SUMO2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.68236819
2establishment of protein localization to mitochondrial membrane (GO:0090151)6.08661047
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.76501043
4ATP synthesis coupled proton transport (GO:0015986)5.76501043
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.71288029
6regulation of mitochondrial translation (GO:0070129)5.53168105
7respiratory electron transport chain (GO:0022904)5.35204818
8protein complex biogenesis (GO:0070271)5.34202094
9chaperone-mediated protein transport (GO:0072321)5.26548569
10electron transport chain (GO:0022900)5.22253940
11mitochondrial respiratory chain complex assembly (GO:0033108)4.96433697
12maturation of 5.8S rRNA (GO:0000460)4.87536091
13sequestering of actin monomers (GO:0042989)4.68335739
14protein neddylation (GO:0045116)4.52881672
15ribosomal small subunit assembly (GO:0000028)4.50311046
16negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 4.43037070
17DNA deamination (GO:0045006)4.41649357
18NADH dehydrogenase complex assembly (GO:0010257)4.38968914
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.38968914
20mitochondrial respiratory chain complex I assembly (GO:0032981)4.38968914
21cytochrome complex assembly (GO:0017004)4.36750252
22RNA localization (GO:0006403)4.19940995
23positive regulation of translational initiation (GO:0045948)4.16461046
24pseudouridine synthesis (GO:0001522)4.13175267
25regulation of activation of Janus kinase activity (GO:0010533)4.12105038
26spliceosomal complex assembly (GO:0000245)4.07317301
27transcription elongation from RNA polymerase III promoter (GO:0006385)4.04830831
28termination of RNA polymerase III transcription (GO:0006386)4.04830831
29rRNA modification (GO:0000154)4.03731097
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.03679770
31tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.97279416
32RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.97279416
33inner mitochondrial membrane organization (GO:0007007)3.95689882
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.94842379
35viral transcription (GO:0019083)3.86428308
36pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.83765648
37translational termination (GO:0006415)3.83748176
38SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.69002700
39positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.67393562
40cotranslational protein targeting to membrane (GO:0006613)3.66114034
41hydrogen ion transmembrane transport (GO:1902600)3.65679392
42protein targeting to ER (GO:0045047)3.60027031
43negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.58638982
44regulation of helicase activity (GO:0051095)3.54692033
45establishment of protein localization to endoplasmic reticulum (GO:0072599)3.48462537
46respiratory chain complex IV assembly (GO:0008535)3.48441121
47cytidine deamination (GO:0009972)3.47220307
48cytidine metabolic process (GO:0046087)3.47220307
49cytidine catabolic process (GO:0006216)3.47220307
50spliceosomal snRNP assembly (GO:0000387)3.41022345
51establishment of protein localization to mitochondrion (GO:0072655)3.38094736
52protein localization to endoplasmic reticulum (GO:0070972)3.37354686
53regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.34585381
54proton transport (GO:0015992)3.33527611
55translation (GO:0006412)3.32982805
56proteasome assembly (GO:0043248)3.32929416
57hydrogen transport (GO:0006818)3.26202534
58oxidative phosphorylation (GO:0006119)3.25847251
59protein localization to mitochondrion (GO:0070585)3.25366269
60ribosomal small subunit biogenesis (GO:0042274)3.21965714
61GTP biosynthetic process (GO:0006183)3.20320683
62DNA integration (GO:0015074)3.20057786
63protein targeting to mitochondrion (GO:0006626)3.18582321
64purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.17066206
65translational elongation (GO:0006414)3.16523181
66ATP biosynthetic process (GO:0006754)3.16038476
67chromatin remodeling at centromere (GO:0031055)3.13160314
68histone mRNA metabolic process (GO:0008334)3.13086463
69secretory granule organization (GO:0033363)3.12992699
70organelle disassembly (GO:1903008)3.12844766
