SYS1-DBNDD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.30327387
2cullin deneddylation (GO:0010388)4.09799278
3positive regulation of mitochondrial fission (GO:0090141)3.91692386
4protein deneddylation (GO:0000338)3.83742852
5mannosylation (GO:0097502)3.68706458
6pyrimidine nucleobase catabolic process (GO:0006208)3.62611227
7protein localization to cilium (GO:0061512)3.44867793
8sequestering of actin monomers (GO:0042989)3.30822825
9intraciliary transport (GO:0042073)3.30686515
10ATP hydrolysis coupled proton transport (GO:0015991)3.28186790
11energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.28186790
12synaptic vesicle maturation (GO:0016188)3.24077628
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.19371662
14nonmotile primary cilium assembly (GO:0035058)3.15275060
15termination of RNA polymerase III transcription (GO:0006386)3.15226515
16transcription elongation from RNA polymerase III promoter (GO:0006385)3.15226515
17glycosphingolipid biosynthetic process (GO:0006688)3.13557234
18regulation of short-term neuronal synaptic plasticity (GO:0048172)3.10534581
19neuron cell-cell adhesion (GO:0007158)3.07259174
20neuronal action potential propagation (GO:0019227)3.06950676
21nucleobase catabolic process (GO:0046113)3.04620443
22iron-sulfur cluster assembly (GO:0016226)3.01428851
23metallo-sulfur cluster assembly (GO:0031163)3.01428851
24glutamate secretion (GO:0014047)3.01238347
25protein complex biogenesis (GO:0070271)3.01133274
26L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.97799111
27mitochondrial respiratory chain complex I assembly (GO:0032981)2.93665476
28NADH dehydrogenase complex assembly (GO:0010257)2.93665476
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93665476
30synaptic vesicle exocytosis (GO:0016079)2.93291530
31regulation of cilium movement (GO:0003352)2.92905273
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.89886597
33axonal fasciculation (GO:0007413)2.89080986
34short-term memory (GO:0007614)2.88964320
35establishment of mitochondrion localization (GO:0051654)2.87956799
367-methylguanosine mRNA capping (GO:0006370)2.87484138
37neurofilament cytoskeleton organization (GO:0060052)2.86880543
38protein-cofactor linkage (GO:0018065)2.86577388
39synaptic transmission, glutamatergic (GO:0035249)2.80010336
40fatty acid elongation (GO:0030497)2.79581027
41RNA capping (GO:0036260)2.78818916
427-methylguanosine RNA capping (GO:0009452)2.78818916
43inner mitochondrial membrane organization (GO:0007007)2.77697245
44vocalization behavior (GO:0071625)2.77184639
45startle response (GO:0001964)2.76528281
46regulation of feeding behavior (GO:0060259)2.75013681
47negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.74902612
48regulation of synaptic vesicle exocytosis (GO:2000300)2.74009318
49dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.71358053
50DNA damage response, detection of DNA damage (GO:0042769)2.69576432
51neuron-neuron synaptic transmission (GO:0007270)2.69047091
52respiratory electron transport chain (GO:0022904)2.68610448
53negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.68090434
54regulation of cellular amino acid metabolic process (GO:0006521)2.67587344
55regulation of mitochondrial fission (GO:0090140)2.65907687
56electron transport chain (GO:0022900)2.65475908
57inner ear receptor stereocilium organization (GO:0060122)2.65290398
58negative regulation of oligodendrocyte differentiation (GO:0048715)2.65223253
59histone H2A acetylation (GO:0043968)2.64932396
60positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.64734022
61ionotropic glutamate receptor signaling pathway (GO:0035235)2.64580436
62gamma-aminobutyric acid transport (GO:0015812)2.63864920
63neurotransmitter secretion (GO:0007269)2.63326960
64detection of calcium ion (GO:0005513)2.62911015
65positive regulation of TOR signaling (GO:0032008)2.61815390
66mitochondrial respiratory chain complex assembly (GO:0033108)2.58967222
67protein K11-linked ubiquitination (GO:0070979)2.58634438
68platelet dense granule organization (GO:0060155)2.56919883
69establishment of viral latency (GO:0019043)2.53895029
70dendritic spine organization (GO:0097061)2.53505337
