SULT1A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)7.50469911
2regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.72934482
3very-low-density lipoprotein particle assembly (GO:0034379)6.53171399
4epoxygenase P450 pathway (GO:0019373)6.26989939
5plasma lipoprotein particle assembly (GO:0034377)6.25454015
6NADH metabolic process (GO:0006734)6.04227273
7regulation of triglyceride catabolic process (GO:0010896)5.99811524
8intestinal absorption (GO:0050892)5.72657735
9regulation of guanylate cyclase activity (GO:0031282)5.70758301
10phospholipid efflux (GO:0033700)5.68917028
11fat-soluble vitamin biosynthetic process (GO:0042362)5.61521696
12protein-lipid complex assembly (GO:0065005)5.56873816
13regulation of cholesterol esterification (GO:0010872)5.53564778
14high-density lipoprotein particle remodeling (GO:0034375)5.41096308
15lipoprotein transport (GO:0042953)5.31693744
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.29044096
17plasma lipoprotein particle remodeling (GO:0034369)5.08163997
18protein-lipid complex remodeling (GO:0034368)5.08163997
19macromolecular complex remodeling (GO:0034367)5.08163997
20diacylglycerol metabolic process (GO:0046339)5.03777970
21fructose metabolic process (GO:0006000)4.99026930
22positive regulation of triglyceride lipase activity (GO:0061365)4.97071756
23positive regulation of lipoprotein lipase activity (GO:0051006)4.97071756
24drug metabolic process (GO:0017144)4.79844251
25reverse cholesterol transport (GO:0043691)4.75899939
26regulation of bile acid biosynthetic process (GO:0070857)4.68950086
27plasma lipoprotein particle organization (GO:0071827)4.65499835
28cholesterol efflux (GO:0033344)4.52676652
29protein-lipid complex subunit organization (GO:0071825)4.37786647
30lipoprotein metabolic process (GO:0042157)4.31767258
31bile acid and bile salt transport (GO:0015721)4.28700053
32positive regulation of guanylate cyclase activity (GO:0031284)4.22995844
33drug catabolic process (GO:0042737)4.20992521
34regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.17683549
35endocrine process (GO:0050886)4.17683549
36regulation of systemic arterial blood pressure by hormone (GO:0001990)4.17683549
37urea metabolic process (GO:0019627)3.98446775
38urea cycle (GO:0000050)3.96338215
39exogenous drug catabolic process (GO:0042738)3.96247622
40low-density lipoprotein particle remodeling (GO:0034374)3.92113963
41uronic acid metabolic process (GO:0006063)3.87878819
42glucuronate metabolic process (GO:0019585)3.87878819
43regulation of cellular extravasation (GO:0002691)3.86141776
44flavonoid metabolic process (GO:0009812)3.81282378
45hormone catabolic process (GO:0042447)3.80690431
46cellular glucuronidation (GO:0052695)3.78858855
47positive regulation of fatty acid biosynthetic process (GO:0045723)3.76467172
48negative regulation of cholesterol transport (GO:0032375)3.73678617
49negative regulation of sterol transport (GO:0032372)3.73678617
50alkaloid metabolic process (GO:0009820)3.67750551
51ethanol oxidation (GO:0006069)3.67588435
52nitrogen cycle metabolic process (GO:0071941)3.66345469
53L-ascorbic acid metabolic process (GO:0019852)3.63460055
54GDP-mannose metabolic process (GO:0019673)3.63125726
55cholesterol homeostasis (GO:0042632)3.59836781
56glutamine family amino acid biosynthetic process (GO:0009084)3.59407963
57regulation of cGMP biosynthetic process (GO:0030826)3.58542544
58regulation of systemic arterial blood pressure (GO:0003073)3.58015746
59transepithelial transport (GO:0070633)3.56945650
60positive regulation of lipid catabolic process (GO:0050996)3.53913774
61sterol homeostasis (GO:0055092)3.52353962
62fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.50737815
63bile acid metabolic process (GO:0008206)3.45429917
64vitamin biosynthetic process (GO:0009110)3.43658204
65arginine metabolic process (GO:0006525)3.39017500
66proline metabolic process (GO:0006560)3.38363342
67renal system process involved in regulation of blood volume (GO:0001977)3.37787166
68vitamin transmembrane transport (GO:0035461)3.35007967
69nucleoside diphosphate biosynthetic process (GO:0009133)3.28321386
