SYNE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)5.48935126
2melanin metabolic process (GO:0006582)4.85261089
3phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.74087040
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.61758508
5secondary metabolite biosynthetic process (GO:0044550)4.56742501
6monoubiquitinated protein deubiquitination (GO:0035520)4.43131440
7cilium or flagellum-dependent cell motility (GO:0001539)4.40178289
8histone H3-K4 trimethylation (GO:0080182)4.36962414
9negative regulation of translation, ncRNA-mediated (GO:0040033)4.36335532
10regulation of translation, ncRNA-mediated (GO:0045974)4.36335532
11negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.36335532
12neural tube formation (GO:0001841)4.35026994
13hemidesmosome assembly (GO:0031581)4.04333282
14establishment of protein localization to Golgi (GO:0072600)3.90870296
15peptidyl-lysine trimethylation (GO:0018023)3.86501038
16cytoplasmic mRNA processing body assembly (GO:0033962)3.80286955
17cilium movement (GO:0003341)3.66561002
18embryonic retina morphogenesis in camera-type eye (GO:0060059)3.55823159
19protein K11-linked deubiquitination (GO:0035871)3.50205894
20regulation of cardioblast differentiation (GO:0051890)3.46834268
21hippo signaling (GO:0035329)3.39268321
22protein targeting to Golgi (GO:0000042)3.37657446
23retrograde transport, vesicle recycling within Golgi (GO:0000301)3.37136006
24pre-miRNA processing (GO:0031054)3.34430686
25olfactory bulb development (GO:0021772)3.32989121
26histone H3-K9 methylation (GO:0051567)3.31352292
27histone mRNA catabolic process (GO:0071044)3.27242581
28protein K48-linked deubiquitination (GO:0071108)3.26515870
29epithelial cilium movement (GO:0003351)3.26288697
30peptidyl-lysine methylation (GO:0018022)3.25167242
31mitotic sister chromatid cohesion (GO:0007064)3.23510914
32dorsal/ventral axis specification (GO:0009950)3.23480244
33histone H3-K9 modification (GO:0061647)3.21739984
34interkinetic nuclear migration (GO:0022027)3.12896076
35regulation of pigment cell differentiation (GO:0050932)3.12512359
36microtubule anchoring (GO:0034453)3.12296157
37regulation of cardioblast proliferation (GO:0003264)3.11490792
38regulation of secondary heart field cardioblast proliferation (GO:0003266)3.11490792
39activated T cell proliferation (GO:0050798)3.10917445
40mitotic chromosome condensation (GO:0007076)3.10427032
41histone-serine phosphorylation (GO:0035404)3.10291029
42dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.08327711
43atrioventricular valve morphogenesis (GO:0003181)3.07634745
44* nucleus localization (GO:0051647)3.06482209
45positive regulation of fatty acid beta-oxidation (GO:0032000)3.02754576
46regulation of endothelial cell chemotaxis (GO:2001026)3.01676955
47gonadal mesoderm development (GO:0007506)2.98973261
48morphogenesis of an epithelial sheet (GO:0002011)2.97606614
49paraxial mesoderm development (GO:0048339)2.96895784
50nuclear pore complex assembly (GO:0051292)2.96061917
51positive regulation of developmental pigmentation (GO:0048087)2.95547672
52insulin-like growth factor receptor signaling pathway (GO:0048009)2.94711341
53desmosome organization (GO:0002934)2.91237518
54tyrosine metabolic process (GO:0006570)2.90793232
55embryonic foregut morphogenesis (GO:0048617)2.88037283
56histone lysine methylation (GO:0034968)2.87040634
57gastrulation with mouth forming second (GO:0001702)2.86513788
58intraciliary transport (GO:0042073)2.83749561
59growth hormone receptor signaling pathway (GO:0060396)2.82619163
60histone H3-K4 methylation (GO:0051568)2.80872364
61carnitine shuttle (GO:0006853)2.79055048
62oocyte development (GO:0048599)2.77770630
63atrial septum morphogenesis (GO:0060413)2.77568581
64appendage development (GO:0048736)2.76913499
65limb development (GO:0060173)2.76913499
66genitalia morphogenesis (GO:0035112)2.74894283
67fatty acid transmembrane transport (GO:1902001)2.73718712
68negative T cell selection (GO:0043383)2.73500502
69forebrain neuron differentiation (GO:0021879)2.72822631
70histone H3-K9 demethylation (GO:0033169)2.72520917
71pericardium development (GO:0060039)2.71439031
72regulation of protein polyubiquitination (GO:1902914)2.66499349
73endocardial cushion development (GO:0003197)2.65906748
74regulation of fatty acid beta-oxidation (GO:0031998)2.64869802
75regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.64792195
76regulation of hippo signaling (GO:0035330)2.63816450
77cerebellar Purkinje cell differentiation (GO:0021702)2.63382971
78cellular response to ethanol (GO:0071361)2.62239705
79cellular response to growth hormone stimulus (GO:0071378)2.59965767
80positive regulation of catenin import into nucleus (GO:0035413)2.59578450
81regulation of transforming growth factor beta2 production (GO:0032909)2.58886181
82regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.58412743
83epithelial cell differentiation involved in prostate gland development (GO:0060742)2.57898740
84axonemal dynein complex assembly (GO:0070286)2.57749126
85axoneme assembly (GO:0035082)2.57478202
86replicative senescence (GO:0090399)2.57087541
87central nervous system neuron axonogenesis (GO:0021955)2.57017275
88regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.56789146
89macroautophagy (GO:0016236)2.55782114
90coronary vasculature morphogenesis (GO:0060977)2.55633417
91negative thymic T cell selection (GO:0045060)2.55359665
92heart morphogenesis (GO:0003007)2.54450686
93regulation of DNA endoreduplication (GO:0032875)2.54310091
94regulation of establishment of cell polarity (GO:2000114)2.54261980
95central nervous system projection neuron axonogenesis (GO:0021952)2.53301940
96endothelial cell morphogenesis (GO:0001886)2.53158085
97regulation of heart morphogenesis (GO:2000826)2.53143135
98nuclear pore organization (GO:0006999)2.52894223
99cilium organization (GO:0044782)2.52046608
100radial glial cell differentiation (GO:0060019)2.50932914
101regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.49201457
102amino-acid betaine transport (GO:0015838)2.48709520
103carnitine transport (GO:0015879)2.48709520
104glomerular basement membrane development (GO:0032836)2.48021342
