SYCE3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.99340969
2sperm-egg recognition (GO:0035036)9.92317649
3acrosome reaction (GO:0007340)9.42846486
4binding of sperm to zona pellucida (GO:0007339)9.35734991
5cell-cell recognition (GO:0009988)8.89368989
6male meiosis (GO:0007140)8.75113896
7spermatid development (GO:0007286)8.67647316
8* synaptonemal complex assembly (GO:0007130)8.51444964
9multicellular organism reproduction (GO:0032504)8.47200209
10* synaptonemal complex organization (GO:0070193)8.37120015
11epithelial cilium movement (GO:0003351)8.02555902
12plasma membrane fusion (GO:0045026)7.98464910
13axonemal dynein complex assembly (GO:0070286)7.97590394
14cilium or flagellum-dependent cell motility (GO:0001539)7.65866654
15reproduction (GO:0000003)7.43242316
16motile cilium assembly (GO:0044458)7.34427207
17DNA methylation involved in gamete generation (GO:0043046)7.27012124
18cilium movement (GO:0003341)6.50162944
19regulation of cilium movement (GO:0003352)6.49080777
20male meiosis I (GO:0007141)6.25429030
21meiotic nuclear division (GO:0007126)6.21013690
22* spermatogenesis (GO:0007283)6.14061441
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.13174975
24* chromosome organization involved in meiosis (GO:0070192)6.12615469
25* male gamete generation (GO:0048232)6.12377870
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.82809906
27microtubule depolymerization (GO:0007019)5.74912639
28single fertilization (GO:0007338)5.73056163
29negative regulation of inclusion body assembly (GO:0090084)5.69574343
30* gamete generation (GO:0007276)5.64218060
31sperm capacitation (GO:0048240)5.61367332
32establishment of protein localization to mitochondrial membrane (GO:0090151)5.57044553
33germ cell development (GO:0007281)5.37922136
34fertilization (GO:0009566)5.34469746
35meiosis I (GO:0007127)5.26644205
36chromosome condensation (GO:0030261)5.16401691
37DNA packaging (GO:0006323)5.15290613
38cellular process involved in reproduction in multicellular organism (GO:0022412)5.09406647
39spermatid nucleus differentiation (GO:0007289)5.04120547
40mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.98689705
41organic cation transport (GO:0015695)4.97820111
42ATP synthesis coupled proton transport (GO:0015986)4.91794009
43energy coupled proton transport, down electrochemical gradient (GO:0015985)4.91794009
44regulation of inclusion body assembly (GO:0090083)4.87627731
45single strand break repair (GO:0000012)4.84966165
46positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.52217671
47respiratory electron transport chain (GO:0022904)4.44585401
48brain morphogenesis (GO:0048854)4.39157697
49peptidyl-histidine modification (GO:0018202)4.39078946
50* multicellular organismal reproductive process (GO:0048609)4.38836820
51regulation of mitochondrial translation (GO:0070129)4.36169866
52electron transport chain (GO:0022900)4.35958060
53chaperone-mediated protein transport (GO:0072321)4.26271262
54calcium ion-dependent exocytosis (GO:0017156)4.24320767
55microtubule severing (GO:0051013)4.20321536
56chaperone-mediated protein complex assembly (GO:0051131)4.20233375
57seminiferous tubule development (GO:0072520)4.12697256
58regulation of meiosis I (GO:0060631)4.11761352
59* meiotic cell cycle process (GO:1903046)4.09161424
60cell recognition (GO:0008037)4.08701574
61ventricular system development (GO:0021591)4.00407818
62meiotic cell cycle (GO:0051321)3.97758950
63amyloid precursor protein catabolic process (GO:0042987)3.96412550
64regulation of microtubule-based movement (GO:0060632)3.84733486
65synapsis (GO:0007129)3.82174830
66sexual reproduction (GO:0019953)3.79389689
67gene silencing by RNA (GO:0031047)3.78532819
68positive regulation of response to oxidative stress (GO:1902884)3.77204289
69positive regulation of cellular response to oxidative stress (GO:1900409)3.77204289
70glycerol ether metabolic process (GO:0006662)3.71784792
71proteasome assembly (GO:0043248)3.71771992
72regulation of spindle checkpoint (GO:0090231)3.65039092
73monoubiquitinated protein deubiquitination (GO:0035520)3.63562438
74histone exchange (GO:0043486)3.61958319
75protein K11-linked deubiquitination (GO:0035871)3.51650952
76protein complex biogenesis (GO:0070271)3.48252938
77cellular ketone body metabolic process (GO:0046950)3.47874828
78multicellular organismal development (GO:0007275)3.45386221
79nucleus organization (GO:0006997)3.43605666
80ether metabolic process (GO:0018904)3.42446112
81beta-amyloid metabolic process (GO:0050435)3.42051026
82L-phenylalanine catabolic process (GO:0006559)3.39280356
83erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.39280356
84inner mitochondrial membrane organization (GO:0007007)3.38747972
85sequestering of actin monomers (GO:0042989)3.38257565
86nuclear pore complex assembly (GO:0051292)3.38205874
87membrane protein intracellular domain proteolysis (GO:0031293)3.37392974
88genitalia morphogenesis (GO:0035112)3.35030166
89aggressive behavior (GO:0002118)3.33508304
90photoreceptor cell maintenance (GO:0045494)3.27443016
91gene silencing (GO:0016458)3.26675144
92sister chromatid cohesion (GO:0007062)3.26432656
93nonmotile primary cilium assembly (GO:0035058)3.23017228
94rRNA methylation (GO:0031167)3.22060111
95hydrogen ion transmembrane transport (GO:1902600)3.20008496
96positive regulation of prostaglandin secretion (GO:0032308)3.19648629
97chromatin silencing (GO:0006342)3.19077625
98left/right pattern formation (GO:0060972)3.17975107
99rRNA modification (GO:0000154)3.17910994
100regulation of centriole replication (GO:0046599)3.17476603
101mitotic sister chromatid cohesion (GO:0007064)3.16973205
102DNA methylation (GO:0006306)3.16053526
103DNA alkylation (GO:0006305)3.16053526
104mitochondrial respiratory chain complex assembly (GO:0033108)3.13923935
105DNA synthesis involved in DNA repair (GO:0000731)3.13631992
106nuclear pore organization (GO:0006999)3.09798683
107microtubule polymerization or depolymerization (GO:0031109)3.08928954
108protein K6-linked ubiquitination (GO:0085020)3.07387311
109DNA replication-dependent nucleosome assembly (GO:0006335)3.05972192
110DNA replication-dependent nucleosome organization (GO:0034723)3.05972192
