SULT1A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.08378013
2L-phenylalanine catabolic process (GO:0006559)7.08378013
3L-phenylalanine metabolic process (GO:0006558)6.77137230
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.77137230
5aromatic amino acid family catabolic process (GO:0009074)6.29622316
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.22854053
7sulfur amino acid catabolic process (GO:0000098)5.68839104
8indole-containing compound catabolic process (GO:0042436)5.59686675
9indolalkylamine catabolic process (GO:0046218)5.59686675
10tryptophan catabolic process (GO:0006569)5.59686675
11kynurenine metabolic process (GO:0070189)5.45408128
12bile acid biosynthetic process (GO:0006699)5.41409368
13high-density lipoprotein particle remodeling (GO:0034375)5.40991814
14alpha-linolenic acid metabolic process (GO:0036109)5.35862874
15urea metabolic process (GO:0019627)5.30948444
16urea cycle (GO:0000050)5.30948444
17negative regulation of fibrinolysis (GO:0051918)5.30093052
18tryptophan metabolic process (GO:0006568)5.28205793
19glyoxylate metabolic process (GO:0046487)5.23069576
20cellular ketone body metabolic process (GO:0046950)5.11256774
21cysteine metabolic process (GO:0006534)5.09930038
22complement activation, alternative pathway (GO:0006957)5.09474423
23regulation of fibrinolysis (GO:0051917)5.05698708
24peptidyl-glutamic acid carboxylation (GO:0017187)5.01184324
25protein carboxylation (GO:0018214)5.01184324
26regulation of protein activation cascade (GO:2000257)4.91742950
27nitrogen cycle metabolic process (GO:0071941)4.91320511
28regulation of cholesterol esterification (GO:0010872)4.83986088
29regulation of triglyceride catabolic process (GO:0010896)4.79677024
30serine family amino acid catabolic process (GO:0009071)4.77349318
31bile acid metabolic process (GO:0008206)4.76707336
32reverse cholesterol transport (GO:0043691)4.70436753
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.67334516
34protein-lipid complex remodeling (GO:0034368)4.63569459
35macromolecular complex remodeling (GO:0034367)4.63569459
36plasma lipoprotein particle remodeling (GO:0034369)4.63569459
37phospholipid efflux (GO:0033700)4.61229269
38homocysteine metabolic process (GO:0050667)4.60565677
39regulation of complement activation (GO:0030449)4.57194040
40aromatic amino acid family metabolic process (GO:0009072)4.53810970
41negative regulation of sterol transport (GO:0032372)4.52880353
42negative regulation of cholesterol transport (GO:0032375)4.52880353
43acylglycerol homeostasis (GO:0055090)4.50042372
44triglyceride homeostasis (GO:0070328)4.50042372
45tyrosine metabolic process (GO:0006570)4.49948538
46amino-acid betaine metabolic process (GO:0006577)4.44726723
47bile acid and bile salt transport (GO:0015721)4.43360333
48ketone body metabolic process (GO:1902224)4.42597299
49plasma lipoprotein particle clearance (GO:0034381)4.37711494
50alpha-amino acid catabolic process (GO:1901606)4.35565444
51cellular glucuronidation (GO:0052695)4.35168276
52lysine catabolic process (GO:0006554)4.19982819
53lysine metabolic process (GO:0006553)4.19982819
54cellular amino acid catabolic process (GO:0009063)4.08002250
55ethanol oxidation (GO:0006069)4.04865294
56coenzyme catabolic process (GO:0009109)4.03468141
57drug catabolic process (GO:0042737)4.02766496
58cellular response to ATP (GO:0071318)4.00558497
59indolalkylamine metabolic process (GO:0006586)3.94470703
60cholesterol efflux (GO:0033344)3.94441944
61benzene-containing compound metabolic process (GO:0042537)3.92900726
62plasma lipoprotein particle assembly (GO:0034377)3.92261024
63cellular biogenic amine catabolic process (GO:0042402)3.92166467
64amine catabolic process (GO:0009310)3.92166467
65positive regulation of fatty acid oxidation (GO:0046321)3.88559429
66blood coagulation, intrinsic pathway (GO:0007597)3.88105097
67arginine metabolic process (GO:0006525)3.85300503
68low-density lipoprotein particle remodeling (GO:0034374)3.83644027
69positive regulation of fatty acid beta-oxidation (GO:0032000)3.83488048
70uronic acid metabolic process (GO:0006063)3.82970719
71glucuronate metabolic process (GO:0019585)3.82970719
72glycine metabolic process (GO:0006544)3.82138455
73glutamate metabolic process (GO:0006536)3.81906337
74negative regulation of lipase activity (GO:0060192)3.81657195
75short-chain fatty acid metabolic process (GO:0046459)3.80826817
76imidazole-containing compound metabolic process (GO:0052803)3.80086698
77branching involved in labyrinthine layer morphogenesis (GO:0060670)3.79920799
78fibrinolysis (GO:0042730)3.75075724
79positive regulation of lipid catabolic process (GO:0050996)3.74083918
80* flavonoid metabolic process (GO:0009812)3.70629812
81serine family amino acid metabolic process (GO:0009069)3.69333047
82aldehyde catabolic process (GO:0046185)3.68600735
83carboxylic acid catabolic process (GO:0046395)3.67831009
84organic acid catabolic process (GO:0016054)3.67831009
85cellular modified amino acid catabolic process (GO:0042219)3.67752514
86drug metabolic process (GO:0017144)3.67715405
87phospholipid homeostasis (GO:0055091)3.66798059
88cholesterol homeostasis (GO:0042632)3.65683596
89protein activation cascade (GO:0072376)3.65550325
90regulation of cell proliferation involved in kidney development (GO:1901722)3.64403660
91positive regulation of triglyceride lipase activity (GO:0061365)3.63802942
92positive regulation of lipoprotein lipase activity (GO:0051006)3.63802942
93cofactor catabolic process (GO:0051187)3.62147688
94sterol homeostasis (GO:0055092)3.58402624
95heme transport (GO:0015886)3.57113427
96very-low-density lipoprotein particle assembly (GO:0034379)3.56724634
97cellular anion homeostasis (GO:0030002)3.55818540
98regulation of bile acid biosynthetic process (GO:0070857)3.55026114
99complement activation (GO:0006956)3.55011661
100response to nitrosative stress (GO:0051409)3.54605946
