SUPT6H

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)4.20690625
2Golgi transport vesicle coating (GO:0048200)4.20690625
3negative regulation of erythrocyte differentiation (GO:0045647)3.89457465
4protein localization to endosome (GO:0036010)3.64109427
5adherens junction assembly (GO:0034333)3.58541652
6cell-substrate adherens junction assembly (GO:0007045)3.55246920
7focal adhesion assembly (GO:0048041)3.55246920
8mannose metabolic process (GO:0006013)3.53984247
9nuclear pore complex assembly (GO:0051292)3.42642232
10cell-substrate junction assembly (GO:0007044)3.32879886
11regulation of NFAT protein import into nucleus (GO:0051532)3.31298672
12cytoskeletal anchoring at plasma membrane (GO:0007016)3.25495919
13embryonic process involved in female pregnancy (GO:0060136)3.10367828
14regulation of glucose import in response to insulin stimulus (GO:2001273)3.10142677
15retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.05881431
16skin morphogenesis (GO:0043589)3.05289195
17response to laminar fluid shear stress (GO:0034616)3.02250646
18regulation of early endosome to late endosome transport (GO:2000641)3.01901524
19histone H3-K36 demethylation (GO:0070544)2.91536608
20insulin-like growth factor receptor signaling pathway (GO:0048009)2.90470067
21activation of Rac GTPase activity (GO:0032863)2.86900295
22stress fiber assembly (GO:0043149)2.84945859
23positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.83285094
24negative regulation of fatty acid transport (GO:2000192)2.79303681
25negative regulation of cell size (GO:0045792)2.78755424
26pinocytosis (GO:0006907)2.77320076
27basement membrane organization (GO:0071711)2.76234970
28activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.71766144
293-UTR-mediated mRNA stabilization (GO:0070935)2.71355648
30spliceosomal tri-snRNP complex assembly (GO:0000244)2.69455201
31modulation by symbiont of host cellular process (GO:0044068)2.69296983
32positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.69121764
33epithelial cell differentiation involved in prostate gland development (GO:0060742)2.68019016
34regulation of cholesterol homeostasis (GO:2000188)2.64921626
35positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.62238261
36maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.62215158
37positive regulation of blood vessel endothelial cell migration (GO:0043536)2.61505763
38regulation of extracellular matrix disassembly (GO:0010715)2.61075327
39positive regulation of nuclease activity (GO:0032075)2.60989614
40RNA stabilization (GO:0043489)2.58843643
41mRNA stabilization (GO:0048255)2.58843643
42apoptotic process involved in morphogenesis (GO:0060561)2.58331410
43nuclear pore organization (GO:0006999)2.57870241
44glucocorticoid receptor signaling pathway (GO:0042921)2.57362261
45cellular response to epidermal growth factor stimulus (GO:0071364)2.57325765
46regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.57272706
47positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.56171101
48hemidesmosome assembly (GO:0031581)2.55434997
49regulation of mammary gland epithelial cell proliferation (GO:0033599)2.55332467
50positive regulation of extracellular matrix organization (GO:1903055)2.52647679
51semaphorin-plexin signaling pathway (GO:0071526)2.51842158
52cortical actin cytoskeleton organization (GO:0030866)2.51194776
53pore complex assembly (GO:0046931)2.48824775
54epithelial cell-cell adhesion (GO:0090136)2.48358178
55endoplasmic reticulum unfolded protein response (GO:0030968)2.47726741
56protein retention in ER lumen (GO:0006621)2.46541876
57branching involved in mammary gland duct morphogenesis (GO:0060444)2.45721693
58regulation of type I interferon-mediated signaling pathway (GO:0060338)2.44199175
59ER-nucleus signaling pathway (GO:0006984)2.43957971
60vesicle coating (GO:0006901)2.43935304
61planar cell polarity pathway involved in neural tube closure (GO:0090179)2.43615578
62response to epidermal growth factor (GO:0070849)2.43368344
63mammary gland epithelial cell proliferation (GO:0033598)2.40309401
64* regulation of nucleobase-containing compound transport (GO:0032239)2.37387144
65regulation of nuclease activity (GO:0032069)2.36672981
