SYNGAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Allelic variants of this gene are associated with intellectual disability and autism spectrum disorder. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.48439263
2synaptic vesicle maturation (GO:0016188)6.47507683
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.42291644
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.16837799
5vocalization behavior (GO:0071625)5.84067517
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.65393161
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.61685550
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.37113672
9regulation of glutamate receptor signaling pathway (GO:1900449)5.27105196
10synaptic vesicle exocytosis (GO:0016079)5.25652882
11glutamate secretion (GO:0014047)5.23970790
12exploration behavior (GO:0035640)4.93723542
13protein localization to synapse (GO:0035418)4.93659771
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.92897095
15regulation of synaptic vesicle exocytosis (GO:2000300)4.88000737
16dendritic spine morphogenesis (GO:0060997)4.83940196
17layer formation in cerebral cortex (GO:0021819)4.80465372
18regulation of synapse structural plasticity (GO:0051823)4.68417684
19* regulation of neuronal synaptic plasticity (GO:0048168)4.65669648
20* regulation of long-term neuronal synaptic plasticity (GO:0048169)4.49647472
21synaptic transmission, glutamatergic (GO:0035249)4.38327615
22neuron cell-cell adhesion (GO:0007158)4.37291664
23regulation of synaptic vesicle transport (GO:1902803)4.33454415
24neurotransmitter secretion (GO:0007269)4.29839632
25neurotransmitter-gated ion channel clustering (GO:0072578)4.26283705
26cerebellar granule cell differentiation (GO:0021707)4.19759741
27glutamate receptor signaling pathway (GO:0007215)4.17283328
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.10795868
29long-term memory (GO:0007616)4.07944181
30positive regulation of membrane potential (GO:0045838)4.07500286
31regulation of excitatory postsynaptic membrane potential (GO:0060079)4.00764515
32neuronal action potential propagation (GO:0019227)4.00746063
33regulation of dendritic spine morphogenesis (GO:0061001)4.00013857
34neuron-neuron synaptic transmission (GO:0007270)3.92252951
35proline transport (GO:0015824)3.89971247
36positive regulation of synapse maturation (GO:0090129)3.80599382
37gamma-aminobutyric acid transport (GO:0015812)3.80154717
38regulation of postsynaptic membrane potential (GO:0060078)3.77907708
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.77526087
40planar cell polarity pathway involved in neural tube closure (GO:0090179)3.75912942
41neuromuscular process controlling balance (GO:0050885)3.74530908
42* regulation of synaptic plasticity (GO:0048167)3.71036777
43cytoskeletal anchoring at plasma membrane (GO:0007016)3.69594593
44auditory behavior (GO:0031223)3.66053003
45cellular potassium ion homeostasis (GO:0030007)3.65290961
46sodium ion export (GO:0071436)3.60881886
47neuron recognition (GO:0008038)3.60431822
48G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.58988280
49positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.57713514
50dendritic spine organization (GO:0097061)3.57098147
51postsynaptic membrane organization (GO:0001941)3.50473436
52activation of protein kinase A activity (GO:0034199)3.49968680
53dendrite morphogenesis (GO:0048813)3.48436281
54positive regulation of synaptic transmission, GABAergic (GO:0032230)3.46672627
55negative regulation of erythrocyte differentiation (GO:0045647)3.45885024
56regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.45207837
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.44736903
58positive regulation of neurotransmitter secretion (GO:0001956)3.41964284
59axonal fasciculation (GO:0007413)3.41370886
60positive regulation of dendritic spine development (GO:0060999)3.41216673
61regulation of NFAT protein import into nucleus (GO:0051532)3.39424981
62neurotransmitter transport (GO:0006836)3.37668741
63transmission of nerve impulse (GO:0019226)3.36371366
64regulation of dendritic spine development (GO:0060998)3.35530525
65response to auditory stimulus (GO:0010996)3.35520197
66long-term synaptic potentiation (GO:0060291)3.34639842
67regulation of neurotransmitter secretion (GO:0046928)3.33867250
68innervation (GO:0060384)3.33389447
69synaptic vesicle endocytosis (GO:0048488)3.33316908
70positive regulation of dendritic spine morphogenesis (GO:0061003)3.32290422
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.29615238
72cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.28262563
73neuronal ion channel clustering (GO:0045161)3.27998977
74cell communication by electrical coupling (GO:0010644)3.26951718
75chemosensory behavior (GO:0007635)3.24952365
76positive regulation of neurotransmitter transport (GO:0051590)3.24785409
77prepulse inhibition (GO:0060134)3.22197606
78regulation of ARF protein signal transduction (GO:0032012)3.20680044
79regulation of vesicle fusion (GO:0031338)3.18851476
80behavioral defense response (GO:0002209)3.18327020
81behavioral fear response (GO:0001662)3.18327020
82membrane depolarization (GO:0051899)3.15736950