101fatty acid oxidation (GO:0019395)3.54242798
102plasma lipoprotein particle organization (GO:0071827)3.53203357
103acute-phase response (GO:0006953)3.53017172
104* sulfation (GO:0051923)3.52310234
105exogenous drug catabolic process (GO:0042738)3.51903250
106monocarboxylic acid catabolic process (GO:0072329)3.51533297
107complement activation, classical pathway (GO:0006958)3.50626992
108opsonization (GO:0008228)3.45317589
109epoxygenase P450 pathway (GO:0019373)3.31359939
110cellular response to exogenous dsRNA (GO:0071360)3.23398964
111interferon-gamma secretion (GO:0072643)3.05642598
112positive regulation of mast cell activation (GO:0033005)3.05216434
113regulation of germinal center formation (GO:0002634)3.01590709
114regulation of cholesterol storage (GO:0010885)2.99331709
115diacylglycerol metabolic process (GO:0046339)2.95429401
116behavioral response to nicotine (GO:0035095)2.94751916
117positive regulation of triglyceride metabolic process (GO:0090208)2.91889280
118alkaloid metabolic process (GO:0009820)2.89572997
119antigen processing and presentation of endogenous antigen (GO:0019883)2.88329719
120antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.88078361
121positive regulation of fatty acid metabolic process (GO:0045923)2.86625220
122water-soluble vitamin biosynthetic process (GO:0042364)2.82964780
123neutrophil activation involved in immune response (GO:0002283)2.82683539
124antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.81922986
125regulation of mast cell activation (GO:0033003)2.81101755
126NAD biosynthetic process (GO:0009435)2.80699834
127positive regulation of triglyceride biosynthetic process (GO:0010867)2.79216812
128regulation of glomerulus development (GO:0090192)2.78793362
129transepithelial transport (GO:0070633)2.75671689
130macrophage activation involved in immune response (GO:0002281)2.73969464
131lipoprotein transport (GO:0042953)2.71978912
132regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.71340390
133positive regulation of digestive system process (GO:0060456)2.71133853
134negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.70098820
135immunoglobulin mediated immune response (GO:0016064)2.69993180
136regulation of sequestering of triglyceride (GO:0010889)2.68999729
137positive regulation of mast cell degranulation (GO:0043306)2.67741413
138positive regulation of mast cell activation involved in immune response (GO:0033008)2.67741413
139cytidine deamination (GO:0009972)2.64931712
140cytidine metabolic process (GO:0046087)2.64931712
141cytidine catabolic process (GO:0006216)2.64931712
142positive regulation by symbiont of host defense response (GO:0052509)2.64877143
143modulation by symbiont of host defense response (GO:0052031)2.64877143
144modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.64877143
145modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.64877143
146positive regulation by organism of defense response of other organism involved in symbiotic interact2.64877143
147modulation by symbiont of host immune response (GO:0052553)2.64877143
148positive regulation of gamma-delta T cell activation (GO:0046645)2.63946680
149negative regulation of cell killing (GO:0031342)2.61990725
150negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.61990725
1513-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.61097649
152* purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.61097649
153DNA deamination (GO:0045006)2.60783478
154antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.60129168
155angiotensin maturation (GO:0002003)2.57803823
156vitamin biosynthetic process (GO:0009110)2.57669933
157positive regulation of systemic arterial blood pressure (GO:0003084)2.54655169
158negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.54173836
159negative regulation of platelet activation (GO:0010544)2.51820006
160regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.51445373
161cell proliferation in forebrain (GO:0021846)2.50660166
162positive regulation of cAMP-mediated signaling (GO:0043950)2.49787927
163negative regulation of systemic arterial blood pressure (GO:0003085)2.48054965
164regulation of interferon-beta biosynthetic process (GO:0045357)2.47297116
165pyridine nucleotide biosynthetic process (GO:0019363)2.46462766
166nicotinamide nucleotide biosynthetic process (GO:0019359)2.46462766
167ethanol metabolic process (GO:0006067)2.45311154
168negative regulation of Rho protein signal transduction (GO:0035024)2.45271943
169positive regulation of fatty acid transport (GO:2000193)2.44337984
170intestinal absorption (GO:0050892)2.43827313
171regulation of phospholipid biosynthetic process (GO:0071071)2.42342638
172regulation of mast cell degranulation (GO:0043304)2.41930496
173detection of bacterium (GO:0016045)2.41402816
174positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.40309073
175detection of other organism (GO:0098543)2.40204818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.86380426
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.71210153
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.49016680
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.10719102
5* PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.72154112
6STAT6_21828071_ChIP-Seq_BEAS2B_Human5.63595360
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.10435366
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.89789828
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.65532900
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.59971611
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.28975129
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.60248255
13* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21624031
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.13885133
15* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.0787821
