SWT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)5.33087323
2monoubiquitinated protein deubiquitination (GO:0035520)4.80743292
3interleukin-6-mediated signaling pathway (GO:0070102)4.71125490
4neural tube formation (GO:0001841)4.69291809
5kinetochore assembly (GO:0051382)4.38700742
6cell wall macromolecule metabolic process (GO:0044036)4.35424115
7positive regulation of mitochondrial fission (GO:0090141)4.24663796
8kinetochore organization (GO:0051383)4.17610405
9meiotic chromosome segregation (GO:0045132)4.00491056
10Notch signaling involved in heart development (GO:0061314)3.94451855
11superoxide anion generation (GO:0042554)3.93670967
12negative regulation of DNA-dependent DNA replication (GO:2000104)3.91805610
13hepatocyte apoptotic process (GO:0097284)3.88108661
14tyrosine phosphorylation of STAT protein (GO:0007260)3.84219097
15protein K6-linked ubiquitination (GO:0085020)3.83457065
16interkinetic nuclear migration (GO:0022027)3.79338827
17epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.71728767
18regulation of development, heterochronic (GO:0040034)3.70524455
19microtubule depolymerization (GO:0007019)3.67661738
20protein prenylation (GO:0018342)3.61050003
21prenylation (GO:0097354)3.61050003
22centriole assembly (GO:0098534)3.59173735
23regulation of mitochondrial fission (GO:0090140)3.58907141
24protein polyglutamylation (GO:0018095)3.58689656
25peroxisome fission (GO:0016559)3.57837287
26positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.52640649
27establishment of protein localization to Golgi (GO:0072600)3.48393760
28mitotic metaphase plate congression (GO:0007080)3.48232821
29olfactory bulb development (GO:0021772)3.48101881
30positive regulation of cardiac muscle cell differentiation (GO:2000727)3.47960763
31mitotic G2 DNA damage checkpoint (GO:0007095)3.47772232
32peptidyl-lysine trimethylation (GO:0018023)3.41921179
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.41618569
34ventricular trabecula myocardium morphogenesis (GO:0003222)3.40875067
35female gonad development (GO:0008585)3.35434586
36spermatid nucleus differentiation (GO:0007289)3.33996992
37CENP-A containing nucleosome assembly (GO:0034080)3.33345114
38mitotic G2/M transition checkpoint (GO:0044818)3.31755309
39protein targeting to Golgi (GO:0000042)3.29842797
40DNA integration (GO:0015074)3.28767553
41secondary heart field specification (GO:0003139)3.25103794
42heart field specification (GO:0003128)3.25103794
43metaphase plate congression (GO:0051310)3.24988476
44limb bud formation (GO:0060174)3.21338399
45preassembly of GPI anchor in ER membrane (GO:0016254)3.19684011
46regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.19162660
47retrograde transport, vesicle recycling within Golgi (GO:0000301)3.18953147
48regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.16289592
49chromatin remodeling at centromere (GO:0031055)3.15962573
50keratinocyte development (GO:0003334)3.14666668
51centriole replication (GO:0007099)3.14260754
52DNA demethylation (GO:0080111)3.13889382
53regulation of nuclear cell cycle DNA replication (GO:0033262)3.13007104
54dentate gyrus development (GO:0021542)3.12252056
55DNA methylation involved in gamete generation (GO:0043046)3.08699049
56negative regulation of response to food (GO:0032096)3.07876866
57negative regulation of appetite (GO:0032099)3.07876866
58inflammatory response to antigenic stimulus (GO:0002437)3.06085369
59DNA synthesis involved in DNA repair (GO:0000731)3.04619700
60mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.02809475
61piRNA metabolic process (GO:0034587)3.02484755
62reciprocal meiotic recombination (GO:0007131)3.02393317
63reciprocal DNA recombination (GO:0035825)3.02393317
64intraciliary transport (GO:0042073)3.00182305
65rRNA methylation (GO:0031167)2.96884047
66microglial cell activation (GO:0001774)2.94949362
67positive regulation of vascular permeability (GO:0043117)2.93674203
68phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.93636062
69epithelial cell fate commitment (GO:0072148)2.92514219
70adaptation of signaling pathway (GO:0023058)2.87101262
71replicative senescence (GO:0090399)2.86508184
72drinking behavior (GO:0042756)2.83217099
73rRNA modification (GO:0000154)2.80450484
74energy homeostasis (GO:0097009)2.80248825
75cytokine secretion (GO:0050663)2.79454299
76potassium ion export (GO:0071435)2.79083625
77DNA dealkylation (GO:0035510)2.79006886
78histone mRNA catabolic process (GO:0071044)2.76945216
79heart trabecula morphogenesis (GO:0061384)2.76219759
80negative regulation of mast cell activation (GO:0033004)2.75167323
81protein K11-linked deubiquitination (GO:0035871)2.73105209
82negative regulation of keratinocyte proliferation (GO:0010839)2.73060243
83maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.72986986
84histone H2B ubiquitination (GO:0033523)2.72788241
85GPI anchor biosynthetic process (GO:0006506)2.71280211
86regulation of protein glycosylation (GO:0060049)2.71197463
87forebrain neuron differentiation (GO:0021879)2.69725785
88snRNA transcription (GO:0009301)2.69635357
89mitochondrion degradation (GO:0000422)2.69252676
90necroptotic process (GO:0070266)2.68658782
91male meiosis I (GO:0007141)2.67816442
92establishment of chromosome localization (GO:0051303)2.67352489
93neutrophil mediated immunity (GO:0002446)2.65719016
94cellular response to ethanol (GO:0071361)2.65365646
95detection of molecule of bacterial origin (GO:0032490)2.64444710
96mesenchymal cell differentiation involved in renal system development (GO:2001012)2.64308237
97mesenchymal cell differentiation involved in kidney development (GO:0072161)2.64308237
98positive regulation of toll-like receptor signaling pathway (GO:0034123)2.64097061
99G-protein coupled receptor internalization (GO:0002031)2.63495911
100photoreceptor cell maintenance (GO:0045494)2.62750285
101DNA strand renaturation (GO:0000733)2.61725414
102poly(A)+ mRNA export from nucleus (GO:0016973)2.61648947