111ketone body metabolic process (GO:1902224)3.02599852
112heterochromatin organization (GO:0070828)3.01686492
113negative regulation of execution phase of apoptosis (GO:1900118)3.00766936
114dopamine biosynthetic process (GO:0042416)2.94802029
115proton transport (GO:0015992)2.94023748
116L-phenylalanine metabolic process (GO:0006558)2.93537985
117erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.93537985
118somite rostral/caudal axis specification (GO:0032525)2.91902917
119positive regulation of histone H3-K4 methylation (GO:0051571)2.91486570
120regulation of histone H3-K9 methylation (GO:0051570)2.90797641
121protein polyglutamylation (GO:0018095)2.90261986
122protein localization to chromosome, centromeric region (GO:0071459)2.87889052
123protein refolding (GO:0042026)2.86853805
124histone H2A acetylation (GO:0043968)2.84592972
125hydrogen transport (GO:0006818)2.84392068
126regulation of mitotic spindle checkpoint (GO:1903504)2.82565355
127regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.82565355
128nitric oxide biosynthetic process (GO:0006809)2.81294998
129hyperosmotic salinity response (GO:0042538)2.81074871
130histone H4-K12 acetylation (GO:0043983)2.76563363
131interferon-gamma secretion (GO:0072643)2.75479511
132* chromosome organization (GO:0051276)2.75195902
133regulation of female receptivity (GO:0045924)2.75091282
134ATP biosynthetic process (GO:0006754)2.74972980
135resolution of meiotic recombination intermediates (GO:0000712)2.74802725
136dorsal/ventral neural tube patterning (GO:0021904)2.74459359
137regulation of type B pancreatic cell apoptotic process (GO:2000674)2.74256032
138protein localization to Golgi apparatus (GO:0034067)2.73269902
139endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.73132812
140mismatch repair (GO:0006298)2.72185101
141protein localization to cilium (GO:0061512)2.70981158
142endocrine pancreas development (GO:0031018)2.70821052
143regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.70704685
144transcription elongation from RNA polymerase III promoter (GO:0006385)2.70176878
145termination of RNA polymerase III transcription (GO:0006386)2.70176878
146GTP biosynthetic process (GO:0006183)2.69097491
147nucleoside diphosphate phosphorylation (GO:0006165)2.68496360
148deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.66739539
149ribosomal small subunit assembly (GO:0000028)2.66374608
150L-alpha-amino acid transmembrane transport (GO:1902475)2.64717932
151sensory perception of smell (GO:0007608)2.64529975
152ncRNA 3-end processing (GO:0043628)2.64517741
153protein-DNA complex disassembly (GO:0032986)2.63675508
154nucleosome disassembly (GO:0006337)2.63675508
155purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.63366513
156regulation of protein glycosylation (GO:0060049)2.62979492
157pore complex assembly (GO:0046931)2.62829660
158negative regulation of organelle assembly (GO:1902116)2.61651013
159neuromuscular process controlling posture (GO:0050884)2.59470016
160sex differentiation (GO:0007548)2.59301532
161purine nucleoside triphosphate biosynthetic process (GO:0009145)2.58858940
162intracellular protein transmembrane import (GO:0044743)2.58506386
163cilium morphogenesis (GO:0060271)2.58022501
164protein targeting to Golgi (GO:0000042)2.57019006
165oogenesis (GO:0048477)2.56807544
166positive regulation of macrophage activation (GO:0043032)2.55641114
167glandular epithelial cell differentiation (GO:0002067)2.55304571
168pteridine-containing compound biosynthetic process (GO:0042559)2.54455632
169NADH metabolic process (GO:0006734)2.54069855
170* reciprocal DNA recombination (GO:0035825)2.54040747
171oxidative phosphorylation (GO:0006119)2.52451778
172respiratory chain complex IV assembly (GO:0008535)2.51173418
173regulation of helicase activity (GO:0051095)2.50624440
174* reciprocal meiotic recombination (GO:0007131)2.50247076
175glutathione derivative biosynthetic process (GO:1901687)2.49547382
176glutathione derivative metabolic process (GO:1901685)2.49547382
177cellular response to exogenous dsRNA (GO:0071360)2.47271983
178cell wall macromolecule catabolic process (GO:0016998)11.4014995
179cell wall macromolecule metabolic process (GO:0044036)11.4014995
180sperm motility (GO:0030317)11.3113146
181fusion of sperm to egg plasma membrane (GO:0007342)10.6100887
182acrosome assembly (GO:0001675)10.1394382

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.14928794
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.04093811
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.41637700
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.98797933
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.47570040
6GBX2_23144817_ChIP-Seq_PC3_Human3.20351918
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.19152072
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.97938581
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.76948508
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.65511193
11EZH2_22144423_ChIP-Seq_EOC_Human2.63332551
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.53425557
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.45422017
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.37670560
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.34899738
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.24379228
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21172690
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.12718154
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10363114
20ELK1_19687146_ChIP-ChIP_HELA_Human2.04363206
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.9740060
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94178102
23FOXM1_23109430_ChIP-Seq_U2OS_Human1.93180103
24FUS_26573619_Chip-Seq_HEK293_Human1.90372622
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89444577
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84510016
27E2F7_22180533_ChIP-Seq_HELA_Human1.82759206
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80759277
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76501354
30KAP1_22055183_ChIP-Seq_ESCs_Mouse1.74546322
31VDR_22108803_ChIP-Seq_LS180_Human1.72668709
32KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.70434278
33FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65231693
34VDR_23849224_ChIP-Seq_CD4+_Human1.64210128
35EWS_26573619_Chip-Seq_HEK293_Human1.63729039
36GATA3_21867929_ChIP-Seq_CD8_Mouse1.62857675
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.61231208
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.59917944
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59005591
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.58186368
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57792605
42HTT_18923047_ChIP-ChIP_STHdh_Human1.55285205
43TP53_22573176_ChIP-Seq_HFKS_Human1.55230505
44MYC_18940864_ChIP-ChIP_HL60_Human1.54754932
45RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.54594998
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53652745
47SOX2_22085726_ChIP-Seq_NPCs_Mouse1.51396028
48TAF15_26573619_Chip-Seq_HEK293_Human1.50592829
49EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.49720048
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49712210
51ELK4_26923725_Chip-Seq_MESODERM_Mouse1.49341799
52STAT1_17558387_ChIP-Seq_HELA_Human1.49267362
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46823812
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44008515
55SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.40186159
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38506237
57ER_23166858_ChIP-Seq_MCF-7_Human1.38502241
58GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.36512963
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.35951337
60TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.34308147
61ZNF274_21170338_ChIP-Seq_K562_Hela1.33340576
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31864593
63GATA3_21867929_ChIP-Seq_TH1_Mouse1.31754272
64DCP1A_22483619_ChIP-Seq_HELA_Human1.31062942
65P300_19829295_ChIP-Seq_ESCs_Human1.30851632
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.30133559
67FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29096623
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28211857
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28191525
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.28191525
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25132427
72BCAT_22108803_ChIP-Seq_LS180_Human1.25128234
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23602504
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23174996
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22856217
76RUNX1_26923725_Chip-Seq_HPCs_Mouse1.22417081
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21880388
78IGF1R_20145208_ChIP-Seq_DFB_Human1.21221872
79YY1_22570637_ChIP-Seq_MALME-3M_Human1.20744864
80WDR5_24793694_ChIP-Seq_LNCAP_Human1.20661652
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19959488
82NANOG_19829295_ChIP-Seq_ESCs_Human1.19242553
83SOX2_19829295_ChIP-Seq_ESCs_Human1.19242553
84LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.18966084
85P53_21459846_ChIP-Seq_SAOS-2_Human1.18662758
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17029729
87SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16555570
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16246489
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.15999475
90SMAD4_21799915_ChIP-Seq_A2780_Human1.15797323
91SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14781354
92AR_20517297_ChIP-Seq_VCAP_Human1.13169330
93LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12735487
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.11919765
95RARA_24833708_ChIP-Seq_LIVER_Mouse1.11571993
96MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11411527
97RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10455524
98FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08335472
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07847735
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07169957
101SPI1_26923725_Chip-Seq_HPCs_Mouse1.06875030
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05994949
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04319307
104NOTCH1_21737748_ChIP-Seq_TLL_Human1.04314498
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03753708
106CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03379296
107CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03375297
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01975479
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01375184
110AR_21909140_ChIP-Seq_LNCAP_Human1.00065365
111SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99855157
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99413501
113MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99239602
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97715928
115SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97203663
116FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96232442
117FLI1_21867929_ChIP-Seq_CD8_Mouse0.95742659
118TET1_21451524_ChIP-Seq_MESCs_Mouse0.95431755
119POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95295103
120ESET_19884257_ChIP-Seq_ESCs_Mouse0.95054539
121RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94422993
122RNF2_27304074_Chip-Seq_NSC_Mouse0.94410580
123CBX2_27304074_Chip-Seq_ESCs_Mouse0.94230007
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93824454
125PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93438891
126ERG_20517297_ChIP-Seq_VCAP_Human0.93418832
127TTF2_22483619_ChIP-Seq_HELA_Human0.92963992
128FOXP3_21729870_ChIP-Seq_TREG_Human0.92611947
129MYC_18555785_ChIP-Seq_MESCs_Mouse0.92533594
130GF1_26923725_Chip-Seq_HPCs_Mouse0.92314529
131IRF1_19129219_ChIP-ChIP_H3396_Human0.91962040
132KDM2B_26808549_Chip-Seq_REH_Human0.91338261
133CRX_20693478_ChIP-Seq_RETINA_Mouse0.90039018
134PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89974338
135SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89677629
136TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89281529
137MYC_19829295_ChIP-Seq_ESCs_Human0.89142875
138PHF8_20622854_ChIP-Seq_HELA_Human0.88911070
139SALL1_21062744_ChIP-ChIP_HESCs_Human0.88240104
140MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88046604
141NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.87984375
142RUNX2_22187159_ChIP-Seq_PCA_Human0.87163150
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86817996
144RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86677407
145SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86602106
146EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86531984
147CBP_20019798_ChIP-Seq_JUKART_Human0.85963685
148IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85963685
149FLI1_21867929_ChIP-Seq_TH2_Mouse0.85420375
150HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85420259
151OCT4_18555785_Chip-Seq_ESCs_Mouse0.85301818
152FOXH1_21741376_ChIP-Seq_EPCs_Human0.85018338
153ELK1_22589737_ChIP-Seq_MCF10A_Human0.84858357
154NANOG_16153702_ChIP-ChIP_HESCs_Human0.84657296
155ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84574667
156TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84514458
157RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84415042
158NANOG_18555785_Chip-Seq_ESCs_Mouse0.84324847
159SOX2_21211035_ChIP-Seq_LN229_Human0.84201882
160NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.83432123
161TCF4_23295773_ChIP-Seq_U87_Human0.83339667
162TCF4_22108803_ChIP-Seq_LS180_Human0.83321158
163PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82875581
164CTCF_26484167_Chip-Seq_Bcells_Mouse0.82462131
165AR_25329375_ChIP-Seq_VCAP_Human0.82123747
166JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.81661888
167SOX11_22085726_ChIP-Seq_ESNs_Mouse0.81008522
168FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.80943761
169NCOR_22424771_ChIP-Seq_293T_Human0.80634078
170SMAD4_21741376_ChIP-Seq_EPCs_Human0.80459412
171STAT3_18555785_ChIP-Seq_MESCs_Mouse0.80023674
172ELF1_20517297_ChIP-Seq_JURKAT_Human0.79974671
173MYC_19079543_ChIP-ChIP_MESCs_Mouse0.79639698
174SOX2_16153702_ChIP-ChIP_HESCs_Human0.78501078
175KLF5_20875108_ChIP-Seq_MESCs_Mouse0.78006598
176ETV2_25802403_ChIP-Seq_MESCs_Mouse0.77752591
177GATA3_21878914_ChIP-Seq_MCF-7_Human0.77606487
178STAT3_18555785_Chip-Seq_ESCs_Mouse0.76272319
179STAT3_23295773_ChIP-Seq_U87_Human0.76183507

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.86199702
2MP0003698_abnormal_male_reproductive5.73756117
3MP0001929_abnormal_gametogenesis5.70980646
4MP0002210_abnormal_sex_determination4.30135644
5MP0006292_abnormal_olfactory_placode3.91925646
6MP0001145_abnormal_male_reproductive3.61261403
7MP0002837_dystrophic_cardiac_calcinosis3.44655104
8MP0004270_analgesia3.38408170
9MP0002139_abnormal_hepatobiliary_system3.25297845
10MP0002161_abnormal_fertility/fecundity3.17606078
11MP0000653_abnormal_sex_gland3.15908102
12MP0003880_abnormal_central_pattern2.78684005
13MP0005379_endocrine/exocrine_gland_phen2.78069533
14MP0006072_abnormal_retinal_apoptosis2.74427158
15MP0008058_abnormal_DNA_repair2.70808529
16MP0010094_abnormal_chromosome_stability2.43281776
17MP0008995_early_reproductive_senescence2.31629384
18MP0008057_abnormal_DNA_replication2.29755459
19MP0002277_abnormal_respiratory_mucosa2.29272289
20MP0000013_abnormal_adipose_tissue2.13073735
21MP0010386_abnormal_urinary_bladder2.03748625
22MP0002163_abnormal_gland_morphology2.01749169
23MP0005410_abnormal_fertilization13.1229753
24MP0002160_abnormal_reproductive_system1.97323334
25MP0002653_abnormal_ependyma_morphology1.95855784
26MP0005646_abnormal_pituitary_gland1.95721427
27MP0003111_abnormal_nucleus_morphology1.95107649
28MP0000631_abnormal_neuroendocrine_gland1.93451729
29MP0003786_premature_aging1.90649718
30MP0004147_increased_porphyrin_level1.89682654
31MP0005670_abnormal_white_adipose1.88676056
32MP0001529_abnormal_vocalization1.74189356
33MP0003693_abnormal_embryo_hatching1.68807880
34MP0005645_abnormal_hypothalamus_physiol1.68068464
35MP0003136_yellow_coat_color1.65143190
36MP0003077_abnormal_cell_cycle1.53642649
37MP0002909_abnormal_adrenal_gland1.53126551
38MP0003122_maternal_imprinting1.52118175
39MP0005551_abnormal_eye_electrophysiolog1.51261403
40MP0004957_abnormal_blastocyst_morpholog1.50645543
41MP0004043_abnormal_pH_regulation1.49577477
42MP0001944_abnormal_pancreas_morphology1.43427637
43MP0006276_abnormal_autonomic_nervous1.41511165
44MP0004742_abnormal_vestibular_system1.41339746
45MP0002734_abnormal_mechanical_nocicepti1.39270353
46MP0001485_abnormal_pinna_reflex1.36346010
47MP0003646_muscle_fatigue1.32475962
48MP0002693_abnormal_pancreas_physiology1.28206422
49MP0008007_abnormal_cellular_replicative1.27086651
50MP0009379_abnormal_foot_pigmentation1.23558771
51MP0005187_abnormal_penis_morphology1.17096493
52MP0001730_embryonic_growth_arrest1.15908070
53MP0005623_abnormal_meninges_morphology1.15670259
54MP0003123_paternal_imprinting1.12901533
55MP0004233_abnormal_muscle_weight1.12182512
56MP0000427_abnormal_hair_cycle1.09041539
57MP0002272_abnormal_nervous_system1.07806503
58MP0008789_abnormal_olfactory_epithelium1.06837262
59MP0005389_reproductive_system_phenotype1.05444152
60MP0003283_abnormal_digestive_organ1.04216164
61MP0003195_calcinosis1.03584425
62MP0008872_abnormal_physiological_respon1.02884434
63MP0005332_abnormal_amino_acid1.00735271
64MP0010307_abnormal_tumor_latency0.99742528
65MP0002254_reproductive_system_inflammat0.99182132
66MP0003186_abnormal_redox_activity0.97430195
67MP0002557_abnormal_social/conspecific_i0.93239991
68MP0009745_abnormal_behavioral_response0.92924261
69MP0010329_abnormal_lipoprotein_level0.92589057
70MP0001756_abnormal_urination0.92440763
71MP0000647_abnormal_sebaceous_gland0.92214652
72MP0005647_abnormal_sex_gland0.91545646
73MP0003878_abnormal_ear_physiology0.89483211
74MP0005377_hearing/vestibular/ear_phenot0.89483211
75MP0001119_abnormal_female_reproductive0.89180631
76MP0003252_abnormal_bile_duct0.88129985
77MP0005220_abnormal_exocrine_pancreas0.87186188
78MP0002078_abnormal_glucose_homeostasis0.86273427
79MP0008932_abnormal_embryonic_tissue0.85888779
80MP0001919_abnormal_reproductive_system0.85358540
81MP0001293_anophthalmia0.83010209
82MP0002229_neurodegeneration0.82506466
83MP0002876_abnormal_thyroid_physiology0.82501934
84MP0002295_abnormal_pulmonary_circulatio0.80780520
85MP0005058_abnormal_lysosome_morphology0.80759611
86MP0002572_abnormal_emotion/affect_behav0.79927680
87MP0003699_abnormal_female_reproductive0.79437855