83regulation of neurotransmitter levels (GO:0001505)3.15468560
84amino acid import (GO:0043090)3.11364813
85cerebellar Purkinje cell differentiation (GO:0021702)3.09944230
86regulation of neurotransmitter transport (GO:0051588)3.07355481
87glycine transport (GO:0015816)3.04982552
88regulation of ARF GTPase activity (GO:0032312)3.04655396
89social behavior (GO:0035176)3.03966127
90intraspecies interaction between organisms (GO:0051703)3.03966127
91cell migration in hindbrain (GO:0021535)3.03785470
92* learning (GO:0007612)3.03371570
93membrane hyperpolarization (GO:0060081)3.02941121
94neuromuscular process (GO:0050905)3.02773333
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.02714460
96L-amino acid import (GO:0043092)3.02156694
97central nervous system projection neuron axonogenesis (GO:0021952)3.01365363
98membrane depolarization during action potential (GO:0086010)3.01175270
99positive regulation of synaptic transmission (GO:0050806)2.99380831
100regulation of female receptivity (GO:0045924)2.98331397
101fear response (GO:0042596)2.95295805
102* regulation of synaptic transmission (GO:0050804)2.93677339
103synapse assembly (GO:0007416)2.92528751
104vesicle transport along microtubule (GO:0047496)2.92023533
105gamma-aminobutyric acid signaling pathway (GO:0007214)2.91096002
106response to histamine (GO:0034776)2.88351868
107negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.85938884
108regulation of synapse maturation (GO:0090128)2.85830101
109positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.85282062
110negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.80152198
111histone H3-K36 demethylation (GO:0070544)2.78185580
112semaphorin-plexin signaling pathway (GO:0071526)2.76938828
113cell-cell junction maintenance (GO:0045217)2.75811762
114protein-DNA complex disassembly (GO:0032986)2.74569929
115nucleosome disassembly (GO:0006337)2.74569929
116negative regulation of histone methylation (GO:0031061)2.71740869
117regulation of histone H3-K27 methylation (GO:0061085)2.69733754
118convergent extension (GO:0060026)2.69503887
119cell differentiation in hindbrain (GO:0021533)2.69424839
120glucocorticoid receptor signaling pathway (GO:0042921)2.68922102
121adherens junction assembly (GO:0034333)2.63937109
122negative regulation of dendrite morphogenesis (GO:0050774)2.54266053
123dopamine receptor signaling pathway (GO:0007212)2.50035731
124neural tube development (GO:0021915)2.49019524
125positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.48000948
126presynaptic membrane assembly (GO:0097105)2.47721906
127positive regulation of Rap GTPase activity (GO:0032854)2.46937432
128peptidyl-tyrosine autophosphorylation (GO:0038083)2.46671988
129histone H3-K9 demethylation (GO:0033169)2.46316323
130positive regulation of gene expression, epigenetic (GO:0045815)2.45936113
131generation of neurons (GO:0048699)2.44767768
132pre-miRNA processing (GO:0031054)2.42136959
133establishment of nucleus localization (GO:0040023)2.40900770
134histone H4 deacetylation (GO:0070933)2.40449396
135positive regulation of dendrite development (GO:1900006)2.39380889
136positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.39102182
137intracellular estrogen receptor signaling pathway (GO:0030520)2.38804821
138histone lysine demethylation (GO:0070076)2.38217868
139signal complex assembly (GO:0007172)2.37340331
140positive regulation of dendrite morphogenesis (GO:0050775)2.37326815
141mannose metabolic process (GO:0006013)2.36760723
142cell-substrate adherens junction assembly (GO:0007045)2.36706103
143focal adhesion assembly (GO:0048041)2.36706103
144camera-type eye morphogenesis (GO:0048593)2.36243927
145protein targeting to plasma membrane (GO:0072661)2.33016200
146regulation of dendrite morphogenesis (GO:0048814)2.31872943

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.20894012
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10967845
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08014407
4GBX2_23144817_ChIP-Seq_PC3_Human3.03772837
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97791786
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.86328283
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.83532838
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79372981
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79372981
10DROSHA_22980978_ChIP-Seq_HELA_Human2.75310619
11REST_21632747_ChIP-Seq_MESCs_Mouse2.71791424
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68541356
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57039610
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.54927826
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53354726
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51697971
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49810856
18* KDM2B_26808549_Chip-Seq_DND41_Human2.44332173
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43810546
20LXR_22292898_ChIP-Seq_THP-1_Human2.40908505
21* MYC_22102868_ChIP-Seq_BL_Human2.34123410
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33673577
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.32227898
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.31442839
