SUMO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.85720642
2maturation of SSU-rRNA (GO:0030490)4.78865387
3DNA strand elongation involved in DNA replication (GO:0006271)4.44971211
4viral transcription (GO:0019083)4.35051136
5ribosomal small subunit biogenesis (GO:0042274)4.32894908
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.32077577
7telomere maintenance via semi-conservative replication (GO:0032201)4.31735860
8translational termination (GO:0006415)4.30219228
9DNA strand elongation (GO:0022616)4.24670889
10ATP synthesis coupled proton transport (GO:0015986)4.23226690
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.23226690
12CENP-A containing nucleosome assembly (GO:0034080)4.18580050
13DNA replication initiation (GO:0006270)4.14227384
14formation of translation preinitiation complex (GO:0001731)4.06095953
15purine nucleobase biosynthetic process (GO:0009113)4.04928863
16DNA replication checkpoint (GO:0000076)4.03484245
17chromatin remodeling at centromere (GO:0031055)4.03364715
18nucleobase biosynthetic process (GO:0046112)4.02434935
19telomere maintenance via recombination (GO:0000722)3.93482614
20ribosomal large subunit biogenesis (GO:0042273)3.91698414
21proteasome assembly (GO:0043248)3.91338143
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.88118037
23mitotic metaphase plate congression (GO:0007080)3.87522312
24translational elongation (GO:0006414)3.84569274
25DNA deamination (GO:0045006)3.84284730
26SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.83666448
27DNA replication-independent nucleosome assembly (GO:0006336)3.82150221
28DNA replication-independent nucleosome organization (GO:0034724)3.82150221
29spliceosomal snRNP assembly (GO:0000387)3.79917026
30translational initiation (GO:0006413)3.79460663
31mitotic recombination (GO:0006312)3.78618121
32cotranslational protein targeting to membrane (GO:0006613)3.78091898
33protein neddylation (GO:0045116)3.75544228
34ribonucleoprotein complex biogenesis (GO:0022613)3.75291530
35protein targeting to ER (GO:0045047)3.73159679
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.72847625
37anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.72557524
38establishment of integrated proviral latency (GO:0075713)3.71773057
39termination of RNA polymerase III transcription (GO:0006386)3.71208065
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.71208065
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.71046704
42DNA unwinding involved in DNA replication (GO:0006268)3.65371269
43viral mRNA export from host cell nucleus (GO:0046784)3.62568760
44cullin deneddylation (GO:0010388)3.62540945
45nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.60046560
467-methylguanosine mRNA capping (GO:0006370)3.59199659
47kinetochore organization (GO:0051383)3.58288371
487-methylguanosine RNA capping (GO:0009452)3.55732366
49RNA capping (GO:0036260)3.55732366
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.55699708
51transcription-coupled nucleotide-excision repair (GO:0006283)3.55315391
52chaperone-mediated protein transport (GO:0072321)3.55011791
53nucleotide-excision repair, DNA gap filling (GO:0006297)3.54194839
54establishment of protein localization to endoplasmic reticulum (GO:0072599)3.53831763
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.53798554
56protein localization to endoplasmic reticulum (GO:0070972)3.53339980
57DNA double-strand break processing (GO:0000729)3.51617100
58negative regulation of ligase activity (GO:0051352)3.50658729
59negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.50658729
60ribosome biogenesis (GO:0042254)3.49880759
61rRNA processing (GO:0006364)3.49811716
62cellular protein complex disassembly (GO:0043624)3.49752081
63telomere maintenance via telomere lengthening (GO:0010833)3.48959613
64DNA damage response, detection of DNA damage (GO:0042769)3.48029455
65spliceosomal complex assembly (GO:0000245)3.47283695
66attachment of spindle microtubules to kinetochore (GO:0008608)3.46757398
67ribosome assembly (GO:0042255)3.46263242
68viral life cycle (GO:0019058)3.43828831
69histone exchange (GO:0043486)3.41192778
70transcription elongation from RNA polymerase I promoter (GO:0006362)3.40828627
71protein deneddylation (GO:0000338)3.40766545
72kinetochore assembly (GO:0051382)3.39593264
73protein localization to kinetochore (GO:0034501)3.39025498
74rRNA metabolic process (GO:0016072)3.37843645
75termination of RNA polymerase I transcription (GO:0006363)3.36424939
76metaphase plate congression (GO:0051310)3.35882737
77establishment of viral latency (GO:0019043)3.32600871
78DNA replication-dependent nucleosome organization (GO:0034723)3.30781191
79DNA replication-dependent nucleosome assembly (GO:0006335)3.30781191
80translation (GO:0006412)3.29929653
81respiratory electron transport chain (GO:0022904)3.29016410
82rRNA modification (GO:0000154)3.25727274
83positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.24465851
84electron transport chain (GO:0022900)3.23193547
85G1/S transition of mitotic cell cycle (GO:0000082)3.22149606
