SUMO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.06268778
2cullin deneddylation (GO:0010388)4.65092759
3negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.59410387
4protein deneddylation (GO:0000338)4.47010646
57-methylguanosine mRNA capping (GO:0006370)4.41118861
6positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.40582969
7RNA capping (GO:0036260)4.36788561
87-methylguanosine RNA capping (GO:0009452)4.36788561
9DNA double-strand break processing (GO:0000729)4.35109348
10regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.33358534
11anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.26893866
12ribosomal small subunit assembly (GO:0000028)4.26525501
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.24171826
14protein neddylation (GO:0045116)4.22618888
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.17339346
16termination of RNA polymerase III transcription (GO:0006386)4.15912790
17transcription elongation from RNA polymerase III promoter (GO:0006385)4.15912790
18negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.15190250
19negative regulation of ligase activity (GO:0051352)4.15190250
20histone exchange (GO:0043486)4.13360421
21regulation of cellular amino acid metabolic process (GO:0006521)4.03278025
22maturation of SSU-rRNA (GO:0030490)3.99800338
23purine nucleobase biosynthetic process (GO:0009113)3.99213001
24DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.97846916
25DNA deamination (GO:0045006)3.96712490
26signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.90643163
27intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.90643163
28signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.89600642
29signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.89600642
30signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.89600642
31ATP synthesis coupled proton transport (GO:0015986)3.88931178
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.88931178
33positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.85525500
34formation of translation preinitiation complex (GO:0001731)3.85238396
35transcription elongation from RNA polymerase I promoter (GO:0006362)3.84319053
36signal transduction involved in DNA damage checkpoint (GO:0072422)3.79986962
37signal transduction involved in DNA integrity checkpoint (GO:0072401)3.79986962
38ribosomal small subunit biogenesis (GO:0042274)3.79019371
39DNA damage response, detection of DNA damage (GO:0042769)3.77704062
40signal transduction involved in cell cycle checkpoint (GO:0072395)3.75453276
41DNA replication-independent nucleosome organization (GO:0034724)3.75333748
42DNA replication-independent nucleosome assembly (GO:0006336)3.75333748
43termination of RNA polymerase I transcription (GO:0006363)3.71791937
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.69314471
45rRNA modification (GO:0000154)3.68506441
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.67037497
47nucleobase biosynthetic process (GO:0046112)3.67021791
48positive regulation of ligase activity (GO:0051351)3.65792316
49CENP-A containing nucleosome assembly (GO:0034080)3.64095070
50DNA replication checkpoint (GO:0000076)3.63197059
51ribosomal large subunit biogenesis (GO:0042273)3.62977344
52mitotic metaphase plate congression (GO:0007080)3.60200390
53regulation of mitotic spindle checkpoint (GO:1903504)3.59050870
54regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.59050870
55ribonucleoprotein complex biogenesis (GO:0022613)3.55167678
56transcription from RNA polymerase I promoter (GO:0006360)3.54532624
57transcription-coupled nucleotide-excision repair (GO:0006283)3.52028126
58chaperone-mediated protein transport (GO:0072321)3.51581646
59respiratory chain complex IV assembly (GO:0008535)3.51385230
60chromatin remodeling at centromere (GO:0031055)3.45782281
61spliceosomal snRNP assembly (GO:0000387)3.44756752
62antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.44684900
63establishment of viral latency (GO:0019043)3.44197544
64ribosome biogenesis (GO:0042254)3.44158297
65respiratory electron transport chain (GO:0022904)3.42999245
66regulation of ubiquitin-protein transferase activity (GO:0051438)3.38086779
67negative regulation of DNA-dependent DNA replication (GO:2000104)3.36859649
68regulation of mitochondrial translation (GO:0070129)3.35767390
69electron transport chain (GO:0022900)3.35744888
70DNA catabolic process, exonucleolytic (GO:0000738)3.35688365
71maturation of 5.8S rRNA (GO:0000460)3.33248187
72rRNA processing (GO:0006364)3.33226834
73DNA replication-dependent nucleosome organization (GO:0034723)3.32106575
74DNA replication-dependent nucleosome assembly (GO:0006335)3.32106575
75histone mRNA metabolic process (GO:0008334)3.31797029
76translational termination (GO:0006415)3.31491383
77DNA ligation (GO:0006266)3.30715444
78protein complex biogenesis (GO:0070271)3.30118542
79regulation of helicase activity (GO:0051095)3.29965246
80guanosine-containing compound biosynthetic process (GO:1901070)3.29790445
81viral transcription (GO:0019083)3.28442504