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.99642587
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.86629564
18VDR_24763502_ChIP-Seq_THP-1_Human1.82180025
19VDR_21846776_ChIP-Seq_THP-1_Human1.81198755
20RUNX_20019798_ChIP-Seq_JUKART_Human1.78359437
21IRF8_27001747_Chip-Seq_BMDM_Mouse1.65730229
22* CLOCK_20551151_ChIP-Seq_293T_Human1.61606555
23* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.60742293
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60371793
25BCL6_27268052_Chip-Seq_Bcells_Human1.56318141
26VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.55231004
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53520662
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52927032
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.48742978
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47302861
31FOXA2_19822575_ChIP-Seq_HepG2_Human1.45214364
32DROSHA_22980978_ChIP-Seq_HELA_Human1.43519912
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42602178
34HTT_18923047_ChIP-ChIP_STHdh_Human1.41091459
35TDRD3_21172665_ChIP-Seq_MCF-7_Human1.40452872
36GATA1_22025678_ChIP-Seq_K562_Human1.33077433
37BCOR_27268052_Chip-Seq_Bcells_Human1.31192192
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31000853
39E2F1_20622854_ChIP-Seq_HELA_Human1.29942549
40HNF4A_19822575_ChIP-Seq_HepG2_Human1.27369452
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26664241
42P68_20966046_ChIP-Seq_HELA_Human1.26388445
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25896288
44GATA3_27048872_Chip-Seq_THYMUS_Human1.24995620
45SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24717034
46IRF8_22096565_ChIP-ChIP_GC-B_Human1.24715370
47CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23824427
48STAT1_20625510_ChIP-Seq_HELA_Human1.23439622
49ERA_21632823_ChIP-Seq_H3396_Human1.23024782
50EZH2_22144423_ChIP-Seq_EOC_Human1.22237202
51RAC3_21632823_ChIP-Seq_H3396_Human1.19192167
52P300_27268052_Chip-Seq_Bcells_Human1.17896779
53VDR_24787735_ChIP-Seq_THP-1_Human1.14900423
54RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14747026
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14365563
56UTX_26944678_Chip-Seq_JUKART_Human1.13445747
57NANOG_20526341_ChIP-Seq_ESCs_Human1.11016049
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09567679
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09327087
60CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08892122
61STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08719586
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.08551770
63* PHF8_20622854_ChIP-Seq_HELA_Human1.08489109
64CDX2_20551321_ChIP-Seq_CACO-2_Human1.08258589
65YY1_22570637_ChIP-Seq_MALME-3M_Human1.07596955
66ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05808886
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04403351
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04301461
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03998265
70CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03936424
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03306333
72CTCF_20526341_ChIP-Seq_ESCs_Human1.02640908
73SPI1_23127762_ChIP-Seq_K562_Human1.02443619
74CTCF_21964334_ChIP-Seq_BJAB-B_Human1.02090290
75SPI1_20517297_ChIP-Seq_HL60_Human1.01972127
76EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99535707
77FOXH1_21741376_ChIP-Seq_ESCs_Human0.97403462
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97068067
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96457899
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96439202
81GATA4_25053715_ChIP-Seq_YYC3_Human0.95805974
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95568792
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95534842
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95517568
85MAF_26560356_Chip-Seq_TH1_Human0.94526508
86TET1_21451524_ChIP-Seq_MESCs_Mouse0.94369120
87SPI1_23547873_ChIP-Seq_NB4_Human0.93968898
88MYB_26560356_Chip-Seq_TH2_Human0.93305311
89GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93278362
90NCOR_22424771_ChIP-Seq_293T_Human0.92872453
91* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91887250
92GATA3_26560356_Chip-Seq_TH2_Human0.91459271
93* MAF_26560356_Chip-Seq_TH2_Human0.90360391
94JARID2_20075857_ChIP-Seq_MESCs_Mouse0.90173963
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89904463
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89577395
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89417114
98ZNF263_19887448_ChIP-Seq_K562_Human0.89229933
99RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88603189
100ESR2_21235772_ChIP-Seq_MCF-7_Human0.83803109
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82920088
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82877356
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82544108
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81430629
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.80415850
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79885433
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79871304
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.79551734
109AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77452141
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73640436
111GATA2_21666600_ChIP-Seq_HMVEC_Human0.73374531
112KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73058716
113RAD21_21589869_ChIP-Seq_MESCs_Mouse0.71158311
114RARA_24833708_ChIP-Seq_LIVER_Mouse0.70433942
115EGR1_19032775_ChIP-ChIP_M12_Human0.70059107
116GATA1_19941826_ChIP-Seq_K562_Human0.69502010
117SCL_19346495_ChIP-Seq_HPC-7_Human0.68318899
118LXR_22292898_ChIP-Seq_THP-1_Human0.67925039
119STAT3_1855785_ChIP-Seq_MESCs_Mouse0.66910071
120ESR1_21235772_ChIP-Seq_MCF-7_Human0.66079430
121GATA1_19941827_ChIP-Seq_MEL_Mouse0.65782013
122AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65625143
