SYT16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.87680056
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.67546489
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.58952094
4vocalization behavior (GO:0071625)5.56018027
5neuron cell-cell adhesion (GO:0007158)5.49050281
6synaptic vesicle exocytosis (GO:0016079)5.40885168
7protein localization to synapse (GO:0035418)5.28514141
8regulation of glutamate receptor signaling pathway (GO:1900449)5.19716036
9locomotory exploration behavior (GO:0035641)5.17964977
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.10315879
11glutamate secretion (GO:0014047)5.07891584
12ionotropic glutamate receptor signaling pathway (GO:0035235)5.05023100
13synaptic vesicle maturation (GO:0016188)4.98827111
14regulation of synaptic vesicle exocytosis (GO:2000300)4.86929882
15glutamate receptor signaling pathway (GO:0007215)4.64984308
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.60897109
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.59914002
18exploration behavior (GO:0035640)4.58222710
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.49842355
20neuron recognition (GO:0008038)4.43494564
21regulation of synaptic vesicle transport (GO:1902803)4.40660558
22synaptic transmission, glutamatergic (GO:0035249)4.37091189
23neurotransmitter-gated ion channel clustering (GO:0072578)4.34900046
24regulation of neuronal synaptic plasticity (GO:0048168)4.29350173
25layer formation in cerebral cortex (GO:0021819)4.26181491
26neuron-neuron synaptic transmission (GO:0007270)4.18186431
27positive regulation of synapse maturation (GO:0090129)4.09356649
28presynaptic membrane assembly (GO:0097105)4.05323627
29dendritic spine morphogenesis (GO:0060997)4.04953672
30neurotransmitter secretion (GO:0007269)4.04259970
31regulation of synapse structural plasticity (GO:0051823)4.02896811
32regulation of excitatory postsynaptic membrane potential (GO:0060079)4.02593856
33neuronal action potential propagation (GO:0019227)4.00649364
34postsynaptic membrane organization (GO:0001941)3.99490233
35axonal fasciculation (GO:0007413)3.99016252
36proline transport (GO:0015824)3.93158854
37sodium ion export (GO:0071436)3.88725662
38gamma-aminobutyric acid signaling pathway (GO:0007214)3.87360749
39regulation of postsynaptic membrane potential (GO:0060078)3.84740269
40long-term memory (GO:0007616)3.82741190
41L-amino acid import (GO:0043092)3.79971202
42regulation of dendritic spine morphogenesis (GO:0061001)3.78192457
43positive regulation of membrane potential (GO:0045838)3.77376511
44presynaptic membrane organization (GO:0097090)3.75714432
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.73927370
46long-term synaptic potentiation (GO:0060291)3.70436786
47regulation of synaptic plasticity (GO:0048167)3.67149928
48membrane depolarization during action potential (GO:0086010)3.64244561
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.59116759
50G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.55688345
51regulation of synaptic transmission, glutamatergic (GO:0051966)3.53508545
52positive regulation of neurotransmitter secretion (GO:0001956)3.48427775
53behavioral defense response (GO:0002209)3.47159087
54behavioral fear response (GO:0001662)3.47159087
55synaptic vesicle endocytosis (GO:0048488)3.45208109
56response to histamine (GO:0034776)3.43345582
57G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.40576835
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.39943258
59positive regulation of dendritic spine morphogenesis (GO:0061003)3.38546925
60detection of calcium ion (GO:0005513)3.37335196
61positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.34317882
62cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.34022883
63regulation of neurotransmitter secretion (GO:0046928)3.33773509
64positive regulation of synaptic transmission, GABAergic (GO:0032230)3.33335597
65regulation of vesicle fusion (GO:0031338)3.33233841
66regulation of dendritic spine development (GO:0060998)3.31332021
67neurotransmitter transport (GO:0006836)3.30061544
68negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.29812879
69gamma-aminobutyric acid transport (GO:0015812)3.28622833
70regulation of synapse maturation (GO:0090128)3.26540949
71fear response (GO:0042596)3.26514470
72transmission of nerve impulse (GO:0019226)3.22653547
73serotonin metabolic process (GO:0042428)3.21447786