88MP0003879_abnormal_hair_cell0.76928960
89MP0003806_abnormal_nucleotide_metabolis0.76807730
90MP0002735_abnormal_chemical_nociception0.74194050
91MP0004885_abnormal_endolymph0.73024404
92MP0002064_seizures0.72509808
93MP0004215_abnormal_myocardial_fiber0.72255684
94MP0003718_maternal_effect0.71335357
95MP0001672_abnormal_embryogenesis/_devel0.70931484
96MP0005380_embryogenesis_phenotype0.70931484
97MP0002090_abnormal_vision0.70782601
98MP0000566_synostosis0.70617292
99MP0001968_abnormal_touch/_nociception0.70083010
100MP0002233_abnormal_nose_morphology0.70070569
101MP0002638_abnormal_pupillary_reflex0.70067010
102MP0000313_abnormal_cell_death0.69121532
103MP0005408_hypopigmentation0.68502583
104MP0001697_abnormal_embryo_size0.68215871
105MP0000350_abnormal_cell_proliferation0.68054958
106MP0004133_heterotaxia0.66955323
107MP0002067_abnormal_sensory_capabilities0.65204029
108MP0004808_abnormal_hematopoietic_stem0.64863424
109MP0001905_abnormal_dopamine_level0.64394884
110MP0002084_abnormal_developmental_patter0.63984214
111MP0000372_irregular_coat_pigmentation0.63918208
112MP0003633_abnormal_nervous_system0.63602149
113MP0000358_abnormal_cell_content/0.63413483
114MP0006036_abnormal_mitochondrial_physio0.61868114
115MP0003984_embryonic_growth_retardation0.61387933
116MP0002085_abnormal_embryonic_tissue0.61033707
117MP0002234_abnormal_pharynx_morphology0.59593091
118MP0002282_abnormal_trachea_morphology0.57974267
119MP0002088_abnormal_embryonic_growth/wei0.57527993
120MP0002080_prenatal_lethality0.55822757
121MP0001984_abnormal_olfaction0.55593180
122MP0003115_abnormal_respiratory_system0.52376528
123MP0001765_abnormal_ion_homeostasis0.51661025
124MP0004197_abnormal_fetal_growth/weight/0.51339440
125MP0001545_abnormal_hematopoietic_system0.49417392
126MP0005397_hematopoietic_system_phenotyp0.49417392
127MP0002269_muscular_atrophy0.47214244
128MP0003315_abnormal_perineum_morphology0.46773916
129MP0009672_abnormal_birth_weight0.46361286
130MP0003890_abnormal_embryonic-extraembry0.43575770
131MP0001764_abnormal_homeostasis0.43004041
132MP0006035_abnormal_mitochondrial_morpho0.39715985
133MP0003936_abnormal_reproductive_system0.39691131
134MP0003861_abnormal_nervous_system0.38439912
135MP0005391_vision/eye_phenotype0.38380362
136MP0002019_abnormal_tumor_incidence0.37910942
137MP0003950_abnormal_plasma_membrane0.36259670
138MP0001986_abnormal_taste_sensitivity0.36079838
139MP0003119_abnormal_digestive_system0.35544541
140MP0002086_abnormal_extraembryonic_tissu0.35008852
141MP0005253_abnormal_eye_physiology0.33901595
142MP0002092_abnormal_eye_morphology0.33701814
143MP0005666_abnormal_adipose_tissue0.32600045
144MP0009046_muscle_twitch0.31649439
145MP0004036_abnormal_muscle_relaxation0.30939264
146MP0004019_abnormal_vitamin_homeostasis0.30004761
147MP0009703_decreased_birth_body0.28786372
148MP0005266_abnormal_metabolism0.27710080
149MP0005636_abnormal_mineral_homeostasis0.27031225
150MP0001661_extended_life_span0.27002943
151MP0002169_no_abnormal_phenotype0.26152690
152MP0003121_genomic_imprinting0.26147048
153MP0001849_ear_inflammation0.26028735
154MP0002873_normal_phenotype0.25720480
155MP0009278_abnormal_bone_marrow0.25433234
156MP0003011_delayed_dark_adaptation0.25014107
157MP0001324_abnormal_eye_pigmentation0.24546439
158MP0005395_other_phenotype0.24091009
159MP0003787_abnormal_imprinting0.23353748
160MP0000432_abnormal_head_morphology0.23218339
161MP0000534_abnormal_ureter_morphology0.22965669
162MP0001727_abnormal_embryo_implantation0.22950735
163MP0004145_abnormal_muscle_electrophysio0.20957324
164MP0002132_abnormal_respiratory_system0.19858397
165MP0000001_mammalian_phenotype0.18894797
166MP0002697_abnormal_eye_size0.17888334
167MP0005384_cellular_phenotype0.17229330

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.74299294
2Abnormal respiratory motile cilium morphology (HP:0005938)8.33982321
3Abnormal respiratory epithelium morphology (HP:0012253)8.33982321
4Rhinitis (HP:0012384)7.36895217
5Chronic bronchitis (HP:0004469)7.30569475
6Abnormal ciliary motility (HP:0012262)6.83020211
7Infertility (HP:0000789)6.34434408
8Nasal polyposis (HP:0100582)5.64910040
9Abnormal spermatogenesis (HP:0008669)5.25168519
103-Methylglutaconic aciduria (HP:0003535)4.62224015
11Abnormality of the nasal mucosa (HP:0000433)4.53451170
12Azoospermia (HP:0000027)4.53183660
13Male infertility (HP:0003251)4.28490492
14Bronchiectasis (HP:0002110)4.21667640
15Abnormality of aromatic amino acid family metabolism (HP:0004338)4.19700294
16Bronchitis (HP:0012387)4.18916488
17Nephronophthisis (HP:0000090)4.05990861
18Acute necrotizing encephalopathy (HP:0006965)3.98691044
19Postural tremor (HP:0002174)3.90432736
20Acute encephalopathy (HP:0006846)3.63108216
21Mitochondrial inheritance (HP:0001427)3.62972526
22Hypothermia (HP:0002045)3.61918071
23Intestinal atresia (HP:0011100)3.61376218
24Generalized aminoaciduria (HP:0002909)3.59814356
25Increased hepatocellular lipid droplets (HP:0006565)3.54308556
26Septo-optic dysplasia (HP:0100842)3.41603747
27Progressive macrocephaly (HP:0004481)3.41355829
28Abnormal mitochondria in muscle tissue (HP:0008316)3.39740138
29Hepatocellular necrosis (HP:0001404)3.38231472
30Hepatic necrosis (HP:0002605)3.24485886
31Impulsivity (HP:0100710)3.20297763
32Renal Fanconi syndrome (HP:0001994)3.19214169
33Lipid accumulation in hepatocytes (HP:0006561)3.11276411
34Gonadotropin excess (HP:0000837)3.07530920
35Recurrent otitis media (HP:0000403)2.98170833
36Abnormality of the renal medulla (HP:0100957)2.97120339
37Increased CSF lactate (HP:0002490)2.96232588
38Abnormality of the lower motor neuron (HP:0002366)2.88437735
39Decreased activity of mitochondrial respiratory chain (HP:0008972)2.87286020
40Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.87286020
41Recurrent sinusitis (HP:0011108)2.85001341
42Constricted visual fields (HP:0001133)2.84751444
43Renal cortical cysts (HP:0000803)2.79171055
44Nephrogenic diabetes insipidus (HP:0009806)2.76662320
45Abnormality of midbrain morphology (HP:0002418)2.74626637
46Molar tooth sign on MRI (HP:0002419)2.74626637
47Horizontal nystagmus (HP:0000666)2.72909847
48Tubulointerstitial nephritis (HP:0001970)2.66653388