70protein carboxylation (GO:0018214)3.21779199
71peptidyl-glutamic acid carboxylation (GO:0017187)3.21779199
72positive regulation of triglyceride metabolic process (GO:0090208)3.19578512
73renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.18685084
74receptor guanylyl cyclase signaling pathway (GO:0007168)3.18079680
75glycosphingolipid catabolic process (GO:0046479)3.17766486
76homocysteine metabolic process (GO:0050667)3.15040923
77glycolipid catabolic process (GO:0019377)3.13711028
78peptide catabolic process (GO:0043171)3.13054660
79plasma lipoprotein particle clearance (GO:0034381)3.12768771
80oxaloacetate metabolic process (GO:0006107)3.06936385
81drug transport (GO:0015893)3.06443554
82vitamin transport (GO:0051180)3.04690719
83omega-hydroxylase P450 pathway (GO:0097267)3.00734620
84maintenance of gastrointestinal epithelium (GO:0030277)3.00529104
85regulation of cholesterol homeostasis (GO:2000188)3.00007713
86proline biosynthetic process (GO:0006561)2.98744674
87fat-soluble vitamin metabolic process (GO:0006775)2.98356748
88digestion (GO:0007586)2.95909767
89triglyceride homeostasis (GO:0070328)2.95661567
90acylglycerol homeostasis (GO:0055090)2.95661567
91regulation of triglyceride metabolic process (GO:0090207)2.94163279
92glycerol metabolic process (GO:0006071)2.93832065
93glutathione biosynthetic process (GO:0006750)2.92764903
94ethanol metabolic process (GO:0006067)2.91033884
95intestinal cholesterol absorption (GO:0030299)2.90713790
96alditol metabolic process (GO:0019400)2.90625957
97peptide hormone processing (GO:0016486)2.90087047
98transcytosis (GO:0045056)2.89881552
99regulation of cGMP metabolic process (GO:0030823)2.88159221
100nonribosomal peptide biosynthetic process (GO:0019184)2.88004340

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.14561447
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.86140183
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.77666216
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.57469540
5HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.41097436
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.37002491
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.35740868
8CDX2_20551321_ChIP-Seq_CACO-2_Human3.33804037
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.32914772
10EGR1_23403033_ChIP-Seq_LIVER_Mouse3.26926397
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.80671984
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.36785343
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.25611544
14GATA4_25053715_ChIP-Seq_YYC3_Human2.22077472
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.19712082
16LXR_22292898_ChIP-Seq_THP-1_Human2.11617116
17GATA6_25053715_ChIP-Seq_YYC3_Human1.97199532
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.96035223
19SOX2_27498859_Chip-Seq_STOMACH_Mouse1.91680212
20GATA1_22025678_ChIP-Seq_K562_Human1.85127757
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80579929
22BCL6_27268052_Chip-Seq_Bcells_Human1.79408004
23BCOR_27268052_Chip-Seq_Bcells_Human1.74712024
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.70849908
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68407173
26* HNF4A_19822575_ChIP-Seq_HepG2_Human1.65409333
27TET1_21451524_ChIP-Seq_MESCs_Mouse1.64082617
28NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.62751785
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61560880
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60320337
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59550770
32BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.59388484
33SOX2_20726797_ChIP-Seq_SW620_Human1.52204303
34PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.50125249
35* SA1_27219007_Chip-Seq_Bcells_Human1.47681057
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.44906311
37SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.44714973
38E2F1_20622854_ChIP-Seq_HELA_Human1.44009537
39SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41674138
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.40758481
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40455750
42RACK7_27058665_Chip-Seq_MCF-7_Human1.40139943
43SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39316371
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.38341164
45P68_20966046_ChIP-Seq_HELA_Human1.38286274
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35319724
47NANOG_20526341_ChIP-Seq_ESCs_Human1.33629953
48CTCF_27219007_Chip-Seq_Bcells_Human1.32080311
49CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30640213
50PHF8_20622854_ChIP-Seq_HELA_Human1.30554555
51GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29806413
52CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29458861
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28527198
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24012742
55VDR_21846776_ChIP-Seq_THP-1_Human1.23829700
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20676252
57CTCF_20526341_ChIP-Seq_ESCs_Human1.19478521
58JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.17753557
59P300_27268052_Chip-Seq_Bcells_Human1.17367825
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15799396
61SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15187616
62PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13361576
63RAD21_21589869_ChIP-Seq_MESCs_Mouse1.10967148
64RARA_24833708_ChIP-Seq_LIVER_Mouse1.09575296
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09117872
66ETS1_21867929_ChIP-Seq_TH2_Mouse1.08336171
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06483210
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.04715682
69VDR_24763502_ChIP-Seq_THP-1_Human1.03593602
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02872176
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02839237
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02456323
73P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02370835
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.01695955
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01506190
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01394434
77EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01248079
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01108952
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99939167
80RAC3_21632823_ChIP-Seq_H3396_Human0.99795651
81YY1_22570637_ChIP-Seq_MALME-3M_Human0.99307520
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99273938
83ESR1_21235772_ChIP-Seq_MCF-7_Human0.97960148
84ESR2_21235772_ChIP-Seq_MCF-7_Human0.97883574
85ERA_21632823_ChIP-Seq_H3396_Human0.97805516
86SOX2_21211035_ChIP-Seq_LN229_Human0.97552697
87RARB_24833708_ChIP-Seq_LIVER_Mouse0.97388181
88GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97019311
89* CEBPB_22108803_ChIP-Seq_LS180_Human0.96405299
90SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94128805
91TAF2_19829295_ChIP-Seq_ESCs_Human0.93915153
92FOXO3_23340844_ChIP-Seq_DLD1_Human0.93035629
93AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92199822
94SMC4_20622854_ChIP-Seq_HELA_Human0.91074866
95CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90567036
96CLOCK_20551151_ChIP-Seq_293T_Human0.90210432
97RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89909635
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89359705
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89194008
100ZNF263_19887448_ChIP-Seq_K562_Human0.88352548

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.02986126
2MP0002139_abnormal_hepatobiliary_system5.49059155
3MP0009840_abnormal_foam_cell4.49894042
4MP0005085_abnormal_gallbladder_physiolo4.49147690
5MP0001666_abnormal_nutrient_absorption4.41976188
6MP0005365_abnormal_bile_salt4.22598801
7MP0004019_abnormal_vitamin_homeostasis3.26909087
8MP0003183_abnormal_peptide_metabolism3.17068552
9MP0010329_abnormal_lipoprotein_level2.94865801
10MP0003806_abnormal_nucleotide_metabolis2.59362353
11MP0004264_abnormal_extraembryonic_tissu2.48704732
12MP0008875_abnormal_xenobiotic_pharmacok2.43185263
13MP0005332_abnormal_amino_acid2.34104810
14MP0004147_increased_porphyrin_level2.32574492
15MP0010155_abnormal_intestine_physiology2.15794997
16MP0003252_abnormal_bile_duct1.91934107
17MP0009643_abnormal_urine_homeostasis1.87133680