25TCF7_22412390_ChIP-Seq_EML_Mouse2.30792634
26* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.30649699
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.27777199
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.24636055
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.24364409
30REST_18959480_ChIP-ChIP_MESCs_Mouse2.19100978
31IKZF1_21737484_ChIP-ChIP_HCT116_Human2.16505288
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15395621
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.14808446
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.08875306
35STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07354860
36KDM2B_26808549_Chip-Seq_JURKAT_Human1.99456456
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91901366
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91136324
39AR_21572438_ChIP-Seq_LNCaP_Human1.85095153
40VDR_21846776_ChIP-Seq_THP-1_Human1.84562007
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.83935917
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81383844
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.78022342
44* ELK3_25401928_ChIP-Seq_HUVEC_Human1.70324933
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.69722022
46CREB1_26743006_Chip-Seq_LNCaP_Human1.59446588
47SMC4_20622854_ChIP-Seq_HELA_Human1.58356078
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53074958
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51141888
50RACK7_27058665_Chip-Seq_MCF-7_Human1.47693122
51RING1B_27294783_Chip-Seq_ESCs_Mouse1.46716128
52P68_20966046_ChIP-Seq_HELA_Human1.45969100
53SMAD4_21799915_ChIP-Seq_A2780_Human1.44059285
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43212982
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42884485
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39820670
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38884839
58KDM2B_26808549_Chip-Seq_K562_Human1.37187491
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36896063
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36804252
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34619098
62UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33864623
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.32269702
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31927382
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31699552
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30388030
67ZNF274_21170338_ChIP-Seq_K562_Hela1.29735265
68RING1B_27294783_Chip-Seq_NPCs_Mouse1.28753444
69CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27800956
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.26015439
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25809315
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.25236686
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25067784
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24132588
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23436800
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23208246
77* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23162444
78* AR_19668381_ChIP-Seq_PC3_Human1.22991130
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22763108
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.22646793
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22551177
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16123186
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.15388734
84MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14495750
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13955062
86RUNX1_27514584_Chip-Seq_MCF-7_Human1.12699027
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10227621
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09985912
89MAF_26560356_Chip-Seq_TH1_Human1.09844500
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.09838145
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09808968
92STAT3_23295773_ChIP-Seq_U87_Human1.09471920
93P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09214187
94UTX_26944678_Chip-Seq_JUKART_Human1.08572031
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07834128
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07323529
97RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07038735
98AR_25329375_ChIP-Seq_VCAP_Human1.06982507
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.06306508
100TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.06237770
101NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05567849
102TET1_21451524_ChIP-Seq_MESCs_Mouse1.05331967
103KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05033459
104KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05033459
105KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05033459
106P300_19829295_ChIP-Seq_ESCs_Human1.03722606
107OCT4_19829295_ChIP-Seq_ESCs_Human1.03491009
108RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02552051
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.01279668
110MAF_26560356_Chip-Seq_TH2_Human0.99987409
111TAF15_26573619_Chip-Seq_HEK293_Human0.99906174
112E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99276642
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99249284