71de novo protein folding (GO:0006458)2.52673768
72protein insertion into membrane (GO:0051205)2.52639285
73protein localization to synapse (GO:0035418)2.52506797
74glutamate receptor signaling pathway (GO:0007215)2.52427884
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.52074580
76regulation of synapse structural plasticity (GO:0051823)2.51872686
77DNA double-strand break processing (GO:0000729)2.51490655
78negative regulation of ligase activity (GO:0051352)2.50692442
79negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.50692442
80organelle disassembly (GO:1903008)2.50530633
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.50065527
82tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50065527
83establishment of protein localization to mitochondrial membrane (GO:0090151)2.49670588
84ATP synthesis coupled proton transport (GO:0015986)2.49319846
85energy coupled proton transport, down electrochemical gradient (GO:0015985)2.49319846
86amino acid salvage (GO:0043102)2.47721496
87L-methionine salvage (GO:0071267)2.47721496
88L-methionine biosynthetic process (GO:0071265)2.47721496
89negative regulation of synaptic transmission, GABAergic (GO:0032229)2.46100911
90regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.46072827
91righting reflex (GO:0060013)2.42852952
92establishment of melanosome localization (GO:0032401)2.41720621
93C-terminal protein amino acid modification (GO:0018410)2.41097010
94cilium morphogenesis (GO:0060271)2.40653007
95regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.40438781
96regulation of mitotic spindle checkpoint (GO:1903504)2.40438781
97de novo posttranslational protein folding (GO:0051084)2.40319130
98neurotransmitter-gated ion channel clustering (GO:0072578)2.40252015
99negative regulation of cation channel activity (GO:2001258)2.39846680
100regulation of neurotransmitter uptake (GO:0051580)2.39044502

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.70258365
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.77148571
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.54295467
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.26755896
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.00452826
6ZNF274_21170338_ChIP-Seq_K562_Hela2.87628499
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.86296439
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.72952473
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.63692572
10GBX2_23144817_ChIP-Seq_PC3_Human2.60649104
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.54713260
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.45666133
13IGF1R_20145208_ChIP-Seq_DFB_Human2.42275558
14PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31322124
15EZH2_22144423_ChIP-Seq_EOC_Human2.20512790
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.14287982
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13277913
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04975772
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04615527
20VDR_23849224_ChIP-Seq_CD4+_Human2.04311095
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96642360
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95396795
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88438025
24ELK1_19687146_ChIP-ChIP_HELA_Human1.84449503
25DCP1A_22483619_ChIP-Seq_HELA_Human1.82602802
26GABP_19822575_ChIP-Seq_HepG2_Human1.80541664
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80493278
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73367484
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72105270
30IRF1_19129219_ChIP-ChIP_H3396_Human1.71024874
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65944422
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62883915
33VDR_22108803_ChIP-Seq_LS180_Human1.61562550
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.60471478
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.57443196
36DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.55789091
37TAF15_26573619_Chip-Seq_HEK293_Human1.55058232
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53232349
39FOXP3_21729870_ChIP-Seq_TREG_Human1.51384565
