SULT1C2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)6.97408701
2lysine metabolic process (GO:0006553)6.40487502
3lysine catabolic process (GO:0006554)6.40487502
4urate metabolic process (GO:0046415)6.38269755
5L-phenylalanine catabolic process (GO:0006559)6.24752743
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.24752743
7L-phenylalanine metabolic process (GO:0006558)6.11401899
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.11401899
9glyoxylate metabolic process (GO:0046487)6.03040093
10cysteine metabolic process (GO:0006534)5.95548862
11drug transport (GO:0015893)5.72086060
12behavioral response to nicotine (GO:0035095)5.51248466
13aromatic amino acid family catabolic process (GO:0009074)5.42400484
14aminoglycoside antibiotic metabolic process (GO:0030647)5.36505621
15drug catabolic process (GO:0042737)5.20218768
16sulfur amino acid catabolic process (GO:0000098)4.97851612
17exogenous drug catabolic process (GO:0042738)4.86571731
18organic cation transport (GO:0015695)4.85185788
19short-chain fatty acid metabolic process (GO:0046459)4.83509636
20valine metabolic process (GO:0006573)4.81780885
21cellular modified amino acid catabolic process (GO:0042219)4.81120485
22homocysteine metabolic process (GO:0050667)4.70292889
23tryptophan catabolic process (GO:0006569)4.69275736
24indole-containing compound catabolic process (GO:0042436)4.69275736
25indolalkylamine catabolic process (GO:0046218)4.69275736
26phosphate ion transport (GO:0006817)4.67410548
27branched-chain amino acid metabolic process (GO:0009081)4.64307665
28aspartate family amino acid catabolic process (GO:0009068)4.55001537
29digestion (GO:0007586)4.53884816
30tryptophan metabolic process (GO:0006568)4.52818911
31serine family amino acid catabolic process (GO:0009071)4.44925576
32glutathione derivative metabolic process (GO:1901685)4.44054154
33glutathione derivative biosynthetic process (GO:1901687)4.44054154
34parturition (GO:0007567)4.42588433
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.39120302
36gamma-aminobutyric acid transport (GO:0015812)4.33002069
37detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.32468690
38tricarboxylic acid metabolic process (GO:0072350)4.31794557
39response to mercury ion (GO:0046689)4.29473310
40branched-chain amino acid catabolic process (GO:0009083)4.24987561
41flavonoid metabolic process (GO:0009812)4.22992537
42quaternary ammonium group transport (GO:0015697)4.19356817
43ovulation cycle (GO:0042698)4.18538891
44cellular ketone body metabolic process (GO:0046950)4.17380240
45amino-acid betaine metabolic process (GO:0006577)4.12613834
46cellular glucuronidation (GO:0052695)4.06659290
47positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.05012401
48cellular amino acid catabolic process (GO:0009063)4.04829920
49kynurenine metabolic process (GO:0070189)4.03508678
50negative regulation of digestive system process (GO:0060457)4.01695332
51alpha-amino acid catabolic process (GO:1901606)3.99830491
52aromatic amino acid family metabolic process (GO:0009072)3.98088299
53uronic acid metabolic process (GO:0006063)3.97477414
54glucuronate metabolic process (GO:0019585)3.97477414
55serine family amino acid metabolic process (GO:0009069)3.96157979
562-oxoglutarate metabolic process (GO:0006103)3.95964126
57intestinal cholesterol absorption (GO:0030299)3.92517569
58fatty acid beta-oxidation (GO:0006635)3.87551719
59fatty acid oxidation (GO:0019395)3.86128226
60phosphate ion transmembrane transport (GO:0035435)3.82853955
61response to pheromone (GO:0019236)3.80948182
62intestinal absorption (GO:0050892)3.80234956
63lipid oxidation (GO:0034440)3.77774989
64fucose catabolic process (GO:0019317)3.76236510
65L-fucose metabolic process (GO:0042354)3.76236510
66L-fucose catabolic process (GO:0042355)3.76236510
67coenzyme catabolic process (GO:0009109)3.75902873
68glutathione metabolic process (GO:0006749)3.72021893
69drug metabolic process (GO:0017144)3.66263397
70carboxylic acid catabolic process (GO:0046395)3.63626182
71organic acid catabolic process (GO:0016054)3.63626182
72nonribosomal peptide biosynthetic process (GO:0019184)3.62994602
73bile acid biosynthetic process (GO:0006699)3.62061801
74glutamate metabolic process (GO:0006536)3.61404681
75ketone body metabolic process (GO:1902224)3.57863134
76proline metabolic process (GO:0006560)3.57403274
77benzene-containing compound metabolic process (GO:0042537)3.56513081
78fatty acid catabolic process (GO:0009062)3.53598715
79renal absorption (GO:0070293)3.53313880
80monocarboxylic acid catabolic process (GO:0072329)3.45995018
81acetyl-CoA metabolic process (GO:0006084)3.43938926
82glutathione biosynthetic process (GO:0006750)3.42860541
83serine family amino acid biosynthetic process (GO:0009070)3.41248940
84regulation of cholesterol homeostasis (GO:2000188)3.39244525
85indolalkylamine metabolic process (GO:0006586)3.38789335
86excretion (GO:0007588)3.37580244
87vitamin transport (GO:0051180)3.36916502
88protein retention in ER lumen (GO:0006621)3.36715176
89carnitine transport (GO:0015879)3.32427599
90amino-acid betaine transport (GO:0015838)3.32427599
91bile acid metabolic process (GO:0008206)3.28669590
92fructose metabolic process (GO:0006000)3.27678640
93nephron epithelium morphogenesis (GO:0072088)3.27219914
94nephron tubule morphogenesis (GO:0072078)3.27219914
95carnitine metabolic process (GO:0009437)3.25555396
96ethanol oxidation (GO:0006069)3.25231482
97negative regulation of cholesterol transport (GO:0032375)3.24778610
98negative regulation of sterol transport (GO:0032372)3.24778610
99alpha-linolenic acid metabolic process (GO:0036109)3.24575326
100cobalamin metabolic process (GO:0009235)3.24076313
101biotin metabolic process (GO:0006768)3.23571983
102maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.23213191
1034-hydroxyproline metabolic process (GO:0019471)3.18586076
104indole-containing compound metabolic process (GO:0042430)3.17964886
105tyrosine metabolic process (GO:0006570)3.17220158
106xenobiotic catabolic process (GO:0042178)3.14817288
107small molecule catabolic process (GO:0044282)3.14087797
108maintenance of gastrointestinal epithelium (GO:0030277)3.13458266
109reflex (GO:0060004)3.13204344
110vitamin D metabolic process (GO:0042359)3.12292993
111amine catabolic process (GO:0009310)3.09840404