86cell cycle G1/S phase transition (GO:0044843)3.22149606
87DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.20440064
88mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.20412215
89DNA ligation (GO:0006266)3.19492065
90regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.18245948
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.16454758
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.16454758
93protein complex disassembly (GO:0043241)3.15897783
94signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.14579978
95signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.14579978
96signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.14579978
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.13262827
98cellular component biogenesis (GO:0044085)3.12219498
99sequestering of actin monomers (GO:0042989)3.10863044
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.10180287
101regulation of mitotic spindle checkpoint (GO:1903504)3.10180287
102pseudouridine synthesis (GO:0001522)3.09070002
103signal transduction involved in DNA damage checkpoint (GO:0072422)3.09053821
104signal transduction involved in DNA integrity checkpoint (GO:0072401)3.09053821
105positive regulation of ligase activity (GO:0051351)3.08472680
106transcription from RNA polymerase I promoter (GO:0006360)3.07984915
107signal transduction involved in cell cycle checkpoint (GO:0072395)3.07326100
108regulation of mitochondrial translation (GO:0070129)3.06850045
109nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.06610338
110regulation of cellular amino acid metabolic process (GO:0006521)3.05547398
111spindle checkpoint (GO:0031577)3.04836016
112guanosine-containing compound biosynthetic process (GO:1901070)3.04494346
113DNA-templated transcription, termination (GO:0006353)3.03778967
114negative regulation of mitotic sister chromatid separation (GO:2000816)3.03751702
115negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03751702
116negative regulation of sister chromatid segregation (GO:0033046)3.03751702
117mitochondrial respiratory chain complex assembly (GO:0033108)3.00248796
118protein complex biogenesis (GO:0070271)2.94136692
119mitochondrial respiratory chain complex I assembly (GO:0032981)2.91291504
120NADH dehydrogenase complex assembly (GO:0010257)2.91291504
121mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91291504
122regulation of helicase activity (GO:0051095)2.89770250
123IMP biosynthetic process (GO:0006188)2.81522244
124respiratory chain complex IV assembly (GO:0008535)2.81377767
125DNA catabolic process, exonucleolytic (GO:0000738)2.79252470
126microtubule depolymerization (GO:0007019)2.78299330
127histone mRNA metabolic process (GO:0008334)2.76324982
128mitotic sister chromatid segregation (GO:0000070)2.72809205
129negative regulation of DNA-dependent DNA replication (GO:2000104)2.72254355
130negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.72153351
131negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.72153351
132mitotic spindle checkpoint (GO:0071174)2.72089197
133RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.71279618
134tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.71279618
135replication fork processing (GO:0031297)2.71174907
136negative regulation of chromosome segregation (GO:0051985)2.69040727
137protein localization to chromosome, centromeric region (GO:0071459)2.67405757
138ATP-dependent chromatin remodeling (GO:0043044)2.65030079
139regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.63816482
140protein targeting to mitochondrion (GO:0006626)2.62819959

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.60437370
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.60638871
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.15467225
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.77508302
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.75998732
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.75607897
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.57416519
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.39863634
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.31830629
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.31030108
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.21120676
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.15966837
13* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10869466
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.04660486
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.01019176
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.00204237
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.75979954
18* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.73365189
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.71110109
20VDR_23849224_ChIP-Seq_CD4+_Human2.63254088
21* XRN2_22483619_ChIP-Seq_HELA_Human2.54193704
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49426561
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.48815921
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47772542
