SYMPK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mannose metabolic process (GO:0006013)4.74341689
2negative regulation of erythrocyte differentiation (GO:0045647)4.64875787
3pre-miRNA processing (GO:0031054)4.39137942
4histone H3-K36 demethylation (GO:0070544)3.86723019
5activation of Rac GTPase activity (GO:0032863)3.84137648
6cytoskeletal anchoring at plasma membrane (GO:0007016)3.77655751
7regulation of histone H3-K27 methylation (GO:0061085)3.69517701
8positive regulation of histone deacetylation (GO:0031065)3.53362979
9heterochromatin organization (GO:0070828)3.53052620
10positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.42812325
11nuclear pore complex assembly (GO:0051292)3.39264468
12regulation of glucose import in response to insulin stimulus (GO:2001273)3.30027787
13peptidyl-lysine dimethylation (GO:0018027)3.28832435
14thymic T cell selection (GO:0045061)3.27263890
15cytoplasmic mRNA processing body assembly (GO:0033962)3.20984916
16activation of MAPKKK activity (GO:0000185)3.16551809
17positive regulation of RNA splicing (GO:0033120)3.14795984
183-UTR-mediated mRNA stabilization (GO:0070935)3.12945793
19regulation of mammary gland epithelial cell proliferation (GO:0033599)3.12055122
20regulation of hippo signaling (GO:0035330)3.10694034
21regulation of early endosome to late endosome transport (GO:2000641)3.07160001
22regulation of translational fidelity (GO:0006450)3.05696052
23stress granule assembly (GO:0034063)3.05448280
24modulation by virus of host process (GO:0019054)3.03349402
25modulation by symbiont of host cellular process (GO:0044068)3.02680151
26intracellular estrogen receptor signaling pathway (GO:0030520)3.00664322
27nuclear pore organization (GO:0006999)3.00252377
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.00220118
29negative regulation of translation, ncRNA-mediated (GO:0040033)3.00220118
30regulation of translation, ncRNA-mediated (GO:0045974)3.00220118
31paraxial mesoderm development (GO:0048339)2.99846075
32regulation of nucleobase-containing compound transport (GO:0032239)2.99065882
33negative regulation of viral release from host cell (GO:1902187)2.98158907
34glucocorticoid receptor signaling pathway (GO:0042921)2.98111458
35positive regulation of gene expression, epigenetic (GO:0045815)2.96252353
36COPI coating of Golgi vesicle (GO:0048205)2.95413924
37Golgi transport vesicle coating (GO:0048200)2.95413924
38regulation of RNA export from nucleus (GO:0046831)2.95323586
39NLS-bearing protein import into nucleus (GO:0006607)2.95266814
40embryonic process involved in female pregnancy (GO:0060136)2.91070411
41histone lysine demethylation (GO:0070076)2.89230034
42regulation of NFAT protein import into nucleus (GO:0051532)2.88798173
43plasma membrane repair (GO:0001778)2.88690520
44histone H3-K4 trimethylation (GO:0080182)2.88650615
45positive regulation of Cdc42 GTPase activity (GO:0043089)2.88476883
46adherens junction assembly (GO:0034333)2.85560755
47negative regulation of cell size (GO:0045792)2.84159968
48RNA stabilization (GO:0043489)2.83385300
49mRNA stabilization (GO:0048255)2.83385300
50negative regulation of fatty acid transport (GO:2000192)2.81797301
51positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.80178188
52cellular response to epidermal growth factor stimulus (GO:0071364)2.79739899
53activation of JUN kinase activity (GO:0007257)2.78578791
54negative regulation of histone methylation (GO:0031061)2.77862692
55focal adhesion assembly (GO:0048041)2.77535262
56cell-substrate adherens junction assembly (GO:0007045)2.77535262
57histone H3-K4 methylation (GO:0051568)2.77265835
58planar cell polarity pathway involved in neural tube closure (GO:0090179)2.77101534
59negative regulation of myotube differentiation (GO:0010832)2.76964127
60positive regulation of protein deacetylation (GO:0090312)2.76226591
61snRNA metabolic process (GO:0016073)2.75954914
62chromatin assembly (GO:0031497)2.75216669
63proline biosynthetic process (GO:0006561)2.74635043
64insulin-like growth factor receptor signaling pathway (GO:0048009)2.73880664
65regulation of type I interferon-mediated signaling pathway (GO:0060338)2.73657014
66protein localization to endosome (GO:0036010)2.73218584
67histone H4-K12 acetylation (GO:0043983)2.72947560
68head development (GO:0060322)2.72544390
69histone demethylation (GO:0016577)2.72088385
70histone H4 deacetylation (GO:0070933)2.71681163
71response to muramyl dipeptide (GO:0032495)2.71335093
72regulation of gene silencing by RNA (GO:0060966)2.70889961
73regulation of posttranscriptional gene silencing (GO:0060147)2.70889961
74regulation of gene silencing by miRNA (GO:0060964)2.70889961
75regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.70725070
76polarized epithelial cell differentiation (GO:0030859)2.67669438
77regulation of cholesterol homeostasis (GO:2000188)2.65210522
78regulation of histone H3-K9 methylation (GO:0051570)2.65183049
79antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.64180099
80histone H3-K9 methylation (GO:0051567)2.64057121
81chromatin silencing (GO:0006342)2.63862048
82spliceosomal tri-snRNP complex assembly (GO:0000244)2.62489404
83basement membrane organization (GO:0071711)2.62406524
84cellular response to virus (GO:0098586)2.62205006
85NIK/NF-kappaB signaling (GO:0038061)2.62109790
86retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.61236373
87positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.60997110
88establishment of apical/basal cell polarity (GO:0035089)2.60993108
89cell-cell junction maintenance (GO:0045217)2.59768675
90antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.59731470
91germinal center formation (GO:0002467)2.59607085
