SUSD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte development (GO:0002063)9.69615618
2cartilage development involved in endochondral bone morphogenesis (GO:0060351)9.25983470
3gonadal mesoderm development (GO:0007506)8.46534920
4cartilage condensation (GO:0001502)8.05110025
5cell aggregation (GO:0098743)8.05110025
6keratan sulfate catabolic process (GO:0042340)6.84891822
7collagen fibril organization (GO:0030199)6.60845150
8chondroitin sulfate biosynthetic process (GO:0030206)5.98384656
9positive regulation of extracellular matrix organization (GO:1903055)5.81839495
10limb bud formation (GO:0060174)5.37217441
11notochord development (GO:0030903)5.27693648
12replacement ossification (GO:0036075)5.17319504
13endochondral ossification (GO:0001958)5.17319504
14cartilage development (GO:0051216)4.96942064
15dermatan sulfate biosynthetic process (GO:0030208)4.90623777
16negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.81029216
17dermatan sulfate metabolic process (GO:0030205)4.75642365
18collagen catabolic process (GO:0030574)4.64050420
19embryonic skeletal joint morphogenesis (GO:0060272)4.53772302
20collagen metabolic process (GO:0032963)4.44900574
21regulation of plasminogen activation (GO:0010755)4.44842724
22chondrocyte differentiation (GO:0002062)4.39720988
23proteoglycan metabolic process (GO:0006029)4.39321276
24neuron cell-cell adhesion (GO:0007158)4.34468051
25chondroitin sulfate catabolic process (GO:0030207)4.30290524
26multicellular organismal catabolic process (GO:0044243)4.23989351
27multicellular organismal macromolecule metabolic process (GO:0044259)4.19772676
28chondrocyte proliferation (GO:0035988)4.19031723
29positive regulation of chondrocyte differentiation (GO:0032332)4.11428285
30multicellular organismal metabolic process (GO:0044236)3.94515774
31regulation of extracellular matrix disassembly (GO:0010715)3.80947314
32endocardial cushion morphogenesis (GO:0003203)3.77734495
33iron ion import (GO:0097286)3.75386347
34positive regulation of cartilage development (GO:0061036)3.73927686
35skeletal system development (GO:0001501)3.70121282
36hypotonic response (GO:0006971)3.69333945
37chondroitin sulfate metabolic process (GO:0030204)3.69204545
38response to BMP (GO:0071772)3.68573441
39cellular response to BMP stimulus (GO:0071773)3.68573441
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.62778900
41extracellular matrix disassembly (GO:0022617)3.59138239
42protein heterotrimerization (GO:0070208)3.58133887
43oligosaccharide catabolic process (GO:0009313)3.55594612
44synaptic vesicle docking involved in exocytosis (GO:0016081)3.52703115
45somite development (GO:0061053)3.49259742
46sphingomyelin metabolic process (GO:0006684)3.48675915
47keratan sulfate biosynthetic process (GO:0018146)3.46173954
48presynaptic membrane assembly (GO:0097105)3.43372231
49endothelial cell morphogenesis (GO:0001886)3.40481237
50regulation of extracellular matrix organization (GO:1903053)3.39924459
51glycosaminoglycan biosynthetic process (GO:0006024)3.38054323
52tooth mineralization (GO:0034505)3.34709265
53aminoglycan biosynthetic process (GO:0006023)3.33966560
54positive regulation of male gonad development (GO:2000020)3.30586501
55response to gravity (GO:0009629)3.22158148
56embryonic viscerocranium morphogenesis (GO:0048703)3.19519502
57appendage development (GO:0048736)3.18999037
58limb development (GO:0060173)3.18999037
59postsynaptic membrane organization (GO:0001941)3.17588507
60extracellular matrix organization (GO:0030198)3.17491101
61positive regulation of axon extension (GO:0045773)3.16821420
62extracellular structure organization (GO:0043062)3.16441842
63glycosphingolipid catabolic process (GO:0046479)3.16348022
64regulation of chondrocyte differentiation (GO:0032330)3.13294452
65skin morphogenesis (GO:0043589)3.11982795
66sulfur compound catabolic process (GO:0044273)3.11056771
67bone trabecula formation (GO:0060346)3.10611943
68locomotory exploration behavior (GO:0035641)3.09578223
69glycoprotein metabolic process (GO:0009100)3.05682136
70regulation of male gonad development (GO:2000018)3.04264616
71cGMP-mediated signaling (GO:0019934)3.03493873
72ossification (GO:0001503)3.00790235
73regulation of cartilage development (GO:0061035)3.00258777
74positive regulation of neurological system process (GO:0031646)2.99010776
75glial cell migration (GO:0008347)2.97762506
76short-term memory (GO:0007614)2.97286455
77negative regulation of cartilage development (GO:0061037)2.96781895
78endodermal cell differentiation (GO:0035987)2.96445746
79glycosaminoglycan catabolic process (GO:0006027)2.93008301
80negative regulation of gluconeogenesis (GO:0045721)2.92063062
81negative regulation of homotypic cell-cell adhesion (GO:0034111)2.91506825
82positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.90917876
83proteoglycan biosynthetic process (GO:0030166)2.88955096
84detection of mechanical stimulus involved in sensory perception (GO:0050974)2.88092083
85mesenchyme morphogenesis (GO:0072132)2.86096138
86lymphangiogenesis (GO:0001946)2.85655849
87connective tissue development (GO:0061448)2.85152473
88regulation of short-term neuronal synaptic plasticity (GO:0048172)2.84967137
89protein retention in ER lumen (GO:0006621)2.83026603
90detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.82131774
91glycolipid catabolic process (GO:0019377)2.79572062
92myelin assembly (GO:0032288)2.78703238
93mesenchymal cell development (GO:0014031)2.77804521
94positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.76396865
95keratan sulfate metabolic process (GO:0042339)2.74452824
96regulation of axon regeneration (GO:0048679)2.74147276
97regulation of neuron projection regeneration (GO:0070570)2.74147276
98nucleotide-sugar biosynthetic process (GO:0009226)2.73804199
99peptidyl-proline hydroxylation (GO:0019511)2.73246621
100regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.73061060
101DNA strand renaturation (GO:0000733)2.72754670
102aminoglycan catabolic process (GO:0006026)2.72609995
103regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.69013590