66cellular response to virus (GO:0098586)2.35718110
67mitotic chromosome condensation (GO:0007076)2.34986785
68response to muramyl dipeptide (GO:0032495)2.34967286
69positive regulation of histone deacetylation (GO:0031065)2.34855213
70intracellular estrogen receptor signaling pathway (GO:0030520)2.34699544
71maternal placenta development (GO:0001893)2.33223489
72COPII vesicle coating (GO:0048208)2.33222422
73histone lysine demethylation (GO:0070076)2.33080561
74negative regulation of viral release from host cell (GO:1902187)2.32955970
75corticosteroid receptor signaling pathway (GO:0031958)2.30867482
76positive regulation of Cdc42 GTPase activity (GO:0043089)2.30586806
77positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.30445021
78regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.29737955
79barbed-end actin filament capping (GO:0051016)2.29690533
80modulation by virus of host process (GO:0019054)2.28784886
81embryonic eye morphogenesis (GO:0048048)2.27016403
82histone demethylation (GO:0016577)2.26971810
83positive regulation of receptor recycling (GO:0001921)2.26619248
84endothelial cell chemotaxis (GO:0035767)2.26478887
85cellular response to unfolded protein (GO:0034620)2.26057282
86cell adhesion mediated by integrin (GO:0033627)2.25594818
87hypotonic response (GO:0006971)2.24950534
88regulation of ARF protein signal transduction (GO:0032012)2.24947302
89desmosome organization (GO:0002934)2.22982664
90low-density lipoprotein particle clearance (GO:0034383)2.21755635
91protein export from nucleus (GO:0006611)2.21709275
92modulation by virus of host morphology or physiology (GO:0019048)2.21163349
93regulation of extracellular matrix organization (GO:1903053)2.20708711
94germinal center formation (GO:0002467)2.20279034
95atrioventricular valve morphogenesis (GO:0003181)2.18545065
96embryonic camera-type eye morphogenesis (GO:0048596)2.18194730
97positive regulation of keratinocyte differentiation (GO:0045618)2.18063469
98regulation of integrin activation (GO:0033623)2.18006082
99dosage compensation (GO:0007549)2.16863047
100vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.14322806

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.76923863
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.47098285
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.35557051
4MYC_22102868_ChIP-Seq_BL_Human3.12309497
5VDR_21846776_ChIP-Seq_THP-1_Human2.53595803
6ELK3_25401928_ChIP-Seq_HUVEC_Human2.48548442
7KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.38997873
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.38928072
9E2F7_22180533_ChIP-Seq_HELA_Human2.34553966
10TCF7_22412390_ChIP-Seq_EML_Mouse2.33206960
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20261486
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.19131651
13LXR_22292898_ChIP-Seq_THP-1_Human2.17459509
14CLOCK_20551151_ChIP-Seq_293T_Human2.10468922
15KDM2B_26808549_Chip-Seq_DND41_Human2.04652529
16RACK7_27058665_Chip-Seq_MCF-7_Human2.02990462
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.02508245
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.01098717
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96120732
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.88979558
21* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87185997
22ZNF263_19887448_ChIP-Seq_K562_Human1.81728020
23KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.81651445
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.80817002
25KDM2B_26808549_Chip-Seq_K562_Human1.75670619
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.75412727
27RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.72278557
28KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.65657603
29P300_27058665_Chip-Seq_ZR-75-30cells_Human1.65168822
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56917340
31VDR_24763502_ChIP-Seq_THP-1_Human1.53791018
32KDM2B_26808549_Chip-Seq_JURKAT_Human1.53750170
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53376884
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.52222091
35MAF_26560356_Chip-Seq_TH1_Human1.51933685
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51620535