18MP0002876_abnormal_thyroid_physiology1.79649608
19MP0005670_abnormal_white_adipose1.77142595
20MP0002138_abnormal_hepatobiliary_system1.71374131
21MP0001764_abnormal_homeostasis1.68047842
22MP0005409_darkened_coat_color1.63280501
23MP0003866_abnormal_defecation1.62024998
24MP0005451_abnormal_body_composition1.56794403
25MP0002118_abnormal_lipid_homeostasis1.54097529
26MP0009379_abnormal_foot_pigmentation1.53768092
27MP0003868_abnormal_feces_composition1.50455621
28MP0005636_abnormal_mineral_homeostasis1.45402006
29MP0003195_calcinosis1.42581952
30MP0001664_abnormal_digestion1.42514349
31MP0000609_abnormal_liver_physiology1.41231628
32MP0003718_maternal_effect1.30644329
33MP0003191_abnormal_cellular_cholesterol1.30356359
34MP0005058_abnormal_lysosome_morphology1.30281863
35MP0001765_abnormal_ion_homeostasis1.25775274
36MP0002132_abnormal_respiratory_system1.25275404
37MP0004043_abnormal_pH_regulation1.22798184
38MP0000678_abnormal_parathyroid_gland1.22596803
39MP0001756_abnormal_urination1.17718825
40MP0005166_decreased_susceptibility_to1.17681460
41MP0000490_abnormal_crypts_of1.14408843
42MP0005584_abnormal_enzyme/coenzyme_acti1.13512233
43MP0000538_abnormal_urinary_bladder1.12138687
44MP0002136_abnormal_kidney_physiology1.10136755
45MP0005319_abnormal_enzyme/_coenzyme1.09573998
46MP0003879_abnormal_hair_cell1.09191604
47MP0003724_increased_susceptibility_to1.09112444
48MP0008469_abnormal_protein_level1.02483278
49MP0000477_abnormal_intestine_morphology1.01271386
50MP0009785_altered_susceptibility_to1.00931192
51MP0004782_abnormal_surfactant_physiolog0.95318669
52MP0003878_abnormal_ear_physiology0.94761225
53MP0005377_hearing/vestibular/ear_phenot0.94761225
54MP0009764_decreased_sensitivity_to0.93355646
55MP0001663_abnormal_digestive_system0.93075712
56MP0005448_abnormal_energy_balance0.93050809
57MP0009642_abnormal_blood_homeostasis0.90469642
58MP0001845_abnormal_inflammatory_respons0.89423263
59MP0003436_decreased_susceptibility_to0.88622703
60MP0009697_abnormal_copulation0.88587457
61MP0001188_hyperpigmentation0.87899721
62MP0005025_abnormal_response_to0.86584236
63MP0005535_abnormal_body_temperature0.85776172
64MP0010234_abnormal_vibrissa_follicle0.80724923
65MP0001873_stomach_inflammation0.79247034
66MP0002971_abnormal_brown_adipose0.77207090
67MP0005174_abnormal_tail_pigmentation0.76116760
68MP0009115_abnormal_fat_cell0.75295613
69MP0008872_abnormal_physiological_respon0.71171023
70MP0003315_abnormal_perineum_morphology0.70789042
71MP0002822_catalepsy0.70588978
72MP0001835_abnormal_antigen_presentation0.70343520
73MP0002148_abnormal_hypersensitivity_rea0.70096852
74MP0004858_abnormal_nervous_system0.69819133
75MP0003638_abnormal_response/metabolism_0.67449315
76MP0001986_abnormal_taste_sensitivity0.64066246
77MP0005381_digestive/alimentary_phenotyp0.63573062
78MP0000249_abnormal_blood_vessel0.62276105
79MP0000015_abnormal_ear_pigmentation0.59211898
80MP0006036_abnormal_mitochondrial_physio0.58928299
81MP0005334_abnormal_fat_pad0.58616782
82MP0002078_abnormal_glucose_homeostasis0.58124465
83MP0000598_abnormal_liver_morphology0.56476562
84MP0000230_abnormal_systemic_arterial0.56311725
85MP0001790_abnormal_immune_system0.55921628
86MP0005387_immune_system_phenotype0.55921628
87MP0000604_amyloidosis0.55447222
88MP0002166_altered_tumor_susceptibility0.54776903
89MP0000685_abnormal_immune_system0.54632382
90MP0001501_abnormal_sleep_pattern0.53511663
91MP0005376_homeostasis/metabolism_phenot0.52852924
92MP0003953_abnormal_hormone_level0.52844300
93MP0006082_CNS_inflammation0.52351348
94MP0005666_abnormal_adipose_tissue0.50655356
95MP0009333_abnormal_splenocyte_physiolog0.50066361
96MP0010352_gastrointestinal_tract_polyps0.49810682
97MP0005410_abnormal_fertilization0.48963732
98MP0002419_abnormal_innate_immunity0.48579695
99MP0001533_abnormal_skeleton_physiology0.48110312
100MP0001800_abnormal_humoral_immune0.47979575

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)7.60349557
2Hypobetalipoproteinemia (HP:0003563)6.84585355
3Malnutrition (HP:0004395)5.45270167
4Systemic lupus erythematosus (HP:0002725)5.25404302
5Abnormality of proline metabolism (HP:0010907)5.19543124