114TP53_23651856_ChIP-Seq_MEFs_Mouse0.98848868
115ISL1_27105846_Chip-Seq_CPCs_Mouse0.98188909
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98060691
117* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97783828
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.97677059
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97551950
120SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97425176
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97278617
122AHR_22903824_ChIP-Seq_MCF-7_Human0.97092627
123TP53_16413492_ChIP-PET_HCT116_Human0.97092415
124VDR_24763502_ChIP-Seq_THP-1_Human0.96838895
125SMAD3_21741376_ChIP-Seq_ESCs_Human0.96390563
126MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96376165
127TCF4_23295773_ChIP-Seq_U87_Human0.96254789
128CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96127163
129DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95409342
130SMAD4_21741376_ChIP-Seq_HESCs_Human0.95075614
131TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94015193
132ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93913707
133CTCF_27219007_Chip-Seq_Bcells_Human0.92982194
134OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92450902
135TET1_21490601_ChIP-Seq_MESCs_Mouse0.91088197
136KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90917184
137PIAS1_25552417_ChIP-Seq_VCAP_Human0.90741458
138RNF2_27304074_Chip-Seq_NSC_Mouse0.90529163
139CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90399147
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89468051
141RXR_22108803_ChIP-Seq_LS180_Human0.89074077
142TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85316614
143SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84597847
144POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84411698
145TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84411698
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83645526
147OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83634629
148ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83439840
149PRDM14_20953172_ChIP-Seq_ESCs_Human0.82423518
150TP53_20018659_ChIP-ChIP_R1E_Mouse0.82341549

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004859_abnormal_synaptic_plasticity7.28694853
2MP0003880_abnormal_central_pattern4.45817645
3* MP0003635_abnormal_synaptic_transmissio4.35808985
4MP0004270_analgesia3.98272264
5* MP0002063_abnormal_learning/memory/cond3.49679019
6MP0009745_abnormal_behavioral_response3.43487279
7MP0002822_catalepsy3.15239743
8MP0002064_seizures3.10420929
9MP0005423_abnormal_somatic_nervous2.98316279
10MP0002572_abnormal_emotion/affect_behav2.83081890
11MP0009046_muscle_twitch2.81343764
12MP0003705_abnormal_hypodermis_morpholog2.73441371
13MP0001968_abnormal_touch/_nociception2.73002234
14MP0001486_abnormal_startle_reflex2.60970579
15MP0002734_abnormal_mechanical_nocicepti2.53817297
16MP0002272_abnormal_nervous_system2.40115223
17MP0009780_abnormal_chondrocyte_physiolo2.37689023
18MP0001348_abnormal_lacrimal_gland2.15476099
19MP0001501_abnormal_sleep_pattern2.10252458
20MP0002249_abnormal_larynx_morphology2.03732907
21MP0004858_abnormal_nervous_system2.01886226
22MP0005076_abnormal_cell_differentiation2.01289737
23MP0009278_abnormal_bone_marrow1.97046118
24MP0000778_abnormal_nervous_system1.96718718
25MP0001849_ear_inflammation1.95052286
26MP0001440_abnormal_grooming_behavior1.94668312
27MP0002735_abnormal_chemical_nociception1.91106570
28MP0008569_lethality_at_weaning1.89891783
29* MP0004811_abnormal_neuron_physiology1.89761777
30MP0002733_abnormal_thermal_nociception1.89579964
31MP0002736_abnormal_nociception_after1.89257055
32MP0002909_abnormal_adrenal_gland1.84445269
33MP0001970_abnormal_pain_threshold1.82266254
34MP0002557_abnormal_social/conspecific_i1.80272297
35MP0002184_abnormal_innervation1.75266669
36MP0002067_abnormal_sensory_capabilities1.73104642
37MP0003329_amyloid_beta_deposits1.66564510
38MP0003879_abnormal_hair_cell1.65916607
39MP0004885_abnormal_endolymph1.64238309
40MP0004924_abnormal_behavior1.63206135
41MP0005386_behavior/neurological_phenoty1.63206135
42MP0000955_abnormal_spinal_cord1.62599145
43MP0005646_abnormal_pituitary_gland1.61966435
44MP0003787_abnormal_imprinting1.47086911
45* MP0002882_abnormal_neuron_morphology1.44904725
46MP0000566_synostosis1.44289896
47MP0009672_abnormal_birth_weight1.42165422
48* MP0002066_abnormal_motor_capabilities/c1.38569048
49MP0001984_abnormal_olfaction1.37884680
50MP0003633_abnormal_nervous_system1.36517978
51MP0002089_abnormal_postnatal_growth/wei1.34753652
52MP0000569_abnormal_digit_pigmentation1.34479767
53MP0005377_hearing/vestibular/ear_phenot1.33618760
54MP0003878_abnormal_ear_physiology1.33618760
55MP0003283_abnormal_digestive_organ1.27471852
56* MP0002152_abnormal_brain_morphology1.21498095
57MP0005645_abnormal_hypothalamus_physiol1.19806335
58MP0000428_abnormal_craniofacial_morphol1.19620958
59MP0003123_paternal_imprinting1.18043613
60MP0001502_abnormal_circadian_rhythm1.12965265
61MP0003631_nervous_system_phenotype1.12552423
62MP0008961_abnormal_basal_metabolism1.10937615
63MP0003122_maternal_imprinting1.10809653
64MP0003115_abnormal_respiratory_system1.10391810
65MP0001346_abnormal_lacrimal_gland1.07272028