104cell proliferation involved in kidney development (GO:0072111)2.68932106
105glycoprotein catabolic process (GO:0006516)2.68171085
106bone development (GO:0060348)2.67540747
107cullin deneddylation (GO:0010388)2.53996800
108protein deneddylation (GO:0000338)2.48890920
109DNA replication checkpoint (GO:0000076)2.46205836
110meiotic chromosome segregation (GO:0045132)2.43330274
111positive regulation of osteoblast proliferation (GO:0033690)2.37594809
112cellular potassium ion homeostasis (GO:0030007)2.33444135
113neuronal action potential propagation (GO:0019227)2.31510235
114negative regulation of cell aging (GO:0090344)2.30788015
115maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.30271014
116protein localization to synapse (GO:0035418)2.29066742
117behavioral response to nicotine (GO:0035095)2.28563057
118synaptic vesicle maturation (GO:0016188)2.28411675
119glutamate secretion (GO:0014047)2.27697852
120cell fate commitment involved in formation of primary germ layer (GO:0060795)2.26002770
121regulation of synapse structural plasticity (GO:0051823)2.22813736
122chromatin remodeling at centromere (GO:0031055)2.21817732
123CENP-A containing nucleosome assembly (GO:0034080)2.20159310
124positive regulation of cell size (GO:0045793)2.18036909
125protein K6-linked ubiquitination (GO:0085020)2.16118336
126mitotic sister chromatid segregation (GO:0000070)2.15425975
127cellular protein complex localization (GO:0034629)2.15198630
128generation of neurons (GO:0048699)2.14489130
129mitotic cytokinesis (GO:0000281)2.13830650
130positive regulation of cell cycle G2/M phase transition (GO:1902751)2.12981309
131positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.12981309
132cytoskeleton-dependent cytokinesis (GO:0061640)2.12122967
133ventricular cardiac muscle cell development (GO:0055015)2.11411572
134behavioral response to cocaine (GO:0048148)2.11285479
135heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.08890195
136paraxial mesoderm development (GO:0048339)2.04899563
137protein complex localization (GO:0031503)2.02349485
138kidney mesenchyme development (GO:0072074)2.01816501
139urinary tract smooth muscle contraction (GO:0014848)2.01557307
140protein maturation by protein folding (GO:0022417)2.00530122
141regulation of respiratory gaseous exchange by neurological system process (GO:0002087)1.99857026
142regulation of nuclear cell cycle DNA replication (GO:0033262)1.99076277
143histone exchange (GO:0043486)1.98646676
144regulation of respiratory system process (GO:0044065)1.98447789
145negative regulation of nitric-oxide synthase activity (GO:0051001)1.96964201
146nuclear pore complex assembly (GO:0051292)1.96403538
147hippo signaling (GO:0035329)1.95457448
148regulation of cell aging (GO:0090342)1.95380762
149sister chromatid segregation (GO:0000819)1.95089988
150mitotic metaphase plate congression (GO:0007080)1.94528325
151pseudouridine synthesis (GO:0001522)1.94342896
152inner ear receptor cell development (GO:0060119)1.94284346
153ventricular septum development (GO:0003281)1.93941456
154DNA unwinding involved in DNA replication (GO:0006268)1.93291074
155cell adhesion mediated by integrin (GO:0033627)1.92908894
156mitotic spindle organization (GO:0007052)1.92617109
157maturation of 5.8S rRNA (GO:0000460)1.92299493
158protein heterotetramerization (GO:0051290)1.91630873
159L-serine metabolic process (GO:0006563)1.90765912
160neuromuscular synaptic transmission (GO:0007274)1.90645282
161substrate adhesion-dependent cell spreading (GO:0034446)1.89809462
162nuclear pore organization (GO:0006999)1.88762202
163L-methionine biosynthetic process from methylthioadenosine (GO:0019509)1.88002212
164protein localization to kinetochore (GO:0034501)1.86480243
165regulation of meiosis (GO:0040020)1.85037163
166retina vasculature morphogenesis in camera-type eye (GO:0061299)1.84876646
167UDP-N-acetylglucosamine metabolic process (GO:0006047)1.84863073
168positive regulation of mitochondrial calcium ion concentration (GO:0051561)1.84508940
169membrane assembly (GO:0071709)1.81255001
170neural crest cell development (GO:0014032)1.80978764
171plasma membrane repair (GO:0001778)1.80854527
172nephron tubule formation (GO:0072079)1.80109069
173sodium ion export (GO:0071436)1.79480435
174gamma-aminobutyric acid transport (GO:0015812)1.77760578
175regulation of mitotic spindle organization (GO:0060236)1.77347600
176mitotic cell cycle arrest (GO:0071850)1.76945731
177protein localization to chromosome, centromeric region (GO:0071459)1.76413947
178outer ear morphogenesis (GO:0042473)1.76142593
179spindle assembly involved in mitosis (GO:0090307)1.75342067
180regulation of glomerular filtration (GO:0003093)1.75139425
181regulation of centriole replication (GO:0046599)1.74521637
182peristalsis (GO:0030432)1.74368959
183metaphase plate congression (GO:0051310)1.74355031
184embryonic heart tube development (GO:0035050)1.74237978
185exploration behavior (GO:0035640)1.73548701

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1AR_21572438_ChIP-Seq_LNCaP_Human4.47275740
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.42943614
3E2F7_22180533_ChIP-Seq_HELA_Human3.99953503
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.85391201
5GBX2_23144817_ChIP-Seq_PC3_Human2.77699988
6EZH2_22144423_ChIP-Seq_EOC_Human2.73194384
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.72155664
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.64742311
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.63988845
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.59877355
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.52431493
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.50796210
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.50443854
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.41991517
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41545984
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41545984
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39654179
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37915306