105endocardial cushion morphogenesis (GO:0003203)2.47721057
106carnitine transmembrane transport (GO:1902603)2.47467921
107low-density lipoprotein particle clearance (GO:0034383)2.47443200
108cilium assembly (GO:0042384)2.47409053
109peptidyl-lysine dimethylation (GO:0018027)2.47353226
110skeletal muscle adaptation (GO:0043501)2.44940250
111positive regulation of fatty acid oxidation (GO:0046321)2.44930853
112histone lysine demethylation (GO:0070076)2.44413376
113neuronal stem cell maintenance (GO:0097150)2.44389077
114striated muscle atrophy (GO:0014891)2.44309573
115regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.44040322
116centriole replication (GO:0007099)2.43974363
117negative regulation of DNA repair (GO:0045738)2.42249761
118negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.42120013
119cell-substrate junction assembly (GO:0007044)2.41432963
120protein localization to Golgi apparatus (GO:0034067)2.41027669
121regulation of RNA export from nucleus (GO:0046831)2.40934857
122sister chromatid cohesion (GO:0007062)2.40402737
123bundle of His cell to Purkinje myocyte communication (GO:0086069)2.40258888
124regulation of establishment or maintenance of cell polarity (GO:0032878)2.40189350
125planar cell polarity pathway involved in neural tube closure (GO:0090179)2.39819154
126regulation of sister chromatid cohesion (GO:0007063)2.39784694
127positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.39069758
128ectoderm development (GO:0007398)2.39028116
129N-terminal protein amino acid acetylation (GO:0006474)2.38779128
130positive T cell selection (GO:0043368)2.38712651
131regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.38244430
132renal system development (GO:0072001)2.37909408
133protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.37721456
134histone H3-K36 demethylation (GO:0070544)2.36571878
135protein K63-linked deubiquitination (GO:0070536)2.36350474
136regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.36002914
137snRNA transcription (GO:0009301)2.35921620
138regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.35620596
139anatomical structure regression (GO:0060033)2.35090074
140regulation of protein glycosylation (GO:0060049)2.34900600
141axon extension involved in axon guidance (GO:0048846)2.34802803
142neuron projection extension involved in neuron projection guidance (GO:1902284)2.34802803
143intracellular lipid transport (GO:0032365)2.34084925
144positive regulation of histone deacetylation (GO:0031065)2.33050169
145regulation of growth hormone secretion (GO:0060123)2.31380910
146pore complex assembly (GO:0046931)2.30713271
147apoptotic cell clearance (GO:0043277)2.30585367
148regulation of somitogenesis (GO:0014807)2.29548467
149tongue development (GO:0043586)2.29517257
150cellular response to interferon-alpha (GO:0035457)2.28986507
151histone H4-K16 acetylation (GO:0043984)2.28409523
152regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.27856571
153embryonic camera-type eye morphogenesis (GO:0048596)2.27765248
154cornea development in camera-type eye (GO:0061303)2.27508685
155histone demethylation (GO:0016577)2.26544575
156lymph vessel development (GO:0001945)2.26425755
157male genitalia development (GO:0030539)2.26308288
158protein localization to microtubule cytoskeleton (GO:0072698)2.26271065
159regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.25954291
160positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.25581534
161regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.25581534
162renal filtration (GO:0097205)2.25561544
163embryonic epithelial tube formation (GO:0001838)2.25411939
164regulation of B cell receptor signaling pathway (GO:0050855)2.25114862
165limb bud formation (GO:0060174)2.25092807
166cell surface receptor signaling pathway involved in heart development (GO:0061311)2.24734428
167cellular component assembly involved in morphogenesis (GO:0010927)2.24615440
168regulation of timing of cell differentiation (GO:0048505)2.24375735
169negative regulation of neurotransmitter transport (GO:0051589)2.24336918
170glomerulus development (GO:0032835)2.24104583
171artery development (GO:0060840)2.23724991
172positive regulation of male gonad development (GO:2000020)2.23599099
173basement membrane organization (GO:0071711)2.23242542
174* establishment of nucleus localization (GO:0040023)2.22954023
175left/right axis specification (GO:0070986)2.22783076
176cilium morphogenesis (GO:0060271)2.22623589
177metanephric mesenchyme development (GO:0072075)2.22576652
178positive regulation of hormone biosynthetic process (GO:0046886)2.22554311
179sex determination (GO:0007530)2.22234336
180somite development (GO:0061053)2.22153777
181rRNA catabolic process (GO:0016075)2.21372566
182cardiovascular system development (GO:0072358)2.21282599
183retina layer formation (GO:0010842)2.21092206
184* fibroblast migration (GO:0010761)2.20313538
185retina vasculature morphogenesis in camera-type eye (GO:0061299)2.19838099
186regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.19103988
187vascular endothelial growth factor signaling pathway (GO:0038084)2.18886212
188glomerular filtration (GO:0003094)2.18681118

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.16866032
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.53768884
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76672625
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.72388209
5CLOCK_20551151_ChIP-Seq_293T_Human2.71268885
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.51438770
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.49212127
8* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45551741
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.43301055
10SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.41327353
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.40289706
12GBX2_23144817_ChIP-Seq_PC3_Human2.37167497
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35308827
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.32413515
15EZH2_22144423_ChIP-Seq_EOC_Human2.19811302
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18175265