74innervation (GO:0060384)3.21016288
75positive regulation of dendritic spine development (GO:0060999)3.20882951
76righting reflex (GO:0060013)3.19956796
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.18306215
78dendrite morphogenesis (GO:0048813)3.16919212
79regulation of cilium movement (GO:0003352)3.16890047
80learning (GO:0007612)3.16217220
81negative regulation of dendrite morphogenesis (GO:0050774)3.16163950
82positive regulation of neurotransmitter transport (GO:0051590)3.16024354
83membrane depolarization (GO:0051899)3.14431613
84negative regulation of cytosolic calcium ion concentration (GO:0051481)3.14239930
85regulation of calcium ion-dependent exocytosis (GO:0017158)3.13310283
86negative regulation of dendrite development (GO:2000171)3.13144883
87startle response (GO:0001964)3.12978838
88positive regulation of synapse assembly (GO:0051965)3.12956154
89synapse assembly (GO:0007416)3.12157649
90C4-dicarboxylate transport (GO:0015740)3.11660224
91dendritic spine organization (GO:0097061)3.09691519
92amino acid import (GO:0043090)3.09150674
93calcium ion-dependent exocytosis (GO:0017156)3.07603489
94activation of protein kinase A activity (GO:0034199)3.07054367
95central nervous system projection neuron axonogenesis (GO:0021952)3.05905575
96vesicle transport along microtubule (GO:0047496)3.05650277
97regulation of glutamate secretion (GO:0014048)3.05510880
98regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.04881813
99cerebellar granule cell differentiation (GO:0021707)3.04437270
100regulation of neurotransmitter transport (GO:0051588)3.02805077
101positive regulation of synaptic transmission (GO:0050806)3.02040186
102auditory behavior (GO:0031223)3.01948083
103regulation of neurotransmitter levels (GO:0001505)3.01860669
104regulation of synaptic transmission (GO:0050804)3.01672622
105membrane hyperpolarization (GO:0060081)3.00567898
106positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.98690329
107retinal cone cell development (GO:0046549)2.96741874
108neuronal action potential (GO:0019228)2.95322241
109synaptic transmission (GO:0007268)2.95042494
110cellular potassium ion homeostasis (GO:0030007)2.94620172
111cell migration in hindbrain (GO:0021535)2.94558784
112cerebellar Purkinje cell differentiation (GO:0021702)2.92404636
113organelle transport along microtubule (GO:0072384)2.92320303
114social behavior (GO:0035176)2.91595091
115intraspecies interaction between organisms (GO:0051703)2.91595091
116primary amino compound metabolic process (GO:1901160)2.91151638
117long term synaptic depression (GO:0060292)2.91083372
118regulation of voltage-gated calcium channel activity (GO:1901385)2.89318915
119neuromuscular process controlling balance (GO:0050885)2.89107824
120cochlea development (GO:0090102)2.88593344
121adult walking behavior (GO:0007628)2.87316861
122central nervous system neuron axonogenesis (GO:0021955)2.87129721
123short-term memory (GO:0007614)2.85267381
124mechanosensory behavior (GO:0007638)2.84214493
125cellular sodium ion homeostasis (GO:0006883)2.83988674
126neuronal ion channel clustering (GO:0045161)2.77124301
127cell communication by electrical coupling (GO:0010644)2.77008211
128regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.72868967
129potassium ion homeostasis (GO:0055075)2.72692150
130neuromuscular process (GO:0050905)2.72478829

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.12486692
2GBX2_23144817_ChIP-Seq_PC3_Human4.05796308
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13621173
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10274206
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94881627
6REST_21632747_ChIP-Seq_MESCs_Mouse2.72439183
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64762975
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64762975
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62679520
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58527784
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.55006469
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51816355
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45478119
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40830862
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40060567
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.37569913
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.26301013