92apoptotic process involved in morphogenesis (GO:0060561)2.57702794
93response to laminar fluid shear stress (GO:0034616)2.57139121
94histone lysine methylation (GO:0034968)2.57120684
95maternal placenta development (GO:0001893)2.54197721
96regulation of DNA damage checkpoint (GO:2000001)2.52991788
97mRNA splice site selection (GO:0006376)2.52936623
98histone H3-K9 demethylation (GO:0033169)2.52629194
99DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.52027851
100regulation of ARF protein signal transduction (GO:0032012)2.51042598
101positive regulation of blood vessel endothelial cell migration (GO:0043536)2.50525416
102signal complex assembly (GO:0007172)2.49481793
103histone H3-K9 modification (GO:0061647)2.49325209
104cell-substrate junction assembly (GO:0007044)2.47659494
105endothelial cell chemotaxis (GO:0035767)2.47321045
106positive regulation of gamma-delta T cell activation (GO:0046645)2.46803617
107regulation of extracellular matrix disassembly (GO:0010715)2.46766554
108pentose-phosphate shunt (GO:0006098)2.46725394
109layer formation in cerebral cortex (GO:0021819)2.46502413
110corticosteroid receptor signaling pathway (GO:0031958)2.45925292
111stress fiber assembly (GO:0043149)2.44615648
112DNA unwinding involved in DNA replication (GO:0006268)2.43953520
113CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.43454576
114gene silencing (GO:0016458)2.42604505
115T cell selection (GO:0045058)2.42537246
116histone H4-K16 acetylation (GO:0043984)2.42299528
117response to epidermal growth factor (GO:0070849)2.42145454
118response to UV-C (GO:0010225)2.40869410
119mitotic sister chromatid cohesion (GO:0007064)2.40498036
120peptidyl-threonine phosphorylation (GO:0018107)2.40351318
121regulation of integrin activation (GO:0033623)2.39647663
122apoptotic process involved in development (GO:1902742)2.39486108
123epithelial cell differentiation involved in prostate gland development (GO:0060742)2.39322877
124atrioventricular valve morphogenesis (GO:0003181)2.38776187
125positive regulation of CREB transcription factor activity (GO:0032793)2.38536250
126dendritic spine morphogenesis (GO:0060997)2.38424779
127embryonic retina morphogenesis in camera-type eye (GO:0060059)2.37825748
128positive regulation of fibroblast migration (GO:0010763)2.37653655
129antigen processing and presentation of endogenous antigen (GO:0019883)2.36625072
130intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.35554026
131negative regulation of organelle assembly (GO:1902116)2.35298984
132peptidyl-threonine modification (GO:0018210)2.35111425
133regulation of fatty acid beta-oxidation (GO:0031998)2.35048611
134modulation by virus of host morphology or physiology (GO:0019048)2.34394121
135protein dealkylation (GO:0008214)2.33957956
136protein demethylation (GO:0006482)2.33957956
137snRNA processing (GO:0016180)2.33772321
138activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.32623123
139regulation of chromatin binding (GO:0035561)2.32445968
140histone H3 deacetylation (GO:0070932)2.31611521
141negative regulation of mRNA metabolic process (GO:1903312)2.30548077
142histone methylation (GO:0016571)2.30109059
143glucose 6-phosphate metabolic process (GO:0051156)2.29028889
144negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.28663901
145negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.27626704
146histone H4-K5 acetylation (GO:0043981)2.26839764
147histone H4-K8 acetylation (GO:0043982)2.26839764
148establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.26634997
149regulation of ARF GTPase activity (GO:0032312)2.26486182
150pore complex assembly (GO:0046931)2.25178128
151mitotic chromosome condensation (GO:0007076)2.25000494
152vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.24505375
153nucleosome disassembly (GO:0006337)2.24383678
154protein-DNA complex disassembly (GO:0032986)2.24383678
155neural tube development (GO:0021915)2.22951906
156negative regulation of granulocyte differentiation (GO:0030853)2.22747881
157heart morphogenesis (GO:0003007)2.21611825
158peptidyl-lysine trimethylation (GO:0018023)2.21234062
159negative regulation of mRNA processing (GO:0050686)2.20454812
160gastrulation with mouth forming second (GO:0001702)2.19306571
161cell migration in hindbrain (GO:0021535)2.18442381
162establishment of nucleus localization (GO:0040023)2.18198598
163cerebellar Purkinje cell differentiation (GO:0021702)2.16763195
164positive thymic T cell selection (GO:0045059)2.16726127
165negative regulation of gene expression, epigenetic (GO:0045814)2.15778420
166regulation of mRNA stability (GO:0043488)2.15385222
167determination of adult lifespan (GO:0008340)2.14844356
168protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.14679721
169myoblast fusion (GO:0007520)2.14270371
170peptidyl-lysine methylation (GO:0018022)2.13494650
171neural tube closure (GO:0001843)2.12334983
172negative regulation of nucleotide catabolic process (GO:0030812)2.11887337
173spindle assembly involved in mitosis (GO:0090307)2.11824014
174semaphorin-plexin signaling pathway (GO:0071526)2.11613213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human3.97990483
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.69718346
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.54302111
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.36913385
5E2F7_22180533_ChIP-Seq_HELA_Human3.05523050
6EZH2_22144423_ChIP-Seq_EOC_Human2.95302066
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.72205507
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.60231099
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.32665144
10KDM2B_26808549_Chip-Seq_DND41_Human2.32299734
11DROSHA_22980978_ChIP-Seq_HELA_Human2.32094844
12ZFP281_27345836_Chip-Seq_ESCs_Mouse2.31089966