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28220085
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.21432828
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16911927
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.87955941
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.86644194
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.84538920
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.83090214
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82635548
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.79038608
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76836420
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72337435
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.71992734
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71505023
32* CJUN_26792858_Chip-Seq_BT549_Human1.68807579
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.67253211
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62249995
35WT1_19549856_ChIP-ChIP_CCG9911_Human1.61941924
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59664290
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.58910779
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.57586735
39EWS_26573619_Chip-Seq_HEK293_Human1.56732420
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55976034
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.55822957
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54837674
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.52803655
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50678078
45AR_21909140_ChIP-Seq_LNCAP_Human1.50370793
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.49604099
47* EZH2_27294783_Chip-Seq_ESCs_Mouse1.49342659
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.47117469
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.45393763
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44971433
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44622792
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44435691
53ETS1_20019798_ChIP-Seq_JURKAT_Human1.44178512
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42641742
55CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.42280074
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40976320
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37195582
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37179970
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36746218
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.36219517
61SMAD4_21799915_ChIP-Seq_A2780_Human1.34967017
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34391790
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32102974
64CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29607614
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27120834
66XRN2_22483619_ChIP-Seq_HELA_Human1.26320554
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.25461258
68TP53_18474530_ChIP-ChIP_U2OS_Human1.25073588
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24501993
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24501993
71ELK1_19687146_ChIP-ChIP_HELA_Human1.24349404
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23900592
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22824154
74RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22194578
75ZNF274_21170338_ChIP-Seq_K562_Hela1.21867486
76SOX9_26525672_Chip-Seq_HEART_Mouse1.21030503
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.20637452
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19853648
79TAF15_26573619_Chip-Seq_HEK293_Human1.19378149
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.19124544
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18856262
82P300_19829295_ChIP-Seq_ESCs_Human1.16627648
83TP53_20018659_ChIP-ChIP_R1E_Mouse1.16411570
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16180502
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16180502
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15619594
87TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15498181
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13725618
89ER_23166858_ChIP-Seq_MCF-7_Human1.13656191
90BRD4_25478319_ChIP-Seq_HGPS_Human1.13473105
91FLI1_27457419_Chip-Seq_LIVER_Mouse1.13062904
92TP63_17297297_ChIP-ChIP_HaCaT_Human1.12843478
93VDR_22108803_ChIP-Seq_LS180_Human1.11651951
94POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10990178
95* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10971854
96MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.10752556
97MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10349005
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.09705430
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09454008
100* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09420894
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09292582
102DROSHA_22980978_ChIP-Seq_HELA_Human1.08930389
103SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08347691
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05685496
105SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05669926
106* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04217166
107TTF2_22483619_ChIP-Seq_HELA_Human1.03892190
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03802601
109MYC_18940864_ChIP-ChIP_HL60_Human1.03765801
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03090071
111VDR_24787735_ChIP-Seq_THP-1_Human1.03047570
112DCP1A_22483619_ChIP-Seq_HELA_Human1.02899777
113RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02135326
114SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02114760
115TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.01596028
116ARNT_22903824_ChIP-Seq_MCF-7_Human1.01534456
117AR_25329375_ChIP-Seq_VCAP_Human1.01153553
118EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00854165
119REST_21632747_ChIP-Seq_MESCs_Mouse1.00169210
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.00142946
121EZH2_27294783_Chip-Seq_NPCs_Mouse0.99898348
122HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99839183
123BCAT_22108803_ChIP-Seq_LS180_Human0.97797256
124GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97579778
125TP53_23651856_ChIP-Seq_MEFs_Mouse0.96895408
126STAT3_23295773_ChIP-Seq_U87_Human0.96800590
127JUN_21703547_ChIP-Seq_K562_Human0.96613667
128RING1B_27294783_Chip-Seq_NPCs_Mouse0.96359268
129NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96158992
130TP53_16413492_ChIP-PET_HCT116_Human0.95231046
131WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94822350
132BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94616926
133JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93839787
134FUS_26573619_Chip-Seq_HEK293_Human0.93750824
135NFE2_27457419_Chip-Seq_LIVER_Mouse0.93608467
136PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93495583
137MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92816168
138CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92267145
139EST1_17652178_ChIP-ChIP_JURKAT_Human0.92259646
140WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92100055
141FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91328249
142REST_18959480_ChIP-ChIP_MESCs_Mouse0.90520000
143YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90152871
144IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90145520
145POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89996914
146AHR_22903824_ChIP-Seq_MCF-7_Human0.89717020
147RUNX2_22187159_ChIP-Seq_PCA_Human0.89691434
148YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89511621
149POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88422137
150E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88387841
151E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87968844
152TBX3_20139965_ChIP-Seq_MESCs_Mouse0.85231877
153TBX3_20139965_ChIP-Seq_ESCs_Mouse0.84839380
154MYC_18358816_ChIP-ChIP_MESCs_Mouse0.84769224
155GABP_19822575_ChIP-Seq_HepG2_Human0.84412546
156NELFA_20434984_ChIP-Seq_ESCs_Mouse0.84212529
157EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82965960
158LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81438150
159TET1_21490601_ChIP-Seq_MESCs_Mouse0.80386920
160TBX5_21415370_ChIP-Seq_HL-1_Mouse0.79836118
161POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.79742800
162CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.79231679
163E2F1_21310950_ChIP-Seq_MCF-7_Human0.79052199
164SOX2_16153702_ChIP-ChIP_HESCs_Human0.77957444

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology5.08777114
2MP0004134_abnormal_chest_morphology5.06572324
3MP0002282_abnormal_trachea_morphology4.54368660
4MP0009250_abnormal_appendicular_skeleto4.03719254
5MP0002933_joint_inflammation3.60962148
6MP0000163_abnormal_cartilage_morphology3.42722076
7MP0008438_abnormal_cutaneous_collagen3.36602636
8MP0003646_muscle_fatigue3.31151338
9MP0005171_absent_coat_pigmentation3.08691763
10MP0002115_abnormal_skeleton_extremities2.82505835
11MP0001299_abnormal_eye_distance/2.72293161
12MP0003136_yellow_coat_color2.69938122
13MP0009384_cardiac_valve_regurgitation2.66733827
14MP0001542_abnormal_bone_strength2.48184030
15MP0002896_abnormal_bone_mineralization2.44099907
16MP0004272_abnormal_basement_membrane2.42000274
17MP0003950_abnormal_plasma_membrane2.41970744
18MP0009780_abnormal_chondrocyte_physiolo2.39187295
19MP0003279_aneurysm2.35219265
20MP0000751_myopathy2.30466945
21MP0002113_abnormal_skeleton_development2.29511030
22MP0005508_abnormal_skeleton_morphology2.26942211
23MP0000762_abnormal_tongue_morphology2.21982825
24MP0002089_abnormal_postnatal_growth/wei2.19759500
25MP0002108_abnormal_muscle_morphology2.18226722
26MP0003283_abnormal_digestive_organ2.10717410
27MP0010368_abnormal_lymphatic_system2.02794849
28MP0002109_abnormal_limb_morphology1.97393713
29MP0001270_distended_abdomen1.95944575
30MP0002102_abnormal_ear_morphology1.83564305
31MP0001958_emphysema1.82581763
32MP0005390_skeleton_phenotype1.80384371
33MP0004859_abnormal_synaptic_plasticity1.75472449
34MP0005623_abnormal_meninges_morphology1.71048728
35MP0004858_abnormal_nervous_system1.69362963
36MP0000049_abnormal_middle_ear1.67804879
37MP0002233_abnormal_nose_morphology1.66916330
38MP0005275_abnormal_skin_tensile1.65483146
39MP0002116_abnormal_craniofacial_bone1.62385849
40MP0002877_abnormal_melanocyte_morpholog1.55239322
41MP0002160_abnormal_reproductive_system1.50989115
42MP0001533_abnormal_skeleton_physiology1.50679905
43MP0003755_abnormal_palate_morphology1.47070107
44MP0003795_abnormal_bone_structure1.45459400
45MP0005174_abnormal_tail_pigmentation1.44176965
46MP0009046_muscle_twitch1.43221707
47MP0003941_abnormal_skin_development1.43043911
48MP0008007_abnormal_cellular_replicative1.42996464
49MP0000432_abnormal_head_morphology1.42456262
50MP0000462_abnormal_digestive_system1.40652231
51MP0003111_abnormal_nucleus_morphology1.37861475
52MP0010094_abnormal_chromosome_stability1.35938423
53MP0002249_abnormal_larynx_morphology1.34676606
54MP0001188_hyperpigmentation1.32486624
55MP0003091_abnormal_cell_migration1.31962599
56MP0005187_abnormal_penis_morphology1.30367860
57MP0003566_abnormal_cell_adhesion1.28780794
58MP0009745_abnormal_behavioral_response1.28595096
59MP0002998_abnormal_bone_remodeling1.25568246
60MP0003385_abnormal_body_wall1.23797128
61MP0005423_abnormal_somatic_nervous1.16427354
62MP0002064_seizures1.16373472
63MP0001661_extended_life_span1.14488611
64MP0002272_abnormal_nervous_system1.14227785
65MP0000767_abnormal_smooth_muscle1.13978988
66MP0003937_abnormal_limbs/digits/tail_de1.13726615
67MP0001879_abnormal_lymphatic_vessel1.11987830
68MP0002114_abnormal_axial_skeleton1.10968901
69MP0004215_abnormal_myocardial_fiber1.10709421
70MP0000013_abnormal_adipose_tissue1.10074644
71MP0002932_abnormal_joint_morphology1.09813985
72MP0001486_abnormal_startle_reflex1.09187439
73MP0001346_abnormal_lacrimal_gland1.08812207
74MP0003942_abnormal_urinary_system1.08502265
75MP0005164_abnormal_response_to1.08393353
76MP0003935_abnormal_craniofacial_develop1.08276108
77MP0002572_abnormal_emotion/affect_behav1.07441814
78MP0004885_abnormal_endolymph1.05288701
