91long-term synaptic potentiation (GO:0060291)2.98499336
92central nervous system neuron axonogenesis (GO:0021955)2.97497240
93auditory behavior (GO:0031223)2.97001692
94positive regulation of dendritic spine morphogenesis (GO:0061003)2.96383395
95retinal ganglion cell axon guidance (GO:0031290)2.96096155
96membrane hyperpolarization (GO:0060081)2.95763370
97regulation of cAMP-dependent protein kinase activity (GO:2000479)2.93976196
98synaptic transmission (GO:0007268)2.93555494
99synapse organization (GO:0050808)2.91237298
100cellular potassium ion homeostasis (GO:0030007)2.91205374
101striatum development (GO:0021756)2.90363098
102response to pheromone (GO:0019236)2.90314601
103organelle transport along microtubule (GO:0072384)2.89980715
104positive regulation of neurotransmitter transport (GO:0051590)2.89801835
105regulation of respiratory system process (GO:0044065)2.87056911
106regulation of dendritic spine morphogenesis (GO:0061001)2.86803739
107neuromuscular synaptic transmission (GO:0007274)2.86709329
108behavioral fear response (GO:0001662)2.86173748
109behavioral defense response (GO:0002209)2.86173748
110cerebral cortex radially oriented cell migration (GO:0021799)2.86162371
111establishment of vesicle localization (GO:0051650)2.84151318
112nucleobase catabolic process (GO:0046113)2.84004018
113neuronal action potential (GO:0019228)2.83581515
114regulation of synaptic plasticity (GO:0048167)2.83058720
115behavioral response to cocaine (GO:0048148)2.82713985
116positive regulation of potassium ion transmembrane transport (GO:1901381)2.82312977
117vesicle transport along microtubule (GO:0047496)2.81313966
118regulation of synapse maturation (GO:0090128)2.81123815
119adult walking behavior (GO:0007628)2.80868681
120positive regulation of dendritic spine development (GO:0060999)2.79934639
121regulation of synapse assembly (GO:0051963)2.79581378
122dendritic spine organization (GO:0097061)2.74787849
123glycosphingolipid biosynthetic process (GO:0006688)2.74713744
124adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.73758274
125adult behavior (GO:0030534)2.71377459
126negative regulation of axon extension (GO:0030517)2.71136539
127negative regulation of dendrite development (GO:2000171)2.69216741
128negative regulation of cytosolic calcium ion concentration (GO:0051481)2.66453135
129cerebellum development (GO:0021549)2.66214755

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.67901506
2GBX2_23144817_ChIP-Seq_PC3_Human4.01109899
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07119126
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91245283
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90751654
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.79597511
7TAF15_26573619_Chip-Seq_HEK293_Human2.55220511
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.54782825
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50034899
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.49271348
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48535187
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45173448
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45173448
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42945581
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40666698
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37615906
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.33145733
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32375708
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31661222
20* REST_18959480_ChIP-ChIP_MESCs_Mouse2.22963953
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.19347044
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13935287
