SYNC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and cardiac muscle. The protein links the dystrophin associated protein complex (DAPC) to desmin filaments in muscle and may have a structural role in striated muscle. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)8.30696885
2actin-myosin filament sliding (GO:0033275)8.30696885
3plasma membrane repair (GO:0001778)7.24400188
4actin-mediated cell contraction (GO:0070252)7.07347070
5sarcomere organization (GO:0045214)6.97871521
6sarcoplasmic reticulum calcium ion transport (GO:0070296)6.94582734
7regulation of skeletal muscle contraction (GO:0014819)6.73837113
8skeletal muscle contraction (GO:0003009)6.68102746
9response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.14280287
10negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.67747859
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.64299097
12myofibril assembly (GO:0030239)5.54855136
13actin filament-based movement (GO:0030048)5.14621854
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.09108787
15regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.02482719
16negative regulation of protein localization to cell surface (GO:2000009)5.00318926
17regulation of cell communication by electrical coupling (GO:0010649)4.90963927
18cardiac myofibril assembly (GO:0055003)4.88369985
19regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.86244510
20striated muscle contraction (GO:0006941)4.81858638
21regulation of relaxation of muscle (GO:1901077)4.76823397
22negative regulation of potassium ion transmembrane transport (GO:1901380)4.72015759
23actomyosin structure organization (GO:0031032)4.51747521
24creatine metabolic process (GO:0006600)4.44454542
25response to inactivity (GO:0014854)4.40357915
26parental behavior (GO:0060746)4.37292958
27muscle cell fate commitment (GO:0042693)4.27678395
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.24752759
29regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.16163770
30respiratory electron transport chain (GO:0022904)4.10037722
31cardiac muscle cell development (GO:0055013)4.09809821
32regulation of striated muscle contraction (GO:0006942)4.09321749
33regulation of actin filament-based movement (GO:1903115)4.08618629
34muscle contraction (GO:0006936)4.05161963
35cardiac muscle contraction (GO:0060048)4.03503608
36maternal behavior (GO:0042711)4.01014233
37electron transport chain (GO:0022900)3.97555328
38regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.90329260
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.87226537
40ATP synthesis coupled proton transport (GO:0015986)3.87226537
41skeletal muscle fiber development (GO:0048741)3.86087465
42cardiac cell development (GO:0055006)3.76376902
43ventricular cardiac muscle cell action potential (GO:0086005)3.74317080
44adult heart development (GO:0007512)3.70982826
45cardiac muscle tissue morphogenesis (GO:0055008)3.67005689
46regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.62210903
47muscle system process (GO:0003012)3.61577486
48muscle tissue morphogenesis (GO:0060415)3.59779320
49negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.58389962
50ubiquinone metabolic process (GO:0006743)3.57205360
51positive regulation of action potential (GO:0045760)3.54180579
52muscle structure development (GO:0061061)3.52352188
53myoblast fusion (GO:0007520)3.52122731
54regulation of sarcomere organization (GO:0060297)3.50288259
55neuron remodeling (GO:0016322)3.48697938
56muscle fiber development (GO:0048747)3.47543840
57muscle organ development (GO:0007517)3.46713248
58regulation of membrane repolarization (GO:0060306)3.45612518
59ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.35609252
60sequestering of extracellular ligand from receptor (GO:0035581)3.33240087
61myotube cell development (GO:0014904)3.33185821
62regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.32453346
63skeletal muscle tissue regeneration (GO:0043403)3.32040125
64negative regulation of muscle hypertrophy (GO:0014741)3.31331422
65skeletal muscle adaptation (GO:0043501)3.31224291
66striated muscle cell development (GO:0055002)3.30491265
67collagen fibril organization (GO:0030199)3.29553799
68muscle cell cellular homeostasis (GO:0046716)3.27535679
69axon ensheathment in central nervous system (GO:0032291)3.25197828
70central nervous system myelination (GO:0022010)3.25197828
71bundle of His cell to Purkinje myocyte communication (GO:0086069)3.24292473
72regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.21513648
73striated muscle atrophy (GO:0014891)3.20264087
74syncytium formation (GO:0006949)3.18065137
75positive regulation of cardiac muscle cell differentiation (GO:2000727)3.16975734
76protein heterotrimerization (GO:0070208)3.14816958
77regulation of cardiac muscle contraction (GO:0055117)3.14119830
78regulation of acyl-CoA biosynthetic process (GO:0050812)3.11914304
79positive regulation of microtubule polymerization (GO:0031116)3.10369474
80metanephric mesenchyme development (GO:0072075)3.10368727
81kidney mesenchyme development (GO:0072074)3.09539385
82response to muscle activity (GO:0014850)3.09452629
83negative regulation of axon extension involved in axon guidance (GO:0048843)3.09450500
84regulation of calcium ion transmembrane transporter activity (GO:1901019)3.07795568
85regulation of calcium ion transmembrane transport (GO:1903169)3.07795568
86regulation of action potential (GO:0098900)3.03444072
87syncytium formation by plasma membrane fusion (GO:0000768)2.99178167
88chondrocyte proliferation (GO:0035988)2.96666201