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.65447071
124RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.62689953
125GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.62444684
126SALL4_18804426_ChIP-ChIP_XEN_Mouse0.62183640
127RARB_24833708_ChIP-Seq_LIVER_Mouse0.62092027
128NRF2_20460467_ChIP-Seq_MEFs_Mouse0.61491740
129NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.61491740
130SOX2_20726797_ChIP-Seq_SW620_Human0.60884774
131LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.59796061
132GATA2_19941826_ChIP-Seq_K562_Human0.58625189
133ESR1_20079471_ChIP-ChIP_T-47D_Human0.56077860
134CEBPB_22108803_ChIP-Seq_LS180_Human0.54810521
135PPAR_26484153_Chip-Seq_NCI-H1993_Human0.54745295
136SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.54464470
137ESET_19884257_ChIP-Seq_ESCs_Mouse0.54397099
138PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.54217472
139MYC_19915707_ChIP-ChIP_AK7_Human0.52572419
140BP1_19119308_ChIP-ChIP_Hs578T_Human0.52391299
141AR_20517297_ChIP-Seq_VCAP_Human0.50437134
142FOXA1_25552417_ChIP-Seq_VCAP_Human0.50255552
143GATA6_25053715_ChIP-Seq_YYC3_Human0.50074352
144TP63_17297297_ChIP-ChIP_HaCaT_Human0.49297662
145TAF2_19829295_ChIP-Seq_ESCs_Human0.49034477
146FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.47972872
147PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46706574
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46328719
149P53_21459846_ChIP-Seq_SAOS-2_Human0.46186231
150FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.45893137
151FOXO3_23340844_ChIP-Seq_DLD1_Human0.45198487
152TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.45101603
153SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.44291260
154ERG_20517297_ChIP-Seq_VCAP_Human0.44187566
155NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.44142785
156BCAT_22108803_ChIP-Seq_LS180_Human0.43855984
157CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.43617629
158STAT1_17558387_ChIP-Seq_HELA_Human0.43170232
159LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.43038486
160RACK7_27058665_Chip-Seq_MCF-7_Human0.42780981
161ERG_21242973_ChIP-ChIP_JURKAT_Human0.42777428
162EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.42216975
163SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.41921141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.78119577
2MP0005360_urolithiasis7.01029591
3MP0005085_abnormal_gallbladder_physiolo6.14933471
4MP0005365_abnormal_bile_salt5.88129663
5MP0008875_abnormal_xenobiotic_pharmacok5.13706209
6MP0003806_abnormal_nucleotide_metabolis3.91993777
7MP0010329_abnormal_lipoprotein_level3.61091738
8MP0003252_abnormal_bile_duct3.60678484
9MP0009840_abnormal_foam_cell3.23782979
10MP0005083_abnormal_biliary_tract2.97677290
11MP0003191_abnormal_cellular_cholesterol2.71508734
12MP0001666_abnormal_nutrient_absorption2.59604023
13MP0005332_abnormal_amino_acid2.58741384
14MP0003195_calcinosis2.43680445
15MP0004019_abnormal_vitamin_homeostasis2.16151471
16MP0003183_abnormal_peptide_metabolism2.12219442
17MP0002118_abnormal_lipid_homeostasis2.11914950
18MP0000609_abnormal_liver_physiology2.10230770
19MP0002132_abnormal_respiratory_system2.08393587
20MP0003868_abnormal_feces_composition2.04118945
21MP0002138_abnormal_hepatobiliary_system2.00468402
22MP0005671_abnormal_response_to1.97005552
23MP0001485_abnormal_pinna_reflex1.95943570
24MP0001835_abnormal_antigen_presentation1.93817606
25MP0005319_abnormal_enzyme/_coenzyme1.85045802
26MP0001800_abnormal_humoral_immune1.81298926
27MP0002148_abnormal_hypersensitivity_rea1.77538689
28MP0001790_abnormal_immune_system1.77144341
29MP0005387_immune_system_phenotype1.77144341
30MP0002419_abnormal_innate_immunity1.76220567
31MP0000678_abnormal_parathyroid_gland1.65748202
32MP0001764_abnormal_homeostasis1.65153528
33MP0005000_abnormal_immune_tolerance1.65054903
34MP0002160_abnormal_reproductive_system1.62315640
35MP0005584_abnormal_enzyme/coenzyme_acti1.61522641
36MP0001986_abnormal_taste_sensitivity1.59871351
37MP0009697_abnormal_copulation1.59243408
38MP0005670_abnormal_white_adipose1.56496490
39MP0002723_abnormal_immune_serum1.51183364
40MP0003879_abnormal_hair_cell1.49546068
41MP0003172_abnormal_lysosome_physiology1.48445111
42MP0005646_abnormal_pituitary_gland1.47422122
43MP0002452_abnormal_antigen_presenting1.44173918
44MP0009643_abnormal_urine_homeostasis1.39383995
45MP0003186_abnormal_redox_activity1.35935077
46MP0010368_abnormal_lymphatic_system1.35062119
47MP0005451_abnormal_body_composition1.33624096
48MP0001819_abnormal_immune_cell1.33347749
49MP0002420_abnormal_adaptive_immunity1.33000638
50MP0003303_peritoneal_inflammation1.31967248
51MP0002277_abnormal_respiratory_mucosa1.26703743
52MP0001765_abnormal_ion_homeostasis1.24261093
53MP0003011_delayed_dark_adaptation1.23240040
54MP0000598_abnormal_liver_morphology1.17683655
55MP0003866_abnormal_defecation1.17144226
56MP0003724_increased_susceptibility_to1.16651606
57MP0009764_decreased_sensitivity_to1.15721939
58MP0001533_abnormal_skeleton_physiology1.14594573
59MP0005389_reproductive_system_phenotype1.12910271
60MP0003656_abnormal_erythrocyte_physiolo1.12027531
61MP0004130_abnormal_muscle_cell1.11358920
62MP0003705_abnormal_hypodermis_morpholog1.10975417
63MP0005647_abnormal_sex_gland1.10787554
64MP0009763_increased_sensitivity_to1.07943437
65MP0002653_abnormal_ependyma_morphology1.06346557
66MP0005636_abnormal_mineral_homeostasis1.03473536
67MP0004134_abnormal_chest_morphology1.03337829
68MP0002254_reproductive_system_inflammat1.02394702
69MP0001873_stomach_inflammation0.98977194
70MP0008469_abnormal_protein_level0.97789692
71MP0005167_abnormal_blood-brain_barrier0.97472655
72MP0001663_abnormal_digestive_system0.94651208
73MP0005084_abnormal_gallbladder_morpholo0.93825165
74MP0000716_abnormal_immune_system0.92969422
75MP0005174_abnormal_tail_pigmentation0.92020209
76MP0002405_respiratory_system_inflammati0.91481821
