SYNM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle. Two alternatively spliced variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)6.91491045
2muscle filament sliding (GO:0030049)6.40869417
3actin-myosin filament sliding (GO:0033275)6.40869417
4sarcoplasmic reticulum calcium ion transport (GO:0070296)6.01062112
5cardiac myofibril assembly (GO:0055003)5.80604187
6skeletal muscle contraction (GO:0003009)5.40667461
7actin-mediated cell contraction (GO:0070252)5.38835702
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.28809605
9plasma membrane repair (GO:0001778)5.20379902
10skeletal muscle adaptation (GO:0043501)5.15999231
11cardiac muscle hypertrophy (GO:0003300)4.98986135
12neuronal action potential propagation (GO:0019227)4.77485542
13striated muscle hypertrophy (GO:0014897)4.74028567
14regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.67115101
15actin filament-based movement (GO:0030048)4.23819987
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.23770253
17muscle hypertrophy (GO:0014896)4.23589904
18creatine metabolic process (GO:0006600)4.23315750
19skeletal muscle fiber development (GO:0048741)4.14638867
20regulation of cell communication by electrical coupling (GO:0010649)4.12227463
21glycogen catabolic process (GO:0005980)4.11950496
22cardiac muscle cell development (GO:0055013)3.94120462
23cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.89083438
24negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.87379665
25glucan catabolic process (GO:0009251)3.85977953
26adult heart development (GO:0007512)3.84982798
27response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.79739476
28cardiac cell development (GO:0055006)3.76338927
29striated muscle contraction (GO:0006941)3.71911004
30muscle contraction (GO:0006936)3.71483423
31cardiac muscle adaptation (GO:0014887)3.71345478
32cardiac muscle hypertrophy in response to stress (GO:0014898)3.71345478
33muscle hypertrophy in response to stress (GO:0003299)3.71345478
34carnitine shuttle (GO:0006853)3.70059275
35regulation of the force of heart contraction (GO:0002026)3.69849510
36sarcomere organization (GO:0045214)3.68849765
37muscle tissue morphogenesis (GO:0060415)3.63919565
38NADH metabolic process (GO:0006734)3.59821872
39cardiac muscle tissue morphogenesis (GO:0055008)3.57913155
40regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.53006014
41myotube cell development (GO:0014904)3.52262108
42cellular polysaccharide catabolic process (GO:0044247)3.51778057
43regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.43612289
44regulation of myoblast differentiation (GO:0045661)3.38582821
45negative regulation of potassium ion transmembrane transport (GO:1901380)3.37255094
46skeletal muscle tissue development (GO:0007519)3.36683633
47polysaccharide catabolic process (GO:0000272)3.34693695
48striated muscle cell development (GO:0055002)3.32717781
49muscle system process (GO:0003012)3.30765333
50cellular response to epinephrine stimulus (GO:0071872)3.30157315
51myofibril assembly (GO:0030239)3.29338826
52neurofilament cytoskeleton organization (GO:0060052)3.27826630
53neuromuscular synaptic transmission (GO:0007274)3.27761319
54positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.26556280
55cGMP-mediated signaling (GO:0019934)3.26325676
56cell communication by electrical coupling (GO:0010644)3.26294359
57response to epinephrine (GO:0071871)3.25403839
58regulation of calcium ion transmembrane transporter activity (GO:1901019)3.22520818
59regulation of calcium ion transmembrane transport (GO:1903169)3.22520818
60membrane depolarization during action potential (GO:0086010)3.20356512
61muscle organ development (GO:0007517)3.17290662
62response to inactivity (GO:0014854)3.17147920
63muscle structure development (GO:0061061)3.15609320
64potassium ion import (GO:0010107)3.15283252
65muscle fiber development (GO:0048747)3.14906737
66regulation of cardiac muscle cell contraction (GO:0086004)3.13260468
67ventricular cardiac muscle cell action potential (GO:0086005)3.11897001
68relaxation of cardiac muscle (GO:0055119)3.11043522
69positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.07068002
70pyrimidine ribonucleoside catabolic process (GO:0046133)3.06751232
71cellular potassium ion homeostasis (GO:0030007)3.03855211
72fatty acid transmembrane transport (GO:1902001)3.02921619
73striated muscle atrophy (GO:0014891)3.02007380
74hypotonic response (GO:0006971)3.01358708
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.97841630
76muscle cell development (GO:0055001)2.97213066
77glucan biosynthetic process (GO:0009250)2.97084977
78glycogen biosynthetic process (GO:0005978)2.97084977
79muscle adaptation (GO:0043500)2.96960949
80response to muscle activity (GO:0014850)2.96253048
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.95993697
82negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.95672457
83actomyosin structure organization (GO:0031032)2.94215518
84negative regulation of calcium ion transmembrane transport (GO:1903170)2.87032939
85negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.87032939
86regulation of cardiac muscle contraction (GO:0055117)2.86977952
87cardiac muscle cell action potential (GO:0086001)2.86059381
88potassium ion homeostasis (GO:0055075)2.83672321
89regulation of skeletal muscle fiber development (GO:0048742)2.83226319
90striated muscle adaptation (GO:0014888)2.82349777
91muscle cell fate commitment (GO:0042693)2.81992472
92neuronal action potential (GO:0019228)2.81127955
93regulation of membrane repolarization (GO:0060306)2.78761837
94regulation of heart contraction (GO:0008016)2.77887910
952-oxoglutarate metabolic process (GO:0006103)2.77765618
96regulation of actin filament-based movement (GO:1903115)2.77537686
97muscle cell cellular homeostasis (GO:0046716)2.77394311
98ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.77394112
99glycogen metabolic process (GO:0005977)2.76700804
100carnitine transmembrane transport (GO:1902603)2.74379062
101positive regulation of potassium ion transport (GO:0043268)2.72345164
102cellular glucan metabolic process (GO:0006073)2.71231455
103glucan metabolic process (GO:0044042)2.71231455
104regulation of relaxation of muscle (GO:1901077)2.69371745
105neuromuscular junction development (GO:0007528)2.66463778
106regulation of striated muscle contraction (GO:0006942)2.66304820
107relaxation of muscle (GO:0090075)2.63368244
108negative regulation of protein localization to cell surface (GO:2000009)2.62854803
109regulation of cation channel activity (GO:2001257)2.60186966
110sodium ion export (GO:0071436)2.59927806
111cardiac muscle contraction (GO:0060048)2.57918523
112synaptic vesicle maturation (GO:0016188)2.57742024
113positive regulation of cation channel activity (GO:2001259)2.56754410
114endoplasmic reticulum organization (GO:0007029)2.56663537
115regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.56568028
116regulation of potassium ion transmembrane transporter activity (GO:1901016)2.55357901
117negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.53163056
118regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.52706729
119central nervous system myelination (GO:0022010)2.51338897
120axon ensheathment in central nervous system (GO:0032291)2.51338897
121positive regulation of potassium ion transmembrane transport (GO:1901381)2.51117374
122regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.50971022
123muscle atrophy (GO:0014889)2.50594685
124regulation of potassium ion transmembrane transport (GO:1901379)2.49030263
125amino-acid betaine transport (GO:0015838)2.46862705
126carnitine transport (GO:0015879)2.46862705
127regulation of skeletal muscle cell differentiation (GO:2001014)2.45278845
128regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.44827767
129detection of temperature stimulus (GO:0016048)2.43744353
130regulation of muscle system process (GO:0090257)2.41436191
131establishment of mitochondrion localization (GO:0051654)2.40318751
132regulation of acyl-CoA biosynthetic process (GO:0050812)2.39017367
133activation of protein kinase A activity (GO:0034199)2.38061070
134negative regulation of muscle hypertrophy (GO:0014741)2.37817245
135cell communication involved in cardiac conduction (GO:0086065)2.37520698
136regulation of muscle contraction (GO:0006937)2.35585586
137regulation of synapse structural plasticity (GO:0051823)2.32457359
138regulation of sodium ion transmembrane transport (GO:1902305)2.32064323

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.06415360
2CDX2_19796622_ChIP-Seq_MESCs_Mouse2.39556779
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31967886
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29875627
5ESR1_20079471_ChIP-ChIP_T-47D_Human2.26297933
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.19431277
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.19431277
8AR_21572438_ChIP-Seq_LNCaP_Human2.15667198
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13177535
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11293020
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.10782608
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08658633
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05550943
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93981668
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86861198
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86708847
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.83925774
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.82247665
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.79670949
20DROSHA_22980978_ChIP-Seq_HELA_Human1.76871869