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.40594142
26DCP1A_22483619_ChIP-Seq_HELA_Human2.31957362
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.26287909
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.24363906
29FOXP3_21729870_ChIP-Seq_TREG_Human2.20901767
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.19378156
31TTF2_22483619_ChIP-Seq_HELA_Human2.15898319
32ELK1_19687146_ChIP-ChIP_HELA_Human2.15863446
33THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13983295
34GABP_19822575_ChIP-Seq_HepG2_Human2.08103449
35ZNF274_21170338_ChIP-Seq_K562_Hela2.05005882
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04893011
37* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02500864
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.99707055
39EWS_26573619_Chip-Seq_HEK293_Human1.99189044
40AR_21909140_ChIP-Seq_LNCAP_Human1.94071216
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.88736561
42* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88578117
43FUS_26573619_Chip-Seq_HEK293_Human1.88215713
44* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87657893
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84989160
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80884231
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.79478186
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78861572
49* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.78638521
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71272706
51IGF1R_20145208_ChIP-Seq_DFB_Human1.70304009
52* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69457910
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.67072253
54VDR_22108803_ChIP-Seq_LS180_Human1.66831861
55* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64992471
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64251465
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.61330732
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59220455
59CIITA_25753668_ChIP-Seq_RAJI_Human1.55026367
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54628344
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54074699
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52776193
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50299885
64TAF15_26573619_Chip-Seq_HEK293_Human1.50069089
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.45904418
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41700714
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33379662
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33091155
69KDM5A_27292631_Chip-Seq_BREAST_Human1.30869519
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27476426
71MYC_18940864_ChIP-ChIP_HL60_Human1.24880951
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.22744401
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22657678
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20706282
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20594752
76* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18755226
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17108796
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16146864
79P300_19829295_ChIP-Seq_ESCs_Human1.15144193
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.12794602
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10547939
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09582362
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09124169
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06910642
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.05982261
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99778654
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98893918
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98804324
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98674140
90CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97636205
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96040251
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95163565
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94554609
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94136132
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92740965
96RNF2_27304074_Chip-Seq_NSC_Mouse0.91791166
97IRF1_19129219_ChIP-ChIP_H3396_Human0.91183036
98BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89987967
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.89885315
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89328463
101* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89096708
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88979556
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88921653
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88334464
105SALL1_21062744_ChIP-ChIP_HESCs_Human0.87977068
106POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86835043
107TFEB_21752829_ChIP-Seq_HELA_Human0.86381422
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85687045
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83864509
110SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82655951