82mitochondrial respiratory chain complex I assembly (GO:0032981)3.27269644
83NADH dehydrogenase complex assembly (GO:0010257)3.27269644
84mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.27269644
85cellular component biogenesis (GO:0044085)3.27231353
86transcription initiation from RNA polymerase I promoter (GO:0006361)3.26080184
87G1/S transition of mitotic cell cycle (GO:0000082)3.25284041
88cell cycle G1/S phase transition (GO:0044843)3.25284041
89DNA replication initiation (GO:0006270)3.25201864
90telomere maintenance via semi-conservative replication (GO:0032201)3.24823853
91DNA strand elongation involved in DNA replication (GO:0006271)3.24432926
92spliceosomal complex assembly (GO:0000245)3.24160513
93transcription elongation from RNA polymerase II promoter (GO:0006368)3.23925503
94regulation of ligase activity (GO:0051340)3.23569865
95ribosome assembly (GO:0042255)3.23232246
96protein localization to kinetochore (GO:0034501)3.22428342
97kinetochore assembly (GO:0051382)3.22224958
98translation (GO:0006412)3.22020468
99RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.21749181
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.21749181
101IMP biosynthetic process (GO:0006188)3.21104486
102viral mRNA export from host cell nucleus (GO:0046784)3.21078736
103mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.20980869
104L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.20737729
105rRNA metabolic process (GO:0016072)3.20557771
106protein targeting to mitochondrion (GO:0006626)3.20317046
107establishment of integrated proviral latency (GO:0075713)3.20117529
108establishment of protein localization to mitochondrion (GO:0072655)3.19825693
109DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.16728740
110cotranslational protein targeting to membrane (GO:0006613)3.13862953
111GTP biosynthetic process (GO:0006183)3.13706298
112translational initiation (GO:0006413)3.13307949
113kinetochore organization (GO:0051383)3.12946326
114positive regulation of cell cycle arrest (GO:0071158)3.12637439
115metaphase plate congression (GO:0051310)3.12216202
116SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.12043888
117telomere maintenance via recombination (GO:0000722)3.11358325
118DNA strand elongation (GO:0022616)3.09125098
119cytochrome complex assembly (GO:0017004)3.08998841
120DNA-templated transcription, elongation (GO:0006354)3.08235167
121mitochondrial respiratory chain complex assembly (GO:0033108)3.06554872
122nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.06415390
123protein targeting to ER (GO:0045047)3.05366305
124replication fork processing (GO:0031297)3.02412407
125spindle checkpoint (GO:0031577)2.98877249
126negative regulation of mitotic sister chromatid separation (GO:2000816)2.93864990
127negative regulation of sister chromatid segregation (GO:0033046)2.93864990
128negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.93864990
129negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.93864990
130negative regulation of mitotic sister chromatid segregation (GO:0033048)2.93864990
131mitotic spindle checkpoint (GO:0071174)2.93405980
132water-soluble vitamin biosynthetic process (GO:0042364)2.87385423
133protein localization to mitochondrion (GO:0070585)2.86232707
134negative regulation of chromosome segregation (GO:0051985)2.85176263
135oxidative phosphorylation (GO:0006119)2.81593569
136non-recombinational repair (GO:0000726)2.81153234
137double-strand break repair via nonhomologous end joining (GO:0006303)2.81153234
138mitotic recombination (GO:0006312)2.79234644
139pseudouridine synthesis (GO:0001522)2.78272549
140negative regulation of DNA recombination (GO:0045910)2.76671597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.16857220
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.81213556
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.38036220
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.25960957
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.24696194
6* MYC_18555785_ChIP-Seq_MESCs_Mouse4.00438600
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.78594321
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.54502061
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.44688685
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.19985899
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.09253496
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.05008651
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.97478449
14* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.91567687
15* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89422142
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.78964547
17* VDR_23849224_ChIP-Seq_CD4+_Human2.78286083
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76998585
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72960523
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69777966
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.63713468
22ELK1_19687146_ChIP-ChIP_HELA_Human2.45901100
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39000811