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76095961
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72345954
23ZNF263_19887448_ChIP-Seq_K562_Human1.69455238
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68565266
25GBX2_23144817_ChIP-Seq_PC3_Human1.68098437
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.66692626
27MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.64930794
28EP300_21415370_ChIP-Seq_HL-1_Mouse1.62915910
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.62734681
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.62533276
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.54577284
32PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.51552072
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50313900
34ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49427280
35BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43650825
36CLOCK_20551151_ChIP-Seq_293T_Human1.41831282
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40048600
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35529203
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35304035
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33424917
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31383469
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.30299615
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.29563910
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26277861
45AHR_22903824_ChIP-Seq_MCF-7_Human1.25647825
46ZNF274_21170338_ChIP-Seq_K562_Hela1.23006199
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22842159
48* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18608847
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18096063
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.18048440
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17264734
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.16088276
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15949878
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15834834
55ARNT_22903824_ChIP-Seq_MCF-7_Human1.15439663
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15260551
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14972636
58CTCF_27219007_Chip-Seq_Bcells_Human1.14089872
59WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13309143
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13185365
61VDR_22108803_ChIP-Seq_LS180_Human1.12642200
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11839283
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11839283
64PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.11163428
65KDM2B_26808549_Chip-Seq_K562_Human1.11000127
66SMAD4_21799915_ChIP-Seq_A2780_Human1.09741650
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08422161
68TBX20_22328084_ChIP-Seq_HEART_Mouse1.07904121
69TBX20_22080862_ChIP-Seq_HEART_Mouse1.07904121
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.05365536
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.05350478
72NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04404707
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04320689
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03585700
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03414360
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03041191
77AR_25329375_ChIP-Seq_VCAP_Human1.02961660
78GATA4_21415370_ChIP-Seq_HL-1_Mouse1.02239754
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01972014
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01168694
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.01145409
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00506702
83* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99929767
84REST_21632747_ChIP-Seq_MESCs_Mouse0.99533044
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98575134
86SMAD_19615063_ChIP-ChIP_OVARY_Human0.98567673
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98077715
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97993485
89REST_18959480_ChIP-ChIP_MESCs_Mouse0.97936013
90CBX2_27304074_Chip-Seq_ESCs_Mouse0.97752787
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97301689
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97004793
93* ISL1_27105846_Chip-Seq_CPCs_Mouse0.96586154
94RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96096408
95TP53_23651856_ChIP-Seq_MEFs_Mouse0.95815126
96LXR_22158963_ChIP-Seq_LIVER_Mouse0.95667086
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95543337
98EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95045092
99* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94453147
100* CJUN_26792858_Chip-Seq_BT549_Human0.94399174
101TP53_20018659_ChIP-ChIP_R1E_Mouse0.94262371
102TP53_16413492_ChIP-PET_HCT116_Human0.92741878
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92129571
104RXR_22108803_ChIP-Seq_LS180_Human0.91852738