77MP0009333_abnormal_splenocyte_physiolog0.90748066
78MP0006036_abnormal_mitochondrial_physio0.90455263
79MP0003646_muscle_fatigue0.90439078
80MP0009642_abnormal_blood_homeostasis0.89555976
81MP0000604_amyloidosis0.88902453
82MP0000689_abnormal_spleen_morphology0.87253008
83MP0005310_abnormal_salivary_gland0.86802240
84MP0002971_abnormal_brown_adipose0.85408336
85MP0009765_abnormal_xenobiotic_induced0.84264421
86MP0005334_abnormal_fat_pad0.84008795
87MP0005464_abnormal_platelet_physiology0.83272718
88MP0002876_abnormal_thyroid_physiology0.83092206
89MP0003690_abnormal_glial_cell0.82838947
90MP0005376_homeostasis/metabolism_phenot0.81660612
91MP0001661_extended_life_span0.80626262
92MP0002822_catalepsy0.78739682
93MP0005666_abnormal_adipose_tissue0.75344962
94MP0002078_abnormal_glucose_homeostasis0.74851441
95MP0002398_abnormal_bone_marrow0.73246566
96MP0005535_abnormal_body_temperature0.70247136
97MP0001968_abnormal_touch/_nociception0.70030099
98MP0003878_abnormal_ear_physiology0.69849241
99MP0005377_hearing/vestibular/ear_phenot0.69849241
100MP0001664_abnormal_digestion0.69775637
101MP0005551_abnormal_eye_electrophysiolog0.68960454
102MP0001756_abnormal_urination0.67673596
103MP0005410_abnormal_fertilization0.67248443
104MP0005220_abnormal_exocrine_pancreas0.66719009
105MP0001440_abnormal_grooming_behavior0.66079470
106MP0002722_abnormal_immune_system0.65376129
107MP0004947_skin_inflammation0.65286986
108MP0005266_abnormal_metabolism0.64795493
109MP0003075_altered_response_to0.62688034
110MP0005448_abnormal_energy_balance0.59882059
111MP0005408_hypopigmentation0.59672338
112MP0003638_abnormal_response/metabolism_0.58627019
113MP0003436_decreased_susceptibility_to0.57937729
114MP0002136_abnormal_kidney_physiology0.56385195
115MP0008873_increased_physiological_sensi0.55073574
116MP0004782_abnormal_surfactant_physiolog0.54673888
117MP0000639_abnormal_adrenal_gland0.52222825
118MP0000249_abnormal_blood_vessel0.52019846
119MP0009115_abnormal_fat_cell0.49816407
120MP0009785_altered_susceptibility_to0.49127059
121MP0008874_decreased_physiological_sensi0.48932779
122MP0003300_gastrointestinal_ulcer0.48768048
123MP0000230_abnormal_systemic_arterial0.47255666
124MP0005166_decreased_susceptibility_to0.46977344
125MP0002837_dystrophic_cardiac_calcinosis0.45716567
126MP0003953_abnormal_hormone_level0.43964206
127MP0005058_abnormal_lysosome_morphology0.43829489
128MP0001845_abnormal_inflammatory_respons0.43506091
129MP0002796_impaired_skin_barrier0.42032611
130MP0004883_abnormal_blood_vessel0.41121073
131MP0004185_abnormal_adipocyte_glucose0.39731409
132MP0001853_heart_inflammation0.39234986
133MP0002928_abnormal_bile_duct0.39166911
134MP0006035_abnormal_mitochondrial_morpho0.39015294
135MP0005164_abnormal_response_to0.38607279
136MP0005025_abnormal_response_to0.37886203
137MP0008872_abnormal_physiological_respon0.37792983
138MP0010155_abnormal_intestine_physiology0.37246136
139MP0004147_increased_porphyrin_level0.37210815
140MP0002970_abnormal_white_adipose0.37062353
141MP0002060_abnormal_skin_morphology0.36639994
142MP0004264_abnormal_extraembryonic_tissu0.34929288
143MP0000685_abnormal_immune_system0.34657972
144MP0003329_amyloid_beta_deposits0.34476549
145MP0005395_other_phenotype0.34426907
146MP0009379_abnormal_foot_pigmentation0.33749131
147MP0009053_abnormal_anal_canal0.32786092
148MP0006082_CNS_inflammation0.32573604

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.97748731
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.93636374
3Intrahepatic cholestasis (HP:0001406)6.70901361
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.33562052
5Hypobetalipoproteinemia (HP:0003563)6.08381115
6Prolonged partial thromboplastin time (HP:0003645)6.02162333
7Xanthomatosis (HP:0000991)6.01369444
8Hyperlipoproteinemia (HP:0010980)5.58588770
9Complement deficiency (HP:0004431)5.11316294
10Joint hemorrhage (HP:0005261)4.79542377
11Hypolipoproteinemia (HP:0010981)4.76270810
12Hyperammonemia (HP:0001987)4.60540184
13Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.45504171
14Hypoalphalipoproteinemia (HP:0003233)4.33249473
15Abnormality of methionine metabolism (HP:0010901)4.25344338
16Abnormality of the common coagulation pathway (HP:0010990)4.24276391
17Epidermoid cyst (HP:0200040)4.20127219
18Abnormality of aspartate family amino acid metabolism (HP:0010899)4.08971424
19Abnormality of glutamine family amino acid metabolism (HP:0010902)4.07764743
20Ketosis (HP:0001946)4.06564698
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.04699586
22Hyperglycinemia (HP:0002154)4.04580341
23Hypoglycemic coma (HP:0001325)3.97785214
24Hyperglycinuria (HP:0003108)3.77438505
25Fat malabsorption (HP:0002630)3.72877626
26Abnormality of the intrinsic pathway (HP:0010989)3.72877525
27Abnormality of complement system (HP:0005339)3.72280952
28Abnormality of serine family amino acid metabolism (HP:0010894)3.70007796
29Abnormality of glycine metabolism (HP:0010895)3.70007796
30Hypercholesterolemia (HP:0003124)3.64523880
31Pendular nystagmus (HP:0012043)3.47095823
32Abnormality of fatty-acid metabolism (HP:0004359)3.45781149
33Abnormality of pyrimidine metabolism (HP:0004353)3.43523165
34Conjugated hyperbilirubinemia (HP:0002908)3.30366028
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.27549106
36Spontaneous abortion (HP:0005268)3.22489292
37Congenital sensorineural hearing impairment (HP:0008527)3.19200436
38Hyperbilirubinemia (HP:0002904)3.15190247
39Genetic anticipation (HP:0003743)3.14898377
40Abnormality of dicarboxylic acid metabolism (HP:0010995)3.04748071
41Dicarboxylic aciduria (HP:0003215)3.04748071
42Abolished electroretinogram (ERG) (HP:0000550)2.96285988
43Short 1st metacarpal (HP:0010034)2.94294280
44Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.94294280
45Abnormality of nucleobase metabolism (HP:0010932)2.94216593
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.94130285