71purine nucleoside triphosphate biosynthetic process (GO:0009145)3.11566777
72CENP-A containing nucleosome assembly (GO:0034080)3.10831570
73pyrimidine nucleotide catabolic process (GO:0006244)3.09006656
74cullin deneddylation (GO:0010388)3.07891666
75intracellular protein transmembrane import (GO:0044743)3.07314785
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.06881328
77translational initiation (GO:0006413)3.01510810
78platelet dense granule organization (GO:0060155)3.00978303
79water-soluble vitamin biosynthetic process (GO:0042364)2.97246418
80cellular protein complex disassembly (GO:0043624)2.91734195
81DNA damage response, detection of DNA damage (GO:0042769)2.89949119
82nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.89784883
83regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.89002713
84regulation of mitotic spindle checkpoint (GO:1903504)2.89002713
85pyrimidine ribonucleoside catabolic process (GO:0046133)2.83591748
86negative regulation of heart rate (GO:0010459)2.83083325
87pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.81430832
88protein deneddylation (GO:0000338)2.79599068
89rRNA methylation (GO:0031167)2.77783216
90maturation of SSU-rRNA (GO:0030490)2.77519184
91ribonucleoside triphosphate biosynthetic process (GO:0009201)2.76346307
92somatic diversification of immune receptors via somatic mutation (GO:0002566)2.75107446
93somatic hypermutation of immunoglobulin genes (GO:0016446)2.75107446
94regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.73719129
95protein peptidyl-prolyl isomerization (GO:0000413)2.72319694
96viral life cycle (GO:0019058)2.70534960
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.69810992
98mitochondrial transport (GO:0006839)2.67926718
99positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.65667507
100negative regulation of ligase activity (GO:0051352)2.64330750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.04808942
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.91577642
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.83642679
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.44000363
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.18242763
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.76732034
7ELK1_19687146_ChIP-ChIP_HELA_Human2.69178672
8CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.62948574
9IGF1R_20145208_ChIP-Seq_DFB_Human2.57167303
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52306783
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.46973694
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.39436605
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.35090775
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34302264
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.27957873
16VDR_23849224_ChIP-Seq_CD4+_Human2.27478022
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22097357
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21084100
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.18197112
20ZNF274_21170338_ChIP-Seq_K562_Hela2.15981409
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14633171
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09544183
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.07088959
24VDR_22108803_ChIP-Seq_LS180_Human2.01704622
25MYC_18940864_ChIP-ChIP_HL60_Human2.00246278
26EWS_26573619_Chip-Seq_HEK293_Human1.99208493
27FOXP3_21729870_ChIP-Seq_TREG_Human1.94551140
28TAF15_26573619_Chip-Seq_HEK293_Human1.93364146
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.87464715
30FUS_26573619_Chip-Seq_HEK293_Human1.87101271
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75098065
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71086059
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.67366352
34EZH2_22144423_ChIP-Seq_EOC_Human1.65802270
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60494793
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.59814192
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.59318246
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53631114
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51021338
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47293655