40FUS_26573619_Chip-Seq_HEK293_Human1.49866753
41P300_19829295_ChIP-Seq_ESCs_Human1.47743086
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40776402
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39714549
44FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.39398492
45REST_21632747_ChIP-Seq_MESCs_Mouse1.38511374
46MYC_18940864_ChIP-ChIP_HL60_Human1.37802047
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.36807814
48RNF2_27304074_Chip-Seq_NSC_Mouse1.35492689
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33862085
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30106049
51ELK1_22589737_ChIP-Seq_MCF10A_Human1.26426135
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24346600
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.22200499
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18993147
55EED_16625203_ChIP-ChIP_MESCs_Mouse1.17379437
56TP53_22573176_ChIP-Seq_HFKS_Human1.17327339
57PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.12973392
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11968727
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10711492
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09648747
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07843063
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.07707286
63EWS_26573619_Chip-Seq_HEK293_Human1.07397402
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06206192
65RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05716255
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05693481
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05680617
68SMAD4_21799915_ChIP-Seq_A2780_Human1.03396486
69AR_25329375_ChIP-Seq_VCAP_Human1.03084266
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01915228
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00520591
72SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99884734
73TTF2_22483619_ChIP-Seq_HELA_Human0.99250716
74SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98536155
75CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98313022
76XRN2_22483619_ChIP-Seq_HELA_Human0.97879847
77TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97309560
78EZH2_27304074_Chip-Seq_ESCs_Mouse0.97271825
79NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95956165
80REST_19997604_ChIP-ChIP_NEURONS_Mouse0.95255468
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94736937
82MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92795866
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91123836
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91101180
85NOTCH1_21737748_ChIP-Seq_TLL_Human0.90671581
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88918768
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88203185
88PIAS1_25552417_ChIP-Seq_VCAP_Human0.87376485
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86717972
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84869871
91CBP_20019798_ChIP-Seq_JUKART_Human0.84869871
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83893417
93SMAD3_21741376_ChIP-Seq_EPCs_Human0.83679992
94HTT_18923047_ChIP-ChIP_STHdh_Human0.83521062
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82753350
96RUNX2_22187159_ChIP-Seq_PCA_Human0.82080207
97TAL1_26923725_Chip-Seq_HPCs_Mouse0.81795845
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.80955648
99ER_23166858_ChIP-Seq_MCF-7_Human0.80378404
100TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79480718

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.71953247
2MP0004270_analgesia3.32795689
3MP0001529_abnormal_vocalization3.16593123
4MP0004859_abnormal_synaptic_plasticity3.00069834
5MP0002822_catalepsy2.91432404
6MP0003122_maternal_imprinting2.50371177
7MP0009046_muscle_twitch2.40051701
8MP0000778_abnormal_nervous_system2.26311333
9MP0001984_abnormal_olfaction2.23386999
10MP0003635_abnormal_synaptic_transmissio2.15927085
11MP0002272_abnormal_nervous_system2.14902291
12MP0003121_genomic_imprinting2.14607257
13MP0002735_abnormal_chemical_nociception2.13534912
14MP0003787_abnormal_imprinting2.09882884
15MP0009745_abnormal_behavioral_response2.06047743
16MP0002653_abnormal_ependyma_morphology2.05539176