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.13719683
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04203018
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02537824
20TAF15_26573619_Chip-Seq_HEK293_Human2.02347570
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00180959
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.99959188
23* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.99856223
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95731863
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.93234128
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92221929
27SOX9_24532713_ChIP-Seq_HFSC_Mouse1.92134086
28E2F7_22180533_ChIP-Seq_HELA_Human1.90552414
29SMAD4_21799915_ChIP-Seq_A2780_Human1.85584350
30* STAT3_23295773_ChIP-Seq_U87_Human1.83835003
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.82667148
32IGF1R_20145208_ChIP-Seq_DFB_Human1.82087757
33* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.81002427
34ZNF263_19887448_ChIP-Seq_K562_Human1.80554525
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.80192448
36AR_21572438_ChIP-Seq_LNCaP_Human1.79967313
37* EP300_21415370_ChIP-Seq_HL-1_Mouse1.79682065
38FUS_26573619_Chip-Seq_HEK293_Human1.76468394
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.75775883
40TCF4_18268006_ChIP-ChIP_LS174T_Human1.74764064
41ISL1_27105846_Chip-Seq_CPCs_Mouse1.74443805
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.74149188
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74149188
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.72934951
45LXR_22158963_ChIP-Seq_LIVER_Mouse1.72815941
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.71032531
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.70132111
48FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.68482486
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.67449019
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.65399635
51* P300_19829295_ChIP-Seq_ESCs_Human1.64751994
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.64081752
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63688208
54* TCF4_23295773_ChIP-Seq_U87_Human1.61801228
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61492156
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60488706
57GATA1_22025678_ChIP-Seq_K562_Human1.60072488
58* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.58369493
59CJUN_26792858_Chip-Seq_BT549_Human1.58246789
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57676472
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.56300215
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.53641042
63* FOXA2_19822575_ChIP-Seq_HepG2_Human1.53620029
64AHR_22903824_ChIP-Seq_MCF-7_Human1.50237746
65EWS_26573619_Chip-Seq_HEK293_Human1.50224029
66* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50167587
67* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50167587
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.49228592
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.49100550
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48699113
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48023814
72AR_21909140_ChIP-Seq_LNCAP_Human1.47961406
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46825799
74TP53_16413492_ChIP-PET_HCT116_Human1.46466322
75* TBX20_22080862_ChIP-Seq_HEART_Mouse1.44253056
76* TBX20_22328084_ChIP-Seq_HEART_Mouse1.44253056
77* ER_23166858_ChIP-Seq_MCF-7_Human1.44141365
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43309148
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.43126668
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41981907
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41305930
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40781458
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40470211
84BRD4_25478319_ChIP-Seq_HGPS_Human1.40176940
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40084265
86CBP_20019798_ChIP-Seq_JUKART_Human1.40084265
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39068190
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38249650
89SALL4_18804426_ChIP-ChIP_XEN_Mouse1.37917252
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.37844200
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36654980
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.36496168
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36464309
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35463616
95ZNF274_21170338_ChIP-Seq_K562_Hela1.35331511
96ARNT_22903824_ChIP-Seq_MCF-7_Human1.34660179
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34423206
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33629338
99VDR_22108803_ChIP-Seq_LS180_Human1.33141534
100RXR_22158963_ChIP-Seq_LIVER_Mouse1.32735323
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.32341000
102AR_25329375_ChIP-Seq_VCAP_Human1.32110279
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30249270
104* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29409810
105CTNNB1_20460455_ChIP-Seq_HCT116_Human1.28817679
106FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.28598876
107CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.28181791
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27886002
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27553580
110SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27106335
111NFE2_27457419_Chip-Seq_LIVER_Mouse1.27061142
112* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25850875
113NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23472993
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23424070
115CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.23412445
116PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.23230049
117PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22868124
118GATA6_25053715_ChIP-Seq_YYC3_Human1.22184246
119ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.22112392
120* FLI1_21867929_ChIP-Seq_TH2_Mouse1.21723934
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21258146
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20423954