66MP0003279_aneurysm1.07106407
67MP0006276_abnormal_autonomic_nervous1.05658287
68MP0003075_altered_response_to1.05372989
69MP0003938_abnormal_ear_development1.05038236
70MP0000537_abnormal_urethra_morphology1.02808043
71MP0002116_abnormal_craniofacial_bone1.00350643
72MP0001529_abnormal_vocalization0.99739862
73MP0001177_atelectasis0.99514633
74MP0002396_abnormal_hematopoietic_system0.98342085
75MP0003091_abnormal_cell_migration0.96499907
76MP0001905_abnormal_dopamine_level0.95739244
77MP0000751_myopathy0.94423333
78MP0000678_abnormal_parathyroid_gland0.94367003
79* MP0002069_abnormal_eating/drinking_beha0.93591202
80MP0001188_hyperpigmentation0.93316593
81MP0008872_abnormal_physiological_respon0.92862832
82MP0002081_perinatal_lethality0.92232193
83MP0008874_decreased_physiological_sensi0.91133404
84MP0010030_abnormal_orbit_morphology0.91034154
85MP0003942_abnormal_urinary_system0.89010047
86MP0000631_abnormal_neuroendocrine_gland0.87514159
87MP0000534_abnormal_ureter_morphology0.87261092
88MP0004142_abnormal_muscle_tone0.86690708
89MP0003385_abnormal_body_wall0.86238396
90MP0005394_taste/olfaction_phenotype0.86074463
91MP0005499_abnormal_olfactory_system0.86074463
92MP0004085_abnormal_heartbeat0.85402941
93MP0005623_abnormal_meninges_morphology0.82432339
94MP0003119_abnormal_digestive_system0.82246350
95MP0004145_abnormal_muscle_electrophysio0.82219663
96MP0002229_neurodegeneration0.81712296
97MP0004130_abnormal_muscle_cell0.81427523
98MP0009703_decreased_birth_body0.81377420
99MP0003634_abnormal_glial_cell0.81008907
100MP0005503_abnormal_tendon_morphology0.80978317
101* MP0010768_mortality/aging0.77470625
102MP0005409_darkened_coat_color0.76870884
103MP0003690_abnormal_glial_cell0.76610397
104MP0003632_abnormal_nervous_system0.75379875
105MP0005167_abnormal_blood-brain_barrier0.75155953
106MP0003861_abnormal_nervous_system0.74567853
107MP0004133_heterotaxia0.72914025
108MP0002009_preneoplasia0.72697467
109MP0002932_abnormal_joint_morphology0.72587902
110MP0000579_abnormal_nail_morphology0.72118474
111MP0001963_abnormal_hearing_physiology0.72003484
112MP0005551_abnormal_eye_electrophysiolog0.71827682
113MP0002090_abnormal_vision0.70789584
114MP0005187_abnormal_penis_morphology0.70578683
115MP0004185_abnormal_adipocyte_glucose0.70417956
116MP0002752_abnormal_somatic_nervous0.69571110
117MP0004233_abnormal_muscle_weight0.69409053
118MP0000013_abnormal_adipose_tissue0.69406235
119MP0000432_abnormal_head_morphology0.69343406
120MP0005535_abnormal_body_temperature0.69063263
121MP0000733_abnormal_muscle_development0.68987804
122MP0002114_abnormal_axial_skeleton0.68049871
123MP0003137_abnormal_impulse_conducting0.67458671
124MP0002925_abnormal_cardiovascular_devel0.67198552
125MP0000920_abnormal_myelination0.67154411
126MP0004742_abnormal_vestibular_system0.67084829
127MP0002234_abnormal_pharynx_morphology0.66073596
128MP0004510_myositis0.65357503
129MP0003172_abnormal_lysosome_physiology0.64549477
130MP0002653_abnormal_ependyma_morphology0.61525821
131MP0001299_abnormal_eye_distance/0.61173421
132MP0000604_amyloidosis0.60635556
133MP0001485_abnormal_pinna_reflex0.58289044
134MP0004484_altered_response_of0.57920501
135MP0001943_abnormal_respiration0.57525226
136MP0010386_abnormal_urinary_bladder0.57502729
137* MP0010769_abnormal_survival0.57046625
138MP0001664_abnormal_digestion0.55806876
139MP0004215_abnormal_myocardial_fiber0.55025578
140* MP0002082_postnatal_lethality0.53519411
141* MP0010770_preweaning_lethality0.53519411

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.26169163
2Focal motor seizures (HP:0011153)7.09792079
3Focal seizures (HP:0007359)5.61201610
4Visual hallucinations (HP:0002367)4.98689832
5Progressive cerebellar ataxia (HP:0002073)4.11305772
6Action tremor (HP:0002345)3.82588680
7* Epileptic encephalopathy (HP:0200134)3.75824520
8Febrile seizures (HP:0002373)3.73898657
9Broad-based gait (HP:0002136)3.59953463
10Atonic seizures (HP:0010819)3.58443425
11Absence seizures (HP:0002121)3.57005049
12Poor eye contact (HP:0000817)3.55161704
13Generalized tonic-clonic seizures (HP:0002069)3.52364909
14Papilledema (HP:0001085)3.52005147
15Supranuclear gaze palsy (HP:0000605)3.51222494
16Impaired vibration sensation in the lower limbs (HP:0002166)3.50838666
17Ankle clonus (HP:0011448)3.50344621
18Dialeptic seizures (HP:0011146)3.28142342
19Turricephaly (HP:0000262)3.28018319
20Urinary bladder sphincter dysfunction (HP:0002839)3.27738669
21Depression (HP:0000716)3.24957640
22Shallow orbits (HP:0000586)3.21199921
23Impaired social interactions (HP:0000735)3.19219098
24Abnormal social behavior (HP:0012433)3.19219098
25Genetic anticipation (HP:0003743)3.16254080
26Gaze-evoked nystagmus (HP:0000640)3.13662405
27Mutism (HP:0002300)3.11599721
28Abnormality of the lower motor neuron (HP:0002366)3.06544680
29Bronchomalacia (HP:0002780)3.03917192
30Dysdiadochokinesis (HP:0002075)3.03150669
31Postural instability (HP:0002172)2.98494481
32Dysmetria (HP:0001310)2.91276376
33Abnormality of the fingertips (HP:0001211)2.90963058
34Broad metatarsal (HP:0001783)2.87290155
35Anxiety (HP:0000739)2.86747839
36Amblyopia (HP:0000646)2.86454084
37Hyperventilation (HP:0002883)2.76585647
38Megalencephaly (HP:0001355)2.76397972