17MP0002734_abnormal_mechanical_nocicepti2.00866629
18MP0002102_abnormal_ear_morphology1.98144987
19MP0006276_abnormal_autonomic_nervous1.96396463
20MP0002064_seizures1.87798155
21MP0003195_calcinosis1.86623702
22MP0005646_abnormal_pituitary_gland1.83562451
23MP0001486_abnormal_startle_reflex1.81344394
24MP0002063_abnormal_learning/memory/cond1.78443731
25MP0005394_taste/olfaction_phenotype1.78335651
26MP0005499_abnormal_olfactory_system1.78335651
27MP0002572_abnormal_emotion/affect_behav1.74259969
28MP0005423_abnormal_somatic_nervous1.72441272
29MP0002638_abnormal_pupillary_reflex1.71863162
30MP0002837_dystrophic_cardiac_calcinosis1.67256564
31MP0003011_delayed_dark_adaptation1.66422372
32MP0001968_abnormal_touch/_nociception1.62763210
33MP0008877_abnormal_DNA_methylation1.62474935
34MP0004142_abnormal_muscle_tone1.62399701
35MP0006072_abnormal_retinal_apoptosis1.60829889
36MP0005645_abnormal_hypothalamus_physiol1.59997619
37MP0002736_abnormal_nociception_after1.55668739
38MP0008789_abnormal_olfactory_epithelium1.54643718
39MP0008995_early_reproductive_senescence1.52450946
40MP0005551_abnormal_eye_electrophysiolog1.52343279
41MP0008058_abnormal_DNA_repair1.50982074
42MP0005084_abnormal_gallbladder_morpholo1.43229502
43MP0005253_abnormal_eye_physiology1.42172003
44MP0001970_abnormal_pain_threshold1.41921229
45MP0000566_synostosis1.38897250
46MP0002067_abnormal_sensory_capabilities1.37742585
47MP0003786_premature_aging1.37288419
48MP0000631_abnormal_neuroendocrine_gland1.35721679
49MP0000955_abnormal_spinal_cord1.30517688
50MP0002733_abnormal_thermal_nociception1.29520093
51MP0002184_abnormal_innervation1.28662738
52MP0004811_abnormal_neuron_physiology1.27990017
53MP0002234_abnormal_pharynx_morphology1.26485022
54MP0006035_abnormal_mitochondrial_morpho1.26419016
55MP0001502_abnormal_circadian_rhythm1.25793843
56MP0001905_abnormal_dopamine_level1.24943061
57MP0002557_abnormal_social/conspecific_i1.23713084
58MP0002882_abnormal_neuron_morphology1.19530298
59MP0009780_abnormal_chondrocyte_physiolo1.15668196
60MP0004147_increased_porphyrin_level1.11638454
61MP0002752_abnormal_somatic_nervous1.09946601
62MP0001188_hyperpigmentation1.07803945
63MP0004924_abnormal_behavior1.05643464
64MP0005386_behavior/neurological_phenoty1.05643464
65MP0004742_abnormal_vestibular_system1.05266048
66MP0002066_abnormal_motor_capabilities/c1.05174946
67MP0003123_paternal_imprinting1.04464752
68MP0001501_abnormal_sleep_pattern1.03804329
69MP0000647_abnormal_sebaceous_gland1.03363632
70MP0002751_abnormal_autonomic_nervous0.99698997
71MP0006036_abnormal_mitochondrial_physio0.99566061
72MP0004133_heterotaxia0.97855295
73MP0000026_abnormal_inner_ear0.96213378
74MP0003119_abnormal_digestive_system0.96068267
75MP0003938_abnormal_ear_development0.95620714
76MP0001299_abnormal_eye_distance/0.95503623
77MP0001986_abnormal_taste_sensitivity0.94377597
78MP0002229_neurodegeneration0.91376375
79MP0002069_abnormal_eating/drinking_beha0.91031794
80MP0005623_abnormal_meninges_morphology0.86358653
81MP0005248_abnormal_Harderian_gland0.85818670
82MP0005451_abnormal_body_composition0.84541697
83MP0003137_abnormal_impulse_conducting0.83052859
84MP0002152_abnormal_brain_morphology0.82007118
85MP0004215_abnormal_myocardial_fiber0.81920125
86MP0002090_abnormal_vision0.81895458
87MP0003221_abnormal_cardiomyocyte_apopto0.81456168
88MP0000049_abnormal_middle_ear0.81314753
89MP0003718_maternal_effect0.78760064
90MP0001346_abnormal_lacrimal_gland0.77250350
91MP0005187_abnormal_penis_morphology0.76733677
92MP0000427_abnormal_hair_cycle0.76122071
93MP0003283_abnormal_digestive_organ0.75658712
94MP0005171_absent_coat_pigmentation0.75393905
95MP0001177_atelectasis0.75037206
96MP0001963_abnormal_hearing_physiology0.72936363
97MP0000372_irregular_coat_pigmentation0.72258107
98MP0005195_abnormal_posterior_eye0.72200752
99MP0002909_abnormal_adrenal_gland0.71635837
100MP0000749_muscle_degeneration0.71148552

Predicted human phenotypes

RankGene SetZ-score
1Polyphagia (HP:0002591)4.08628008
2Split foot (HP:0001839)3.97857910
3Abnormality of glycolysis (HP:0004366)3.40154918
4Acute necrotizing encephalopathy (HP:0006965)3.40005192