49Tubular atrophy (HP:0000092)2.65954116
50Aplasia/Hypoplasia of the fovea (HP:0008060)2.63570856
51Hypoplasia of the fovea (HP:0007750)2.63570856
52Nuclear cataract (HP:0100018)2.59549807
53Attenuation of retinal blood vessels (HP:0007843)2.57239501
54Progressive cerebellar ataxia (HP:0002073)2.51741575
55Glycosuria (HP:0003076)2.49884905
56Abnormality of urine glucose concentration (HP:0011016)2.49884905
57Limb dystonia (HP:0002451)2.49463982
58Medial flaring of the eyebrow (HP:0010747)2.41849710
59Respiratory failure (HP:0002878)2.41202545
60Syncope (HP:0001279)2.40403035
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.40057890
62Abnormal protein N-linked glycosylation (HP:0012347)2.40057890
63Abnormal protein glycosylation (HP:0012346)2.40057890
64Abnormal glycosylation (HP:0012345)2.40057890
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.38095068
66Type I transferrin isoform profile (HP:0003642)2.31019487
67Cerebral edema (HP:0002181)2.30357904
68Abnormality of renal resorption (HP:0011038)2.30307721
69Genital tract atresia (HP:0001827)2.29039710
70Optic disc pallor (HP:0000543)2.25820742
71Decreased testicular size (HP:0008734)2.25246405
72Facial cleft (HP:0002006)2.25073066
73Tubulointerstitial abnormality (HP:0001969)2.24398396
74Lactic acidosis (HP:0003128)2.23027491
75Vaginal atresia (HP:0000148)2.21963119
76Fibular hypoplasia (HP:0003038)2.15288253
77Supernumerary spleens (HP:0009799)2.14741053
78Poor coordination (HP:0002370)2.13160859
79Vacuolated lymphocytes (HP:0001922)2.11240349
80Recurrent bronchitis (HP:0002837)2.11147831
81Testicular atrophy (HP:0000029)2.10667929
82Postaxial foot polydactyly (HP:0001830)2.10513497
83Amyotrophic lateral sclerosis (HP:0007354)2.09554193
84Poor suck (HP:0002033)2.07099390
85Colon cancer (HP:0003003)2.06757435
86Increased intramyocellular lipid droplets (HP:0012240)2.04811331
87Bony spicule pigmentary retinopathy (HP:0007737)2.04232980
88Abnormality of fatty-acid metabolism (HP:0004359)2.02820224
89Maternal diabetes (HP:0009800)2.00736772
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.4941550
91Dynein arm defect of respiratory motile cilia (HP:0012255)11.7836455
92Absent/shortened dynein arms (HP:0200106)11.7836455
93Focal dystonia (HP:0004373)1.94061188
94Degeneration of anterior horn cells (HP:0002398)1.93724241
95Abnormality of the anterior horn cell (HP:0006802)1.93724241
96Abnormality of the fovea (HP:0000493)1.93199165
97Limb hypertonia (HP:0002509)1.91727877
98Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91698710
99Increased CSF protein (HP:0002922)1.90404442
100Retinitis pigmentosa (HP:0000510)1.90077543
101Respiratory difficulties (HP:0002880)1.89938904
102Hypoalbuminemia (HP:0003073)1.87265954
103Abnormal albumin level (HP:0012116)1.87265954
104Gaze-evoked nystagmus (HP:0000640)1.85718954
105Pancreatic fibrosis (HP:0100732)1.85389608
106Gastrointestinal atresia (HP:0002589)1.82385040
107Sensorimotor neuropathy (HP:0007141)1.82117011
108Abnormality of dental color (HP:0011073)1.81633702
109Degeneration of the lateral corticospinal tracts (HP:0002314)1.81421052
110Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.81421052
111Short ribs (HP:0000773)1.81248115
112Asplenia (HP:0001746)1.81144056
113Exertional dyspnea (HP:0002875)1.80700555
114Chromsome breakage (HP:0040012)1.80029701
115Abnormal biliary tract morphology (HP:0012440)1.79101218
116Abnormality of vitamin B metabolism (HP:0004340)1.78878675
117Resting tremor (HP:0002322)1.77420781
118Myokymia (HP:0002411)1.76996482
119Congenital hepatic fibrosis (HP:0002612)1.76966067
120Prolonged partial thromboplastin time (HP:0003645)1.76538096
121Stage 5 chronic kidney disease (HP:0003774)1.76132435
122Tubulointerstitial fibrosis (HP:0005576)1.75304618
123Hypoplasia of the capital femoral epiphysis (HP:0003090)1.71906973
124Double outlet right ventricle (HP:0001719)1.71182154
125Congenital malformation of the right heart (HP:0011723)1.71182154
126Oculomotor apraxia (HP:0000657)1.69001814
12711 pairs of ribs (HP:0000878)1.67343550
128Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.66116939
129Abnormal drinking behavior (HP:0030082)1.62026682
130Polydipsia (HP:0001959)1.62026682
131Microglossia (HP:0000171)1.58194798
132Carpal bone hypoplasia (HP:0001498)1.57524168
133Median cleft lip (HP:0000161)1.55751275
134Abnormality of the renal cortex (HP:0011035)1.55233402
135Tongue fasciculations (HP:0001308)1.54198349
136Cystic liver disease (HP:0006706)1.52806044
137Selective tooth agenesis (HP:0001592)1.52407488
138Upper motor neuron abnormality (HP:0002127)1.51587733
139Dyschromatopsia (HP:0007641)1.50946526
140Renal dysplasia (HP:0000110)1.49453605
141Cleft eyelid (HP:0000625)1.48642151
142Breast carcinoma (HP:0003002)1.48420051
143Aplasia/Hypoplasia of the tongue (HP:0010295)1.48382868
144Abnormality of renal excretion (HP:0011036)1.46720865
145Postaxial hand polydactyly (HP:0001162)1.46511695
146Aplasia/Hypoplasia of the fibula (HP:0006492)1.45290721
147Transposition of the great arteries (HP:0001669)1.43361559
148Abnormal connection of the cardiac segments (HP:0011545)1.43361559
149Abnormal ventriculo-arterial connection (HP:0011563)1.43361559
150Heterotopia (HP:0002282)1.42779231
151Spastic tetraparesis (HP:0001285)1.42142549
152Pancreatic cysts (HP:0001737)1.42019703
153Impaired proprioception (HP:0010831)1.40495679
154Sloping forehead (HP:0000340)1.38821693
155Ectopic kidney (HP:0000086)1.38174446
156Abnormality of permanent molar morphology (HP:0011071)1.37955344
157Abnormality of the dental root (HP:0006486)1.37955344
158Taurodontia (HP:0000679)1.37955344
159True hermaphroditism (HP:0010459)1.36108002
160Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.35807514
161Muscle fibrillation (HP:0010546)1.34753531
162Optic nerve hypoplasia (HP:0000609)1.33526485
163Bile duct proliferation (HP:0001408)1.31304051
164Abnormal biliary tract physiology (HP:0012439)1.31304051
165Absent epiphyses (HP:0010577)1.29573375
166Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.29573375
167Decreased central vision (HP:0007663)1.29569520
168Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.28619762
169Abnormality of ocular smooth pursuit (HP:0000617)1.27691227