112cellular biogenic amine catabolic process (GO:0042402)3.09840404
113aldehyde catabolic process (GO:0046185)3.07136891
114urea cycle (GO:0000050)3.06604006
115serotonin metabolic process (GO:0042428)3.05349804
116primary amino compound metabolic process (GO:1901160)3.03408805
117neuronal action potential (GO:0019228)3.02488923
118positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.95185084
119sequestering of actin monomers (GO:0042989)2.93250487
120neuronal stem cell maintenance (GO:0097150)2.90417137
121positive regulation of fatty acid oxidation (GO:0046321)2.89050602
122basic amino acid transport (GO:0015802)2.87762837
123detection of mechanical stimulus involved in sensory perception (GO:0050974)2.86765127
124renal tubule morphogenesis (GO:0061333)2.84778605
125neuron fate determination (GO:0048664)2.81664310
126regulation of glucokinase activity (GO:0033131)2.80618759
127regulation of hexokinase activity (GO:1903299)2.80618759
128epithelial cilium movement (GO:0003351)2.78375759
129phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200)2.76543623
130platelet dense granule organization (GO:0060155)2.73831099
131inner ear receptor stereocilium organization (GO:0060122)2.70883908
132NAD biosynthetic process (GO:0009435)2.70012384
133sulfate transmembrane transport (GO:1902358)2.67700229
134synaptic transmission, cholinergic (GO:0007271)2.67062066
135phasic smooth muscle contraction (GO:0014821)2.66520976
136cochlea development (GO:0090102)2.63669821
137sodium-independent organic anion transport (GO:0043252)2.63363088
138detection of light stimulus involved in sensory perception (GO:0050962)2.63184980
139detection of light stimulus involved in visual perception (GO:0050908)2.63184980
140* sulfation (GO:0051923)2.62338143
141spinal cord motor neuron differentiation (GO:0021522)2.62255552
142somite development (GO:0061053)2.61949110
143negative regulation of telomere maintenance (GO:0032205)2.60145873
144auditory receptor cell stereocilium organization (GO:0060088)2.59980129
145regulation of heat generation (GO:0031650)2.59181206
146negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.58371479
147positive regulation of vascular permeability (GO:0043117)2.57698192
148epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.56319900
149hindbrain development (GO:0030902)2.54801269
150positive regulation of fatty acid transport (GO:2000193)2.54666838
151regulation of inositol phosphate biosynthetic process (GO:0010919)2.54331715
152somite rostral/caudal axis specification (GO:0032525)2.53471080
153urinary tract smooth muscle contraction (GO:0014848)2.53398049
154high-density lipoprotein particle remodeling (GO:0034375)2.53343950
155cilium morphogenesis (GO:0060271)2.52775276
156nonmotile primary cilium assembly (GO:0035058)2.52427812
157behavioral response to ethanol (GO:0048149)2.52383845
158negative regulation of systemic arterial blood pressure (GO:0003085)2.51647097
159protein-cofactor linkage (GO:0018065)2.51191293
160retinal cone cell development (GO:0046549)2.50126513
161G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49486102
162negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45740387
163reciprocal meiotic recombination (GO:0007131)2.44720321
164reciprocal DNA recombination (GO:0035825)2.44720321
165sulfate transport (GO:0008272)2.43812254
166cell morphogenesis involved in neuron differentiation (GO:0048667)2.43789871
167embryonic axis specification (GO:0000578)2.41809534
168establishment of protein localization to mitochondrial membrane (GO:0090151)2.41330976
169mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.39972306
170ATP synthesis coupled proton transport (GO:0015986)2.39553551
171energy coupled proton transport, down electrochemical gradient (GO:0015985)2.39553551
172negative regulation of reactive oxygen species metabolic process (GO:2000378)2.39550364
173regulation of action potential (GO:0098900)2.39504979
174positive regulation of cAMP-mediated signaling (GO:0043950)2.38544620
175seminiferous tubule development (GO:0072520)2.36772797
176replicative senescence (GO:0090399)2.35685035
177regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.33753259
178cilium organization (GO:0044782)2.32510702
179cilium movement (GO:0003341)2.31969721
180piRNA metabolic process (GO:0034587)2.31817110
181regulation of energy homeostasis (GO:2000505)2.31489772
182kidney morphogenesis (GO:0060993)2.30109110
183left/right axis specification (GO:0070986)2.29937566
184central nervous system myelination (GO:0022010)2.27965294
185axon ensheathment in central nervous system (GO:0032291)2.27965294
186potassium ion export (GO:0071435)2.27503653

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.31859097
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.31220163
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.58161915
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.01623087
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.19797500
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.90880723
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.81139899
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.48617011
9ZNF274_21170338_ChIP-Seq_K562_Hela3.46847687
10GBX2_23144817_ChIP-Seq_PC3_Human3.24209769
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.08858666
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.01801918
13* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.00735397
14EZH2_22144423_ChIP-Seq_EOC_Human2.98003202
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.93347720
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.75656056
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.68025900
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47585099
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.43985769
20IGF1R_20145208_ChIP-Seq_DFB_Human2.37136690
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24958114
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23740171
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19993411
24TAF15_26573619_Chip-Seq_HEK293_Human2.18184707
25* GATA4_25053715_ChIP-Seq_YYC3_Human2.16668706
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.03616947
27ESR2_21235772_ChIP-Seq_MCF-7_Human2.03038589
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97547095
29P300_19829295_ChIP-Seq_ESCs_Human1.97421338