41P300_19829295_ChIP-Seq_ESCs_Human1.45645906
42TTF2_22483619_ChIP-Seq_HELA_Human1.42069807
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41052006
44SOX2_16153702_ChIP-ChIP_HESCs_Human1.40621460
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36302309
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35660632
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.35212537
48ER_23166858_ChIP-Seq_MCF-7_Human1.34538292
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.33245137
50FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.32538735
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32355375
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28922852
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28553828
54NANOG_16153702_ChIP-ChIP_HESCs_Human1.27768674
55RNF2_27304074_Chip-Seq_NSC_Mouse1.24610612
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21786483
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20413170
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19603737
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17752718
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17354368
61GBX2_23144817_ChIP-Seq_PC3_Human1.14273528
62XRN2_22483619_ChIP-Seq_HELA_Human1.14272612
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.14017284
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.12194151
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11721126
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11349018
67DCP1A_22483619_ChIP-Seq_HELA_Human1.11115853
68AR_20517297_ChIP-Seq_VCAP_Human1.10871959
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10527864
70CBP_20019798_ChIP-Seq_JUKART_Human1.08493005
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08493005
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06166791
73SOX2_19829295_ChIP-Seq_ESCs_Human1.05587772
74NANOG_19829295_ChIP-Seq_ESCs_Human1.05587772
75E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05429929
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03054750
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.03054750
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02645350
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.02180818
80GABP_19822575_ChIP-Seq_HepG2_Human1.01780114
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00626722
82EZH2_27294783_Chip-Seq_NPCs_Mouse0.98986665
83IRF1_19129219_ChIP-ChIP_H3396_Human0.97349595
84FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.96883357
85SALL1_21062744_ChIP-ChIP_HESCs_Human0.96713289
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95809868
87TP53_22573176_ChIP-Seq_HFKS_Human0.94809240
88TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94388409
89GATA1_26923725_Chip-Seq_HPCs_Mouse0.93510922
90MYC_19079543_ChIP-ChIP_MESCs_Mouse0.93279549
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93129629
92SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90629781
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90091294
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88613055
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86267845
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86267845
97HTT_18923047_ChIP-ChIP_STHdh_Human0.86133951
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85875708
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.82519841
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81785102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.93332092
2MP0009379_abnormal_foot_pigmentation3.23281087
3MP0006072_abnormal_retinal_apoptosis2.90651315
4MP0001529_abnormal_vocalization2.89946714
5MP0005084_abnormal_gallbladder_morpholo2.42840936
6MP0002277_abnormal_respiratory_mucosa2.15902672
7MP0002102_abnormal_ear_morphology2.07332530
8MP0004147_increased_porphyrin_level2.03413013
9MP0001188_hyperpigmentation1.99428475
10MP0004142_abnormal_muscle_tone1.93835916
11MP0000049_abnormal_middle_ear1.91344442
12MP0003693_abnormal_embryo_hatching1.91182263
13MP0002736_abnormal_nociception_after1.89559748
14MP0004145_abnormal_muscle_electrophysio1.88477859
15MP0008058_abnormal_DNA_repair1.85854200