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.11194546
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11144407
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.00854757
26* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00481181
27* RARB_27405468_Chip-Seq_BRAIN_Mouse2.00146022
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.99077993
29AR_21572438_ChIP-Seq_LNCaP_Human1.97299458
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90288999
31DROSHA_22980978_ChIP-Seq_HELA_Human1.89666928
32SMAD4_21799915_ChIP-Seq_A2780_Human1.88219489
33* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87551837
34IGF1R_20145208_ChIP-Seq_DFB_Human1.77581173
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75124391
36* P300_19829295_ChIP-Seq_ESCs_Human1.74254471
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71063221
38ZNF274_21170338_ChIP-Seq_K562_Hela1.66336879
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64570945
40* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64100307
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.62539776
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58401764
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.54194700
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51891412
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50100989
46RNF2_27304074_Chip-Seq_NSC_Mouse1.48059099
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46217681
48* PIAS1_25552417_ChIP-Seq_VCAP_Human1.44572627
49FUS_26573619_Chip-Seq_HEK293_Human1.44482158
50* SMAD3_21741376_ChIP-Seq_EPCs_Human1.42944462
51* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42264393
52AR_25329375_ChIP-Seq_VCAP_Human1.41579997
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39760309
54* SOX2_21211035_ChIP-Seq_LN229_Gbm1.39487991
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39042797
56* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37201958
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32644957
58VDR_22108803_ChIP-Seq_LS180_Human1.32145041
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31603263
60STAT3_23295773_ChIP-Seq_U87_Human1.30475882
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.30386421
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.28242681
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27098689
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25136561
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20739368
66* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20202236
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19455221
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.19412671
69* TCF4_23295773_ChIP-Seq_U87_Human1.15854339
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14694650
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.14634707
72ER_23166858_ChIP-Seq_MCF-7_Human1.14445171
73* RUNX2_22187159_ChIP-Seq_PCA_Human1.13677782
74AR_19668381_ChIP-Seq_PC3_Human1.12240120
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11983181
76EWS_26573619_Chip-Seq_HEK293_Human1.10608237
77* JUN_21703547_ChIP-Seq_K562_Human1.09957361
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09624759
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09485574
80CBP_20019798_ChIP-Seq_JUKART_Human1.09485574
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09450462
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08279351
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.06696936
84* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06239855
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03492316
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02951370
87LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02814287
