SUDS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.61174287
2nuclear pore organization (GO:0006999)6.05947382
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.31522567
4L-phenylalanine metabolic process (GO:0006558)5.31522567
5L-phenylalanine catabolic process (GO:0006559)5.15514064
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.15514064
7lysine catabolic process (GO:0006554)5.14196237
8lysine metabolic process (GO:0006553)5.14196237
9alpha-linolenic acid metabolic process (GO:0036109)5.05186183
10pre-miRNA processing (GO:0031054)4.99588625
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.92376391
12cysteine metabolic process (GO:0006534)4.77205630
13pore complex assembly (GO:0046931)4.73071136
14kynurenine metabolic process (GO:0070189)4.70029634
15mitotic sister chromatid cohesion (GO:0007064)4.68083658
16urea metabolic process (GO:0019627)4.67420634
17urea cycle (GO:0000050)4.67420634
18glyoxylate metabolic process (GO:0046487)4.59871306
19serine family amino acid catabolic process (GO:0009071)4.59278591
20sulfur amino acid catabolic process (GO:0000098)4.57215436
21aromatic amino acid family catabolic process (GO:0009074)4.56186386
22paraxial mesoderm development (GO:0048339)4.54058123
23dicarboxylic acid biosynthetic process (GO:0043650)4.36326747
24regulation of cholesterol homeostasis (GO:2000188)4.32672600
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.27263475
26nitrogen cycle metabolic process (GO:0071941)4.26778061
27negative regulation of fibrinolysis (GO:0051918)4.16098678
28bile acid biosynthetic process (GO:0006699)4.15369548
292-oxoglutarate metabolic process (GO:0006103)4.10731117
30amino-acid betaine metabolic process (GO:0006577)4.07691688
31glycine metabolic process (GO:0006544)4.04856797
32negative regulation of sterol transport (GO:0032372)4.04359005
33negative regulation of cholesterol transport (GO:0032375)4.04359005
34tryptophan catabolic process (GO:0006569)4.03589842
35indole-containing compound catabolic process (GO:0042436)4.03589842
36indolalkylamine catabolic process (GO:0046218)4.03589842
37glutamate metabolic process (GO:0006536)4.03211491
38regulation of fatty acid beta-oxidation (GO:0031998)4.03090130
39homocysteine metabolic process (GO:0050667)4.01625524
40high-density lipoprotein particle remodeling (GO:0034375)3.97503540
41regulation of triglyceride catabolic process (GO:0010896)3.95189441
42positive regulation of fatty acid beta-oxidation (GO:0032000)3.93966781
43aspartate family amino acid catabolic process (GO:0009068)3.93225605
44cellular modified amino acid catabolic process (GO:0042219)3.88819383
45ethanol oxidation (GO:0006069)3.86193968
46regulation of centriole replication (GO:0046599)3.84166427
47complement activation, alternative pathway (GO:0006957)3.83957856
48peptidyl-glutamic acid carboxylation (GO:0017187)3.80233724
49protein carboxylation (GO:0018214)3.80233724
50regulation of protein activation cascade (GO:2000257)3.74808352
51cellular ketone body metabolic process (GO:0046950)3.72339988
52regulation of meiosis I (GO:0060631)3.72305802
53centriole replication (GO:0007099)3.72102286
54tryptophan metabolic process (GO:0006568)3.70115864
55alpha-amino acid catabolic process (GO:1901606)3.69622622
56short-chain fatty acid metabolic process (GO:0046459)3.67269641
57serine family amino acid metabolic process (GO:0009069)3.66529209
58regulation of fibrinolysis (GO:0051917)3.66347259
59acetyl-CoA metabolic process (GO:0006084)3.63478578
60regulation of histone H3-K9 methylation (GO:0051570)3.59529590
61positive regulation of lipid catabolic process (GO:0050996)3.59230856
62bile acid metabolic process (GO:0008206)3.59013203
63heterochromatin organization (GO:0070828)3.57609229
64fatty acid transmembrane transport (GO:1902001)3.53419921
65regulation of complement activation (GO:0030449)3.52103623
66reverse cholesterol transport (GO:0043691)3.50863024
67drug catabolic process (GO:0042737)3.49848311
68plasma lipoprotein particle clearance (GO:0034381)3.49776793
69cellular amino acid catabolic process (GO:0009063)3.49131970
70positive regulation of histone H3-K4 methylation (GO:0051571)3.46503757
71triglyceride homeostasis (GO:0070328)3.45737494
72acylglycerol homeostasis (GO:0055090)3.45737494
73valine metabolic process (GO:0006573)3.37996793
