SULT6B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of memory T cell differentiation (GO:0043380)5.72999757
2fucose catabolic process (GO:0019317)5.61100513
3L-fucose metabolic process (GO:0042354)5.61100513
4L-fucose catabolic process (GO:0042355)5.61100513
5regulation of MHC class I biosynthetic process (GO:0045343)5.55506729
6sequestering of actin monomers (GO:0042989)5.37762449
7negative regulation of type 2 immune response (GO:0002829)5.29722408
8negative regulation of multicellular organism growth (GO:0040015)5.22540239
9gamma-aminobutyric acid transport (GO:0015812)5.21888037
10negative regulation of synaptic transmission, GABAergic (GO:0032229)4.89562862
11neurofilament cytoskeleton organization (GO:0060052)4.89483760
12DNA strand elongation involved in DNA replication (GO:0006271)4.74279693
13cytidine deamination (GO:0009972)4.73635017
14cytidine metabolic process (GO:0046087)4.73635017
15cytidine catabolic process (GO:0006216)4.73635017
16regulation of helicase activity (GO:0051095)4.70448486
17regulation of establishment of cell polarity (GO:2000114)4.67410054
18regulation of action potential (GO:0098900)4.64285337
19telomere maintenance via semi-conservative replication (GO:0032201)4.55826930
20DNA strand elongation (GO:0022616)4.51656403
21nuclear pore organization (GO:0006999)4.39458911
22sex differentiation (GO:0007548)4.38078726
23pyrimidine ribonucleoside catabolic process (GO:0046133)4.25277180
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.25116729
25tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.25116729
26DNA replication initiation (GO:0006270)4.20924147
27protein localization to kinetochore (GO:0034501)4.20341262
28regulation of establishment or maintenance of cell polarity (GO:0032878)4.14515679
29purine nucleobase biosynthetic process (GO:0009113)4.13951582
30telomere maintenance via recombination (GO:0000722)4.13301292
31DNA unwinding involved in DNA replication (GO:0006268)4.10932887
32regulation of metalloenzyme activity (GO:0048552)4.08847663
33piRNA metabolic process (GO:0034587)4.06196457
34nucleobase biosynthetic process (GO:0046112)4.05626596
35mitotic recombination (GO:0006312)4.03607770
36cholesterol catabolic process (GO:0006707)4.03404036
37sterol catabolic process (GO:0016127)4.03404036
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.03402914
39IMP biosynthetic process (GO:0006188)3.99087961
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.94225134
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.94225134
42NADH dehydrogenase complex assembly (GO:0010257)3.94225134
43pyrimidine nucleobase catabolic process (GO:0006208)3.88911818
44positive regulation of chromosome segregation (GO:0051984)3.86960393
45mitotic nuclear envelope disassembly (GO:0007077)3.85478197
46mitotic metaphase plate congression (GO:0007080)3.85410296
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.85384489
48somatic hypermutation of immunoglobulin genes (GO:0016446)3.82343532
49somatic diversification of immune receptors via somatic mutation (GO:0002566)3.82343532
50phospholipid translocation (GO:0045332)3.81960021
51lipid translocation (GO:0034204)3.81960021
52formation of translation preinitiation complex (GO:0001731)3.81407213
53DNA replication checkpoint (GO:0000076)3.81064216
54nuclear pore complex assembly (GO:0051292)3.78504446
55nucleotide-excision repair, DNA gap filling (GO:0006297)3.75457357
56detection of light stimulus involved in visual perception (GO:0050908)3.74148418
57detection of light stimulus involved in sensory perception (GO:0050962)3.74148418
58inner cell mass cell proliferation (GO:0001833)3.73723357
59kynurenine metabolic process (GO:0070189)3.73277571
60dosage compensation (GO:0007549)3.71889857
61ribosome assembly (GO:0042255)3.71087504
62nuclear envelope disassembly (GO:0051081)3.69128930
63membrane disassembly (GO:0030397)3.69128930
64indole-containing compound catabolic process (GO:0042436)3.68557144
65indolalkylamine catabolic process (GO:0046218)3.68557144
66tryptophan catabolic process (GO:0006569)3.68557144
67telomere maintenance via telomere lengthening (GO:0010833)3.67700828
68regulation of gene silencing by RNA (GO:0060966)3.67192860
69regulation of posttranscriptional gene silencing (GO:0060147)3.67192860
70regulation of gene silencing by miRNA (GO:0060964)3.67192860
71DNA replication-dependent nucleosome assembly (GO:0006335)3.66458707
72DNA replication-dependent nucleosome organization (GO:0034723)3.66458707
73regulation of nuclear cell cycle DNA replication (GO:0033262)3.65500896
74killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.63616905
75disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.63616905
76IMP metabolic process (GO:0046040)3.61176134
77protein localization to chromosome, centromeric region (GO:0071459)3.59743473
78determination of adult lifespan (GO:0008340)3.58603856
79positive regulation of mitotic sister chromatid separation (GO:1901970)3.57806742
80positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.57806742
81positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.57806742
82folic acid-containing compound biosynthetic process (GO:0009396)3.57766137
83regulation of chemokine biosynthetic process (GO:0045073)3.57520128
84ribosome biogenesis (GO:0042254)3.57185247
85metallo-sulfur cluster assembly (GO:0031163)3.54555000
86iron-sulfur cluster assembly (GO:0016226)3.54555000
87nucleobase catabolic process (GO:0046113)3.53302224
88protein complex biogenesis (GO:0070271)3.50997180
89pyrimidine-containing compound catabolic process (GO:0072529)3.47745738
90response to dietary excess (GO:0002021)3.44606327
91positive regulation of B cell differentiation (GO:0045579)3.42788019
92maturation of SSU-rRNA (GO:0030490)3.41713400
93ribonucleoprotein complex biogenesis (GO:0022613)3.40767868
94somite rostral/caudal axis specification (GO:0032525)3.40610867
95lung-associated mesenchyme development (GO:0060484)3.39394142
96cellular response to exogenous dsRNA (GO:0071360)3.39144954
97T cell migration (GO:0072678)3.37649763
98ribosomal large subunit biogenesis (GO:0042273)3.36170442
99regulation of histone H3-K9 methylation (GO:0051570)3.33853028
100fucosylation (GO:0036065)3.32156417
101mitochondrial respiratory chain complex assembly (GO:0033108)3.31372663
102viral transcription (GO:0019083)3.30422708
103DNA geometric change (GO:0032392)3.30236200
104cytoplasmic mRNA processing body assembly (GO:0033962)3.29488040
105DNA demethylation (GO:0080111)3.29241287
106nodal signaling pathway (GO:0038092)3.27484784
107negative regulation of growth of symbiont in host (GO:0044130)3.27109160
108negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.27109160
109modulation of growth of symbiont involved in interaction with host (GO:0044144)3.27109160
110regulation of growth of symbiont in host (GO:0044126)3.27109160