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.33804203
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25579958
26DCP1A_22483619_ChIP-Seq_HELA_Human2.24919815
27FOXP3_21729870_ChIP-Seq_TREG_Human2.22686492
28XRN2_22483619_ChIP-Seq_HELA_Human2.21950565
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.20161117
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18342359
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.18184952
32SRF_21415370_ChIP-Seq_HL-1_Mouse2.08810317
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.07022222
34* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.05530254
35YY1_21170310_ChIP-Seq_MESCs_Mouse2.05187202
36ZNF274_21170338_ChIP-Seq_K562_Hela2.03939513
37TTF2_22483619_ChIP-Seq_HELA_Human2.02235097
38* GABP_19822575_ChIP-Seq_HepG2_Human1.97878053
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94563688
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89062939
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86816892
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.85958439
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83229399
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81495513
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79103457
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76698392
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73039202
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72636652
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.70861801
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61640199
51IGF1R_20145208_ChIP-Seq_DFB_Human1.60084253
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56309571
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54556335
54* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53712657
55TAF15_26573619_Chip-Seq_HEK293_Human1.52009844
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.51140203
57AR_21909140_ChIP-Seq_LNCAP_Human1.50381888
58P300_19829295_ChIP-Seq_ESCs_Human1.45107800
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38132494
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35817174
61ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.33696721
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32696563
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26564595
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22431233
65MYC_18940864_ChIP-ChIP_HL60_Human1.20543828
66* E2F1_21310950_ChIP-Seq_MCF-7_Human1.20148379
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19103896
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18575858
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15223792
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14855891
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13771793
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11588160
73KDM5A_27292631_Chip-Seq_BREAST_Human1.10899424
74IRF1_19129219_ChIP-ChIP_H3396_Human1.09654319
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09575068
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08207557
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.06149655
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.05903367
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03478837
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.03015418
81* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02548484
82CIITA_25753668_ChIP-Seq_RAJI_Human1.02164263
83* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01392885
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01372400
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00803505
86* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00683359
87FUS_26573619_Chip-Seq_HEK293_Human1.00451211
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00020285
89SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97242958
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95197215
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94500417
92* EZH2_27294783_Chip-Seq_NPCs_Mouse0.93880277
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92570171
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91440970
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91391766
96EWS_26573619_Chip-Seq_HEK293_Human0.90675154
97NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88694043
98* SOX17_20123909_ChIP-Seq_XEN_Mouse0.88416671
99* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86002204
100* NFE2_27457419_Chip-Seq_LIVER_Mouse0.85930190
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85294122
102GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85292639
103PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85011796
104SOX2_19829295_ChIP-Seq_ESCs_Human0.85010422
105NANOG_19829295_ChIP-Seq_ESCs_Human0.85010422
106VDR_22108803_ChIP-Seq_LS180_Human0.84728765
107TP53_22573176_ChIP-Seq_HFKS_Human0.84257266
108GBX2_23144817_ChIP-Seq_PC3_Human0.83154223
109* FLI1_27457419_Chip-Seq_LIVER_Mouse0.81906781
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81881647
111KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81624195
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81382493
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79478165
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78893984
115TFEB_21752829_ChIP-Seq_HELA_Human0.77934753
116E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77913116
117TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77019186
118IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.77015392
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.76427594
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76299186
121* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72534038
122* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70613136
123FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.70245469
124* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.69919023
125SOX2_16153702_ChIP-ChIP_HESCs_Human0.68874762
126* NANOG_16153702_ChIP-ChIP_HESCs_Human0.68414745
127* SPI1_23547873_ChIP-Seq_NB4_Human0.68180332

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.83370080
2MP0004957_abnormal_blastocyst_morpholog3.99973779
3MP0010094_abnormal_chromosome_stability3.56898085
4MP0008057_abnormal_DNA_replication3.45117433
5MP0008058_abnormal_DNA_repair3.36668738
6MP0003123_paternal_imprinting3.20637142
7MP0003077_abnormal_cell_cycle3.13762341
8* MP0003111_abnormal_nucleus_morphology2.84758244
9MP0001529_abnormal_vocalization2.69174227
10MP0008932_abnormal_embryonic_tissue2.62602388
11MP0003718_maternal_effect2.54152763
12MP0003786_premature_aging2.41986692
13MP0008007_abnormal_cellular_replicative2.36800488
14MP0008877_abnormal_DNA_methylation2.33958412
15MP0002163_abnormal_gland_morphology2.32603256
16MP0006292_abnormal_olfactory_placode2.19634906
17MP0003315_abnormal_perineum_morphology1.92967484
18MP0003121_genomic_imprinting1.88070742
19MP0008260_abnormal_autophagy1.84519337
20MP0001905_abnormal_dopamine_level1.74634403
21MP0003880_abnormal_central_pattern1.70567444
22MP0003806_abnormal_nucleotide_metabolis1.58595325
23MP0009379_abnormal_foot_pigmentation1.57277910
24MP0005084_abnormal_gallbladder_morpholo1.54530279
25MP0009697_abnormal_copulation1.53946134
26MP0003122_maternal_imprinting1.52579375
27MP0002102_abnormal_ear_morphology1.52283197
28MP0001188_hyperpigmentation1.48994655
29MP0002938_white_spotting1.45038608
30MP0000350_abnormal_cell_proliferation1.42211735
31MP0009333_abnormal_splenocyte_physiolog1.40286531
32MP0002638_abnormal_pupillary_reflex1.38619399
33MP0005253_abnormal_eye_physiology1.37883158
34MP0001730_embryonic_growth_arrest1.37128801
35MP0002233_abnormal_nose_morphology1.35775798
36MP0003119_abnormal_digestive_system1.35512463
37MP0002277_abnormal_respiratory_mucosa1.29368128
38MP0003195_calcinosis1.27651774
39MP0005379_endocrine/exocrine_gland_phen1.27249309
40MP0002160_abnormal_reproductive_system1.27135988
41MP0006035_abnormal_mitochondrial_morpho1.25903536
42MP0006276_abnormal_autonomic_nervous1.24413970
43MP0002210_abnormal_sex_determination1.23360979
44MP0004147_increased_porphyrin_level1.21844096
45MP0000049_abnormal_middle_ear1.21216899
46MP0003186_abnormal_redox_activity1.19758598
47MP0002234_abnormal_pharynx_morphology1.19651097
48MP0000372_irregular_coat_pigmentation1.18664511
49MP0001286_abnormal_eye_development1.16446864
50MP0002090_abnormal_vision1.12613102
51MP0004215_abnormal_myocardial_fiber1.12070910
52MP0005389_reproductive_system_phenotype1.11738250
53MP0003136_yellow_coat_color1.11663019
54MP0003011_delayed_dark_adaptation1.10931928
55MP0008789_abnormal_olfactory_epithelium1.09206481
56MP0006036_abnormal_mitochondrial_physio1.08468928
57MP0000566_synostosis1.07763245
58MP0002132_abnormal_respiratory_system1.06223176
59MP0001485_abnormal_pinna_reflex1.05646665
60MP0005671_abnormal_response_to1.04322385
61MP0005551_abnormal_eye_electrophysiolog1.03771387
62MP0003941_abnormal_skin_development1.03099330
63MP0003787_abnormal_imprinting1.03009726
64MP0000647_abnormal_sebaceous_gland1.02681474
65MP0001542_abnormal_bone_strength1.00612727
66MP0002084_abnormal_developmental_patter1.00128828
67MP0001145_abnormal_male_reproductive0.99974270
68MP0000313_abnormal_cell_death0.99778838
69MP0002751_abnormal_autonomic_nervous0.98828560
70MP0001764_abnormal_homeostasis0.98101691
71MP0001697_abnormal_embryo_size0.97867912
72MP0001929_abnormal_gametogenesis0.95555652
73MP0002837_dystrophic_cardiac_calcinosis0.95306514
74MP0002396_abnormal_hematopoietic_system0.95107471
75MP0006072_abnormal_retinal_apoptosis0.91765883
76MP0000653_abnormal_sex_gland0.91289247
77MP0001177_atelectasis0.90556872
78MP0005391_vision/eye_phenotype0.90190690
79MP0001986_abnormal_taste_sensitivity0.89885956
80MP0005367_renal/urinary_system_phenotyp0.89424036
81MP0000516_abnormal_urinary_system0.89424036
82MP0009672_abnormal_birth_weight0.87521507
83MP0000358_abnormal_cell_content/0.86746320
84MP0001119_abnormal_female_reproductive0.86241034
85MP0002254_reproductive_system_inflammat0.85828081
86MP0001919_abnormal_reproductive_system0.85298448
87MP0002697_abnormal_eye_size0.84645593