105BCAT_22108803_ChIP-Seq_LS180_Human0.91378047
106NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90956486
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90587858
108KDM2B_26808549_Chip-Seq_DND41_Human0.90092860
109AR_19668381_ChIP-Seq_PC3_Human0.88920693
110BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88801759
111* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88746824
112TAF15_26573619_Chip-Seq_HEK293_Human0.87400318
113ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87106015
114RING1B_27294783_Chip-Seq_NPCs_Mouse0.86936192
115* SMAD4_21741376_ChIP-Seq_EPCs_Human0.86480115
116FOXA2_19822575_ChIP-Seq_HepG2_Human0.86277967
117MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86251743
118P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86076849
119TP53_18474530_ChIP-ChIP_U2OS_Human0.85238422
120EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85104512
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85045816
122SMAD3_21741376_ChIP-Seq_EPCs_Human0.84998306
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84885732
124TRIM28_21343339_ChIP-Seq_HEK293_Human0.84755041
125CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84291098
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84128099
127YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84057075
128WT1_19549856_ChIP-ChIP_CCG9911_Human0.83725321
129* SMAD3_21741376_ChIP-Seq_HESCs_Human0.83680109
130SOX9_24532713_ChIP-Seq_HFSC_Mouse0.83462117
131TET1_21490601_ChIP-Seq_MESCs_Mouse0.81203241

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio5.87273389
2MP0000751_myopathy4.75338784
3MP0000749_muscle_degeneration4.60972451
4MP0003646_muscle_fatigue3.92773945
5MP0004036_abnormal_muscle_relaxation3.51749333
6MP0000747_muscle_weakness3.48408446
7MP0004270_analgesia3.24174283
8MP0002837_dystrophic_cardiac_calcinosis3.07026920
9MP0002106_abnormal_muscle_physiology2.80475133
10MP0000759_abnormal_skeletal_muscle2.64799653
11MP0005620_abnormal_muscle_contractility2.61868604
12MP0004130_abnormal_muscle_cell2.53999621
13MP0004087_abnormal_muscle_fiber2.46534462
14MP0005369_muscle_phenotype2.43073112
15MP0002269_muscular_atrophy2.38406564
16MP0005670_abnormal_white_adipose2.37391729
17MP0004510_myositis2.37032204
18MP0002735_abnormal_chemical_nociception2.26517210
19MP0004859_abnormal_synaptic_plasticity2.26403783
20MP0000750_abnormal_muscle_regeneration2.19819675
21MP0004858_abnormal_nervous_system2.05519345
22MP0005451_abnormal_body_composition1.99026394
23MP0001968_abnormal_touch/_nociception1.96953644
24MP0002734_abnormal_mechanical_nocicepti1.85544992
25MP0004147_increased_porphyrin_level1.81769968
26MP0004233_abnormal_muscle_weight1.77381490
27MP0002736_abnormal_nociception_after1.73647097
28MP0002108_abnormal_muscle_morphology1.67303085
29MP0002127_abnormal_cardiovascular_syste1.66682733
30MP0005330_cardiomyopathy1.62804436
31MP0002332_abnormal_exercise_endurance1.55021964
32MP0004084_abnormal_cardiac_muscle1.49250751
33MP0004185_abnormal_adipocyte_glucose1.48277001
34MP0004484_altered_response_of1.44327970
35MP0003329_amyloid_beta_deposits1.42790166
36MP0002733_abnormal_thermal_nociception1.40027277
37MP0000733_abnormal_muscle_development1.39141125
38MP0010386_abnormal_urinary_bladder1.35145429
39MP0001299_abnormal_eye_distance/1.31517644
40MP0004215_abnormal_myocardial_fiber1.31366027
41MP0003635_abnormal_synaptic_transmissio1.30796028
42MP0009780_abnormal_chondrocyte_physiolo1.30240877
43MP0000013_abnormal_adipose_tissue1.29592668
44MP0001970_abnormal_pain_threshold1.28811549
45MP0002972_abnormal_cardiac_muscle1.26683149
46MP0003950_abnormal_plasma_membrane1.17577827
47MP0002272_abnormal_nervous_system1.17037970
48MP0001661_extended_life_span1.13753559
49MP0008569_lethality_at_weaning1.12812517
50MP0003880_abnormal_central_pattern1.12725303
51MP0003045_fibrosis1.10844037
52MP0005275_abnormal_skin_tensile1.09637124
53MP0005666_abnormal_adipose_tissue1.09587105
54MP0010368_abnormal_lymphatic_system1.03317607
55MP0000920_abnormal_myelination1.03141761
56MP0003879_abnormal_hair_cell1.02734515
57MP0005266_abnormal_metabolism1.01797593
58MP0009046_muscle_twitch1.00099165
59MP0002067_abnormal_sensory_capabilities0.98573547
60MP0006276_abnormal_autonomic_nervous0.97167136
61MP0001440_abnormal_grooming_behavior0.97027212
62MP0003828_pulmonary_edema0.95817266
63MP0009745_abnormal_behavioral_response0.91798125
64MP0005623_abnormal_meninges_morphology0.91520203
65MP0002064_seizures0.91250857
66MP0000534_abnormal_ureter_morphology0.90337153
67MP0005375_adipose_tissue_phenotype0.90234774
68MP0000955_abnormal_spinal_cord0.89604993
69MP0003633_abnormal_nervous_system0.87234412
70MP0002063_abnormal_learning/memory/cond0.86716880
71MP0001664_abnormal_digestion0.85492563
72MP0002184_abnormal_innervation0.85114615
73MP0003137_abnormal_impulse_conducting0.85012037