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28858997
14MYC_22102868_ChIP-Seq_BL_Human2.25641690
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.16389611
16KDM2B_26808549_Chip-Seq_K562_Human2.10546497
17TCF7_22412390_ChIP-Seq_EML_Mouse2.03490774
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.00093452
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.99748536
20ZFP281_18757296_ChIP-ChIP_E14_Mouse1.98651202
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.91087564
22KDM2B_26808549_Chip-Seq_JURKAT_Human1.80425142
23VDR_24763502_ChIP-Seq_THP-1_Human1.75759764
24DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.74859763
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.72052218
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.70044314
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.70022715
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.67420772
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64859027
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62534065
31LXR_22292898_ChIP-Seq_THP-1_Human1.60510417
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58083055
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55510363
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.53539402
35SA1_27219007_Chip-Seq_ERYTHROID_Human1.53461456
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50582019
37* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48932939
38MAF_26560356_Chip-Seq_TH2_Human1.48314063
39TET1_21451524_ChIP-Seq_MESCs_Mouse1.48263342
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.46886730
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.43515291
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43213101
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43016369
44VDR_21846776_ChIP-Seq_THP-1_Human1.42711783
45P300_27058665_Chip-Seq_ZR-75-30cells_Human1.41665146
46ZNF263_19887448_ChIP-Seq_K562_Human1.40939426
47ISL1_27105846_Chip-Seq_CPCs_Mouse1.39514169
48FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.38187401
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.35444919
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.33779360
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32086963
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28542869
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.26181016
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25425247
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25345488
56CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25058367
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24566881
58TP53_22127205_ChIP-Seq_IMR90_Human1.23191335
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23032007
60CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22781603
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22319359
62BCOR_27268052_Chip-Seq_Bcells_Human1.22015413
63CREB1_26743006_Chip-Seq_LNCaP_Human1.21895045
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21279382
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21219749
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20971513
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20915364
68RACK7_27058665_Chip-Seq_MCF-7_Human1.20905886
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20417206
70CTCF_27219007_Chip-Seq_Bcells_Human1.18642249
71* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18162277
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.17561451
73SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16730643
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16369727
75NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14926183
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14365323
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14013720
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13563432
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13128206
80P68_20966046_ChIP-Seq_HELA_Human1.12325782
81ATF3_27146783_Chip-Seq_COLON_Human1.12278679
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11983896
83TP63_17297297_ChIP-ChIP_HaCaT_Human1.10510220
84GATA1_26923725_Chip-Seq_HPCs_Mouse1.10422149
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09799848
86* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.09459447
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09381910
88* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09283514
89MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08441122
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08109012
91RUNX1_27514584_Chip-Seq_MCF-7_Human1.07366676
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06686268
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06480975
94TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06423945
95BCL6_27268052_Chip-Seq_Bcells_Human1.05533865
96RING1B_27294783_Chip-Seq_NPCs_Mouse1.05498375
97RNF2_27304074_Chip-Seq_ESCs_Mouse1.05454170
98CLOCK_20551151_ChIP-Seq_293T_Human1.05116245
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04895521
100ELK4_26923725_Chip-Seq_MESODERM_Mouse1.04801993
101* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04129775
102MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04125560
103CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04061528
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03081065
105ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02490812
106AR_19668381_ChIP-Seq_PC3_Human1.02407445
107SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02258395
108UTX_26944678_Chip-Seq_JUKART_Human1.02008718
109AHR_22903824_ChIP-Seq_MCF-7_Human0.99708719
110SCL_19346495_ChIP-Seq_HPC-7_Human0.99154745
111* TP63_22573176_ChIP-Seq_HFKS_Human0.98918993
112POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98327743
113CIITA_25753668_ChIP-Seq_RAJI_Human0.98070786
114ERG_21242973_ChIP-ChIP_JURKAT_Human0.97898613
115PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97766486
116RARA_24833708_ChIP-Seq_LIVER_Mouse0.97460352
117DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97371985
118SPI1_23127762_ChIP-Seq_K562_Human0.97282015
119OCT4_19829295_ChIP-Seq_ESCs_Human0.97099871
120RARB_24833708_ChIP-Seq_LIVER_Mouse0.96607198
121EZH2_27294783_Chip-Seq_ESCs_Mouse0.96508046
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95834966
123PHF8_20622854_ChIP-Seq_HELA_Human0.95790166
124RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95664486
125PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95557543
126TP53_16413492_ChIP-PET_HCT116_Human0.95460495
127EZH2_18974828_ChIP-Seq_MESCs_Mouse0.94922894
128RNF2_18974828_ChIP-Seq_MESCs_Mouse0.94922894
129FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94483809
130TBX20_22080862_ChIP-Seq_HEART_Mouse0.94081221
131TBX20_22328084_ChIP-Seq_HEART_Mouse0.94081221
132YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93766055
133RING1B_27294783_Chip-Seq_ESCs_Mouse0.93124886
134CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.92545485
135NCOR1_26117541_ChIP-Seq_K562_Human0.92509667
136UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90957287
137ESR2_21235772_ChIP-Seq_MCF-7_Human0.90628221
138TP53_23651856_ChIP-Seq_MEFs_Mouse0.90118079
139NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.89701527
140TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89653923
141SALL1_21062744_ChIP-ChIP_HESCs_Human0.88807814
142RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88664444
143MAF_26560356_Chip-Seq_TH1_Human0.88293742
144OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87922604
145STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.87787597
146SUZ12_27294783_Chip-Seq_ESCs_Mouse0.87220313
147CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87111951
148* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.84724211
149JARID2_20064375_ChIP-Seq_MESCs_Mouse0.84314693
150SMC4_20622854_ChIP-Seq_HELA_Human0.84154738
151NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.83867557

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.54841328
2MP0003283_abnormal_digestive_organ3.11586028
3MP0003705_abnormal_hypodermis_morpholog3.10479378
4MP0005451_abnormal_body_composition3.06665290
5MP0005076_abnormal_cell_differentiation2.97433969
6MP0005623_abnormal_meninges_morphology2.84128222
7MP0008961_abnormal_basal_metabolism2.72463613
8MP0005058_abnormal_lysosome_morphology2.52218099
9MP0001348_abnormal_lacrimal_gland2.33072238
10MP0005409_darkened_coat_color2.21836308
11MP0004859_abnormal_synaptic_plasticity2.07763404
12MP0003436_decreased_susceptibility_to2.06725198
13MP0003111_abnormal_nucleus_morphology2.03286904
14MP0004185_abnormal_adipocyte_glucose1.98882092
15MP0003045_fibrosis1.96674437
16MP0008260_abnormal_autophagy1.88179451
17MP0010307_abnormal_tumor_latency1.85852254
18MP0000733_abnormal_muscle_development1.85478324
19MP0003453_abnormal_keratinocyte_physiol1.84082725
20MP0002877_abnormal_melanocyte_morpholog1.83143064
21MP0003763_abnormal_thymus_physiology1.82726615
22MP0003787_abnormal_imprinting1.80820481
23MP0004197_abnormal_fetal_growth/weight/1.79307565
24MP0001849_ear_inflammation1.78926662
25MP0004947_skin_inflammation1.74638690
26MP0009278_abnormal_bone_marrow1.73020691
27MP0000678_abnormal_parathyroid_gland1.70624849
28MP0009840_abnormal_foam_cell1.66398419
29MP0003566_abnormal_cell_adhesion1.66012107
30MP0000685_abnormal_immune_system1.65550459
31MP0005670_abnormal_white_adipose1.64641404
32MP0001873_stomach_inflammation1.61174760
33MP0000751_myopathy1.59060121
34MP0000383_abnormal_hair_follicle1.58281006
35MP0004233_abnormal_muscle_weight1.57923438
36MP0003300_gastrointestinal_ulcer1.51713697
37MP0002249_abnormal_larynx_morphology1.50745710
38MP0003121_genomic_imprinting1.49508286
39MP0005666_abnormal_adipose_tissue1.48430298
40MP0009672_abnormal_birth_weight1.44327695
41MP0009703_decreased_birth_body1.42458689
42MP0002234_abnormal_pharynx_morphology1.41561641
43MP0008438_abnormal_cutaneous_collagen1.40427445
44MP0010352_gastrointestinal_tract_polyps1.40262745
45MP0000537_abnormal_urethra_morphology1.40250967
46MP0004381_abnormal_hair_follicle1.39331295
47MP0005375_adipose_tissue_phenotype1.38731269
48MP0009333_abnormal_splenocyte_physiolog1.38488717
49MP0002697_abnormal_eye_size1.38080078
50MP0000858_altered_metastatic_potential1.37807947
51MP0010678_abnormal_skin_adnexa1.36883640
52MP0002084_abnormal_developmental_patter1.36701799
53MP0005257_abnormal_intraocular_pressure1.33848722
54MP0003115_abnormal_respiratory_system1.33261632
55MP0000462_abnormal_digestive_system1.32909768
56MP0003119_abnormal_digestive_system1.29124816
57MP0003890_abnormal_embryonic-extraembry1.28269941
58MP0008770_decreased_survivor_rate1.25560187
59MP0003091_abnormal_cell_migration1.24061682
60MP0002085_abnormal_embryonic_tissue1.22972278
61MP0003385_abnormal_body_wall1.22012843
62MP0003861_abnormal_nervous_system1.21783482
63MP0000003_abnormal_adipose_tissue1.21742050
64MP0002796_impaired_skin_barrier1.21432994
65MP0005380_embryogenesis_phenotype1.20786031
66MP0001672_abnormal_embryogenesis/_devel1.20786031
67MP0003279_aneurysm1.19158953
68MP0008057_abnormal_DNA_replication1.18891027
69MP0000428_abnormal_craniofacial_morphol1.17735470
70MP0004510_myositis1.15866128
71MP0004087_abnormal_muscle_fiber1.14209303
72MP0003935_abnormal_craniofacial_develop1.13648386
73MP0005621_abnormal_cell_physiology1.13159219
74MP0010030_abnormal_orbit_morphology1.11977680
75MP0003122_maternal_imprinting1.11685339