5Abnormality of the labia minora (HP:0012880)3.35135631
6Gait imbalance (HP:0002141)3.28930022
7Abnormal mitochondria in muscle tissue (HP:0008316)3.28462653
8Medial flaring of the eyebrow (HP:0010747)3.25519604
9Congenital primary aphakia (HP:0007707)3.09843210
10Myokymia (HP:0002411)3.02503786
11Progressive macrocephaly (HP:0004481)2.92298432
12Nephrogenic diabetes insipidus (HP:0009806)2.91983794
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.87051576
14Decreased activity of mitochondrial respiratory chain (HP:0008972)2.87051576
15Methylmalonic acidemia (HP:0002912)2.85748123
16Increased serum pyruvate (HP:0003542)2.83335956
17Mitochondrial inheritance (HP:0001427)2.81720873
18Upper limb muscle weakness (HP:0003484)2.75538877
19Focal motor seizures (HP:0011153)2.75118179
20Type II lissencephaly (HP:0007260)2.70175508
21Acute encephalopathy (HP:0006846)2.67286161
22Hepatocellular necrosis (HP:0001404)2.66937817
23Abnormal gallbladder physiology (HP:0012438)2.65357166
24Cholecystitis (HP:0001082)2.65357166
25Retinal dysplasia (HP:0007973)2.60638518
26Synostosis involving the elbow (HP:0003938)2.52683087
27Humeroradial synostosis (HP:0003041)2.52683087
28Absent speech (HP:0001344)2.52579074
29Cerebellar dysplasia (HP:0007033)2.49354127
30Genital tract atresia (HP:0001827)2.48028010
31Hypsarrhythmia (HP:0002521)2.47908901
32Amyotrophic lateral sclerosis (HP:0007354)2.45544682
33EEG with generalized epileptiform discharges (HP:0011198)2.44781497
34Febrile seizures (HP:0002373)2.44161717
35Hepatic necrosis (HP:0002605)2.42693047
36Vaginal atresia (HP:0000148)2.42539863
37Epileptiform EEG discharges (HP:0011182)2.42168721
38True hermaphroditism (HP:0010459)2.40878873
39Abnormal eating behavior (HP:0100738)2.39512103
40Abnormality of midbrain morphology (HP:0002418)2.38982135
41Molar tooth sign on MRI (HP:0002419)2.38982135
42Poor suck (HP:0002033)2.38733751
43Shoulder girdle muscle weakness (HP:0003547)2.38483875
44Increased CSF lactate (HP:0002490)2.38408496
45Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.37185773
46Degeneration of the lateral corticospinal tracts (HP:0002314)2.37185773
47Lissencephaly (HP:0001339)2.31583472
48Failure to thrive in infancy (HP:0001531)2.24407973
49Abnormality of the hip-girdle musculature (HP:0001445)2.24107139
50Abnormality of the musculature of the pelvis (HP:0001469)2.24107139
51Atonic seizures (HP:0010819)2.23678769
52Abnormality of the corticospinal tract (HP:0002492)2.23109317
53Hypoplastic pelvis (HP:0008839)2.22297419
54Methylmalonic aciduria (HP:0012120)2.19535484
55Renal cortical cysts (HP:0000803)2.13819289
56Postnatal microcephaly (HP:0005484)2.12346130
57Impaired vibration sensation in the lower limbs (HP:0002166)2.11659137
58Neonatal respiratory distress (HP:0002643)2.10697345
59Abnormal protein glycosylation (HP:0012346)2.09956751
60Abnormal glycosylation (HP:0012345)2.09956751
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09956751
62Abnormal protein N-linked glycosylation (HP:0012347)2.09956751
63Tubulointerstitial nephritis (HP:0001970)2.09156960
64Cerebral edema (HP:0002181)2.06366408
65Esotropia (HP:0000565)2.00114651
66Severe muscular hypotonia (HP:0006829)1.99575329
67Increased corneal curvature (HP:0100692)1.99285542
68Keratoconus (HP:0000563)1.99285542
69Epileptic encephalopathy (HP:0200134)1.98674406
70Muscular hypotonia of the trunk (HP:0008936)1.97604699
71Oligodactyly (hands) (HP:0001180)1.97105040
72Spastic gait (HP:0002064)1.96648180
73Generalized myoclonic seizures (HP:0002123)1.94360825
74Adactyly (HP:0009776)1.94095405
75Scrotal hypoplasia (HP:0000046)1.94007150
76Optic disc pallor (HP:0000543)1.93786771
77Specific learning disability (HP:0001328)1.92844254
78Increased hepatocellular lipid droplets (HP:0006565)1.92557535
79Hand muscle atrophy (HP:0009130)1.91834169
80Broad foot (HP:0001769)1.91101093
81Hypothermia (HP:0002045)1.90016531
82Urinary urgency (HP:0000012)1.89881658
83Type I transferrin isoform profile (HP:0003642)1.89123059
84Generalized tonic-clonic seizures (HP:0002069)1.88930854
85Tongue fasciculations (HP:0001308)1.86054120
86Pancreatic fibrosis (HP:0100732)1.85822314
87Focal seizures (HP:0007359)1.85339809