30AR_21572438_ChIP-Seq_LNCaP_Human1.88855392
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.83980224
32CDX2_20551321_ChIP-Seq_CACO-2_Human1.80631421
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78401708
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76163543
35ER_23166858_ChIP-Seq_MCF-7_Human1.75958219
36TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.74572345
37FOXA2_19822575_ChIP-Seq_HepG2_Human1.74240838
38FUS_26573619_Chip-Seq_HEK293_Human1.73850797
39EWS_26573619_Chip-Seq_HEK293_Human1.71313302
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.69680104
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64472212
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60219820
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.60219820
44GATA6_25053715_ChIP-Seq_YYC3_Human1.60052069
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59705257
46* BCAT_22108803_ChIP-Seq_LS180_Human1.58431510
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.57993623
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57002147
49CLOCK_20551151_ChIP-Seq_293T_Human1.56225385
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56172566
51AR_25329375_ChIP-Seq_VCAP_Human1.54885903
52STAT3_23295773_ChIP-Seq_U87_Human1.53431216
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.52636723
54* HNF4A_19822575_ChIP-Seq_HepG2_Human1.51036549
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50351714
56TP53_16413492_ChIP-PET_HCT116_Human1.49559938
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48727858
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48577082
59SOX2_20726797_ChIP-Seq_SW620_Human1.47741918
60ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.46100693
61EGR1_19032775_ChIP-ChIP_M12_Human1.43425990
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43076739
63AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.42602585
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41882644
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41371787
66TCF4_23295773_ChIP-Seq_U87_Human1.41252781
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39781161
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38500447
69SMAD4_21799915_ChIP-Seq_A2780_Human1.38165129
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37617560
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35458502
72SOX2_19829295_ChIP-Seq_ESCs_Human1.33611047
73NANOG_19829295_ChIP-Seq_ESCs_Human1.33611047
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33100392
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32824791
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32728232
77* RXR_22108803_ChIP-Seq_LS180_Human1.31711294
78CBP_20019798_ChIP-Seq_JUKART_Human1.31679836
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31679836
80SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28570554
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28393950
82FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28196417
83REST_21632747_ChIP-Seq_MESCs_Mouse1.25114083
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25010722
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24283028
86EED_16625203_ChIP-ChIP_MESCs_Mouse1.23919338
87GATA1_22025678_ChIP-Seq_K562_Human1.23859650
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20989679
89* TCF4_22108803_ChIP-Seq_LS180_Human1.20379071
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20089819
91FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.19913770
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.19639713
93SMAD4_21741376_ChIP-Seq_EPCs_Human1.18174664
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.17590229
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17590229
96ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16198171
97TRIM28_21343339_ChIP-Seq_HEK293_Human1.15797164
98RUNX2_22187159_ChIP-Seq_PCA_Human1.15248595
99PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14982753
100* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14840581
101GATA3_21878914_ChIP-Seq_MCF-7_Human1.14579192
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.14378295
103IRF1_19129219_ChIP-ChIP_H3396_Human1.14100906
104ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12862123
105HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12788397
106DROSHA_22980978_ChIP-Seq_HELA_Human1.12523076
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.12351700
108BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.11779378
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11696488
110RNF2_27304074_Chip-Seq_NSC_Mouse1.11219596
111FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11194157
112EZH2_27294783_Chip-Seq_NPCs_Mouse1.10751951
113LXR_22292898_ChIP-Seq_THP-1_Human1.10339296
114JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10153424
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10022309
116FOXO3_23340844_ChIP-Seq_DLD1_Human1.08542012
117EZH2_27304074_Chip-Seq_ESCs_Mouse1.08154151
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08110143
119SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07962769
120NOTCH1_21737748_ChIP-Seq_TLL_Human1.07183202
121VDR_22108803_ChIP-Seq_LS180_Human1.06909840
122TP53_22573176_ChIP-Seq_HFKS_Human1.06600982
123HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06580224
124TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05498843
125ARNT_22903824_ChIP-Seq_MCF-7_Human1.05135699
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04998215
127P53_22387025_ChIP-Seq_ESCs_Mouse1.04345669
128SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03318122
129STAT3_18555785_Chip-Seq_ESCs_Mouse1.02908968
130FLI1_21867929_ChIP-Seq_TH2_Mouse1.02624554
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02008520
132SOX2_21211035_ChIP-Seq_LN229_Gbm1.01977248
133CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01505768
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01359531
135GATA3_24758297_ChIP-Seq_MCF-7_Human1.01348681
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.98858844
137TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98819086
138RNF2_27304074_Chip-Seq_ESCs_Mouse0.98774106
139FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98663346
140NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98039983
141TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97209168
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96864254
143BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95158272
144CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95127619
145RACK7_27058665_Chip-Seq_MCF-7_Human0.94946091
146RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89147488
147ESR1_20079471_ChIP-ChIP_T-47D_Human0.88115781
148NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87940307
149NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87940307
150* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86196495
151ERG_21242973_ChIP-ChIP_JURKAT_Human0.84055271
152SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83389941
153PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82238122
154CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81976677
155* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81570367
156AR_20517297_ChIP-Seq_VCAP_Human0.81031337
157MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.80371032
158P63_26484246_Chip-Seq_KERATINOCYTES_Human0.76539764
159ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.75842066
160* CDX2_22108803_ChIP-Seq_LS180_Human0.73903242
161SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73511049
162KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.73507354
163CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.71948135
164PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.71630856
165CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71568558
166ZNF217_24962896_ChIP-Seq_MCF-7_Human0.69818445
167EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.69517478
168TBX20_22328084_ChIP-Seq_HEART_Mouse0.68603432
169TBX20_22080862_ChIP-Seq_HEART_Mouse0.68603432
170STAT3_1855785_ChIP-Seq_MESCs_Mouse0.68543860
171MYC_19915707_ChIP-ChIP_AK7_Human0.67683803
172CEBPB_22108803_ChIP-Seq_LS180_Human0.67360767
173Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66779774
174SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66509405
175ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.65899095
176AHR_22903824_ChIP-Seq_MCF-7_Human0.65865190
177SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.65657831
178P53_21459846_ChIP-Seq_SAOS-2_Human0.65387641
179ERG_20517297_ChIP-Seq_VCAP_Human0.65375360
180ESET_19884257_ChIP-Seq_ESCs_Mouse0.64327458
181* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.63804639
182GATA2_19941826_ChIP-Seq_K562_Human0.63787528
183GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.63012892
184RARA_24833708_ChIP-Seq_LIVER_Mouse0.62732155
185SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.62595483
186RXRA_24833708_ChIP-Seq_LIVER_Mouse0.61979282
187ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.61414014
188SRY_22984422_ChIP-ChIP_TESTIS_Rat0.61202013
189RUNX1_27514584_Chip-Seq_MCF-7_Human0.60755039
190PIAS1_25552417_ChIP-Seq_VCAP_Human0.60502340
191KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.59691563
192* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.59527550

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color7.16550450
2MP0005360_urolithiasis6.29019244
3MP0002139_abnormal_hepatobiliary_system6.02951864
4MP0008004_abnormal_stomach_pH5.70086278
5MP0005365_abnormal_bile_salt4.85475150
6MP0005085_abnormal_gallbladder_physiolo4.48098463
7MP0005171_absent_coat_pigmentation4.15559685
8MP0001666_abnormal_nutrient_absorption3.82116317
9MP0004043_abnormal_pH_regulation3.74488567
10MP0008875_abnormal_xenobiotic_pharmacok3.73596709
11MP0003806_abnormal_nucleotide_metabolis3.50089716
12MP0005332_abnormal_amino_acid3.47006279
13MP0003195_calcinosis3.19357995
14MP0005083_abnormal_biliary_tract3.19112274
15MP0004019_abnormal_vitamin_homeostasis3.17530028
16MP0005646_abnormal_pituitary_gland3.02846622
17MP0002138_abnormal_hepatobiliary_system2.93972009
18MP0003252_abnormal_bile_duct2.91653860
19MP0002653_abnormal_ependyma_morphology2.87312638
20MP0009643_abnormal_urine_homeostasis2.71254042
21MP0003646_muscle_fatigue2.63754167
22MP0003868_abnormal_feces_composition2.37773737
23MP0000569_abnormal_digit_pigmentation2.26424223
24MP0001664_abnormal_digestion2.23630628
25MP0005636_abnormal_mineral_homeostasis2.22471002
26MP0000372_irregular_coat_pigmentation2.15228919
27MP0001765_abnormal_ion_homeostasis2.08333351
28MP0002938_white_spotting2.01690540
29MP0003890_abnormal_embryonic-extraembry1.97721741
30MP0010329_abnormal_lipoprotein_level1.97499264
31MP0005551_abnormal_eye_electrophysiolog1.97189634
32MP0001756_abnormal_urination1.96165491
33MP0009046_muscle_twitch1.84397895
34MP0005084_abnormal_gallbladder_morpholo1.82756491
35MP0005187_abnormal_penis_morphology1.82224614
36MP0002876_abnormal_thyroid_physiology1.78242737
37MP0001873_stomach_inflammation1.77680574
38MP0005220_abnormal_exocrine_pancreas1.74734490
39MP0001986_abnormal_taste_sensitivity1.74473113
40MP0002736_abnormal_nociception_after1.72123806
41MP0005174_abnormal_tail_pigmentation1.66754205
42MP0002102_abnormal_ear_morphology1.66199129
43MP0003186_abnormal_redox_activity1.63477590
44MP0004133_heterotaxia1.62540157
45MP0002118_abnormal_lipid_homeostasis1.61498878
46MP0010234_abnormal_vibrissa_follicle1.57779658
47MP0001968_abnormal_touch/_nociception1.56601157
48MP0000631_abnormal_neuroendocrine_gland1.55393999
49MP0002136_abnormal_kidney_physiology1.53393781
50MP0001501_abnormal_sleep_pattern1.53096262
51MP0004142_abnormal_muscle_tone1.51592527
52MP0002277_abnormal_respiratory_mucosa1.49690506
53MP0005058_abnormal_lysosome_morphology1.49667855
54MP0001324_abnormal_eye_pigmentation1.47765519
55MP0009745_abnormal_behavioral_response1.46001894
56MP0005319_abnormal_enzyme/_coenzyme1.44331910
57MP0001486_abnormal_startle_reflex1.43954487
58MP0004264_abnormal_extraembryonic_tissu1.42340275
59MP0002733_abnormal_thermal_nociception1.41969520
60MP0005253_abnormal_eye_physiology1.37815728
61MP0003191_abnormal_cellular_cholesterol1.35307523
62MP0000470_abnormal_stomach_morphology1.34072613
63MP0005584_abnormal_enzyme/coenzyme_acti1.31487297
64MP0008872_abnormal_physiological_respon1.31358896
65MP0002064_seizures1.30616329
66MP0000609_abnormal_liver_physiology1.29879280
67MP0002735_abnormal_chemical_nociception1.27590495
68MP0001970_abnormal_pain_threshold1.25894332
69MP0002638_abnormal_pupillary_reflex1.25790037
70MP0002095_abnormal_skin_pigmentation1.24500813