76MP0000703_abnormal_thymus_morphology1.10817268
77MP0010630_abnormal_cardiac_muscle1.10519866
78MP0005410_abnormal_fertilization1.09703815
79MP0002925_abnormal_cardiovascular_devel1.07120548
80MP0004264_abnormal_extraembryonic_tissu1.07109936
81MP0002653_abnormal_ependyma_morphology1.07081264
82MP0002398_abnormal_bone_marrow1.06663565
83MP0004145_abnormal_muscle_electrophysio1.06548125
84MP0001790_abnormal_immune_system1.06376477
85MP0005387_immune_system_phenotype1.06376477
86MP0005023_abnormal_wound_healing1.05750444
87MP0000759_abnormal_skeletal_muscle1.05533655
88MP0003984_embryonic_growth_retardation1.04933750
89MP0002086_abnormal_extraembryonic_tissu1.04898548
90MP0002088_abnormal_embryonic_growth/wei1.04778504
91MP0001835_abnormal_antigen_presentation1.04681995
92MP0009780_abnormal_chondrocyte_physiolo1.02956403
93MP0004808_abnormal_hematopoietic_stem1.02293225
94MP0002254_reproductive_system_inflammat1.02282477
95MP0002998_abnormal_bone_remodeling1.01685637
96MP0003172_abnormal_lysosome_physiology1.01556663
97MP0000432_abnormal_head_morphology1.01282102
98MP0001800_abnormal_humoral_immune1.00850286
99MP0004858_abnormal_nervous_system0.99479082
100MP0003329_amyloid_beta_deposits0.99144882
101MP0005501_abnormal_skin_physiology0.99027901
102MP0002060_abnormal_skin_morphology0.98783264
103MP0005025_abnormal_response_to0.98714832
104MP0003191_abnormal_cellular_cholesterol0.98328915
105MP0008877_abnormal_DNA_methylation0.98254166
106MP0000266_abnormal_heart_morphology0.96960078
107MP0002933_joint_inflammation0.96815610
108MP0005000_abnormal_immune_tolerance0.96474116
109MP0002092_abnormal_eye_morphology0.96250820
110MP0000767_abnormal_smooth_muscle0.96244418
111MP0009931_abnormal_skin_appearance0.95892563
112MP0001299_abnormal_eye_distance/0.95215066
113MP0000566_synostosis0.93722395
114MP0001730_embryonic_growth_arrest0.92114894
115MP0010155_abnormal_intestine_physiology0.91612581
116MP0003941_abnormal_skin_development0.89977023
117MP0003123_paternal_imprinting0.88794742
118MP0002116_abnormal_craniofacial_bone0.88563629
119MP0002166_altered_tumor_susceptibility0.88537139
120MP0001486_abnormal_startle_reflex0.88467937
121MP0002396_abnormal_hematopoietic_system0.88332311
122MP0008995_early_reproductive_senescence0.87099139
123MP0002419_abnormal_innate_immunity0.87023392
124MP0001958_emphysema0.86403475
125MP0000490_abnormal_crypts_of0.86204824
126MP0002111_abnormal_tail_morphology0.86125452
127MP0002269_muscular_atrophy0.86109406
128MP0002429_abnormal_blood_cell0.85126019
129MP0002970_abnormal_white_adipose0.84941863
130MP0010094_abnormal_chromosome_stability0.84831775
131MP0005083_abnormal_biliary_tract0.84802021
132MP0001545_abnormal_hematopoietic_system0.84508491
133MP0005397_hematopoietic_system_phenotyp0.84508491
134MP0000716_abnormal_immune_system0.84370768
135MP0002420_abnormal_adaptive_immunity0.84358416
136MP0010234_abnormal_vibrissa_follicle0.84176076
137MP0001819_abnormal_immune_cell0.83897634
138MP0002452_abnormal_antigen_presenting0.83656770
139MP0000579_abnormal_nail_morphology0.83255239
140MP0000534_abnormal_ureter_morphology0.83027694
141MP0002089_abnormal_postnatal_growth/wei0.82955097
142MP0002723_abnormal_immune_serum0.82550228
143MP0000778_abnormal_nervous_system0.82003898
144MP0002152_abnormal_brain_morphology0.81649631
145MP0004885_abnormal_endolymph0.81560435
146MP0002722_abnormal_immune_system0.81162734
147MP0000955_abnormal_spinal_cord0.80079936
148MP0003635_abnormal_synaptic_transmissio0.78549663
149MP0002009_preneoplasia0.77775994
150MP0003303_peritoneal_inflammation0.77173982
151MP0002106_abnormal_muscle_physiology0.77071039
152MP0001784_abnormal_fluid_regulation0.76974256
153MP0003698_abnormal_male_reproductive0.76714909
154MP0000747_muscle_weakness0.76706623
155MP0002932_abnormal_joint_morphology0.76662230
156MP0002081_perinatal_lethality0.76312910
157MP0002080_prenatal_lethality0.75661070
158MP0002114_abnormal_axial_skeleton0.74977223
159MP0000350_abnormal_cell_proliferation0.74897223
160MP0000477_abnormal_intestine_morphology0.73395450

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.82811127
2Broad face (HP:0000283)3.52169060
3Obstructive sleep apnea (HP:0002870)3.40644261
4Distal lower limb amyotrophy (HP:0008944)3.35789338
5Elfin facies (HP:0004428)3.21098702
6Renovascular hypertension (HP:0100817)3.07306640
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.01078359
8Lower limb amyotrophy (HP:0007210)2.99217462
9Renal duplication (HP:0000075)2.89843090
10Insomnia (HP:0100785)2.87817149
11Heterotopia (HP:0002282)2.77996518
12Cerebral aneurysm (HP:0004944)2.76472274
13Overriding aorta (HP:0002623)2.65161230
14Shallow orbits (HP:0000586)2.60304100
15Protrusio acetabuli (HP:0003179)2.58606871
16Ependymoma (HP:0002888)2.56348063
17Short 4th metacarpal (HP:0010044)2.52316172
18Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.52316172
19Chromsome breakage (HP:0040012)2.49854548
20Pseudobulbar signs (HP:0002200)2.49352619
21Thin bony cortex (HP:0002753)2.48618849
22Abnormality of the fingertips (HP:0001211)2.44137300
23Abnormality of the astrocytes (HP:0100707)2.42418925
24Astrocytoma (HP:0009592)2.42418925
25Flat cornea (HP:0007720)2.40428882
26Long palpebral fissure (HP:0000637)2.38195862
27Pointed chin (HP:0000307)2.33572920
28Upper limb muscle weakness (HP:0003484)2.33443683
29Achilles tendon contracture (HP:0001771)2.33173614
30Hemorrhage of the eye (HP:0011885)2.33038419
31Colitis (HP:0002583)2.31270588
32Macroorchidism (HP:0000053)2.27937583
33Flat acetabular roof (HP:0003180)2.26752747
34Neoplasm of the heart (HP:0100544)2.26582086
35Stridor (HP:0010307)2.26165898
36Upper limb amyotrophy (HP:0009129)2.21339409
37Distal upper limb amyotrophy (HP:0007149)2.21339409