88MP0002111_abnormal_tail_morphology0.83617475
89MP0002148_abnormal_hypersensitivity_rea0.82661092
90MP0009785_altered_susceptibility_to0.82570693
91MP0005408_hypopigmentation0.82295929
92MP0001299_abnormal_eye_distance/0.82008142
93MP0001672_abnormal_embryogenesis/_devel0.80778224
94MP0005380_embryogenesis_phenotype0.80778224
95* MP0002080_prenatal_lethality0.80371774
96MP0004133_heterotaxia0.79910378
97MP0000490_abnormal_crypts_of0.79748285
98MP0003938_abnormal_ear_development0.77863830
99MP0002282_abnormal_trachea_morphology0.76784017
100MP0002095_abnormal_skin_pigmentation0.75590925
101MP0003567_abnormal_fetal_cardiomyocyte0.75250630
102MP0005499_abnormal_olfactory_system0.74963363
103MP0005394_taste/olfaction_phenotype0.74963363
104* MP0003755_abnormal_palate_morphology0.74673320
105MP0003763_abnormal_thymus_physiology0.74205422
106MP0001968_abnormal_touch/_nociception0.73674209
107MP0002019_abnormal_tumor_incidence0.73280567
108MP0005187_abnormal_penis_morphology0.72869836
109MP0002736_abnormal_nociception_after0.72660642
110MP0002085_abnormal_embryonic_tissue0.71914555
111MP0004142_abnormal_muscle_tone0.71743793
112MP0008872_abnormal_physiological_respon0.71195670
113MP0009046_muscle_twitch0.70597607
114MP0003890_abnormal_embryonic-extraembry0.69791127
115MP0001727_abnormal_embryo_implantation0.68706705
116MP0010386_abnormal_urinary_bladder0.67964025
117MP0003984_embryonic_growth_retardation0.65793961
118MP0010030_abnormal_orbit_morphology0.65178431
119MP0002876_abnormal_thyroid_physiology0.64727960
120MP0003937_abnormal_limbs/digits/tail_de0.64590026
121MP0005171_absent_coat_pigmentation0.63754770
122MP0001984_abnormal_olfaction0.61787657
123MP0002088_abnormal_embryonic_growth/wei0.61259812
124MP0000631_abnormal_neuroendocrine_gland0.60854671
125MP0003698_abnormal_male_reproductive0.60400127
126MP0002398_abnormal_bone_marrow0.58587005
127MP0004808_abnormal_hematopoietic_stem0.58373700
128MP0001835_abnormal_antigen_presentation0.58032893
129MP0005395_other_phenotype0.57692528
130MP0001293_anophthalmia0.56732299
131MP0008995_early_reproductive_senescence0.56122643
132MP0005384_cellular_phenotype0.55733845
133MP0002722_abnormal_immune_system0.55615678
134MP0000689_abnormal_spleen_morphology0.55602312

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.88709996
2Acute necrotizing encephalopathy (HP:0006965)4.76430501
3Abnormal mitochondria in muscle tissue (HP:0008316)4.32788681
4Mitochondrial inheritance (HP:0001427)4.12290310
5Progressive macrocephaly (HP:0004481)3.88429573
6Increased CSF lactate (HP:0002490)3.72222801
7Breast hypoplasia (HP:0003187)3.67184136
8Hepatocellular necrosis (HP:0001404)3.54011854
9Acute encephalopathy (HP:0006846)3.48084621
10Abnormality of cells of the erythroid lineage (HP:0012130)3.29085976
11Increased hepatocellular lipid droplets (HP:0006565)3.23689140
12Irregular epiphyses (HP:0010582)3.15011894
13Methylmalonic acidemia (HP:0002912)3.13710794
14Increased serum pyruvate (HP:0003542)3.12446922
15Abnormality of glycolysis (HP:0004366)3.12446922
16Abnormal number of erythroid precursors (HP:0012131)3.10730039
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.10493724
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.10493724
19Cerebral hypomyelination (HP:0006808)3.04843154
203-Methylglutaconic aciduria (HP:0003535)3.03737475
21Carpal bone hypoplasia (HP:0001498)2.96890289
22Reticulocytopenia (HP:0001896)2.87860745
23Hepatic necrosis (HP:0002605)2.86068535
24Abnormality of the anterior horn cell (HP:0006802)2.83100638
25Degeneration of anterior horn cells (HP:0002398)2.83100638
26Patellar aplasia (HP:0006443)2.72920585
27Increased serum lactate (HP:0002151)2.72163003
28Aplastic anemia (HP:0001915)2.69796079
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.69659314
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.67712318
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.61284028
32Aplasia/Hypoplasia of the patella (HP:0006498)2.60972742
33Abnormality of the labia minora (HP:0012880)2.60243680
34Rough bone trabeculation (HP:0100670)2.60072106
35Lipid accumulation in hepatocytes (HP:0006561)2.59768604
36Pancreatic fibrosis (HP:0100732)2.59658498
37Exercise intolerance (HP:0003546)2.56773740
38Abnormality of methionine metabolism (HP:0010901)2.56127117
39Oral leukoplakia (HP:0002745)2.51936338
40Renal Fanconi syndrome (HP:0001994)2.49986791
41Methylmalonic aciduria (HP:0012120)2.48566341
42Hyperglycinemia (HP:0002154)2.45486057
43Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.42921755
44Exertional dyspnea (HP:0002875)2.40820418
45Septo-optic dysplasia (HP:0100842)2.39808758
46Macrocytic anemia (HP:0001972)2.39552497
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.38644937
48Respiratory difficulties (HP:0002880)2.37986023
49Respiratory failure (HP:0002878)2.35480913
50Pancreatic cysts (HP:0001737)2.34527633
51Abnormality of alanine metabolism (HP:0010916)2.33187632
52Hyperalaninemia (HP:0003348)2.33187632
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33187632