6Hydroxyprolinuria (HP:0003080)5.19543124
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.62490648
8Xanthomatosis (HP:0000991)4.06832828
9Widely patent fontanelles and sutures (HP:0004492)3.97339528
10Fat malabsorption (HP:0002630)3.90287955
11Complement deficiency (HP:0004431)3.87916223
12Abnormality of the vitamin B12 metabolism (HP:0004341)3.86019289
13Nausea (HP:0002018)3.80053702
14Hyperglycinuria (HP:0003108)3.75736391
15Ileus (HP:0002595)3.75030395
16Hypolipoproteinemia (HP:0010981)3.71326157
17Abnormality of vitamin B metabolism (HP:0004340)3.62714619
18Deep venous thrombosis (HP:0002625)3.60672646
19Acanthocytosis (HP:0001927)3.57957283
20Prolonged partial thromboplastin time (HP:0003645)3.56734355
21Hemorrhage of the eye (HP:0011885)3.55285612
22Abnormality of serine family amino acid metabolism (HP:0010894)3.50625388
23Abnormality of glycine metabolism (HP:0010895)3.50625388
24Abnormality of urine glucose concentration (HP:0011016)3.41254957
25Glycosuria (HP:0003076)3.41254957
26Pigmentary retinal degeneration (HP:0001146)3.35680192
27Abnormality of complement system (HP:0005339)3.35032112
28Glomerulonephritis (HP:0000099)3.28718780
29Confusion (HP:0001289)3.23808791
30Abnormality of vitamin metabolism (HP:0100508)3.20496846
31Chronic diarrhea (HP:0002028)3.18996744
32Proximal tubulopathy (HP:0000114)3.15007114
33Hyperammonemia (HP:0001987)3.09301072
34Joint hemorrhage (HP:0005261)3.04045422
35Hyperlipoproteinemia (HP:0010980)3.01090953
36Potter facies (HP:0002009)2.95884794
37Facial shape deformation (HP:0011334)2.95884794
38Abnormality of pyrimidine metabolism (HP:0004353)2.94805541
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.94031700
40Wide cranial sutures (HP:0010537)2.90967732
41Decreased circulating renin level (HP:0003351)2.85647921
42Alkalosis (HP:0001948)2.63047915
43Megaloblastic anemia (HP:0001889)2.61725257
44Dicarboxylic aciduria (HP:0003215)2.59817905
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59817905
46Abnormality of aromatic amino acid family metabolism (HP:0004338)2.59133377
47Steatorrhea (HP:0002570)2.57994665
48Hypophosphatemia (HP:0002148)2.56391286
49Epidermoid cyst (HP:0200040)2.56109675
50Abnormality of nucleobase metabolism (HP:0010932)2.54601140
51Congenital sensorineural hearing impairment (HP:0008527)2.53758936
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.53758475
53Metabolic acidosis (HP:0001942)2.53111072
54Abnormal urine phosphate concentration (HP:0012599)2.50404803
55Nephrolithiasis (HP:0000787)2.50117611
56Thin bony cortex (HP:0002753)2.48569459
57Hyperphosphaturia (HP:0003109)2.48358119
58Cerebral palsy (HP:0100021)2.43495030
59Nephritis (HP:0000123)2.37034330
60Abnormality of purine metabolism (HP:0004352)2.36174122
61Increased purine levels (HP:0004368)2.35859158
62Hyperuricemia (HP:0002149)2.35859158
63Conjugated hyperbilirubinemia (HP:0002908)2.32144800
64Intrahepatic cholestasis (HP:0001406)2.23698588
65Abnormality of renin-angiotensin system (HP:0000847)2.23397652
66Delayed CNS myelination (HP:0002188)2.23105255
67Hyperglycinemia (HP:0002154)2.22062445
68Metabolic alkalosis (HP:0200114)2.20639278
69Abnormality of sulfur amino acid metabolism (HP:0004339)2.19208376
70Delayed epiphyseal ossification (HP:0002663)2.13472841
71Abdominal distention (HP:0003270)2.13194776
72Hyperactive renin-angiotensin system (HP:0000841)2.11607328
73Lethargy (HP:0001254)2.08207559
74Abnormality of the costochondral junction (HP:0000919)2.07614601
75Posterior subcapsular cataract (HP:0007787)2.07007413
76Gout (HP:0001997)2.06009375
77Generalized aminoaciduria (HP:0002909)2.05638562
78Vacuolated lymphocytes (HP:0001922)2.04868051
79Poikilocytosis (HP:0004447)2.01959284
80Abnormality of small intestinal villus morphology (HP:0011472)1.99180613
81Villous atrophy (HP:0011473)1.99180613
82Pustule (HP:0200039)1.97696448
83Pancreatitis (HP:0001733)1.96798427
84Irritability (HP:0000737)1.93843486
85Petechiae (HP:0000967)1.92386699
86Abnormal enzyme/coenzyme activity (HP:0012379)1.92312923
87Hypercholesterolemia (HP:0003124)1.92220414
88Abnormality of alkaline phosphatase activity (HP:0004379)1.88060992