38Abnormality of the lower motor neuron (HP:0002366)2.20389923
39Bronchomalacia (HP:0002780)2.19616859
40Centrally nucleated skeletal muscle fibers (HP:0003687)2.15522040
41Increased nuchal translucency (HP:0010880)2.14410521
42Emphysema (HP:0002097)2.13022607
43Cellulitis (HP:0100658)2.12934468
44Metaphyseal cupping (HP:0003021)2.12540071
45Hypoplastic ischia (HP:0003175)2.12370054
46Cervical subluxation (HP:0003308)2.12093737
47Abnormality of the Achilles tendon (HP:0005109)2.09269810
48Supernumerary ribs (HP:0005815)2.08881197
49Abnormality of the thoracic spine (HP:0100711)2.08770272
50Bowel diverticulosis (HP:0005222)2.08598111
51Long eyelashes (HP:0000527)2.08594018
52Abnormality of the 4th metacarpal (HP:0010012)2.06668279
53Ulnar bowing (HP:0003031)2.05869089
54Difficulty running (HP:0009046)2.05571372
55J-shaped sella turcica (HP:0002680)2.04839378
56Hyporeflexia of lower limbs (HP:0002600)2.02765367
57Abnormality of the diencephalon (HP:0010662)2.02760533
58Trigonocephaly (HP:0000243)2.02123113
59Urethral obstruction (HP:0000796)2.01653878
60Dysmetric saccades (HP:0000641)2.00820327
61Premature rupture of membranes (HP:0001788)2.00007122
62Segmental peripheral demyelination/remyelination (HP:0003481)1.99813057
63Bladder diverticulum (HP:0000015)1.98856863
64Dislocated radial head (HP:0003083)1.98702225
65Obsessive-compulsive behavior (HP:0000722)1.98698388
66Turricephaly (HP:0000262)1.97311102
67Skull defect (HP:0001362)1.96912454
68Fragile skin (HP:0001030)1.96161858
69Increased IgE level (HP:0003212)1.94530566
70Mitral regurgitation (HP:0001653)1.94065595
71Persistence of primary teeth (HP:0006335)1.93661015
72Gastrointestinal stroma tumor (HP:0100723)1.92421370
73Duplicated collecting system (HP:0000081)1.91089667
74Broad distal phalanx of finger (HP:0009836)1.89124310
75Abnormality of the radial head (HP:0003995)1.88817194
76Biconcave vertebral bodies (HP:0004586)1.88153908
77Increased connective tissue (HP:0009025)1.87125740
78Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86969339
79Anal stenosis (HP:0002025)1.86694239
80Gastrointestinal inflammation (HP:0004386)1.86633544
81Hand muscle atrophy (HP:0009130)1.86350545
82Abnormality of the distal phalanx of the thumb (HP:0009617)1.84136386
83Myopathic facies (HP:0002058)1.83757971
84Hypopigmentation of the fundus (HP:0007894)1.83174522
85Asymmetry of the thorax (HP:0001555)1.83049658
86Annular pancreas (HP:0001734)1.82525742
87Ectopic kidney (HP:0000086)1.81786658
88Easy fatigability (HP:0003388)1.81502965
89Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80039516
90Polygenic inheritance (HP:0010982)1.79785463
91Neoplasm of the oral cavity (HP:0100649)1.77676027
92Onion bulb formation (HP:0003383)1.76789271
93Deep palmar crease (HP:0006191)1.76074003
94Supernumerary bones of the axial skeleton (HP:0009144)1.75183470
95Thin ribs (HP:0000883)1.75119010
96Glioma (HP:0009733)1.74258180
97Blue sclerae (HP:0000592)1.73551834
98Disproportionate tall stature (HP:0001519)1.73370962
99Broad palm (HP:0001169)1.73134545
100Increased variability in muscle fiber diameter (HP:0003557)1.72896710
101Advanced eruption of teeth (HP:0006288)1.72735463
102Premature skin wrinkling (HP:0100678)1.72437146
103Thoracic kyphosis (HP:0002942)1.72024816
104Arnold-Chiari malformation (HP:0002308)1.71513821
105Spina bifida occulta (HP:0003298)1.71360822
106Reticulocytosis (HP:0001923)1.71190273
107Enlarged penis (HP:0000040)1.69994227
108Abnormality of the ischium (HP:0003174)1.69826995
109Increased cerebral lipofuscin (HP:0011813)1.69805168
110Bundle branch block (HP:0011710)1.68501041
111Mesomelia (HP:0003027)1.68473323
112Mildly elevated creatine phosphokinase (HP:0008180)1.68370689
113Prominent nose (HP:0000448)1.67878806
114Megalocornea (HP:0000485)1.67189502
115Increased density of long bones (HP:0006392)1.66492418
116Increased neuronal autofluorescent lipopigment (HP:0002074)1.66163982
117Aneurysm (HP:0002617)1.65672858
118Supernumerary nipples (HP:0002558)1.65568713
119Abnormality of the antihelix (HP:0009738)1.65357148
120Distal lower limb muscle weakness (HP:0009053)1.63902910
121Vertebral compression fractures (HP:0002953)1.62414504
122Spinal cord lesions (HP:0100561)1.62324272
123Syringomyelia (HP:0003396)1.62324272
124Lymphangioma (HP:0100764)1.60499900
125Genu recurvatum (HP:0002816)1.59706117
126Buphthalmos (HP:0000557)1.59046911
127Eczematoid dermatitis (HP:0000976)1.58346955
128Broad metatarsal (HP:0001783)1.58336199
129Broad thumb (HP:0011304)1.57889675
130Abnormality of the carotid arteries (HP:0005344)1.57593449
131Patellar dislocation (HP:0002999)1.56371852
132Scapular winging (HP:0003691)1.55847788
133Natal tooth (HP:0000695)1.55714160
134Ankyloglossia (HP:0010296)1.55383737
135Deep venous thrombosis (HP:0002625)1.55213759
136Acute lymphatic leukemia (HP:0006721)1.55064819
137Smooth philtrum (HP:0000319)1.54567033
138Abnormal vertebral ossification (HP:0100569)1.54144184
139EMG: neuropathic changes (HP:0003445)1.53954737
140Milia (HP:0001056)1.52816222
141Leiomyosarcoma (HP:0100243)1.52393441
142Uterine leiomyosarcoma (HP:0002891)1.52393441
143Inflammation of the large intestine (HP:0002037)1.52025013
144Bowing of the arm (HP:0006488)1.51803297
145Bowed forearm bones (HP:0003956)1.51803297
146Narrow palate (HP:0000189)1.51349673
147Selective tooth agenesis (HP:0001592)1.51152836
148Bowel incontinence (HP:0002607)1.50494038
149Difficulty climbing stairs (HP:0003551)1.50211508
150Coxa vara (HP:0002812)1.50118943
151Large earlobe (HP:0009748)1.49948050
152Nuclear cataract (HP:0100018)1.49704960
153Vertebral arch anomaly (HP:0008438)1.49521815
154Midline defect of the nose (HP:0004122)1.49488301
155Abnormality of the renal collecting system (HP:0004742)1.47250131