71MP0002272_abnormal_nervous_system1.24022074
72MP0004742_abnormal_vestibular_system1.21605864
73MP0002067_abnormal_sensory_capabilities1.19933037
74MP0005451_abnormal_body_composition1.18546422
75MP0003315_abnormal_perineum_morphology1.15717706
76MP0002822_catalepsy1.14924934
77MP0001529_abnormal_vocalization1.13408250
78MP0000026_abnormal_inner_ear1.12311955
79MP0001764_abnormal_homeostasis1.10032123
80MP0002572_abnormal_emotion/affect_behav1.09576543
81MP0000538_abnormal_urinary_bladder1.08912499
82MP0004924_abnormal_behavior1.06797989
83MP0005386_behavior/neurological_phenoty1.06797989
84MP0002078_abnormal_glucose_homeostasis1.03969204
85MP0005195_abnormal_posterior_eye1.00998714
86MP0001905_abnormal_dopamine_level1.00693046
87MP0006072_abnormal_retinal_apoptosis0.99418635
88MP0000427_abnormal_hair_cycle0.99338162
89MP0006036_abnormal_mitochondrial_physio0.98275005
90MP0001919_abnormal_reproductive_system0.97269298
91MP0003959_abnormal_lean_body0.97012881
92MP0005645_abnormal_hypothalamus_physiol0.95955902
93MP0003011_delayed_dark_adaptation0.95260607
94MP0001663_abnormal_digestive_system0.93937519
95MP0009840_abnormal_foam_cell0.93768897
96MP0005389_reproductive_system_phenotype0.93014476
97MP0005408_hypopigmentation0.92382510
98MP0008877_abnormal_DNA_methylation0.91879368
99MP0000566_synostosis0.90509142
100MP0001944_abnormal_pancreas_morphology0.89963602
101MP0002557_abnormal_social/conspecific_i0.89176164
102MP0003300_gastrointestinal_ulcer0.89131957
103MP0009642_abnormal_blood_homeostasis0.88865404
104MP0005377_hearing/vestibular/ear_phenot0.87656143
105MP0003878_abnormal_ear_physiology0.87656143
106MP0005535_abnormal_body_temperature0.87414540
107MP0002928_abnormal_bile_duct0.87224469
108MP0002693_abnormal_pancreas_physiology0.86891239
109MP0000371_diluted_coat_color0.85945732
110MP0008961_abnormal_basal_metabolism0.85882692
111MP0005165_increased_susceptibility_to0.85648361
112MP0000383_abnormal_hair_follicle0.83856806
113MP0003953_abnormal_hormone_level0.82371818
114MP0002229_neurodegeneration0.82316517
115MP0001963_abnormal_hearing_physiology0.80720146
116MP0000598_abnormal_liver_morphology0.79636914
117MP0005381_digestive/alimentary_phenotyp0.78982863
118MP0000778_abnormal_nervous_system0.77278369
119MP0003638_abnormal_response/metabolism_0.76516179
120MP0003283_abnormal_digestive_organ0.76304107
121MP0002896_abnormal_bone_mineralization0.76107883
122MP0003632_abnormal_nervous_system0.74682443
123MP0002751_abnormal_autonomic_nervous0.72354437
124MP0008995_early_reproductive_senescence0.72206896
125MP0001502_abnormal_circadian_rhythm0.71464061
126MP0001661_extended_life_span0.71116089
127MP0003705_abnormal_hypodermis_morpholog0.70419008
128MP0006276_abnormal_autonomic_nervous0.70058190
129MP0005167_abnormal_blood-brain_barrier0.69828711
130MP0004145_abnormal_muscle_electrophysio0.68778626
131MP0010386_abnormal_urinary_bladder0.68549656
132MP0000230_abnormal_systemic_arterial0.67817856
133MP0002282_abnormal_trachea_morphology0.66720684
134MP0002752_abnormal_somatic_nervous0.66304830
135MP0008469_abnormal_protein_level0.64927793
136MP0005666_abnormal_adipose_tissue0.64142906
137MP0002168_other_aberrant_phenotype0.63743313
138MP0005391_vision/eye_phenotype0.63005493
139MP0004215_abnormal_myocardial_fiber0.62757150
140MP0002160_abnormal_reproductive_system0.62562482
141MP0004130_abnormal_muscle_cell0.61226201
142MP0005670_abnormal_white_adipose0.60691543
143MP0002909_abnormal_adrenal_gland0.60555392
144MP0002837_dystrophic_cardiac_calcinosis0.60551722
145MP0001958_emphysema0.57862886
146MP0009780_abnormal_chondrocyte_physiolo0.57296685
147MP0002135_abnormal_kidney_morphology0.56817712
148MP0009764_decreased_sensitivity_to0.56628729
149MP0005448_abnormal_energy_balance0.56238576
150MP0004885_abnormal_endolymph0.56170326
151MP0002796_impaired_skin_barrier0.54036098
152MP0005266_abnormal_metabolism0.49650887
153MP0002254_reproductive_system_inflammat0.46368677
154MP0005334_abnormal_fat_pad0.45345082
155MP0009765_abnormal_xenobiotic_induced0.43603260
156MP0009384_cardiac_valve_regurgitation0.42672281
157MP0002098_abnormal_vibrissa_morphology0.42371900
158MP0005376_homeostasis/metabolism_phenot0.41927833
159MP0003172_abnormal_lysosome_physiology0.41389592
160MP0000477_abnormal_intestine_morphology0.40814073
161MP0002971_abnormal_brown_adipose0.40021361
162MP0002069_abnormal_eating/drinking_beha0.39014935
163MP0005375_adipose_tissue_phenotype0.37799175
164MP0006035_abnormal_mitochondrial_morpho0.36859439
165MP0005395_other_phenotype0.36124038
166MP0001485_abnormal_pinna_reflex0.35722943
167MP0003879_abnormal_hair_cell0.35622968
168MP0001845_abnormal_inflammatory_respons0.35230288
169MP0003724_increased_susceptibility_to0.35026617
170MP0002877_abnormal_melanocyte_morpholog0.34093568
171MP0000678_abnormal_parathyroid_gland0.34012320
172MP0004147_increased_porphyrin_level0.33608895

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)6.74505687
2Metabolic alkalosis (HP:0200114)5.09128517
3Hyperactive renin-angiotensin system (HP:0000841)4.98446471
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.88027673
5Hypokalemic alkalosis (HP:0001949)4.84532352
6Increased circulating renin level (HP:0000848)4.77041716
7Hyperventilation (HP:0002883)4.66675064
8Abnormality of chloride homeostasis (HP:0011422)4.61382922
9Proximal tubulopathy (HP:0000114)4.57773663
10Hyperuricemia (HP:0002149)4.56413117
11Increased purine levels (HP:0004368)4.56413117
12Hyperglycinuria (HP:0003108)4.56069963
13Abnormality of purine metabolism (HP:0004352)4.55232128
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.34884089
15Ketoacidosis (HP:0001993)4.28773583
16Hypomagnesemia (HP:0002917)4.28331008
17Pancreatic cysts (HP:0001737)4.13599287
18Abnormality of renal excretion (HP:0011036)4.12561789
19Ketosis (HP:0001946)4.10105030
20Polyuria (HP:0000103)4.09323298
21True hermaphroditism (HP:0010459)3.98881916
22Abnormal urine output (HP:0012590)3.93577593
23Alkalosis (HP:0001948)3.92961379
24Generalized aminoaciduria (HP:0002909)3.89544297
25Congenital stationary night blindness (HP:0007642)3.88026852
26Abnormality of serine family amino acid metabolism (HP:0010894)3.83291790
27Abnormality of glycine metabolism (HP:0010895)3.83291790
28Large for gestational age (HP:0001520)3.82250155
29Intrahepatic cholestasis (HP:0001406)3.79483064