111CBX2_27304074_Chip-Seq_ESCs_Mouse0.81945283
112TP53_22573176_ChIP-Seq_HFKS_Human0.80655731
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80360030
114PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80053061
115GBX2_23144817_ChIP-Seq_PC3_Human0.79711870
116EGR1_19374776_ChIP-ChIP_THP-1_Human0.79538602
117NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.78766541
118NANOG_21062744_ChIP-ChIP_HESCs_Human0.76929359
119HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76656352
120EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.76551428
121SOX2_16153702_ChIP-ChIP_HESCs_Human0.76359069
122SOX17_20123909_ChIP-Seq_XEN_Mouse0.76178551
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75660590
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75243770
125TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.73414464
126SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.73271549
127NANOG_16153702_ChIP-ChIP_HESCs_Human0.73215704
128FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72550314
129SPI1_23547873_ChIP-Seq_NB4_Human0.71047393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.35014248
2MP0010094_abnormal_chromosome_stability4.52200582
3MP0004957_abnormal_blastocyst_morpholog4.38101675
4MP0003111_abnormal_nucleus_morphology3.90411165
5MP0003077_abnormal_cell_cycle3.78964489
6MP0008057_abnormal_DNA_replication3.63922225
7MP0008058_abnormal_DNA_repair3.59212738
8MP0008007_abnormal_cellular_replicative2.86447139
9MP0003123_paternal_imprinting2.83182052
10MP0008932_abnormal_embryonic_tissue2.78174461
11MP0008877_abnormal_DNA_methylation2.52835255
12MP0009379_abnormal_foot_pigmentation2.42853969
13MP0003786_premature_aging2.30615638
14MP0006292_abnormal_olfactory_placode2.08861615
15MP0003880_abnormal_central_pattern2.04228724
16MP0001730_embryonic_growth_arrest1.93423829
17MP0002396_abnormal_hematopoietic_system1.92251279
18MP0000350_abnormal_cell_proliferation1.88695264
19MP0003121_genomic_imprinting1.85709419
20MP0003315_abnormal_perineum_morphology1.83755917
21MP0003718_maternal_effect1.80389878
22MP0002938_white_spotting1.70498566
23MP0000566_synostosis1.63156767
24MP0002102_abnormal_ear_morphology1.50979535
25MP0001697_abnormal_embryo_size1.48329351
26MP0008789_abnormal_olfactory_epithelium1.48119827
27MP0003567_abnormal_fetal_cardiomyocyte1.39151681
28MP0002233_abnormal_nose_morphology1.38288117
29MP0010030_abnormal_orbit_morphology1.38272090
30MP0001188_hyperpigmentation1.36762755
31MP0002210_abnormal_sex_determination1.33370289
32MP0002736_abnormal_nociception_after1.32787136
33MP0005187_abnormal_penis_morphology1.32581266
34MP0002080_prenatal_lethality1.32452396
35MP0001529_abnormal_vocalization1.32309989
36MP0001672_abnormal_embryogenesis/_devel1.31900361
37MP0005380_embryogenesis_phenotype1.31900361
38MP0002085_abnormal_embryonic_tissue1.29549458
39MP0000490_abnormal_crypts_of1.27978736
40MP0001984_abnormal_olfaction1.27579360
41MP0001293_anophthalmia1.26600713
42MP0002234_abnormal_pharynx_morphology1.26468559
43MP0000313_abnormal_cell_death1.26311284
44MP0002163_abnormal_gland_morphology1.23780266
45MP0005253_abnormal_eye_physiology1.22796649
46MP0000537_abnormal_urethra_morphology1.21746308
47MP0003890_abnormal_embryonic-extraembry1.21437117
48MP0005084_abnormal_gallbladder_morpholo1.19710229
49MP0000647_abnormal_sebaceous_gland1.18409521
50MP0004808_abnormal_hematopoietic_stem1.17304265
51MP0006276_abnormal_autonomic_nervous1.17297128
52MP0002697_abnormal_eye_size1.15721222
53MP0000778_abnormal_nervous_system1.14657673
54MP0001145_abnormal_male_reproductive1.14054430
55MP0002160_abnormal_reproductive_system1.12661231
56MP0009333_abnormal_splenocyte_physiolog1.12342814
57MP0002084_abnormal_developmental_patter1.11766096
58MP0003984_embryonic_growth_retardation1.10697253
59MP0002088_abnormal_embryonic_growth/wei1.07404377
60MP0002095_abnormal_skin_pigmentation1.06870277
61MP0000049_abnormal_middle_ear1.05699580
62MP0003941_abnormal_skin_development1.05492016
63MP0002751_abnormal_autonomic_nervous1.04307186
64MP0002019_abnormal_tumor_incidence1.02657474
65MP0002638_abnormal_pupillary_reflex1.02225202
66MP0001346_abnormal_lacrimal_gland0.99420827
67MP0000653_abnormal_sex_gland0.98391868
68MP0006072_abnormal_retinal_apoptosis0.98096954
69MP0002653_abnormal_ependyma_morphology0.98051331
70MP0003136_yellow_coat_color0.97705168
71MP0002132_abnormal_respiratory_system0.96498658
72MP0005391_vision/eye_phenotype0.96309088
73MP0005389_reproductive_system_phenotype0.95688211
74MP0005499_abnormal_olfactory_system0.95262119
75MP0005394_taste/olfaction_phenotype0.95262119
76MP0006054_spinal_hemorrhage0.94993279
77MP0001929_abnormal_gametogenesis0.94278916
78MP0003119_abnormal_digestive_system0.93112247
79MP0003938_abnormal_ear_development0.92887869
80MP0003755_abnormal_palate_morphology0.92218740
81MP0010307_abnormal_tumor_latency0.91959913
82MP0003937_abnormal_limbs/digits/tail_de0.91545793
83MP0005551_abnormal_eye_electrophysiolog0.90784053
84MP0003122_maternal_imprinting0.89883859