103DNA replication-independent nucleosome organization (GO:0034724)2.60239451
104DNA replication-independent nucleosome assembly (GO:0006336)2.60239451
105termination of RNA polymerase I transcription (GO:0006363)2.60095827
106DNA ligation (GO:0006266)2.59121214
107transcription elongation from RNA polymerase I promoter (GO:0006362)2.58471716
108axonemal dynein complex assembly (GO:0070286)2.57782051
109histone exchange (GO:0043486)2.56625562
110negative regulation of transcription by competitive promoter binding (GO:0010944)2.55464038
111tRNA methylation (GO:0030488)2.55207603
112positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.55069972
113B cell differentiation (GO:0030183)2.53061731
114negative regulation of myoblast differentiation (GO:0045662)2.51911745
115necrotic cell death (GO:0070265)2.51623075
116cellular response to gamma radiation (GO:0071480)2.51586933
117positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.50077584
118regulation of mast cell activation (GO:0033003)2.50036448
119protein localization to Golgi apparatus (GO:0034067)2.49688442
120response to X-ray (GO:0010165)2.49637503
121lateral ventricle development (GO:0021670)2.49625467
122regulation of double-strand break repair via homologous recombination (GO:0010569)2.49468304
123detection of light stimulus involved in sensory perception (GO:0050962)2.49424161
124detection of light stimulus involved in visual perception (GO:0050908)2.49424161
125regulation of helicase activity (GO:0051095)2.48730842
126negative regulation of digestive system process (GO:0060457)2.48005764
127regulation of B cell receptor signaling pathway (GO:0050855)2.47809634
128neurotransmitter catabolic process (GO:0042135)2.47416565
129regulation of non-canonical Wnt signaling pathway (GO:2000050)2.46825834
130DNA replication checkpoint (GO:0000076)2.46441742
131mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.46232939
132positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.46232939
133mitochondrial fission (GO:0000266)2.45771025
134GPI anchor metabolic process (GO:0006505)2.45109063
135sphingoid metabolic process (GO:0046519)2.44764782
136regulation of meiosis I (GO:0060631)2.44706162
137indolalkylamine metabolic process (GO:0006586)2.44663962
138pericardium development (GO:0060039)2.44588930
139regulation of heat generation (GO:0031650)2.44150321
140regulation of interleukin-6 biosynthetic process (GO:0045408)2.44026310
141histone H3-K36 demethylation (GO:0070544)2.42635725
142cellular response to interleukin-6 (GO:0071354)2.42549777
143N-glycan processing (GO:0006491)2.41766345
144regulation of chromatin silencing (GO:0031935)2.41139068
145presynaptic membrane assembly (GO:0097105)2.40629416
146cellular extravasation (GO:0045123)2.40307523
147cilium assembly (GO:0042384)2.39866085
148cilium organization (GO:0044782)2.39606437
149morphogenesis of an endothelium (GO:0003159)2.39518161
150endothelial tube morphogenesis (GO:0061154)2.39518161
151regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.38431737
152regulation of mitotic spindle checkpoint (GO:1903504)2.38431737
153mismatch repair (GO:0006298)2.37292071
154regulation of timing of cell differentiation (GO:0048505)2.37057003
155androgen biosynthetic process (GO:0006702)2.35874205
156amino sugar catabolic process (GO:0046348)2.35242703
157inner cell mass cell proliferation (GO:0001833)2.33604567
158synapsis (GO:0007129)2.33565404
159intra-S DNA damage checkpoint (GO:0031573)2.33225099
160oocyte maturation (GO:0001556)2.33185687
161cilium or flagellum-dependent cell motility (GO:0001539)2.32933309
162RNA methylation (GO:0001510)2.32805373
163epithelial cilium movement (GO:0003351)2.32701889
164DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.31956341
165DNA catabolic process, exonucleolytic (GO:0000738)2.31732757
166telomere maintenance via telomerase (GO:0007004)2.30947510
167regulation of germinal center formation (GO:0002634)2.30843273
168protein heterotetramerization (GO:0051290)2.28648858
169sphingosine metabolic process (GO:0006670)2.27509815
170lymphoid progenitor cell differentiation (GO:0002320)2.26966288
171maturation of 5.8S rRNA (GO:0000460)2.26400039
172histone H3-K4 trimethylation (GO:0080182)2.25647766
173positive regulation of interleukin-1 beta secretion (GO:0050718)2.24356575
174microtubule polymerization or depolymerization (GO:0031109)2.23745901
175detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.23664322
176DNA damage response, signal transduction resulting in transcription (GO:0042772)2.23649342
177axoneme assembly (GO:0035082)2.23357947
178regulation of DNA endoreduplication (GO:0032875)2.22593020
179male meiosis (GO:0007140)2.21195297
180microtubule anchoring (GO:0034453)2.20660190
181mannosylation (GO:0097502)2.20362922
182meiosis I (GO:0007127)2.19931690
183positive regulation of defense response to virus by host (GO:0002230)2.19715547
184cilium movement (GO:0003341)2.19576238
185dendritic cell chemotaxis (GO:0002407)2.19291970
186positive regulation of DNA-dependent DNA replication (GO:2000105)2.19270436
187transcription from RNA polymerase I promoter (GO:0006360)2.18862388
188transcription initiation from RNA polymerase I promoter (GO:0006361)2.18629235
189negative regulation of execution phase of apoptosis (GO:1900118)2.17483955
190diol metabolic process (GO:0034311)2.16593409

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PCGF2_27294783_Chip-Seq_ESCs_Mouse3.52106816
2FLI1_27457419_Chip-Seq_LIVER_Mouse3.37376674
3SUZ12_27294783_Chip-Seq_NPCs_Mouse2.94229489
4NFE2_27457419_Chip-Seq_LIVER_Mouse2.82059230
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.75421022
6PCGF2_27294783_Chip-Seq_NPCs_Mouse2.73343980
7E2F7_22180533_ChIP-Seq_HELA_Human2.67177076
8GBX2_23144817_ChIP-Seq_PC3_Human2.54146283
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.47757200
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.45309912