156Sacral dimple (HP:0000960)1.47197185
157Abnormality of the labia minora (HP:0012880)1.46854001
158Resting tremor (HP:0002322)1.46750187
159Abnormal number of incisors (HP:0011064)1.46723438
160Sandal gap (HP:0001852)1.46179454
161Abnormality of oral frenula (HP:0000190)1.44649245
162Hemiplegia (HP:0002301)1.42098889
163Frequent falls (HP:0002359)1.41105003
164High anterior hairline (HP:0009890)1.41096121
165Mitral valve prolapse (HP:0001634)1.40549159

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.56714124
2EEF2K3.67380582
3SMG13.65571361
4ICK3.15336160
5PRPF4B3.09494619
6TRIB32.93090351
7SIK22.83330733
8PKN22.72146407
9CAMK1G2.66490149
10MAP3K102.60411467
11BRD42.60075406
12TTN2.37840986
13CAMK1D2.21676931
14ALK1.99712193
15IRAK31.91751968
16SIK11.82321989
17PRKD31.75620391
18LATS11.75590159
19PTK61.67182249
20EPHA21.60835569
21MTOR1.59601629
22TYRO31.57401777
23PDGFRA1.54911645
24RIPK11.52359940
25MAP3K131.48652119
26MARK21.40369295
27MAP2K31.37867552
28MST1R1.34347089
29EPHB11.30775788
30MAP3K71.27819967
31RIPK41.27714756
32BMX1.23951784
33NEK21.22074817
34PNCK1.19547553
35MAP3K91.18278882
36CDC42BPA1.14902024
37CDC71.12032182
38DMPK1.11121917
39PAK61.06532776
40NME21.04806798
41WNK11.02371695
42FGFR21.01412739
43NTRK30.97105381
44STK380.95378568
45MAPK110.94919775
46NTRK20.94633186
47IRAK40.93973061
48RPS6KA20.93014850
49TTK0.92016526
50TAOK10.91413590
51PAK20.90353690
52MAP3K140.89421390
53PDPK10.88192802
54KSR20.85544904
55MAP2K20.85459323
56PDGFRB0.84753898
57LATS20.83790454
58PRKCH0.82775163
59CDK40.81126781
60DDR20.79318716
61MAP3K10.79293158
62RPS6KC10.78790483
63RPS6KL10.78790483
64FGFR40.78112001
65PRKD20.78035338
66TAOK20.77333137
67PTK20.77263548
68CHEK10.76934141
69MAP3K110.74575007
70TBK10.72779781
71TYK20.72233358
72MAP3K60.70886090
73PASK0.69838013
74INSRR0.69261327
75HCK0.68857109
76STK110.68288947
77SGK30.67379757
78ERN10.67107802
79RET0.66526279
80ZAP700.66384751
81UHMK10.66045380
82FGFR10.65948249
83CDK60.65230012
84AKT20.64268907
85SIK30.64169571
86RPS6KA60.63381008
87MAP3K80.61786666
88MAP3K40.61031804
89CSNK1D0.60500208
90PKN10.59581114
91JAK30.59335568
92CAMK40.58955685
93CLK10.58074157
94ATR0.57261191
95MAP4K10.55793637
96MAPK120.54934791
97STK30.54864717
98PDK10.54526008
99SGK10.54030183
100CSF1R0.53843737
101TNK20.53356184
102PAK40.53091451
103BTK0.52346287
104ATM0.52151603
105CDK20.51573004
106RPS6KB20.51311093
107CAMKK10.51120509
108MAPK140.50734764
109CSNK1E0.50348754
110GSK3B0.50346402
111PRKAA20.49919633
112EPHA40.49694784
113CHUK0.49446936
114STK40.49433159
115MAPK100.49239865
116HIPK20.48817811
117FES0.47934657
118CDK90.47564651
119MET0.47390530
120PRKDC0.47348750
121DAPK20.44579939
122PRKD10.44279782
123CDK10.44177123
124FGFR30.44133850
125MAP3K30.44077350
126PRKAA10.43652387
127MAP2K60.43018927
128NTRK10.42233207
129ERBB20.42124538
130MAPK70.41822946
131CDK70.41407694
132JAK10.41396906
133AKT10.41080915
134EPHB20.40632031
135LRRK20.40081287
136BLK0.40071989
137PHKG20.39692133
138PHKG10.39692133
139LMTK20.39344990
140RPS6KA10.39088510
141IRAK20.38943245
142* MAPK80.38813132
143BRAF0.35840620
144MAPKAPK20.35440097
145MELK0.32636613
146PRKG20.32233503
147MAPK150.30963186
148STK100.30803922

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.49344422
2Other glycan degradation_Homo sapiens_hsa005112.35083851
3Type II diabetes mellitus_Homo sapiens_hsa049301.81716858
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.67235215
5Dorso-ventral axis formation_Homo sapiens_hsa043201.65309515
6Cyanoamino acid metabolism_Homo sapiens_hsa004601.57603794
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.56360258
8Basal cell carcinoma_Homo sapiens_hsa052171.49351489
9mTOR signaling pathway_Homo sapiens_hsa041501.45219169
10Chronic myeloid leukemia_Homo sapiens_hsa052201.44439649
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.36474562
12MicroRNAs in cancer_Homo sapiens_hsa052061.31345081
13Notch signaling pathway_Homo sapiens_hsa043301.29545725
14Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29132478
15Thyroid hormone signaling pathway_Homo sapiens_hsa049191.25483051
16Dilated cardiomyopathy_Homo sapiens_hsa054141.23987395
17Glioma_Homo sapiens_hsa052141.21650006
18Fructose and mannose metabolism_Homo sapiens_hsa000511.19907755
19Estrogen signaling pathway_Homo sapiens_hsa049151.19427868
20Axon guidance_Homo sapiens_hsa043601.17462826
21Non-small cell lung cancer_Homo sapiens_hsa052231.17107245
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16815867
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16794016
24Osteoclast differentiation_Homo sapiens_hsa043801.15983984
25Glucagon signaling pathway_Homo sapiens_hsa049221.13616039
26Thyroid cancer_Homo sapiens_hsa052161.13286019
27Prion diseases_Homo sapiens_hsa050201.12081230
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11739998
29Hedgehog signaling pathway_Homo sapiens_hsa043401.10868254
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10245710
31Toxoplasmosis_Homo sapiens_hsa051451.09973573
32Adherens junction_Homo sapiens_hsa045201.09549881
33Phospholipase D signaling pathway_Homo sapiens_hsa040721.09327848
34Influenza A_Homo sapiens_hsa051641.09063272
35Pentose phosphate pathway_Homo sapiens_hsa000301.09047525
36* mRNA surveillance pathway_Homo sapiens_hsa030151.08976406
37Focal adhesion_Homo sapiens_hsa045101.08556447
38Hepatitis B_Homo sapiens_hsa051611.08028354
39Longevity regulating pathway - mammal_Homo sapiens_hsa042111.07859010
40AMPK signaling pathway_Homo sapiens_hsa041521.07822544
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.07782417
42ErbB signaling pathway_Homo sapiens_hsa040121.07470062
43Proteoglycans in cancer_Homo sapiens_hsa052051.06732110