39Abnormal eating behavior (HP:0100738)2.74170447
40Impaired smooth pursuit (HP:0007772)2.73173762
41Drooling (HP:0002307)2.72997747
42Excessive salivation (HP:0003781)2.72997747
43Stereotypic behavior (HP:0000733)2.70614296
44Obstructive sleep apnea (HP:0002870)2.69473979
45Urinary urgency (HP:0000012)2.66301150
46Truncal ataxia (HP:0002078)2.66106153
47Hemiparesis (HP:0001269)2.63605596
48Annular pancreas (HP:0001734)2.61033231
49Broad face (HP:0000283)2.54577697
50Pointed chin (HP:0000307)2.50154478
51Hemiplegia (HP:0002301)2.49561961
52Spastic gait (HP:0002064)2.48133552
53Insomnia (HP:0100785)2.44561187
54Intention tremor (HP:0002080)2.43185481
55Epileptiform EEG discharges (HP:0011182)2.41477649
56Abnormality of binocular vision (HP:0011514)2.39876549
57Diplopia (HP:0000651)2.39876549
58Cerebral inclusion bodies (HP:0100314)2.39072213
59Abnormality of ocular smooth pursuit (HP:0000617)2.38325813
60Bradykinesia (HP:0002067)2.37693830
61Trigonocephaly (HP:0000243)2.36974509
62Impaired vibratory sensation (HP:0002495)2.35901981
63Urethral obstruction (HP:0000796)2.35640519
64Neurofibrillary tangles (HP:0002185)2.30833504
65EEG with generalized epileptiform discharges (HP:0011198)2.29845996
66Dysmetric saccades (HP:0000641)2.24769582
67Absent speech (HP:0001344)2.23221671
68Hypsarrhythmia (HP:0002521)2.22998924
69Ventricular fibrillation (HP:0001663)2.22145707
70Abnormality of the aortic arch (HP:0012303)2.21833113
71* Torticollis (HP:0000473)2.20163860
72Ankyloglossia (HP:0010296)2.17771411
73Insidious onset (HP:0003587)2.17149414
74Termporal pattern (HP:0011008)2.17149414
75Amyotrophic lateral sclerosis (HP:0007354)2.16635441
76Abnormality of the corticospinal tract (HP:0002492)2.16612493
77Lower limb muscle weakness (HP:0007340)2.16388822
78Scanning speech (HP:0002168)2.15669261
79Lower limb amyotrophy (HP:0007210)2.15381964
80* Focal dystonia (HP:0004373)2.13861203
81Progressive inability to walk (HP:0002505)2.12140081
82Arnold-Chiari malformation (HP:0002308)2.08830603
83Cerebral aneurysm (HP:0004944)2.07699888
84Tracheomalacia (HP:0002779)2.00147743
85Inappropriate behavior (HP:0000719)1.99806256
86Bundle branch block (HP:0011710)1.99656112
87Peripheral hypomyelination (HP:0007182)1.98923034
88Broad thumb (HP:0011304)1.98568335
89Vertebral arch anomaly (HP:0008438)1.98046265
90Long eyelashes (HP:0000527)1.97733568
91Broad palm (HP:0001169)1.97542122
92Agitation (HP:0000713)1.96885806
93Status epilepticus (HP:0002133)1.96879983
94Ulnar bowing (HP:0003031)1.95712774
95Distal upper limb amyotrophy (HP:0007149)1.95459969
96Upper limb amyotrophy (HP:0009129)1.95459969
97Disproportionate tall stature (HP:0001519)1.94993644
98Bowel incontinence (HP:0002607)1.94435601
99Fetal akinesia sequence (HP:0001989)1.93905669
100Narrow palate (HP:0000189)1.93242134
101Limb dystonia (HP:0002451)1.91953774
102Precocious puberty (HP:0000826)1.90933856
103Thin ribs (HP:0000883)1.90866924
104Long palpebral fissure (HP:0000637)1.90697066
105Broad phalanges of the hand (HP:0009768)1.90229456
106Generalized myoclonic seizures (HP:0002123)1.89767529
107Broad finger (HP:0001500)1.89002354
108Incomplete penetrance (HP:0003829)1.88535090
109Atelectasis (HP:0100750)1.88289879
110Apathy (HP:0000741)1.88077576
111Metaphyseal cupping (HP:0003021)1.85897591
112Clonus (HP:0002169)1.85886456
113Abnormal EKG (HP:0003115)1.83506897
114Renovascular hypertension (HP:0100817)1.83221750
115Supernumerary ribs (HP:0005815)1.82157974
116Lower limb asymmetry (HP:0100559)1.81791379
117Abnormality of the distal phalanx of the thumb (HP:0009617)1.80530112
118Inability to walk (HP:0002540)1.79844471
119Protrusio acetabuli (HP:0003179)1.79608946
120Spinal canal stenosis (HP:0003416)1.79232780
121Obsessive-compulsive behavior (HP:0000722)1.79166796
122Intellectual disability, profound (HP:0002187)1.78225959
123Abnormality of salivation (HP:0100755)1.77314600
124Deep palmar crease (HP:0006191)1.77174135
125Gait ataxia (HP:0002066)1.76947292
126Overriding aorta (HP:0002623)1.76854198
127Polyphagia (HP:0002591)1.76096132
128Aqueductal stenosis (HP:0002410)1.75056964
129Neuronal loss in central nervous system (HP:0002529)1.74426788
130Aplasia involving bones of the extremities (HP:0009825)1.73003501
131Aplasia involving bones of the upper limbs (HP:0009823)1.73003501
132Aplasia of the phalanges of the hand (HP:0009802)1.73003501
133Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.73002297
134Short 4th metacarpal (HP:0010044)1.73002297
135Macroorchidism (HP:0000053)1.72909020
136Choanal stenosis (HP:0000452)1.72761857
137Rapidly progressive (HP:0003678)1.71712976
138Broad long bones (HP:0005622)1.71098793
139Hyperacusis (HP:0010780)1.70336093
140Hypoventilation (HP:0002791)1.70316042
141Hand muscle atrophy (HP:0009130)1.69922911
142Abnormality of the columella (HP:0009929)1.69541601
143Genu recurvatum (HP:0002816)1.69434582
144Broad phalanx (HP:0006009)1.69374561
145Sleep apnea (HP:0010535)1.69034562
146* Craniofacial dystonia (HP:0012179)1.69004358
147Mild short stature (HP:0003502)1.68531681
148Deeply set eye (HP:0000490)1.68248360
149Resting tremor (HP:0002322)1.68245234
150Abnormal large intestine physiology (HP:0012700)1.66954211