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.43419968
12GATA1_22025678_ChIP-Seq_K562_Human2.41955834
13EZH2_27294783_Chip-Seq_NPCs_Mouse2.39828263
14EZH2_22144423_ChIP-Seq_EOC_Human2.34147373
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.30478751
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20115829
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.13452063
18EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse2.07505932
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.02482404
20STAT3_18555785_Chip-Seq_ESCs_Mouse2.02112324
21SUZ12_18555785_Chip-Seq_ESCs_Mouse2.01398972
22NANOG_18555785_Chip-Seq_ESCs_Mouse2.00704213
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99091550
24NMYC_18555785_Chip-Seq_ESCs_Mouse1.96350970
25E2F1_18555785_Chip-Seq_ESCs_Mouse1.95643152
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95334966
27TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.94614077
28EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.92741230
29P53_22387025_ChIP-Seq_ESCs_Mouse1.92556593
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86270593
31P300_18555785_Chip-Seq_ESCs_Mouse1.85027660
32RUNX1_27457419_Chip-Seq_LIVER_Mouse1.84084475
33OCT4_18555785_Chip-Seq_ESCs_Mouse1.83575230
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.83326339
35FUS_26573619_Chip-Seq_HEK293_Human1.78566674
36EWS_26573619_Chip-Seq_HEK293_Human1.77412092
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.76484786
38IGF1R_20145208_ChIP-Seq_DFB_Human1.75488093
39ZFX_18555785_Chip-Seq_ESCs_Mouse1.75121936
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74685878
41CMYC_18555785_Chip-Seq_ESCs_Mouse1.73866461
42IRF1_19129219_ChIP-ChIP_H3396_Human1.72907541
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72022036
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.71712335
45SOX2_18555785_Chip-Seq_ESCs_Mouse1.71694148
46KLF4_18555785_Chip-Seq_ESCs_Mouse1.69166112
47KAP1_22055183_ChIP-Seq_ESCs_Mouse1.68536250
48CRX_20693478_ChIP-Seq_RETINA_Mouse1.66885044
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.66367632
50CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.66173586
51ESRRB_18555785_Chip-Seq_ESCs_Mouse1.63847469
52PU1_27457419_Chip-Seq_LIVER_Mouse1.62230151
53SMAD1_18555785_Chip-Seq_ESCs_Mouse1.61468872
54KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.60242358
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59391468
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.59347381
57OCT4_21477851_ChIP-Seq_ESCs_Mouse1.59165745
58CTCF_18555785_Chip-Seq_ESCs_Mouse1.57639546
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56760107
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.56098718
61CBP_20019798_ChIP-Seq_JUKART_Human1.51277437
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51277437
63AR_21572438_ChIP-Seq_LNCaP_Human1.50542872
64RNF2_27304074_Chip-Seq_NSC_Mouse1.50456702
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50223060
66P300_19829295_ChIP-Seq_ESCs_Human1.48112839
67SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.46890564
68VDR_22108803_ChIP-Seq_LS180_Human1.46718355
69TAL1_26923725_Chip-Seq_HPCs_Mouse1.46455388
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46303130
71TAF15_26573619_Chip-Seq_HEK293_Human1.43128993
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38877765
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38761018
74BCAT_22108803_ChIP-Seq_LS180_Human1.38460915
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35877993
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.35674690
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35625844
78ER_23166858_ChIP-Seq_MCF-7_Human1.35542015
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33787999
80IRF8_22096565_ChIP-ChIP_GC-B_Human1.32887343
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.32410039
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.31002383
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.30376485
84STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29561687
85AR_25329375_ChIP-Seq_VCAP_Human1.27072938
86ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26177561
87LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25669726
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24741238
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24612702
90FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24404129
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21769339
92RUNX2_22187159_ChIP-Seq_PCA_Human1.21753635
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19596835
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.18725154
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18141626
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17896529
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.17407342
98SOX2_19829295_ChIP-Seq_ESCs_Human1.16615005
99NANOG_19829295_ChIP-Seq_ESCs_Human1.16615005
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15957312
101STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15894722
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15892647
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15647418
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15647418
105FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13100099
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12199372
107ZNF274_21170338_ChIP-Seq_K562_Hela1.11584967
108SALL4_22934838_ChIP-ChIP_CD34+_Human1.11361105
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10940046
110TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10076278
111ELK1_19687146_ChIP-ChIP_HELA_Human1.09772682
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09749311
113HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08806525
114CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08762974
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08317581
116FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07515134
117PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07156479
118RUNX_20019798_ChIP-Seq_JUKART_Human1.05356039
119KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04147497
120TP53_16413492_ChIP-PET_HCT116_Human1.03569705
121IRF8_27001747_Chip-Seq_BMDM_Mouse1.03332973
122STAT1_17558387_ChIP-Seq_HELA_Human1.01924503
123IRF8_21731497_ChIP-ChIP_J774_Mouse1.01685934
124PHF8_20622853_ChIP-Seq_HELA_Human1.00969729
125GATA3_26560356_Chip-Seq_TH2_Human1.00766885
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99876698
127VDR_24787735_ChIP-Seq_THP-1_Human0.99813970
128SOX2_21211035_ChIP-Seq_LN229_Gbm0.99215096
129TCF4_22108803_ChIP-Seq_LS180_Human0.98913048
130SMAD4_21799915_ChIP-Seq_A2780_Human0.98396203
131CDX2_22108803_ChIP-Seq_LS180_Human0.98396110
132HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96756522
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96402812
134JUN_21703547_ChIP-Seq_K562_Human0.96365099
135KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95795260
136ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95053644
137ETV1_20927104_ChIP-Seq_GIST48_Human0.94145324
138TCF4_23295773_ChIP-Seq_U87_Human0.94032599
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93994568
140MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93116422
141CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93003289
142STAT3_23295773_ChIP-Seq_U87_Human0.92255245
143GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92245626
144NFYB_21822215_ChIP-Seq_K562_Human0.91497680
145FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89965850
146RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89849328
147RBPJ_21746931_ChIP-Seq_IB4_Human0.89296226
148MYC_18940864_ChIP-ChIP_HL60_Human0.89178130
149KDM2B_26808549_Chip-Seq_REH_Human0.88982034

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.23587995
2MP0006292_abnormal_olfactory_placode3.58631577
3MP0003136_yellow_coat_color3.52093835
4MP0001188_hyperpigmentation3.50695668
5MP0003890_abnormal_embryonic-extraembry3.33915836
6MP0008058_abnormal_DNA_repair3.13876081
7MP0003656_abnormal_erythrocyte_physiolo3.04808032
8MP0008057_abnormal_DNA_replication2.92819730
9MP0002102_abnormal_ear_morphology2.73175673
10MP0000566_synostosis2.71120050
11MP0003693_abnormal_embryo_hatching2.58152933
12MP0004381_abnormal_hair_follicle2.56558424
13MP0008995_early_reproductive_senescence2.41698372
14MP0010094_abnormal_chromosome_stability2.41133858
15MP0002277_abnormal_respiratory_mucosa2.36156192
16MP0001986_abnormal_taste_sensitivity2.26791063
17MP0003718_maternal_effect2.18765625
18MP0008877_abnormal_DNA_methylation2.16154707
19MP0002653_abnormal_ependyma_morphology2.14355871
20MP0002132_abnormal_respiratory_system2.11390408
21MP0003303_peritoneal_inflammation2.11113061
22MP0003111_abnormal_nucleus_morphology2.07485340
23MP0000371_diluted_coat_color2.03593596
24MP0000015_abnormal_ear_pigmentation1.99727806
25MP0008260_abnormal_autophagy1.98541029
26MP0003786_premature_aging1.95845123
27MP0004084_abnormal_cardiac_muscle1.82887745
28MP0005409_darkened_coat_color1.82761940
29MP0005451_abnormal_body_composition1.82666212
30MP0006054_spinal_hemorrhage1.82361861
31MP0003941_abnormal_skin_development1.81480207
32MP0000383_abnormal_hair_follicle1.79232126
33MP0003787_abnormal_imprinting1.78821111
34MP0005174_abnormal_tail_pigmentation1.73817016
35MP0005075_abnormal_melanosome_morpholog1.72988706
36MP0005171_absent_coat_pigmentation1.70750096
37MP0003221_abnormal_cardiomyocyte_apopto1.70287185
38MP0004885_abnormal_endolymph1.64527730
39MP0008789_abnormal_olfactory_epithelium1.62578583
40MP0009697_abnormal_copulation1.56255196
41MP0003077_abnormal_cell_cycle1.46377163
42MP0005671_abnormal_response_to1.45449911
43MP0002638_abnormal_pupillary_reflex1.44179573
44MP0002938_white_spotting1.43819112
45MP0002396_abnormal_hematopoietic_system1.41966276
46MP0005379_endocrine/exocrine_gland_phen1.41088712
47MP0000778_abnormal_nervous_system1.37759684
48MP0002095_abnormal_skin_pigmentation1.36787688
49MP0002210_abnormal_sex_determination1.34623836
50MP0003724_increased_susceptibility_to1.34587518
51MP0002163_abnormal_gland_morphology1.30479272
52MP0008007_abnormal_cellular_replicative1.30250596
53MP0005248_abnormal_Harderian_gland1.30109572
54MP0005464_abnormal_platelet_physiology1.29761255
55MP0005394_taste/olfaction_phenotype1.27461063
56MP0005499_abnormal_olfactory_system1.27461063
57MP0003943_abnormal_hepatobiliary_system1.26505377
58MP0000372_irregular_coat_pigmentation1.24055889
59MP0000569_abnormal_digit_pigmentation1.23348773
60MP0000613_abnormal_salivary_gland1.21916054
61MP0009379_abnormal_foot_pigmentation1.18919728
62MP0004742_abnormal_vestibular_system1.18524937
63MP0001835_abnormal_antigen_presentation1.18080978
64MP0002876_abnormal_thyroid_physiology1.16710592
65MP0003937_abnormal_limbs/digits/tail_de1.14755500
66MP0008932_abnormal_embryonic_tissue1.13894135
67MP0005551_abnormal_eye_electrophysiolog1.13582445
68MP0001119_abnormal_female_reproductive1.10108406
69MP0002234_abnormal_pharynx_morphology1.09433278
70MP0001929_abnormal_gametogenesis1.09308293
71MP0005310_abnormal_salivary_gland1.08470922
72MP0002148_abnormal_hypersensitivity_rea1.05576337
73MP0009764_decreased_sensitivity_to1.01462972
74MP0004215_abnormal_myocardial_fiber1.00409030
75MP0001346_abnormal_lacrimal_gland1.00141225
76MP0001486_abnormal_startle_reflex0.99875292
77MP0002009_preneoplasia0.99686506
78MP0006035_abnormal_mitochondrial_morpho0.99128828
79MP0000026_abnormal_inner_ear0.98698824
80MP0002751_abnormal_autonomic_nervous0.98179216
81MP0002177_abnormal_outer_ear0.97706541
82MP0003763_abnormal_thymus_physiology0.97089460
83MP0000653_abnormal_sex_gland0.97033413
84MP0004782_abnormal_surfactant_physiolog0.96173914
85MP0005387_immune_system_phenotype0.94957435
86MP0001790_abnormal_immune_system0.94957435
87MP0002098_abnormal_vibrissa_morphology0.94784059