111killing of cells of other organism (GO:0031640)3.26163698
112disruption of cells of other organism (GO:0044364)3.26163698
113DNA duplex unwinding (GO:0032508)3.25868032
114stress granule assembly (GO:0034063)3.24173583
115translational termination (GO:0006415)3.22289807
116mismatch repair (GO:0006298)3.21971429
117regulation of interleukin-13 production (GO:0032656)3.21052508
118adult walking behavior (GO:0007628)3.20703136
119heterochromatin organization (GO:0070828)3.20608539
120tryptophan metabolic process (GO:0006568)3.19418853
121establishment of integrated proviral latency (GO:0075713)3.18235358
122chromatin remodeling at centromere (GO:0031055)3.17805473
123negative regulation of T cell differentiation (GO:0045581)3.16173907
124ribosomal small subunit biogenesis (GO:0042274)3.14677106
125attachment of spindle microtubules to kinetochore (GO:0008608)3.14435374
126RNA-dependent DNA replication (GO:0006278)3.14108182
127pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.11995712
128regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.11158521
129DNA replication-independent nucleosome organization (GO:0034724)3.10434541
130DNA replication-independent nucleosome assembly (GO:0006336)3.10434541
131telomere maintenance (GO:0000723)3.09858327
132DNA deamination (GO:0045006)3.09497998
133cerebellar Purkinje cell differentiation (GO:0021702)3.08932945
134metaphase plate congression (GO:0051310)3.08810186
135translational elongation (GO:0006414)3.08676220
136telomere organization (GO:0032200)3.08334760
137alternative mRNA splicing, via spliceosome (GO:0000380)3.08314453
138translational initiation (GO:0006413)3.08181598
139ribosomal small subunit assembly (GO:0000028)3.06967805
140telomere maintenance via telomerase (GO:0007004)3.06493285
141transcription-coupled nucleotide-excision repair (GO:0006283)3.06350287
142regulation of sequestering of triglyceride (GO:0010889)3.06327400
143positive regulation of protein kinase C signaling (GO:0090037)3.06135982
144ADP metabolic process (GO:0046031)3.04978524
145rRNA modification (GO:0000154)3.04604258
146negative regulation of histone methylation (GO:0031061)3.03307825
147CENP-A containing nucleosome assembly (GO:0034080)3.02793354
148behavioral response to nicotine (GO:0035095)3.02636487
149termination of RNA polymerase III transcription (GO:0006386)3.02579427
150transcription elongation from RNA polymerase III promoter (GO:0006385)3.02579427
151positive regulation of action potential (GO:0045760)3.02230164
152bile acid biosynthetic process (GO:0006699)3.01923514
153regulation of centriole replication (GO:0046599)3.01382378
154pore complex assembly (GO:0046931)3.01097907
155regulation of centrosome cycle (GO:0046605)2.99642572
156positive regulation of defense response to virus by host (GO:0002230)2.99484279
157regulation of feeding behavior (GO:0060259)2.99261868
158deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.99095508
159centriole replication (GO:0007099)2.99032321
160pyrimidine nucleoside catabolic process (GO:0046135)2.98141929
161oxidative phosphorylation (GO:0006119)2.98035562
162regulation of timing of cell differentiation (GO:0048505)2.97097017
163amine catabolic process (GO:0009310)2.95113822
164cellular biogenic amine catabolic process (GO:0042402)2.95113822
165maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.92975977
166sex determination (GO:0007530)2.92710107
167regulation of double-strand break repair via homologous recombination (GO:0010569)2.91441149
168regulation of telomere maintenance via telomerase (GO:0032210)2.90321451
169neuromuscular process controlling posture (GO:0050884)2.89028364
170neuronal action potential (GO:0019228)2.88877230
171mitotic sister chromatid segregation (GO:0000070)2.87379762
172establishment of mitochondrion localization (GO:0051654)2.86974254
173kinetochore organization (GO:0051383)2.86629682
174negative regulation of receptor-mediated endocytosis (GO:0048261)2.86081019
175regulation of interleukin-5 production (GO:0032674)2.86030877
176establishment of chromosome localization (GO:0051303)2.83680962
177nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.82418585
178synaptic transmission, cholinergic (GO:0007271)2.81498696
179rRNA processing (GO:0006364)2.81027804
180positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.80521946
181pre-miRNA processing (GO:0031054)2.78829182
182DNA-dependent DNA replication (GO:0006261)2.78574660
183neutrophil mediated immunity (GO:0002446)2.78151034
184response to interferon-beta (GO:0035456)2.78025883
185rRNA catabolic process (GO:0016075)2.77882044
186protein localization to chromosome (GO:0034502)2.77817855
187regulation of development, heterochronic (GO:0040034)2.77008166
188negative regulation of DNA-dependent DNA replication (GO:2000104)2.76015152
189negative regulation of gene silencing (GO:0060969)2.75876721
190replication fork processing (GO:0031297)2.74040146
191protein K6-linked ubiquitination (GO:0085020)2.72318648
192regulation of sister chromatid cohesion (GO:0007063)2.72281671
193meiotic chromosome segregation (GO:0045132)2.71949054
194rRNA metabolic process (GO:0016072)2.70836079
195positive regulation of SMAD protein import into nucleus (GO:0060391)2.70730283
196DNA conformation change (GO:0071103)2.68959771
197nuclear envelope organization (GO:0006998)2.67844793
198DNA replication (GO:0006260)2.66691528

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.72353362
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.91798173
3EZH2_22144423_ChIP-Seq_EOC_Human4.13063523
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.76683574
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.63236985
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.38629774
7GBX2_23144817_ChIP-Seq_PC3_Human3.24980434
8VDR_22108803_ChIP-Seq_LS180_Human3.21934627
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.05739717
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.82968206
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.74573598
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61201122
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57930611
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.48358297
15ZNF274_21170338_ChIP-Seq_K562_Hela2.44136789
16ER_23166858_ChIP-Seq_MCF-7_Human2.41022713
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.36791280
18NANOG_18555785_ChIP-Seq_MESCs_Mouse2.34108475
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30571874
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.30153518
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.29889699
22TAF15_26573619_Chip-Seq_HEK293_Human2.24763338
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23069948
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.15968489
25IRF1_19129219_ChIP-ChIP_H3396_Human2.15306095