123UBF1/2_26484160_Chip-Seq_HMECs_Human1.19830262
124E2F1_18555785_Chip-Seq_ESCs_Mouse1.18816621
125* RUNX2_22187159_ChIP-Seq_PCA_Human1.18242691
126STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18022647
127* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17700897
128TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16583223
129* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16472192
130* RXR_22108803_ChIP-Seq_LS180_Human1.16244791
131P53_22387025_ChIP-Seq_ESCs_Mouse1.14291706
132GATA4_25053715_ChIP-Seq_YYC3_Human1.14260048
133* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14257084
134RUNX_20019798_ChIP-Seq_JUKART_Human1.14163258
135KDM2B_26808549_Chip-Seq_REH_Human1.14077492
136WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13384552
137P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13370296
138* TCF4_22108803_ChIP-Seq_LS180_Human1.12984612
139FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12843749
140DROSHA_22980978_ChIP-Seq_HELA_Human1.11621728
141* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11214242
142CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09577738
143PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09305490
144SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09298578
145* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09281367
146RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08970430
147FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08751453
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07747089
149CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07350042
150AR_19668381_ChIP-Seq_PC3_Human1.07115552
151ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06334434
152WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05181905
153* PRDM14_20953172_ChIP-Seq_ESCs_Human1.05167483
154TBL1_22424771_ChIP-Seq_293T_Human1.04725968
155GATA2_21666600_ChIP-Seq_HMVEC_Human1.02766419
156ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02460357
157TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02011111
158TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01501184
159CMYC_18555785_Chip-Seq_ESCs_Mouse1.00572133
160STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00155857
161SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99800943
162* BCAT_22108803_ChIP-Seq_LS180_Human0.99012076
163SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98761057
164* CRX_20693478_ChIP-Seq_RETINA_Mouse0.98517129
165TP63_23658742_ChIP-Seq_EP156T_Human0.97280218
166* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95338859
167FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94095531
168FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93731987
169ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93461456
170TP63_19390658_ChIP-ChIP_HaCaT_Human0.91733368
171* GATA3_24758297_ChIP-Seq_MCF-7_Human0.91501266
172ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91197897
173RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90029933
174KLF5_25053715_ChIP-Seq_YYC3_Human0.89459987

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.09027256
2MP0003787_abnormal_imprinting3.75782758
3MP0003705_abnormal_hypodermis_morpholog3.42207942
4MP0005171_absent_coat_pigmentation3.12684648
5MP0000372_irregular_coat_pigmentation3.02998487
6MP0006292_abnormal_olfactory_placode2.96084928
7MP0010234_abnormal_vibrissa_follicle2.57985728
8MP0003878_abnormal_ear_physiology2.56426557
9MP0005377_hearing/vestibular/ear_phenot2.56426557
10MP0005408_hypopigmentation2.48577320
11MP0008877_abnormal_DNA_methylation2.43036966
12MP0000569_abnormal_digit_pigmentation2.36609623
13MP0003763_abnormal_thymus_physiology2.07680260
14MP0004272_abnormal_basement_membrane2.05930298
15MP0003121_genomic_imprinting2.04644388
16MP0000383_abnormal_hair_follicle2.02801750
17MP0004043_abnormal_pH_regulation2.00225065
18MP0000537_abnormal_urethra_morphology1.99756483
19MP0003646_muscle_fatigue1.99674980
20MP0005275_abnormal_skin_tensile1.96429324
21MP0010678_abnormal_skin_adnexa1.94608867
22MP0002009_preneoplasia1.93378751
23MP0005248_abnormal_Harderian_gland1.91318328
24MP0000371_diluted_coat_color1.89679420
25MP0008438_abnormal_cutaneous_collagen1.86654601
26MP0000778_abnormal_nervous_system1.83401632
27MP0002877_abnormal_melanocyte_morpholog1.81127943
28MP0002638_abnormal_pupillary_reflex1.74914557
29MP0003941_abnormal_skin_development1.74506614
30MP0005670_abnormal_white_adipose1.67816970
31MP0009384_cardiac_valve_regurgitation1.57432473
32MP0003045_fibrosis1.56917311
33MP0010368_abnormal_lymphatic_system1.52550818
34MP0008789_abnormal_olfactory_epithelium1.46159922
35MP0005076_abnormal_cell_differentiation1.45395032
36MP0010352_gastrointestinal_tract_polyps1.42897313
37MP0005257_abnormal_intraocular_pressure1.42532889
38MP0005666_abnormal_adipose_tissue1.41196746
39MP0003252_abnormal_bile_duct1.39967944
40MP0003300_gastrointestinal_ulcer1.39538955
41MP0010030_abnormal_orbit_morphology1.37933075
42MP0000733_abnormal_muscle_development1.34626928
43MP0008961_abnormal_basal_metabolism1.34624667
44MP0009053_abnormal_anal_canal1.34101858
45MP0005187_abnormal_penis_morphology1.33443458
46MP0000631_abnormal_neuroendocrine_gland1.32658269
47MP0001958_emphysema1.32530986
48MP0001324_abnormal_eye_pigmentation1.31925805
49MP0005394_taste/olfaction_phenotype1.31317327
50MP0005499_abnormal_olfactory_system1.31317327
51MP0003566_abnormal_cell_adhesion1.31137591
52MP0005253_abnormal_eye_physiology1.27102309
53MP0003115_abnormal_respiratory_system1.25292097
54MP0002796_impaired_skin_barrier1.22779364
55MP0002139_abnormal_hepatobiliary_system1.20814685
56MP0000427_abnormal_hair_cycle1.20140836
57MP0002060_abnormal_skin_morphology1.20020140
58MP0003136_yellow_coat_color1.15605051
59MP0010094_abnormal_chromosome_stability1.14980762
60MP0002168_other_aberrant_phenotype1.14122258
61MP0005174_abnormal_tail_pigmentation1.13482323
62MP0006054_spinal_hemorrhage1.13411814
63MP0004381_abnormal_hair_follicle1.12346980
64MP0008995_early_reproductive_senescence1.11998183
65MP0004185_abnormal_adipocyte_glucose1.11417708
66MP0001984_abnormal_olfaction1.08277086