54Type 2 muscle fiber atrophy (HP:0003554)2.31248047
55Abnormality of serum amino acid levels (HP:0003112)2.31189109
56Hypoplasia of the capital femoral epiphysis (HP:0003090)2.29497853
57Medial flaring of the eyebrow (HP:0010747)2.28185525
58Type I transferrin isoform profile (HP:0003642)2.27089419
59Lactic acidosis (HP:0003128)2.26045117
60Optic disc pallor (HP:0000543)2.20423220
61Supernumerary spleens (HP:0009799)2.16813587
62True hermaphroditism (HP:0010459)2.16167655
63Abnormal hair whorl (HP:0010721)2.14893327
64Pallor (HP:0000980)2.14816275
65Nephrogenic diabetes insipidus (HP:0009806)2.14716579
66Microvesicular hepatic steatosis (HP:0001414)2.14700840
67Intestinal atresia (HP:0011100)2.14360266
68Abnormality of the preputium (HP:0100587)2.13134054
69Absent epiphyses (HP:0010577)2.12711740
70Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.12711740
71Volvulus (HP:0002580)2.12450827
72Duodenal stenosis (HP:0100867)2.12197901
73Small intestinal stenosis (HP:0012848)2.12197901
74Meckel diverticulum (HP:0002245)2.11515506
75Congenital primary aphakia (HP:0007707)2.11036485
76Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.09588236
77Muscle fiber atrophy (HP:0100295)2.07827995
78Leukodystrophy (HP:0002415)2.06721659
79Abnormal trabecular bone morphology (HP:0100671)2.06146993
80Megaloblastic anemia (HP:0001889)2.03945156
81Abnormality of the duodenum (HP:0002246)2.03925536
82Cleft eyelid (HP:0000625)2.03514355
83CNS hypomyelination (HP:0003429)2.03483020
84Abnormal lung lobation (HP:0002101)2.02614420
85Increased intramyocellular lipid droplets (HP:0012240)2.02526556
86Gait imbalance (HP:0002141)2.00343116
87Molar tooth sign on MRI (HP:0002419)1.99565118
88Abnormality of midbrain morphology (HP:0002418)1.99565118
89Abnormality of the ileum (HP:0001549)1.98091429
90Absent radius (HP:0003974)1.96702552
91Premature graying of hair (HP:0002216)1.95995444
92Stenosis of the external auditory canal (HP:0000402)1.95703435
93Cerebral edema (HP:0002181)1.94928102
94Lethargy (HP:0001254)1.94101364
95Aplasia/hypoplasia of the uterus (HP:0008684)1.92834912
96Abnormality of serine family amino acid metabolism (HP:0010894)1.92226914
97Abnormality of glycine metabolism (HP:0010895)1.92226914
98Secondary amenorrhea (HP:0000869)1.92027443
99Reduced antithrombin III activity (HP:0001976)1.91311004
100Abnormal protein glycosylation (HP:0012346)1.90902197
101Abnormal glycosylation (HP:0012345)1.90902197
102Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90902197
103Abnormal protein N-linked glycosylation (HP:0012347)1.90902197
104Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90459877
105Microretrognathia (HP:0000308)1.90003130
106Colon cancer (HP:0003003)1.89531148
107Abnormality of the vitamin B12 metabolism (HP:0004341)1.87302326
108Postnatal microcephaly (HP:0005484)1.86689827
109Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86443079
110Pancreatic islet-cell hyperplasia (HP:0004510)1.85933737
111Unsteady gait (HP:0002317)1.85389103
112IgG deficiency (HP:0004315)1.85247606
113Abnormality of vitamin B metabolism (HP:0004340)1.84863687
114Ependymoma (HP:0002888)1.84227589
115Horseshoe kidney (HP:0000085)1.83684203
116Chromsome breakage (HP:0040012)1.82954592
117Neoplasm of the adrenal gland (HP:0100631)1.82344502
118Hyperglycinuria (HP:0003108)1.82329001
119Aplasia involving forearm bones (HP:0009822)1.81685383
120Absent forearm bone (HP:0003953)1.81685383
121CNS demyelination (HP:0007305)1.80547060
122Absent septum pellucidum (HP:0001331)1.80010496
123Bifid tongue (HP:0010297)1.79929055
124Genital tract atresia (HP:0001827)1.77709022
125Nephronophthisis (HP:0000090)1.77494652
126Emotional lability (HP:0000712)1.77437053
127Facial cleft (HP:0002006)1.76573353
128Glossoptosis (HP:0000162)1.76277734
129Sloping forehead (HP:0000340)1.76196121
130Multiple enchondromatosis (HP:0005701)1.74663248
131Abnormality of chromosome stability (HP:0003220)1.74125766
132Congenital, generalized hypertrichosis (HP:0004540)1.73298039
133Hypothermia (HP:0002045)1.73016113
134Vaginal atresia (HP:0000148)1.72907194
135Hypoglycemic coma (HP:0001325)1.72536784
136Nephroblastoma (Wilms tumor) (HP:0002667)1.72380829
137Agnosia (HP:0010524)1.71710900
138Triphalangeal thumb (HP:0001199)1.70656838
139Embryonal renal neoplasm (HP:0011794)1.69096930
140Gastrointestinal atresia (HP:0002589)1.68964697
141Median cleft lip (HP:0000161)1.68670776
142Cellular immunodeficiency (HP:0005374)1.68401689
143Medulloblastoma (HP:0002885)1.68084881

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.59449473
2EIF2AK13.65745317
3WEE13.58642851
4STK163.34829518
5TRIM283.10243386
6VRK22.87614627
7SRPK12.81052028
8TSSK62.64087254
9EIF2AK32.56755707
10NME22.39374777
11VRK12.27843903
12ACVR1B2.21617026
13MAP3K122.15780584
14PLK42.14988957
15MKNK12.05232408
16CDC72.04498177
17NME12.04013882
18BRSK22.02840835
19TNIK1.91319331
20PLK31.89705508
21ARAF1.75775792
22MKNK21.74611632
23CCNB11.69223448
24MST41.66806289
25PNCK1.64958573
26MAP4K21.64372141
27BCR1.63232718
28PBK1.56751170
29PLK11.42097357
30CASK1.41347135