85MP0002184_abnormal_innervation0.89254699
86MP0004142_abnormal_muscle_tone0.89018040
87MP0001968_abnormal_touch/_nociception0.87494850
88MP0003763_abnormal_thymus_physiology0.86604241
89MP0004197_abnormal_fetal_growth/weight/0.86457373
90MP0002086_abnormal_extraembryonic_tissu0.86079220
91MP0001286_abnormal_eye_development0.84658617
92MP0000703_abnormal_thymus_morphology0.84419138
93MP0009672_abnormal_birth_weight0.83881047
94MP0002822_catalepsy0.83147870
95MP0002277_abnormal_respiratory_mucosa0.81461924
96MP0003698_abnormal_male_reproductive0.81284880
97MP0002752_abnormal_somatic_nervous0.81081160
98MP0009046_muscle_twitch0.80603354
99MP0006035_abnormal_mitochondrial_morpho0.80591555
100MP0002282_abnormal_trachea_morphology0.79845364
101MP0006036_abnormal_mitochondrial_physio0.78426186
102MP0001119_abnormal_female_reproductive0.77293139
103MP0003011_delayed_dark_adaptation0.75070703
104MP0002090_abnormal_vision0.74940152
105MP0000358_abnormal_cell_content/0.74796082
106MP0005195_abnormal_posterior_eye0.74549860
107MP0005423_abnormal_somatic_nervous0.74369590
108MP0001299_abnormal_eye_distance/0.74167066
109MP0008995_early_reproductive_senescence0.72538739
110MP0001324_abnormal_eye_pigmentation0.71546934
111MP0002557_abnormal_social/conspecific_i0.70939534
112MP0003221_abnormal_cardiomyocyte_apopto0.69615078
113MP0005397_hematopoietic_system_phenotyp0.68882147
114MP0001545_abnormal_hematopoietic_system0.68882147
115MP0002398_abnormal_bone_marrow0.68438721
116MP0005174_abnormal_tail_pigmentation0.67906013
117MP0001919_abnormal_reproductive_system0.67521398
118MP0000015_abnormal_ear_pigmentation0.67233715
119MP0009053_abnormal_anal_canal0.67201837
120MP0004133_heterotaxia0.66493847
121MP0003861_abnormal_nervous_system0.66381472
122MP0003787_abnormal_imprinting0.65369955
123MP0000631_abnormal_neuroendocrine_gland0.65350875
124MP0010352_gastrointestinal_tract_polyps0.64471642
125MP0001905_abnormal_dopamine_level0.63570550
126MP0002111_abnormal_tail_morphology0.62374816
127MP0003186_abnormal_redox_activity0.62319497
128MP0009697_abnormal_copulation0.61890980
129MP0005075_abnormal_melanosome_morpholog0.61081753
130MP0002722_abnormal_immune_system0.60120480
131MP0001485_abnormal_pinna_reflex0.59427257
132MP0001727_abnormal_embryo_implantation0.58513736
133MP0000372_irregular_coat_pigmentation0.58476716
134MP0002114_abnormal_axial_skeleton0.57105247
135MP0005384_cellular_phenotype0.56724695

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.14965090
2Abnormality of cells of the erythroid lineage (HP:0012130)4.89527425
3Reticulocytopenia (HP:0001896)4.70772157
4Abnormal number of erythroid precursors (HP:0012131)4.56947287
5Breast hypoplasia (HP:0003187)3.81755646
6Colon cancer (HP:0003003)3.42539059
7Patellar aplasia (HP:0006443)3.34252399
8Macrocytic anemia (HP:0001972)3.22932287
9Aplasia/Hypoplasia of the patella (HP:0006498)3.16902775
10Oral leukoplakia (HP:0002745)3.16248874
11Aplastic anemia (HP:0001915)3.15927471
12Pallor (HP:0000980)3.03523169
13Acute necrotizing encephalopathy (HP:0006965)2.90308481
14Chromsome breakage (HP:0040012)2.90123619
15Rough bone trabeculation (HP:0100670)2.83735811
16Abnormality of the anterior horn cell (HP:0006802)2.79480700
17Degeneration of anterior horn cells (HP:0002398)2.79480700
18Abnormality of the preputium (HP:0100587)2.79311147
19Meckel diverticulum (HP:0002245)2.77557324
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.76601427
2111 pairs of ribs (HP:0000878)2.73574930
22Cerebral hypomyelination (HP:0006808)2.68753766
23Abnormality of the ileum (HP:0001549)2.65811099
24Microretrognathia (HP:0000308)2.63329302
25Carpal bone hypoplasia (HP:0001498)2.62705195
26Mitochondrial inheritance (HP:0001427)2.60140805
27Abnormal mitochondria in muscle tissue (HP:0008316)2.58703229
28Selective tooth agenesis (HP:0001592)2.54202700
29Absent thumb (HP:0009777)2.52836063
30Abnormal lung lobation (HP:0002101)2.52625324
31Cerebral edema (HP:0002181)2.52224153
32Abnormality of chromosome stability (HP:0003220)2.49186438
33True hermaphroditism (HP:0010459)2.48549323
34Medulloblastoma (HP:0002885)2.42815778
35Increased CSF lactate (HP:0002490)2.42447514
36Premature graying of hair (HP:0002216)2.41814143
37Septo-optic dysplasia (HP:0100842)2.41202156
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.40125654
39Methylmalonic acidemia (HP:0002912)2.39167885
40Absent radius (HP:0003974)2.38796569
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37146944
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37146944
43Hyperglycinemia (HP:0002154)2.33554940
44Horseshoe kidney (HP:0000085)2.32465578
45Increased hepatocellular lipid droplets (HP:0006565)2.31575823
46Duodenal stenosis (HP:0100867)2.31421632
47Small intestinal stenosis (HP:0012848)2.31421632
48Renal Fanconi syndrome (HP:0001994)2.30814818
49Hepatic necrosis (HP:0002605)2.30531223
503-Methylglutaconic aciduria (HP:0003535)2.28037043
51Facial cleft (HP:0002006)2.27833423
52Abnormality of the labia minora (HP:0012880)2.27336063
53Progressive macrocephaly (HP:0004481)2.26955275