67MP0002098_abnormal_vibrissa_morphology1.08183317
68MP0009703_decreased_birth_body1.07547475
69MP0002254_reproductive_system_inflammat1.07484808
70MP0000015_abnormal_ear_pigmentation1.06832745
71MP0002938_white_spotting1.05653974
72MP0005503_abnormal_tendon_morphology1.04704116
73MP0002233_abnormal_nose_morphology1.04649443
74MP0004130_abnormal_muscle_cell1.04531041
75MP0003195_calcinosis1.04528445
76MP0003937_abnormal_limbs/digits/tail_de1.04175788
77MP0002092_abnormal_eye_morphology1.03672063
78MP0003950_abnormal_plasma_membrane1.03298470
79MP0001286_abnormal_eye_development1.02107796
80MP0005075_abnormal_melanosome_morpholog1.01939994
81MP0003935_abnormal_craniofacial_develop1.01531198
82MP0001849_ear_inflammation0.99982495
83MP0003183_abnormal_peptide_metabolism0.99863914
84MP0002697_abnormal_eye_size0.99383044
85MP0005375_adipose_tissue_phenotype0.98192469
86MP0006138_congestive_heart_failure0.98178258
87MP0009278_abnormal_bone_marrow0.98066945
88MP0004145_abnormal_muscle_electrophysio0.97896410
89MP0001879_abnormal_lymphatic_vessel0.97680662
90MP0000377_abnormal_hair_follicle0.97624800
91MP0009780_abnormal_chondrocyte_physiolo0.96878404
92MP0000647_abnormal_sebaceous_gland0.96862945
93MP0000579_abnormal_nail_morphology0.96820271
94MP0003453_abnormal_keratinocyte_physiol0.95627807
95MP0003385_abnormal_body_wall0.92551520
96MP0003567_abnormal_fetal_cardiomyocyte0.92336936
97MP0003938_abnormal_ear_development0.91950600
98MP0004264_abnormal_extraembryonic_tissu0.91120489
99MP0003315_abnormal_perineum_morphology0.90766234
100MP0002166_altered_tumor_susceptibility0.89632231
101MP0004484_altered_response_of0.89311010
102MP0002127_abnormal_cardiovascular_syste0.89298730
103MP0004084_abnormal_cardiac_muscle0.88298771
104MP0000566_synostosis0.87808414
105MP0005310_abnormal_salivary_gland0.87780134
106MP0001293_anophthalmia0.87223883
107MP0004142_abnormal_muscle_tone0.87059474
108MP0010630_abnormal_cardiac_muscle0.86582277
109MP0005360_urolithiasis0.86475942
110MP0001661_extended_life_span0.86398063
111MP0000467_abnormal_esophagus_morphology0.86392541
112MP0003890_abnormal_embryonic-extraembry0.85689253
113MP0005365_abnormal_bile_salt0.85440329
114MP0000428_abnormal_craniofacial_morphol0.85349320
115MP0002075_abnormal_coat/hair_pigmentati0.85259108
116MP0002653_abnormal_ependyma_morphology0.85138067
117MP0002138_abnormal_hepatobiliary_system0.83849288
118MP0003122_maternal_imprinting0.83535538
119MP0010307_abnormal_tumor_latency0.83450986
120MP0005623_abnormal_meninges_morphology0.82588277
121MP0005551_abnormal_eye_electrophysiolog0.81922999
122MP0005023_abnormal_wound_healing0.80839606
123MP0002928_abnormal_bile_duct0.80669727
124MP0000432_abnormal_head_morphology0.79480212
125MP0002108_abnormal_muscle_morphology0.79436138
126MP0003943_abnormal_hepatobiliary_system0.79348413
127MP0004197_abnormal_fetal_growth/weight/0.79066235
128MP0005391_vision/eye_phenotype0.78141489
129MP0005266_abnormal_metabolism0.77950163
130MP0005395_other_phenotype0.77927311
131MP0006072_abnormal_retinal_apoptosis0.77774529
132MP0003632_abnormal_nervous_system0.77663822
133MP0005195_abnormal_posterior_eye0.77627857
134MP0003861_abnormal_nervous_system0.77134957
135MP0000534_abnormal_ureter_morphology0.76874875
136MP0005409_darkened_coat_color0.76763428
137MP0001299_abnormal_eye_distance/0.76642779
138MP0002084_abnormal_developmental_patter0.76120310
139MP0002925_abnormal_cardiovascular_devel0.75681782
140MP0000762_abnormal_tongue_morphology0.75290675
141MP0000003_abnormal_adipose_tissue0.74994838
142MP0002095_abnormal_skin_pigmentation0.74989546
143MP0000767_abnormal_smooth_muscle0.74895350
144MP0003942_abnormal_urinary_system0.73301337
145MP0002234_abnormal_pharynx_morphology0.73201283
146MP0003755_abnormal_palate_morphology0.72529835
147MP0004134_abnormal_chest_morphology0.70705358
148MP0005386_behavior/neurological_phenoty0.69880373
149MP0004924_abnormal_behavior0.69880373
150MP0001346_abnormal_lacrimal_gland0.69765901
151MP0000703_abnormal_thymus_morphology0.68283619
152MP0002088_abnormal_embryonic_growth/wei0.68265050
153MP0002109_abnormal_limb_morphology0.65729557
154MP0009115_abnormal_fat_cell0.63671161
155MP0001784_abnormal_fluid_regulation0.61775884
156MP0005389_reproductive_system_phenotype0.61217123
157MP0002177_abnormal_outer_ear0.60376895
158MP0003936_abnormal_reproductive_system0.60077340
159MP0001177_atelectasis0.59813059
160MP0003984_embryonic_growth_retardation0.59565492

Predicted human phenotypes

RankGene SetZ-score
1Subacute progressive viral hepatitis (HP:0006572)3.81928766
2Chronic hepatic failure (HP:0100626)3.52105833
3Genetic anticipation (HP:0003743)3.36295069
4Short 4th metacarpal (HP:0010044)3.26047439
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.26047439
6Rectal prolapse (HP:0002035)3.09813786
7Aplasia/Hypoplasia of the macula (HP:0008059)2.93707987
8Abnormality of the fingertips (HP:0001211)2.91775750
9Hyperventilation (HP:0002883)2.81336991
10Aortic aneurysm (HP:0004942)2.80841020
11Right ventricular cardiomyopathy (HP:0011663)2.79024815
12Chorioretinal atrophy (HP:0000533)2.77785943
13Aplasia/Hypoplasia affecting the retina (HP:0008061)2.75988642
14Pigmentary retinal degeneration (HP:0001146)2.75194810
15Pancreatic cysts (HP:0001737)2.74107728
16Cerebral aneurysm (HP:0004944)2.72814351
17Abnormality of the 4th metacarpal (HP:0010012)2.66336487
18Tubulointerstitial nephritis (HP:0001970)2.65843771
19Hypopigmentation of the fundus (HP:0007894)2.65615774
20Lip pit (HP:0100267)2.61005702
21True hermaphroditism (HP:0010459)2.57180360
22Ankle contracture (HP:0006466)2.57059552
23Abnormality of the renal medulla (HP:0100957)2.56856603
24Oligodactyly (hands) (HP:0001180)2.54856895
25Hypoplasia of the iris (HP:0007676)2.54813555
26Macroorchidism (HP:0000053)2.54245112
27Thyroiditis (HP:0100646)2.49776687
28Lymphangioma (HP:0100764)2.45488261
29Pancreatic fibrosis (HP:0100732)2.43979702
30Abnormal ciliary motility (HP:0012262)2.43794289
31Increased connective tissue (HP:0009025)2.42332257
32T lymphocytopenia (HP:0005403)2.37852151
33Shallow orbits (HP:0000586)2.35309642
34Tented upper lip vermilion (HP:0010804)2.33525843