47Confusion (HP:0001289)2.91442659
48Ketoacidosis (HP:0001993)2.84536862
49Systemic lupus erythematosus (HP:0002725)2.84297523
50Delayed CNS myelination (HP:0002188)2.83038853
51Metabolic acidosis (HP:0001942)2.81607971
52Steatorrhea (HP:0002570)2.79042495
53Abnormality of serum amino acid levels (HP:0003112)2.78992013
54Myositis (HP:0100614)2.74280434
55Abnormality of the 1st metacarpal (HP:0010009)2.73377444
56Myocardial infarction (HP:0001658)2.73331234
57Abnormality of purine metabolism (HP:0004352)2.69563307
58Lethargy (HP:0001254)2.68032248
59Hepatocellular carcinoma (HP:0001402)2.67632700
60Glomerulonephritis (HP:0000099)2.65398039
61Panhypogammaglobulinemia (HP:0003139)2.62201709
62Recurrent abscess formation (HP:0002722)2.60847004
63Acanthocytosis (HP:0001927)2.57667363
64Vascular calcification (HP:0004934)2.55975467
65Severe visual impairment (HP:0001141)2.55689138
66Skin nodule (HP:0200036)2.54474559
67Recurrent bacterial skin infections (HP:0005406)2.53706163
68Cerebral edema (HP:0002181)2.53342498
69Orchitis (HP:0100796)2.51908829
70Hemiplegia (HP:0002301)2.50514219
71Amyloidosis (HP:0011034)2.49498208
72Esophageal varix (HP:0002040)2.48507344
73Decreased central vision (HP:0007663)2.46678312
74Decreased circulating renin level (HP:0003351)2.46642948
75Menorrhagia (HP:0000132)2.45325890
76Eczematoid dermatitis (HP:0000976)2.44432285
77Optic neuritis (HP:0100653)2.41457846
78Retrobulbar optic neuritis (HP:0100654)2.41457846
79Visual hallucinations (HP:0002367)2.41395958
80Hypoglycemic seizures (HP:0002173)2.40509882
81Conjunctival hamartoma (HP:0100780)2.39634615
82Elevated erythrocyte sedimentation rate (HP:0003565)2.39255474
83Recurrent fungal infections (HP:0002841)2.39127468
84Gingival bleeding (HP:0000225)2.38861352
85Agitation (HP:0000713)2.34479906
86Progressive cerebellar ataxia (HP:0002073)2.33950582
87Stomatitis (HP:0010280)2.31330382
88Neonatal onset (HP:0003623)2.27873301
89Bone cyst (HP:0012062)2.27832260
90Cardiovascular calcification (HP:0011915)2.27749506
91Pigmentary retinal degeneration (HP:0001146)2.27455360
92Short phalanx of the thumb (HP:0009660)2.27013534
93Pancreatitis (HP:0001733)2.25492515
94Generalized aminoaciduria (HP:0002909)2.23365726
95Porencephaly (HP:0002132)2.23199695
96Gout (HP:0001997)2.22890554
97Spastic diplegia (HP:0001264)2.22463441
98Late onset (HP:0003584)2.21476609
99Irritability (HP:0000737)2.21062698
100Hypochromic microcytic anemia (HP:0004840)2.20995334
101Alkalosis (HP:0001948)2.19880509
102Abnormal gallbladder morphology (HP:0012437)2.18912476
103Abnormal rod and cone electroretinograms (HP:0008323)2.17606443
104Cholelithiasis (HP:0001081)2.15899969
105Thrombophlebitis (HP:0004418)2.15332710
106Vomiting (HP:0002013)2.14249610
107Methylmalonic aciduria (HP:0012120)2.13389635
108Abnormal gallbladder physiology (HP:0012438)2.12963432
109Cholecystitis (HP:0001082)2.12963432
110Mitral stenosis (HP:0001718)2.12608095
111Sensorimotor neuropathy (HP:0007141)2.10268425
112Hypertriglyceridemia (HP:0002155)2.09705303
113Abnormality of glycolipid metabolism (HP:0010969)2.08912857
114Abnormality of liposaccharide metabolism (HP:0010968)2.08912857
115Abnormality of glycosphingolipid metabolism (HP:0004343)2.08912857
116Congenital stationary night blindness (HP:0007642)2.06602990
117Mediastinal lymphadenopathy (HP:0100721)2.06256676
118Hypochromic anemia (HP:0001931)2.06054232
119Hemorrhage of the eye (HP:0011885)2.04809474
120Malnutrition (HP:0004395)2.04426838
121Abnormality of B cell number (HP:0010975)2.03801507
122Abnormality of macrophages (HP:0004311)2.03055191
123Short femoral neck (HP:0100864)2.01627336
124Abnormality of binocular vision (HP:0011514)2.01615527
125Diplopia (HP:0000651)2.01615527
126Abnormality of the vitamin B12 metabolism (HP:0004341)2.00837380
127Abnormality of the nasal septum (HP:0000419)1.99924449
128Recurrent gram-negative bacterial infections (HP:0005420)1.97882018
129Hydroxyprolinuria (HP:0003080)1.97690496
130Abnormality of proline metabolism (HP:0010907)1.97690496
131Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97688391
132Petechiae (HP:0000967)1.97187550
133Abnormality of DNA repair (HP:0003254)1.97117124
134Meningitis (HP:0001287)1.97057737
135Opisthotonus (HP:0002179)1.96835940
136Abnormal cartilage morphology (HP:0002763)1.96825135
137Nephritis (HP:0000123)1.96698742
138Ventricular fibrillation (HP:0001663)1.94468358
139Methylmalonic acidemia (HP:0002912)1.93863781
140Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.93767710
141Absent thumb (HP:0009777)1.93634109
142Abnormality of iron homeostasis (HP:0011031)1.93537593
143Encephalitis (HP:0002383)1.91517960
144Chorioretinal atrophy (HP:0000533)1.91482236
145Brushfield spots (HP:0001088)1.91442214
146Hypoplasia of the thymus (HP:0000778)1.91047569
147Hyperinsulinemic hypoglycemia (HP:0000825)1.90970019
148Abnormality of vitamin B metabolism (HP:0004340)1.89969903
149Enlarged kidneys (HP:0000105)1.89834832
150Attenuation of retinal blood vessels (HP:0007843)1.89461488
151Increased neuronal autofluorescent lipopigment (HP:0002074)1.89140547
152Dynein arm defect of respiratory motile cilia (HP:0012255)1.87883001
153Absent/shortened dynein arms (HP:0200106)1.87883001
154Anorexia (HP:0002039)1.86911531
155Poikilocytosis (HP:0004447)1.86554158
156Recurrent skin infections (HP:0001581)1.85498782
157Carpal bone hypoplasia (HP:0001498)1.84919837
158Hamartoma of the eye (HP:0010568)1.84769817
159Purpura (HP:0000979)1.84308925
160Pustule (HP:0200039)1.82880943
161Abnormality of transition element cation homeostasis (HP:0011030)1.82641884
162Hemoptysis (HP:0002105)1.82634432
163Abnormality of vitamin metabolism (HP:0100508)1.82566600
164Pancreatic cysts (HP:0001737)1.81804405
165Abnormality of the costochondral junction (HP:0000919)1.81448168
166Pulmonary infiltrates (HP:0002113)1.80640297
167Elevated hepatic transaminases (HP:0002910)1.80392670