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15226627
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14737461
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.14223547
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.14223547
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.14223547
31NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.13560756
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.11623232
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.06464135
34ETS1_20019798_ChIP-Seq_JURKAT_Human2.06195200
35EGR1_19374776_ChIP-ChIP_THP-1_Human2.05407208
36ETV2_25802403_ChIP-Seq_MESCs_Mouse2.04920038
37STAT3_1855785_ChIP-Seq_MESCs_Mouse2.03312001
38XRN2_22483619_ChIP-Seq_HELA_Human2.02134185
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.00614497
40GABP_17652178_ChIP-ChIP_JURKAT_Human2.00435948
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98957582
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.97621117
43DROSHA_22980978_ChIP-Seq_HELA_Human1.93544320
44REST_21632747_ChIP-Seq_MESCs_Mouse1.93336883
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92194937
46EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.88645346
47VDR_23849224_ChIP-Seq_CD4+_Human1.87474613
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87096164
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83357983
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83130766
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.82358515
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79308829
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.77021542
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76157236
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74205319
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.72963629
57SCL_19346495_ChIP-Seq_HPC-7_Human1.72827274
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.71363087
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70976681
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67867798
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67852434
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66842378
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.66700304
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.63791285
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60214642
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.59811261
67CBP_20019798_ChIP-Seq_JUKART_Human1.59811261
68FOXP3_21729870_ChIP-Seq_TREG_Human1.59746771
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.57243618
70AR_21909140_ChIP-Seq_LNCAP_Human1.56885641
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56581628
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52898417
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51144429
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50545005
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50509968
76SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.49043440
77NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.47717568
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.45486372
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.45486372
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.44931760
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.43943720
82TCF3_18692474_ChIP-Seq_MESCs_Mouse1.43262408
83WDR5_24793694_ChIP-Seq_LNCAP_Human1.43117418
84AR_25329375_ChIP-Seq_VCAP_Human1.42404757
85AUTS2_25519132_ChIP-Seq_293T-REX_Human1.42309341
86DCP1A_22483619_ChIP-Seq_HELA_Human1.40941417
87* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39687405
88TTF2_22483619_ChIP-Seq_HELA_Human1.39389555
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35942808
90IGF1R_20145208_ChIP-Seq_DFB_Human1.34489888
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34372301
92FOXA1_21572438_ChIP-Seq_LNCaP_Human1.34314960
93OCT4_20526341_ChIP-Seq_ESCs_Human1.34107303
94SOX2_18692474_ChIP-Seq_MEFs_Mouse1.33945215
95ELK1_19687146_ChIP-ChIP_HELA_Human1.33684332
96SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.32918069
97YY1_21170310_ChIP-Seq_MESCs_Mouse1.32522167
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31419989
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31298522
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30973260
101MYC_19829295_ChIP-Seq_ESCs_Human1.30949117
102MYC_22102868_ChIP-Seq_BL_Human1.30650520
103THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30216775
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30117859
105FUS_26573619_Chip-Seq_HEK293_Human1.29808083
106SALL1_21062744_ChIP-ChIP_HESCs_Human1.28494960
107NCOR_22424771_ChIP-Seq_293T_Human1.27436177
108* GABP_19822575_ChIP-Seq_HepG2_Human1.27354291
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26265871
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24659423
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23758643
112SOX2_18692474_ChIP-Seq_MESCs_Mouse1.22338899
113YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21933433
114SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21507712
115PIAS1_25552417_ChIP-Seq_VCAP_Human1.18963486
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18885964
117RNF2_27304074_Chip-Seq_NSC_Mouse1.16864923
118NANOG_21062744_ChIP-ChIP_HESCs_Human1.15589078
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15393632
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15064386
121ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14265322
122TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13979767
123CIITA_25753668_ChIP-Seq_RAJI_Human1.12707240
124P300_19829295_ChIP-Seq_ESCs_Human1.12061734
125NANOG_20526341_ChIP-Seq_ESCs_Human1.11916027
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11838360
127SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10777129
128TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10776317
129GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.10775373
130CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10128775
131NANOG_18692474_ChIP-Seq_MEFs_Mouse1.10100076
132* TAF2_19829295_ChIP-Seq_ESCs_Human1.09140799
133HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08859417
134NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08658591
135ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08583600
136* KDM5A_27292631_Chip-Seq_BREAST_Human1.08040984
137TFEB_21752829_ChIP-Seq_HELA_Human1.07637636
138* OCT1_27270436_Chip-Seq_PROSTATE_Human1.06327335
139FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06070019
140OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05254284
141TP63_19390658_ChIP-ChIP_HaCaT_Human1.04896158
142SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03603985
143TCF4_23295773_ChIP-Seq_U87_Human1.03091354
144AR_21572438_ChIP-Seq_LNCaP_Human1.03058528
145BCAT_22108803_ChIP-Seq_LS180_Human1.02698289
146POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.02275081
147KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01118222
148KAP1_27257070_Chip-Seq_ESCs_Mouse0.99440339
149TP63_17297297_ChIP-ChIP_HaCaT_Human0.98825877
150NANOG_18692474_ChIP-Seq_MESCs_Mouse0.98696103
151CTCF_20526341_ChIP-Seq_ESCs_Human0.98598541
152EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98591083
153PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97538585
154NANOG_19829295_ChIP-Seq_ESCs_Human0.97487657
155SOX2_19829295_ChIP-Seq_ESCs_Human0.97487657
156FLI1_21867929_ChIP-Seq_TH2_Mouse0.97311650
157TAL1_26923725_Chip-Seq_HPCs_Mouse0.96650930
158NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95879948
159SMAD4_21799915_ChIP-Seq_A2780_Human0.94706533
160CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94399402
161* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93752979
162RUNX2_22187159_ChIP-Seq_PCA_Human0.93686724
163POU5F1_16518401_ChIP-PET_MESCs_Mouse0.93433865
164FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93314989
165CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93304954
166BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93089560
167SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92749359
168* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92718933
169ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92691242
170* P300_27268052_Chip-Seq_Bcells_Human0.92556257
171RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91822003
172VDR_21846776_ChIP-Seq_THP-1_Human0.91811175
173RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90870707
174ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90862061
175RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90693442
176CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90497030
177PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90348521
178MYC_18940864_ChIP-ChIP_HL60_Human0.89924143
179GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89908133
180* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89783822
181REST_18959480_ChIP-ChIP_MESCs_Mouse0.89562070
182PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88082160
183MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87873221
184AR_20517297_ChIP-Seq_VCAP_Human0.86357572
185ERA_21632823_ChIP-Seq_H3396_Human0.86285821
186PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85968064
187EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85598487
188TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85430708
189AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85231755
190EWS_26573619_Chip-Seq_HEK293_Human0.84670791
191ELF1_20517297_ChIP-Seq_JURKAT_Human0.84216445
192TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83306532
193FLI1_27457419_Chip-Seq_LIVER_Mouse0.82933032

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.88318292
2MP0000566_synostosis4.48182717
3MP0010094_abnormal_chromosome_stability4.46638399
4MP0003693_abnormal_embryo_hatching4.40995434
5MP0003806_abnormal_nucleotide_metabolis4.13279758
6MP0003111_abnormal_nucleus_morphology3.98113992
7MP0004957_abnormal_blastocyst_morpholog3.74109028
8MP0008058_abnormal_DNA_repair3.31389683
9MP0003077_abnormal_cell_cycle3.30672456
10MP0001986_abnormal_taste_sensitivity3.20139892
11MP0002102_abnormal_ear_morphology3.16884282
12MP0004133_heterotaxia3.04093885
13MP0010352_gastrointestinal_tract_polyps2.93970664
14MP0008877_abnormal_DNA_methylation2.90724358
15MP0003880_abnormal_central_pattern2.78563789
16MP0000569_abnormal_digit_pigmentation2.70712686
17MP0008007_abnormal_cellular_replicative2.63639415
18MP0002822_catalepsy2.57848384
19MP0003252_abnormal_bile_duct2.51370654
20MP0009745_abnormal_behavioral_response2.46363106
21MP0003011_delayed_dark_adaptation2.44526604
22MP0009046_muscle_twitch2.36278805
23MP0001968_abnormal_touch/_nociception2.34799949
24MP0003787_abnormal_imprinting2.34425940
25MP0005423_abnormal_somatic_nervous2.31398766
26MP0006072_abnormal_retinal_apoptosis2.24914052
27MP0008995_early_reproductive_senescence2.17620601
28MP0002736_abnormal_nociception_after2.17136370
29MP0000350_abnormal_cell_proliferation2.15637418
30MP0008932_abnormal_embryonic_tissue2.15082051
31MP0002876_abnormal_thyroid_physiology2.14857209
32MP0010307_abnormal_tumor_latency1.95988354
33MP0001730_embryonic_growth_arrest1.91695606
34MP0003123_paternal_imprinting1.79787513
35MP0003786_premature_aging1.73894836
36MP0002272_abnormal_nervous_system1.73428508
37MP0003195_calcinosis1.71948512
38MP0004142_abnormal_muscle_tone1.71049406
39MP0001188_hyperpigmentation1.69592675
40MP0001486_abnormal_startle_reflex1.69550459
41MP0002653_abnormal_ependyma_morphology1.67106268
42MP0005671_abnormal_response_to1.63687932
43MP0002064_seizures1.61834068
44MP0006082_CNS_inflammation1.60842134
45MP0003315_abnormal_perineum_morphology1.60728298
46MP0004134_abnormal_chest_morphology1.58466054
47MP0002837_dystrophic_cardiac_calcinosis1.55534701
48MP0005084_abnormal_gallbladder_morpholo1.50659614
49MP0003718_maternal_effect1.49221941
50MP0005253_abnormal_eye_physiology1.47010148
51MP0002733_abnormal_thermal_nociception1.46465614
52MP0000313_abnormal_cell_death1.44330338
53MP0005380_embryogenesis_phenotype1.43577102
54MP0001672_abnormal_embryogenesis/_devel1.43577102
55MP0003121_genomic_imprinting1.43513388
56MP0003136_yellow_coat_color1.43028186
57MP0004147_increased_porphyrin_level1.42910388
58MP0005551_abnormal_eye_electrophysiolog1.41036327
59MP0001697_abnormal_embryo_size1.40438929
60MP0006035_abnormal_mitochondrial_morpho1.40338148
61MP0004808_abnormal_hematopoietic_stem1.39636238
62MP0002019_abnormal_tumor_incidence1.38829490
63MP0000516_abnormal_urinary_system1.37945588
64MP0005367_renal/urinary_system_phenotyp1.37945588
65MP0002084_abnormal_developmental_patter1.37898142
66MP0000490_abnormal_crypts_of1.36386202
67MP0002080_prenatal_lethality1.34775373
68MP0002085_abnormal_embryonic_tissue1.34319074
69MP0002210_abnormal_sex_determination1.31748129
70MP0002086_abnormal_extraembryonic_tissu1.30685263
71MP0008789_abnormal_olfactory_epithelium1.30234030
72MP0001529_abnormal_vocalization1.29693954
73MP0004924_abnormal_behavior1.28652440
74MP0005386_behavior/neurological_phenoty1.28652440
75MP0003635_abnormal_synaptic_transmissio1.28413334
76MP0004197_abnormal_fetal_growth/weight/1.27628191
77MP0002234_abnormal_pharynx_morphology1.25377392
78MP0006138_congestive_heart_failure1.24125748
79MP0005410_abnormal_fertilization1.23990644
80MP0001849_ear_inflammation1.21157278
81MP0010386_abnormal_urinary_bladder1.20601830
82MP0001293_anophthalmia1.20058913
83MP0002396_abnormal_hematopoietic_system1.19140585
84MP0003984_embryonic_growth_retardation1.18643963
85MP0003137_abnormal_impulse_conducting1.17875914
86MP0002067_abnormal_sensory_capabilities1.16463744
87MP0001145_abnormal_male_reproductive1.16026312