30Abnormality of midbrain morphology (HP:0002418)3.75553968
31Molar tooth sign on MRI (HP:0002419)3.75553968
32Abnormality of magnesium homeostasis (HP:0004921)3.64903456
33Abnormality of nucleobase metabolism (HP:0010932)3.61301727
34Abnormality of monocarboxylic acid metabolism (HP:0010996)3.57084031
35Renal salt wasting (HP:0000127)3.53550345
36Hyperglycinemia (HP:0002154)3.43959312
37Pancreatic fibrosis (HP:0100732)3.43509597
38Abnormality of urine glucose concentration (HP:0011016)3.43326568
39Glycosuria (HP:0003076)3.43326568
40Chronic hepatic failure (HP:0100626)3.42527454
41Tubular atrophy (HP:0000092)3.41393593
42Hypoglycemic coma (HP:0001325)3.41328848
43Hyperammonemia (HP:0001987)3.41080806
44Abnormality of renin-angiotensin system (HP:0000847)3.40226520
45Abnormality of fatty-acid metabolism (HP:0004359)3.28865232
46Type II lissencephaly (HP:0007260)3.27176662
47Abnormality of aspartate family amino acid metabolism (HP:0010899)3.20568289
48Hyperaldosteronism (HP:0000859)3.20222607
49Nephronophthisis (HP:0000090)3.16967351
50Progressive cerebellar ataxia (HP:0002073)3.16304875
51Abnormal drinking behavior (HP:0030082)3.14185854
52Polydipsia (HP:0001959)3.14185854
53Abnormality of the renal medulla (HP:0100957)3.11767331
54Pheochromocytoma (HP:0002666)3.10083768
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.07365076
56Abnormality of alanine metabolism (HP:0010916)3.07365076
57Hyperalaninemia (HP:0003348)3.07365076
58Xanthomatosis (HP:0000991)3.06708542
59Abnormality of sulfur amino acid metabolism (HP:0004339)3.05064980
60Neuroendocrine neoplasm (HP:0100634)3.04012268
61Vascular calcification (HP:0004934)3.02223290
62Malnutrition (HP:0004395)2.98025627
63Congenital, generalized hypertrichosis (HP:0004540)2.96359628
64Abnormality of the renal cortex (HP:0011035)2.95341565
65Tetany (HP:0001281)2.86533834
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.86472388
67Dicarboxylic aciduria (HP:0003215)2.86472388
68Delayed CNS myelination (HP:0002188)2.84930361
69Attenuation of retinal blood vessels (HP:0007843)2.78781172
70Hypokalemia (HP:0002900)2.75806060
71Fat malabsorption (HP:0002630)2.73012367
72Vacuolated lymphocytes (HP:0001922)2.72068151
73Lethargy (HP:0001254)2.70532586
74Hyperphosphaturia (HP:0003109)2.70241541
75Furrowed tongue (HP:0000221)2.70120061
76Metabolic acidosis (HP:0001942)2.69168064
77Gaze-evoked nystagmus (HP:0000640)2.67835304
78Abnormal tarsal ossification (HP:0008369)2.67517000
79Cardiovascular calcification (HP:0011915)2.66833373
80Cystic liver disease (HP:0006706)2.63306003
81Conjugated hyperbilirubinemia (HP:0002908)2.63104818
82Decreased central vision (HP:0007663)2.62427177
83Late onset (HP:0003584)2.62349888
84Renal tubular acidosis (HP:0001947)2.59267153
85Hydroxyprolinuria (HP:0003080)2.59130062
86Abnormality of proline metabolism (HP:0010907)2.59130062
87Concave nail (HP:0001598)2.56755882
88Deep venous thrombosis (HP:0002625)2.55747745
89Optic nerve hypoplasia (HP:0000609)2.50533373
90Vomiting (HP:0002013)2.50188321
91Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.49731590
92Abnormal urine phosphate concentration (HP:0012599)2.49691444
93Hypercalciuria (HP:0002150)2.49017593
94Rickets (HP:0002748)2.47214860
95Hypophosphatemia (HP:0002148)2.45637031
96Nephrolithiasis (HP:0000787)2.41879390
97Inability to walk (HP:0002540)2.39893693
98Abnormality of potassium homeostasis (HP:0011042)2.39657827
99Enlarged kidneys (HP:0000105)2.36651226
100Sclerocornea (HP:0000647)2.35885609
101Increased corneal curvature (HP:0100692)2.35135043
102Keratoconus (HP:0000563)2.35135043
103Aplasia/Hypoplasia of the fovea (HP:0008060)2.34137813
104Hypoplasia of the fovea (HP:0007750)2.34137813
105Septo-optic dysplasia (HP:0100842)2.33807353
106Aplasia/Hypoplasia of the uvula (HP:0010293)2.33152174
107Megaloblastic anemia (HP:0001889)2.30549335
108Abnormal enzyme/coenzyme activity (HP:0012379)2.29241768
109Mesangial abnormality (HP:0001966)2.29139262
110Hypoglycemic seizures (HP:0002173)2.27760465
111Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.26787990
112Abolished electroretinogram (ERG) (HP:0000550)2.25605802
113Irritability (HP:0000737)2.24783937
114Abnormality of the vitamin B12 metabolism (HP:0004341)2.23405590
115Prolonged partial thromboplastin time (HP:0003645)2.23265598
116Medial flaring of the eyebrow (HP:0010747)2.22129860
117Abnormality of vitamin B metabolism (HP:0004340)2.21524462
118Congenital hepatic fibrosis (HP:0002612)2.20220253
119Abnormality of alkaline phosphatase activity (HP:0004379)2.17791939
120Symptomatic seizures (HP:0011145)2.17718648
121Abnormality of the fovea (HP:0000493)2.17516842
122Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.15966038
123Abnormality of vitamin metabolism (HP:0100508)2.15413813
124Birth length less than 3rd percentile (HP:0003561)2.12337596
125Tubulointerstitial fibrosis (HP:0005576)2.12017229
126Male pseudohermaphroditism (HP:0000037)2.11027590
127Gonadotropin excess (HP:0000837)2.10996388
128Cerebral edema (HP:0002181)2.10613824
129Pancreatitis (HP:0001733)2.10161196
130Focal motor seizures (HP:0011153)2.09938760
131Hemiparesis (HP:0001269)2.09702117
132Hyperbilirubinemia (HP:0002904)2.09396752
133Abnormality of serum amino acid levels (HP:0003112)2.08093880
134Dehydration (HP:0001944)2.06581398
135Anencephaly (HP:0002323)2.06284904
136Hyperinsulinemic hypoglycemia (HP:0000825)2.06198167
137Glomerulosclerosis (HP:0000096)2.05529174
138Meningioma (HP:0002858)2.04444268
139Abnormality of the intrinsic pathway (HP:0010989)2.04171821
140Steatorrhea (HP:0002570)2.03828064
141Sensorimotor neuropathy (HP:0007141)2.03387444
142Enlarged penis (HP:0000040)2.02803733
143Urinary glycosaminoglycan excretion (HP:0003541)2.02167004
144Mucopolysacchariduria (HP:0008155)2.02167004
145Congenital sensorineural hearing impairment (HP:0008527)2.02165776
146Hepatocellular carcinoma (HP:0001402)2.01930342
147Pendular nystagmus (HP:0012043)2.01815798
148Hypothermia (HP:0002045)2.01032172
149Dynein arm defect of respiratory motile cilia (HP:0012255)2.00645485
150Absent/shortened dynein arms (HP:0200106)2.00645485
151Methylmalonic aciduria (HP:0012120)1.98549503
152Nephrocalcinosis (HP:0000121)1.98093913
153Dysostosis multiplex (HP:0000943)1.97047966
154Nausea (HP:0002018)1.96298727
155Acute encephalopathy (HP:0006846)1.95279624