170Occipital encephalocele (HP:0002085)1.27618446
171Congenital primary aphakia (HP:0007707)1.26835575
172Type 2 muscle fiber atrophy (HP:0003554)1.25629227
173Abnormality of the dental pulp (HP:0006479)1.25319631
174Abnormality of molar (HP:0011077)1.24937460
175Abnormality of molar morphology (HP:0011070)1.24937460
176Absent thumb (HP:0009777)1.24686024
177Short thorax (HP:0010306)1.23596230
178Gait imbalance (HP:0002141)1.23019935
179Abnormal gallbladder physiology (HP:0012438)1.22667201

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.37573067
2PDK48.37573067
3PDK25.53341439
4TESK15.09978406
5MST43.69061726
6CSNK1G13.53004302
7EPHA43.48630397
8PRKD33.35266210
9ICK3.25182623
10CSNK1G33.23632361
11CASK3.10815172
12CSNK1A1L2.90173790
13CSNK1G22.74988796
14PHKG22.37666582
15PHKG12.37666582
16VRK22.29806027
17GRK12.27427523
18NEK22.18600273
19WEE12.05098732
20MAP3K121.94735409
21CDK191.91873261
22CDC71.88148801
23PTK2B1.77705963
24MAP4K21.76085128
25MET1.71780625
26ACVR1B1.67342911
27FRK1.63731389
28WNK41.62227483
29STK391.59776672
30STK381.48023911
31PNCK1.45741024
32TAOK31.43187779
33OXSR11.41851347
34TAF11.38515691
35TTK1.36141847
36TNK21.32108560
37TLK11.31383730
38MAP3K91.27844840
39ERBB31.26846505
40DYRK31.26798735
41NTRK31.16716854
42STK38L1.13883329
43BRSK21.11162961
44PINK11.10791666
45VRK11.03655810
46BMX1.03254508
47PLK41.00918275
48DYRK1B1.00559600
49CHEK21.00128240
50PLK10.99028084
51CCNB10.97355715
52NUAK10.96987008
53PAK30.96796455
54BUB10.96416739
55NLK0.94592403
56PDK10.94121768
57CDK120.90627055
58MAPKAPK30.90084048
59GRK50.89328552
60ATR0.88777577
61EIF2AK10.88540310
62PASK0.87221295
63IRAK10.86904260
64PRKCE0.84679846
65CHEK10.84551358
66DAPK10.84475569
67FGR0.83079920
68STK30.79753190
69PRKCI0.78155458
70TYRO30.75818412
71SRPK10.74843238
72PIK3CA0.69647328
73BRSK10.66535692
74CSNK1A10.65240875
75UHMK10.60522455
76MAPK130.59540966
77ATM0.58933980
78INSRR0.58532126
79IRAK20.57338734
80ADRBK20.54902231
81TAOK10.54270390
82DAPK20.53701786
83WNK10.51536982
84FER0.50254138
85PLK20.50036530
86LIMK10.49952188
87PLK30.49596696
88ARAF0.47855810
89PDPK10.47647061
90STK240.46622965
91PTK20.45787741
92CSF1R0.44386160
93GRK70.44095543
94PBK0.43531343
95LMTK20.42856027
96MAPK150.42632981
97EIF2AK30.42611289
98PAK10.41525758
99TESK20.41359622
100AURKA0.40557616
101MAP2K60.37867472
102STK110.37853831
103AURKB0.37838489
104STK160.37251262
105NEK10.35997132
106CDK20.35279057
107TSSK60.33587449
108MTOR0.33357821
109PRKG20.33016037
110CDK70.32185473
111BRAF0.32062514
112MOS0.31376968
113DYRK20.31275281
114MATK0.29807992
115CLK10.29348524
116PAK40.29120389
117CDK10.29051884
118STK40.28731145
119CAMK2A0.28191142
120CSNK2A10.28133006
121CDK40.27661074
122PRKG10.27467151
123NEK60.27336338
124PRKD20.27088627
125CSNK2A20.26654508
126MELK0.26080820
127PRKCG0.24972389
128MKNK20.23488294
129EEF2K0.22710325
130PIM10.21023310
131CDK60.20633981
132MARK30.19533985
133WNK30.18516781
134PRKAA10.17512830
135RPS6KB10.16909142
136MKNK10.16168915
137GSK3B0.14704569
138STK100.12995707
139ZAK0.11540846
140MAPK80.11227870
141EIF2AK20.10374082
142PRKDC0.10009292
143CDC42BPA0.09970977
144BRD40.09894815
145CSNK1E0.09440884
146NTRK20.09292050
147MAP3K80.09289210
148RIPK40.09178403
149PRKCZ0.07264807
150CDK150.06346831
151RPS6KA10.06280367
152MAP3K40.06169743
153EPHA20.05432820
154CSNK1D0.04713223
155AKT30.04602290
156CDK11A0.04425427
157CDK180.04406069
158ALK0.04077079
159BMPR1B0.03232203
160CDK140.02680626

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.81093699
2Basal transcription factors_Homo sapiens_hsa030224.07628701
3Parkinsons disease_Homo sapiens_hsa050123.90182067
4Vitamin B6 metabolism_Homo sapiens_hsa007503.78019903
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.18691477
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.08200493
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.91822150
8Alzheimers disease_Homo sapiens_hsa050102.90847364
9Folate biosynthesis_Homo sapiens_hsa007902.88777873
10Fanconi anemia pathway_Homo sapiens_hsa034602.82330518
11Fatty acid biosynthesis_Homo sapiens_hsa000612.76009783
12RNA transport_Homo sapiens_hsa030132.68971945
13Pyruvate metabolism_Homo sapiens_hsa006202.60546463
14Linoleic acid metabolism_Homo sapiens_hsa005912.59956872
15DNA replication_Homo sapiens_hsa030302.59083271
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.55425103
17Selenocompound metabolism_Homo sapiens_hsa004502.48732890
18Protein export_Homo sapiens_hsa030602.34009614
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.25560505
20Pentose phosphate pathway_Homo sapiens_hsa000302.21068019
21Homologous recombination_Homo sapiens_hsa034402.20017253
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.18848362
23Oocyte meiosis_Homo sapiens_hsa041142.17302195
24Proteasome_Homo sapiens_hsa030502.12763773
25mRNA surveillance pathway_Homo sapiens_hsa030152.10603800
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03300621
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97936301
28Mismatch repair_Homo sapiens_hsa034301.94923095
29Spliceosome_Homo sapiens_hsa030401.81967207
30Pyrimidine metabolism_Homo sapiens_hsa002401.80461671
31Cell cycle_Homo sapiens_hsa041101.78493959
32Purine metabolism_Homo sapiens_hsa002301.74977871
33Glucagon signaling pathway_Homo sapiens_hsa049221.74420135
34Propanoate metabolism_Homo sapiens_hsa006401.71736180
35RNA polymerase_Homo sapiens_hsa030201.57730795
36Nucleotide excision repair_Homo sapiens_hsa034201.46246101
37Base excision repair_Homo sapiens_hsa034101.46214791
38Butanoate metabolism_Homo sapiens_hsa006501.46178944
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45504317
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44215885
41Glycerophospholipid metabolism_Homo sapiens_hsa005641.43517777
42Huntingtons disease_Homo sapiens_hsa050161.43492708
43Glycerolipid metabolism_Homo sapiens_hsa005611.42045355
44Fat digestion and absorption_Homo sapiens_hsa049751.41571674
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40113378
46Peroxisome_Homo sapiens_hsa041461.40057055
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38082940
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.36870781