74MP0010234_abnormal_vibrissa_follicle0.84515203
75MP0004134_abnormal_chest_morphology0.82675733
76MP0003705_abnormal_hypodermis_morpholog0.82468402
77MP0000462_abnormal_digestive_system0.82394037
78MP0001486_abnormal_startle_reflex0.81499175
79MP0004043_abnormal_pH_regulation0.81307098
80MP0004272_abnormal_basement_membrane0.80764567
81MP0000516_abnormal_urinary_system0.78913937
82MP0005367_renal/urinary_system_phenotyp0.78913937
83MP0009250_abnormal_appendicular_skeleto0.76977403
84MP0000266_abnormal_heart_morphology0.76241172
85MP0010630_abnormal_cardiac_muscle0.74727172
86MP0005423_abnormal_somatic_nervous0.74248035
87MP0004085_abnormal_heartbeat0.74205860
88MP0000762_abnormal_tongue_morphology0.73775885
89MP0003221_abnormal_cardiomyocyte_apopto0.73574909
90MP0006036_abnormal_mitochondrial_physio0.73200664
91MP0003656_abnormal_erythrocyte_physiolo0.70823619
92MP0005165_increased_susceptibility_to0.70731458
93MP0002909_abnormal_adrenal_gland0.70618349
94MP0000230_abnormal_systemic_arterial0.70601109
95MP0002066_abnormal_motor_capabilities/c0.70486392
96MP0001544_abnormal_cardiovascular_syste0.69058739
97MP0005385_cardiovascular_system_phenoty0.69058739
98MP0002971_abnormal_brown_adipose0.68969844
99MP0004811_abnormal_neuron_physiology0.68504856
100MP0005409_darkened_coat_color0.68021402
101MP0005167_abnormal_blood-brain_barrier0.66985177
102MP0000003_abnormal_adipose_tissue0.66154342
103MP0008004_abnormal_stomach_pH0.66141511
104MP0003634_abnormal_glial_cell0.66121026
105MP0003631_nervous_system_phenotype0.66094206
106MP0006138_congestive_heart_failure0.65142534
107MP0000538_abnormal_urinary_bladder0.64498189
108MP0001270_distended_abdomen0.64371128
109MP0002822_catalepsy0.64362492
110MP0000778_abnormal_nervous_system0.64063382
111MP0002128_abnormal_blood_circulation0.62704499
112MP0002882_abnormal_neuron_morphology0.62610574
113MP0001984_abnormal_olfaction0.61838961
114MP0001879_abnormal_lymphatic_vessel0.61306263
115MP0003279_aneurysm0.61061717
116MP0001958_emphysema0.60528159
117MP0005595_abnormal_vascular_smooth0.60423094
118MP0002229_neurodegeneration0.59740106
119MP0008775_abnormal_heart_ventricle0.58649142
120MP0002638_abnormal_pupillary_reflex0.58407642
121MP0000767_abnormal_smooth_muscle0.57599073
122MP0002572_abnormal_emotion/affect_behav0.56833507
123MP0008438_abnormal_cutaneous_collagen0.55242610
124MP0001502_abnormal_circadian_rhythm0.51974335
125MP0005503_abnormal_tendon_morphology0.51886439
126MP0005171_absent_coat_pigmentation0.48012077
127MP0005166_decreased_susceptibility_to0.46431845
128MP0003091_abnormal_cell_migration0.45854959
129MP0002896_abnormal_bone_mineralization0.44356335
130MP0009115_abnormal_fat_cell0.44134229
131MP0005187_abnormal_penis_morphology0.44122679
132MP0002078_abnormal_glucose_homeostasis0.42954710
133MP0000343_altered_response_to0.41653795
134MP0003806_abnormal_nucleotide_metabolis0.39927661
135MP0003566_abnormal_cell_adhesion0.37943876
136MP0003690_abnormal_glial_cell0.36840850
137MP0005334_abnormal_fat_pad0.36698366
138MP0001501_abnormal_sleep_pattern0.36362866
139MP0003948_abnormal_gas_homeostasis0.36062836

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.63347921
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.35054266
3Exercise-induced myalgia (HP:0003738)7.01546650
4Nemaline bodies (HP:0003798)6.95143067
5Distal arthrogryposis (HP:0005684)6.50554288
6Exercise-induced muscle cramps (HP:0003710)6.12891347
7Type 1 muscle fiber predominance (HP:0003803)6.09291448
8Muscle hypertrophy of the lower extremities (HP:0008968)5.57569375
9Myopathic facies (HP:0002058)5.39144707
10Hyporeflexia of lower limbs (HP:0002600)5.34211914
11Round ear (HP:0100830)5.31998525
12Difficulty running (HP:0009046)5.14547874
13Calf muscle hypertrophy (HP:0008981)4.89440387
14Muscle fiber splitting (HP:0003555)4.87533024
15Centrally nucleated skeletal muscle fibers (HP:0003687)4.59583999
16Ulnar deviation of the wrist (HP:0003049)4.59121661
17Absent phalangeal crease (HP:0006109)4.37093547
18Muscle stiffness (HP:0003552)4.33641656
19Myotonia (HP:0002486)4.27970936
20Calcaneovalgus deformity (HP:0001848)4.04117671
21EMG: myopathic abnormalities (HP:0003458)3.85440096
22Myoglobinuria (HP:0002913)3.82033788
23Deformed tarsal bones (HP:0008119)3.75367886
24Increased connective tissue (HP:0009025)3.74972907
25Abnormal finger flexion creases (HP:0006143)3.73490455
26Abnormality of the calf musculature (HP:0001430)3.59603280
27Abnormality of skeletal muscle fiber size (HP:0012084)3.54495770
28Increased variability in muscle fiber diameter (HP:0003557)3.51965870
29Ventricular tachycardia (HP:0004756)3.40021170
30Dilated cardiomyopathy (HP:0001644)3.24020910
31Facial diplegia (HP:0001349)3.23673189
32Lipoatrophy (HP:0100578)3.20561584
33Right ventricular cardiomyopathy (HP:0011663)2.99365939
34Sudden death (HP:0001699)2.99086708