156Blue irides (HP:0000635)1.93459528
157Cerebellar dysplasia (HP:0007033)1.93381176
158Bony spicule pigmentary retinopathy (HP:0007737)1.92594917
159Stomach cancer (HP:0012126)1.92532555
160Spastic paraparesis (HP:0002313)1.92509152
161Bilateral microphthalmos (HP:0007633)1.92080975
162Bone cyst (HP:0012062)1.91817092
163Abnormal biliary tract physiology (HP:0012439)1.91745810
164Bile duct proliferation (HP:0001408)1.91745810
165Abnormality of the common coagulation pathway (HP:0010990)1.90961967
166Hypoplastic ischia (HP:0003175)1.89604949
167Esophageal atresia (HP:0002032)1.89127129
168Progressive inability to walk (HP:0002505)1.87308975
169Tubulointerstitial abnormality (HP:0001969)1.87297926
170Genetic anticipation (HP:0003743)1.84112532
171Fair hair (HP:0002286)1.83965368
172Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.81533112
173Horizontal nystagmus (HP:0000666)1.78772362
174Abnormal number of erythroid precursors (HP:0012131)1.76798410
175Occipital encephalocele (HP:0002085)1.76487558
176Prominent supraorbital ridges (HP:0000336)1.76117240
177Generalized hypopigmentation of hair (HP:0011358)1.75180940
178Lissencephaly (HP:0001339)1.74875327
179Gastrointestinal atresia (HP:0002589)1.74739592
180Conjunctival hamartoma (HP:0100780)1.73979821
181Anophthalmia (HP:0000528)1.73533056
182Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72875740
183Amelogenesis imperfecta (HP:0000705)1.71730297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK46.69338991
2BCKDK5.55441455
3WNK35.26718790
4PNCK5.17241953
5OXSR14.27410721
6ERBB43.45894534
7INSRR3.14982947
8TSSK63.11102461
9CASK3.05068898
10MST1R2.97877353
11ACVR1B2.83153347
12BMPR1B2.81277716
13ADRBK22.75342502
14WEE12.75177503
15FRK2.68632896
16STK392.60499865
17ZAK2.40871522
18ERN12.18321186
19STK38L1.91518963
20MST41.89286599
21TAOK31.79293723
22MAP2K21.78934425
23TLK11.77193083
24TRIB31.63847710
25MAPKAPK31.62624746
26FGFR41.57426609
27PDK41.52333606
28PDK31.52333606
29VRK11.50639210
30MAPK131.48883571
31PKN21.43336806
32TAF11.42435505
33TGFBR11.41667496
34PIK3CG1.34107492
35PTK61.25700368
36WNK11.23469036
37MAP3K41.20268417
38SGK2231.18460875
39SGK4941.18460875
40PDK21.16790716
41MAP3K21.16189803
42NTRK31.15784641
43PAK21.14529018
44MET1.14007141
45MAPK151.12711003
46MKNK21.10217091
47IRAK31.08513983
48NUAK11.05335700
49PRKCG1.04760900
50MUSK1.02411970
51GRK70.99931740
52DYRK1B0.95217657
53EPHB10.95103202
54MAPKAPK50.92828884
55LRRK20.91989643
56PTK20.90140007
57FLT30.89989192
58DYRK30.89381864
59MAP3K70.88345473
60PIK3CA0.88184849
61SIK10.86736187
62PRKD30.84265296
63NEK10.84226854
64MAP4K20.83418047
65BRSK20.83152040
66CAMK1D0.82780134
67CCNB10.80170723
68PRKAA20.79566280
69PRKCI0.77740931
70MAP2K10.74046298
71NEK20.73166202
72PAK30.69534296
73GSK3A0.69056600
74PRKCE0.67653732
75FER0.66692774
76TRPM70.65232530
77KIT0.64354516
78PDPK10.64336374
79CAMK1G0.63368544
80STK380.63171247
81ZAP700.63159358
82MAP3K140.63018533
83RIPK10.62828194
84PLK30.62771437
85TNIK0.62674627
86MYLK0.62245764
87NME10.61950081
88GRK50.61799123
89ABL20.60823214
90MAP3K30.60732040
91CSNK1G20.60276673
92PRKAA10.59702042
93DYRK20.59285890
94CDK30.58320981
95MAP3K90.56768497
96CSNK1G10.55215838
97SGK30.55179153
98PINK10.54745638
99EPHB20.54643055
100STK30.53976019
101DAPK20.53455121
102NTRK20.52220689
103CSNK1A1L0.50492281
104CHUK0.50411734
105NLK0.50394714
106PTK2B0.50066138
107EIF2AK30.48795135
108JAK20.48783577
109GRK60.48536491
110MAPK110.48508007
111PKN10.47222044
112KSR20.47085707
113SGK20.46362362
114PRKG20.46042585
115VRK20.45929398
116TXK0.44894709
117PLK20.44585073
118CAMKK20.43237344
119PRKCZ0.42502843
120CSNK1G30.42480075
121PDK10.42001969
122PRKD20.40329711
123NME20.40277931
124MKNK10.39558151
125MARK10.39193494
126PASK0.38981689
127LATS10.38800604
128PRKACG0.38603501
129TYRO30.38273056
130CAMK2A0.37946498
131TIE10.37423710
132CDK80.37187812
133OBSCN0.36304446
134MAP2K70.36042169
135MELK0.35053753
136PRKG10.34654259
137MAP3K130.34183786
138BRAF0.33768095
139IRAK20.33692234
140RPS6KA50.33268915
141NTRK10.31905274
142IRAK10.31414504
143CAMKK10.30933340
144FGFR20.29224358
145ARAF0.28487639
146SGK10.27753557
147MAP2K40.27007991
148IGF1R0.26981056
149MAP2K60.26081984
150CDC42BPA0.25946466
151KDR0.24222036
152LMTK20.24062397
153PRKCA0.22906181
154CSK0.21180513
155NEK90.20899248
156CAMK2G0.20410305
157STK110.19236631
158PRKACA0.18737138
159GRK10.18155774
160MAP3K10.17085319
161TGFBR20.16133530
162ADRBK10.15541071
163ERBB20.15459967
164PRKCQ0.14056671
165EPHA30.13761448
166PDGFRB0.13579273

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.50128402
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.91183624
3Sulfur metabolism_Homo sapiens_hsa009202.73550129
4Butanoate metabolism_Homo sapiens_hsa006502.70668994
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.69308503
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66300578
7Propanoate metabolism_Homo sapiens_hsa006402.52628503
8Tryptophan metabolism_Homo sapiens_hsa003802.35770292
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.32027088
10Fatty acid degradation_Homo sapiens_hsa000712.31482934
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.26852406
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.26235287
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.24281840
14Primary bile acid biosynthesis_Homo sapiens_hsa001202.23892574
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23860506
16Cyanoamino acid metabolism_Homo sapiens_hsa004602.21941122
17Phototransduction_Homo sapiens_hsa047442.18562484
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.07862978
19Vitamin digestion and absorption_Homo sapiens_hsa049772.07852232
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.03600019
21Peroxisome_Homo sapiens_hsa041462.03034678
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.97392018
23Chemical carcinogenesis_Homo sapiens_hsa052041.86051703
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85057406
25Pyruvate metabolism_Homo sapiens_hsa006201.84238516
26Arginine biosynthesis_Homo sapiens_hsa002201.79979438
27Nitrogen metabolism_Homo sapiens_hsa009101.79267058
28Fat digestion and absorption_Homo sapiens_hsa049751.78099132
29Nicotine addiction_Homo sapiens_hsa050331.74397388
30Taste transduction_Homo sapiens_hsa047421.69016860