88MP0000689_abnormal_spleen_morphology1.15619925
89MP0002088_abnormal_embryonic_growth/wei1.15556361
90MP0005397_hematopoietic_system_phenotyp1.14189152
91MP0001545_abnormal_hematopoietic_system1.14189152
92MP0001970_abnormal_pain_threshold1.13784294
93MP0009785_altered_susceptibility_to1.12622448
94MP0002398_abnormal_bone_marrow1.09935817
95MP0009278_abnormal_bone_marrow1.09123928
96MP0003186_abnormal_redox_activity1.08701853
97MP0005187_abnormal_penis_morphology1.08203244
98MP0006036_abnormal_mitochondrial_physio1.05604759
99MP0001764_abnormal_homeostasis1.04581263
100MP0002572_abnormal_emotion/affect_behav1.04362252
101MP0002722_abnormal_immune_system1.02956718
102MP0006276_abnormal_autonomic_nervous1.02190372
103MP0000703_abnormal_thymus_morphology1.01913325
104MP0005076_abnormal_cell_differentiation1.01493340
105MP0009333_abnormal_splenocyte_physiolog1.00841484
106MP0003941_abnormal_skin_development1.00729373
107MP0001929_abnormal_gametogenesis1.00481988
108MP0001501_abnormal_sleep_pattern1.00431837
109MP0003566_abnormal_cell_adhesion1.00330274
110MP0003763_abnormal_thymus_physiology0.99758840
111MP0002735_abnormal_chemical_nociception0.99312913
112MP0005266_abnormal_metabolism0.98575223
113MP0002009_preneoplasia0.98142396
114MP0002638_abnormal_pupillary_reflex0.95845413
115MP0005499_abnormal_olfactory_system0.94934344
116MP0005394_taste/olfaction_phenotype0.94934344
117MP0005646_abnormal_pituitary_gland0.94886519
118MP0003567_abnormal_fetal_cardiomyocyte0.94327509
119MP0000653_abnormal_sex_gland0.93875872
120MP0006292_abnormal_olfactory_placode0.92625127
121MP0000371_diluted_coat_color0.90018238
122MP0003448_altered_tumor_morphology0.89921211
123MP0004130_abnormal_muscle_cell0.89822236
124MP0005023_abnormal_wound_healing0.89673790
125MP0005384_cellular_phenotype0.89037069
126MP0000538_abnormal_urinary_bladder0.88820601
127MP0000858_altered_metastatic_potential0.88533423
128MP0001800_abnormal_humoral_immune0.88312111
129MP0005174_abnormal_tail_pigmentation0.87194187
130MP0001299_abnormal_eye_distance/0.86184993
131MP0004145_abnormal_muscle_electrophysio0.85462439
132MP0005025_abnormal_response_to0.84767908
133MP0005621_abnormal_cell_physiology0.84660346
134MP0003119_abnormal_digestive_system0.84569210
135MP0000049_abnormal_middle_ear0.84488850
136MP0002429_abnormal_blood_cell0.84386038
137MP0001963_abnormal_hearing_physiology0.83549412
138MP0004859_abnormal_synaptic_plasticity0.81983410
139MP0001853_heart_inflammation0.81085959
140MP0001835_abnormal_antigen_presentation0.81057772
141MP0001119_abnormal_female_reproductive0.80796874
142MP0003436_decreased_susceptibility_to0.80415272
143MP0002063_abnormal_learning/memory/cond0.79399117
144MP0002277_abnormal_respiratory_mucosa0.79306128
145MP0001440_abnormal_grooming_behavior0.79142005
146MP0000716_abnormal_immune_system0.78582356
147MP0001905_abnormal_dopamine_level0.78216941
148MP0003890_abnormal_embryonic-extraembry0.77632095
149MP0003283_abnormal_digestive_organ0.77055048
150MP0004782_abnormal_surfactant_physiolog0.76900410
151MP0002075_abnormal_coat/hair_pigmentati0.76439390
152MP0002132_abnormal_respiratory_system0.76207752
153MP0004043_abnormal_pH_regulation0.75278077
154MP0002938_white_spotting0.74783125
155MP0000358_abnormal_cell_content/0.74547201
156MP0004742_abnormal_vestibular_system0.74280074
157MP0001915_intracranial_hemorrhage0.74145012
158MP0001485_abnormal_pinna_reflex0.73508711
159MP0002452_abnormal_antigen_presenting0.73254023
160MP0000470_abnormal_stomach_morphology0.73184383
161MP0002751_abnormal_autonomic_nervous0.72190178
162MP0003936_abnormal_reproductive_system0.72080756
163MP0000015_abnormal_ear_pigmentation0.72034798
164MP0003878_abnormal_ear_physiology0.71837927
165MP0005377_hearing/vestibular/ear_phenot0.71837927
166MP0002405_respiratory_system_inflammati0.71042219
167MP0005409_darkened_coat_color0.70853548
168MP0002006_tumorigenesis0.70454882
169MP0002163_abnormal_gland_morphology0.70268059
170MP0005332_abnormal_amino_acid0.68538646
171MP0002138_abnormal_hepatobiliary_system0.68181011
172MP0002148_abnormal_hypersensitivity_rea0.66824638
173MP0005395_other_phenotype0.65921961
174MP0000026_abnormal_inner_ear0.65474645
175MP0009763_increased_sensitivity_to0.64512530
176MP0002282_abnormal_trachea_morphology0.63088590
177MP0000685_abnormal_immune_system0.61664483
178MP0005636_abnormal_mineral_homeostasis0.60535693
179MP0002161_abnormal_fertility/fecundity0.60030922
180MP0003698_abnormal_male_reproductive0.59406664
181MP0003633_abnormal_nervous_system0.58318397

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)5.31029865
2Birth length less than 3rd percentile (HP:0003561)5.02566143
3Progressive cerebellar ataxia (HP:0002073)4.47244670
4Prostate neoplasm (HP:0100787)4.34412978
5Inability to walk (HP:0002540)4.31513880
6Abnormality of the prostate (HP:0008775)4.30105056
7Breast hypoplasia (HP:0003187)4.24975194
8Absence seizures (HP:0002121)4.10699970
9Action tremor (HP:0002345)4.08113142
10Carpal bone hypoplasia (HP:0001498)4.07503810
11Stenosis of the external auditory canal (HP:0000402)4.05607900
12Gaze-evoked nystagmus (HP:0000640)4.04771350
13Absent radius (HP:0003974)3.84195346
14Agnosia (HP:0010524)3.80489316
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.78625583
16Reticulocytopenia (HP:0001896)3.76411181
17Chromsome breakage (HP:0040012)3.58824068
18Dysmetric saccades (HP:0000641)3.58699654
19Aplasia involving forearm bones (HP:0009822)3.57404868
20Absent forearm bone (HP:0003953)3.57404868
21Absent thumb (HP:0009777)3.48916760
22Patellar aplasia (HP:0006443)3.45857550
23Neoplasm of the oral cavity (HP:0100649)3.44198028
24Rectovaginal fistula (HP:0000143)3.43702855
25Rectal fistula (HP:0100590)3.43702855
26Ependymoma (HP:0002888)3.39519962
27Bradycardia (HP:0001662)3.34423299
28Congenital stationary night blindness (HP:0007642)3.30135759
29Focal seizures (HP:0007359)3.24331362
30Atonic seizures (HP:0010819)3.23819018
31Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.23446847
32Abnormality of the labia minora (HP:0012880)3.19917417
33Abdominal situs inversus (HP:0003363)3.16183701
34Abnormality of abdominal situs (HP:0011620)3.16183701
35Selective tooth agenesis (HP:0001592)3.16158269
36Aplasia/hypoplasia of the humerus (HP:0006507)3.15077955
37Acute encephalopathy (HP:0006846)3.14940260
38Aplasia/Hypoplasia of the patella (HP:0006498)3.14033688
39Intestinal fistula (HP:0100819)3.11256262
40Febrile seizures (HP:0002373)3.10476196
41Vaginal fistula (HP:0004320)3.08905528
42Progressive inability to walk (HP:0002505)3.08792540
43Decreased electroretinogram (ERG) amplitude (HP:0000654)3.02309873
44Short middle phalanx of the 5th finger (HP:0004220)3.01769986
45Impulsivity (HP:0100710)3.00413446
46Acute necrotizing encephalopathy (HP:0006965)2.99114740
47Dialeptic seizures (HP:0011146)2.96204388