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02648299
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02007918
90AHR_22903824_ChIP-Seq_MCF-7_Human1.01654239
91* PRDM14_20953172_ChIP-Seq_ESCs_Human1.01537798
92STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01344464
93BCAT_22108803_ChIP-Seq_LS180_Human0.99968186
94* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99915520
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99564647
96SOX9_26525672_Chip-Seq_HEART_Mouse0.99136913
97RING1B_27294783_Chip-Seq_NPCs_Mouse0.98466533
98ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97963364
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97862962
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97862962
101NANOG_18555785_Chip-Seq_ESCs_Mouse0.97536751
102* SMAD3_21741376_ChIP-Seq_ESCs_Human0.95710855
103FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93422795
104* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93350544
105KDM2B_26808549_Chip-Seq_REH_Human0.93301656
106* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93124811
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92967853
108TAL1_26923725_Chip-Seq_HPCs_Mouse0.91465280
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90988136
110* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90579842
111RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90182189
112WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89990556
113FLI1_21867929_ChIP-Seq_TH2_Mouse0.89788267
114TP53_18474530_ChIP-ChIP_U2OS_Human0.88607523
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.88196830

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.59298461
2MP0003880_abnormal_central_pattern4.31306181
3MP0004270_analgesia3.66773462
4MP0003635_abnormal_synaptic_transmissio3.62978265
5MP0001968_abnormal_touch/_nociception3.31868579
6MP0009745_abnormal_behavioral_response3.05926175
7MP0002734_abnormal_mechanical_nocicepti2.95381385
8MP0006276_abnormal_autonomic_nervous2.92889081
9* MP0002063_abnormal_learning/memory/cond2.92641048
10MP0002822_catalepsy2.90533061
11MP0002735_abnormal_chemical_nociception2.86995618
12MP0009046_muscle_twitch2.84381584
13MP0002064_seizures2.78607661
14MP0005423_abnormal_somatic_nervous2.75616851
15MP0002572_abnormal_emotion/affect_behav2.65508362
16MP0002736_abnormal_nociception_after2.54475215
17MP0002272_abnormal_nervous_system2.41979874
18MP0002733_abnormal_thermal_nociception2.37839965
19MP0001440_abnormal_grooming_behavior2.29097426
20MP0001970_abnormal_pain_threshold2.20560405
21MP0002184_abnormal_innervation2.12027549
22MP0001486_abnormal_startle_reflex2.09530639
23MP0002067_abnormal_sensory_capabilities2.08684089
24MP0001501_abnormal_sleep_pattern1.99217871
25MP0004924_abnormal_behavior1.99137998
26MP0005386_behavior/neurological_phenoty1.99137998
27MP0001529_abnormal_vocalization1.98109204
28MP0000778_abnormal_nervous_system1.92407359
29MP0001984_abnormal_olfaction1.91767722
30MP0003122_maternal_imprinting1.84387512
31MP0002557_abnormal_social/conspecific_i1.81258573
32MP0010386_abnormal_urinary_bladder1.78826733
33MP0003283_abnormal_digestive_organ1.78741194
34MP0009780_abnormal_chondrocyte_physiolo1.76596664
35MP0001188_hyperpigmentation1.73472759
36MP0004858_abnormal_nervous_system1.68591041
37MP0003123_paternal_imprinting1.68476715
38MP0001905_abnormal_dopamine_level1.65562878
39MP0002909_abnormal_adrenal_gland1.63865990
40MP0004811_abnormal_neuron_physiology1.59958639
41MP0005646_abnormal_pituitary_gland1.56348061
42MP0002638_abnormal_pupillary_reflex1.54605150
43MP0008877_abnormal_DNA_methylation1.54531622
44MP0008569_lethality_at_weaning1.54056779
45MP0000372_irregular_coat_pigmentation1.53691854
46MP0000955_abnormal_spinal_cord1.53024055