88MP0003938_abnormal_ear_development0.94654281
89MP0005645_abnormal_hypothalamus_physiol0.94445903
90MP0005647_abnormal_sex_gland0.93926793
91MP0001186_pigmentation_phenotype0.93879445
92MP0003195_calcinosis0.93578259
93MP0003878_abnormal_ear_physiology0.92105347
94MP0005377_hearing/vestibular/ear_phenot0.92105347
95MP0004142_abnormal_muscle_tone0.91764737
96MP0001145_abnormal_male_reproductive0.91370373
97MP0000579_abnormal_nail_morphology0.89540440
98MP0003950_abnormal_plasma_membrane0.89275861
99MP0001800_abnormal_humoral_immune0.88937096
100MP0000490_abnormal_crypts_of0.88342475
101MP0008004_abnormal_stomach_pH0.87019150
102MP0003880_abnormal_central_pattern0.85820303
103MP0004808_abnormal_hematopoietic_stem0.84949817
104MP0002249_abnormal_larynx_morphology0.84285324
105MP0002723_abnormal_immune_serum0.84143496
106MP0001293_anophthalmia0.83933008
107MP0009785_altered_susceptibility_to0.83373869
108MP0006072_abnormal_retinal_apoptosis0.83160859
109MP0003121_genomic_imprinting0.82567031
110MP0003698_abnormal_male_reproductive0.82443233
111MP0005408_hypopigmentation0.82191660
112MP0010678_abnormal_skin_adnexa0.82008419
113MP0002419_abnormal_innate_immunity0.81710619
114MP0002452_abnormal_antigen_presenting0.81517629
115MP0003315_abnormal_perineum_morphology0.81122089
116MP0006276_abnormal_autonomic_nervous0.80849953
117MP0001984_abnormal_olfaction0.80531426
118MP0002067_abnormal_sensory_capabilities0.80474681
119MP0005395_other_phenotype0.79993609
120MP0001529_abnormal_vocalization0.79492640
121MP0002398_abnormal_bone_marrow0.79290666
122MP0000689_abnormal_spleen_morphology0.78849632
123MP0002735_abnormal_chemical_nociception0.78835652
124MP0003567_abnormal_fetal_cardiomyocyte0.78200856
125MP0001963_abnormal_hearing_physiology0.77628863
126MP0002166_altered_tumor_susceptibility0.77618187
127MP0005646_abnormal_pituitary_gland0.76241997
128MP0005389_reproductive_system_phenotype0.76004639
129MP0005000_abnormal_immune_tolerance0.75414127
130MP0002332_abnormal_exercise_endurance0.75357365
131MP0000049_abnormal_middle_ear0.74716141
132MP0003183_abnormal_peptide_metabolism0.74232244
133MP0002138_abnormal_hepatobiliary_system0.73557688
134MP0001919_abnormal_reproductive_system0.72682942
135MP0002168_other_aberrant_phenotype0.72554240
136MP0000427_abnormal_hair_cycle0.72288402
137MP0005025_abnormal_response_to0.72165248
138MP0001485_abnormal_pinna_reflex0.71771905
139MP0002075_abnormal_coat/hair_pigmentati0.71277898
140MP0001286_abnormal_eye_development0.71113471
141MP0000230_abnormal_systemic_arterial0.70554146
142MP0002160_abnormal_reproductive_system0.70481387
143MP0005253_abnormal_eye_physiology0.69761326
144MP0001191_abnormal_skin_condition0.69702007
145MP0000647_abnormal_sebaceous_gland0.69492658
146MP0004811_abnormal_neuron_physiology0.69098027
147MP0002420_abnormal_adaptive_immunity0.67381567
148MP0006082_CNS_inflammation0.67126609
149MP0005266_abnormal_metabolism0.66014013
150MP0004145_abnormal_muscle_electrophysio0.65447190
151MP0001819_abnormal_immune_cell0.65180546
152MP0008775_abnormal_heart_ventricle0.64793750
153MP0000716_abnormal_immune_system0.64277520
154MP0002722_abnormal_immune_system0.63418681
155MP0003436_decreased_susceptibility_to0.62779939
156MP0001784_abnormal_fluid_regulation0.61171411
157MP0003122_maternal_imprinting0.60421667
158MP0001177_atelectasis0.59323440
159MP0004924_abnormal_behavior0.59291980
160MP0005386_behavior/neurological_phenoty0.59291980
161MP0005195_abnormal_posterior_eye0.56204556

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.42144745
2Chromsome breakage (HP:0040012)6.01448315
3Abnormal hair whorl (HP:0010721)5.62212028
4Rectal fistula (HP:0100590)5.18111885
5Rectovaginal fistula (HP:0000143)5.18111885
6Intestinal fistula (HP:0100819)4.51853547
7Vaginal fistula (HP:0004320)4.20420747
8Hypochromic microcytic anemia (HP:0004840)3.96485194
9Prostate neoplasm (HP:0100787)3.94156989
10Hyperlipoproteinemia (HP:0010980)3.80202299
11Abnormality of the renal collecting system (HP:0004742)3.68587801
12Duplicated collecting system (HP:0000081)3.65999090
13Skull defect (HP:0001362)3.59040694
14Acute lymphatic leukemia (HP:0006721)3.38885518
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.38719611
16Portal hypertension (HP:0001409)3.28623368
17Meckel diverticulum (HP:0002245)3.28104841
18Abnormality of the preputium (HP:0100587)3.25723081
19Septate vagina (HP:0001153)3.24665392
20Hypoproteinemia (HP:0003075)3.23422715
21Horizontal nystagmus (HP:0000666)3.21919299
22Aplasia/Hypoplasia of the uvula (HP:0010293)3.15839363
23Abnormality of the ileum (HP:0001549)3.10601095
24Abnormality of chromosome stability (HP:0003220)3.05479983
25Intestinal atresia (HP:0011100)3.03329874
26Abnormality of the hepatic vasculature (HP:0006707)2.94911298
27Generalized hypopigmentation of hair (HP:0011358)2.93231845
28Papillary thyroid carcinoma (HP:0002895)2.88082393
29Abnormality of B cell number (HP:0010975)2.86638316
30Exocrine pancreatic insufficiency (HP:0001738)2.83667318
31Clubbing of toes (HP:0100760)2.82431039
32B lymphocytopenia (HP:0010976)2.77818630
33T lymphocytopenia (HP:0005403)2.77114100
34Abnormality of the prostate (HP:0008775)2.77067578
35Volvulus (HP:0002580)2.74325353
36Tubulointerstitial nephritis (HP:0001970)2.73933566
37Progressive cerebellar ataxia (HP:0002073)2.71423472
38Molar tooth sign on MRI (HP:0002419)2.71103168
39Abnormality of midbrain morphology (HP:0002418)2.71103168
40Osteomalacia (HP:0002749)2.69819420
41Medial flaring of the eyebrow (HP:0010747)2.64408038
42Ectopic kidney (HP:0000086)2.62751625
43Abnormality of T cell number (HP:0011839)2.61422550
44Clitoromegaly (HP:0000057)2.59635933
45Genital tract atresia (HP:0001827)2.57343413
46Autoimmune hemolytic anemia (HP:0001890)2.56260087
47Abnormality of DNA repair (HP:0003254)2.54467689
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.52917148
49Absent/shortened dynein arms (HP:0200106)2.52917148
50Anteriorly placed anus (HP:0001545)2.48030460