31AKT31.35858778
32BRAF1.35019331
33TAF11.27562643
34CDK81.23595255
35FRK1.21214659
36PIM21.15792053
37MAP3K41.15351502
38EIF2AK21.14762292
39BRSK11.14671955
40ZAK1.08962208
41NEK11.06250724
42PLK21.04995989
43TESK21.04034391
44TTK1.03518886
45DYRK31.02498270
46AURKB1.02384076
47GRK11.01275013
48TLK11.00889874
49AURKA1.00203042
50CSNK1G21.00062791
51BMPR1B0.95134987
52DYRK20.94208008
53BMPR20.92844937
54ERBB30.90743008
55LIMK10.87230893
56STK38L0.81980882
57CHEK20.81912775
58TXK0.79985661
59PASK0.79931234
60SIK30.79664473
61ATR0.77829597
62ADRBK20.77192042
63CSNK2A10.77012120
64CSNK1A1L0.76918493
65NEK20.76440962
66CDK190.75110256
67CDK70.67104859
68BCKDK0.67043717
69YES10.66561476
70MYLK0.65110600
71CSNK1G30.64560732
72EPHA40.64357840
73INSRR0.63573851
74CSNK2A20.63535679
75WNK30.63463963
76MINK10.62882302
77RPS6KA40.62440271
78NEK60.61651226
79NUAK10.61182495
80PRKCG0.59675834
81TESK10.59205702
82MAP2K70.59124606
83STK30.58353340
84EPHA20.58277789
85GRK70.57138112
86TGFBR10.54968550
87STK240.54352512
88RPS6KA50.54288867
89ERBB40.54257587
90MAPK130.53559588
91STK390.53292351
92PRKCE0.53058527
93MUSK0.52725709
94TIE10.49915011
95RPS6KB20.49862315
96PINK10.49765268
97CHEK10.48784314
98PDK20.48575707
99PRKCI0.47755157
100IRAK30.47452797
101FGFR10.46655349
102ALK0.46073797
103GRK50.43948636
104DAPK10.43691046
105CDK30.43659796
106PDK40.42800393
107PDK30.42800393
108CSNK1E0.42437082
109PAK10.41396558
110IRAK40.40921448
111FGFR20.40742318
112KDR0.38208650
113OXSR10.38124365
114TEC0.35089608
115ABL20.34809059
116ATM0.34236458
117PIM10.33925222
118PAK30.33319792
119CSNK1A10.32657567
120CSNK1G10.31432936
121CDK10.31291902
122CDK20.30458395
123CDK140.28561335
124PAK40.27145467
125FLT30.26970494
126CDK180.26485844
127IKBKB0.25941732
128STK40.25595338
129PRKDC0.25588662
130CAMK2A0.24426575

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.15024587
2RNA polymerase_Homo sapiens_hsa030204.11989738
3Ribosome_Homo sapiens_hsa030103.86515295
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.24056230
5DNA replication_Homo sapiens_hsa030303.21046663
6Oxidative phosphorylation_Homo sapiens_hsa001903.08343575
7Mismatch repair_Homo sapiens_hsa034303.04452302
8Spliceosome_Homo sapiens_hsa030402.84409796
9Parkinsons disease_Homo sapiens_hsa050122.67867497
10Pyrimidine metabolism_Homo sapiens_hsa002402.50362521
11Nucleotide excision repair_Homo sapiens_hsa034202.49017851
12Protein export_Homo sapiens_hsa030602.45399927
13* RNA transport_Homo sapiens_hsa030132.43722392
14Homologous recombination_Homo sapiens_hsa034402.38359452
15Basal transcription factors_Homo sapiens_hsa030222.30128140
16Huntingtons disease_Homo sapiens_hsa050162.20492707
17Cell cycle_Homo sapiens_hsa041102.02207074
18Base excision repair_Homo sapiens_hsa034102.00635230
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93169215
20Propanoate metabolism_Homo sapiens_hsa006401.84633692
21RNA degradation_Homo sapiens_hsa030181.82584586
22Alzheimers disease_Homo sapiens_hsa050101.73809562
23Fanconi anemia pathway_Homo sapiens_hsa034601.60717821
24Purine metabolism_Homo sapiens_hsa002301.60124299
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57346943
26Non-homologous end-joining_Homo sapiens_hsa034501.51658448
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40669967
28Steroid biosynthesis_Homo sapiens_hsa001001.40424029
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38462386
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37613762
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.37204486
32Pyruvate metabolism_Homo sapiens_hsa006201.34391981
33Fatty acid elongation_Homo sapiens_hsa000621.31391832
34Collecting duct acid secretion_Homo sapiens_hsa049661.31062066
35Epstein-Barr virus infection_Homo sapiens_hsa051691.18497578
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16032974
37Vitamin B6 metabolism_Homo sapiens_hsa007501.14602219
38mRNA surveillance pathway_Homo sapiens_hsa030151.07263375
39p53 signaling pathway_Homo sapiens_hsa041151.05066330
40Regulation of autophagy_Homo sapiens_hsa041401.04718223
41Selenocompound metabolism_Homo sapiens_hsa004501.03785304
42Butanoate metabolism_Homo sapiens_hsa006501.03224837
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99120688
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95260935
45Oocyte meiosis_Homo sapiens_hsa041140.95173436
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94502512
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94202639
48One carbon pool by folate_Homo sapiens_hsa006700.85811570
49Rheumatoid arthritis_Homo sapiens_hsa053230.84188464
50Vibrio cholerae infection_Homo sapiens_hsa051100.82728161
51Allograft rejection_Homo sapiens_hsa053300.82363032
52Peroxisome_Homo sapiens_hsa041460.80827581
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80294217
54Graft-versus-host disease_Homo sapiens_hsa053320.79864506
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78300573
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76621737
57Carbon metabolism_Homo sapiens_hsa012000.74011453