54Medial flaring of the eyebrow (HP:0010747)2.26724938
55Type I transferrin isoform profile (HP:0003642)2.26129785
56Aplasia involving forearm bones (HP:0009822)2.23472799
57Absent forearm bone (HP:0003953)2.23472799
58Cleft eyelid (HP:0000625)2.22725802
59Supernumerary spleens (HP:0009799)2.22115795
60Molar tooth sign on MRI (HP:0002419)2.21242646
61Abnormality of midbrain morphology (HP:0002418)2.21242646
62Increased serum pyruvate (HP:0003542)2.20962057
63Abnormality of glycolysis (HP:0004366)2.20962057
64Hepatocellular necrosis (HP:0001404)2.20714362
65Atresia of the external auditory canal (HP:0000413)2.18774457
66Abnormal number of incisors (HP:0011064)2.18734270
67Triphalangeal thumb (HP:0001199)2.18269812
68Myelodysplasia (HP:0002863)2.17036295
69Congenital primary aphakia (HP:0007707)2.16875462
70Cortical dysplasia (HP:0002539)2.15189060
71Neoplasm of the pancreas (HP:0002894)2.14540824
72Impulsivity (HP:0100710)2.14335090
73Increased serum lactate (HP:0002151)2.14048495
74Gait imbalance (HP:0002141)2.13921199
75Bone marrow hypocellularity (HP:0005528)2.11627207
76Stenosis of the external auditory canal (HP:0000402)2.11466252
77Glossoptosis (HP:0000162)2.10713879
78Cellular immunodeficiency (HP:0005374)2.10201937
79Pancreatic fibrosis (HP:0100732)2.07478203
80Abnormal trabecular bone morphology (HP:0100671)2.04214132
81Abnormality of methionine metabolism (HP:0010901)2.03254632
82Volvulus (HP:0002580)2.01725567
83Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01503690
84Anophthalmia (HP:0000528)2.01486761
85Vaginal atresia (HP:0000148)1.99951454
86Pancreatic cysts (HP:0001737)1.99869117
87Genital tract atresia (HP:0001827)1.99716451
88Intestinal atresia (HP:0011100)1.97153084
89Leukodystrophy (HP:0002415)1.97039609
90Optic disc pallor (HP:0000543)1.96554190
91Bilateral microphthalmos (HP:0007633)1.96529765
92Nephrogenic diabetes insipidus (HP:0009806)1.95549931
93Acute encephalopathy (HP:0006846)1.95175913
94Microvesicular hepatic steatosis (HP:0001414)1.94546459
95Abnormality of the duodenum (HP:0002246)1.93369476
96Lactic acidosis (HP:0003128)1.93133969
97Aplasia/Hypoplasia of the sternum (HP:0006714)1.91586794
98Abnormality of serum amino acid levels (HP:0003112)1.91190752
99Optic nerve coloboma (HP:0000588)1.90906412
100Agnosia (HP:0010524)1.90779152
101Type 2 muscle fiber atrophy (HP:0003554)1.90555131
102Muscle fiber atrophy (HP:0100295)1.90117074
103Sclerocornea (HP:0000647)1.89941181
104Trismus (HP:0000211)1.89740076
105Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.89530804
106Nephroblastoma (Wilms tumor) (HP:0002667)1.89335183
107Nephronophthisis (HP:0000090)1.88825281
108Congenital, generalized hypertrichosis (HP:0004540)1.87849566
109Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86980448
110Respiratory difficulties (HP:0002880)1.86609385
111Sloping forehead (HP:0000340)1.85292010
112Abnormality of alanine metabolism (HP:0010916)1.85047642
113Hyperalaninemia (HP:0003348)1.85047642
114Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85047642
115Depressed nasal ridge (HP:0000457)1.84510436
116Embryonal renal neoplasm (HP:0011794)1.83600467
117Preaxial hand polydactyly (HP:0001177)1.83528123
118Absent septum pellucidum (HP:0001331)1.83378829
119Lipid accumulation in hepatocytes (HP:0006561)1.82933441
120Methylmalonic aciduria (HP:0012120)1.82596533
121Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81880509
122Tracheoesophageal fistula (HP:0002575)1.79730470
123Multiple enchondromatosis (HP:0005701)1.79723753
124Esophageal atresia (HP:0002032)1.79681376
125Short thumb (HP:0009778)1.78491033
126Secondary amenorrhea (HP:0000869)1.77317871
127Hypoplasia of the radius (HP:0002984)1.76732234
128Pancytopenia (HP:0001876)1.75560411
129Bifid tongue (HP:0010297)1.75422208
130Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74991453
131Optic nerve hypoplasia (HP:0000609)1.74752616
132Gastrointestinal atresia (HP:0002589)1.74091078
133Exertional dyspnea (HP:0002875)1.73715227
134Atrophy/Degeneration involving motor neurons (HP:0007373)1.73699870
135Abnormality of aspartate family amino acid metabolism (HP:0010899)1.73113993
136Anencephaly (HP:0002323)1.71079398
137Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70632171
138Aplasia/Hypoplasia of the tongue (HP:0010295)1.69302727
139Megaloblastic anemia (HP:0001889)1.69269105
140Respiratory failure (HP:0002878)1.68973536
141Abnormality of the septum pellucidum (HP:0007375)1.67456423
142Abnormality of glycine metabolism (HP:0010895)1.67082849
143Abnormality of serine family amino acid metabolism (HP:0010894)1.67082849
144Abnormality of the carotid arteries (HP:0005344)1.66558782
145Exercise intolerance (HP:0003546)1.66349675
146Hyperglycinuria (HP:0003108)1.64940259

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.04118776
2WEE14.60013536
3CDC73.58866311
4STK163.50520276
5SRPK13.24819315
6EIF2AK13.21517394
7VRK23.01774927
8TRIM282.59360020
9BRSK22.58364829
10ACVR1B2.56112771
11NME22.54031770
12VRK12.52353217
13MKNK12.43564837
14TSSK62.40284558
15EIF2AK32.34312177
16CCNB12.21750192
17DYRK32.10884885