79MP0003122_maternal_imprinting1.05229207
80MP0002909_abnormal_adrenal_gland1.04735093
81MP0003123_paternal_imprinting1.03255798
82MP0000428_abnormal_craniofacial_morphol1.02108141
83MP0005551_abnormal_eye_electrophysiolog1.02002233
84MP0010352_gastrointestinal_tract_polyps1.00841276
85MP0002063_abnormal_learning/memory/cond0.98220261
86MP0002734_abnormal_mechanical_nocicepti0.97852931
87MP0002295_abnormal_pulmonary_circulatio0.97387261
88MP0008058_abnormal_DNA_repair0.96800250
89MP0002638_abnormal_pupillary_reflex0.96418620
90MP0003693_abnormal_embryo_hatching0.95677015
91MP0000534_abnormal_ureter_morphology0.95286366
92MP0001293_anophthalmia0.92947599
93MP0001502_abnormal_circadian_rhythm0.92427113
94MP0003077_abnormal_cell_cycle0.89832798
95MP0005023_abnormal_wound_healing0.87998116
96MP0002177_abnormal_outer_ear0.87876122
97MP0002938_white_spotting0.87490814
98MP0000750_abnormal_muscle_regeneration0.87398830
99MP0002111_abnormal_tail_morphology0.86069635
100MP0003172_abnormal_lysosome_physiology0.86018499
101MP0010030_abnormal_orbit_morphology0.85991438
102MP0004270_analgesia0.85883639
103MP0004233_abnormal_muscle_weight0.85352439
104MP0001984_abnormal_olfaction0.84184922
105MP0001529_abnormal_vocalization0.83781839
106MP0001963_abnormal_hearing_physiology0.83423570
107MP0006276_abnormal_autonomic_nervous0.82883183
108MP0000569_abnormal_digit_pigmentation0.82727331
109MP0005253_abnormal_eye_physiology0.82476473
110MP0000778_abnormal_nervous_system0.81735958
111MP0003137_abnormal_impulse_conducting0.81425365
112MP0008932_abnormal_embryonic_tissue0.80468416
113MP0004957_abnormal_blastocyst_morpholog0.78623567
114MP0005330_cardiomyopathy0.78612747
115MP0002184_abnormal_innervation0.78438540
116MP0006138_congestive_heart_failure0.77582651
117MP0004084_abnormal_cardiac_muscle0.76266657
118MP0001943_abnormal_respiration0.73913815
119MP0005257_abnormal_intraocular_pressure0.73898508
120MP0005197_abnormal_uvea_morphology0.73685445
121MP0005381_digestive/alimentary_phenotyp0.72572821
122MP0005084_abnormal_gallbladder_morpholo0.72413723
123MP0010386_abnormal_urinary_bladder0.72310665
124MP0002084_abnormal_developmental_patter0.71421180
125MP0004133_heterotaxia0.70975340
126MP0000733_abnormal_muscle_development0.70609133
127MP0005391_vision/eye_phenotype0.69885779
128MP0004145_abnormal_muscle_electrophysio0.69576342
129MP0002067_abnormal_sensory_capabilities0.68950342
130MP0003119_abnormal_digestive_system0.68370710
131MP0004811_abnormal_neuron_physiology0.68189002
132MP0008775_abnormal_heart_ventricle0.67982073
133MP0002736_abnormal_nociception_after0.66163129
134MP0000026_abnormal_inner_ear0.64060146
135MP0004085_abnormal_heartbeat0.63901946
136MP0005595_abnormal_vascular_smooth0.63508586
137MP0003705_abnormal_hypodermis_morpholog0.61840702
138MP0005369_muscle_phenotype0.59380586
139MP0002128_abnormal_blood_circulation0.57771067
140MP0002735_abnormal_chemical_nociception0.55462266
141MP0003880_abnormal_central_pattern0.54831316
142MP0004742_abnormal_vestibular_system0.53809753
143MP0003635_abnormal_synaptic_transmissio0.52954105
144MP0005645_abnormal_hypothalamus_physiol0.52872539
145MP0004197_abnormal_fetal_growth/weight/0.52523416
146MP0003045_fibrosis0.51114713
147MP0000955_abnormal_spinal_cord0.51080013
148MP0005620_abnormal_muscle_contractility0.50807397
149MP0009053_abnormal_anal_canal0.50646144
150MP0000749_muscle_degeneration0.50270351
151MP0002163_abnormal_gland_morphology0.49736159
152MP0005646_abnormal_pituitary_gland0.49522034
153MP0001177_atelectasis0.49339616
154MP0004036_abnormal_muscle_relaxation0.48950832
155MP0002751_abnormal_autonomic_nervous0.48483032
156MP0001968_abnormal_touch/_nociception0.47350085
157MP0000003_abnormal_adipose_tissue0.47097517

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)9.27808085
2Irregular epiphyses (HP:0010582)7.98042671
3Vitreoretinal degeneration (HP:0000655)6.49339961
4Small epiphyses (HP:0010585)6.44444194
5Hypoplastic ischia (HP:0003175)6.13032459
6Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.42380371
7Abnormality of the ischium (HP:0003174)5.40562808
8Flat capital femoral epiphysis (HP:0003370)5.28273062
9Mild short stature (HP:0003502)5.19743271
10Cupped ribs (HP:0000887)5.14816999
11Delayed epiphyseal ossification (HP:0002663)5.10478089
12Abnormal tarsal ossification (HP:0008369)5.07119004
13Metaphyseal cupping (HP:0003021)5.06818507
14Genu varum (HP:0002970)4.84285717
15Neonatal short-limb short stature (HP:0008921)4.70052721
16Flat acetabular roof (HP:0003180)4.38323367
17Metaphyseal dysplasia (HP:0100255)4.13622149
18Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.12615111
19Abnormality of femoral epiphyses (HP:0006499)4.12615111
20Flattened epiphyses (HP:0003071)3.89320921
21Osteoarthritis (HP:0002758)3.87579666
22Abnormality of the vertebral endplates (HP:0005106)3.86906083
23Abnormal foot bone ossification (HP:0010675)3.85443957
24Abnormality of the epiphysis of the femoral head (HP:0010574)3.82400924
25Abnormality of the femoral head (HP:0003368)3.60676364
26Irregular vertebral endplates (HP:0003301)3.56416698
27Short femoral neck (HP:0100864)3.53576797
28Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.51538378
29Absent epiphyses (HP:0010577)3.51538378
30Abnormality of the proximal phalanges of the hand (HP:0009834)3.35813477
31Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.34276648
32Testicular atrophy (HP:0000029)3.30442601
33Arthropathy (HP:0003040)3.26261171
34Abnormality of the pubic bones (HP:0003172)3.15688281
35Abnormality of carpal bone ossification (HP:0006257)3.15195686
36Metaphyseal irregularity (HP:0003025)3.13925018
37Enlarged epiphyses (HP:0010580)3.13809022
38Platyspondyly (HP:0000926)3.11347488
39Mesomelia (HP:0003027)3.09308740
40Barrel-shaped chest (HP:0001552)3.03601850
41Coxa vara (HP:0002812)3.00781139
42Abnormality of the phalanges of the 2nd finger (HP:0009541)2.97828132
43Waddling gait (HP:0002515)2.96463130
44Abnormal vertebral ossification (HP:0100569)2.88648989
45Cervical subluxation (HP:0003308)2.88420041
46Limited hip movement (HP:0008800)2.86705150