89detection of calcium ion (GO:0005513)2.96011024
90negative regulation of cardiac muscle hypertrophy (GO:0010614)2.95551476
91positive regulation of myotube differentiation (GO:0010831)2.95069084
92regulation of integrin-mediated signaling pathway (GO:2001044)2.94507278
93regulation of muscle contraction (GO:0006937)2.94317494
94muscle atrophy (GO:0014889)2.87861174
95skeletal muscle tissue development (GO:0007519)2.86134248
96negative regulation of axon guidance (GO:1902668)2.86084352
97developmental pigmentation (GO:0048066)2.84215534
98positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.83700493
99positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.83700493
100positive regulation of mitotic sister chromatid separation (GO:1901970)2.83700493
101somite development (GO:0061053)2.83155993
102limb bud formation (GO:0060174)2.82117843
103muscle cell development (GO:0055001)2.81572003
104lens fiber cell differentiation (GO:0070306)2.80955659
105heart process (GO:0003015)2.78484440
106heart contraction (GO:0060047)2.78484440
107neuronal action potential (GO:0019228)2.78274783
108regulation of hexokinase activity (GO:1903299)2.77522037
109regulation of glucokinase activity (GO:0033131)2.77522037
110positive regulation of skeletal muscle tissue development (GO:0048643)2.77473210
111multicellular organismal movement (GO:0050879)2.77302601
112musculoskeletal movement (GO:0050881)2.77302601
113positive regulation of protein autophosphorylation (GO:0031954)2.75519895
114cardiac muscle hypertrophy (GO:0003300)2.74649676
115heart trabecula formation (GO:0060347)2.74539134
116detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.74372869
117striated muscle adaptation (GO:0014888)2.73644656
118cytidine metabolic process (GO:0046087)2.73033335
119cytidine catabolic process (GO:0006216)2.73033335
120cytidine deamination (GO:0009972)2.73033335
121regulation of skeletal muscle cell differentiation (GO:2001014)2.71240352
122regulation of muscle system process (GO:0090257)2.70507055
123regulation of coenzyme metabolic process (GO:0051196)2.70480394
124regulation of cofactor metabolic process (GO:0051193)2.70480394
125positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.68635370
126regulation of ATP catabolic process (GO:1903289)2.68324319
127regulation of ATPase activity (GO:0043462)2.68324319
128response to pheromone (GO:0019236)2.66012545
129inner ear receptor cell development (GO:0060119)2.64451073
130regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.64318432
131type B pancreatic cell proliferation (GO:0044342)2.62675968
132otic vesicle formation (GO:0030916)2.59665699
133negative regulation of nitric-oxide synthase activity (GO:0051001)2.58418897
134outer ear morphogenesis (GO:0042473)2.56906348
135myoblast migration (GO:0051451)2.49153065
136acrosome reaction (GO:0007340)2.47518775
137inositol phosphate catabolic process (GO:0071545)2.46735368
138myelin assembly (GO:0032288)2.44584214
139regulation of pigment cell differentiation (GO:0050932)2.43014822
140replication fork processing (GO:0031297)2.42596341
141negative regulation of activin receptor signaling pathway (GO:0032926)2.41917669
142positive regulation of meiosis (GO:0045836)2.41461731
143lipid particle organization (GO:0034389)2.41025872
144response to nitrosative stress (GO:0051409)2.40949060
145protein complex biogenesis (GO:0070271)2.40333406
146myoblast differentiation (GO:0045445)2.37168554
147DNA deamination (GO:0045006)2.36804319
148mesenchymal-epithelial cell signaling (GO:0060638)2.34901950
149regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.34286357
150DNA double-strand break processing (GO:0000729)2.34125793
151regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.33439069
152kidney morphogenesis (GO:0060993)2.33390324
153ventricular cardiac muscle cell development (GO:0055015)2.29893888
154blood vessel maturation (GO:0001955)2.28799473
155cytochrome complex assembly (GO:0017004)2.27528967
156proteasome assembly (GO:0043248)2.27072850
157cellular response to vitamin (GO:0071295)2.26427666
158peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.25029046
159regulation of cardiac muscle cell differentiation (GO:2000725)2.24060992
160adenosine metabolic process (GO:0046085)2.23320967
161extracellular regulation of signal transduction (GO:1900115)2.21966029
162extracellular negative regulation of signal transduction (GO:1900116)2.21966029

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.22907696
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.04872838
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.79515381
4VDR_22108803_ChIP-Seq_LS180_Human2.74565681
5EP300_21415370_ChIP-Seq_HL-1_Mouse2.74109120
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.55981218
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.49267448
8CDX2_19796622_ChIP-Seq_MESCs_Mouse2.48193577
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.38371997
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37573300
11FUS_26573619_Chip-Seq_HEK293_Human2.30254673
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.29018403
13MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.23521876
14GBX2_23144817_ChIP-Seq_PC3_Human2.05426972
15EWS_26573619_Chip-Seq_HEK293_Human2.01889615
16P300_19829295_ChIP-Seq_ESCs_Human1.99902451
17* EZH2_27304074_Chip-Seq_ESCs_Mouse1.98395013
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95462737
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.93672413
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90880829
21CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.80396465
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78750039
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77469431
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77469431
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.75131138
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.74645209
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.74231631
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.72241898
29* BRD4_25478319_ChIP-Seq_HGPS_Human1.71630719
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67776446
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.65999291
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65854299
33TBX20_22080862_ChIP-Seq_HEART_Mouse1.64145504
34TBX20_22328084_ChIP-Seq_HEART_Mouse1.64145504
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.64015956
36* BCAT_22108803_ChIP-Seq_LS180_Human1.63894712
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.63071261
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60466121
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59601725
40* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.59151922
41* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.59151922
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.58754977
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56187403
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.54386293
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52782918
46CBP_20019798_ChIP-Seq_JUKART_Human1.52782918
47ZNF274_21170338_ChIP-Seq_K562_Hela1.52200953
48HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.51005649
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46735202
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46505268
51* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44756178
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44394379
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43721393
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.41609092
55TP53_18474530_ChIP-ChIP_U2OS_Human1.40838829
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39772881
57ER_23166858_ChIP-Seq_MCF-7_Human1.39447098
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38917364
59FLI1_21867929_ChIP-Seq_TH2_Mouse1.37924820
60AR_25329375_ChIP-Seq_VCAP_Human1.37270857
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35835256
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35687058
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.35355695
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32178853
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30865602
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30805756
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28909087
68STAT3_23295773_ChIP-Seq_U87_Human1.28479926
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.27819828
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.27422946
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25793578
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25302707
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25234576
74* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25215697
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25174102
76PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.25172966
77* TCF4_23295773_ChIP-Seq_U87_Human1.24845356
78SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24252471
79* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24243734
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.23911452
81TAF15_26573619_Chip-Seq_HEK293_Human1.23309370
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.22775237
83* CDX2_22108803_ChIP-Seq_LS180_Human1.21875625
84TCF4_22108803_ChIP-Seq_LS180_Human1.20177009
85TP53_16413492_ChIP-PET_HCT116_Human1.19653006
86CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.19561346
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18993616
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18968572
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18647288
90P53_22387025_ChIP-Seq_ESCs_Mouse1.18516962
91KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.16900622
92ELK1_19687146_ChIP-ChIP_HELA_Human1.16852726
93FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16763702
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15713740
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15240605
96EOMES_21245162_ChIP-Seq_HESCs_Human1.12522561
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11245990
98JUN_21703547_ChIP-Seq_K562_Human1.10975052
99SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.10778302
100GATA4_21415370_ChIP-Seq_HL-1_Mouse1.10427439
101SMAD4_21741376_ChIP-Seq_EPCs_Human1.09862963
102KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09443750
103PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08965776
104IGF1R_20145208_ChIP-Seq_DFB_Human1.08579294
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08520425
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08520425
107TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07783054
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07671659
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06275361
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.05738661
111AHR_22903824_ChIP-Seq_MCF-7_Human1.03002721
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02247626
113CRX_20693478_ChIP-Seq_RETINA_Mouse0.99200592
114POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99174499