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47996990
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47604678
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45097860
40TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43825946
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42370122
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41152690
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38936866
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.34126235
45NCOR1_26117541_ChIP-Seq_K562_Human1.33934358
46DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33358636
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33305749
48CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.33010690
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32016893
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31839034
51TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31786953
52ATF3_27146783_Chip-Seq_COLON_Human1.31578719
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.31024124
54SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29373822
55EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26861682
56UTX_26944678_Chip-Seq_JUKART_Human1.26795759
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25372513
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25179041
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24792507
60RUNX1_27514584_Chip-Seq_MCF-7_Human1.24366746
61UBF1/2_26484160_Chip-Seq_HMECs_Human1.24182941
62MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23950493
63* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23581614
64ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22186840
65CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21860165
66ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.18904887
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18633747
68MAF_26560356_Chip-Seq_TH2_Human1.17365515
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15558382
70CREB1_26743006_Chip-Seq_LNCaP_Human1.14792843
71* TP53_22127205_ChIP-Seq_IMR90_Human1.12768525
72CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11233527
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11051440
74* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10589014
75SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10437622
76SPI1_23127762_ChIP-Seq_K562_Human1.10413549
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.09956406
78GATA1_19941826_ChIP-Seq_K562_Human1.09529591
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09519366
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09384889
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.09006211
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07807569
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06368602
84SMC4_20622854_ChIP-Seq_HELA_Human1.05962078
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04732762
86SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02752809
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.01190934
88NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01075215
89SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00583845
90SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00583845
91NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00212118
92PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99914016
93STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99370999
94TBX20_22080862_ChIP-Seq_HEART_Mouse0.99014531
95TBX20_22328084_ChIP-Seq_HEART_Mouse0.99014531
96SA1_27219007_Chip-Seq_ERYTHROID_Human0.98522136
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98152772
98P68_20966046_ChIP-Seq_HELA_Human0.95575702
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95352783
100HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93837901

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.41538957
2MP0005076_abnormal_cell_differentiation3.01488700
3MP0005451_abnormal_body_composition2.90669745
4MP0003566_abnormal_cell_adhesion2.80945564
5MP0008438_abnormal_cutaneous_collagen2.77265741
6MP0002877_abnormal_melanocyte_morpholog2.76739453
7MP0005058_abnormal_lysosome_morphology2.55055860