35Hematochezia (HP:0002573)2.33187033
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.30718593
37Abnormality of the renal cortex (HP:0011035)2.30344428
38Papillary thyroid carcinoma (HP:0002895)2.30183973
39Blue irides (HP:0000635)2.29991317
40Abnormality of chromosome stability (HP:0003220)2.29520036
41Nephronophthisis (HP:0000090)2.29374076
42Ectopic kidney (HP:0000086)2.29112193
43Dynein arm defect of respiratory motile cilia (HP:0012255)2.28992385
44Absent/shortened dynein arms (HP:0200106)2.28992385
45Chromsome breakage (HP:0040012)2.27691982
46Hyperkalemia (HP:0002153)2.27139387
47Germ cell neoplasia (HP:0100728)2.26006950
48Gaze-evoked nystagmus (HP:0000640)2.23311965
49Atrophic scars (HP:0001075)2.21627238
50Cystic liver disease (HP:0006706)2.21443840
51Aqueductal stenosis (HP:0002410)2.20076939
52Abnormal respiratory motile cilium physiology (HP:0012261)2.19874741
53Rhinitis (HP:0012384)2.19377854
54Milia (HP:0001056)2.18839264
55Chromosomal breakage induced by crosslinking agents (HP:0003221)2.14918356
56Hyperactive renin-angiotensin system (HP:0000841)2.14369544
57Aneurysm (HP:0002617)2.13560703
58Abnormality of midbrain morphology (HP:0002418)2.13290716
59Molar tooth sign on MRI (HP:0002419)2.13290716
60Progressive cerebellar ataxia (HP:0002073)2.11583761
61Hyporeflexia of lower limbs (HP:0002600)2.10138367
62Bronchiectasis (HP:0002110)2.09515979
63Renovascular hypertension (HP:0100817)2.07931731
64Abnormality of T cell number (HP:0011839)2.06711178
65Abnormal respiratory motile cilium morphology (HP:0005938)2.06541649
66Abnormal respiratory epithelium morphology (HP:0012253)2.06541649
67Elfin facies (HP:0004428)2.06207417
68Midline defect of the nose (HP:0004122)2.05376928
69High anterior hairline (HP:0009890)2.01233165
70Aplasia/Hypoplasia of the fovea (HP:0008060)2.00981112
71Hypoplasia of the fovea (HP:0007750)2.00981112
72Subcapsular cataract (HP:0000523)1.99600346
73Abnormality of chloride homeostasis (HP:0011422)1.99445129
74Postaxial foot polydactyly (HP:0001830)1.98923561
75Fair hair (HP:0002286)1.98281801
76Narrow palate (HP:0000189)1.98074711
77Advanced eruption of teeth (HP:0006288)1.97311983
78Enlarged penis (HP:0000040)1.96617612
79Aplasia/Hypoplasia of the sternum (HP:0006714)1.96559864
80Male infertility (HP:0003251)1.96133100
81Widely spaced teeth (HP:0000687)1.95939576
82Shawl scrotum (HP:0000049)1.94360014
83Mitral valve prolapse (HP:0001634)1.94265276
84Aortic dissection (HP:0002647)1.93359112
85Hypoplastic labia majora (HP:0000059)1.93281409
86Abnormality of the nasal septum (HP:0000419)1.92756609
87Tubular atrophy (HP:0000092)1.92527780
88Congenital sensorineural hearing impairment (HP:0008527)1.92430907
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.91141046
90Micronodular cirrhosis (HP:0001413)1.91061616
91Prominent nose (HP:0000448)1.89275607
92Skull defect (HP:0001362)1.86970406
93Long clavicles (HP:0000890)1.86749971
94Poor coordination (HP:0002370)1.86332000
95Hypoplastic ischia (HP:0003175)1.85661247
96Osteolytic defects of the phalanges of the hand (HP:0009771)1.84417227
97Osteolytic defects of the hand bones (HP:0009699)1.84417227
98Abnormality of the aortic arch (HP:0012303)1.82947323
99Intestinal atresia (HP:0011100)1.81487813
100Hepatocellular carcinoma (HP:0001402)1.80903829
101Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.80750926
102Labial hypoplasia (HP:0000066)1.80454613
103Protruding tongue (HP:0010808)1.80247613
104Thin bony cortex (HP:0002753)1.80107721
105Rhabdomyosarcoma (HP:0002859)1.78866591
106Thyroid-stimulating hormone excess (HP:0002925)1.78849173
107Hip dysplasia (HP:0001385)1.78345681
108Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.76834437
109Increased circulating renin level (HP:0000848)1.76038053
110Gonadotropin excess (HP:0000837)1.75945908
111Long toe (HP:0010511)1.75277840
112Thick eyebrow (HP:0000574)1.73839234
113Cystic hygroma (HP:0000476)1.73667590
114Renal hypoplasia (HP:0000089)1.73395380
115Neoplasm of striated muscle (HP:0009728)1.73072657
116Esophageal varix (HP:0002040)1.72600427
117Facial hemangioma (HP:0000329)1.72572899
118Abnormality of the fovea (HP:0000493)1.72292961
119Truncal obesity (HP:0001956)1.71840821
120Hypoplastic iliac wings (HP:0002866)1.71773522
121Absent frontal sinuses (HP:0002688)1.70992966
122Thyroid carcinoma (HP:0002890)1.70821361
123Abnormality of the astrocytes (HP:0100707)1.70763925
124Astrocytoma (HP:0009592)1.70763925
125Recurrent bronchitis (HP:0002837)1.70739293
126Cortical dysplasia (HP:0002539)1.70473040
127Protrusio acetabuli (HP:0003179)1.69898896
128Difficulty running (HP:0009046)1.69323621
129Abnormal pancreas size (HP:0012094)1.69211966
130Congenital hepatic fibrosis (HP:0002612)1.69002643
131Drooling (HP:0002307)1.68942241
132Bronchitis (HP:0012387)1.68597583
133Volvulus (HP:0002580)1.68444082
134Oligodactyly (HP:0012165)1.68381404
135Bladder diverticulum (HP:0000015)1.68365262
136Vitreoretinal degeneration (HP:0000655)1.68118378
137Broad metatarsal (HP:0001783)1.68018236
138Heterotopia (HP:0002282)1.67165403
139Medial flaring of the eyebrow (HP:0010747)1.66976898
140Abnormality of the ischium (HP:0003174)1.66217294
141Chronic bronchitis (HP:0004469)1.65482370
142Abnormality of the labia majora (HP:0012881)1.65043881
143Natal tooth (HP:0000695)1.64584690
144Highly arched eyebrow (HP:0002553)1.64561115
145Cupped ear (HP:0000378)1.64296256
146Clubbing of toes (HP:0100760)1.64252999
147Tubulointerstitial abnormality (HP:0001969)1.63921525
148Hepatoblastoma (HP:0002884)1.63378515
149Neonatal death (HP:0003811)1.61931058
150Hyperacusis (HP:0010780)1.60982473
151Excessive salivation (HP:0003781)1.60574272
152Abnormality of incisor morphology (HP:0011063)1.59966520
153Down-sloping shoulders (HP:0200021)1.59834159
154Malignant gastrointestinal tract tumors (HP:0006749)1.59481769
155Gastrointestinal carcinoma (HP:0002672)1.59481769
156Long eyelashes (HP:0000527)1.58181438
157Ureteral obstruction (HP:0006000)1.58148618
158Alopecia of scalp (HP:0002293)1.57135079
159Viral hepatitis (HP:0006562)1.56698227
160Laryngomalacia (HP:0001601)1.55905659
161Scapular winging (HP:0003691)1.55881509