115CTCF_27219007_Chip-Seq_Bcells_Human0.98090846
116SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97922740
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96000738
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95329914
119NFE2_27457419_Chip-Seq_LIVER_Mouse0.94802032
120OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93090995
121STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93056472
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92469978
123SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90860404
124ZNF263_19887448_ChIP-Seq_K562_Human0.90362236
125* CJUN_26792858_Chip-Seq_BT549_Human0.90183706
126NANOG_19829295_ChIP-Seq_ESCs_Human0.90116970
127SOX2_19829295_ChIP-Seq_ESCs_Human0.90116970
128SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89820713
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88897148
130TBL1_22424771_ChIP-Seq_293T_Human0.88625854
131SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88432904
132SMAD4_21799915_ChIP-Seq_A2780_Human0.87708048
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86859436
134NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86446555
135RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85667090
136EZH2_27294783_Chip-Seq_NPCs_Mouse0.85579081
137P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85437648
138CREB1_15753290_ChIP-ChIP_HEK293T_Human0.85147659
139ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84005878
140TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83573830
141EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.83292245
142ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83047213
143DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82844619
144SMAD3_21741376_ChIP-Seq_EPCs_Human0.82259192
145CBP_21632823_ChIP-Seq_H3396_Human0.81704589
146OCT4_21477851_ChIP-Seq_ESCs_Mouse0.80264282
147SOX2_21211035_ChIP-Seq_LN229_Gbm0.79619669
148OCT4_20526341_ChIP-Seq_ESCs_Human0.79193636
149NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79070087
150* PHF8_20622853_ChIP-Seq_HELA_Human0.79005736

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.56144596
2MP0000751_myopathy5.54808574
3MP0000749_muscle_degeneration5.05243078
4MP0004145_abnormal_muscle_electrophysio4.40840031
5MP0003646_muscle_fatigue4.12303583
6MP0000750_abnormal_muscle_regeneration3.59783923
7MP0004084_abnormal_cardiac_muscle3.54977034
8MP0004036_abnormal_muscle_relaxation3.47532522
9MP0009379_abnormal_foot_pigmentation3.32902766
10MP0000747_muscle_weakness3.22161799
11* MP0002106_abnormal_muscle_physiology3.09019563
12MP0004215_abnormal_myocardial_fiber2.91629663
13MP0002102_abnormal_ear_morphology2.88589736
14MP0004087_abnormal_muscle_fiber2.84896917
15MP0005330_cardiomyopathy2.81711154
16MP0000759_abnormal_skeletal_muscle2.74020756
17* MP0005369_muscle_phenotype2.67601993
18MP0002269_muscular_atrophy2.53159201
19MP0004270_analgesia2.50416062
20* MP0005620_abnormal_muscle_contractility2.42756790
21MP0003950_abnormal_plasma_membrane2.24207191
22MP0001958_emphysema2.18765250
23MP0006054_spinal_hemorrhage2.11913193
24MP0002972_abnormal_cardiac_muscle2.10156182
25MP0003137_abnormal_impulse_conducting1.97223663
26MP0002938_white_spotting1.91908326
27MP0000569_abnormal_digit_pigmentation1.91254302
28MP0005187_abnormal_penis_morphology1.91117167
29MP0005174_abnormal_tail_pigmentation1.88632981
30MP0000733_abnormal_muscle_development1.86316464
31MP0000013_abnormal_adipose_tissue1.77826816
32MP0002108_abnormal_muscle_morphology1.76942583
33MP0009780_abnormal_chondrocyte_physiolo1.75593001
34MP0010386_abnormal_urinary_bladder1.69053043
35MP0009384_cardiac_valve_regurgitation1.68557260
36MP0004134_abnormal_chest_morphology1.62764824
37MP0004484_altered_response_of1.60117835
38MP0008438_abnormal_cutaneous_collagen1.51888133
39MP0002282_abnormal_trachea_morphology1.50922741
40MP0006138_congestive_heart_failure1.48593942
41MP0004233_abnormal_muscle_weight1.46351385
42MP0008775_abnormal_heart_ventricle1.45096411
43MP0000015_abnormal_ear_pigmentation1.43771132
44MP0005385_cardiovascular_system_phenoty1.41351186
45MP0001544_abnormal_cardiovascular_syste1.41351186
46MP0004085_abnormal_heartbeat1.38687364
47MP0010630_abnormal_cardiac_muscle1.34882683
48MP0004130_abnormal_muscle_cell1.30845657
49MP0001986_abnormal_taste_sensitivity1.28526660
50MP0002734_abnormal_mechanical_nocicepti1.26954621
51MP0006276_abnormal_autonomic_nervous1.23082401
52MP0003937_abnormal_limbs/digits/tail_de1.22737338
53MP0005623_abnormal_meninges_morphology1.20737436
54MP0006036_abnormal_mitochondrial_physio1.16645629
55MP0003283_abnormal_digestive_organ1.14297947
56MP0002638_abnormal_pupillary_reflex1.14159009
57MP0005367_renal/urinary_system_phenotyp1.13980875
58MP0000516_abnormal_urinary_system1.13980875
59MP0002735_abnormal_chemical_nociception1.13917032
60MP0001529_abnormal_vocalization1.13591374
61MP0002168_other_aberrant_phenotype1.12840828
62MP0002751_abnormal_autonomic_nervous1.10787301
63MP0003828_pulmonary_edema1.09632557
64MP0003221_abnormal_cardiomyocyte_apopto1.08004307
65MP0000003_abnormal_adipose_tissue1.04626952
66MP0005595_abnormal_vascular_smooth1.04396704
67MP0002332_abnormal_exercise_endurance1.04380899
68MP0002254_reproductive_system_inflammat1.04187162
69MP0002295_abnormal_pulmonary_circulatio1.02892856
70MP0000049_abnormal_middle_ear1.00979694
71MP0001299_abnormal_eye_distance/0.99648383
72MP0010368_abnormal_lymphatic_system0.99509109
73MP0002127_abnormal_cardiovascular_syste0.96896395
74MP0000538_abnormal_urinary_bladder0.96372196
75MP0003755_abnormal_palate_morphology0.93627111