47MP0005645_abnormal_hypothalamus_physiol1.51332437
48MP0003329_amyloid_beta_deposits1.51208385
49MP0001502_abnormal_circadian_rhythm1.43033953
50MP0004142_abnormal_muscle_tone1.40452209
51MP0002882_abnormal_neuron_morphology1.40435524
52MP0003787_abnormal_imprinting1.37240412
53* MP0002066_abnormal_motor_capabilities/c1.32289771
54MP0003879_abnormal_hair_cell1.30698677
55MP0005551_abnormal_eye_electrophysiolog1.28735676
56MP0005171_absent_coat_pigmentation1.27548181
57MP0002837_dystrophic_cardiac_calcinosis1.26267853
58MP0002876_abnormal_thyroid_physiology1.15727648
59MP0002234_abnormal_pharynx_morphology1.14493220
60MP0002751_abnormal_autonomic_nervous1.11629196
61MP0006072_abnormal_retinal_apoptosis1.10954454
62MP0000566_synostosis1.08469639
63MP0003890_abnormal_embryonic-extraembry1.06437315
64MP0003633_abnormal_nervous_system1.05761153
65MP0008872_abnormal_physiological_respon1.05014613
66MP0002152_abnormal_brain_morphology1.03916619
67MP0000631_abnormal_neuroendocrine_gland1.03145645
68MP0004885_abnormal_endolymph1.03057609
69MP0000751_myopathy1.01126295
70MP0000569_abnormal_digit_pigmentation0.99774412
71MP0005394_taste/olfaction_phenotype0.99307858
72MP0005499_abnormal_olfactory_system0.99307858
73MP0002229_neurodegeneration0.98788273
74MP0001986_abnormal_taste_sensitivity0.98022274
75MP0004742_abnormal_vestibular_system0.95780624
76MP0004145_abnormal_muscle_electrophysio0.94798242
77MP0003631_nervous_system_phenotype0.92748657
78MP0002752_abnormal_somatic_nervous0.91336694
79MP0002069_abnormal_eating/drinking_beha0.91062478
80MP0005409_darkened_coat_color0.90164989
81MP0005535_abnormal_body_temperature0.88897854
82MP0002090_abnormal_vision0.88724746
83MP0003011_delayed_dark_adaptation0.87520969
84MP0004133_heterotaxia0.83674425
85MP0003938_abnormal_ear_development0.83407923
86MP0003119_abnormal_digestive_system0.81097150
87MP0001963_abnormal_hearing_physiology0.80921888
88MP0004085_abnormal_heartbeat0.80273586
89MP0000013_abnormal_adipose_tissue0.78482043
90MP0000015_abnormal_ear_pigmentation0.76832327
91MP0001485_abnormal_pinna_reflex0.76003237
92MP0005253_abnormal_eye_physiology0.75774820
93MP0003634_abnormal_glial_cell0.74343409
94MP0001944_abnormal_pancreas_morphology0.73252281
95MP0002102_abnormal_ear_morphology0.71039684
96MP0002082_postnatal_lethality0.70366322
97MP0010770_preweaning_lethality0.70366322
98MP0000538_abnormal_urinary_bladder0.69874893
99MP0003121_genomic_imprinting0.67911961
100MP0010769_abnormal_survival0.66085158
101MP0009379_abnormal_foot_pigmentation0.65790614
102MP0003137_abnormal_impulse_conducting0.65458581
103MP0005379_endocrine/exocrine_gland_phen0.65428659
104MP0008874_decreased_physiological_sensi0.63765465
105MP0005187_abnormal_penis_morphology0.63405472
106MP0008789_abnormal_olfactory_epithelium0.63395740
107MP0006292_abnormal_olfactory_placode0.63389135
108MP0010768_mortality/aging0.63281404
109MP0003632_abnormal_nervous_system0.63179943
110MP0001664_abnormal_digestion0.62423075
111MP0001299_abnormal_eye_distance/0.61090421
112MP0002928_abnormal_bile_duct0.60919964
113MP0004215_abnormal_myocardial_fiber0.60799034
114MP0001943_abnormal_respiration0.59423470
115MP0005195_abnormal_posterior_eye0.57662480
116MP0004233_abnormal_muscle_weight0.56330255
117MP0004043_abnormal_pH_regulation0.55588938
118MP0003861_abnormal_nervous_system0.54907616
119MP0000026_abnormal_inner_ear0.54447683
120MP0001177_atelectasis0.54283359

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.27363506
2Myokymia (HP:0002411)5.58059896
3Focal seizures (HP:0007359)5.08213433
4Atonic seizures (HP:0010819)4.83979838
5Visual hallucinations (HP:0002367)4.80786064
6Epileptic encephalopathy (HP:0200134)4.74880071