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25631896
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.17952008
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17417367
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15304091
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.15064431
23DROSHA_22980978_ChIP-Seq_HELA_Human2.15044341
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.14589836
25TAF15_26573619_Chip-Seq_HEK293_Human2.14315632
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02918101
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97429420
28AR_21572438_ChIP-Seq_LNCaP_Human1.95616650
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93721748
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87774570
31* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86912088
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83295004
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78211369
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76872358
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.75833257
36P300_19829295_ChIP-Seq_ESCs_Human1.63919522
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63917663
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60335373
39ZNF274_21170338_ChIP-Seq_K562_Hela1.57231419
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54540753
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.53549531
42* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50307714
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.47714536
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45448448
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45316180
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44796782
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41865411
48FUS_26573619_Chip-Seq_HEK293_Human1.41175536
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39465444
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39214662
51AR_25329375_ChIP-Seq_VCAP_Human1.39026482
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38545935
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38197260
54* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36630900
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.36249776
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35526853
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.35440474
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.35166603
59* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34772936
60* CBP_20019798_ChIP-Seq_JUKART_Human1.34772936
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34092661
62RNF2_27304074_Chip-Seq_NSC_Mouse1.31813416
63IGF1R_20145208_ChIP-Seq_DFB_Human1.30036241
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.29581781
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29033633
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.26495266
67STAT3_23295773_ChIP-Seq_U87_Human1.25666096
68VDR_22108803_ChIP-Seq_LS180_Human1.25420701
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.23764659
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22830627
71EWS_26573619_Chip-Seq_HEK293_Human1.19626915
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18273238
73LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17016385
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15502156
75AR_19668381_ChIP-Seq_PC3_Human1.15354908
76P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14766820
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14097647
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13962837
79* TCF4_23295773_ChIP-Seq_U87_Human1.13308941
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11023923
81* FLI1_21867929_ChIP-Seq_TH2_Mouse1.09850008
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.09399276
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.08693935
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08629162
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.08158025
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07707417
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.07407667
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07370277
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.06923132
90* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06635590
91RUNX2_22187159_ChIP-Seq_PCA_Human1.06303165
92P53_22387025_ChIP-Seq_ESCs_Mouse1.05677011