162Acanthosis nigricans (HP:0000956)1.54638038
163Sandal gap (HP:0001852)1.54387454
164Bicornuate uterus (HP:0000813)1.52791670
165Facial shape deformation (HP:0011334)1.52572253
166Potter facies (HP:0002009)1.52572253
167Hypoalphalipoproteinemia (HP:0003233)1.52270922
168Abnormality of the gastric mucosa (HP:0004295)1.51470319
169Bony spicule pigmentary retinopathy (HP:0007737)1.50835705
170Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.48013730
171Supernumerary ribs (HP:0005815)1.46150856
172Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.46083652
173Biliary tract neoplasm (HP:0100574)1.45962933
174Overgrowth (HP:0001548)1.45863942
175Abnormality of the epiphyses of the hand (HP:0005924)1.45121133
176Portal hypertension (HP:0001409)1.42062485
177Hand muscle atrophy (HP:0009130)1.40041168
178Bell-shaped thorax (HP:0001591)1.39975017
179Renal duplication (HP:0000075)1.39111025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.80352340
2MST1R4.43245935
3TRIB32.94630267
4CAMK1D2.67053888
5CDK122.55814930
6RIPK12.51811889
7NLK2.46456322
8ACVR1B2.31877226
9MET2.16957940
10TTN2.16317137
11CAMK1G2.02512115
12PKN22.01598677
13BMPR1B1.89877387
14SIK11.84990546
15EPHB21.84180399
16PTK61.82081336
17STK31.79902678
18PDGFRA1.77322393
19FRK1.75624701
20AKT31.75065780
21DDR21.62915932
22FER1.60862090
23LMTK21.52073833
24TNIK1.46096714
25FGFR21.45222186
26CDK61.44488381
27NUAK11.43998172
28STK38L1.41756997
29MAP3K101.40540629
30EPHA41.40431430
31MAPK131.32992600
32FGFR31.32500481
33MAP3K41.28443358
34EEF2K1.28160607
35BMX1.27920558
36MTOR1.26496518
37BRSK21.26075729
38DMPK1.24922137
39MARK21.24147959
40CASK1.22370291
41OXSR11.20964413
42TAOK31.16181010
43NEK21.14956395
44BRD41.14376991
45WNK41.13840588
46PIK3CG1.13388508
47CDC71.12760902
48IRAK11.12526690
49INSRR1.09003032
50WNK31.05465746
51CDK91.03184331
52ERBB20.98857308
53FGFR40.98217947
54PDGFRB0.97308458
55NEK60.96752525
56TIE10.96508484
57EPHA30.96216380
58MAPK150.96027500
59MKNK20.95278118
60TEC0.94448971
61DYRK1B0.92793306
62FGFR10.92585799
63PNCK0.91492805
64CAMK40.89326807
65CAMKK20.87977722
66STK110.86238472
67MELK0.84877800
68PDK40.84397196
69PDK30.84397196
70MARK30.84227981
71PTK2B0.83715392
72ZAK0.83356484
73SGK30.82942693
74SGK10.82590071
75ERBB30.82424292
76TXK0.82400522
77JAK10.81907983
78TRPM70.80644180
79BTK0.78744146
80TYRO30.78727460
81PRKAA20.77894236
82NEK90.77777455
83PTK20.75461002
84DYRK1A0.75279138
85SGK20.75193177
86TGFBR20.74823419
87PAK20.73868941
88CDK40.72130114
89WNK10.71870939
90MARK10.71496858
91YES10.71006734
92GSK3A0.70090994
93NTRK20.69523079
94TTK0.69478527
95BLK0.69030291
96LATS20.68903556
97RPS6KB20.67424428
98CHUK0.67367257
99MAP3K20.66565009
100PRKD30.65791837
101PRKAA10.64999086
102MAP3K30.64979491
103PAK40.64724018
104LRRK20.63810958
105IKBKE0.62515927
106TGFBR10.60971280
107STK100.60969428
108RPS6KA40.58709949
109AURKB0.58070863
110CSK0.56943182
111ICK0.56711437
112RET0.55780446
113CDK30.55678195
114STK40.53208189
115ATM0.52555681
116ITK0.51876888
117BCR0.51803817
118RPS6KB10.51552059
119STK390.50367967
120CDK70.50101333
121MAP3K70.50061460
122ROCK10.49893809
123OBSCN0.49446874
124MYLK0.49413697
125CDC42BPA0.48969837
126PAK30.48632205
127CSNK1D0.48450077
128ATR0.47892032
129EPHA20.47326632
130CSNK1A1L0.47036179
131PDK20.45414253
132NTRK30.44697094
133SGK2230.44405547
134SGK4940.44405547
135CHEK10.43080894
136CHEK20.42547046
137AKT20.41872183
138AKT10.41011450
139STK380.39863977
140CAMK10.39582190
141PKN10.37284076
142MAPKAPK30.36940365
143KSR10.36353379
144CAMKK10.35779265
145PIK3CA0.35746777
146GRK10.35591968
147MAPK100.35529646
148STK240.35081530
149MKNK10.34861873

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.52803275
2Adherens junction_Homo sapiens_hsa045202.34161459
3Non-homologous end-joining_Homo sapiens_hsa034502.09431403
4ECM-receptor interaction_Homo sapiens_hsa045122.08755829
5Fanconi anemia pathway_Homo sapiens_hsa034602.02534160
6Small cell lung cancer_Homo sapiens_hsa052221.90762817
7Fatty acid biosynthesis_Homo sapiens_hsa000611.88461957
8Fatty acid degradation_Homo sapiens_hsa000711.83684819
9PPAR signaling pathway_Homo sapiens_hsa033201.75680863
10Phototransduction_Homo sapiens_hsa047441.71057333
11Basal cell carcinoma_Homo sapiens_hsa052171.68229068
12Fatty acid metabolism_Homo sapiens_hsa012121.67583231
13Focal adhesion_Homo sapiens_hsa045101.65422731
14Propanoate metabolism_Homo sapiens_hsa006401.51709650
15MicroRNAs in cancer_Homo sapiens_hsa052061.51547710
16Hippo signaling pathway_Homo sapiens_hsa043901.51008064
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.50625898
18Phosphatidylinositol signaling system_Homo sapiens_hsa040701.50363842
19Tyrosine metabolism_Homo sapiens_hsa003501.48280531
20Non-small cell lung cancer_Homo sapiens_hsa052231.46007165
21Insulin resistance_Homo sapiens_hsa049311.44255720
22TGF-beta signaling pathway_Homo sapiens_hsa043501.43620679
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.40611477
24Proteoglycans in cancer_Homo sapiens_hsa052051.37963165
25Dorso-ventral axis formation_Homo sapiens_hsa043201.36879489
26Notch signaling pathway_Homo sapiens_hsa043301.35396235
27Protein digestion and absorption_Homo sapiens_hsa049741.35179300
28T cell receptor signaling pathway_Homo sapiens_hsa046601.31104237
29Tight junction_Homo sapiens_hsa045301.29186083
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26852872
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22941637
32Ovarian steroidogenesis_Homo sapiens_hsa049131.18311165
33Choline metabolism in cancer_Homo sapiens_hsa052311.17898075
34AMPK signaling pathway_Homo sapiens_hsa041521.15954710
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.14020552
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.12563045
37Endometrial cancer_Homo sapiens_hsa052131.08949656
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08767489
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.07847765
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07470304
41Amoebiasis_Homo sapiens_hsa051461.06356856
42Fat digestion and absorption_Homo sapiens_hsa049751.06032031
43Selenocompound metabolism_Homo sapiens_hsa004501.05697769