44Leishmaniasis_Homo sapiens_hsa051401.06645654
45Insulin resistance_Homo sapiens_hsa049311.05804609
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.05326542
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.04492840
48Central carbon metabolism in cancer_Homo sapiens_hsa052301.04174094
49Endometrial cancer_Homo sapiens_hsa052131.03837962
50Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03331090
51Hepatitis C_Homo sapiens_hsa051601.02144148
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01009235
53TNF signaling pathway_Homo sapiens_hsa046681.00854999
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.99036179
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98764433
56Small cell lung cancer_Homo sapiens_hsa052220.96813711
57Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96694484
58Hippo signaling pathway_Homo sapiens_hsa043900.96576480
59Oxytocin signaling pathway_Homo sapiens_hsa049210.96410495
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.96245968
61Apoptosis_Homo sapiens_hsa042100.96172306
62Inositol phosphate metabolism_Homo sapiens_hsa005620.95481732
63Insulin secretion_Homo sapiens_hsa049110.94907081
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93959543
65VEGF signaling pathway_Homo sapiens_hsa043700.93683728
66GnRH signaling pathway_Homo sapiens_hsa049120.92677382
67Insulin signaling pathway_Homo sapiens_hsa049100.92452665
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91695825
69ECM-receptor interaction_Homo sapiens_hsa045120.90909425
70Choline metabolism in cancer_Homo sapiens_hsa052310.90884256
71Long-term potentiation_Homo sapiens_hsa047200.90785489
72Gastric acid secretion_Homo sapiens_hsa049710.90239111
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89081982
74Glutamatergic synapse_Homo sapiens_hsa047240.88362643
75MAPK signaling pathway_Homo sapiens_hsa040100.87764387
76Renal cell carcinoma_Homo sapiens_hsa052110.87539916
77Acute myeloid leukemia_Homo sapiens_hsa052210.87514252
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87455940
79Wnt signaling pathway_Homo sapiens_hsa043100.86338947
80Melanogenesis_Homo sapiens_hsa049160.85964437
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.85145833
82Cocaine addiction_Homo sapiens_hsa050300.84902623
83Nitrogen metabolism_Homo sapiens_hsa009100.84727556
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83547630
85B cell receptor signaling pathway_Homo sapiens_hsa046620.83464043
86Morphine addiction_Homo sapiens_hsa050320.82877182
87Nicotine addiction_Homo sapiens_hsa050330.82795940
88cAMP signaling pathway_Homo sapiens_hsa040240.81940851
89Rap1 signaling pathway_Homo sapiens_hsa040150.81938937
90Viral myocarditis_Homo sapiens_hsa054160.81643823
91Herpes simplex infection_Homo sapiens_hsa051680.81250666
92One carbon pool by folate_Homo sapiens_hsa006700.80525920
93Pancreatic cancer_Homo sapiens_hsa052120.78793414
94Fatty acid biosynthesis_Homo sapiens_hsa000610.78057176
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77965923
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75382944
97Amphetamine addiction_Homo sapiens_hsa050310.74952843
98Colorectal cancer_Homo sapiens_hsa052100.74688993
99Measles_Homo sapiens_hsa051620.74325974
100T cell receptor signaling pathway_Homo sapiens_hsa046600.73959510
101Calcium signaling pathway_Homo sapiens_hsa040200.73208325
102HTLV-I infection_Homo sapiens_hsa051660.73147716
103Salivary secretion_Homo sapiens_hsa049700.72463873
104Taste transduction_Homo sapiens_hsa047420.72322319
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.71954617
106Renin secretion_Homo sapiens_hsa049240.71062033
107Cholinergic synapse_Homo sapiens_hsa047250.71036210
108Olfactory transduction_Homo sapiens_hsa047400.70712024
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70416122
110Viral carcinogenesis_Homo sapiens_hsa052030.70372120
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70086619
112HIF-1 signaling pathway_Homo sapiens_hsa040660.69786897
113Gap junction_Homo sapiens_hsa045400.69397082
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69385879
115Bladder cancer_Homo sapiens_hsa052190.69059791
116Prostate cancer_Homo sapiens_hsa052150.68308982
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68106336
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67764768
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67599526
120Prolactin signaling pathway_Homo sapiens_hsa049170.66961266
121Amoebiasis_Homo sapiens_hsa051460.65525918
122Pathways in cancer_Homo sapiens_hsa052000.65466763
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.64338921
124Protein digestion and absorption_Homo sapiens_hsa049740.64326325
125Tuberculosis_Homo sapiens_hsa051520.63954643
126Endocytosis_Homo sapiens_hsa041440.63389144
127Systemic lupus erythematosus_Homo sapiens_hsa053220.62838124
128Alcoholism_Homo sapiens_hsa050340.62652049
129Circadian entrainment_Homo sapiens_hsa047130.62192993
130Epstein-Barr virus infection_Homo sapiens_hsa051690.61940637
131Sulfur relay system_Homo sapiens_hsa041220.61925635
132Galactose metabolism_Homo sapiens_hsa000520.60690511
133Platelet activation_Homo sapiens_hsa046110.60346910
134Biosynthesis of amino acids_Homo sapiens_hsa012300.59078971
135Primary immunodeficiency_Homo sapiens_hsa053400.54612280
136FoxO signaling pathway_Homo sapiens_hsa040680.53969632
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53763706
138Chemokine signaling pathway_Homo sapiens_hsa040620.53147279
139Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52026552
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51034062
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.45770010

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