168Abnormality of polysaccharide metabolism (HP:0011012)1.79708079
169Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79708079
170Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79708079
171Abnormality of the gallbladder (HP:0005264)1.79451689
172Rickets (HP:0002748)1.79439593
173Chronic obstructive pulmonary disease (HP:0006510)1.78887142
174Obstructive lung disease (HP:0006536)1.78887142
175Leukocytosis (HP:0001974)1.78778899
176Renal cortical cysts (HP:0000803)1.78769983
177Increased purine levels (HP:0004368)1.78683459
178Hyperuricemia (HP:0002149)1.78683459
179Symptomatic seizures (HP:0011145)1.78380121
180Abnormal delayed hypersensitivity skin test (HP:0002963)1.77858502

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.37125798
2ERN14.83136357
3FGFR43.55871398
4SIK13.46008695
5ACVR1B3.03203222
6ADRBK22.82351524
7RIPK42.78365467
8MST1R2.66115291
9TIE12.63505415
10TAOK32.39059301
11INSRR2.30160218
12PKN22.21584503
13PRKD22.21383832
14KDR2.20407078
15TGFBR22.15957460
16TRIB31.94336111
17TLK11.86522270
18TNK21.85705568
19CAMK1D1.74431548
20NEK91.74156922
21ERBB41.71060657
22PIK3CA1.68977604
23TXK1.66630473
24TBK11.64563908
25SYK1.64501584
26TYK21.62811655
27MAP2K41.61915703
28PIK3CG1.53817461
29FRK1.49028944
30FLT31.45386906
31MAP2K31.40239875
32MAP3K71.39642829
33MAPK111.39533703
34FES1.38404759
35PTK61.37389803
36MUSK1.36863407
37ABL21.24588157
38EPHB11.24131221
39IRAK41.22718369
40MYLK1.19700320
41JAK21.18059886
42RIPK11.17242096
43TGFBR11.17100376
44PINK11.14717204
45ITK1.13584951
46PRKAA21.08779883
47IKBKE1.07500392
48GRK71.05343623
49MAP2K61.03706397
50MAP2K21.02940404
51MAP3K141.00324513
52CSK0.99813978
53JAK10.97987598
54DAPK20.97490879
55NLK0.96971838
56MAPK120.95869438
57HCK0.95106815
58EPHA30.93964703
59LCK0.90507567
60GRK50.89165334
61MATK0.87199077
62TAOK10.87034386
63MAPK40.86540112
64CAMK1G0.84205020
65BMPR1B0.84007377
66PRKG20.83719824
67LATS10.81977701
68AKT30.81054088
69GRK10.77326949
70NUAK10.74381359
71MET0.72568405
72GRK60.70059910
73WNK40.68891310
74MAP4K10.68224084
75RPS6KA60.67745978
76HIPK20.67453802
77PRKACG0.67088764
78MAP3K110.65498041
79PDPK10.65265997
80CDK60.64829384
81ZAK0.64792788
82MAP2K10.64773769
83MAPKAPK30.64056972
84MAPK150.63874683
85CAMKK20.63423304
86ADRBK10.63016546
87FGFR20.62638558
88CSF1R0.62185248
89MAP3K10.59450567
90MAP4K20.59157302
91ERBB20.58764821
92IRAK30.58516023
93MAP3K30.57974940
94FGR0.57489743
95PDK10.57245200
96SGK20.56646200
97EPHB20.56074790
98PRKCZ0.54395198
99IGF1R0.53294103
100CAMK2G0.52406016
101IRAK10.52283148
102FGFR30.52142586
103MAPK70.51444314
104GSK3A0.50598723
105JAK30.49898986
106TNIK0.49207580
107MARK30.48888980
108OXSR10.48511562
109RPS6KL10.48466870
110RPS6KC10.48466870
111SGK4940.48049505
112SGK2230.48049505
113STK110.47392783
114PTK2B0.46118287
115SIK20.45211136
116MAPK130.44991394
117PRKAA10.44955658
118PIM10.44302434
119PRKD10.42781609
120CSNK1G10.42307074
121CDK90.41737636
122FYN0.41593566
123KIT0.40983213
124PDGFRA0.40869275
125DAPK30.40767671
126SGK10.40132966
127IKBKB0.39933997
128SGK30.38919537
129NME20.38854193
130DYRK1B0.38103543
131RET0.37526098
132TEC0.37062327
133MAP3K130.36342379
134BTK0.35668824
135ZAP700.35547927
136DDR20.31723491
137BLK0.31471304
138EGFR0.30967650
139PRKCA0.29005179
140MAP3K20.26991452
141PRKCQ0.26799177
142LYN0.26176098
143MAPK30.24074328
144CAMK40.23530956
145CAMKK10.23267155
146PTK20.21239790

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.15201885
2Nitrogen metabolism_Homo sapiens_hsa009103.51580859
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.44018952
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.01803079
5Arginine biosynthesis_Homo sapiens_hsa002202.87290426
6Complement and coagulation cascades_Homo sapiens_hsa046102.70337698
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.59017689
8Fatty acid degradation_Homo sapiens_hsa000712.55565606
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.54890836
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.54512071
11Tryptophan metabolism_Homo sapiens_hsa003802.54349679
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.41193129
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.34327959
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.27535008
15Renin-angiotensin system_Homo sapiens_hsa046142.26603056
16Butanoate metabolism_Homo sapiens_hsa006502.19385529
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.05227627
18PPAR signaling pathway_Homo sapiens_hsa033202.04235884
19Sulfur metabolism_Homo sapiens_hsa009202.02779726
20Peroxisome_Homo sapiens_hsa041462.01696016
21Propanoate metabolism_Homo sapiens_hsa006402.01086969
22* Chemical carcinogenesis_Homo sapiens_hsa052042.00718341
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.00670840
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95086949
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.94104801
26Staphylococcus aureus infection_Homo sapiens_hsa051501.89616828
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.88857982
28Caffeine metabolism_Homo sapiens_hsa002321.86169628
29Histidine metabolism_Homo sapiens_hsa003401.83654865
30Asthma_Homo sapiens_hsa053101.82944992
31Fatty acid metabolism_Homo sapiens_hsa012121.82266855
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.72367821
33Primary immunodeficiency_Homo sapiens_hsa053401.70545524
34beta-Alanine metabolism_Homo sapiens_hsa004101.68624692
35Retinol metabolism_Homo sapiens_hsa008301.67338162
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61270448
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53094047
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52665950
39Graft-versus-host disease_Homo sapiens_hsa053321.52640688
40Phenylalanine metabolism_Homo sapiens_hsa003601.51186051
41Bile secretion_Homo sapiens_hsa049761.50397680
42Allograft rejection_Homo sapiens_hsa053301.47568188