44Hedgehog signaling pathway_Homo sapiens_hsa043401.05189876
45Taste transduction_Homo sapiens_hsa047421.02486885
46Chronic myeloid leukemia_Homo sapiens_hsa052201.00831037
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00698425
48Viral myocarditis_Homo sapiens_hsa054160.99331313
49Linoleic acid metabolism_Homo sapiens_hsa005910.99282335
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99261841
51ABC transporters_Homo sapiens_hsa020100.98806887
52Prostate cancer_Homo sapiens_hsa052150.98505996
53Caffeine metabolism_Homo sapiens_hsa002320.98451874
54Glioma_Homo sapiens_hsa052140.97263004
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96783288
56Starch and sucrose metabolism_Homo sapiens_hsa005000.96375488
57Primary immunodeficiency_Homo sapiens_hsa053400.95027471
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92722025
59mTOR signaling pathway_Homo sapiens_hsa041500.92206120
60B cell receptor signaling pathway_Homo sapiens_hsa046620.90369208
61Vitamin digestion and absorption_Homo sapiens_hsa049770.90345059
62Dilated cardiomyopathy_Homo sapiens_hsa054140.89580544
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89368244
64Glucagon signaling pathway_Homo sapiens_hsa049220.87637335
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86664053
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86504538
67Tryptophan metabolism_Homo sapiens_hsa003800.85343534
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84679022
69Homologous recombination_Homo sapiens_hsa034400.84555692
70Glycerolipid metabolism_Homo sapiens_hsa005610.84366631
71Renal cell carcinoma_Homo sapiens_hsa052110.84024870
72Nitrogen metabolism_Homo sapiens_hsa009100.83972008
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83715165
74FoxO signaling pathway_Homo sapiens_hsa040680.82761735
75ErbB signaling pathway_Homo sapiens_hsa040120.81850543
76Cholinergic synapse_Homo sapiens_hsa047250.81646635
77Melanogenesis_Homo sapiens_hsa049160.81357215
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80919336
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80388854
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80356164
81Insulin signaling pathway_Homo sapiens_hsa049100.80339582
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.79691645
83Thyroid cancer_Homo sapiens_hsa052160.79238392
84Bile secretion_Homo sapiens_hsa049760.79090114
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78846796
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78469111
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.77829356
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77615801
89Pathways in cancer_Homo sapiens_hsa052000.76497785
90Toxoplasmosis_Homo sapiens_hsa051450.76346238
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76085803
92Pyruvate metabolism_Homo sapiens_hsa006200.75779123
93Pancreatic cancer_Homo sapiens_hsa052120.75023401
94Circadian rhythm_Homo sapiens_hsa047100.74347030
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74061257
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72925462
97Retinol metabolism_Homo sapiens_hsa008300.72785878
98cAMP signaling pathway_Homo sapiens_hsa040240.72442089
99Mineral absorption_Homo sapiens_hsa049780.72222923
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.71832824
101Cell cycle_Homo sapiens_hsa041100.71739095
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71469457
103Measles_Homo sapiens_hsa051620.71359144
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70981376
105Wnt signaling pathway_Homo sapiens_hsa043100.69021063
106Platelet activation_Homo sapiens_hsa046110.68645635
107Complement and coagulation cascades_Homo sapiens_hsa046100.68603549
108Long-term depression_Homo sapiens_hsa047300.68146768
109Type II diabetes mellitus_Homo sapiens_hsa049300.67982719
110Prolactin signaling pathway_Homo sapiens_hsa049170.66595577
111Butanoate metabolism_Homo sapiens_hsa006500.66000867
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.65805304
113HTLV-I infection_Homo sapiens_hsa051660.64872667
114Oxytocin signaling pathway_Homo sapiens_hsa049210.62380613
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62347802
116Colorectal cancer_Homo sapiens_hsa052100.61512152
117Systemic lupus erythematosus_Homo sapiens_hsa053220.60910372
118Melanoma_Homo sapiens_hsa052180.59652415
119Renin secretion_Homo sapiens_hsa049240.58953459
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58879326
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58556488
122Axon guidance_Homo sapiens_hsa043600.58504353
123Ras signaling pathway_Homo sapiens_hsa040140.58386616
124Hepatitis B_Homo sapiens_hsa051610.57738552
125Renin-angiotensin system_Homo sapiens_hsa046140.57494573
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57210765
127Bladder cancer_Homo sapiens_hsa052190.56853090
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.56116260
129Olfactory transduction_Homo sapiens_hsa047400.55818296
130Basal transcription factors_Homo sapiens_hsa030220.54661272
131Calcium signaling pathway_Homo sapiens_hsa040200.54562000
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54197087
133Histidine metabolism_Homo sapiens_hsa003400.53364479
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53273619
135Regulation of autophagy_Homo sapiens_hsa041400.53081418
136Primary bile acid biosynthesis_Homo sapiens_hsa001200.52821233
137Inositol phosphate metabolism_Homo sapiens_hsa005620.52509215
138Maturity onset diabetes of the young_Homo sapiens_hsa049500.52491961
139Glutamatergic synapse_Homo sapiens_hsa047240.51046801
140RNA degradation_Homo sapiens_hsa030180.50686526
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50378075
142Arginine biosynthesis_Homo sapiens_hsa002200.50258177
143Salivary secretion_Homo sapiens_hsa049700.49738867
144Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49539797
145Hepatitis C_Homo sapiens_hsa051600.49449770
146beta-Alanine metabolism_Homo sapiens_hsa004100.49271922
147Estrogen signaling pathway_Homo sapiens_hsa049150.48993971
148mRNA surveillance pathway_Homo sapiens_hsa030150.48912369

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