76MP0004185_abnormal_adipocyte_glucose0.93289871
77MP0003385_abnormal_body_wall0.92364935
78MP0001542_abnormal_bone_strength0.92322574
79MP0004142_abnormal_muscle_tone0.91432946
80MP0002115_abnormal_skeleton_extremities0.89559492
81MP0005275_abnormal_skin_tensile0.89188399
82MP0002177_abnormal_outer_ear0.89159283
83MP0004885_abnormal_endolymph0.87885541
84MP0000647_abnormal_sebaceous_gland0.87023756
85MP0001243_abnormal_dermal_layer0.86537067
86MP0005257_abnormal_intraocular_pressure0.85552752
87MP0000534_abnormal_ureter_morphology0.84747817
88MP0005375_adipose_tissue_phenotype0.84334203
89MP0005508_abnormal_skeleton_morphology0.83799725
90MP0008260_abnormal_autophagy0.83791914
91MP0000920_abnormal_myelination0.83150735
92MP0005171_absent_coat_pigmentation0.82711493
93MP0002876_abnormal_thyroid_physiology0.81794710
94MP0003941_abnormal_skin_development0.81339750
95MP0000762_abnormal_tongue_morphology0.79157667
96MP0002160_abnormal_reproductive_system0.78757959
97MP0002896_abnormal_bone_mineralization0.78146741
98MP0001440_abnormal_grooming_behavior0.77404900
99MP0004043_abnormal_pH_regulation0.77304831
100MP0002272_abnormal_nervous_system0.77110129
101MP0005503_abnormal_tendon_morphology0.77082045
102MP0002109_abnormal_limb_morphology0.76995099
103MP0001970_abnormal_pain_threshold0.76697327
104MP0005551_abnormal_eye_electrophysiolog0.76680808
105MP0002234_abnormal_pharynx_morphology0.75972786
106MP0003279_aneurysm0.75231297
107MP0005253_abnormal_eye_physiology0.72732126
108MP0006035_abnormal_mitochondrial_morpho0.72242626
109MP0000163_abnormal_cartilage_morphology0.72085783
110MP0000613_abnormal_salivary_gland0.71122094
111MP0003942_abnormal_urinary_system0.70072156
112MP0000428_abnormal_craniofacial_morphol0.70021595
113MP0006072_abnormal_retinal_apoptosis0.70018006
114MP0004510_myositis0.68049975
115MP0005645_abnormal_hypothalamus_physiol0.66857575
116MP0002095_abnormal_skin_pigmentation0.66316061
117MP0005395_other_phenotype0.65603831
118MP0002736_abnormal_nociception_after0.64823834
119MP0005666_abnormal_adipose_tissue0.64584579
120MP0002971_abnormal_brown_adipose0.64226055
121MP0005451_abnormal_body_composition0.62839616
122MP0004742_abnormal_vestibular_system0.62291924
123MP0001661_extended_life_span0.61449855
124MP0000230_abnormal_systemic_arterial0.60983973
125MP0001968_abnormal_touch/_nociception0.59144364
126MP0010030_abnormal_orbit_morphology0.59079809
127MP0002733_abnormal_thermal_nociception0.57667996
128MP0003045_fibrosis0.56845264
129MP0002067_abnormal_sensory_capabilities0.56418173
130MP0002184_abnormal_innervation0.55646561
131MP0000372_irregular_coat_pigmentation0.55398255
132MP0004272_abnormal_basement_membrane0.52931811
133MP0005423_abnormal_somatic_nervous0.52627011
134MP0000266_abnormal_heart_morphology0.52170995
135MP0003567_abnormal_fetal_cardiomyocyte0.51426721
136MP0003195_calcinosis0.50935433
137MP0002163_abnormal_gland_morphology0.50668296
138MP0003634_abnormal_glial_cell0.50429377
139MP0008569_lethality_at_weaning0.50087327
140MP0003880_abnormal_central_pattern0.49970692
141MP0002066_abnormal_motor_capabilities/c0.49596378
142MP0005409_darkened_coat_color0.49164178
143MP0002752_abnormal_somatic_nervous0.48177423
144MP0001485_abnormal_pinna_reflex0.48152873
145MP0001188_hyperpigmentation0.47312411
146MP0005670_abnormal_white_adipose0.46917369
147MP0000778_abnormal_nervous_system0.45653573
148MP0009250_abnormal_appendicular_skeleto0.45621618
149MP0003329_amyloid_beta_deposits0.44312961
150MP0000767_abnormal_smooth_muscle0.44040568

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber splitting (HP:0003555)6.48729641
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.46860534
3Muscle fiber inclusion bodies (HP:0100299)6.45597716
4Nemaline bodies (HP:0003798)5.79443217
5Muscle hypertrophy of the lower extremities (HP:0008968)5.62892360
6Calf muscle hypertrophy (HP:0008981)5.53376490
7Exercise-induced myalgia (HP:0003738)5.42068851
8Hyporeflexia of lower limbs (HP:0002600)5.24432539
9Type 1 muscle fiber predominance (HP:0003803)5.22106699
10Distal arthrogryposis (HP:0005684)4.88502164
11Abnormality of the calf musculature (HP:0001430)4.85977765
12EMG: myopathic abnormalities (HP:0003458)4.57387307
13Fetal akinesia sequence (HP:0001989)4.55018352
14Sudden death (HP:0001699)4.38497248
15Exercise-induced muscle cramps (HP:0003710)4.16720387
16Popliteal pterygium (HP:0009756)4.09535733
17Difficulty running (HP:0009046)4.03738201
18Round ear (HP:0100830)4.01040919
19Myopathic facies (HP:0002058)3.93449416
20Difficulty climbing stairs (HP:0003551)3.90115007
21Amniotic constriction ring (HP:0009775)3.88576701
22Abnormality of placental membranes (HP:0011409)3.88576701
23Increased connective tissue (HP:0009025)3.88304308
24Aplasia of the musculature (HP:0100854)3.84071493
25Gowers sign (HP:0003391)3.67847175
26Malignant hyperthermia (HP:0002047)3.62200498
27Areflexia of lower limbs (HP:0002522)3.50586938
28Type 2 muscle fiber atrophy (HP:0003554)3.45634803
29Myotonia (HP:0002486)3.44806826
30Calcaneovalgus deformity (HP:0001848)3.43145096
31Ventricular tachycardia (HP:0004756)3.39589140
32Abnormality of the neuromuscular junction (HP:0003398)3.38174246
33Fatigable weakness (HP:0003473)3.38174246
34Abnormality of skeletal muscle fiber size (HP:0012084)3.35730881
35Increased variability in muscle fiber diameter (HP:0003557)3.30409465
36Neck muscle weakness (HP:0000467)3.19467973
37Deformed tarsal bones (HP:0008119)3.18120352
38Muscle fiber atrophy (HP:0100295)3.10960535
39Abnormality of the left ventricular outflow tract (HP:0011103)3.10032151