51Thyroiditis (HP:0100646)2.47756037
52Abnormal ciliary motility (HP:0012262)2.45770877
53Medulloblastoma (HP:0002885)2.44172717
54Vaginal atresia (HP:0000148)2.44087546
55Septo-optic dysplasia (HP:0100842)2.43493550
56Congenital hepatic fibrosis (HP:0002612)2.42618430
57Upper limb muscle weakness (HP:0003484)2.40286118
58Lip pit (HP:0100267)2.40211270
59Type 2 muscle fiber atrophy (HP:0003554)2.39456895
60Adactyly (HP:0009776)2.39087011
61Stomach cancer (HP:0012126)2.36259425
62Abnormal respiratory motile cilium physiology (HP:0012261)2.35886698
63Nephroblastoma (Wilms tumor) (HP:0002667)2.31626182
64Abnormality of incisor morphology (HP:0011063)2.29255036
65Pancreatic fibrosis (HP:0100732)2.29092990
66Birth length less than 3rd percentile (HP:0003561)2.28716616
67Median cleft lip (HP:0000161)2.26791914
68Small intestinal stenosis (HP:0012848)2.24051577
69Duodenal stenosis (HP:0100867)2.24051577
70Duplication of thumb phalanx (HP:0009942)2.24011664
71Congenital primary aphakia (HP:0007707)2.23183436
72Renal cortical cysts (HP:0000803)2.21365581
73True hermaphroditism (HP:0010459)2.17906527
74Gait imbalance (HP:0002141)2.17079275
75Drooling (HP:0002307)2.16062665
76Absent radius (HP:0003974)2.13651921
77Embryonal renal neoplasm (HP:0011794)2.13262518
78Nephrogenic diabetes insipidus (HP:0009806)2.11295225
79Pancreatic cysts (HP:0001737)2.10490667
80White forelock (HP:0002211)2.08496235
81Excessive salivation (HP:0003781)2.07817716
82Triphalangeal thumb (HP:0001199)2.07763660
83Patchy hypopigmentation of hair (HP:0011365)2.06691911
84Hypergonadotropic hypogonadism (HP:0000815)2.06045459
85Stomatitis (HP:0010280)2.05520528
86Abnormal respiratory motile cilium morphology (HP:0005938)2.05372111
87Abnormal respiratory epithelium morphology (HP:0012253)2.05372111
88Type I transferrin isoform profile (HP:0003642)2.02089621
89Bone marrow hypocellularity (HP:0005528)2.02026039
90Thyroid carcinoma (HP:0002890)2.00827224
91Congenital sensorineural hearing impairment (HP:0008527)2.00613229
92Widely spaced teeth (HP:0000687)2.00450101
93Preaxial hand polydactyly (HP:0001177)1.98274506
94Truncal obesity (HP:0001956)1.98245943
95Absent forearm bone (HP:0003953)1.98137069
96Aplasia involving forearm bones (HP:0009822)1.98137069
97Aplasia cutis congenita (HP:0001057)1.98003904
98Hypophosphatemic rickets (HP:0004912)1.97196865
99Reticulocytopenia (HP:0001896)1.96986710
100Abnormality of the nasolacrimal system (HP:0000614)1.96923721
101Abnormality of the carotid arteries (HP:0005344)1.96819606
102Gaze-evoked nystagmus (HP:0000640)1.96540835
103Short thumb (HP:0009778)1.96198759
104Azoospermia (HP:0000027)1.96093909
105Optic neuritis (HP:0100653)1.95601265
106Retrobulbar optic neuritis (HP:0100654)1.95601265
107Abnormal spermatogenesis (HP:0008669)1.95011417
108Microvesicular hepatic steatosis (HP:0001414)1.94931326
109Male pseudohermaphroditism (HP:0000037)1.93084997
110Failure to thrive in infancy (HP:0001531)1.92492092
111Abnormality of male internal genitalia (HP:0000022)1.91218577
112Postaxial foot polydactyly (HP:0001830)1.90834906
113Aplasia/Hypoplasia of the tongue (HP:0010295)1.90057609
114Low anterior hairline (HP:0000294)1.89741989
115Autoimmune thrombocytopenia (HP:0001973)1.88545562
116Glioma (HP:0009733)1.88130104
117Hypoplastic nipples (HP:0002557)1.87121276
118Chronic hepatic failure (HP:0100626)1.86941412
119Recurrent pneumonia (HP:0006532)1.86097870
120Submucous cleft hard palate (HP:0000176)1.85845026
121Adrenal hypoplasia (HP:0000835)1.85135966
122Hypoplasia of the fovea (HP:0007750)1.84501846
123Aplasia/Hypoplasia of the fovea (HP:0008060)1.84501846
124Generalized aminoaciduria (HP:0002909)1.84449274
125Aplasia/Hypoplasia of the earlobes (HP:0009906)1.83711848
126Abnormal drinking behavior (HP:0030082)1.83314691
127Polydipsia (HP:0001959)1.83314691
128Abnormality of the axillary hair (HP:0100134)1.83219909
129Abnormality of secondary sexual hair (HP:0009888)1.83219909
130Nasolacrimal duct obstruction (HP:0000579)1.83164099
131Chronic obstructive pulmonary disease (HP:0006510)1.82509909
132Obstructive lung disease (HP:0006536)1.82509909
133Absent speech (HP:0001344)1.82492701
134Chronic sinusitis (HP:0011109)1.82087226
135Delayed puberty (HP:0000823)1.82036609
136Ectopic anus (HP:0004397)1.81569794
137Oligohydramnios (HP:0001562)1.81507856
138Abnormality of the heme biosynthetic pathway (HP:0010472)1.81347919
139Muscle fiber atrophy (HP:0100295)1.79846676
140Abnormality of the renal medulla (HP:0100957)1.79780344
141Hyperglycinemia (HP:0002154)1.79457032
142Impulsivity (HP:0100710)1.79122354
143Renal Fanconi syndrome (HP:0001994)1.78611783
144Hypothermia (HP:0002045)1.78216412
145Poor coordination (HP:0002370)1.77939814
146Microcytic anemia (HP:0001935)1.77920223
147Fair hair (HP:0002286)1.77781802
148Congenital stationary night blindness (HP:0007642)1.77176430
149Myelodysplasia (HP:0002863)1.76682968
150Supernumerary spleens (HP:0009799)1.76444730
151Alveolar cell carcinoma (HP:0006519)1.75889766
152Reduced antithrombin III activity (HP:0001976)1.75685793
153Abnormality of the duodenum (HP:0002246)1.75483147
154Tented upper lip vermilion (HP:0010804)1.74691165
155Hyperventilation (HP:0002883)1.73369957
156Abnormality of the clitoris (HP:0000056)1.73341512
157Abnormality of the septum pellucidum (HP:0007375)1.72955674
158Severe combined immunodeficiency (HP:0004430)1.72616111
159Occipital encephalocele (HP:0002085)1.72287527
160Gingival bleeding (HP:0000225)1.71986258
161Chronic mucocutaneous candidiasis (HP:0002728)1.71888478
162Recurrent cutaneous fungal infections (HP:0011370)1.71888478
163Absent septum pellucidum (HP:0001331)1.71673076
164Abnormality of the nasal septum (HP:0000419)1.71659902
165Nephronophthisis (HP:0000090)1.71599100
166Rhabdomyosarcoma (HP:0002859)1.71492819
167Abnormality of the columella (HP:0009929)1.71296035
1682-3 toe syndactyly (HP:0004691)1.70481579
169Optic nerve hypoplasia (HP:0000609)1.70163924