7Febrile seizures (HP:0002373)4.37630141
8Progressive cerebellar ataxia (HP:0002073)4.28774851
9Absence seizures (HP:0002121)4.26566476
10Dialeptic seizures (HP:0011146)3.83138866
11Limb dystonia (HP:0002451)3.79876236
12Generalized tonic-clonic seizures (HP:0002069)3.59671130
13Hypothermia (HP:0002045)3.56830406
14Action tremor (HP:0002345)3.45087710
15Hyperventilation (HP:0002883)3.39560992
16Broad-based gait (HP:0002136)3.39549095
17Pheochromocytoma (HP:0002666)3.28798384
18Amblyopia (HP:0000646)3.27896326
19Polyphagia (HP:0002591)3.21682621
20Abnormal eating behavior (HP:0100738)2.98954631
21Drooling (HP:0002307)2.96182816
22Excessive salivation (HP:0003781)2.96182816
23Ankle clonus (HP:0011448)2.92807898
24Neuroendocrine neoplasm (HP:0100634)2.92516157
25Supranuclear gaze palsy (HP:0000605)2.91604712
26Blue irides (HP:0000635)2.89059688
27Mutism (HP:0002300)2.88954523
28Truncal ataxia (HP:0002078)2.86773028
29Failure to thrive in infancy (HP:0001531)2.82628330
30Progressive inability to walk (HP:0002505)2.81640718
31Poor eye contact (HP:0000817)2.81099257
32Abnormality of the corticospinal tract (HP:0002492)2.79098922
33Gait imbalance (HP:0002141)2.78483184
34Anxiety (HP:0000739)2.74506592
35Epileptiform EEG discharges (HP:0011182)2.72439337
36Agitation (HP:0000713)2.71764001
37Impaired vibration sensation in the lower limbs (HP:0002166)2.69703444
38Depression (HP:0000716)2.68961272
39EEG with generalized epileptiform discharges (HP:0011198)2.63062497
40Gaze-evoked nystagmus (HP:0000640)2.62462060
41Insidious onset (HP:0003587)2.58562516
42Termporal pattern (HP:0011008)2.58562516
43Dysdiadochokinesis (HP:0002075)2.54407188
44Urinary bladder sphincter dysfunction (HP:0002839)2.54399543
45Abnormal social behavior (HP:0012433)2.54043869
46Impaired social interactions (HP:0000735)2.54043869
47Hypoventilation (HP:0002791)2.52341892
48Abnormal hair whorl (HP:0010721)2.50927040
49Papilledema (HP:0001085)2.45632223
50Abnormality of the lower motor neuron (HP:0002366)2.42237356
51Hypsarrhythmia (HP:0002521)2.41858548
52Spastic tetraplegia (HP:0002510)2.35922588
53Spastic gait (HP:0002064)2.35632781
54Inability to walk (HP:0002540)2.33527061
55Muscular hypotonia of the trunk (HP:0008936)2.30789028
56Pachygyria (HP:0001302)2.30189125
57Akinesia (HP:0002304)2.30044726
58Amyotrophic lateral sclerosis (HP:0007354)2.29904572
59Urinary urgency (HP:0000012)2.29225720
60Dysmetria (HP:0001310)2.28949126
61Hyperthyroidism (HP:0000836)2.26912687
62Fetal akinesia sequence (HP:0001989)2.26737299
63Status epilepticus (HP:0002133)2.25836985
64Exotropia (HP:0000577)2.22738066
65Intention tremor (HP:0002080)2.22287143
66Cerebral inclusion bodies (HP:0100314)2.22227389
67Abnormality of the labia minora (HP:0012880)2.18323693
68Sleep apnea (HP:0010535)2.17327663
69Aplasia/Hypoplasia of the brainstem (HP:0007362)2.16387205
70Hypoplasia of the brainstem (HP:0002365)2.16387205
71Protruding tongue (HP:0010808)2.15907480
72Absent speech (HP:0001344)2.15860013
73Scanning speech (HP:0002168)2.15511709
74Hemiparesis (HP:0001269)2.15383058
75Congenital primary aphakia (HP:0007707)2.14874511
76Medial flaring of the eyebrow (HP:0010747)2.13500724
77Diplopia (HP:0000651)2.13309530
78Abnormality of binocular vision (HP:0011514)2.13309530
79Poor suck (HP:0002033)2.13060444
80Genetic anticipation (HP:0003743)2.12756255
81Type II lissencephaly (HP:0007260)2.12537797
82Specific learning disability (HP:0001328)2.11858233
83Inappropriate behavior (HP:0000719)2.11282660
84Impaired smooth pursuit (HP:0007772)2.06674007
85Neurofibrillary tangles (HP:0002185)2.04303804
86Impaired pain sensation (HP:0007328)2.03299692
87Abnormality of pain sensation (HP:0010832)2.03299692
88Torticollis (HP:0000473)2.02890345