35Neck muscle weakness (HP:0000467)2.98033250
36Heart block (HP:0012722)2.94135409
37Difficulty climbing stairs (HP:0003551)2.86015717
38Abnormal atrioventricular conduction (HP:0005150)2.84843267
39Rhabdomyolysis (HP:0003201)2.80464987
40Scapular winging (HP:0003691)2.75047908
41Atrial fibrillation (HP:0005110)2.73835511
42Papilledema (HP:0001085)2.73150857
43Areflexia of lower limbs (HP:0002522)2.72499743
44Termporal pattern (HP:0011008)2.71009385
45Insidious onset (HP:0003587)2.71009385
46Rimmed vacuoles (HP:0003805)2.70170472
47Generalized muscle weakness (HP:0003324)2.68037255
48Foot dorsiflexor weakness (HP:0009027)2.60450610
49Ventricular arrhythmia (HP:0004308)2.58477629
50Hyperkalemia (HP:0002153)2.57624405
51Ulnar claw (HP:0001178)2.57483419
52Frequent falls (HP:0002359)2.56091856
53Syncope (HP:0001279)2.53366014
54Abnormality of the calcaneus (HP:0008364)2.49051057
55Primary atrial arrhythmia (HP:0001692)2.45780445
56Subaortic stenosis (HP:0001682)2.41248146
57Abnormality of the left ventricular outflow tract (HP:0011103)2.41248146
58Abnormality of the foot musculature (HP:0001436)2.38311209
59Aortic aneurysm (HP:0004942)2.36111436
60Supraventricular tachycardia (HP:0004755)2.35384365
61Increased density of long bones (HP:0006392)2.35168202
62Ankle clonus (HP:0011448)2.32187673
63Supraventricular arrhythmia (HP:0005115)2.31950696
64Asymmetric septal hypertrophy (HP:0001670)2.29608296
65EMG: neuropathic changes (HP:0003445)2.28777889
66Myokymia (HP:0002411)2.26882909
67Abnormality of the shoulder girdle musculature (HP:0001435)2.24883958
68Ventricular fibrillation (HP:0001663)2.24823174
69Atrioventricular block (HP:0001678)2.23281971
70Shoulder girdle muscle weakness (HP:0003547)2.22840176
71Weak cry (HP:0001612)2.21202615
72Distal lower limb muscle weakness (HP:0009053)2.19878998
73Stridor (HP:0010307)2.14178034
74Ulnar deviation of finger (HP:0009465)2.13970303
75Urinary urgency (HP:0000012)2.13622021
76Muscular dystrophy (HP:0003560)2.10679224
77Abnormality of the hip-girdle musculature (HP:0001445)2.09237709
78Abnormality of the musculature of the pelvis (HP:0001469)2.09237709
79Hip contracture (HP:0003273)2.08728613
80Achilles tendon contracture (HP:0001771)2.07081089
81Malignant hyperthermia (HP:0002047)2.06063764
82Proximal amyotrophy (HP:0007126)2.05008666
83Steppage gait (HP:0003376)2.04242821
84Nuclear cataract (HP:0100018)2.04204856
85Gowers sign (HP:0003391)2.03003780
86Mildly elevated creatine phosphokinase (HP:0008180)2.02438429
87Prolonged QT interval (HP:0001657)2.01321671
88Spinal rigidity (HP:0003306)2.01103506
89Focal motor seizures (HP:0011153)1.99770824
90Pelvic girdle muscle weakness (HP:0003749)1.99556417
91Waddling gait (HP:0002515)1.99322393
92Slender build (HP:0001533)1.97879331
93Action tremor (HP:0002345)1.95794933
94Respiratory insufficiency due to muscle weakness (HP:0002747)1.93694698
95Pheochromocytoma (HP:0002666)1.89160433
96Limb-girdle muscle atrophy (HP:0003797)1.88750158
97Limb-girdle muscle weakness (HP:0003325)1.85069334
98Abnormality of the Achilles tendon (HP:0005109)1.80309698
99Hypoplastic ischia (HP:0003175)1.78946382
100Paralysis (HP:0003470)1.78405555
101Abnormality of the ischium (HP:0003174)1.78280643
102Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.75966574
103Degeneration of the lateral corticospinal tracts (HP:0002314)1.75966574
104Supranuclear gaze palsy (HP:0000605)1.75541350
105Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.74442299
106Tarsal synostosis (HP:0008368)1.73982415
107Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70447399
108Abnormality of the corticospinal tract (HP:0002492)1.70062125
109Fetal akinesia sequence (HP:0001989)1.69813902
110Abnormal EKG (HP:0003115)1.69455246
111Ragged-red muscle fibers (HP:0003200)1.69019535
112Fatigable weakness (HP:0003473)1.68134004
113Abnormality of the neuromuscular junction (HP:0003398)1.68134004
114Aortic dissection (HP:0002647)1.68088304
115Dysmetric saccades (HP:0000641)1.67975735
116Limited hip movement (HP:0008800)1.67637111
117Distal lower limb amyotrophy (HP:0008944)1.66040569
118Rapidly progressive (HP:0003678)1.65845360
119Nonprogressive disorder (HP:0003680)1.65448366
120Bundle branch block (HP:0011710)1.64903757
121Onion bulb formation (HP:0003383)1.64510573
122Lower limb amyotrophy (HP:0007210)1.64223347
123Bulbar palsy (HP:0001283)1.63938741
124Diaphragmatic weakness (HP:0009113)1.62739352
125Lower limb muscle weakness (HP:0007340)1.60450613
126Congenital hip dislocation (HP:0001374)1.59738174
127Palpitations (HP:0001962)1.54586860
128Obstructive sleep apnea (HP:0002870)1.54143752
129Resting tremor (HP:0002322)1.52154526
130Cerebral aneurysm (HP:0004944)1.49664319
131Progressive muscle weakness (HP:0003323)1.44942609
132Difficulty walking (HP:0002355)1.43850697
133Left ventricular hypertrophy (HP:0001712)1.39963792