47Vertebral clefting (HP:0008428)2.74909379
48Relative macrocephaly (HP:0004482)2.74886188
49Aplasia/hypoplasia of the femur (HP:0005613)2.70564997
50Protuberant abdomen (HP:0001538)2.70402580
51Beaking of vertebral bodies (HP:0004568)2.69619461
52Hypoplasia of the odontoid process (HP:0003311)2.65543936
53Premature rupture of membranes (HP:0001788)2.64938256
54Exostoses (HP:0100777)2.62047662
55Limited elbow extension (HP:0001377)2.59249915
56Abnormal ossification of hand bones (HP:0005921)2.57216057
57Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.55518818
58Ovoid vertebral bodies (HP:0003300)2.55333655
59Carpal bone hypoplasia (HP:0001498)2.55305032
60Abnormal hand bone ossification (HP:0010660)2.55225636
61Hip contracture (HP:0003273)2.54475479
62Lumbar hyperlordosis (HP:0002938)2.50876443
63Glossoptosis (HP:0000162)2.48618450
64Soft skin (HP:0000977)2.44615796
65Aortic dissection (HP:0002647)2.44379351
66Fibular hypoplasia (HP:0003038)2.43751563
67Spinal cord compression (HP:0002176)2.43229386
68Ankle contracture (HP:0006466)2.40176834
69Coronal craniosynostosis (HP:0004440)2.37557876
70Abnormality of the middle phalanges of the toes (HP:0010183)2.36240787
71Birth length less than 3rd percentile (HP:0003561)2.35645017
72Stillbirth (HP:0003826)2.33269891
73Bladder diverticulum (HP:0000015)2.31923199
74Abnormality of the 2nd finger (HP:0004100)2.30368477
75Mesangial abnormality (HP:0001966)2.28276312
76Ulnar bowing (HP:0003031)2.28246956
77Thoracolumbar scoliosis (HP:0002944)2.27326102
78Broad long bones (HP:0005622)2.26882557
79Absent frontal sinuses (HP:0002688)2.26193034
80Abnormality of the odontoid process (HP:0003310)2.25325125
81Abnormality of dentin (HP:0010299)2.24897126
82Broad phalanx (HP:0006009)2.24836268
83Micromelia (HP:0002983)2.22067555
84Abnormality of incisor morphology (HP:0011063)2.21875473
85Rhizomelia (HP:0008905)2.21223362
86Short middle phalanx of finger (HP:0005819)2.20798049
87Shallow orbits (HP:0000586)2.17263324
88Abnormality of the vitreous humor (HP:0004327)2.16797368
89Vascular tortuosity (HP:0004948)2.15966203
90Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.14709467
91Rib fusion (HP:0000902)2.13383513
92Mixed hearing impairment (HP:0000410)2.11827867
93Thin ribs (HP:0000883)2.11698649
94Arterial tortuosity (HP:0005116)2.11222152
95Flared metaphyses (HP:0003015)2.05694012
96Abnormality of the acetabulum (HP:0003170)2.03329276
97Inability to walk (HP:0002540)2.02723820
98Broad thumb (HP:0011304)2.00308810
99Congenital stationary night blindness (HP:0007642)1.97962354
100Disproportionate short-trunk short stature (HP:0003521)1.97188084
101Protrusio acetabuli (HP:0003179)1.97160913
102Type II lissencephaly (HP:0007260)1.96690531
103Abnormality of the phalanges of the 5th finger (HP:0004213)1.96140482
104Hypoplastic pelvis (HP:0008839)1.95244172
105Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.95122464
106Aortic aneurysm (HP:0004942)1.94624825
107Bowel diverticulosis (HP:0005222)1.94534958
108Delayed gross motor development (HP:0002194)1.94020918
109Akinesia (HP:0002304)1.93730891
110Hypoplastic ilia (HP:0000946)1.92585239
111Retinal dysplasia (HP:0007973)1.92188543
112Abnormality of the middle phalanges of the hand (HP:0009833)1.91545295
113Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.91090381
114Myotonia (HP:0002486)1.90279480
115Broad phalanges of the hand (HP:0009768)1.89868199
116Radial bowing (HP:0002986)1.89479824
117Short ribs (HP:0000773)1.88918966
118Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.87290360
119Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.86788400
120Patellar aplasia (HP:0006443)1.85497788
121Attenuation of retinal blood vessels (HP:0007843)1.85193445
122Broad finger (HP:0001500)1.84939173
123Annular pancreas (HP:0001734)1.84816196
124Long clavicles (HP:0000890)1.84564102
125Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.83662690
126Facial diplegia (HP:0001349)1.83433937
127Drooling (HP:0002307)1.82790029
128Genu recurvatum (HP:0002816)1.82530747
129Colon cancer (HP:0003003)1.75422048
130Aplasia/Hypoplasia of the patella (HP:0006498)1.75304331
131Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75154633
132Small hand (HP:0200055)1.70784802
133Wrist flexion contracture (HP:0001239)1.67725625
134Turricephaly (HP:0000262)1.67587909
135Cerebral hypomyelination (HP:0006808)1.66565112
136Spinal rigidity (HP:0003306)1.66474085
137Renal duplication (HP:0000075)1.66231959
138Abnormality of the lower motor neuron (HP:0002366)1.65353102
139Focal seizures (HP:0007359)1.62826904
140Follicular hyperkeratosis (HP:0007502)1.61157892
141Chorioretinal atrophy (HP:0000533)1.60844298
142Abnormality of the intrinsic pathway (HP:0010989)1.59954503
143Focal motor seizures (HP:0011153)1.58498296
144Bowed forearm bones (HP:0003956)1.56243832
145Bowing of the arm (HP:0006488)1.56243832
146Decreased central vision (HP:0007663)1.55101186
147Choroideremia (HP:0001139)1.53228762
148Neonatal respiratory distress (HP:0002643)1.53088662
149Cerebellar dysplasia (HP:0007033)1.52994305
150Broad distal phalanx of finger (HP:0009836)1.52275337
151Molar tooth sign on MRI (HP:0002419)1.52233018
152Abnormality of midbrain morphology (HP:0002418)1.52233018
153Short nail (HP:0001799)1.51933890
154Abnormality of the astrocytes (HP:0100707)1.51596542
155Astrocytoma (HP:0009592)1.51596542
156Short chin (HP:0000331)1.49921201
157Broad metatarsal (HP:0001783)1.49772143
158Wormian bones (HP:0002645)1.47124546
159Atrioventricular block (HP:0001678)1.45863257
160Overgrowth (HP:0001548)1.45456998
161Excessive salivation (HP:0003781)1.44677296
162Broad ribs (HP:0000885)1.43200131
163Overriding aorta (HP:0002623)1.42487782
164Mitral stenosis (HP:0001718)1.41702125
165Insomnia (HP:0100785)1.40666893
166Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.40595479
167Abnormality of the umbilical cord (HP:0010881)1.39356504
168Keratoconus (HP:0000563)1.39284956
169Increased corneal curvature (HP:0100692)1.39284956
170Abnormality of the 4th metacarpal (HP:0010012)1.38560847