40Subaortic stenosis (HP:0001682)3.10032151
41Weak cry (HP:0001612)3.07764182
42Delayed gross motor development (HP:0002194)3.01082529
43Aortic dissection (HP:0002647)2.98615907
44Ulnar deviation of the wrist (HP:0003049)2.96584227
45Aortic aneurysm (HP:0004942)2.94675662
46Absent phalangeal crease (HP:0006109)2.92559459
47Protrusio acetabuli (HP:0003179)2.90279078
48Distal lower limb amyotrophy (HP:0008944)2.85975700
49Lipoatrophy (HP:0100578)2.80025167
50Akinesia (HP:0002304)2.76505713
51Rimmed vacuoles (HP:0003805)2.74418151
52Atrial fibrillation (HP:0005110)2.68713891
53Bulbar palsy (HP:0001283)2.67907786
54Right ventricular cardiomyopathy (HP:0011663)2.61860735
55Myoglobinuria (HP:0002913)2.61309767
56Mildly elevated creatine phosphokinase (HP:0008180)2.61251541
57Mesomelia (HP:0003027)2.60141982
58Distal lower limb muscle weakness (HP:0009053)2.58592833
59Acute necrotizing encephalopathy (HP:0006965)2.56472991
60Soft skin (HP:0000977)2.56328612
61Primary atrial arrhythmia (HP:0001692)2.52692219
62Dilated cardiomyopathy (HP:0001644)2.48399880
63Testicular atrophy (HP:0000029)2.47599744
64Metaphyseal dysplasia (HP:0100255)2.45686515
65Ankle contracture (HP:0006466)2.44829573
66Syncope (HP:0001279)2.44075109
67Follicular hyperkeratosis (HP:0007502)2.43726618
68Generalized muscle weakness (HP:0003324)2.42791837
69Supraventricular tachycardia (HP:0004755)2.42609741
70Hypoplastic heart (HP:0001961)2.42383066
71Abnormal mitochondria in muscle tissue (HP:0008316)2.41325889
72Muscle stiffness (HP:0003552)2.40920217
73Pterygium (HP:0001059)2.40797057
74Bundle branch block (HP:0011710)2.40098498
75Scapular winging (HP:0003691)2.38885872
76Spinal rigidity (HP:0003306)2.38508384
77Supraventricular arrhythmia (HP:0005115)2.38174251
78Aplasia/Hypoplasia involving the musculature (HP:0001460)2.37375981
79Limited hip movement (HP:0008800)2.37134094
80Abnormal finger flexion creases (HP:0006143)2.36090222
81Easy fatigability (HP:0003388)2.34975304
82Hepatocellular necrosis (HP:0001404)2.33042085
83Pancreatic cysts (HP:0001737)2.32728126
84Foot dorsiflexor weakness (HP:0009027)2.32424500
85Mitochondrial inheritance (HP:0001427)2.32148051
86Muscular dystrophy (HP:0003560)2.31440728
87Abnormality of midbrain morphology (HP:0002418)2.28965901
88Molar tooth sign on MRI (HP:0002419)2.28965901
89True hermaphroditism (HP:0010459)2.28561196
90Pancreatic fibrosis (HP:0100732)2.26284082
91Prolonged QT interval (HP:0001657)2.26221519
92Abnormality of the foot musculature (HP:0001436)2.26160819
93Respiratory insufficiency due to muscle weakness (HP:0002747)2.25052775
94Rhabdomyolysis (HP:0003201)2.22157812
95Hip contracture (HP:0003273)2.20789445
96Keratoconus (HP:0000563)2.20523498
97Increased corneal curvature (HP:0100692)2.20523498
98Infantile muscular hypotonia (HP:0008947)2.19487807
99Hepatic necrosis (HP:0002605)2.16479418
100Premature rupture of membranes (HP:0001788)2.14470109
101Limb-girdle muscle weakness (HP:0003325)2.13301724
102Shoulder girdle muscle weakness (HP:0003547)2.13260275
103Limb-girdle muscle atrophy (HP:0003797)2.12929219
104Abnormality of the shoulder girdle musculature (HP:0001435)2.12855933
105EMG: neuropathic changes (HP:0003445)2.12597752
106Ventricular fibrillation (HP:0001663)2.12170881
107Palpitations (HP:0001962)2.12023585
108Thin ribs (HP:0000883)2.10372827
109Vascular tortuosity (HP:0004948)2.09620866
110Abnormal atrioventricular conduction (HP:0005150)2.08070844
111Buphthalmos (HP:0000557)2.06862640
112Progressive macrocephaly (HP:0004481)2.06575471
113Abnormality of the astrocytes (HP:0100707)2.06380759
114Astrocytoma (HP:0009592)2.06380759
115Heart block (HP:0012722)2.06015734
116Spondylolisthesis (HP:0003302)2.05027156
117Abnormality of the hip-girdle musculature (HP:0001445)2.04684832
118Abnormality of the musculature of the pelvis (HP:0001469)2.04684832
119Slender build (HP:0001533)2.02963199
120Acute encephalopathy (HP:0006846)2.01527609
121Hypoplastic ischia (HP:0003175)1.99160962
122Lower limb amyotrophy (HP:0007210)1.98933962
123Proximal amyotrophy (HP:0007126)1.98691310
124Atrioventricular block (HP:0001678)1.98048789
125Neonatal respiratory distress (HP:0002643)1.95359164
126Ependymoma (HP:0002888)1.90608656
127Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.89944237
128Short 1st metacarpal (HP:0010034)1.89944237
129Hemiparesis (HP:0001269)1.89678071
130Wrist flexion contracture (HP:0001239)1.87860886
131Aortic regurgitation (HP:0001659)1.82538983
132Hypothermia (HP:0002045)1.81009733
133Aplasia/Hypoplasia of the tongue (HP:0010295)1.80828853
134Disproportionate short-trunk short stature (HP:0003521)1.78824211
135Broad metatarsal (HP:0001783)1.78332888
136Neonatal short-limb short stature (HP:0008921)1.77388948
137Hamartoma of the eye (HP:0010568)1.76153167
138Arterial tortuosity (HP:0005116)1.75283233
139Ovoid vertebral bodies (HP:0003300)1.74832387
140Choroideremia (HP:0001139)1.73831993
141Long clavicles (HP:0000890)1.72768660
142Adactyly (HP:0009776)1.72536529
143Nephronophthisis (HP:0000090)1.69259943
144Facial hemangioma (HP:0000329)1.69148859
145Abnormality of the ischium (HP:0003174)1.68498465
146Congenital hepatic fibrosis (HP:0002612)1.66157234
147Corneal dystrophy (HP:0001131)1.65358404
148Intestinal atresia (HP:0011100)1.58574629
149Abnormality of the 1st metacarpal (HP:0010009)1.58473558
150Tarsal synostosis (HP:0008368)1.56242115
151Medial flaring of the eyebrow (HP:0010747)1.52244278

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.76568068
2TTN5.08822314