93TCF4_22108803_ChIP-Seq_LS180_Human1.05521824
94JUN_21703547_ChIP-Seq_K562_Human1.05261705
95* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04967421
96ER_23166858_ChIP-Seq_MCF-7_Human1.04233087
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03575766
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03575766
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03573238
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02829133
101AHR_22903824_ChIP-Seq_MCF-7_Human1.00885615
102* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00475629
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00112902
104CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99717240
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98939509
106NANOG_18555785_Chip-Seq_ESCs_Mouse0.98174555
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97250081
108* TP53_18474530_ChIP-ChIP_U2OS_Human0.96889410
109BCAT_22108803_ChIP-Seq_LS180_Human0.96205259
110TP53_16413492_ChIP-PET_HCT116_Human0.95737189
111RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92692957
112SMAD3_21741376_ChIP-Seq_ESCs_Human0.91992032
113DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91115364
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89563620
115KDM2B_26808549_Chip-Seq_REH_Human0.88259699
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87149086
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.86898287

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.41090809
2MP0003880_abnormal_central_pattern5.44913102
3MP0003635_abnormal_synaptic_transmissio4.15143658
4MP0004270_analgesia3.80110561
5MP0002063_abnormal_learning/memory/cond3.52014994
6MP0009745_abnormal_behavioral_response3.47363587
7MP0002064_seizures3.11350860
8MP0001968_abnormal_touch/_nociception3.10127161
9MP0002572_abnormal_emotion/affect_behav2.95316829
10MP0005423_abnormal_somatic_nervous2.66325508
11MP0009046_muscle_twitch2.64876956
12MP0002734_abnormal_mechanical_nocicepti2.62770446
13MP0002822_catalepsy2.57250633
14MP0002736_abnormal_nociception_after2.54687601
15MP0001486_abnormal_startle_reflex2.53245286
16MP0002272_abnormal_nervous_system2.47180139
17MP0002735_abnormal_chemical_nociception2.31126681
18MP0001440_abnormal_grooming_behavior2.28004242
19MP0001501_abnormal_sleep_pattern2.22890059
20MP0000778_abnormal_nervous_system2.20981938
21MP0008877_abnormal_DNA_methylation2.13696206
22MP0002733_abnormal_thermal_nociception2.09226067
23MP0002184_abnormal_innervation1.98661696
24MP0001970_abnormal_pain_threshold1.95737670
25MP0002067_abnormal_sensory_capabilities1.94794137
26MP0003329_amyloid_beta_deposits1.94427604
27MP0006276_abnormal_autonomic_nervous1.92986268
28MP0002557_abnormal_social/conspecific_i1.81231798
29MP0005386_behavior/neurological_phenoty1.78778115
30MP0004924_abnormal_behavior1.78778115
31MP0001529_abnormal_vocalization1.72477557
32MP0004811_abnormal_neuron_physiology1.70880372
33MP0009780_abnormal_chondrocyte_physiolo1.70605282
34MP0005646_abnormal_pituitary_gland1.63034329
35MP0003879_abnormal_hair_cell1.62699656
36MP0003787_abnormal_imprinting1.61280580
37MP0004858_abnormal_nervous_system1.59803372
38MP0001984_abnormal_olfaction1.57904837
39MP0008569_lethality_at_weaning1.55298452
40MP0000955_abnormal_spinal_cord1.51274198
41MP0005645_abnormal_hypothalamus_physiol1.48765295
42MP0002909_abnormal_adrenal_gland1.47479005
43MP0002882_abnormal_neuron_morphology1.41716718
44MP0002066_abnormal_motor_capabilities/c1.39941460
45MP0001905_abnormal_dopamine_level1.38151210
46MP0004885_abnormal_endolymph1.32644847
47MP0001502_abnormal_circadian_rhythm1.25553998
48MP0002837_dystrophic_cardiac_calcinosis1.24580230
49MP0003122_maternal_imprinting1.19383174
50MP0001188_hyperpigmentation1.18962241
51MP0002152_abnormal_brain_morphology1.16381333
52MP0010386_abnormal_urinary_bladder1.15451945
53MP0003633_abnormal_nervous_system1.15157800
54MP0005410_abnormal_fertilization1.07515658
55MP0004742_abnormal_vestibular_system1.05513008
56MP0000751_myopathy1.03288189
57MP0004142_abnormal_muscle_tone1.02880257
58MP0003631_nervous_system_phenotype1.01815832
59MP0005394_taste/olfaction_phenotype1.00310551
60MP0005499_abnormal_olfactory_system1.00310551
61MP0003690_abnormal_glial_cell0.98881821
62MP0002069_abnormal_eating/drinking_beha0.96160074
63MP0004043_abnormal_pH_regulation0.94724441
64MP0004147_increased_porphyrin_level0.94581312