16MP0005253_abnormal_eye_physiology1.76508993
17MP0001984_abnormal_olfaction1.76145283
18MP0001968_abnormal_touch/_nociception1.71430650
19MP0006035_abnormal_mitochondrial_morpho1.71379485
20MP0002234_abnormal_pharynx_morphology1.69379022
21MP0003646_muscle_fatigue1.69012286
22MP0001293_anophthalmia1.67712967
23MP0005645_abnormal_hypothalamus_physiol1.63328919
24MP0005671_abnormal_response_to1.62123201
25MP0003880_abnormal_central_pattern1.59469538
26MP0006276_abnormal_autonomic_nervous1.53047161
27MP0006036_abnormal_mitochondrial_physio1.52957098
28MP0003122_maternal_imprinting1.48695273
29MP0004957_abnormal_blastocyst_morpholog1.46779118
30MP0001486_abnormal_startle_reflex1.46430672
31MP0000631_abnormal_neuroendocrine_gland1.46048482
32MP0008995_early_reproductive_senescence1.44986595
33MP0008789_abnormal_olfactory_epithelium1.39213535
34MP0005551_abnormal_eye_electrophysiolog1.38524563
35MP0003011_delayed_dark_adaptation1.38170019
36MP0001919_abnormal_reproductive_system1.37979602
37MP0004133_heterotaxia1.36764864
38MP0001905_abnormal_dopamine_level1.36579527
39MP0008877_abnormal_DNA_methylation1.35301993
40MP0009745_abnormal_behavioral_response1.34681683
41MP0002272_abnormal_nervous_system1.33732714
42MP0003567_abnormal_fetal_cardiomyocyte1.33654267
43MP0003787_abnormal_imprinting1.32947252
44MP0002837_dystrophic_cardiac_calcinosis1.32372089
45MP0003938_abnormal_ear_development1.32324912
46MP0003941_abnormal_skin_development1.30227707
47MP0002938_white_spotting1.29587467
48MP0003121_genomic_imprinting1.28713100
49MP0003136_yellow_coat_color1.28457814
50MP0003718_maternal_effect1.28174718
51MP0003186_abnormal_redox_activity1.27294323
52MP0002822_catalepsy1.22239889
53MP0001485_abnormal_pinna_reflex1.20701883
54MP0008872_abnormal_physiological_respon1.19352984
55MP0002751_abnormal_autonomic_nervous1.16266188
56MP0005389_reproductive_system_phenotype1.15168386
57MP0005410_abnormal_fertilization1.13401063
58MP0001286_abnormal_eye_development1.10550958
59MP0005394_taste/olfaction_phenotype1.10407519
60MP0005499_abnormal_olfactory_system1.10407519
61MP0002735_abnormal_chemical_nociception1.09722346
62MP0002752_abnormal_somatic_nervous1.08670999
63MP0003195_calcinosis1.07397694
64MP0008932_abnormal_embryonic_tissue1.05768567
65MP0002233_abnormal_nose_morphology1.04907250
66MP0002734_abnormal_mechanical_nocicepti1.04526054
67MP0000372_irregular_coat_pigmentation1.03802134
68MP0009764_decreased_sensitivity_to0.99742409
69MP0009046_muscle_twitch0.98888103
70MP0003635_abnormal_synaptic_transmissio0.95214865
71MP0002653_abnormal_ependyma_morphology0.94993307
72MP0009697_abnormal_copulation0.94931016
73MP0002572_abnormal_emotion/affect_behav0.94535340
74MP0000026_abnormal_inner_ear0.93940906
75MP0004885_abnormal_endolymph0.92849067
76MP0001970_abnormal_pain_threshold0.92533015
77MP0008007_abnormal_cellular_replicative0.92531269
78MP0005377_hearing/vestibular/ear_phenot0.91950615
79MP0003878_abnormal_ear_physiology0.91950615
80MP0003137_abnormal_impulse_conducting0.91349579
81MP0010094_abnormal_chromosome_stability0.90651967
82MP0005075_abnormal_melanosome_morpholog0.89956906
83MP0008875_abnormal_xenobiotic_pharmacok0.89328332
84MP0005391_vision/eye_phenotype0.88282250
85MP0002638_abnormal_pupillary_reflex0.87991163
86MP0003077_abnormal_cell_cycle0.87000178
87MP0004742_abnormal_vestibular_system0.86044562
88MP0002184_abnormal_innervation0.85043009
89MP0005195_abnormal_posterior_eye0.84970931
90MP0002160_abnormal_reproductive_system0.84739222
91MP0001963_abnormal_hearing_physiology0.82640972
92MP0010386_abnormal_urinary_bladder0.81575180
93MP0004215_abnormal_myocardial_fiber0.81341017
94MP0002090_abnormal_vision0.80813260
95MP0002697_abnormal_eye_size0.79859345
96MP0002163_abnormal_gland_morphology0.79272176
97MP0001835_abnormal_antigen_presentation0.76849678
98MP0003937_abnormal_limbs/digits/tail_de0.75492148
99MP0000778_abnormal_nervous_system0.73120025
100MP0002282_abnormal_trachea_morphology0.72748647

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.44102001
2Aplastic anemia (HP:0001915)4.90074510
3Abnormal mitochondria in muscle tissue (HP:0008316)4.76350717
4Mitochondrial inheritance (HP:0001427)4.71368631