171Reduced subcutaneous adipose tissue (HP:0003758)1.38487229
172Aortic valve stenosis (HP:0001650)1.36876855
173Glioma (HP:0009733)1.36270543
174Ectopic kidney (HP:0000086)1.35911785
175Anophthalmia (HP:0000528)1.35896227
176Hypoventilation (HP:0002791)1.35608133
177Diminished movement (HP:0002374)1.35338881
178Pterygium (HP:0001059)1.35299241
179Hydroureter (HP:0000072)1.34965606
180Increased hepatocellular lipid droplets (HP:0006565)1.31213105
181Non-midline cleft lip (HP:0100335)1.30977911
182Hyperextensible skin (HP:0000974)1.30824958
183Occipital encephalocele (HP:0002085)1.30743439
184Breast hypoplasia (HP:0003187)1.29645652
185Hemiparesis (HP:0001269)1.28910067
186Tibial bowing (HP:0002982)1.28301383
187Generalized tonic-clonic seizures (HP:0002069)1.27503807
188Increased circulating renin level (HP:0000848)1.27185039
189Hyperalaninemia (HP:0003348)1.27124506

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR28.62214153
2STK244.02942699
3TAOK13.81830303
4PDGFRA3.20408103
5ERBB33.20296468
6CASK3.05422560
7STK38L2.93335313
8TSSK62.67744247
9PRKG22.56003237
10BUB12.47474796
11MAP3K32.42984529
12PNCK2.39900632
13TIE12.34480636
14BMPR1B2.22739474
15VRK22.05467626
16MYLK2.02973740
17NTRK31.98301312
18SIK11.91349935
19NEK61.84699016
20DMPK1.73524858
21NEK11.71573776
22PLK31.69182982
23TTK1.62148305
24TRIM281.56654781
25CDK81.53354870
26PDGFRB1.51494568
27PLK21.46797042
28MAPK71.43445855
29MARK11.38432834
30NTRK11.36468641
31TTN1.34703983
32PHKG21.33835913
33PHKG11.33835913
34CDC71.31860650
35ROCK11.26884875
36WEE11.22641546
37TGFBR11.19924208
38PLK11.18642569
39FRK1.18471970
40NUAK11.16975284
41MINK11.15876437
42PDK21.12602968
43TYRO31.11716607
44STK381.09666959
45BRSK11.09093013
46STK161.08566546
47SRPK11.05990632
48CAMKK21.05345517
49PAK21.04246291
50NTRK21.04234727
51MKNK21.02874176
52CSNK1G11.01715955
53MAPK150.98793847
54EPHA40.97922354
55ICK0.95788278
56BCR0.95090390
57CSNK1G20.94903343
58PRKD30.94200817
59CSNK1G30.93680393
60CHEK20.92576794
61PTK2B0.91596401
62CDK180.91477632
63DAPK20.89383900
64ADRBK10.88795892
65CDK150.87518733
66NME10.86539809
67PIK3CA0.86360239
68MAP3K40.85173517
69MELK0.84954512
70MET0.84907377
71PLK40.83184595
72CCNB10.81899339
73CDK140.81538366
74TAF10.81331802
75TRPM70.81110389
76ILK0.80563228
77EPHB20.79632902
78CDK11A0.79411711
79ERBB40.78203482
80LATS20.77984500
81ZAK0.76202197
82TLK10.73963782
83MAPK120.73759425
84KIT0.73706695
85GRK50.72972982
86CDC42BPA0.72065064
87INSRR0.70189538
88ADRBK20.68722348
89RIPK10.68416149
90PAK40.67939924
91WNK40.67097163
92CAMK2B0.66942898
93AURKB0.66890269
94PBK0.65428866
95WNK10.63872053
96CAMK2D0.63808983
97MUSK0.62562746
98BRSK20.61660665
99NEK20.61450119
100LATS10.60352338
101STK390.60016475
102MKNK10.59629253
103EIF2AK10.58635108
104SIK20.58454752
105LIMK10.57855032
106EPHA20.57503235
107PAK30.56584105
108MOS0.56505865
109AURKA0.55484898
110VRK10.54635177
111LMTK20.53622389
112ATR0.53143111
113STK30.52784449
114CAMK2G0.52546633
115MAP4K20.51295490
116MAP2K70.51185929
117CAMK1G0.50085805
118ABL20.49855777
119INSR0.49327541
120PAK10.48161701
121FGFR10.47492664
122TNIK0.46871633
123PRKG10.46329068
124GSK3A0.46054327
125EPHA30.44638013
126ROCK20.43915809
127CAMKK10.43779762
128IGF1R0.42866670
129PTK20.40768375
130CAMK1D0.40623484
131RET0.39225736
132TRIB30.38991627
133EIF2AK30.36079410
134MAPK130.35752073
135PRKCE0.35185090
136DYRK1A0.34902910
137EPHB10.34828872
138MAP2K10.33979449
139PDK40.31659208
140PDK30.31659208
141SGK10.30924481
142FER0.30481842
143TAOK20.30103790
144PAK60.29208473
145PRPF4B0.29122417
146MAPK40.29048667
147CAMK2A0.28572282
148CSNK1A1L0.26796746
149TESK10.26375077
150PRKACA0.26210087
151MST40.23867786
152PIK3CG0.23799084
153CAMK10.23064969
154PRKACG0.21700019
155CDK50.21513963
156MAPK100.20324876
157MAPKAPK50.19152928
158ABL10.19033385
159PRKCG0.18834647
160FES0.17690433

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005325.97626110
2ECM-receptor interaction_Homo sapiens_hsa045125.80862184
3Protein digestion and absorption_Homo sapiens_hsa049744.65040028
4Focal adhesion_Homo sapiens_hsa045102.83684496
5Sphingolipid metabolism_Homo sapiens_hsa006002.25146098
6Olfactory transduction_Homo sapiens_hsa047402.22380869
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.96172100
8Other glycan degradation_Homo sapiens_hsa005111.84817114
9PI3K-Akt signaling pathway_Homo sapiens_hsa041511.82752643
10Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.75521806
11DNA replication_Homo sapiens_hsa030301.70321559
12Non-homologous end-joining_Homo sapiens_hsa034501.70199131
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.69628391
14Selenocompound metabolism_Homo sapiens_hsa004501.64787572
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61080559
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.57033276
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.56647362
18RNA polymerase_Homo sapiens_hsa030201.55005865
19Basal transcription factors_Homo sapiens_hsa030221.52417782
20Dilated cardiomyopathy_Homo sapiens_hsa054141.52260852
21Sulfur metabolism_Homo sapiens_hsa009201.51236756
22Gap junction_Homo sapiens_hsa045401.51158382
23TGF-beta signaling pathway_Homo sapiens_hsa043501.48812669
24One carbon pool by folate_Homo sapiens_hsa006701.44614709
25Mismatch repair_Homo sapiens_hsa034301.44417044
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.43980742
27cGMP-PKG signaling pathway_Homo sapiens_hsa040221.41179413
28Homologous recombination_Homo sapiens_hsa034401.37128722
29Fanconi anemia pathway_Homo sapiens_hsa034601.36013710
30Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.34751303
31Malaria_Homo sapiens_hsa051441.33043600
32Vitamin B6 metabolism_Homo sapiens_hsa007501.29064148
33Nucleotide excision repair_Homo sapiens_hsa034201.28853122
34Renin secretion_Homo sapiens_hsa049241.28299395
35Cell cycle_Homo sapiens_hsa041101.28195021
36Salivary secretion_Homo sapiens_hsa049701.23402412
37Dorso-ventral axis formation_Homo sapiens_hsa043201.21235285
38Proteasome_Homo sapiens_hsa030501.19463325
39Long-term depression_Homo sapiens_hsa047301.19226573