3PHKG14.15166193
4PHKG24.15166193
5MUSK4.09666333
6FRK4.00064759
7NME12.94869286
8PIK3CG2.78394641
9NUAK12.29159162
10CDK192.18084993
11STK391.99456334
12WEE11.97823635
13NEK91.94855588
14CASK1.86684578
15ZAK1.86613165
16ERBB31.83914600
17PDK31.82743892
18PDK41.82743892
19MAP4K21.80876811
20GRK11.78606429
21TRIM281.71400924
22PINK11.64918072
23PNCK1.63754234
24PLK21.60189417
25PKN11.56354643
26DMPK1.56323111
27PAK31.52353908
28EIF2AK31.52022735
29EPHB11.51927812
30PDK21.50059755
31MOS1.46091929
32WNK31.43697094
33CAMK2D1.38466301
34TNIK1.38398150
35BRSK21.37384706
36PIK3CA1.35497023
37MYLK1.33829999
38OXSR11.27542370
39STK38L1.27495761
40LATS21.27145000
41CCNB11.26900235
42LMTK21.26116405
43WNK41.18897931
44GRK71.18791230
45PLK31.16159674
46ROCK21.14440397
47TGFBR21.12310471
48AKT31.12011330
49STK31.11632105
50CDC71.09240723
51FLT30.97773781
52TRPM70.97237190
53NEK10.96166748
54WNK10.95798049
55CAMK2G0.94434980
56VRK20.91832464
57STK240.91664889
58MAPK120.89432766
59CAMK2A0.86471100
60PRKCE0.82609779
61VRK10.82171441
62IRAK10.80236490
63PIM20.80080493
64CAMK2B0.79603546
65MARK10.78717574
66TLK10.78550440
67IRAK30.78512580
68ROCK10.77695607
69TIE10.77515071
70ILK0.76909508
71PRKD10.73418549
72EPHA20.72436024
73PAK20.72345682
74LIMK10.71160000
75MKNK20.67721986
76NEK60.67674579
77INSRR0.66191702
78MAPKAPK30.65569884
79NTRK10.64952168
80TGFBR10.64766201
81MAP2K10.64609367
82MET0.64566187
83CSNK1G10.61909978
84IRAK20.60328117
85NTRK30.59596187
86ACVR1B0.56177376
87ARAF0.55705006
88KIT0.55484180
89PRKACB0.55372006
90FGFR20.55124845
91BCR0.54888455
92PRKAA10.54503165
93PRKG10.53433298
94PRKACA0.52885630
95BCKDK0.51773709
96DYRK20.51031780
97EIF2AK20.50347650
98CDC42BPA0.50020706
99CDK11A0.48992596
100ADRBK10.48840496
101PRKD30.48280519
102CDK140.47897023
103GSK3A0.47435081
104ABL20.46889388
105EIF2AK10.46872916
106MST40.45786765
107PRKD20.44462761
108MAPK70.44414753
109PLK40.44057965
110BUB10.43966721
111RPS6KA50.43934279
112FER0.42310210
113PRKCG0.41855790
114LATS10.41592644
115CDK150.41357440
116CAMKK20.41225907
117PLK10.41207695
118PRKG20.40987347
119STK160.40534290
120EPHB20.39675098
121PRKAA20.39614713
122ADRBK20.39198900
123MAP2K60.38840754
124CDK180.38542576
125AKT20.38449827
126MAPK130.37660497
127PDPK10.37376931
128FGFR30.36731956
129MAP3K70.34965866
130PAK60.34011713
131PRKCI0.33786189
132GRK50.33669189
133NLK0.33529561
134CSNK1G30.32764859
135CSNK1G20.32458212
136CDK30.30362888
137CSNK1A1L0.30211023
138ERBB40.29735961
139UHMK10.29636974
140CSNK1E0.28947890
141FGR0.28543468
142ABL10.28425449
143SGK2230.26201895
144SGK4940.26201895
145MARK20.25742749
146BMPR1B0.25612896
147DDR20.24177499
148DAPK30.24058301
149PTK2B0.23768180
150SGK10.22673288

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.82398416
2Cardiac muscle contraction_Homo sapiens_hsa042604.38915024
3Parkinsons disease_Homo sapiens_hsa050124.06013158
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.93038655
5Dilated cardiomyopathy_Homo sapiens_hsa054143.73189844
6Alzheimers disease_Homo sapiens_hsa050103.28760675
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.13912300
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.78007344
9Huntingtons disease_Homo sapiens_hsa050162.76877386
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.70395580
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.24216099
12Fatty acid elongation_Homo sapiens_hsa000621.99849503
13Homologous recombination_Homo sapiens_hsa034401.76798636
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68112250
15Basal transcription factors_Homo sapiens_hsa030221.65960032
16Nitrogen metabolism_Homo sapiens_hsa009101.65403198
17Proteasome_Homo sapiens_hsa030501.59363562
18Vitamin B6 metabolism_Homo sapiens_hsa007501.57500170
19Fatty acid degradation_Homo sapiens_hsa000711.51775223
20Phototransduction_Homo sapiens_hsa047441.51613617
21Fanconi anemia pathway_Homo sapiens_hsa034601.51089026
22Protein export_Homo sapiens_hsa030601.50698088
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49974499
24Regulation of autophagy_Homo sapiens_hsa041401.36905882
25RNA polymerase_Homo sapiens_hsa030201.29781807
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.26507235
27Tight junction_Homo sapiens_hsa045301.25937717
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20893274
29Tryptophan metabolism_Homo sapiens_hsa003801.20440015
30Arginine and proline metabolism_Homo sapiens_hsa003301.18937274
31Viral myocarditis_Homo sapiens_hsa054161.18555406
32Selenocompound metabolism_Homo sapiens_hsa004501.16539499
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.15798495
34TGF-beta signaling pathway_Homo sapiens_hsa043501.11650365
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07387870
36Collecting duct acid secretion_Homo sapiens_hsa049661.05578439
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05491652
38Basal cell carcinoma_Homo sapiens_hsa052171.01938652
39ECM-receptor interaction_Homo sapiens_hsa045121.01395137
40Oxytocin signaling pathway_Homo sapiens_hsa049211.01299064
41Calcium signaling pathway_Homo sapiens_hsa040200.96205871
42Ether lipid metabolism_Homo sapiens_hsa005650.95464325
43Linoleic acid metabolism_Homo sapiens_hsa005910.94656531
44RNA degradation_Homo sapiens_hsa030180.92017399
45Sphingolipid metabolism_Homo sapiens_hsa006000.91097812
46Vibrio cholerae infection_Homo sapiens_hsa051100.89276577
47Salivary secretion_Homo sapiens_hsa049700.88873362
48Protein digestion and absorption_Homo sapiens_hsa049740.88812558
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88615365