31beta-Alanine metabolism_Homo sapiens_hsa004101.68958290
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.67146158
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.67098389
34Collecting duct acid secretion_Homo sapiens_hsa049661.66798849
35Glutathione metabolism_Homo sapiens_hsa004801.59677468
36Histidine metabolism_Homo sapiens_hsa003401.57802732
37Fatty acid metabolism_Homo sapiens_hsa012121.55758323
38Starch and sucrose metabolism_Homo sapiens_hsa005001.54732158
39Bile secretion_Homo sapiens_hsa049761.53958242
40Folate biosynthesis_Homo sapiens_hsa007901.53655647
41Selenocompound metabolism_Homo sapiens_hsa004501.48973950
42Ovarian steroidogenesis_Homo sapiens_hsa049131.47886561
43Carbon metabolism_Homo sapiens_hsa012001.29912740
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25070027
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23447106
46Phenylalanine metabolism_Homo sapiens_hsa003601.21365257
47PPAR signaling pathway_Homo sapiens_hsa033201.20748329
48Glycerolipid metabolism_Homo sapiens_hsa005611.18006328
49Fanconi anemia pathway_Homo sapiens_hsa034601.17779288
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17403646
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13922063
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.13537395
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13474734
54Arginine and proline metabolism_Homo sapiens_hsa003301.13359487
55Fatty acid biosynthesis_Homo sapiens_hsa000611.12126200
56Retinol metabolism_Homo sapiens_hsa008301.11867126
57Pancreatic secretion_Homo sapiens_hsa049721.10421182
58Drug metabolism - other enzymes_Homo sapiens_hsa009831.10218802
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08530692
60Protein digestion and absorption_Homo sapiens_hsa049741.06507451
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05405171
62Huntingtons disease_Homo sapiens_hsa050160.98699728
63Cardiac muscle contraction_Homo sapiens_hsa042600.95480360
64Circadian rhythm_Homo sapiens_hsa047100.95298051
65Lysine degradation_Homo sapiens_hsa003100.92876568
66Morphine addiction_Homo sapiens_hsa050320.92000018
67Alzheimers disease_Homo sapiens_hsa050100.91386692
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91004995
69Biosynthesis of amino acids_Homo sapiens_hsa012300.90154792
70Steroid biosynthesis_Homo sapiens_hsa001000.89747100
71GABAergic synapse_Homo sapiens_hsa047270.88498565
72Homologous recombination_Homo sapiens_hsa034400.87617691
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87134555
74Calcium signaling pathway_Homo sapiens_hsa040200.86239916
75Complement and coagulation cascades_Homo sapiens_hsa046100.84075953
76Other glycan degradation_Homo sapiens_hsa005110.83191814
77Fatty acid elongation_Homo sapiens_hsa000620.82979026
78Tyrosine metabolism_Homo sapiens_hsa003500.80366976
79Olfactory transduction_Homo sapiens_hsa047400.79771882
80ABC transporters_Homo sapiens_hsa020100.79358095
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.76599033
82Mineral absorption_Homo sapiens_hsa049780.76212509
83Gastric acid secretion_Homo sapiens_hsa049710.74566628
84Serotonergic synapse_Homo sapiens_hsa047260.73869693
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73627322
86Basal cell carcinoma_Homo sapiens_hsa052170.73071213
87Basal transcription factors_Homo sapiens_hsa030220.72987299
88Insulin secretion_Homo sapiens_hsa049110.70166607
89Fructose and mannose metabolism_Homo sapiens_hsa000510.68381808
90Sulfur relay system_Homo sapiens_hsa041220.65806401
91Circadian entrainment_Homo sapiens_hsa047130.64670206
92Linoleic acid metabolism_Homo sapiens_hsa005910.62994855
93Salivary secretion_Homo sapiens_hsa049700.62634044
94Glutamatergic synapse_Homo sapiens_hsa047240.61567613
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60870541
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60342479
97Cocaine addiction_Homo sapiens_hsa050300.59654267
98Oxidative phosphorylation_Homo sapiens_hsa001900.59594684
99Ribosome_Homo sapiens_hsa030100.56985640
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56342746
101Protein export_Homo sapiens_hsa030600.55501636
102Metabolic pathways_Homo sapiens_hsa011000.54674322
103Pentose phosphate pathway_Homo sapiens_hsa000300.54343966
104Dorso-ventral axis formation_Homo sapiens_hsa043200.51801309
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.51727237
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50834289
107Thyroid hormone synthesis_Homo sapiens_hsa049180.49725443
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47940238
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41429970
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.41207027
111Lysosome_Homo sapiens_hsa041420.40665128
112Arachidonic acid metabolism_Homo sapiens_hsa005900.40353280
113Galactose metabolism_Homo sapiens_hsa000520.39312253
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.38984963
115Caffeine metabolism_Homo sapiens_hsa002320.37963147
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34654983
117TGF-beta signaling pathway_Homo sapiens_hsa043500.34129630
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33662085
119One carbon pool by folate_Homo sapiens_hsa006700.31490779
120Renin-angiotensin system_Homo sapiens_hsa046140.30284537
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27128051
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26675164
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25425053
124RNA degradation_Homo sapiens_hsa030180.24483215
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24331722
126Staphylococcus aureus infection_Homo sapiens_hsa051500.23155290
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22139551
128Insulin resistance_Homo sapiens_hsa049310.19175622
129Vibrio cholerae infection_Homo sapiens_hsa051100.17724977
130Parkinsons disease_Homo sapiens_hsa050120.13104665
131Sphingolipid metabolism_Homo sapiens_hsa006000.12545899
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.10034650
133Ether lipid metabolism_Homo sapiens_hsa005650.09479939
134Glucagon signaling pathway_Homo sapiens_hsa049220.09440253
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.08490355
136Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08011416
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.07915742

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