89Eczematoid dermatitis (HP:0000976)1.86728403
90Vomiting (HP:0002013)1.85444213
91Hypotension (HP:0002615)1.84573682
92Spontaneous abortion (HP:0005268)1.83414215
93Hypophosphatemic rickets (HP:0004912)1.83269834
94Purpura (HP:0000979)1.82629325
95Subcapsular cataract (HP:0000523)1.82613083
96Abnormal tarsal ossification (HP:0008369)1.81692963
97Vascular calcification (HP:0004934)1.81127692
98Amyloidosis (HP:0011034)1.77434522
99Methylmalonic aciduria (HP:0012120)1.75102358
100Rickets (HP:0002748)1.74465694

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.37752914
2ERN14.91410328
3MST1R3.79715235
4TESK23.37664400
5PRKG23.02080508
6FGFR42.81463511
7RIPK12.72852991
8EPHA22.46876083
9GRK62.29885275
10MAP3K122.12207793
11MAP4K12.05214542
12MUSK1.91620144
13PDK21.88555504
14WNK41.82690096
15TYK21.81617380
16KDR1.51775374
17NME11.44919347
18STK391.37020547
19PTK61.36151607
20MET1.31472637
21MAP3K111.31398416
22BCKDK1.22697348
23MYLK1.22653114
24TNIK1.22380944
25LMTK21.19603760
26MAP2K21.19372363
27FGFR31.17231236
28INSRR1.16359353
29MAP3K11.15557680
30MATK1.14215097
31KIT1.10046215
32PIK3CG1.07781688
33PIK3CA1.07324213
34TBK11.07038836
35MAP2K61.04335764
36OXSR11.03787449
37PDPK11.01903463
38EPHB10.97530179
39RIPK40.97482005
40MAP3K100.94592458
41NME20.94171849
42MAPK110.90263269
43PRKAA20.89529348
44CSF1R0.89425063
45MAPKAPK30.88235875
46MAP3K20.85385212
47DDR20.84036940
48ZAP700.83754125
49PIM20.81550396
50SYK0.80668639
51ABL20.78033352
52DYRK1B0.77629522
53DAPK10.77162935
54PDK10.68510798
55TESK10.67861436
56PRKACG0.66757843
57MAP3K30.66178187
58IRAK30.65345725
59LYN0.63144062
60EPHA40.63131782
61TGFBR20.62762041
62BLK0.62270527
63IRAK20.62187904
64NLK0.61781673
65IRAK10.61567831
66TLK10.61277092
67EPHA30.56642240
68CDC42BPA0.55135391
69IRAK40.54665416
70PINK10.54467014
71EPHB20.53946756
72GRK10.52653609
73MST40.52568080
74PRKCA0.50980430
75PRKCZ0.50777425
76ITK0.50688682
77ERBB20.50120403
78PRKCQ0.48920805
79PRKCI0.48202956
80CSK0.43045614
81FLT30.39975268
82SRC0.39428728
83LCK0.38975586
84JAK30.38874935
85IKBKE0.38285955
86LATS10.36322138
87PRKCD0.35810048
88IKBKB0.35217284
89TAOK10.34449912
90BTK0.34446407
91IGF1R0.34156832
92NUAK10.33096591
93SIK10.32996611
94BMX0.32181537
95TXK0.32078951
96FER0.31968029
97MAPK150.31445861
98MAP4K20.30583048
99PAK40.29506665
100MARK30.26684721

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.37469526
2Fat digestion and absorption_Homo sapiens_hsa049754.04671830
3Vitamin digestion and absorption_Homo sapiens_hsa049774.04319240
4Renin-angiotensin system_Homo sapiens_hsa046142.81266944
5Caffeine metabolism_Homo sapiens_hsa002322.58359135
6Arginine biosynthesis_Homo sapiens_hsa002202.54974786
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.43361433
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.36597484
9Histidine metabolism_Homo sapiens_hsa003402.34286847
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30511722
11* Chemical carcinogenesis_Homo sapiens_hsa052042.27635145
12Fructose and mannose metabolism_Homo sapiens_hsa000512.27408576
13Mineral absorption_Homo sapiens_hsa049782.23479239
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.16713618
15Retinol metabolism_Homo sapiens_hsa008302.11348516
16Drug metabolism - other enzymes_Homo sapiens_hsa009831.99742912
17PPAR signaling pathway_Homo sapiens_hsa033201.96591649
18Starch and sucrose metabolism_Homo sapiens_hsa005001.95924858
19Fatty acid degradation_Homo sapiens_hsa000711.85312910
20Galactose metabolism_Homo sapiens_hsa000521.81602668
21Linoleic acid metabolism_Homo sapiens_hsa005911.79549820
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.72311275
23Sulfur metabolism_Homo sapiens_hsa009201.63861778
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59706266
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.58000403
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56586148
27Phenylalanine metabolism_Homo sapiens_hsa003601.55962584
28Complement and coagulation cascades_Homo sapiens_hsa046101.55754167
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52825073
30Bile secretion_Homo sapiens_hsa049761.52377531
31Arachidonic acid metabolism_Homo sapiens_hsa005901.48632234