65MP0000631_abnormal_neuroendocrine_gland0.94394508
66MP0002876_abnormal_thyroid_physiology0.91393502
67MP0000920_abnormal_myelination0.90488023
68MP0001963_abnormal_hearing_physiology0.90357447
69MP0001986_abnormal_taste_sensitivity0.89263826
70MP0003718_maternal_effect0.86903795
71MP0006292_abnormal_olfactory_placode0.86900199
72MP0000604_amyloidosis0.86124845
73MP0002229_neurodegeneration0.85514299
74MP0008872_abnormal_physiological_respon0.85244005
75MP0004085_abnormal_heartbeat0.82481882
76MP0005551_abnormal_eye_electrophysiolog0.82300839
77MP0004145_abnormal_muscle_electrophysio0.81007923
78MP0002752_abnormal_somatic_nervous0.80503580
79MP0005535_abnormal_body_temperature0.80328721
80MP0005253_abnormal_eye_physiology0.80047195
81MP0008874_decreased_physiological_sensi0.78370064
82MP0000569_abnormal_digit_pigmentation0.78361545
83MP0001664_abnormal_digestion0.77016436
84MP0003698_abnormal_male_reproductive0.73189891
85MP0002102_abnormal_ear_morphology0.71866063
86MP0003861_abnormal_nervous_system0.71307063
87MP0000013_abnormal_adipose_tissue0.71275395
88MP0001485_abnormal_pinna_reflex0.70928883
89MP0001177_atelectasis0.70754398
90MP0005409_darkened_coat_color0.69692058
91MP0004484_altered_response_of0.68490825
92MP0003634_abnormal_glial_cell0.68329554
93MP0003632_abnormal_nervous_system0.68280071
94MP0000427_abnormal_hair_cycle0.67417306
95MP0000026_abnormal_inner_ear0.66073927
96MP0001348_abnormal_lacrimal_gland0.64550424
97MP0003890_abnormal_embryonic-extraembry0.64069089
98MP0003283_abnormal_digestive_organ0.63117824
99MP0004215_abnormal_myocardial_fiber0.62181046
100MP0005187_abnormal_penis_morphology0.61129665
101MP0004510_myositis0.58165493
102MP0003119_abnormal_digestive_system0.57125310
103MP0003137_abnormal_impulse_conducting0.57020725
104MP0003938_abnormal_ear_development0.56566630
105MP0001943_abnormal_respiration0.55805694
106MP0002638_abnormal_pupillary_reflex0.54611439
107MP0002234_abnormal_pharynx_morphology0.52833814
108MP0003121_genomic_imprinting0.52189589
109MP0002082_postnatal_lethality0.50457600
110MP0010770_preweaning_lethality0.50457600
111MP0010769_abnormal_survival0.49865068
112MP0008789_abnormal_olfactory_epithelium0.49794591
113MP0004233_abnormal_muscle_weight0.49264165
114MP0002751_abnormal_autonomic_nervous0.49179352
115MP0003956_abnormal_body_size0.48740473

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.80157741
2Myokymia (HP:0002411)6.12447093
3Focal seizures (HP:0007359)5.76169877
4Epileptic encephalopathy (HP:0200134)5.22266189
5Visual hallucinations (HP:0002367)5.13691449
6Atonic seizures (HP:0010819)4.70868185
7Hyperventilation (HP:0002883)4.41273780
8Absence seizures (HP:0002121)4.29452890
9Febrile seizures (HP:0002373)4.25698729
10Dialeptic seizures (HP:0011146)3.90989324
11Broad-based gait (HP:0002136)3.90703776
12Generalized tonic-clonic seizures (HP:0002069)3.82141045
13Progressive cerebellar ataxia (HP:0002073)3.68123689
14Amblyopia (HP:0000646)3.58587896
15Poor eye contact (HP:0000817)3.39471099
16Drooling (HP:0002307)3.29638007
17Excessive salivation (HP:0003781)3.29638007
18Supranuclear gaze palsy (HP:0000605)3.23546999
19Impaired vibration sensation in the lower limbs (HP:0002166)3.15324979
20Cerebral inclusion bodies (HP:0100314)3.14973274
21Mutism (HP:0002300)3.14803393
22Epileptiform EEG discharges (HP:0011182)3.00281607
23Abnormal eating behavior (HP:0100738)2.99618179
24Neurofibrillary tangles (HP:0002185)2.95809572
25Impaired social interactions (HP:0000735)2.91288008
26Abnormal social behavior (HP:0012433)2.91288008
27Gaze-evoked nystagmus (HP:0000640)2.88811089
28Truncal ataxia (HP:0002078)2.86344669
29Anxiety (HP:0000739)2.84747089
30Ankle clonus (HP:0011448)2.84341601
31Polyphagia (HP:0002591)2.82245525
32Action tremor (HP:0002345)2.81257160
33EEG with generalized epileptiform discharges (HP:0011198)2.80190438
34Depression (HP:0000716)2.79195946
35Amyotrophic lateral sclerosis (HP:0007354)2.76191412
36Dysmetria (HP:0001310)2.75182120
37Progressive inability to walk (HP:0002505)2.71346579
38Absent speech (HP:0001344)2.69257546
39Urinary bladder sphincter dysfunction (HP:0002839)2.68797799
40Dysdiadochokinesis (HP:0002075)2.66735038
41Fetal akinesia sequence (HP:0001989)2.62481592
42Hypsarrhythmia (HP:0002521)2.61999296
43Papilledema (HP:0001085)2.57357907
44Gait imbalance (HP:0002141)2.53859018
45Stereotypic behavior (HP:0000733)2.53777844