40Hedgehog signaling pathway_Homo sapiens_hsa043401.18750623
41Circadian entrainment_Homo sapiens_hsa047131.17681472
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15340046
43Sulfur relay system_Homo sapiens_hsa041221.13641570
44Axon guidance_Homo sapiens_hsa043601.13385923
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12191755
46Phototransduction_Homo sapiens_hsa047441.11898353
47Hippo signaling pathway_Homo sapiens_hsa043901.11493827
48Pyrimidine metabolism_Homo sapiens_hsa002401.11391709
49Oxytocin signaling pathway_Homo sapiens_hsa049211.11166348
50Amphetamine addiction_Homo sapiens_hsa050311.09257992
51Cholinergic synapse_Homo sapiens_hsa047251.09241349
52RNA transport_Homo sapiens_hsa030131.05315577
53Cocaine addiction_Homo sapiens_hsa050301.05172492
54Proteoglycans in cancer_Homo sapiens_hsa052051.05097691
55Vascular smooth muscle contraction_Homo sapiens_hsa042701.02265650
56Circadian rhythm_Homo sapiens_hsa047100.99406043
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97584106
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97076385
59Basal cell carcinoma_Homo sapiens_hsa052170.95230724
60Purine metabolism_Homo sapiens_hsa002300.93076864
61Glioma_Homo sapiens_hsa052140.92438917
62MicroRNAs in cancer_Homo sapiens_hsa052060.89985613
63Cardiac muscle contraction_Homo sapiens_hsa042600.89249306
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87979780
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87599793
66Ovarian steroidogenesis_Homo sapiens_hsa049130.85930754
67Dopaminergic synapse_Homo sapiens_hsa047280.84808340
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83677712
69Thyroid hormone synthesis_Homo sapiens_hsa049180.83654519
70Base excision repair_Homo sapiens_hsa034100.83118732
71Amoebiasis_Homo sapiens_hsa051460.82832286
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.82611822
73Estrogen signaling pathway_Homo sapiens_hsa049150.81556225
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.81500995
75Oocyte meiosis_Homo sapiens_hsa041140.78253128
76Glutamatergic synapse_Homo sapiens_hsa047240.78096032
77Prostate cancer_Homo sapiens_hsa052150.77523359
78Serotonergic synapse_Homo sapiens_hsa047260.76858997
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75679213
80Nitrogen metabolism_Homo sapiens_hsa009100.74407419
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74282934
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74055899
83GnRH signaling pathway_Homo sapiens_hsa049120.73803826
84Melanogenesis_Homo sapiens_hsa049160.73606645
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72892937
86Pyruvate metabolism_Homo sapiens_hsa006200.72435575
87Gastric acid secretion_Homo sapiens_hsa049710.72294178
88Calcium signaling pathway_Homo sapiens_hsa040200.72207936
89cAMP signaling pathway_Homo sapiens_hsa040240.71703143
90Vibrio cholerae infection_Homo sapiens_hsa051100.71055976
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70171709
92p53 signaling pathway_Homo sapiens_hsa041150.69600770
93Morphine addiction_Homo sapiens_hsa050320.69593841
94Insulin secretion_Homo sapiens_hsa049110.69465025
95RNA degradation_Homo sapiens_hsa030180.68829105
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68653227
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67661905
98Choline metabolism in cancer_Homo sapiens_hsa052310.67500362
99Platelet activation_Homo sapiens_hsa046110.65883019
100MAPK signaling pathway_Homo sapiens_hsa040100.65659283
101Arginine and proline metabolism_Homo sapiens_hsa003300.65611792
102Lysine degradation_Homo sapiens_hsa003100.65220102
103Wnt signaling pathway_Homo sapiens_hsa043100.65160070
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64451248
105Fatty acid elongation_Homo sapiens_hsa000620.63766764
106Huntingtons disease_Homo sapiens_hsa050160.62220353
107Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61661492
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60332902
109Butanoate metabolism_Homo sapiens_hsa006500.60082906
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59415648
111Oxidative phosphorylation_Homo sapiens_hsa001900.59102831
112Phagosome_Homo sapiens_hsa041450.58339023
113Folate biosynthesis_Homo sapiens_hsa007900.57878795
114Melanoma_Homo sapiens_hsa052180.56806920
115Adherens junction_Homo sapiens_hsa045200.53756645
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53210266
117Starch and sucrose metabolism_Homo sapiens_hsa005000.50984300
118ErbB signaling pathway_Homo sapiens_hsa040120.50796477
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50707562
120Steroid biosynthesis_Homo sapiens_hsa001000.50502290
121Nicotine addiction_Homo sapiens_hsa050330.50185033
122Glucagon signaling pathway_Homo sapiens_hsa049220.49608690
123Renal cell carcinoma_Homo sapiens_hsa052110.47693856
124Protein export_Homo sapiens_hsa030600.47273016
125GABAergic synapse_Homo sapiens_hsa047270.46424116
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.46306643
127Rap1 signaling pathway_Homo sapiens_hsa040150.45890506
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44876385
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.42895237
130Ras signaling pathway_Homo sapiens_hsa040140.42534446
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42040458
132Synaptic vesicle cycle_Homo sapiens_hsa047210.42038271
133N-Glycan biosynthesis_Homo sapiens_hsa005100.39652366
134Long-term potentiation_Homo sapiens_hsa047200.38920653
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38540450
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.37675595
137Tight junction_Homo sapiens_hsa045300.37588378
138Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37366510
139Pathways in cancer_Homo sapiens_hsa052000.36742069
140Rheumatoid arthritis_Homo sapiens_hsa053230.33731065
141Small cell lung cancer_Homo sapiens_hsa052220.33641610
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32400223
143Type II diabetes mellitus_Homo sapiens_hsa049300.31343404
144Taste transduction_Homo sapiens_hsa047420.30981773

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