170Capillary hemangiomas (HP:0005306)1.69769068
171Conical tooth (HP:0000698)1.69620677
172Encephalitis (HP:0002383)1.68223217
173Parakeratosis (HP:0001036)1.68078590
174Cutis marmorata (HP:0000965)1.67922787
175Absent hand (HP:0004050)1.67899030
176Abnormal delayed hypersensitivity skin test (HP:0002963)1.67419389
177Prolonged neonatal jaundice (HP:0006579)1.66878189
178Facial cleft (HP:0002006)1.66519709
179Febrile seizures (HP:0002373)1.66512770
180Decreased central vision (HP:0007663)1.66235724
181Attenuation of retinal blood vessels (HP:0007843)1.66185484

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.69489037
2STK163.10719524
3TNIK3.00095301
4ZAK2.97071127
5MKNK22.70410685
6IRAK32.68830481
7CASK2.53640190
8EIF2AK22.52594733
9SRPK12.40122125
10TXK2.24815299
11MAP3K142.23798800
12WNK32.10186384
13IRAK42.05844737
14NUAK12.02068019
15MAP3K41.99168307
16PLK41.95839916
17MKNK11.85518134
18TEC1.71993991
19NLK1.70986417
20GRK11.67620083
21FLT31.63650014
22CDK31.56026968
23PAK31.51360057
24BRD41.51103671
25PLK21.50540367
26BMPR1B1.47712880
27TRIM281.47114041
28EIF2AK31.46002775
29VRK11.42490306
30STK38L1.39929898
31AKT31.37986705
32NEK61.37356097
33ADRBK21.37233772
34FER1.31100113
35TTK1.30381352
36FGFR31.29795938
37INSRR1.28625119
38CSF1R1.24207709
39MUSK1.22297552
40MAP3K11.17836616
41YES11.17425400
42TLK11.16629866
43BMPR21.15993661
44PBK1.14484807
45CDK191.14388651
46MAP2K71.09969712
47CLK11.09676495
48CAMKK21.09180928
49DYRK31.07732425
50ERBB21.05957818
51TAOK11.05230064
52PKN11.02184596
53SYK1.00218626
54EIF2AK10.99069772
55IRAK10.98239895
56PLK10.97544767
57CHEK20.94671969
58PTK2B0.94043513
59PIK3CG0.93552811
60FGR0.93234205
61GRK70.91556553
62IKBKB0.89579612
63PINK10.89079474
64IRAK20.88926147
65LATS10.88381683
66WNK10.87034257
67STK40.86635460
68DYRK1B0.86347995
69ATR0.85316424
70BRSK20.83560604
71BLK0.81374470
72MAP3K50.80492688
73STK30.79180621
74HCK0.79155760
75ZAP700.78766997
76WEE10.78052814
77BCR0.77553998
78CDC70.77043444
79PLK30.75695401
80IKBKE0.75199574
81MAP3K20.75141860
82SGK20.72955495
83SIK30.71972826
84MST40.70724063
85NME20.69900642
86RIPK40.69838634
87TAOK30.69360353
88ERBB30.68506420
89BUB10.68434595
90EGFR0.67846828
91RPS6KA50.67652546
92CDK70.66426791
93GRK60.66165180
94AURKB0.65559719
95STK240.65264391
96CSNK1G20.63681034
97CDK90.61377801
98TIE10.59903807
99ACVR1B0.59499459
100CDK80.59478039
101MAPK130.59371830
102ATM0.59330291
103MAP2K40.59081528
104PRPF4B0.57937657
105KIT0.56936056
106KSR10.56597968
107CHUK0.55849466
108CSK0.55188594
109JAK20.54452536
110NEK90.54076446
111MAPK70.52385715
112CSNK1G10.52237576
113CDK120.52150315
114STK390.52083384
115CCNB10.51977238
116TYK20.50780476
117SGK4940.48763171
118SGK2230.48763171
119EPHA20.48256685
120DYRK20.47883461
121CHEK10.47503708
122LYN0.46848567
123DYRK1A0.46726990
124TRPM70.46559677
125MAPK150.46519671
126MARK30.46194047
127BTK0.44444277
128OXSR10.44433572
129GRK50.44390101
130CSNK1A1L0.44381375
131LCK0.42002317
132CAMK10.41908496
133MAP3K60.41903425
134PNCK0.41788157
135JAK30.41669487
136FES0.41506875
137PIM10.40191869
138TAOK20.37752512
139CSNK2A10.36065043
140PRKCE0.35620255
141EPHA30.35211498
142PIK3CA0.34436972
143PRKAA20.34269164
144FRK0.33595079
145OBSCN0.33502706

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.70871138
2Homologous recombination_Homo sapiens_hsa034403.15854297
3Dorso-ventral axis formation_Homo sapiens_hsa043202.63663715
4Basal transcription factors_Homo sapiens_hsa030222.59137602
5RNA polymerase_Homo sapiens_hsa030202.40252310
6Non-homologous end-joining_Homo sapiens_hsa034502.40000595
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.19761594
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15871585
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.11769793
10Mismatch repair_Homo sapiens_hsa034301.91613611
11Vitamin B6 metabolism_Homo sapiens_hsa007501.89784080
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.80215450
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77187478
14Sphingolipid metabolism_Homo sapiens_hsa006001.58369942
15Autoimmune thyroid disease_Homo sapiens_hsa053201.56003511
16Nucleotide excision repair_Homo sapiens_hsa034201.54946166
17Arachidonic acid metabolism_Homo sapiens_hsa005901.52788753
18Osteoclast differentiation_Homo sapiens_hsa043801.51884349
19Pyrimidine metabolism_Homo sapiens_hsa002401.51442378
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.51116301
21DNA replication_Homo sapiens_hsa030301.50645360
22Cell cycle_Homo sapiens_hsa041101.50405560
23Primary immunodeficiency_Homo sapiens_hsa053401.49480073
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46786427
25Graft-versus-host disease_Homo sapiens_hsa053321.46458659
26Legionellosis_Homo sapiens_hsa051341.46215201
27Allograft rejection_Homo sapiens_hsa053301.45155404
28Vitamin digestion and absorption_Homo sapiens_hsa049771.43877897
29RNA degradation_Homo sapiens_hsa030181.42482522
30Platelet activation_Homo sapiens_hsa046111.40568021
31Hematopoietic cell lineage_Homo sapiens_hsa046401.40409985
32Base excision repair_Homo sapiens_hsa034101.40294727
33Phototransduction_Homo sapiens_hsa047441.38255484
34Ether lipid metabolism_Homo sapiens_hsa005651.38084962
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.35180829
36Caffeine metabolism_Homo sapiens_hsa002321.33270216
37Prolactin signaling pathway_Homo sapiens_hsa049171.33176928
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.32205518
39Olfactory transduction_Homo sapiens_hsa047401.30521971
40Linoleic acid metabolism_Homo sapiens_hsa005911.30362417
41p53 signaling pathway_Homo sapiens_hsa041151.28531040
42Nitrogen metabolism_Homo sapiens_hsa009101.26053586
43Viral carcinogenesis_Homo sapiens_hsa052031.25629718
44FoxO signaling pathway_Homo sapiens_hsa040681.25245644
45Purine metabolism_Homo sapiens_hsa002301.23211410
46Long-term depression_Homo sapiens_hsa047301.22154620
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20316809