8MP0003300_gastrointestinal_ulcer2.36667386
9MP0003091_abnormal_cell_migration2.19855476
10MP0010352_gastrointestinal_tract_polyps2.09805336
11MP0005409_darkened_coat_color2.03230592
12MP0009840_abnormal_foam_cell1.94945073
13MP0004185_abnormal_adipocyte_glucose1.93349247
14MP0010234_abnormal_vibrissa_follicle1.93156081
15MP0001849_ear_inflammation1.90518715
16MP0005257_abnormal_intraocular_pressure1.88867445
17MP0003453_abnormal_keratinocyte_physiol1.87024910
18MP0003303_peritoneal_inflammation1.86526096
19MP0003172_abnormal_lysosome_physiology1.86175056
20MP0004233_abnormal_muscle_weight1.82389172
21MP0003436_decreased_susceptibility_to1.76195707
22MP0004947_skin_inflammation1.69200040
23MP0008260_abnormal_autophagy1.60661827
24MP0009278_abnormal_bone_marrow1.57709968
25MP0001348_abnormal_lacrimal_gland1.54778592
26MP0004858_abnormal_nervous_system1.53635239
27MP0003191_abnormal_cellular_cholesterol1.51980868
28MP0004264_abnormal_extraembryonic_tissu1.51739634
29MP0002396_abnormal_hematopoietic_system1.49805031
30MP0004808_abnormal_hematopoietic_stem1.48519049
31MP0000858_altered_metastatic_potential1.47651915
32MP0005023_abnormal_wound_healing1.36196616
33MP0004272_abnormal_basement_membrane1.34804899
34MP0002060_abnormal_skin_morphology1.33770229
35MP0000733_abnormal_muscle_development1.33578673
36MP0002009_preneoplasia1.32887494
37MP0002796_impaired_skin_barrier1.31113314
38MP0001915_intracranial_hemorrhage1.28979703
39MP0003763_abnormal_thymus_physiology1.27652458
40MP0001958_emphysema1.27230201
41MP0005666_abnormal_adipose_tissue1.25455006
42MP0002089_abnormal_postnatal_growth/wei1.23566144
43MP0003279_aneurysm1.19432966
44MP0001730_embryonic_growth_arrest1.19138721
45MP0000003_abnormal_adipose_tissue1.18747665
46MP0005375_adipose_tissue_phenotype1.18364942
47MP0000767_abnormal_smooth_muscle1.17609652
48MP0005621_abnormal_cell_physiology1.17006889
49MP0002998_abnormal_bone_remodeling1.15209994
50MP0005275_abnormal_skin_tensile1.12714971
51MP0000537_abnormal_urethra_morphology1.10554835
52MP0000678_abnormal_parathyroid_gland1.08696501
53MP0002166_altered_tumor_susceptibility1.07037922
54MP0003828_pulmonary_edema1.05308766
55MP0010630_abnormal_cardiac_muscle1.01785737
56MP0003329_amyloid_beta_deposits1.01156255
57MP0005623_abnormal_meninges_morphology0.98952188
58MP0002086_abnormal_extraembryonic_tissu0.97188751
59MP0001216_abnormal_epidermal_layer0.94377862
60MP0010307_abnormal_tumor_latency0.94162187
61MP0002896_abnormal_bone_mineralization0.93954432
62MP0009672_abnormal_birth_weight0.93165318
63MP0004510_myositis0.92415005
64MP0005501_abnormal_skin_physiology0.92103679
65MP0000747_muscle_weakness0.91116357
66MP0003656_abnormal_erythrocyte_physiolo0.89726741
67MP0009333_abnormal_splenocyte_physiolog0.88248353
68MP0000350_abnormal_cell_proliferation0.88050587
69MP0004087_abnormal_muscle_fiber0.87797302
70MP0001873_stomach_inflammation0.87588191
71MP0003115_abnormal_respiratory_system0.85459275
72MP0003984_embryonic_growth_retardation0.84950344
73MP0000759_abnormal_skeletal_muscle0.84803225
74MP0009931_abnormal_skin_appearance0.84054770
75MP0000685_abnormal_immune_system0.83961042
76MP0003111_abnormal_nucleus_morphology0.83948142
77MP0001533_abnormal_skeleton_physiology0.83201598
78MP0000751_myopathy0.82812829
79MP0001851_eye_inflammation0.79977842
80MP0002088_abnormal_embryonic_growth/wei0.79435532
81MP0002080_prenatal_lethality0.78850995
82MP0001853_heart_inflammation0.78654612
83MP0006138_congestive_heart_failure0.77704024
84MP0003045_fibrosis0.77445287
85MP0002419_abnormal_innate_immunity0.75468815
86MP0002254_reproductive_system_inflammat0.75252963
87MP0003448_altered_tumor_morphology0.75054966
88MP0005380_embryogenesis_phenotype0.74925258
89MP0001672_abnormal_embryogenesis/_devel0.74925258
90MP0000703_abnormal_thymus_morphology0.74167384
91MP0002925_abnormal_cardiovascular_devel0.73421817
92MP0005384_cellular_phenotype0.72059329
93MP0002006_tumorigenesis0.71417456
94MP0001545_abnormal_hematopoietic_system0.70421906
95MP0005397_hematopoietic_system_phenotyp0.70421906
96MP0008057_abnormal_DNA_replication0.69570643
97MP0004782_abnormal_surfactant_physiolog0.69547637
98MP0005464_abnormal_platelet_physiology0.69368078