89Bradykinesia (HP:0002067)2.02109962
90Nephrogenic diabetes insipidus (HP:0009806)2.01039972
91Lower limb muscle weakness (HP:0007340)1.98330695
92Abnormality of salivation (HP:0100755)1.98265088
93Prolonged QT interval (HP:0001657)1.96908305
94Esotropia (HP:0000565)1.95400709
95Genital tract atresia (HP:0001827)1.95384711
96Morphological abnormality of the pyramidal tract (HP:0002062)1.94481008
97Postural tremor (HP:0002174)1.92772075
98Stereotypic behavior (HP:0000733)1.91556111
99Narrow nasal bridge (HP:0000446)1.89588372
100Postural instability (HP:0002172)1.89370816
101Generalized hypopigmentation of hair (HP:0011358)1.88930264
102Paraplegia (HP:0010550)1.88687112
103Retinal dysplasia (HP:0007973)1.87883988
104Psychosis (HP:0000709)1.87589270
105Lissencephaly (HP:0001339)1.87294514
106Nephronophthisis (HP:0000090)1.86519040
107Focal dystonia (HP:0004373)1.86141462
108Vaginal atresia (HP:0000148)1.85071869
109Degeneration of the lateral corticospinal tracts (HP:0002314)1.84945782
110Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.84945782
111Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.84871121
112Hypoglycemic coma (HP:0001325)1.82899309
113Abnormal autonomic nervous system physiology (HP:0012332)1.80496330
114Abnormality of ocular smooth pursuit (HP:0000617)1.79385146
115Generalized myoclonic seizures (HP:0002123)1.78924048
116Impaired vibratory sensation (HP:0002495)1.77475030
117Hypoplasia of the corpus callosum (HP:0002079)1.75948696
118Craniofacial dystonia (HP:0012179)1.75679846
119Incomplete penetrance (HP:0003829)1.75198948
120Molar tooth sign on MRI (HP:0002419)1.73276475
121Abnormality of midbrain morphology (HP:0002418)1.73276475
122Ulnar claw (HP:0001178)1.71852380
123Intellectual disability, severe (HP:0010864)1.71616180
124Pancreatic fibrosis (HP:0100732)1.70073409
125Tented upper lip vermilion (HP:0010804)1.69745699

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.52628702
2NTRK33.96385236
3CASK3.82596023
4MAP3K43.24638172
5MAP3K93.21317075
6MAP2K72.85294574
7MINK12.80455207
8MAP3K122.71289874
9EPHA42.36594025
10NTRK12.24444934
11NTRK22.07456441
12DAPK22.01779403
13MAPK131.99485891
14MAP2K41.99207729
15PNCK1.79391187
16GRK51.79157529
17PLK21.72335106
18PAK61.70983845
19PINK11.53521199
20FRK1.41558680
21KSR11.41003781
22DAPK11.40577347
23CDK51.39199180
24UHMK11.38404019
25PHKG21.38171301
26PHKG11.38171301
27CAMKK21.35689420
28KSR21.34523335
29CDK191.29561297
30TNIK1.28615940
31PRKCG1.22610097
32SIK21.15701476
33CSNK1G21.14134692
34GRK71.13806653
35AKT31.13389560
36DYRK21.13367445
37EPHA31.12910868
38RIPK41.12811783
39CAMKK11.11485337
40ARAF1.10857338
41CAMK2A1.08110530
42PRPF4B1.05747132
43SGK2231.05578550
44SGK4941.05578550
45MAP3K21.01819732
46SGK20.93818391
47CDK140.92388920
48ERBB30.90924195
49CDK180.90066576
50PAK30.88549159
51CAMK2B0.87414732
52DYRK1A0.87366215
53FGFR20.86531748
54NME10.86277799
55MAP4K20.85931105
56CDK150.84320184
57LATS20.82594478
58CCNB10.82362676
59PRKCE0.82253956
60SIK30.81758138
61CSNK1G30.81049461
62BCR0.79985884
63RET0.79208004
64WNK30.78045866
65OXSR10.77597287
66ADRBK10.73800375
67GRK10.73169150
68CDK11A0.71976625
69TRIM280.70378936
70FES0.65527917
71RPS6KA20.62629272
72PRKD30.62171549
73MST1R0.61459950
74CAMK2D0.61081859
75STK110.60197056
76MAP2K10.59351078
77ADRBK20.58467750
78EPHB20.56070693
79LIMK10.56018781
80SGK10.55394910
81FER0.55219467
82SCYL20.54327084
83PRKCZ0.54101497
84SGK30.54042601
85PRKCH0.52869897
86BMPR20.52509909
87CSNK1E0.51378622
88MAP3K60.48939671
89MARK20.47962559
90BRAF0.47618036
91CAMK2G0.46280278
92STK380.45977870
93DYRK30.45191982
94BMPR1B0.42975253
95FGR0.42763313
96CAMK10.42735938
97CSNK1A10.41725524
98INSRR0.40955992
99CSNK1A1L0.40670194