5Increased hepatocellular lipid droplets (HP:0006565)4.65486741
6Acute encephalopathy (HP:0006846)4.54303843
7Progressive macrocephaly (HP:0004481)4.52218568
8Lipid accumulation in hepatocytes (HP:0006561)4.35670116
9Increased CSF lactate (HP:0002490)4.02802103
10Hepatocellular necrosis (HP:0001404)3.97739866
11Oral leukoplakia (HP:0002745)3.81754680
12Renal Fanconi syndrome (HP:0001994)3.52179538
13Cerebral edema (HP:0002181)3.46769602
14Hepatic necrosis (HP:0002605)3.46341711
15Increased intramyocellular lipid droplets (HP:0012240)3.24140955
163-Methylglutaconic aciduria (HP:0003535)3.20182163
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.16484667
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.16484667
19Methylmalonic acidemia (HP:0002912)3.05599590
20Pancreatic cysts (HP:0001737)3.01992528
21True hermaphroditism (HP:0010459)2.97544888
22Septo-optic dysplasia (HP:0100842)2.97113987
23Exertional dyspnea (HP:0002875)2.89009136
24Pancreatic fibrosis (HP:0100732)2.83278568
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.78329291
26Colon cancer (HP:0003003)2.74056667
27Abnormal number of erythroid precursors (HP:0012131)2.69738801
28Increased muscle lipid content (HP:0009058)2.69638292
29Leukodystrophy (HP:0002415)2.68735639
30Macrocytic anemia (HP:0001972)2.65896560
31Congenital, generalized hypertrichosis (HP:0004540)2.57815683
32Molar tooth sign on MRI (HP:0002419)2.54418737
33Abnormality of midbrain morphology (HP:0002418)2.54418737
34Nephronophthisis (HP:0000090)2.53148768
35Optic disc pallor (HP:0000543)2.46892946
36Lactic acidosis (HP:0003128)2.43010776
37Respiratory failure (HP:0002878)2.42489937
38Abnormality of cells of the erythroid lineage (HP:0012130)2.37076079
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.35944017
40Increased serum lactate (HP:0002151)2.35383730
41Methylmalonic aciduria (HP:0012120)2.31473943
42Lethargy (HP:0001254)2.28966235
43Short tibia (HP:0005736)2.26904435
44Respiratory difficulties (HP:0002880)2.24556997
45Exercise intolerance (HP:0003546)2.23448463
46Abnormality of renal resorption (HP:0011038)2.22270296
47Cerebral hypomyelination (HP:0006808)2.21505525
48Sclerocornea (HP:0000647)2.19722162
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.14754993
50Medial flaring of the eyebrow (HP:0010747)2.13140168
51Type 2 muscle fiber atrophy (HP:0003554)2.08445056
52Absent septum pellucidum (HP:0001331)2.04910969
53CNS demyelination (HP:0007305)2.03611835
54Fibular aplasia (HP:0002990)2.03253987
55Growth hormone deficiency (HP:0000824)2.02555458
56Abnormality of the septum pellucidum (HP:0007375)2.02273275
57Pendular nystagmus (HP:0012043)2.00557206
58Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.94287652
59Gait imbalance (HP:0002141)1.94021882
60Abnormality of urine glucose concentration (HP:0011016)1.92646927
61Glycosuria (HP:0003076)1.92646927
62Abnormality of the renal medulla (HP:0100957)1.92023812
63Muscle fiber atrophy (HP:0100295)1.91618992
64Hyperglycinemia (HP:0002154)1.91188120
65Congenital primary aphakia (HP:0007707)1.89848502
66Constricted visual fields (HP:0001133)1.89784961
67Abnormal respiratory motile cilium physiology (HP:0012261)1.89419979
68Pallor (HP:0000980)1.89143812
69Concave nail (HP:0001598)1.88754259
70Abnormality of serum amino acid levels (HP:0003112)1.85347711
71Hyperphosphaturia (HP:0003109)1.83234044
72Carpal bone hypoplasia (HP:0001498)1.82067824
73Male pseudohermaphroditism (HP:0000037)1.79692035
74Abnormality of the vitamin B12 metabolism (HP:0004341)1.79084641
75Pancytopenia (HP:0001876)1.78567718
76Abnormality of homocysteine metabolism (HP:0010919)1.78085650
77Homocystinuria (HP:0002156)1.78085650
78Optic nerve hypoplasia (HP:0000609)1.77668323
79Aplasia/Hypoplasia of the tongue (HP:0010295)1.76636965
80Medulloblastoma (HP:0002885)1.75432549
81Anencephaly (HP:0002323)1.74812279
82Decreased central vision (HP:0007663)1.72766041
83Abolished electroretinogram (ERG) (HP:0000550)1.72398278
84Abnormality of vitamin B metabolism (HP:0004340)1.72029877
85Renal cortical cysts (HP:0000803)1.71562960
86Cellular immunodeficiency (HP:0005374)1.69192699
87Nephrogenic diabetes insipidus (HP:0009806)1.68998827