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73400709
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70543289
60Caffeine metabolism_Homo sapiens_hsa002320.69571185
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66238986
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66153605
63Antigen processing and presentation_Homo sapiens_hsa046120.66086719
64Type I diabetes mellitus_Homo sapiens_hsa049400.65830697
65Biosynthesis of amino acids_Homo sapiens_hsa012300.64974372
66Sulfur metabolism_Homo sapiens_hsa009200.64214575
67Cardiac muscle contraction_Homo sapiens_hsa042600.63752079
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61599757
69Tryptophan metabolism_Homo sapiens_hsa003800.60514790
70Autoimmune thyroid disease_Homo sapiens_hsa053200.60206190
71Folate biosynthesis_Homo sapiens_hsa007900.59105397
72beta-Alanine metabolism_Homo sapiens_hsa004100.58711971
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58650016
74Phototransduction_Homo sapiens_hsa047440.56604790
75Legionellosis_Homo sapiens_hsa051340.55706955
76Fatty acid degradation_Homo sapiens_hsa000710.55346481
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.54843853
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54031307
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53503442
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50952713
81Fatty acid metabolism_Homo sapiens_hsa012120.50532910
82Pentose phosphate pathway_Homo sapiens_hsa000300.50216631
83Nicotine addiction_Homo sapiens_hsa050330.50151132
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50124251
85Retinol metabolism_Homo sapiens_hsa008300.50020343
86Herpes simplex infection_Homo sapiens_hsa051680.49608959
87Arachidonic acid metabolism_Homo sapiens_hsa005900.48908535
88Primary immunodeficiency_Homo sapiens_hsa053400.48838095
89Chemical carcinogenesis_Homo sapiens_hsa052040.48246897
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.47492735
91Asthma_Homo sapiens_hsa053100.45986224
92Vitamin digestion and absorption_Homo sapiens_hsa049770.44691385
93Metabolic pathways_Homo sapiens_hsa011000.44628277
94Glutathione metabolism_Homo sapiens_hsa004800.44298513
95Systemic lupus erythematosus_Homo sapiens_hsa053220.41015428
96Synaptic vesicle cycle_Homo sapiens_hsa047210.40963952
97Nitrogen metabolism_Homo sapiens_hsa009100.40492909
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.40188136
99Phagosome_Homo sapiens_hsa041450.40124165
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36509524
101Viral carcinogenesis_Homo sapiens_hsa052030.35182535
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.35175052
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34710145
104Arginine and proline metabolism_Homo sapiens_hsa003300.34570602
105Basal cell carcinoma_Homo sapiens_hsa052170.32364769
106Hedgehog signaling pathway_Homo sapiens_hsa043400.32128034
107Fructose and mannose metabolism_Homo sapiens_hsa000510.32095067
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31472701
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31407757
110Fat digestion and absorption_Homo sapiens_hsa049750.31021341
111Alcoholism_Homo sapiens_hsa050340.30707139
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29834359
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26881214
114Shigellosis_Homo sapiens_hsa051310.25744857
115Sphingolipid metabolism_Homo sapiens_hsa006000.25473476
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25337649
117Wnt signaling pathway_Homo sapiens_hsa043100.25311862
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.23686232
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.22910256
120Hippo signaling pathway_Homo sapiens_hsa043900.22474301
121HTLV-I infection_Homo sapiens_hsa051660.21557302
122Hematopoietic cell lineage_Homo sapiens_hsa046400.21289502
123Measles_Homo sapiens_hsa051620.21149961
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18142877
125Taste transduction_Homo sapiens_hsa047420.17568637
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16315804
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15805492
128Serotonergic synapse_Homo sapiens_hsa047260.13151498
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.10727963
130N-Glycan biosynthesis_Homo sapiens_hsa005100.10489248
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10210293
132TGF-beta signaling pathway_Homo sapiens_hsa043500.09186200
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07905251
134NF-kappa B signaling pathway_Homo sapiens_hsa040640.07388189
135Thyroid cancer_Homo sapiens_hsa052160.06974411
136Circadian rhythm_Homo sapiens_hsa047100.06627885
137Ether lipid metabolism_Homo sapiens_hsa005650.06205577
138Other glycan degradation_Homo sapiens_hsa005110.05529618
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05494612
140Amphetamine addiction_Homo sapiens_hsa050310.03810668
141Linoleic acid metabolism_Homo sapiens_hsa005910.03651227
142Influenza A_Homo sapiens_hsa051640.03434993
143Hepatitis B_Homo sapiens_hsa051610.02997178

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