100CSNK1G10.40063485
101PRKG10.38867854
102CAMK40.38597613
103PTK2B0.38305871
104MAP3K110.38117981
105CSNK1D0.37988075
106MAP3K10.37954009
107PRKACA0.37886258
108RPS6KA30.36929224
109TYRO30.36338517
110PRKCB0.36194417
111MKNK20.36085244
112CAMK1G0.35980885
113CDC42BPA0.35616093
114PKN10.33743031
115FYN0.33687685
116PRKACB0.33647184
117WNK40.32798462
118MAPK100.32354670
119TAOK10.32348249
120ERBB20.31258135
121CAMK1D0.30619139
122MAPK80.29372732
123PRKAA10.28336162
124GSK3B0.27910114
125STK390.26694647
126WNK10.25912960

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.96817537
2Synaptic vesicle cycle_Homo sapiens_hsa047213.69168942
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.74128733
4GABAergic synapse_Homo sapiens_hsa047272.67082779
5Circadian entrainment_Homo sapiens_hsa047132.51879145
6Amphetamine addiction_Homo sapiens_hsa050312.44740106
7Morphine addiction_Homo sapiens_hsa050322.44354730
8Olfactory transduction_Homo sapiens_hsa047402.39536897
9Long-term potentiation_Homo sapiens_hsa047202.37445780
10Collecting duct acid secretion_Homo sapiens_hsa049662.36935107
11Glutamatergic synapse_Homo sapiens_hsa047242.33909268
12Dopaminergic synapse_Homo sapiens_hsa047282.33223361
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11492995
14Insulin secretion_Homo sapiens_hsa049112.09587460
15Taste transduction_Homo sapiens_hsa047422.04160922
16Serotonergic synapse_Homo sapiens_hsa047262.02662141
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.99207421
18Cholinergic synapse_Homo sapiens_hsa047251.96640199
19Cocaine addiction_Homo sapiens_hsa050301.96518325
20Salivary secretion_Homo sapiens_hsa049701.83716551
21Long-term depression_Homo sapiens_hsa047301.76988470
22Renin secretion_Homo sapiens_hsa049241.75740330
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.74732985
24Vibrio cholerae infection_Homo sapiens_hsa051101.59403411
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56066285
26Gastric acid secretion_Homo sapiens_hsa049711.50833997
27Oxidative phosphorylation_Homo sapiens_hsa001901.47118013
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47105822
29Oxytocin signaling pathway_Homo sapiens_hsa049211.43769688
30Gap junction_Homo sapiens_hsa045401.37385956
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36183633
32Calcium signaling pathway_Homo sapiens_hsa040201.34200578
33GnRH signaling pathway_Homo sapiens_hsa049121.33628380
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29739028
35Cardiac muscle contraction_Homo sapiens_hsa042601.25695943
36Alzheimers disease_Homo sapiens_hsa050101.21201492
37Axon guidance_Homo sapiens_hsa043601.21164629
38Phototransduction_Homo sapiens_hsa047441.18411705
39Parkinsons disease_Homo sapiens_hsa050121.16437733
40Type II diabetes mellitus_Homo sapiens_hsa049301.10125569
41Estrogen signaling pathway_Homo sapiens_hsa049151.08474117
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06022134
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05146219
44Melanogenesis_Homo sapiens_hsa049161.05035512
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02669381
46cAMP signaling pathway_Homo sapiens_hsa040241.00741614
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92887354
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92382309
49ErbB signaling pathway_Homo sapiens_hsa040120.91164323
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89760812
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85887472
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.84900068
53Glioma_Homo sapiens_hsa052140.80683779
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78314941
55Ether lipid metabolism_Homo sapiens_hsa005650.78301875
56Oocyte meiosis_Homo sapiens_hsa041140.77603630