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68802929
89Abnormality of alanine metabolism (HP:0010916)1.68802929
90Hyperalaninemia (HP:0003348)1.68802929
91Generalized aminoaciduria (HP:0002909)1.68520538
92Abnormal ciliary motility (HP:0012262)1.68233474
93Supernumerary spleens (HP:0009799)1.67480801
94Megaloblastic anemia (HP:0001889)1.66153922
95Abnormal lung lobation (HP:0002101)1.65884961
96Abnormal respiratory motile cilium morphology (HP:0005938)1.65841420
97Abnormal respiratory epithelium morphology (HP:0012253)1.65841420
98Emotional lability (HP:0000712)1.64947966
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63198384
100Absent rod-and cone-mediated responses on ERG (HP:0007688)1.61863076

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.76932643
2VRK22.97263978
3RIPK12.87315729
4MAP3K42.65565252
5CDC72.56382281
6MAP2K72.48711033
7VRK12.46588006
8CDK192.37918212
9INSRR2.35674848
10SRPK12.34226244
11ZAK2.28253882
12WNK32.21364364
13BCR2.19160821
14DYRK22.16480015
15TXK1.91045416
16BMPR21.88441303
17MST41.84701322
18NME11.83154482
19TRIM281.74181407
20BUB11.73934556
21TLK11.70604637
22STK161.70501417
23NUAK11.61715125
24DYRK31.52176980
25ADRBK21.51504957
26TSSK61.50045767
27MAP3K121.43506009
28KDR1.43344561
29MAPK131.33123941
30BCKDK1.32132577
31NEK11.28792566
32PBK1.27227484
33OXSR11.18417750
34PLK31.17965505
35PRKCG1.15686912
36CSNK1G31.13849201
37PRKCI1.13229275
38CSNK1G11.11966418
39MKNK11.10912108
40GRK11.09244840
41CSNK1G21.04632939
42PRKCE0.96822894
43MAPK150.95829690
44CSNK1A1L0.95273194
45DAPK30.93111387
46TNIK0.92983567
47BMPR1B0.92654009
48PLK40.90021009
49UHMK10.88423910
50EIF2AK30.88147738
51TAF10.81282079
52MAP2K40.80086622
53PINK10.75229845
54RPS6KA50.74161144
55MKNK20.73877495
56MAP4K10.73849803
57PNCK0.73842189
58MARK10.72562680
59BLK0.72300355
60TIE10.71588733
61CASK0.68391074
62ERBB30.68100252
63AURKB0.64053022
64STK40.61885935
65CSNK2A10.60925804
66PLK10.59486138
67OBSCN0.58898258
68CSNK2A20.58004644
69PAK40.57555214
70EIF2AK20.57361849
71TAOK30.55157734
72RPS6KA40.53684540
73CAMKK20.53422267
74CSNK1A10.49712765
75PKN10.48390434
76CAMK2A0.47668915
77TAOK10.47196222
78GRK60.46325439
79GRK70.45306637
80PIM10.44657423
81STK38L0.44584710
82BRSK20.44455608
83CDK30.42439329
84NEK20.38917765
85PDK20.38714775
86DYRK1B0.38613259
87CHEK20.38323310
88MINK10.36225269
89PLK20.35587275
90FRK0.34169374
91PRKG10.33834087
92PRKACA0.33739132
93CDK80.33691690
94CAMK10.33277023
95ATR0.33263512
96WEE10.32732867
97WNK40.32296322
98MYLK0.31866462
99DAPK10.31118215
100SYK0.30330602

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.81603189
2Parkinsons disease_Homo sapiens_hsa050124.10691093
3Ribosome_Homo sapiens_hsa030104.09186367
4Protein export_Homo sapiens_hsa030603.59390607
5Proteasome_Homo sapiens_hsa030503.59052178
6RNA polymerase_Homo sapiens_hsa030202.99898892
7Huntingtons disease_Homo sapiens_hsa050162.94822331
8Alzheimers disease_Homo sapiens_hsa050102.62829095
9Cardiac muscle contraction_Homo sapiens_hsa042602.44824692
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.35815211
11Spliceosome_Homo sapiens_hsa030402.21374153
12Mismatch repair_Homo sapiens_hsa034302.03225636
13Graft-versus-host disease_Homo sapiens_hsa053321.97077876
14RNA degradation_Homo sapiens_hsa030181.88905199
15Asthma_Homo sapiens_hsa053101.84786860
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80302953
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75450237
18Autoimmune thyroid disease_Homo sapiens_hsa053201.63890720
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62587902
20Homologous recombination_Homo sapiens_hsa034401.60557943
21Allograft rejection_Homo sapiens_hsa053301.50345735
22Nicotine addiction_Homo sapiens_hsa050331.44008080
23DNA replication_Homo sapiens_hsa030301.43360574
24RNA transport_Homo sapiens_hsa030131.42380284
25Type I diabetes mellitus_Homo sapiens_hsa049401.36758728
26Antigen processing and presentation_Homo sapiens_hsa046121.29681149
27Basal transcription factors_Homo sapiens_hsa030221.26170606
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23949443
29Pyrimidine metabolism_Homo sapiens_hsa002401.23946170