99MP0000627_abnormal_mammary_gland0.68237568
100MP0001661_extended_life_span0.67787925

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.43370704
2Hyperacusis (HP:0010780)3.28544045
3Premature rupture of membranes (HP:0001788)3.07936838
4Broad face (HP:0000283)2.97180548
5Cerebral aneurysm (HP:0004944)2.64972692
6Increased connective tissue (HP:0009025)2.57568782
7Vertebral compression fractures (HP:0002953)2.52875712
8Obstructive sleep apnea (HP:0002870)2.52492078
9Distal lower limb amyotrophy (HP:0008944)2.47106779
10Flat acetabular roof (HP:0003180)2.43686479
11Abnormality of the fingertips (HP:0001211)2.41948158
12Disproportionate tall stature (HP:0001519)2.27819746
13Ulnar bowing (HP:0003031)2.25449809
14Asymmetry of the thorax (HP:0001555)2.24224054
15Achilles tendon contracture (HP:0001771)2.23175973
16Aneurysm (HP:0002617)2.20897905
17Ankyloglossia (HP:0010296)2.18156401
18Deep venous thrombosis (HP:0002625)2.11315674
19Cervical subluxation (HP:0003308)2.11096123
20Dysmetric saccades (HP:0000641)2.10349748
21Shallow orbits (HP:0000586)2.09045244
22Abnormality of the Achilles tendon (HP:0005109)2.07255964
23Thin bony cortex (HP:0002753)2.06784352
24Osteolytic defects of the phalanges of the hand (HP:0009771)2.06037323
25Osteolytic defects of the hand bones (HP:0009699)2.06037323
26Abnormality of oral frenula (HP:0000190)2.03511437
27Dilatation of the ascending aorta (HP:0005111)2.02291602
28Fragile skin (HP:0001030)2.01433188
29Centrally nucleated skeletal muscle fibers (HP:0003687)2.01063701
30Sparse lateral eyebrow (HP:0005338)2.00887588
31Insomnia (HP:0100785)2.00308282
32Dislocated radial head (HP:0003083)1.98913048
33Aortic aneurysm (HP:0004942)1.98796629
34Arterial tortuosity (HP:0005116)1.96672664
35Abnormality of the distal phalanx of the thumb (HP:0009617)1.95297916
36Wormian bones (HP:0002645)1.95147638
37Persistence of primary teeth (HP:0006335)1.93876071
38Advanced eruption of teeth (HP:0006288)1.92586246
39Cerebral inclusion bodies (HP:0100314)1.92075714
40Spinal cord lesions (HP:0100561)1.92066390
41Syringomyelia (HP:0003396)1.92066390
42Bladder diverticulum (HP:0000015)1.89696102
43Mitral valve prolapse (HP:0001634)1.88618052
44Distal upper limb amyotrophy (HP:0007149)1.88265485
45Upper limb amyotrophy (HP:0009129)1.88265485
46Vascular tortuosity (HP:0004948)1.87451925
47Hemorrhage of the eye (HP:0011885)1.87021347
48Long eyelashes (HP:0000527)1.86714034
49Atrophic scars (HP:0001075)1.85236127
50Long palpebral fissure (HP:0000637)1.84578617
51Blue sclerae (HP:0000592)1.82823042
52Abnormality of the radial head (HP:0003995)1.82803700
53Biconcave vertebral bodies (HP:0004586)1.82140287
54Mitral regurgitation (HP:0001653)1.82123551
55Abnormality of the thoracic spine (HP:0100711)1.81903485
56Interstitial pulmonary disease (HP:0006530)1.80112273
57Subacute progressive viral hepatitis (HP:0006572)1.79662201
58Lower limb amyotrophy (HP:0007210)1.77757724
59Dysostosis multiplex (HP:0000943)1.76164515
60Short nail (HP:0001799)1.75280344
61Spinal rigidity (HP:0003306)1.74632421
62Spondylolisthesis (HP:0003302)1.74335276
63Myocardial infarction (HP:0001658)1.71490801
64Increased variability in muscle fiber diameter (HP:0003557)1.71322341
65Patellar dislocation (HP:0002999)1.70208075
66Heterotopia (HP:0002282)1.68829142
67Macroorchidism (HP:0000053)1.67306695
68Distal lower limb muscle weakness (HP:0009053)1.66767131
69Segmental peripheral demyelination/remyelination (HP:0003481)1.66367830
70Eczematoid dermatitis (HP:0000976)1.65206588
71Genu recurvatum (HP:0002816)1.65101456
72Cellulitis (HP:0100658)1.63091051
73Aortic dissection (HP:0002647)1.62806927
74Neurofibrillary tangles (HP:0002185)1.62120340
75Natal tooth (HP:0000695)1.61791631
76Abnormality of the distal phalanges of the toes (HP:0010182)1.61308542
77Premature skin wrinkling (HP:0100678)1.60690194
78Joint laxity (HP:0001388)1.60586324
79Abnormality of skeletal muscle fiber size (HP:0012084)1.60397235
80Back pain (HP:0003418)1.60007900
81Abnormal ossification of hand bones (HP:0005921)1.59541856
82Slow saccadic eye movements (HP:0000514)1.58634233
83Termporal pattern (HP:0011008)1.55482947
84Insidious onset (HP:0003587)1.55482947