46Urinary urgency (HP:0000012)2.51939914
47Inability to walk (HP:0002540)2.49752540
48Limb dystonia (HP:0002451)2.49073209
49Insidious onset (HP:0003587)2.46889314
50Termporal pattern (HP:0011008)2.46889314
51Abnormality of binocular vision (HP:0011514)2.44803610
52Diplopia (HP:0000651)2.44803610
53Spastic gait (HP:0002064)2.41706976
54Hemiparesis (HP:0001269)2.41091109
55Protruding tongue (HP:0010808)2.40221033
56Abnormality of the corticospinal tract (HP:0002492)2.39827372
57Impaired smooth pursuit (HP:0007772)2.36935566
58Abnormality of the lower motor neuron (HP:0002366)2.29454121
59Postural instability (HP:0002172)2.26284948
60Torticollis (HP:0000473)2.26071704
61Genetic anticipation (HP:0003743)2.23541090
62Abnormality of salivation (HP:0100755)2.22966182
63Akinesia (HP:0002304)2.21519864
64Generalized myoclonic seizures (HP:0002123)2.16235956
65Delusions (HP:0000746)2.15584726
66Hemiplegia (HP:0002301)2.13875874
67Sleep apnea (HP:0010535)2.13852280
68Focal dystonia (HP:0004373)2.13742957
69Bradykinesia (HP:0002067)2.13474676
70Obstructive sleep apnea (HP:0002870)2.12709551
71Blue irides (HP:0000635)2.10589002
72Fair hair (HP:0002286)2.09807300
73Impaired vibratory sensation (HP:0002495)2.07566439
74Inappropriate behavior (HP:0000719)2.06341708
75Scanning speech (HP:0002168)2.06124443
76Pancreatic fibrosis (HP:0100732)2.04832519
77Pheochromocytoma (HP:0002666)2.03903190
78Volvulus (HP:0002580)2.02534213
79Lower limb muscle weakness (HP:0007340)2.00652560
80Pancreatic cysts (HP:0001737)2.00329249
81Specific learning disability (HP:0001328)2.00113433
82Widely spaced teeth (HP:0000687)1.98954740
83Generalized hypopigmentation of hair (HP:0011358)1.97639572
84Agitation (HP:0000713)1.96357807
85Spastic tetraplegia (HP:0002510)1.96216178
86Status epilepticus (HP:0002133)1.95837571
87Abnormality of ocular smooth pursuit (HP:0000617)1.95680768
88Congenital primary aphakia (HP:0007707)1.93387595
89Hypoplasia of the brainstem (HP:0002365)1.91407244
90Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91407244
91Molar tooth sign on MRI (HP:0002419)1.91169942
92Abnormality of midbrain morphology (HP:0002418)1.91169942
93Type II lissencephaly (HP:0007260)1.90951996
94Urethral obstruction (HP:0000796)1.90655800
95Incomplete penetrance (HP:0003829)1.90008758
96Genital tract atresia (HP:0001827)1.89621186
97True hermaphroditism (HP:0010459)1.89049641
98Megalencephaly (HP:0001355)1.87953006
99Thickened helices (HP:0000391)1.87852003
100Medial flaring of the eyebrow (HP:0010747)1.86675548
101Increased circulating renin level (HP:0000848)1.86492454
102Shoulder girdle muscle weakness (HP:0003547)1.85896480
103Craniofacial dystonia (HP:0012179)1.85885929
104Nephronophthisis (HP:0000090)1.84904454
105Dysmetric saccades (HP:0000641)1.84799929
106Dynein arm defect of respiratory motile cilia (HP:0012255)1.84335886
107Absent/shortened dynein arms (HP:0200106)1.84335886
108Hydroureter (HP:0000072)1.83974777
109Lissencephaly (HP:0001339)1.82455508
110Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80668340
111Gait ataxia (HP:0002066)1.80000605
112Nephrogenic diabetes insipidus (HP:0009806)1.79988697
113Neuroendocrine neoplasm (HP:0100634)1.79965560
114Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79225876
115Degeneration of the lateral corticospinal tracts (HP:0002314)1.79225876
116Retinal dysplasia (HP:0007973)1.79010169
117Intention tremor (HP:0002080)1.78355928
118Optic nerve hypoplasia (HP:0000609)1.78341755
119Abnormality of the labia minora (HP:0012880)1.77650484
120Vaginal atresia (HP:0000148)1.76694021
121Poor coordination (HP:0002370)1.76327141
122Syncope (HP:0001279)1.76007054
123Apathy (HP:0000741)1.75050561
124Morphological abnormality of the pyramidal tract (HP:0002062)1.73086233

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.39418769
2NTRK34.29238377
3MARK13.93570607
4MAP3K93.65594925
5FRK3.50578295
6NEK13.45199633
7MAP3K43.14968663
8CASK3.02861165
9MAP2K72.81410475
10MINK12.50871530
11RIPK42.46181342
12DAPK22.45066061
13MAP3K122.16719116
14NTRK22.04307492
15KSR11.95073462
16PAK61.93350190
17MAP2K41.85340942
18PLK21.85215936
19KSR21.85113501
20MAPK131.82981101
21PNCK1.81935874
22DAPK11.78046224
23MAP4K21.59580750
24ARAF1.57901262
25CDK191.52481661
26CDK51.50677743
27SIK21.48173733
28NTRK11.46247149
29PRKD31.37494852
30GRK51.36581255
31CAMKK11.36472822
32PRPF4B1.35671980
33BMPR21.26823830
34UHMK11.21612025