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33586173
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33398352
51Regulation of autophagy_Homo sapiens_hsa041401.28991735
52Fructose and mannose metabolism_Homo sapiens_hsa000511.28517302
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28399094
54Carbon metabolism_Homo sapiens_hsa012001.28300850
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22204637
56Fatty acid elongation_Homo sapiens_hsa000621.21608817
57Glutathione metabolism_Homo sapiens_hsa004801.21188740
58RNA degradation_Homo sapiens_hsa030181.19531708
59Nitrogen metabolism_Homo sapiens_hsa009101.18183250
60Ether lipid metabolism_Homo sapiens_hsa005651.17651705
61Non-homologous end-joining_Homo sapiens_hsa034501.16561363
62Biosynthesis of amino acids_Homo sapiens_hsa012301.15531759
63Phenylalanine metabolism_Homo sapiens_hsa003601.15171888
64Carbohydrate digestion and absorption_Homo sapiens_hsa049731.15118699
65Dorso-ventral axis formation_Homo sapiens_hsa043201.09409242
66Tyrosine metabolism_Homo sapiens_hsa003501.09407974
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08013234
68Sphingolipid metabolism_Homo sapiens_hsa006001.03874919
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03298556
70N-Glycan biosynthesis_Homo sapiens_hsa005101.01281987
71Mineral absorption_Homo sapiens_hsa049781.01075778
72Steroid biosynthesis_Homo sapiens_hsa001000.97043059
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95085088
74Antigen processing and presentation_Homo sapiens_hsa046120.93959363
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.93149703
76Caffeine metabolism_Homo sapiens_hsa002320.92583936
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.87107510
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86017725
79Cardiac muscle contraction_Homo sapiens_hsa042600.84638767
80Vibrio cholerae infection_Homo sapiens_hsa051100.84307155
81beta-Alanine metabolism_Homo sapiens_hsa004100.83387111
82PPAR signaling pathway_Homo sapiens_hsa033200.83168362
83Arginine and proline metabolism_Homo sapiens_hsa003300.82126697
84Insulin secretion_Homo sapiens_hsa049110.80571371
85Circadian rhythm_Homo sapiens_hsa047100.79053189
86Systemic lupus erythematosus_Homo sapiens_hsa053220.78766900
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77779217
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77378779
89Epstein-Barr virus infection_Homo sapiens_hsa051690.76672173
90Arachidonic acid metabolism_Homo sapiens_hsa005900.75597564
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74502186
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73497835
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71412504
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67832090
95Amphetamine addiction_Homo sapiens_hsa050310.67103152
96Retinol metabolism_Homo sapiens_hsa008300.65954790
97Fatty acid degradation_Homo sapiens_hsa000710.64855749
98Chemical carcinogenesis_Homo sapiens_hsa052040.64669807
99Fatty acid metabolism_Homo sapiens_hsa012120.64013646
100Other glycan degradation_Homo sapiens_hsa005110.61766525
101Dopaminergic synapse_Homo sapiens_hsa047280.61357484
102Hedgehog signaling pathway_Homo sapiens_hsa043400.61317137
103Synaptic vesicle cycle_Homo sapiens_hsa047210.59846405
104p53 signaling pathway_Homo sapiens_hsa041150.59683284
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59443982
106Long-term depression_Homo sapiens_hsa047300.57831280
107Phototransduction_Homo sapiens_hsa047440.56636525
108Renin-angiotensin system_Homo sapiens_hsa046140.56165469
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55928419
110ABC transporters_Homo sapiens_hsa020100.55719409
111Serotonergic synapse_Homo sapiens_hsa047260.53647270
112Glutamatergic synapse_Homo sapiens_hsa047240.53149030
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51824845
114Metabolic pathways_Homo sapiens_hsa011000.48450315
115Taste transduction_Homo sapiens_hsa047420.48335573
116Ribosome_Homo sapiens_hsa030100.48282991
117Olfactory transduction_Homo sapiens_hsa047400.46501741
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45596208
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42871289
120Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42280835
121Viral carcinogenesis_Homo sapiens_hsa052030.42105345
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.38366685
123Histidine metabolism_Homo sapiens_hsa003400.37377641
124Nicotine addiction_Homo sapiens_hsa050330.37249818
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36993325
126Tryptophan metabolism_Homo sapiens_hsa003800.36873008
127One carbon pool by folate_Homo sapiens_hsa006700.35158804
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31793996
129Legionellosis_Homo sapiens_hsa051340.31713450
130Herpes simplex infection_Homo sapiens_hsa051680.31111330
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30513228
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27731350
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25725286
134Collecting duct acid secretion_Homo sapiens_hsa049660.23977337
135AMPK signaling pathway_Homo sapiens_hsa041520.22923918
136Alcoholism_Homo sapiens_hsa050340.19998563
137Inositol phosphate metabolism_Homo sapiens_hsa005620.19155420
138Long-term potentiation_Homo sapiens_hsa047200.17435881
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16910718
140Renin secretion_Homo sapiens_hsa049240.15968577
141Drug metabolism - other enzymes_Homo sapiens_hsa009830.14934709
142HTLV-I infection_Homo sapiens_hsa051660.14515775
143cGMP-PKG signaling pathway_Homo sapiens_hsa040220.13886374
144Estrogen signaling pathway_Homo sapiens_hsa049150.13319557
145Vitamin digestion and absorption_Homo sapiens_hsa049770.13019642
146HIF-1 signaling pathway_Homo sapiens_hsa040660.11357243
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.11322703
148Thyroid hormone synthesis_Homo sapiens_hsa049180.11191936
149Wnt signaling pathway_Homo sapiens_hsa043100.09557758
150Protein digestion and absorption_Homo sapiens_hsa049740.09283408
151Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.07806436
152Endocytosis_Homo sapiens_hsa041440.07611921

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