32Staphylococcus aureus infection_Homo sapiens_hsa051501.47971067
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39845323
34Protein digestion and absorption_Homo sapiens_hsa049741.38897413
35Tryptophan metabolism_Homo sapiens_hsa003801.38686432
36Arginine and proline metabolism_Homo sapiens_hsa003301.38618869
37Glycerolipid metabolism_Homo sapiens_hsa005611.38272853
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.34392275
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.29953936
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.26434001
41Asthma_Homo sapiens_hsa053101.20137594
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18444094
43Other glycan degradation_Homo sapiens_hsa005111.17298939
44Tyrosine metabolism_Homo sapiens_hsa003501.14285373
45Glutathione metabolism_Homo sapiens_hsa004801.10072444
46Peroxisome_Homo sapiens_hsa041461.02869334
47Sulfur relay system_Homo sapiens_hsa041220.99699788
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99559448
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97868984
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.96044080
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91767510
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91061294
53Fatty acid metabolism_Homo sapiens_hsa012120.83120602
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80857595
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79289970
56Allograft rejection_Homo sapiens_hsa053300.78010745
57Sphingolipid metabolism_Homo sapiens_hsa006000.74236209
58Butanoate metabolism_Homo sapiens_hsa006500.73870549
59Ether lipid metabolism_Homo sapiens_hsa005650.73498008
60Autoimmune thyroid disease_Homo sapiens_hsa053200.73112331
61Pentose phosphate pathway_Homo sapiens_hsa000300.72922743
62Biosynthesis of amino acids_Homo sapiens_hsa012300.72581064
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72399667
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.67166398
65Graft-versus-host disease_Homo sapiens_hsa053320.65581551
66Carbon metabolism_Homo sapiens_hsa012000.64545297
67Pyruvate metabolism_Homo sapiens_hsa006200.62815533
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57664992
69Folate biosynthesis_Homo sapiens_hsa007900.56189808
70ABC transporters_Homo sapiens_hsa020100.54641470
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52461291
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52385451
73Fatty acid elongation_Homo sapiens_hsa000620.50568294
74Metabolic pathways_Homo sapiens_hsa011000.48806743
75Propanoate metabolism_Homo sapiens_hsa006400.46647619
76Type I diabetes mellitus_Homo sapiens_hsa049400.46168536
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45878844
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33057109
79Fatty acid biosynthesis_Homo sapiens_hsa000610.32970746
80Antigen processing and presentation_Homo sapiens_hsa046120.32542992
81Pertussis_Homo sapiens_hsa051330.31882275
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29353228
83beta-Alanine metabolism_Homo sapiens_hsa004100.26856340
84Insulin resistance_Homo sapiens_hsa049310.26342594
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24790407
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.24323322
87Leishmaniasis_Homo sapiens_hsa051400.23983887
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22149384
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.22046776
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19141157
91Nitrogen metabolism_Homo sapiens_hsa009100.18411467
92Hematopoietic cell lineage_Homo sapiens_hsa046400.17318976
93Pancreatic secretion_Homo sapiens_hsa049720.13939434
94Primary immunodeficiency_Homo sapiens_hsa053400.09912881
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.09121290
96Glucagon signaling pathway_Homo sapiens_hsa049220.05022530
97African trypanosomiasis_Homo sapiens_hsa051430.04411178
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.04066284
99Thyroid hormone synthesis_Homo sapiens_hsa049180.03784013
100N-Glycan biosynthesis_Homo sapiens_hsa005100.01330026

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