134Metatarsus adductus (HP:0001840)1.38392971

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.16115576
2PHKG24.78648917
3PHKG14.78648917
4OBSCN4.76769359
5PIK3CG2.70709762
6NME12.59355075
7MYLK2.50845778
8DMPK2.47372739
9LMTK22.29531738
10STK392.07961876
11KSR21.89934940
12MAP2K41.82163519
13MAP3K91.73010941
14NTRK31.64297612
15NTRK11.63930546
16PIK3CA1.54597952
17EEF2K1.51490168
18MINK11.50456212
19PINK11.47263283
20LIMK11.45329345
21MAP3K21.42741055
22MAP3K71.42563575
23PDK41.33890306
24PDK31.33890306
25LATS21.33086129
26MAP2K31.23613327
27MAPKAPK31.19176263
28PDK21.15085433
29PAK61.10808287
30TRIB31.09682105
31MAPK121.08869327
32EPHB11.05549996
33NEK11.02833563
34WNK11.02101514
35CAMK2G1.01646161
36MAP3K41.01319878
37RET1.00582652
38PNCK0.99049002
39LATS10.97871720
40MAP3K130.97817100
41MAP2K60.96686178
42FER0.96482776
43MOS0.91896392
44AKT30.90628926
45MARK10.88587185
46SGK20.88185720
47MARK30.86435702
48ICK0.85960264
49MAPKAPK50.84699506
50SGK30.83133821
51RIPK10.82800101
52PAK20.80197968
53OXSR10.74522269
54CAMK40.74196498
55DDR20.71815930
56ROCK10.71505701
57NEK90.71110222
58ROCK20.69453418
59MAP2K10.69245788
60MARK20.69152699
61TIE10.67329224
62WNK40.66527703
63FGFR20.66482324
64MAPK40.65061853
65PRKD30.64465316
66MAPK70.63658681
67GRK50.63313801
68CAMK1G0.62812395
69MAP3K10.62076089
70EPHA30.61387209
71RPS6KA20.61241027
72MTOR0.60476426
73PAK30.59795223
74PTK2B0.58098123
75SGK2230.56654940
76SGK4940.56654940
77PDGFRA0.55505540
78CDK50.55412454
79PKN10.51906566
80PRKAA20.51695515
81MAP3K120.51600962
82PDPK10.51573857
83AKT20.51212155
84STK38L0.50986304
85PRKAA10.50756901
86PRKACB0.50498323
87CAMK2D0.50489819
88DAPK20.50057907
89BCKDK0.49899191
90CDC42BPA0.48475452
91TRPM70.48281092
92MUSK0.48172933
93MAPK130.47815515
94FRK0.44854939
95CCNB10.44367725
96SGK10.43816483
97PRKD10.43729280
98TAOK10.42810769
99STK380.42196847
100CAMK2A0.41228889
101MAPK100.40796295
102MAPK150.40512577
103CAMK2B0.39770472
104MAP2K20.37843898
105MET0.37389448
106PDK10.37315947
107ILK0.36312399
108PRKG10.36081022
109RPS6KB10.35159566
110EPHA40.32692179
111RPS6KA30.32601965
112GSK3A0.32532645
113NLK0.31814390
114SIK10.31493495
115MAPK110.30896317
116MAP3K60.30857396
117MAP2K70.30454540
118PRKCH0.30335297
119ARAF0.29758966
120TNK20.29375993
121PRPF4B0.28792133
122PTK20.28547105
123TGFBR20.28152436
124RPS6KC10.28073037
125RPS6KL10.28073037
126CAMK10.27659759
127PRKACA0.27140170
128TYRO30.26518536
129RPS6KA10.25432327
130UHMK10.24957037
131PKN20.20647840

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.46464629
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.31774216
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.20353381
4Dilated cardiomyopathy_Homo sapiens_hsa054142.15016474
5Cardiac muscle contraction_Homo sapiens_hsa042602.14669413
6Gastric acid secretion_Homo sapiens_hsa049712.06137930
7Oxytocin signaling pathway_Homo sapiens_hsa049212.03806102
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.92189035
9Vascular smooth muscle contraction_Homo sapiens_hsa042701.89827042
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70769351
11Calcium signaling pathway_Homo sapiens_hsa040201.62554597
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56125906
13Renin secretion_Homo sapiens_hsa049241.55060708
14Salivary secretion_Homo sapiens_hsa049701.45990449
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45128832
16cGMP-PKG signaling pathway_Homo sapiens_hsa040221.43304344
17Insulin signaling pathway_Homo sapiens_hsa049101.42090722
18Tight junction_Homo sapiens_hsa045301.39715221
19GnRH signaling pathway_Homo sapiens_hsa049121.38946337
20Circadian entrainment_Homo sapiens_hsa047131.38330312
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37777060
22Arginine biosynthesis_Homo sapiens_hsa002201.37623818
23Arginine and proline metabolism_Homo sapiens_hsa003301.33269335
24Glucagon signaling pathway_Homo sapiens_hsa049221.32781339
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32479568
26Phenylalanine metabolism_Homo sapiens_hsa003601.32190812
27Olfactory transduction_Homo sapiens_hsa047401.31525453
28Long-term potentiation_Homo sapiens_hsa047201.31396557
29Dorso-ventral axis formation_Homo sapiens_hsa043201.28984067
30Insulin secretion_Homo sapiens_hsa049111.28321811
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.21168914
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21149186
33PPAR signaling pathway_Homo sapiens_hsa033201.19181602
34Synaptic vesicle cycle_Homo sapiens_hsa047211.17713758
35Cholinergic synapse_Homo sapiens_hsa047251.17109776
36Focal adhesion_Homo sapiens_hsa045101.13203365
37GABAergic synapse_Homo sapiens_hsa047271.13061117
38Carbon metabolism_Homo sapiens_hsa012001.12252386
39Long-term depression_Homo sapiens_hsa047301.11449313
40Insulin resistance_Homo sapiens_hsa049311.10756320