74carnitine shuttle (GO:0006853)3.37605395
75regulation of centrosome duplication (GO:0010824)3.36166956
76fatty acid beta-oxidation (GO:0006635)3.36142241
77plasma lipoprotein particle remodeling (GO:0034369)3.34535687
78protein-lipid complex remodeling (GO:0034368)3.34535687
79macromolecular complex remodeling (GO:0034367)3.34535687
80phospholipid homeostasis (GO:0055091)3.33858242
81phospholipid efflux (GO:0033700)3.32723418
82regulation of centrosome cycle (GO:0046605)3.30662224
83protein localization to kinetochore (GO:0034501)3.29213523
84positive regulation of chromosome segregation (GO:0051984)3.27938954
85positive regulation of triglyceride metabolic process (GO:0090208)3.27773310
86regulation of chromatin silencing (GO:0031935)3.27299978
87aromatic amino acid family metabolic process (GO:0009072)3.24608220
884-hydroxyproline metabolic process (GO:0019471)3.24425094
89regulation of cholesterol esterification (GO:0010872)3.24297923
90fatty acid oxidation (GO:0019395)3.23899737
91carnitine metabolic process (GO:0009437)3.21436168
92regulation of mitotic spindle checkpoint (GO:1903504)3.20845493
93regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.20845493
94drug transmembrane transport (GO:0006855)3.19561248
95regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.19452104
96positive regulation of fatty acid oxidation (GO:0046321)3.18495032
97ketone body metabolic process (GO:1902224)3.17805085
98regulation of fatty acid oxidation (GO:0046320)3.17513745
99establishment of integrated proviral latency (GO:0075713)3.16841866
100regulation of DNA endoreduplication (GO:0032875)3.16620805
101negative regulation of fatty acid biosynthetic process (GO:0045717)3.16416476
102lipid oxidation (GO:0034440)3.16303495
103chromatin remodeling at centromere (GO:0031055)3.15620713
104exogenous drug catabolic process (GO:0042738)3.13531958
105positive regulation of mitotic sister chromatid separation (GO:1901970)3.11773201
106positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.11773201
107positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.11773201
108centriole assembly (GO:0098534)3.10679181
109ethanol metabolic process (GO:0006067)3.10219411
110nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.08303358
111non-recombinational repair (GO:0000726)3.08142243
112double-strand break repair via nonhomologous end joining (GO:0006303)3.08142243
113fatty acid homeostasis (GO:0055089)3.07044763
114plasma lipoprotein particle assembly (GO:0034377)3.05197198
115fatty acid catabolic process (GO:0009062)3.04884784
116monocarboxylic acid catabolic process (GO:0072329)3.04262036
117organic acid catabolic process (GO:0016054)3.03879875
118carboxylic acid catabolic process (GO:0046395)3.03879875
119regulation of DNA methylation (GO:0044030)3.03058495
120bile acid and bile salt transport (GO:0015721)3.03026156
121regulation of posttranscriptional gene silencing (GO:0060147)3.02923100
122regulation of gene silencing by miRNA (GO:0060964)3.02923100
123regulation of gene silencing by RNA (GO:0060966)3.02923100
124tricarboxylic acid metabolic process (GO:0072350)3.02737072
125positive regulation of triglyceride biosynthetic process (GO:0010867)3.02574338
126cholesterol homeostasis (GO:0042632)3.02188892
127regulation of fatty acid biosynthetic process (GO:0042304)3.01672347
128sterol homeostasis (GO:0055092)3.01344367
129genitalia morphogenesis (GO:0035112)3.01219973
130protein-lipid complex assembly (GO:0065005)3.00969073
131negative regulation of translation, ncRNA-mediated (GO:0040033)3.00838851
132regulation of translation, ncRNA-mediated (GO:0045974)3.00838851
133negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.00838851
134benzene-containing compound metabolic process (GO:0042537)2.99500843
135amino-acid betaine transport (GO:0015838)2.99492157
136carnitine transport (GO:0015879)2.99492157
137serine family amino acid biosynthetic process (GO:0009070)2.99437953
138sister chromatid cohesion (GO:0007062)2.99380072
139regulation of RNA export from nucleus (GO:0046831)2.99078633
140regulation of helicase activity (GO:0051095)2.97478006
141imidazole-containing compound metabolic process (GO:0052803)2.94437173
142negative regulation of DNA repair (GO:0045738)2.94411909