48Abnormality of the hepatic vasculature (HP:0006707)2.90179770
49Thrombocytosis (HP:0001894)2.90176207
50Pendular nystagmus (HP:0012043)2.88609245
51Ectopic kidney (HP:0000086)2.87331113
52Duplicated collecting system (HP:0000081)2.83020199
53Short humerus (HP:0005792)2.80629428
54Dysdiadochokinesis (HP:0002075)2.77622754
55Medulloblastoma (HP:0002885)2.76757827
56Amaurosis fugax (HP:0100576)2.68794949
57Focal motor seizures (HP:0011153)2.68779766
58Abnormal mitochondria in muscle tissue (HP:0008316)2.67505282
59Hyperacusis (HP:0010780)2.66665668
60Breast aplasia (HP:0100783)2.65819365
61Abnormal number of erythroid precursors (HP:0012131)2.61576469
62Stomatitis (HP:0010280)2.58763773
63Chest pain (HP:0100749)2.57430035
64Myelodysplasia (HP:0002863)2.55260403
65Hypothermia (HP:0002045)2.54708032
66Increased nuchal translucency (HP:0010880)2.51689473
67Supernumerary spleens (HP:0009799)2.48707846
68Fused cervical vertebrae (HP:0002949)2.48407405
69Rhabdomyosarcoma (HP:0002859)2.48271307
70Decreased central vision (HP:0007663)2.47513881
71Mitochondrial inheritance (HP:0001427)2.46362310
72Bony spicule pigmentary retinopathy (HP:0007737)2.46019840
73Hyperglycinemia (HP:0002154)2.44101877
74Hepatocellular necrosis (HP:0001404)2.43277650
75Absent rod-and cone-mediated responses on ERG (HP:0007688)2.42894730
76Abnormality of chromosome stability (HP:0003220)2.42195737
77Aplasia/Hypoplasia of the breasts (HP:0010311)2.39083449
78Colon cancer (HP:0003003)2.38442539
79Abnormal rod and cone electroretinograms (HP:0008323)2.37924110
80Abnormality of the renal collecting system (HP:0004742)2.37510162
81Abnormality of the diencephalon (HP:0010662)2.36640982
82Meckel diverticulum (HP:0002245)2.34630326
83Horseshoe kidney (HP:0000085)2.33347563
84Abnormality of male internal genitalia (HP:0000022)2.33261863
85Hypoplastic iliac wings (HP:0002866)2.32080898
86Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.31803542
87Short 1st metacarpal (HP:0010034)2.31803542
88Progressive macrocephaly (HP:0004481)2.29783114
89Abnormality of the ileum (HP:0001549)2.28168819
90Aplasia/Hypoplasia involving the musculature (HP:0001460)2.27973888
91Elfin facies (HP:0004428)2.26270880
92Severe visual impairment (HP:0001141)2.26264786
93Postural instability (HP:0002172)2.26229316
94Mutism (HP:0002300)2.25493719
95Synostosis involving the elbow (HP:0003938)2.25037938
96Humeroradial synostosis (HP:0003041)2.25037938
97Spastic diplegia (HP:0001264)2.24873046
98Attenuation of retinal blood vessels (HP:0007843)2.24163139
99Cortical dysplasia (HP:0002539)2.23904704
100Abnormality of the carotid arteries (HP:0005344)2.22993195
101Astrocytoma (HP:0009592)2.21817916
102Abnormality of the astrocytes (HP:0100707)2.21817916
103Abnormality of the preputium (HP:0100587)2.21761858
104Bone marrow hypocellularity (HP:0005528)2.21663419
105Abnormality of cells of the erythroid lineage (HP:0012130)2.21270308
106Urinary bladder sphincter dysfunction (HP:0002839)2.21027306
107Tracheoesophageal fistula (HP:0002575)2.19331361
108Sex reversal (HP:0012245)2.18059902
109Abnormal sex determination (HP:0012244)2.18059902
110Hepatic necrosis (HP:0002605)2.16174187
111Cutaneous melanoma (HP:0012056)2.15633337
112Long foot (HP:0001833)2.15126939
113Aplastic anemia (HP:0001915)2.14921715
114Impaired vibratory sensation (HP:0002495)2.13795347
115Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.13033307
116Vertebral hypoplasia (HP:0008417)2.13033307
117Optic disc pallor (HP:0000543)2.12639208
118Aplasia/Hypoplasia of the brainstem (HP:0007362)2.12604201
119Hypoplasia of the brainstem (HP:0002365)2.12604201
12011 pairs of ribs (HP:0000878)2.11951364
121Progressive microcephaly (HP:0000253)2.11866964
122Degeneration of anterior horn cells (HP:0002398)2.11644950
123Abnormality of the anterior horn cell (HP:0006802)2.11644950
124Microretrognathia (HP:0000308)2.11540524
125Missing ribs (HP:0000921)2.10072549
126Gonadotropin excess (HP:0000837)2.09720848
127Supraventricular tachycardia (HP:0004755)2.09249923
128Short 5th finger (HP:0009237)2.08746045
129Type II lissencephaly (HP:0007260)2.07693605
130Primary atrial arrhythmia (HP:0001692)2.07462813
131Impaired smooth pursuit (HP:0007772)2.06974866
132Anal stenosis (HP:0002025)2.06793864
133Cleft eyelid (HP:0000625)2.06760665
134Increased CSF lactate (HP:0002490)2.06218496
135Aplasia/Hypoplasia of the uvula (HP:0010293)2.06124958
136Optic nerve hypoplasia (HP:0000609)2.06089930
137Pallor (HP:0000980)2.04814117
138Concave nail (HP:0001598)2.04759866
139Facial hemangioma (HP:0000329)2.04337892
140Sloping forehead (HP:0000340)2.04292107
141Abnormality of pyrimidine metabolism (HP:0004353)2.03309974
142Basal cell carcinoma (HP:0002671)2.03242510
143Dyskinesia (HP:0100660)2.02099705
144Overriding aorta (HP:0002623)2.01253298
145Supraventricular arrhythmia (HP:0005115)2.00919191
146Pelvic girdle muscle weakness (HP:0003749)2.00253411
147Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.99866748
148Impaired proprioception (HP:0010831)1.99566813
149Hypoplasia of the radius (HP:0002984)1.99081433
150Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98595034
151Oral leukoplakia (HP:0002745)1.98225540
152Glioma (HP:0009733)1.97386229
153Overlapping toe (HP:0001845)1.96448478
154External ophthalmoplegia (HP:0000544)1.96246146
155Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.95253845
156Slow saccadic eye movements (HP:0000514)1.94553453
157Breech presentation (HP:0001623)1.94442721
158Abnormality of the 1st metacarpal (HP:0010009)1.93909900
159Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.93289507
160Prominent nose (HP:0000448)1.92820722
161Renovascular hypertension (HP:0100817)1.92005335
162Cerebral edema (HP:0002181)1.91897174
163Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91556133
164Abnormal protein N-linked glycosylation (HP:0012347)1.91556133
165Abnormal protein glycosylation (HP:0012346)1.91556133
166Abnormal glycosylation (HP:0012345)1.91556133
167Neoplasm of the pancreas (HP:0002894)1.91035904
168Triphalangeal thumb (HP:0001199)1.91008791
169Atresia of the external auditory canal (HP:0000413)1.90295095
170Macular degeneration (HP:0000608)1.89483065
171Hypophosphatemic rickets (HP:0004912)1.89341221
172Malignant gastrointestinal tract tumors (HP:0006749)1.88759243
173Gastrointestinal carcinoma (HP:0002672)1.88759243
174Short thumb (HP:0009778)1.88708824
175Macrocytic anemia (HP:0001972)1.87983864
176Rough bone trabeculation (HP:0100670)1.87830012
177Chronic obstructive pulmonary disease (HP:0006510)1.87176666
178Obstructive lung disease (HP:0006536)1.87176666
179Rib fusion (HP:0000902)1.85973797
180Failure to thrive in infancy (HP:0001531)1.85964155
181Abnormality of vision evoked potentials (HP:0000649)1.85424739
182Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.84675486