85Vertebral arch anomaly (HP:0008438)1.54203157
86Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.53824884
87Narrow palate (HP:0000189)1.53696824
88Relative macrocephaly (HP:0004482)1.52364648
89Mucopolysacchariduria (HP:0008155)1.51249883
90Urinary glycosaminoglycan excretion (HP:0003541)1.51249883
91Ankle contracture (HP:0006466)1.50778446
92Pointed chin (HP:0000307)1.50705290
93Renal duplication (HP:0000075)1.50302458
94Increased IgE level (HP:0003212)1.50278814
95Arnold-Chiari malformation (HP:0002308)1.48834571
96Abnormality of the acetabulum (HP:0003170)1.47009898
97Elbow flexion contracture (HP:0002987)1.46739643
98Thoracic kyphosis (HP:0002942)1.46008261
99Deep philtrum (HP:0002002)1.44009897
100Abnormality of carpal bone ossification (HP:0006257)1.43185540

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.66742399
2TRIB34.29894787
3SMG13.21901931
4PRPF4B3.07478363
5ICK3.00979568
6EEF2K2.95094860
7SIK12.73084571
8ERN12.54540998
9FGFR42.39607419
10RIPK12.24569416
11IRAK32.21365222
12PDGFRA2.02392578
13TTN1.90897605
14MAP3K131.59179544
15MAP3K101.53017973
16CAMK1D1.50107555
17BRD41.45806083
18MTOR1.42446744
19MAP3K141.40007474
20PKN21.38256131
21LATS21.37306071
22KSR21.30909442
23MAP2K31.27435209
24CDC42BPA1.22598809
25EPHB11.18702380
26MST1R1.17030513
27CAMK1G1.15729558
28SCYL21.13912119
29EPHA21.11421355
30MARK21.07833682
31RIPK41.07144443
32FGFR31.03269491
33TAOK20.96027765
34MAP3K10.92401693
35PRKD20.89991955
36SIK20.89844765
37PTK20.89750434
38PTK60.89442763
39MAP3K30.89401599
40PAK40.87713519
41TAOK10.86424228
42DDR20.84498569
43PDGFRB0.82843602
44RPS6KA20.81189098
45HIPK20.79754777
46ZAP700.79210154
47TYRO30.78052089
48NEK90.77962393
49CDK60.77476615
50MAP4K10.76958035
51CDK40.76316921
52RET0.75737873
53PAK20.75155631
54MAPK110.74433543
55RPS6KB20.71882760
56JAK10.70498927
57PDPK10.69282960
58CDK70.68816799
59JAK30.68739144
60TYK20.67442063
61TRPM70.67288203
62NME20.66277689
63SGK30.65365710
64NTRK10.65250537
65MAP3K80.63511843
66MAP3K70.62743607
67RPS6KL10.61512152
68RPS6KC10.61512152
69BMX0.60930038
70TBK10.60685392
71MET0.59692566
72CDK90.58363949
73MAP3K60.57965173
74WNK10.55557084
75SIK30.53308203
76PRKD30.53033559
77STK380.52951967
78MAP3K20.52828484
79MAP3K90.52205133
80AKT30.51598958
81CHUK0.50883756
82IRAK40.48962909
83CLK10.48732708
84MELK0.48478500
85IRAK20.47763105
86LATS10.47062575
87ARAF0.44866439
88MAP2K20.43232505
89MAPK70.41159652
90ALK0.39861185
91MAPK100.39815250
92PDK10.39060824
93MOS0.38890020
94CSK0.38381761
95RPS6KA60.37812667
96LRRK20.34950283
97CHEK10.33590096
98DMPK0.32255599
99STK100.32250724
100MAPK120.32226302

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.43065132
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.26374738
3Chronic myeloid leukemia_Homo sapiens_hsa052202.21245939
4Acute myeloid leukemia_Homo sapiens_hsa052212.06168249
5Non-small cell lung cancer_Homo sapiens_hsa052231.86097035
6Pancreatic cancer_Homo sapiens_hsa052121.71797917
7Bladder cancer_Homo sapiens_hsa052191.69777203
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.60634180
9Endometrial cancer_Homo sapiens_hsa052131.56504952
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.56144990
11Renal cell carcinoma_Homo sapiens_hsa052111.55931203
12Thyroid cancer_Homo sapiens_hsa052161.54962670
13B cell receptor signaling pathway_Homo sapiens_hsa046621.54596097
14VEGF signaling pathway_Homo sapiens_hsa043701.52240856
15Central carbon metabolism in cancer_Homo sapiens_hsa052301.51745183
16Notch signaling pathway_Homo sapiens_hsa043301.49266017
17Prion diseases_Homo sapiens_hsa050201.41722734
18Thyroid hormone signaling pathway_Homo sapiens_hsa049191.40939830
19Prostate cancer_Homo sapiens_hsa052151.34782866
20mTOR signaling pathway_Homo sapiens_hsa041501.32940345
21Focal adhesion_Homo sapiens_hsa045101.32761585
22Small cell lung cancer_Homo sapiens_hsa052221.32490469
23Neurotrophin signaling pathway_Homo sapiens_hsa047221.32273494
24ErbB signaling pathway_Homo sapiens_hsa040121.27468944
25MicroRNAs in cancer_Homo sapiens_hsa052061.26085402
26Hepatitis B_Homo sapiens_hsa051611.23570197
27Glioma_Homo sapiens_hsa052141.23549192
28Osteoclast differentiation_Homo sapiens_hsa043801.23019756