43Selenocompound metabolism_Homo sapiens_hsa004501.47455698
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46920730
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40515223
46Autoimmune thyroid disease_Homo sapiens_hsa053201.34702541
47Tyrosine metabolism_Homo sapiens_hsa003501.34374889
48Pyruvate metabolism_Homo sapiens_hsa006201.33098324
49Starch and sucrose metabolism_Homo sapiens_hsa005001.31511034
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.30364116
51Fat digestion and absorption_Homo sapiens_hsa049751.29565451
52Fatty acid elongation_Homo sapiens_hsa000621.27171712
53Sulfur relay system_Homo sapiens_hsa041221.26825320
54ABC transporters_Homo sapiens_hsa020101.23615597
55Other glycan degradation_Homo sapiens_hsa005111.15354067
56Systemic lupus erythematosus_Homo sapiens_hsa053221.14852356
57Carbon metabolism_Homo sapiens_hsa012001.14558912
58Leishmaniasis_Homo sapiens_hsa051401.11734644
59Folate biosynthesis_Homo sapiens_hsa007901.11705849
60Hematopoietic cell lineage_Homo sapiens_hsa046401.11091791
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09028739
62Biosynthesis of amino acids_Homo sapiens_hsa012301.08372602
63Type I diabetes mellitus_Homo sapiens_hsa049401.06554200
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99676256
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98478365
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96945101
67Osteoclast differentiation_Homo sapiens_hsa043800.96915692
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95547597
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.95494742
70Steroid biosynthesis_Homo sapiens_hsa001000.94460404
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85997982
72Tuberculosis_Homo sapiens_hsa051520.84835833
73Arginine and proline metabolism_Homo sapiens_hsa003300.84386608
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83537292
75Glycerolipid metabolism_Homo sapiens_hsa005610.80388887
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.79012691
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78638626
78Vitamin digestion and absorption_Homo sapiens_hsa049770.78335585
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.70838587
80Glutathione metabolism_Homo sapiens_hsa004800.68755630
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67511561
82Pentose phosphate pathway_Homo sapiens_hsa000300.66729723
83Antigen processing and presentation_Homo sapiens_hsa046120.65426562
84Lysine degradation_Homo sapiens_hsa003100.65402580
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62629928
86Ether lipid metabolism_Homo sapiens_hsa005650.61223174
87Vitamin B6 metabolism_Homo sapiens_hsa007500.60302318
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59374575
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56699547
90Fatty acid biosynthesis_Homo sapiens_hsa000610.56371667
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55164077
92Rheumatoid arthritis_Homo sapiens_hsa053230.55104250
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54967039
94B cell receptor signaling pathway_Homo sapiens_hsa046620.50765758
95Metabolic pathways_Homo sapiens_hsa011000.47886651
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47646737
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.47046910
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45817868
99Lysosome_Homo sapiens_hsa041420.45255217
100Taste transduction_Homo sapiens_hsa047420.44919873
101Fructose and mannose metabolism_Homo sapiens_hsa000510.44589792
102Renin secretion_Homo sapiens_hsa049240.43963329
103One carbon pool by folate_Homo sapiens_hsa006700.40699160
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40531264
105Nicotine addiction_Homo sapiens_hsa050330.39887390
106Galactose metabolism_Homo sapiens_hsa000520.39731049
107Linoleic acid metabolism_Homo sapiens_hsa005910.39557136
108Phototransduction_Homo sapiens_hsa047440.35151823
109Type II diabetes mellitus_Homo sapiens_hsa049300.34568904
110Morphine addiction_Homo sapiens_hsa050320.32492368
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32108326
112Dorso-ventral axis formation_Homo sapiens_hsa043200.30369742
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29394115
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.28066993
115Prion diseases_Homo sapiens_hsa050200.26048329
116Insulin resistance_Homo sapiens_hsa049310.24027176
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20078527
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.18582916
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08929587
120Glucagon signaling pathway_Homo sapiens_hsa049220.05213163
121AMPK signaling pathway_Homo sapiens_hsa041520.03931947
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.03381124
123Ovarian steroidogenesis_Homo sapiens_hsa049130.01214597
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1965239
125Parkinsons disease_Homo sapiens_hsa05012-0.1962494
126Regulation of autophagy_Homo sapiens_hsa04140-0.1940643
127Alzheimers disease_Homo sapiens_hsa05010-0.1897257
128Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1861137
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1775062
130Mineral absorption_Homo sapiens_hsa04978-0.1674283
131Oxidative phosphorylation_Homo sapiens_hsa00190-0.1666130
132Malaria_Homo sapiens_hsa05144-0.1653208
133RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1646162
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.1564962
135Pertussis_Homo sapiens_hsa05133-0.1482459
136Hepatitis C_Homo sapiens_hsa05160-0.1271432
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1184116
138Insulin signaling pathway_Homo sapiens_hsa04910-0.0873871
139African trypanosomiasis_Homo sapiens_hsa05143-0.0629397
140Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0400392
141Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0077659

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