35TNIK1.18180826
36PRKCG1.17863030
37BMPR1B1.14853134
38CAMK2A1.11997013
39MAP3K131.03591876
40LATS21.01001211
41NME11.00410692
42CAMK2B0.99265227
43RAF10.97700160
44PHKG20.96682841
45PHKG10.96682841
46DYRK1A0.96633026
47PTK2B0.96362955
48FES0.94174425
49TYRO30.93676008
50CDK180.92444784
51CAMKK20.91368695
52CDK150.88324360
53CDK140.85874246
54OXSR10.83934764
55WNK30.82450322
56MAP3K20.78839501
57SGK2230.78420691
58SGK4940.78420691
59CCNB10.77026071
60PAK30.76901606
61NEK20.76610844
62CSNK1G20.76385609
63CDK11A0.76202135
64INSRR0.75450557
65MAP3K60.74394056
66CAMK10.73635045
67CSNK1G30.72965478
68CSNK1G10.72786945
69ACVR1B0.72722806
70STK110.72019145
71STK380.69854473
72PLK40.68917638
73ADRBK20.68825650
74STK390.66319745
75SGK20.66233615
76FGR0.66232730
77BRAF0.65920715
78LMTK20.65077505
79TAOK30.63169214
80SGK10.63086325
81STK38L0.62469165
82CSNK1A1L0.62297655
83DYRK20.62187656
84RET0.61616001
85TRIM280.60003579
86NEK60.58971067
87MARK20.57243552
88PRKCE0.54707550
89PRKCZ0.53294264
90CSNK1D0.52675095
91GRK70.51469487
92GRK10.51044858
93PRKCH0.48943741
94BCR0.48624808
95PRKACB0.46132225
96ERBB30.45725359
97AKT30.45621136
98MAP2K10.44338782
99PRKG10.44232155
100SIK30.43859054
101CDK30.43377395
102CAMK2D0.42424515
103BRD40.41885016
104TAOK10.41682628
105PDK10.40849014
106PDPK10.40824946
107CSNK1A10.40383255
108FGFR20.39653811
109CSNK1E0.38286229
110SGK30.38217076
111MAPKAPK50.37257178
112PINK10.37161679
113CAMK1G0.37123628
114WNK10.36958946
115RPS6KA30.36824613
116CAMK2G0.35623179
117MAPK100.34986209
118DAPK30.34475315
119CAMK40.34336576
120FER0.34313039
121DMPK0.34034015
122FYN0.33847244
123MAPK120.33507206
124PKN10.31265568
125ROCK20.30758825
126MAP3K10.30649460
127ADRBK10.29986251
128RPS6KA20.27910855

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.14824761
2Synaptic vesicle cycle_Homo sapiens_hsa047213.18418036
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.88692246
4Long-term potentiation_Homo sapiens_hsa047202.82968194
5Circadian entrainment_Homo sapiens_hsa047132.73702359
6Glutamatergic synapse_Homo sapiens_hsa047242.65486557
7GABAergic synapse_Homo sapiens_hsa047272.65312405
8Olfactory transduction_Homo sapiens_hsa047402.62863338
9Amphetamine addiction_Homo sapiens_hsa050312.61575241
10Morphine addiction_Homo sapiens_hsa050322.56805108
11Dopaminergic synapse_Homo sapiens_hsa047282.27852108
12Salivary secretion_Homo sapiens_hsa049702.14714521
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02889886
14Taste transduction_Homo sapiens_hsa047421.96868471
15Collecting duct acid secretion_Homo sapiens_hsa049661.91682385
16Insulin secretion_Homo sapiens_hsa049111.91298546
17Serotonergic synapse_Homo sapiens_hsa047261.87050176
18Cholinergic synapse_Homo sapiens_hsa047251.86975969
19Gastric acid secretion_Homo sapiens_hsa049711.83392186
20Renin secretion_Homo sapiens_hsa049241.81278703
21Long-term depression_Homo sapiens_hsa047301.80564480
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72634067
23Oxytocin signaling pathway_Homo sapiens_hsa049211.71577187
24Cocaine addiction_Homo sapiens_hsa050301.64657855
25Calcium signaling pathway_Homo sapiens_hsa040201.63061307
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55875633
27GnRH signaling pathway_Homo sapiens_hsa049121.46482127
28Axon guidance_Homo sapiens_hsa043601.41436723
29Gap junction_Homo sapiens_hsa045401.40468215
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32032606
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28014142
32cAMP signaling pathway_Homo sapiens_hsa040241.26602401
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23740921
34Vibrio cholerae infection_Homo sapiens_hsa051101.21517606
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20838970
36Estrogen signaling pathway_Homo sapiens_hsa049151.12898275
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12349649
38Butanoate metabolism_Homo sapiens_hsa006501.11515728
39Glioma_Homo sapiens_hsa052141.11046213
40ErbB signaling pathway_Homo sapiens_hsa040121.07716403
41Cardiac muscle contraction_Homo sapiens_hsa042601.04295482
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03495093
43Melanogenesis_Homo sapiens_hsa049161.03043954
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02139930
45Type II diabetes mellitus_Homo sapiens_hsa049300.98610987
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91639108
47Vitamin B6 metabolism_Homo sapiens_hsa007500.91421984