18NEK22.08031151
19PLK42.04656382
20PLK31.92469028
21NEK11.91921395
22PLK11.86532444
23MKNK21.83507595
24BRSK11.74538305
25PASK1.71815704
26MAP3K41.62502100
27NME11.57234061
28AURKB1.55057026
29CDK81.49971069
30TAF11.43480811
31TTK1.39376718
32MAP4K21.38888844
33MAP2K71.36404914
34ATR1.34998330
35TGFBR11.34727153
36CDK71.31875103
37TESK21.28268470
38TLK11.26639710
39RPS6KA41.22224538
40AURKA1.14987709
41CHEK21.14323647
42DYRK21.08850490
43MARK11.08420436
44RPS6KB21.05827352
45INSRR0.95284490
46PNCK0.94459995
47EIF2AK20.91190003
48BRAF0.90943907
49PIM20.89684772
50CHEK10.88436382
51ERBB30.83237477
52BCKDK0.82562630
53PAK40.80238820
54CSNK2A10.80236481
55MINK10.78341153
56MAP3K120.78205054
57ZAK0.77982738
58PBK0.77092750
59MST40.75901449
60GRK10.75121865
61CSNK2A20.74357476
62ADRBK20.72079064
63BCR0.68514716
64PRKCG0.67354730
65CDK40.66678810
66LIMK10.66263135
67CSNK1G30.64791329
68ATM0.63779645
69DAPK10.63579396
70RPS6KA50.62248969
71EPHA40.61552904
72FGFR10.60417227
73STK38L0.60344629
74CDK20.59305303
75ILK0.58970590
76AKT30.57404945
77MAP3K80.57012192
78MAPK130.56181021
79PRKCI0.55534297
80SCYL20.54974200
81PAK10.54659556
82YES10.54567316
83TESK10.53621826
84CDK190.53334575
85CDK10.52869845
86PINK10.52537630
87KDR0.52260557
88PLK20.47706734
89OXSR10.45864161
90MELK0.44606058
91BMPR1B0.43520218
92CDK30.43143140
93ARAF0.41391676
94WNK30.40968274
95ERBB40.40493826
96PRKCE0.39970003
97STK40.39012539
98CAMKK20.38485928
99CLK10.37703701
100STK390.36702553
101EPHA20.36275022
102UHMK10.36048234
103CSNK1G10.35736725
104PIM10.34383768
105STK30.34337110
106EPHB20.34027178
107TEC0.33807694
108NTRK20.33383616
109WNK40.33337599
110LRRK20.31039376
111CSNK1A10.30473828
112SIK30.30434463
113ALK0.29868165
114CSNK1A1L0.28273108
115CDK11A0.25684581
116CDK180.25677777
117CDK140.25194930
118CASK0.24454228
119DYRK1A0.22387669
120CDK150.21921512
121NUAK10.21654831
122CSNK1E0.21356196
123TAOK20.20880341
124TNIK0.19402890
125PRKDC0.18973963
126CSNK1G20.18830945
127MYLK0.18639696

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.58406000
2Ribosome_Homo sapiens_hsa030104.28263905
3Proteasome_Homo sapiens_hsa030504.18496238
4Mismatch repair_Homo sapiens_hsa034303.99546039
5RNA polymerase_Homo sapiens_hsa030203.97168883
6Spliceosome_Homo sapiens_hsa030403.53000513
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.47738061
8Nucleotide excision repair_Homo sapiens_hsa034202.97721031
9* RNA transport_Homo sapiens_hsa030132.91563460
10Homologous recombination_Homo sapiens_hsa034402.89841303
11Base excision repair_Homo sapiens_hsa034102.88383430
12Pyrimidine metabolism_Homo sapiens_hsa002402.71286282
13Cell cycle_Homo sapiens_hsa041102.50625491
14Basal transcription factors_Homo sapiens_hsa030222.17301728
15Fanconi anemia pathway_Homo sapiens_hsa034602.03309817
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.96320556
17RNA degradation_Homo sapiens_hsa030181.95690126
18Non-homologous end-joining_Homo sapiens_hsa034501.94905410
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84922075
20Protein export_Homo sapiens_hsa030601.84046977
21Parkinsons disease_Homo sapiens_hsa050121.70579293
22Oxidative phosphorylation_Homo sapiens_hsa001901.66985598
23Purine metabolism_Homo sapiens_hsa002301.62535947
24mRNA surveillance pathway_Homo sapiens_hsa030151.60787159
25Propanoate metabolism_Homo sapiens_hsa006401.55876097
26Steroid biosynthesis_Homo sapiens_hsa001001.52189407
27Huntingtons disease_Homo sapiens_hsa050161.51415004
28One carbon pool by folate_Homo sapiens_hsa006701.51025924
29p53 signaling pathway_Homo sapiens_hsa041151.33240760
30Pyruvate metabolism_Homo sapiens_hsa006201.28339548
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26111050
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21017831
33Epstein-Barr virus infection_Homo sapiens_hsa051691.20015351
34Fatty acid elongation_Homo sapiens_hsa000621.14354333
35Oocyte meiosis_Homo sapiens_hsa041141.08888930
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07294648
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06454622
38Butanoate metabolism_Homo sapiens_hsa006501.01021383
39Alzheimers disease_Homo sapiens_hsa050100.98576401
40Systemic lupus erythematosus_Homo sapiens_hsa053220.97126098
41Nicotine addiction_Homo sapiens_hsa050330.94014159
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92948666
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80887371
44Vitamin B6 metabolism_Homo sapiens_hsa007500.77071818
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75765277
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72375981
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72157164
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70084442
49Herpes simplex infection_Homo sapiens_hsa051680.66874695
50Carbon metabolism_Homo sapiens_hsa012000.66528902
51Viral carcinogenesis_Homo sapiens_hsa052030.64338648
52Antigen processing and presentation_Homo sapiens_hsa046120.64154203
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63111701
54Alcoholism_Homo sapiens_hsa050340.62590038