41Nitrogen metabolism_Homo sapiens_hsa009101.06897980
42Dopaminergic synapse_Homo sapiens_hsa047281.06166706
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05091618
44Fatty acid degradation_Homo sapiens_hsa000711.01821672
45Glutamatergic synapse_Homo sapiens_hsa047241.01565121
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01398789
47Starch and sucrose metabolism_Homo sapiens_hsa005001.00240721
48Gap junction_Homo sapiens_hsa045400.99826833
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.98339688
50Circadian rhythm_Homo sapiens_hsa047100.97490704
51AMPK signaling pathway_Homo sapiens_hsa041520.96917382
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96115758
53VEGF signaling pathway_Homo sapiens_hsa043700.94636989
54Propanoate metabolism_Homo sapiens_hsa006400.92616834
55Alzheimers disease_Homo sapiens_hsa050100.90907583
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90486497
57Melanogenesis_Homo sapiens_hsa049160.87333563
58Amphetamine addiction_Homo sapiens_hsa050310.84877032
59Fructose and mannose metabolism_Homo sapiens_hsa000510.84607633
60cAMP signaling pathway_Homo sapiens_hsa040240.84015036
61Serotonergic synapse_Homo sapiens_hsa047260.83339677
62Fatty acid biosynthesis_Homo sapiens_hsa000610.83173427
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82501784
64Pancreatic secretion_Homo sapiens_hsa049720.82361842
65Taste transduction_Homo sapiens_hsa047420.81892007
66Pentose phosphate pathway_Homo sapiens_hsa000300.81889800
67beta-Alanine metabolism_Homo sapiens_hsa004100.81342122
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80079996
69Glioma_Homo sapiens_hsa052140.79862105
70Estrogen signaling pathway_Homo sapiens_hsa049150.78572244
71Morphine addiction_Homo sapiens_hsa050320.78213395
72ErbB signaling pathway_Homo sapiens_hsa040120.75723258
73Type II diabetes mellitus_Homo sapiens_hsa049300.74718149
74Axon guidance_Homo sapiens_hsa043600.74691014
75ECM-receptor interaction_Homo sapiens_hsa045120.73751479
76MAPK signaling pathway_Homo sapiens_hsa040100.72429575
77Renal cell carcinoma_Homo sapiens_hsa052110.71907429
78Platelet activation_Homo sapiens_hsa046110.69219082
79Histidine metabolism_Homo sapiens_hsa003400.68941108
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.68564161
81Bile secretion_Homo sapiens_hsa049760.67027308
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66862826
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66793083
84Ovarian steroidogenesis_Homo sapiens_hsa049130.65391894
85Sulfur metabolism_Homo sapiens_hsa009200.65231552
86Parkinsons disease_Homo sapiens_hsa050120.65176568
87Amoebiasis_Homo sapiens_hsa051460.64143700
88FoxO signaling pathway_Homo sapiens_hsa040680.63922973
89mTOR signaling pathway_Homo sapiens_hsa041500.62242561
90Nicotine addiction_Homo sapiens_hsa050330.61623826
91Pyruvate metabolism_Homo sapiens_hsa006200.59282127
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58184675
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57595482
94Oxidative phosphorylation_Homo sapiens_hsa001900.57460954
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.56947328
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56540705
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56053726
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.55678558
99Fatty acid elongation_Homo sapiens_hsa000620.54843258
100Choline metabolism in cancer_Homo sapiens_hsa052310.54277466
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.53547836
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52666757
103Proteoglycans in cancer_Homo sapiens_hsa052050.51784064
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51472630
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51261327
106Endocytosis_Homo sapiens_hsa041440.51233666
107Fatty acid metabolism_Homo sapiens_hsa012120.48571416
108Rap1 signaling pathway_Homo sapiens_hsa040150.48413584
109Ras signaling pathway_Homo sapiens_hsa040140.48101922
110Adherens junction_Homo sapiens_hsa045200.47787826
111Thyroid hormone synthesis_Homo sapiens_hsa049180.46870819
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46476578
113Lysine degradation_Homo sapiens_hsa003100.46052405
114Endometrial cancer_Homo sapiens_hsa052130.45350525
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45321547
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45207380
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44819660
118Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43120310
119Tyrosine metabolism_Homo sapiens_hsa003500.39766065
120Biosynthesis of amino acids_Homo sapiens_hsa012300.38198482
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37204971
122Cocaine addiction_Homo sapiens_hsa050300.35318947
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34105188

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