183Generalized aminoaciduria (HP:0002909)1.84179223
184Renal Fanconi syndrome (HP:0001994)1.83776985
185Palpebral edema (HP:0100540)1.83689094
186Constricted visual fields (HP:0001133)1.83173877
187Broad-based gait (HP:0002136)1.83080995
188Opisthotonus (HP:0002179)1.81308229
189Symphalangism affecting the phalanges of the hand (HP:0009773)1.80513480
190Cerebellar dysplasia (HP:0007033)1.80204537
191Abnormality of macular pigmentation (HP:0008002)1.79939631
192Atrial fibrillation (HP:0005110)1.79802811
193Decreased muscle mass (HP:0003199)1.77640945
194Polymicrogyria (HP:0002126)1.77135987
195Lipid accumulation in hepatocytes (HP:0006561)1.76398091
196Limb ataxia (HP:0002070)1.74971801

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK196.60432443
2ERBB34.28715219
3BMPR23.79425648
4OXSR13.72051744
5WEE13.58172248
6BUB13.25102832
7PLK43.19973049
8PIM23.01617590
9CDK122.85888767
10FRK2.85037977
11CDC72.77504449
12EPHA22.69404468
13SRPK12.62936889
14TTK2.42534114
15NEK92.40266305
16TNK22.40131726
17PINK12.34986020
18VRK22.33719279
19NEK22.28785979
20TAOK32.21888721
21EPHA32.21840026
22RPS6KB22.20443803
23MAP4K22.18851175
24PLK12.07612958
25DYRK31.94647585
26NEK11.87803077
27MARK11.84254475
28ATR1.79191023
29NUAK11.75691696
30TESK21.74496835
31KDR1.73348878
32YES11.68702455
33ADRBK21.67629911
34CDK71.61767175
35GRK11.61438141
36DYRK21.60969214
37TXK1.60387782
38TESK11.60028561
39MAP2K71.58071352
40PNCK1.56843974
41CHEK21.56033153
42PASK1.47062694
43EIF2AK11.46538830
44STK101.42250266
45MAPKAPK31.40795727
46PLK31.40345475
47STK41.32885124
48NME21.32504419
49TSSK61.31749540
50WNK41.30674999
51AURKB1.27309164
52TLK11.25161935
53SIK21.24356524
54ALK1.23274375
55CHEK11.23068044
56WNK11.22763279
57BCKDK1.15487367
58BMPR1B1.13660362
59PIK3CA1.11766774
60MAP3K81.11283998
61CDK41.09355443
62MAP3K41.08677749
63BLK1.07950413
64RPS6KA41.07148136
65PAK41.02029507
66AURKA0.99498935
67PIM10.98097522
68VRK10.96966630
69CDK60.96798012
70BRD40.95337491
71ZAK0.94720409
72EIF2AK30.93508966
73TEC0.93072388
74JAK30.92217186
75DAPK10.91637928
76LIMK10.91232596
77WNK30.89399448
78CDK20.87010886
79MAPK130.85737322
80PBK0.85675362
81MST40.85394090
82ATM0.83794002
83DYRK1A0.81717824
84CLK10.81478215
85PRKCQ0.81144738
86ABL20.80880949
87MAP4K10.80608833
88MKNK10.80501608
89AKT30.78891400
90ITK0.78450128
91MARK30.76260657
92MAP3K70.75908730
93TYK20.75042227
94ADRBK10.72254434
95PRKCI0.70445027
96CSNK1G20.70435927
97ACVR1B0.68974839
98PRKCG0.68731012
99CDK50.68181215
100MAP2K40.67153630
101CSK0.66405809
102CSNK2A20.65213262
103ABL10.65179900
104BTK0.64890290
105CSNK1G10.64486877
106SYK0.64242561
107TGFBR10.63536325
108EIF2AK20.62087637
109IRAK30.61377022
110MAP2K60.61126054
111EEF2K0.61107982
112INSRR0.58698414
113MUSK0.58010247
114PIK3CG0.57068788
115CDK10.56805295
116MAPK150.56721109
117MAP3K100.55888916
118PDK20.55829930
119MST1R0.55619952
120CSNK2A10.55592296
121GRK60.54958474
122CSNK1G30.54749434
123IKBKB0.54319164
124CSNK1A10.52587862
125BCR0.51790455
126MAP3K120.51493209
127CAMK2G0.50887597
128MAP3K50.50884272
129MINK10.49836508
130STK160.49022752
131CSNK1D0.48704477
132TAF10.48060143
133PRKCE0.46813531
134FES0.46546489
135MELK0.45688664
136CSF1R0.45262088
137PRKACA0.44505385
138FLT30.44086250
139TYRO30.43767075
140LCK0.43621215
141CDK30.43594879
142CSNK1A1L0.43503752
143MKNK20.43400264
144RIPK10.43374801
145STK30.43328549
146SIK30.43173842
147MTOR0.41889903
148STK110.41579641
149CDK150.41501181
150PRKAA10.40433989
151CHUK0.40291502
152IGF1R0.39863392
153CDK180.39435199
154KIT0.39351029
155PDK40.38788372
156PDK30.38788372
157CDK11A0.38123539
158PAK10.37507753
159LRRK20.37251729
160LYN0.36882271
161CDK90.36662914
162CAMK2A0.35190736
163BRSK20.35007426
164MAPKAPK50.34531043
165MAPK30.34397812
166PDK10.33233117
167PRKCA0.33056149
168MAPK140.31630910
169MAPKAPK20.31020105
170AKT20.30781845
171IRAK40.30204335
172PRKDC0.29972195
173MAP3K110.27419494
174CSNK1E0.25887258
175MATK0.25036944
176RPS6KA50.24375358
177IKBKE0.23251734

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.38244248
2DNA replication_Homo sapiens_hsa030305.13651685
3Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.84004148
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.75009042
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.51038962
6Homologous recombination_Homo sapiens_hsa034403.36247312
7Ribosome_Homo sapiens_hsa030103.30875034
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.24626602
9RNA polymerase_Homo sapiens_hsa030203.07523398
10One carbon pool by folate_Homo sapiens_hsa006703.07194748
11Nicotine addiction_Homo sapiens_hsa050333.01271013
12Nucleotide excision repair_Homo sapiens_hsa034202.92024156
13Spliceosome_Homo sapiens_hsa030402.90322934
14Base excision repair_Homo sapiens_hsa034102.86956887
15RNA transport_Homo sapiens_hsa030132.83721222
16Proteasome_Homo sapiens_hsa030502.61383610
17Butanoate metabolism_Homo sapiens_hsa006502.58308069
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.56283563
19Fanconi anemia pathway_Homo sapiens_hsa034602.38255985
20Non-homologous end-joining_Homo sapiens_hsa034502.36846385
21Olfactory transduction_Homo sapiens_hsa047402.25029241
22Pyrimidine metabolism_Homo sapiens_hsa002402.18134099
23Cell cycle_Homo sapiens_hsa041102.14207887
24Taste transduction_Homo sapiens_hsa047422.02355260
25Oxidative phosphorylation_Homo sapiens_hsa001902.00614080
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.95813636
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88762225
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.86645864
29Parkinsons disease_Homo sapiens_hsa050121.79673491
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77381479
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.62063683
32p53 signaling pathway_Homo sapiens_hsa041151.61814724
33RNA degradation_Homo sapiens_hsa030181.57595030
34Retinol metabolism_Homo sapiens_hsa008301.56752944
35mRNA surveillance pathway_Homo sapiens_hsa030151.51914151
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44892987
37GABAergic synapse_Homo sapiens_hsa047271.40991597
38Phototransduction_Homo sapiens_hsa047441.37083649
39Morphine addiction_Homo sapiens_hsa050321.36601527
40Caffeine metabolism_Homo sapiens_hsa002321.36333150
41Basal transcription factors_Homo sapiens_hsa030221.35729347
42Epstein-Barr virus infection_Homo sapiens_hsa051691.31903439
43Alzheimers disease_Homo sapiens_hsa050101.24228910
44Herpes simplex infection_Homo sapiens_hsa051681.20000365
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.19455168
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.19153171
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17739004
48Pentose phosphate pathway_Homo sapiens_hsa000301.17036722
49Propanoate metabolism_Homo sapiens_hsa006401.13606165
50Peroxisome_Homo sapiens_hsa041461.08925363
51N-Glycan biosynthesis_Homo sapiens_hsa005101.06726382