57Huntingtons disease_Homo sapiens_hsa050160.76222795
58Pancreatic secretion_Homo sapiens_hsa049720.74440078
59Protein export_Homo sapiens_hsa030600.74210533
60Thyroid hormone synthesis_Homo sapiens_hsa049180.72253567
61Alcoholism_Homo sapiens_hsa050340.71966135
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71756980
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71323664
64Dorso-ventral axis formation_Homo sapiens_hsa043200.63505570
65MAPK signaling pathway_Homo sapiens_hsa040100.61279609
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58636174
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57629067
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57622426
69Dilated cardiomyopathy_Homo sapiens_hsa054140.56828311
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56138044
71Circadian rhythm_Homo sapiens_hsa047100.55717484
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55047523
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.54977997
74Glucagon signaling pathway_Homo sapiens_hsa049220.54171783
75Type I diabetes mellitus_Homo sapiens_hsa049400.53584316
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53153748
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.52858451
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51996528
79Ras signaling pathway_Homo sapiens_hsa040140.50681601
80Phagosome_Homo sapiens_hsa041450.50582052
81Rheumatoid arthritis_Homo sapiens_hsa053230.49522706
82Choline metabolism in cancer_Homo sapiens_hsa052310.49470474
83Renal cell carcinoma_Homo sapiens_hsa052110.48316489
84Bile secretion_Homo sapiens_hsa049760.47788015
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44434556
86Vitamin B6 metabolism_Homo sapiens_hsa007500.44312474
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44203484
88Insulin signaling pathway_Homo sapiens_hsa049100.43177797
89Hedgehog signaling pathway_Homo sapiens_hsa043400.42232159
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42179094
91Tyrosine metabolism_Homo sapiens_hsa003500.40584245
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.40173678
93Endometrial cancer_Homo sapiens_hsa052130.39904314
94Steroid biosynthesis_Homo sapiens_hsa001000.39534304
95Prion diseases_Homo sapiens_hsa050200.38717773
96AMPK signaling pathway_Homo sapiens_hsa041520.38629834
97Mineral absorption_Homo sapiens_hsa049780.38476298
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38376949
99Prolactin signaling pathway_Homo sapiens_hsa049170.38037249
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37695827
101Inositol phosphate metabolism_Homo sapiens_hsa005620.37029238
102Ovarian steroidogenesis_Homo sapiens_hsa049130.36641777
103VEGF signaling pathway_Homo sapiens_hsa043700.35825743
104Wnt signaling pathway_Homo sapiens_hsa043100.34603053
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34536245
106Regulation of autophagy_Homo sapiens_hsa041400.34163662
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34064985
108Histidine metabolism_Homo sapiens_hsa003400.32810688
109mTOR signaling pathway_Homo sapiens_hsa041500.32748345
110Rap1 signaling pathway_Homo sapiens_hsa040150.32575834
111Linoleic acid metabolism_Homo sapiens_hsa005910.32437616
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31762087
113Hippo signaling pathway_Homo sapiens_hsa043900.30513022
114Colorectal cancer_Homo sapiens_hsa052100.30123761
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29092563
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28847764
117beta-Alanine metabolism_Homo sapiens_hsa004100.28265729
118Tight junction_Homo sapiens_hsa045300.28126269
119Butanoate metabolism_Homo sapiens_hsa006500.27464651

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