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62464271
56Peroxisome_Homo sapiens_hsa041460.62315147
57Folate biosynthesis_Homo sapiens_hsa007900.58664491
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.57922225
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57656133
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56716488
61HTLV-I infection_Homo sapiens_hsa051660.53181549
62Regulation of autophagy_Homo sapiens_hsa041400.52659037
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52337990
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52214623
65N-Glycan biosynthesis_Homo sapiens_hsa005100.50799267
66Collecting duct acid secretion_Homo sapiens_hsa049660.44651477
67Nitrogen metabolism_Homo sapiens_hsa009100.44397954
68Sulfur metabolism_Homo sapiens_hsa009200.44077531
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43151248
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.42961669
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42834155
72Thyroid cancer_Homo sapiens_hsa052160.42631154
73Tryptophan metabolism_Homo sapiens_hsa003800.41948466
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40607116
75Primary immunodeficiency_Homo sapiens_hsa053400.39301326
76beta-Alanine metabolism_Homo sapiens_hsa004100.38135605
77Arginine and proline metabolism_Homo sapiens_hsa003300.37199045
78Taste transduction_Homo sapiens_hsa047420.36701284
79Fatty acid metabolism_Homo sapiens_hsa012120.36587182
80Vitamin digestion and absorption_Homo sapiens_hsa049770.36482222
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35559805
82Legionellosis_Homo sapiens_hsa051340.35226423
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34781823
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34729264
85Colorectal cancer_Homo sapiens_hsa052100.34274984
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.32915492
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31199323
88Sulfur relay system_Homo sapiens_hsa041220.30153957
89Cardiac muscle contraction_Homo sapiens_hsa042600.30091158
90Glutathione metabolism_Homo sapiens_hsa004800.29938806
91Pentose phosphate pathway_Homo sapiens_hsa000300.29448139
92Olfactory transduction_Homo sapiens_hsa047400.29176113
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28297982
94GABAergic synapse_Homo sapiens_hsa047270.28288937
95Autoimmune thyroid disease_Homo sapiens_hsa053200.28183990
96Metabolic pathways_Homo sapiens_hsa011000.26976899
97Hippo signaling pathway_Homo sapiens_hsa043900.25796370
98MicroRNAs in cancer_Homo sapiens_hsa052060.25406323
99Chemical carcinogenesis_Homo sapiens_hsa052040.25005806
100Basal cell carcinoma_Homo sapiens_hsa052170.24223340
101Allograft rejection_Homo sapiens_hsa053300.24090845
102TGF-beta signaling pathway_Homo sapiens_hsa043500.23917592
103Hedgehog signaling pathway_Homo sapiens_hsa043400.23343150
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21735414
105Small cell lung cancer_Homo sapiens_hsa052220.21556093
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.20959612
107Asthma_Homo sapiens_hsa053100.20931855
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20913973
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.20818715
110Tyrosine metabolism_Homo sapiens_hsa003500.19618753
111Retinol metabolism_Homo sapiens_hsa008300.19551098
112Phototransduction_Homo sapiens_hsa047440.19197695
113Fatty acid degradation_Homo sapiens_hsa000710.19152010
114Hepatitis B_Homo sapiens_hsa051610.19005459
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18933936
116Fat digestion and absorption_Homo sapiens_hsa049750.18861817
117Shigellosis_Homo sapiens_hsa051310.17823380
118Linoleic acid metabolism_Homo sapiens_hsa005910.17239595
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16377732
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16002413
121Biosynthesis of amino acids_Homo sapiens_hsa012300.15927473
122Arachidonic acid metabolism_Homo sapiens_hsa005900.15004243
123Pathways in cancer_Homo sapiens_hsa052000.14588137
124Wnt signaling pathway_Homo sapiens_hsa043100.13688474
125Apoptosis_Homo sapiens_hsa042100.12945355
126Vibrio cholerae infection_Homo sapiens_hsa051100.12488041
127Type I diabetes mellitus_Homo sapiens_hsa049400.11645504
128Hematopoietic cell lineage_Homo sapiens_hsa046400.11306394
129Measles_Homo sapiens_hsa051620.10984896
130Graft-versus-host disease_Homo sapiens_hsa053320.06495130
131Viral myocarditis_Homo sapiens_hsa054160.06437903
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.05805728
133Selenocompound metabolism_Homo sapiens_hsa004500.03177085
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.02648830
135NOD-like receptor signaling pathway_Homo sapiens_hsa046210.01593202
136Renin-angiotensin system_Homo sapiens_hsa046140.01077428
137Fructose and mannose metabolism_Homo sapiens_hsa000510.01061830
138HIF-1 signaling pathway_Homo sapiens_hsa040660.01061475
139Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650-0.0101626
140PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0044163

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