88Postaxial hand polydactyly (HP:0001162)1.85254127
89Pelvic girdle muscle weakness (HP:0003749)1.84850021
90Decreased testicular size (HP:0008734)1.84830856
91Atrophy/Degeneration involving motor neurons (HP:0007373)1.84778767
92Increased intramyocellular lipid droplets (HP:0012240)1.83863491
93Dialeptic seizures (HP:0011146)1.83176707
94Lactic acidosis (HP:0003128)1.82121414
95Lipid accumulation in hepatocytes (HP:0006561)1.81090652
96Emotional lability (HP:0000712)1.80199080
97Sclerocornea (HP:0000647)1.78885713
98Hypoplasia of the brainstem (HP:0002365)1.78132068
99Aplasia/Hypoplasia of the brainstem (HP:0007362)1.78132068
100Abnormality of the metopic suture (HP:0005556)1.77638448

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.94136301
2MAP2K73.68702288
3CASK3.41752886
4MAP3K43.32470858
5EPHA43.25751825
6MAP4K23.23308003
7BCR2.92136203
8MARK12.57546516
9TESK12.35538343
10ERBB32.32532659
11LIMK12.24022844
12BCKDK2.12305540
13CSNK1G32.02672289
14CSNK1A1L1.97569203
15CSNK1G21.93895828
16NEK11.85879421
17VRK21.79042220
18TESK21.78139859
19TSSK61.77982549
20WNK31.71076818
21CSNK1G11.70006916
22SRPK11.57434305
23MAP3K121.53486949
24EIF2AK11.50848301
25SIK31.48295764
26BUB11.45788538
27VRK11.42614474
28MINK11.38881820
29DYRK21.36619354
30DAPK11.35164765
31MAPK131.29617510
32MUSK1.28139924
33CDK191.27863589
34EPHA31.27630410
35PAK61.20091262
36DAPK21.16223783
37NUAK11.13375128
38MAP2K41.09476236
39MAPK151.08300141
40PAK30.96600687
41CAMKK20.93675480
42GRK50.87427168
43OXSR10.87373288
44PRKCG0.81158402
45UHMK10.77247092
46PLK20.76960757
47PRKCE0.74068688
48PIM20.73180618
49CDK140.71562386
50CDK50.70207767
51PHKG10.68165019
52PHKG20.68165019
53GRK70.67400188
54MAP3K60.66494370
55PLK30.66299989
56STK160.65111473
57CDK180.63692078
58MKNK20.62798255
59PINK10.62531554
60GRK10.62496522
61PBK0.61868764
62NTRK20.61263495
63CAMK2A0.59801352
64FER0.59244434
65PRKD30.56380821
66CAMK2B0.55512873
67NTRK30.55499083
68CCNB10.55002933
69MAP3K50.53669746
70CDK11A0.51374210
71CDK150.51242721
72FGFR20.49993921
73PDK20.49356971
74NME10.48994423
75EIF2AK30.48530448
76PKN10.47198233
77MYLK0.46965189
78ADRBK20.46658571
79CSNK1A10.45754737
80DYRK1A0.44547291
81BRSK10.42487110
82SIK20.42240117
83NEK60.41788117
84TLK10.40617862
85EPHA20.39769079
86PRKACA0.37637700
87MATK0.34837153
88RPS6KA50.34076370
89MKNK10.33875658
90AURKA0.32727649
91CAMK2G0.30830638
92MST1R0.30512298
93ADRBK10.30391266
94PLK10.29334444
95AKT20.28512511
96CDK30.28209026
97CSNK2A10.28052846
98STK390.27810980
99PTK2B0.27687302
100EGFR0.27661517

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.69509494
2Oxidative phosphorylation_Homo sapiens_hsa001903.35735437
3Proteasome_Homo sapiens_hsa030502.92323768
4Parkinsons disease_Homo sapiens_hsa050122.72341117
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.34642045
6Synaptic vesicle cycle_Homo sapiens_hsa047212.23424885
7Nicotine addiction_Homo sapiens_hsa050332.17178140
8RNA polymerase_Homo sapiens_hsa030202.15804036
9Collecting duct acid secretion_Homo sapiens_hsa049662.12841532
10Steroid biosynthesis_Homo sapiens_hsa001001.98861020
11Vibrio cholerae infection_Homo sapiens_hsa051101.98790443
12Huntingtons disease_Homo sapiens_hsa050161.94832731
13Fatty acid elongation_Homo sapiens_hsa000621.91596610
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91556617
15Alzheimers disease_Homo sapiens_hsa050101.87063055
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85922744
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.79194112
18GABAergic synapse_Homo sapiens_hsa047271.75634402
19Phototransduction_Homo sapiens_hsa047441.64031891
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.57098568
21Sulfur metabolism_Homo sapiens_hsa009201.54416634
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53012784
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.52198797
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49643286
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47917437
26Folate biosynthesis_Homo sapiens_hsa007901.47345358
27Regulation of autophagy_Homo sapiens_hsa041401.46444074
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42837367