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23384051
31Systemic lupus erythematosus_Homo sapiens_hsa053221.13473471
32Phototransduction_Homo sapiens_hsa047441.13171487
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.10519982
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05804219
35Nucleotide excision repair_Homo sapiens_hsa034201.05329675
36Purine metabolism_Homo sapiens_hsa002301.03725212
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01863061
38Propanoate metabolism_Homo sapiens_hsa006400.96166250
39Tyrosine metabolism_Homo sapiens_hsa003500.94067688
40Fanconi anemia pathway_Homo sapiens_hsa034600.92627944
41Rheumatoid arthritis_Homo sapiens_hsa053230.91787282
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90630525
43Olfactory transduction_Homo sapiens_hsa047400.81394462
44Butanoate metabolism_Homo sapiens_hsa006500.79965159
45Primary immunodeficiency_Homo sapiens_hsa053400.79666233
46Caffeine metabolism_Homo sapiens_hsa002320.77839973
47Glutathione metabolism_Homo sapiens_hsa004800.74977145
48Taste transduction_Homo sapiens_hsa047420.71889405
49Peroxisome_Homo sapiens_hsa041460.70318353
50Base excision repair_Homo sapiens_hsa034100.70117476
51Steroid biosynthesis_Homo sapiens_hsa001000.67349368
52Collecting duct acid secretion_Homo sapiens_hsa049660.66942967
53GABAergic synapse_Homo sapiens_hsa047270.65223055
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62685878
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62622663
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62387366
57Chemical carcinogenesis_Homo sapiens_hsa052040.62014207
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.61564276
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61542176
60Regulation of autophagy_Homo sapiens_hsa041400.60361045
61Morphine addiction_Homo sapiens_hsa050320.59089967
62Nitrogen metabolism_Homo sapiens_hsa009100.57874885
63Linoleic acid metabolism_Homo sapiens_hsa005910.57850137
64Non-homologous end-joining_Homo sapiens_hsa034500.57693309
65Epstein-Barr virus infection_Homo sapiens_hsa051690.56030758
66Tryptophan metabolism_Homo sapiens_hsa003800.55944688
67Metabolic pathways_Homo sapiens_hsa011000.55611591
68Pyruvate metabolism_Homo sapiens_hsa006200.55480217
69One carbon pool by folate_Homo sapiens_hsa006700.53964350
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49989601
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49947378
72mRNA surveillance pathway_Homo sapiens_hsa030150.48176741
73Alcoholism_Homo sapiens_hsa050340.46898970
74Folate biosynthesis_Homo sapiens_hsa007900.46622504
75Oocyte meiosis_Homo sapiens_hsa041140.46536252
76Sulfur relay system_Homo sapiens_hsa041220.45902769
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43708667
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43140857
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42507294
80Selenocompound metabolism_Homo sapiens_hsa004500.42119527
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40456687
82Retinol metabolism_Homo sapiens_hsa008300.40365296
83Viral myocarditis_Homo sapiens_hsa054160.37617405
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34257456
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33418716
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.32703449
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30248496
88beta-Alanine metabolism_Homo sapiens_hsa004100.30172987
89Hematopoietic cell lineage_Homo sapiens_hsa046400.29573604
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29293917
91Fatty acid degradation_Homo sapiens_hsa000710.26145097
92Staphylococcus aureus infection_Homo sapiens_hsa051500.26021264
93Vitamin digestion and absorption_Homo sapiens_hsa049770.25404080
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25380641
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23838727
96Fatty acid metabolism_Homo sapiens_hsa012120.23138877
97Arachidonic acid metabolism_Homo sapiens_hsa005900.20828389
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19639653
99Cell cycle_Homo sapiens_hsa041100.19573822
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17656147

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