50beta-Alanine metabolism_Homo sapiens_hsa004100.84287349
51Sulfur metabolism_Homo sapiens_hsa009200.84024300
52Circadian rhythm_Homo sapiens_hsa047100.83499005
53Steroid biosynthesis_Homo sapiens_hsa001000.80645748
54Serotonergic synapse_Homo sapiens_hsa047260.79036741
55Focal adhesion_Homo sapiens_hsa045100.78852825
56Hippo signaling pathway_Homo sapiens_hsa043900.78794717
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.78756523
58Taste transduction_Homo sapiens_hsa047420.77477572
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76651173
60Peroxisome_Homo sapiens_hsa041460.74586994
61Propanoate metabolism_Homo sapiens_hsa006400.74561409
62Insulin secretion_Homo sapiens_hsa049110.74335807
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73598480
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70736084
65Arachidonic acid metabolism_Homo sapiens_hsa005900.68461840
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68299367
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67244642
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66930571
69Axon guidance_Homo sapiens_hsa043600.66921290
70Olfactory transduction_Homo sapiens_hsa047400.66299426
71Renal cell carcinoma_Homo sapiens_hsa052110.65846056
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65739294
73Carbon metabolism_Homo sapiens_hsa012000.64947566
74Ovarian steroidogenesis_Homo sapiens_hsa049130.64867261
75p53 signaling pathway_Homo sapiens_hsa041150.63630503
76One carbon pool by folate_Homo sapiens_hsa006700.63372742
77Insulin signaling pathway_Homo sapiens_hsa049100.63162619
78Nucleotide excision repair_Homo sapiens_hsa034200.59803757
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59315220
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59089953
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58254653
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56902819
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.55787137
84Fatty acid metabolism_Homo sapiens_hsa012120.55155325
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53553784
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53265458
87Non-homologous end-joining_Homo sapiens_hsa034500.52225007
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51546112
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51526031
90GnRH signaling pathway_Homo sapiens_hsa049120.51411171
91Amphetamine addiction_Homo sapiens_hsa050310.50936614
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49241253
93Purine metabolism_Homo sapiens_hsa002300.49146815
94Phagosome_Homo sapiens_hsa041450.48639488
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48570315
96Retinol metabolism_Homo sapiens_hsa008300.48333482
97Dorso-ventral axis formation_Homo sapiens_hsa043200.48048680
98Oocyte meiosis_Homo sapiens_hsa041140.47317687
99Metabolic pathways_Homo sapiens_hsa011000.46810988
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46252066
101Glucagon signaling pathway_Homo sapiens_hsa049220.45968637
102Caffeine metabolism_Homo sapiens_hsa002320.45963785
103Cholinergic synapse_Homo sapiens_hsa047250.45751126
104Long-term depression_Homo sapiens_hsa047300.44343542
105Renin secretion_Homo sapiens_hsa049240.42426788
106Rheumatoid arthritis_Homo sapiens_hsa053230.42317634
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42271127
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42139976
109Circadian entrainment_Homo sapiens_hsa047130.41652828
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40469173
111Cocaine addiction_Homo sapiens_hsa050300.40100868
112Lysine degradation_Homo sapiens_hsa003100.39894287
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39826209
114Morphine addiction_Homo sapiens_hsa050320.39694580
115MAPK signaling pathway_Homo sapiens_hsa040100.39322377
116Amoebiasis_Homo sapiens_hsa051460.39099334
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38638574
118Starch and sucrose metabolism_Homo sapiens_hsa005000.38122340
119GABAergic synapse_Homo sapiens_hsa047270.36364040
120Gastric acid secretion_Homo sapiens_hsa049710.34329631
121Melanoma_Homo sapiens_hsa052180.34210228
122Butanoate metabolism_Homo sapiens_hsa006500.33572130
123Gap junction_Homo sapiens_hsa045400.33415640
124Adherens junction_Homo sapiens_hsa045200.32933032
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32562489
126Renin-angiotensin system_Homo sapiens_hsa046140.31354530
127AMPK signaling pathway_Homo sapiens_hsa041520.30478100
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30310900
129Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30209580
130Hedgehog signaling pathway_Homo sapiens_hsa043400.29941376
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28876636
132FoxO signaling pathway_Homo sapiens_hsa040680.28742847
133Synaptic vesicle cycle_Homo sapiens_hsa047210.28718271
134Melanogenesis_Homo sapiens_hsa049160.28678668
135Pyruvate metabolism_Homo sapiens_hsa006200.28150261
136Wnt signaling pathway_Homo sapiens_hsa043100.27910028
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27048007
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26861161
139Glutamatergic synapse_Homo sapiens_hsa047240.26323848
140cAMP signaling pathway_Homo sapiens_hsa040240.24400911
141Ras signaling pathway_Homo sapiens_hsa040140.22500938
142Ribosome_Homo sapiens_hsa030100.22095260
143Pancreatic secretion_Homo sapiens_hsa049720.21619098
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21049584
145Dopaminergic synapse_Homo sapiens_hsa047280.20130068

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