52Cardiac muscle contraction_Homo sapiens_hsa042601.03925290
53Ether lipid metabolism_Homo sapiens_hsa005651.03725423
54Purine metabolism_Homo sapiens_hsa002301.02724348
55Systemic lupus erythematosus_Homo sapiens_hsa053221.02420973
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02397434
57Linoleic acid metabolism_Homo sapiens_hsa005911.01460422
58Viral carcinogenesis_Homo sapiens_hsa052031.01064777
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00914646
60Tryptophan metabolism_Homo sapiens_hsa003800.99041095
61Glutamatergic synapse_Homo sapiens_hsa047240.97100153
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91399240
63Renin-angiotensin system_Homo sapiens_hsa046140.91186017
64Folate biosynthesis_Homo sapiens_hsa007900.90730747
65Antigen processing and presentation_Homo sapiens_hsa046120.83720878
66Type I diabetes mellitus_Homo sapiens_hsa049400.82796505
67Legionellosis_Homo sapiens_hsa051340.81658444
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80721782
69Selenocompound metabolism_Homo sapiens_hsa004500.80129603
70Biosynthesis of amino acids_Homo sapiens_hsa012300.79146307
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78401964
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77277490
73Circadian entrainment_Homo sapiens_hsa047130.75444364
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.74066274
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73792151
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73042340
77Salivary secretion_Homo sapiens_hsa049700.72248302
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72151233
79Measles_Homo sapiens_hsa051620.72027246
80ABC transporters_Homo sapiens_hsa020100.70066012
81Primary immunodeficiency_Homo sapiens_hsa053400.69471053
82HTLV-I infection_Homo sapiens_hsa051660.64708901
83Chemical carcinogenesis_Homo sapiens_hsa052040.64486914
84Melanoma_Homo sapiens_hsa052180.64142757
85Cocaine addiction_Homo sapiens_hsa050300.63688461
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.62376720
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.61481890
88Influenza A_Homo sapiens_hsa051640.60997150
89Rheumatoid arthritis_Homo sapiens_hsa053230.60525750
90Apoptosis_Homo sapiens_hsa042100.59352072
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59272460
92Metabolic pathways_Homo sapiens_hsa011000.58455126
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58440174
94Notch signaling pathway_Homo sapiens_hsa043300.57339777
95Other glycan degradation_Homo sapiens_hsa005110.55569757
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55117587
97Oocyte meiosis_Homo sapiens_hsa041140.54989627
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54789460
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54780091
100Chronic myeloid leukemia_Homo sapiens_hsa052200.54538263
101Glutathione metabolism_Homo sapiens_hsa004800.54352334
102Dopaminergic synapse_Homo sapiens_hsa047280.54184326
103Dorso-ventral axis formation_Homo sapiens_hsa043200.53079128
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52529744
105Small cell lung cancer_Homo sapiens_hsa052220.51242885
106MicroRNAs in cancer_Homo sapiens_hsa052060.50648473
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50338573
108Fat digestion and absorption_Homo sapiens_hsa049750.48940296
109Mineral absorption_Homo sapiens_hsa049780.47134091
110Ovarian steroidogenesis_Homo sapiens_hsa049130.46293440
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.45929476
112Viral myocarditis_Homo sapiens_hsa054160.45037381
113Regulation of autophagy_Homo sapiens_hsa041400.42996716
114Calcium signaling pathway_Homo sapiens_hsa040200.42541448
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42419894
116Hepatitis B_Homo sapiens_hsa051610.41620673
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41258588
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40684189
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40368228
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38827107
121B cell receptor signaling pathway_Homo sapiens_hsa046620.38436236
122Allograft rejection_Homo sapiens_hsa053300.37759851
123Sulfur relay system_Homo sapiens_hsa041220.36583949
124Axon guidance_Homo sapiens_hsa043600.36542809
125Thyroid cancer_Homo sapiens_hsa052160.36121978
126Fructose and mannose metabolism_Homo sapiens_hsa000510.35976254
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34730768
128Colorectal cancer_Homo sapiens_hsa052100.33982426
129Galactose metabolism_Homo sapiens_hsa000520.33947079
130Tyrosine metabolism_Homo sapiens_hsa003500.33823638
131Vitamin digestion and absorption_Homo sapiens_hsa049770.32885643
132Steroid biosynthesis_Homo sapiens_hsa001000.32416271
133Shigellosis_Homo sapiens_hsa051310.32394572
134Glycerolipid metabolism_Homo sapiens_hsa005610.30989078
135Acute myeloid leukemia_Homo sapiens_hsa052210.30853049
136Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30663644
137Hepatitis C_Homo sapiens_hsa051600.30354421
138Phagosome_Homo sapiens_hsa041450.29759755
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29174571
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.29025369
141Arachidonic acid metabolism_Homo sapiens_hsa005900.28559091
142Intestinal immune network for IgA production_Homo sapiens_hsa046720.28514297
143Huntingtons disease_Homo sapiens_hsa050160.28431433
144Fatty acid biosynthesis_Homo sapiens_hsa000610.28286574
145beta-Alanine metabolism_Homo sapiens_hsa004100.27138688
146alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26064779
147Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25668961
148Gastric acid secretion_Homo sapiens_hsa049710.25454452
149Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25117765
150Carbon metabolism_Homo sapiens_hsa012000.24704164
151Leishmaniasis_Homo sapiens_hsa051400.24377673
152Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22316380
153Toll-like receptor signaling pathway_Homo sapiens_hsa046200.21307070
154Asthma_Homo sapiens_hsa053100.21066380
155Alcoholism_Homo sapiens_hsa050340.20642940
156Hematopoietic cell lineage_Homo sapiens_hsa046400.19173263
157HIF-1 signaling pathway_Homo sapiens_hsa040660.18118482
158Leukocyte transendothelial migration_Homo sapiens_hsa046700.17914881
159Pathways in cancer_Homo sapiens_hsa052000.17541154
160Graft-versus-host disease_Homo sapiens_hsa053320.17228990
161Tuberculosis_Homo sapiens_hsa051520.16815092
162Bladder cancer_Homo sapiens_hsa052190.15105157
163TGF-beta signaling pathway_Homo sapiens_hsa043500.15085929
164T cell receptor signaling pathway_Homo sapiens_hsa046600.13851529
165Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13521016
166Autoimmune thyroid disease_Homo sapiens_hsa053200.12454982
167Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.11263457

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