29Proteoglycans in cancer_Homo sapiens_hsa052051.21703789
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21469788
31Adherens junction_Homo sapiens_hsa045201.21333113
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18244559
33Amoebiasis_Homo sapiens_hsa051461.17078341
34TNF signaling pathway_Homo sapiens_hsa046681.15614200
35Prolactin signaling pathway_Homo sapiens_hsa049171.14755119
36Insulin signaling pathway_Homo sapiens_hsa049101.14634092
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13891567
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13739958
39Hepatitis C_Homo sapiens_hsa051601.12480005
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.11677700
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06150604
42Toxoplasmosis_Homo sapiens_hsa051451.05498239
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05040752
44Influenza A_Homo sapiens_hsa051641.04336036
45Estrogen signaling pathway_Homo sapiens_hsa049151.03072574
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.02920578
47Lysine degradation_Homo sapiens_hsa003101.01514478
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.00153755
49Apoptosis_Homo sapiens_hsa042101.00082177
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99052709
51GnRH signaling pathway_Homo sapiens_hsa049120.98622535
52Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97051283
53Colorectal cancer_Homo sapiens_hsa052100.96034661
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95113594
55Insulin resistance_Homo sapiens_hsa049310.94855891
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.93923381
57Choline metabolism in cancer_Homo sapiens_hsa052310.93898358
58T cell receptor signaling pathway_Homo sapiens_hsa046600.93168304
59Measles_Homo sapiens_hsa051620.93066421
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92227790
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.90289435
62ECM-receptor interaction_Homo sapiens_hsa045120.89668691
63Inositol phosphate metabolism_Homo sapiens_hsa005620.87991493
64Viral carcinogenesis_Homo sapiens_hsa052030.86924325
65HIF-1 signaling pathway_Homo sapiens_hsa040660.85288808
66Leishmaniasis_Homo sapiens_hsa051400.85166901
67Pentose phosphate pathway_Homo sapiens_hsa000300.84385952
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82134970
69AMPK signaling pathway_Homo sapiens_hsa041520.81310857
70Fructose and mannose metabolism_Homo sapiens_hsa000510.81074968
71Lysosome_Homo sapiens_hsa041420.80615876
72Shigellosis_Homo sapiens_hsa051310.77052112
73HTLV-I infection_Homo sapiens_hsa051660.76536809
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.76402690
75FoxO signaling pathway_Homo sapiens_hsa040680.72540762
76Herpes simplex infection_Homo sapiens_hsa051680.72163642
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71426246
78Endocytosis_Homo sapiens_hsa041440.70580669
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68788538
80Salmonella infection_Homo sapiens_hsa051320.67087980
81Type II diabetes mellitus_Homo sapiens_hsa049300.66343201
82Platelet activation_Homo sapiens_hsa046110.66015033
83Malaria_Homo sapiens_hsa051440.64070555
84Pathways in cancer_Homo sapiens_hsa052000.63465595
85Long-term potentiation_Homo sapiens_hsa047200.63435833
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.63092684
87Tuberculosis_Homo sapiens_hsa051520.62493896
88mRNA surveillance pathway_Homo sapiens_hsa030150.61860030
89Chemokine signaling pathway_Homo sapiens_hsa040620.55553625
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55146998
91MAPK signaling pathway_Homo sapiens_hsa040100.52865449
92Galactose metabolism_Homo sapiens_hsa000520.52096810
93Melanoma_Homo sapiens_hsa052180.51003702
94Pertussis_Homo sapiens_hsa051330.50860359
95Epstein-Barr virus infection_Homo sapiens_hsa051690.50585685
96Rap1 signaling pathway_Homo sapiens_hsa040150.48982092
97Fatty acid biosynthesis_Homo sapiens_hsa000610.48070126
98Complement and coagulation cascades_Homo sapiens_hsa046100.47605079
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47580682
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43607508

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