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38528369
30Dopaminergic synapse_Homo sapiens_hsa047281.38371066
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31364201
32Basal transcription factors_Homo sapiens_hsa030221.29908894
33Propanoate metabolism_Homo sapiens_hsa006401.29503494
34Vitamin B6 metabolism_Homo sapiens_hsa007501.28940450
35Cocaine addiction_Homo sapiens_hsa050301.25450844
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24368957
37Butanoate metabolism_Homo sapiens_hsa006501.24187337
38Cardiac muscle contraction_Homo sapiens_hsa042601.22861193
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21744297
40Amphetamine addiction_Homo sapiens_hsa050311.17094775
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17039304
42Circadian entrainment_Homo sapiens_hsa047131.15673944
43N-Glycan biosynthesis_Homo sapiens_hsa005101.13850241
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13726201
45Morphine addiction_Homo sapiens_hsa050321.11910679
46Circadian rhythm_Homo sapiens_hsa047101.08559285
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00687415
48Glutamatergic synapse_Homo sapiens_hsa047240.99531149
49Spliceosome_Homo sapiens_hsa030400.98811638
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.97239649
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95343384
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90775352
53Oocyte meiosis_Homo sapiens_hsa041140.87854405
54Pyrimidine metabolism_Homo sapiens_hsa002400.87469143
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84786685
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84130550
57RNA transport_Homo sapiens_hsa030130.80162300
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79650280
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.79031083
60Biosynthesis of amino acids_Homo sapiens_hsa012300.78713101
61Insulin secretion_Homo sapiens_hsa049110.77492173
62Taste transduction_Homo sapiens_hsa047420.76536024
63Metabolic pathways_Homo sapiens_hsa011000.75572672
64Base excision repair_Homo sapiens_hsa034100.75338238
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75313185
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72766452
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69261838
68Carbon metabolism_Homo sapiens_hsa012000.69049782
69Sulfur relay system_Homo sapiens_hsa041220.66997126
70Peroxisome_Homo sapiens_hsa041460.63676438
71Purine metabolism_Homo sapiens_hsa002300.63361570
72Selenocompound metabolism_Homo sapiens_hsa004500.60917821
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59654545
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58622091
75Nucleotide excision repair_Homo sapiens_hsa034200.56697768
76Caffeine metabolism_Homo sapiens_hsa002320.53923829
77Olfactory transduction_Homo sapiens_hsa047400.53495493
78Fructose and mannose metabolism_Homo sapiens_hsa000510.52829872
79Alcoholism_Homo sapiens_hsa050340.52618710
80Pyruvate metabolism_Homo sapiens_hsa006200.51729487
81Fanconi anemia pathway_Homo sapiens_hsa034600.51386903
82mRNA surveillance pathway_Homo sapiens_hsa030150.50800557
83RNA degradation_Homo sapiens_hsa030180.50657775
84Fatty acid metabolism_Homo sapiens_hsa012120.50159178
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48714877
86Arginine and proline metabolism_Homo sapiens_hsa003300.46662722
87Salivary secretion_Homo sapiens_hsa049700.44574320
88Hippo signaling pathway_Homo sapiens_hsa043900.44084555
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42870907
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39890832
91Long-term depression_Homo sapiens_hsa047300.37932841
92Axon guidance_Homo sapiens_hsa043600.36878645
93Serotonergic synapse_Homo sapiens_hsa047260.36715799
94Phenylalanine metabolism_Homo sapiens_hsa003600.36410337
95Hedgehog signaling pathway_Homo sapiens_hsa043400.33543327
96Shigellosis_Homo sapiens_hsa051310.32302336
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32023082
98Nitrogen metabolism_Homo sapiens_hsa009100.31327624
99Tight junction_Homo sapiens_hsa045300.27478127
100Cholinergic synapse_Homo sapiens_hsa047250.24706074

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