151Vitreoretinal degeneration (HP:0000655)1.66082029
152Bell-shaped thorax (HP:0001591)1.66038270
153Neoplasm of the heart (HP:0100544)1.66019104
154Spina bifida occulta (HP:0003298)1.64827973
155Heterotopia (HP:0002282)1.64773433
156Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.62652822
157Dislocated radial head (HP:0003083)1.62565723
158Elfin facies (HP:0004428)1.62114029
159Bowel diverticulosis (HP:0005222)1.60411992
160Mitral valve prolapse (HP:0001634)1.60254525
161Mitral regurgitation (HP:0001653)1.59938222

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.71068579
2NTRK34.42866040
3MAP3K93.91377219
4MARK13.52830820
5CDK123.42862087
6TRIB33.20514723
7DAPK22.78799785
8PRKD32.76269993
9MINK12.69148532
10MAP3K42.67523456
11MAP3K102.66510211
12PAK62.49254447
13EEF2K2.32822951
14NTRK22.26539949
15KSR22.19547528
16SMG12.13084303
17CAMKK12.11255510
18MAP2K72.10245637
19SIK11.82889914
20NTRK11.81955916
21KSR11.81448987
22DAPK11.78455075
23FGFR41.71827317
24MAPK151.67381276
25CDK51.62877692
26SIK21.59188222
27MAP2K41.57015793
28BRD41.55438913
29CAMK1D1.48275190
30TNIK1.46787272
31STK381.46724591
32RIPK41.43225833
33TAOK11.42885522
34TYRO31.36574462
35PRPF4B1.33063955
36FES1.25436473
37MAPK131.25383285
38MAP3K21.21685772
39LATS21.21028883
40PLK21.20658094
41PNCK1.19409928
42PRKCG1.18052525
43UHMK11.14479955
44GRK51.10747455
45MAP3K121.10524047
46CASK1.10111933
47MTOR1.08533982
48CAMK11.07831919
49STK111.04171299
50CDK191.03033124
51PHKG21.02639715
52PHKG11.02639715
53ALK0.95715695
54PRKCH0.93370386
55CDK180.93016073
56CDK150.92310756
57MARK20.91824223
58MAP3K130.90523827
59HIPK20.88709233
60BMX0.88606544
61RAF10.87709145
62ARAF0.87623049
63RIPK10.87014541
64CDK140.86429866
65CAMKK20.86210539
66RET0.84792989
67CDK11A0.81323600
68PAK30.80731358
69PKN20.80274847
70PTK2B0.79778546
71FGFR30.79010206
72* CAMK2A0.78290411
73MAPK120.77024190
74CAMK1G0.75755892
75WNK10.75552353
76SGK2230.72556385
77SGK4940.72556385
78SGK10.71359714
79CAMK2B0.70153913
80MAP4K10.70077516
81ERN10.69810388
82DYRK1A0.68370681
83PDK10.68344509
84SIK30.68149332
85SGK30.67344576
86DMPK0.66863804
87CSNK1G20.66384158
88MAPK70.65053375
89PDGFRB0.63710228
90SGK20.63505745
91PTK60.63427747
92LMTK20.62232925
93RPS6KL10.60765953
94RPS6KC10.60765953
95CDC42BPA0.60079776
96PASK0.58197503
97PDPK10.57715927
98PRKCZ0.57004029
99MAP3K70.56725908
100ICK0.56093895
101CAMK40.56075718
102MAP3K10.55517237
103RPS6KA30.54678338
104FYN0.50976508
105DYRK1B0.50282369
106ERBB20.50017582
107DDR20.50009033
108PINK10.48879401
109EPHB10.48690442
110MAPK100.46991459
111NEK60.46703513
112BRSK10.46384648
113GSK3B0.45131895
114TTN0.44386482
115RPS6KA60.42596482
116PDGFRA0.42203251
117CDK40.41774301
118MAP2K20.41501991
119DAPK30.41216185
120SCYL20.41172499
121RPS6KA20.41156506
122PRKD20.39367128
123TNK20.38768229
124BMPR20.37845276
125ZAP700.37409812
126PRKCE0.36859423
127PTK20.35575847
128NEK10.35480671
129CDK20.34064352
130PAK20.33176271
131FGFR20.32485498
132FER0.31807483
133PRKCB0.31764725
134MAP2K10.31506604
135FGR0.31345903
136MAP3K60.30968083
137MAPK80.29784955
138OXSR10.29654154

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.36364398
2Synaptic vesicle cycle_Homo sapiens_hsa047212.90532077
3Olfactory transduction_Homo sapiens_hsa047402.80950106
4Circadian entrainment_Homo sapiens_hsa047132.74978569
5Long-term potentiation_Homo sapiens_hsa047202.71764892
6Glutamatergic synapse_Homo sapiens_hsa047242.60132049
7GABAergic synapse_Homo sapiens_hsa047272.52373562
8Amphetamine addiction_Homo sapiens_hsa050312.50493984
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.45606141
10Morphine addiction_Homo sapiens_hsa050322.38970270
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23119875
12Salivary secretion_Homo sapiens_hsa049702.16075564
13Dopaminergic synapse_Homo sapiens_hsa047282.14638011
14Insulin secretion_Homo sapiens_hsa049112.04771485
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.97270511
16Cholinergic synapse_Homo sapiens_hsa047251.96923909
17Gastric acid secretion_Homo sapiens_hsa049711.94306252
18Cocaine addiction_Homo sapiens_hsa050301.74459449
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74017195
20Notch signaling pathway_Homo sapiens_hsa043301.72969905
21Oxytocin signaling pathway_Homo sapiens_hsa049211.71732273
22Renin secretion_Homo sapiens_hsa049241.65839807
23Long-term depression_Homo sapiens_hsa047301.60375954
24Calcium signaling pathway_Homo sapiens_hsa040201.57657984
25GnRH signaling pathway_Homo sapiens_hsa049121.51647525
26Taste transduction_Homo sapiens_hsa047421.48872733
27Serotonergic synapse_Homo sapiens_hsa047261.47067259
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43975107
29Gap junction_Homo sapiens_hsa045401.39940671
30Chronic myeloid leukemia_Homo sapiens_hsa052201.38482331
31Glioma_Homo sapiens_hsa052141.37045445
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35943525
33Type II diabetes mellitus_Homo sapiens_hsa049301.33948746
34cAMP signaling pathway_Homo sapiens_hsa040241.33877649
35Axon guidance_Homo sapiens_hsa043601.27865285
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26833756
37Acute myeloid leukemia_Homo sapiens_hsa052211.25621371