48Herpes simplex infection_Homo sapiens_hsa051681.19926561
49Spliceosome_Homo sapiens_hsa030401.18237015
50Hepatitis B_Homo sapiens_hsa051611.12531299
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12422687
52Measles_Homo sapiens_hsa051621.12417284
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11788009
54Chemokine signaling pathway_Homo sapiens_hsa040621.10614659
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09608916
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08635935
57Tuberculosis_Homo sapiens_hsa051521.08631845
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07806153
59B cell receptor signaling pathway_Homo sapiens_hsa046621.07675645
60Protein export_Homo sapiens_hsa030601.07001307
61Ribosome_Homo sapiens_hsa030101.05950647
62Asthma_Homo sapiens_hsa053101.04760798
63RNA transport_Homo sapiens_hsa030131.04261554
64Regulation of autophagy_Homo sapiens_hsa041401.01389132
65Proteasome_Homo sapiens_hsa030500.97527143
66mRNA surveillance pathway_Homo sapiens_hsa030150.95207579
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94418882
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93226751
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93142083
70Rheumatoid arthritis_Homo sapiens_hsa053230.90590306
71One carbon pool by folate_Homo sapiens_hsa006700.90516711
72Systemic lupus erythematosus_Homo sapiens_hsa053220.88278580
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87769540
74mTOR signaling pathway_Homo sapiens_hsa041500.87714648
75Alcoholism_Homo sapiens_hsa050340.87581971
76Non-small cell lung cancer_Homo sapiens_hsa052230.87504638
77Oocyte meiosis_Homo sapiens_hsa041140.87261514
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.86286168
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85148210
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84983533
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84446356
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.83411108
83Pancreatic cancer_Homo sapiens_hsa052120.83357782
84Steroid biosynthesis_Homo sapiens_hsa001000.79311599
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75259613
86Circadian rhythm_Homo sapiens_hsa047100.74996536
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74905055
88Malaria_Homo sapiens_hsa051440.72044785
89Other glycan degradation_Homo sapiens_hsa005110.71181922
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69163402
91Staphylococcus aureus infection_Homo sapiens_hsa051500.68294146
92Fatty acid biosynthesis_Homo sapiens_hsa000610.68249776
93Epstein-Barr virus infection_Homo sapiens_hsa051690.68010233
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67739822
95Nicotine addiction_Homo sapiens_hsa050330.66213105
96Influenza A_Homo sapiens_hsa051640.65770659
97Ovarian steroidogenesis_Homo sapiens_hsa049130.63402787
98Retinol metabolism_Homo sapiens_hsa008300.62255052
99Propanoate metabolism_Homo sapiens_hsa006400.61830134
100Gap junction_Homo sapiens_hsa045400.60036339
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59750003
102Renal cell carcinoma_Homo sapiens_hsa052110.59148036
103Histidine metabolism_Homo sapiens_hsa003400.58818591
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58068448
105ErbB signaling pathway_Homo sapiens_hsa040120.57388897
106Butanoate metabolism_Homo sapiens_hsa006500.57218847
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57195294
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55148711
109Phagosome_Homo sapiens_hsa041450.55133798
110Melanoma_Homo sapiens_hsa052180.55055514
111Ras signaling pathway_Homo sapiens_hsa040140.53395672
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.52347350
113Pertussis_Homo sapiens_hsa051330.52076888
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51248797
115TNF signaling pathway_Homo sapiens_hsa046680.50996393
116Basal cell carcinoma_Homo sapiens_hsa052170.49772823
117MicroRNAs in cancer_Homo sapiens_hsa052060.47315740
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46964109
119Chronic myeloid leukemia_Homo sapiens_hsa052200.46471263
120Morphine addiction_Homo sapiens_hsa050320.46398058
121Endometrial cancer_Homo sapiens_hsa052130.46070224
122Toxoplasmosis_Homo sapiens_hsa051450.45628648
123Renin secretion_Homo sapiens_hsa049240.45225421
124Acute myeloid leukemia_Homo sapiens_hsa052210.43555309
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43070049
126Choline metabolism in cancer_Homo sapiens_hsa052310.43049776
127Lysine degradation_Homo sapiens_hsa003100.42371706
128Taste transduction_Homo sapiens_hsa047420.42054512
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41109664
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41048738
131Prostate cancer_Homo sapiens_hsa052150.40492296
132TGF-beta signaling pathway_Homo sapiens_hsa043500.40379445
133ABC transporters_Homo sapiens_hsa020100.40306924
134Inositol phosphate metabolism_Homo sapiens_hsa005620.39165884
135Small cell lung cancer_Homo sapiens_hsa052220.38731806
136African trypanosomiasis_Homo sapiens_hsa051430.36957564
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35469295
138beta-Alanine metabolism_Homo sapiens_hsa004100.35235923
139Hepatitis C_Homo sapiens_hsa051600.35109739
140Antigen processing and presentation_Homo sapiens_hsa046120.33995200
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.31937397
142Mineral absorption_Homo sapiens_hsa049780.30441094
143Folate biosynthesis_Homo sapiens_hsa007900.29909826
144Leishmaniasis_Homo sapiens_hsa051400.29816193
145T cell receptor signaling pathway_Homo sapiens_hsa046600.29442789
146Metabolic pathways_Homo sapiens_hsa011000.29342927
147Type I diabetes mellitus_Homo sapiens_hsa049400.29320741
148Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29119835
149Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28558567
150Pathways in cancer_Homo sapiens_hsa052000.28482279

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