48Phototransduction_Homo sapiens_hsa047440.90612528
49Oocyte meiosis_Homo sapiens_hsa041140.90399506
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.89546373
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.87633870
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83272667
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81941923
54Alzheimers disease_Homo sapiens_hsa050100.80557991
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80225866
56Pancreatic secretion_Homo sapiens_hsa049720.77152134
57Choline metabolism in cancer_Homo sapiens_hsa052310.77091187
58Bile secretion_Homo sapiens_hsa049760.75774683
59VEGF signaling pathway_Homo sapiens_hsa043700.74038337
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.72677487
61MAPK signaling pathway_Homo sapiens_hsa040100.71628599
62Oxidative phosphorylation_Homo sapiens_hsa001900.71451340
63Dorso-ventral axis formation_Homo sapiens_hsa043200.70523205
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67930612
65Fatty acid biosynthesis_Homo sapiens_hsa000610.66414634
66Ras signaling pathway_Homo sapiens_hsa040140.64656881
67Thyroid hormone synthesis_Homo sapiens_hsa049180.62969941
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62364402
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61739622
70Ether lipid metabolism_Homo sapiens_hsa005650.61227468
71Dilated cardiomyopathy_Homo sapiens_hsa054140.61200927
72Glucagon signaling pathway_Homo sapiens_hsa049220.60335733
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59126378
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.56845031
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56255183
76Regulation of autophagy_Homo sapiens_hsa041400.55865246
77Nitrogen metabolism_Homo sapiens_hsa009100.55228570
78Rap1 signaling pathway_Homo sapiens_hsa040150.54790043
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54752298
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54701702
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.54141102
82Alcoholism_Homo sapiens_hsa050340.53184683
83Wnt signaling pathway_Homo sapiens_hsa043100.51290890
84ABC transporters_Homo sapiens_hsa020100.50684977
85Renal cell carcinoma_Homo sapiens_hsa052110.49135193
86Type I diabetes mellitus_Homo sapiens_hsa049400.46275259
87Circadian rhythm_Homo sapiens_hsa047100.45899717
88African trypanosomiasis_Homo sapiens_hsa051430.44429475
89Endometrial cancer_Homo sapiens_hsa052130.44373813
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44000848
91Parkinsons disease_Homo sapiens_hsa050120.43584248
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43128269
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42466724
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42057328
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41187218
96Non-small cell lung cancer_Homo sapiens_hsa052230.41066287
97Inositol phosphate metabolism_Homo sapiens_hsa005620.40579530
98Prion diseases_Homo sapiens_hsa050200.39690598
99Hippo signaling pathway_Homo sapiens_hsa043900.39339697
100Colorectal cancer_Homo sapiens_hsa052100.39009141
101mTOR signaling pathway_Homo sapiens_hsa041500.38077772
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37513910
103beta-Alanine metabolism_Homo sapiens_hsa004100.37232456
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37108073
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36602948
106Basal transcription factors_Homo sapiens_hsa030220.36500002
107Huntingtons disease_Homo sapiens_hsa050160.35498505
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33648626
109Sphingolipid metabolism_Homo sapiens_hsa006000.33547645
110Endocytosis_Homo sapiens_hsa041440.33422420
111Ovarian steroidogenesis_Homo sapiens_hsa049130.32937849
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31868426
113Mineral absorption_Homo sapiens_hsa049780.31670375
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.31452137
115Insulin signaling pathway_Homo sapiens_hsa049100.31305851
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30439994
117Hedgehog signaling pathway_Homo sapiens_hsa043400.29709060
118Rheumatoid arthritis_Homo sapiens_hsa053230.29482713
119Tight junction_Homo sapiens_hsa045300.28095207
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27943547
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26566657

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