38Nitrogen metabolism_Homo sapiens_hsa009101.25172621
39Estrogen signaling pathway_Homo sapiens_hsa049151.24827207
40Melanogenesis_Homo sapiens_hsa049161.18160981
41ErbB signaling pathway_Homo sapiens_hsa040121.16047779
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15992740
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10416099
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10168164
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02449449
46Basal cell carcinoma_Homo sapiens_hsa052171.01904119
47Adherens junction_Homo sapiens_hsa045201.01532344
48Dorso-ventral axis formation_Homo sapiens_hsa043200.99736314
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96702882
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.94754988
51Thyroid cancer_Homo sapiens_hsa052160.94575307
52Oocyte meiosis_Homo sapiens_hsa041140.94023931
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.93891182
54B cell receptor signaling pathway_Homo sapiens_hsa046620.91857987
55MicroRNAs in cancer_Homo sapiens_hsa052060.90713593
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90431923
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89736695
58T cell receptor signaling pathway_Homo sapiens_hsa046600.85880652
59Prostate cancer_Homo sapiens_hsa052150.84657639
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84299612
61Pancreatic secretion_Homo sapiens_hsa049720.84016050
62Pancreatic cancer_Homo sapiens_hsa052120.83509055
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82505110
64Lysine degradation_Homo sapiens_hsa003100.81705815
65Dilated cardiomyopathy_Homo sapiens_hsa054140.80836252
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79898824
67Choline metabolism in cancer_Homo sapiens_hsa052310.79790218
68Hippo signaling pathway_Homo sapiens_hsa043900.79602476
69Thyroid hormone synthesis_Homo sapiens_hsa049180.79028811
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.78890147
71VEGF signaling pathway_Homo sapiens_hsa043700.78252616
72mRNA surveillance pathway_Homo sapiens_hsa030150.77529113
73Collecting duct acid secretion_Homo sapiens_hsa049660.76892559
74MAPK signaling pathway_Homo sapiens_hsa040100.75850726
75Hedgehog signaling pathway_Homo sapiens_hsa043400.75806567
76Focal adhesion_Homo sapiens_hsa045100.74935970
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74912863
78Phototransduction_Homo sapiens_hsa047440.72619134
79mTOR signaling pathway_Homo sapiens_hsa041500.72549439
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71725987
81Cardiac muscle contraction_Homo sapiens_hsa042600.71466550
82Rap1 signaling pathway_Homo sapiens_hsa040150.69947839
83Proteoglycans in cancer_Homo sapiens_hsa052050.69126697
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69036016
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66909304
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.66276729
87Endometrial cancer_Homo sapiens_hsa052130.65724466
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64953901
89Glucagon signaling pathway_Homo sapiens_hsa049220.64487084
90Non-small cell lung cancer_Homo sapiens_hsa052230.62891848
91* Ras signaling pathway_Homo sapiens_hsa040140.61322656
92Wnt signaling pathway_Homo sapiens_hsa043100.61186500
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61165284
94Amoebiasis_Homo sapiens_hsa051460.60487480
95AMPK signaling pathway_Homo sapiens_hsa041520.60467243
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.58976146
97Pathways in cancer_Homo sapiens_hsa052000.56683821
98Endocytosis_Homo sapiens_hsa041440.55902286
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55412014
100Alcoholism_Homo sapiens_hsa050340.55218872
101Vibrio cholerae infection_Homo sapiens_hsa051100.52936010
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52900006
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52891795
104Renal cell carcinoma_Homo sapiens_hsa052110.52636334
105Bile secretion_Homo sapiens_hsa049760.49096063
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47350039
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46987072
108Insulin signaling pathway_Homo sapiens_hsa049100.46440929
109Circadian rhythm_Homo sapiens_hsa047100.45826295
110Prion diseases_Homo sapiens_hsa050200.44402964
111Inositol phosphate metabolism_Homo sapiens_hsa005620.44027130
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43726299
113Colorectal cancer_Homo sapiens_hsa052100.42188870
114Type I diabetes mellitus_Homo sapiens_hsa049400.41446322
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39867542
116Chemokine signaling pathway_Homo sapiens_hsa040620.39476245
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38278561
118Ovarian steroidogenesis_Homo sapiens_hsa049130.37860071
119African trypanosomiasis_Homo sapiens_hsa051430.35222127
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35096984
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33649704
122Platelet activation_Homo sapiens_hsa046110.31207646
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.29791342
124Tight junction_Homo sapiens_hsa045300.28967399
125Prolactin signaling pathway_Homo sapiens_hsa049170.28560241

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