143somatic diversification of immune receptors via somatic mutation (GO:0002566)2.94340370
144somatic hypermutation of immunoglobulin genes (GO:0016446)2.94340370
145negative regulation of DNA-dependent DNA replication (GO:2000104)2.93593210
146nodal signaling pathway (GO:0038092)2.92496437
147CENP-A containing nucleosome assembly (GO:0034080)2.90985065
148DNA unwinding involved in DNA replication (GO:0006268)2.89277947
149DNA replication checkpoint (GO:0000076)2.88256357
150meiotic chromosome segregation (GO:0045132)2.87835198
151DNA duplex unwinding (GO:0032508)2.87276132
152embryonic foregut morphogenesis (GO:0048617)2.84207822
153sister chromatid segregation (GO:0000819)2.82706271
154protein localization to chromosome, centromeric region (GO:0071459)2.82441532
155DNA geometric change (GO:0032392)2.81799024
156single strand break repair (GO:0000012)2.79746227
157regulation of gene silencing (GO:0060968)2.77823529
158positive regulation of cell cycle G2/M phase transition (GO:1902751)2.77570545
159positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.77570545
160DNA double-strand break processing (GO:0000729)2.77237104
161peptidyl-lysine dimethylation (GO:0018027)2.76654890
162oocyte development (GO:0048599)2.76413689
163notochord development (GO:0030903)2.76367743
164protein-DNA complex disassembly (GO:0032986)2.75439111
165nucleosome disassembly (GO:0006337)2.75439111
166negative regulation of histone methylation (GO:0031061)2.74942819
167regulation of nuclear cell cycle DNA replication (GO:0033262)2.71947345
168telomere maintenance via telomerase (GO:0007004)2.71646873
169somite rostral/caudal axis specification (GO:0032525)2.70529075
170NLS-bearing protein import into nucleus (GO:0006607)2.69448901
171DNA methylation involved in gamete generation (GO:0043046)2.69173199
172positive regulation of cell cycle checkpoint (GO:1901978)2.69126539
173histone H3-K36 demethylation (GO:0070544)2.68995643
174DNA replication-independent nucleosome organization (GO:0034724)2.68592928
175DNA replication-independent nucleosome assembly (GO:0006336)2.68592928
176DNA strand elongation involved in DNA replication (GO:0006271)2.65319118
177mitotic nuclear envelope disassembly (GO:0007077)2.64432054
178dorsal/ventral axis specification (GO:0009950)2.62618346
179intestinal epithelial cell development (GO:0060576)2.62501251
180histone exchange (GO:0043486)2.62460155
181gene silencing by RNA (GO:0031047)2.62311151
182regulation of translational termination (GO:0006449)2.60937153
183regulation of chromosome segregation (GO:0051983)2.60725998
184meiotic cell cycle (GO:0051321)2.59785080
185regulation of sister chromatid cohesion (GO:0007063)2.55808069
186ATP-dependent chromatin remodeling (GO:0043044)2.55406990
187negative regulation of mRNA metabolic process (GO:1903312)2.55179263
188chromatin assembly (GO:0031497)2.55142943
189bundle of His cell to Purkinje myocyte communication (GO:0086069)2.54921839
190hippo signaling (GO:0035329)2.54794703
191regulation of spindle checkpoint (GO:0090231)2.52963283
192DNA strand elongation (GO:0022616)2.52766012
193regulation of mitotic sister chromatid segregation (GO:0033047)2.52300777
194regulation of sister chromatid segregation (GO:0033045)2.52300777
195regulation of mitotic sister chromatid separation (GO:0010965)2.52300777
196positive regulation of SMAD protein import into nucleus (GO:0060391)2.51973108
197ncRNA catabolic process (GO:0034661)2.51082494
198DNA replication initiation (GO:0006270)2.50584553

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.45292229
2E2F7_22180533_ChIP-Seq_HELA_Human6.38086738
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.26770702
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.90908664
5SALL1_21062744_ChIP-ChIP_HESCs_Human4.61132622
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.59488502
7* LXR_22158963_ChIP-Seq_LIVER_Mouse4.21672262
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.47005622
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.32012242
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.10337056
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.88010333
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.80636021
13ZNF263_19887448_ChIP-Seq_K562_Human2.66271000
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.64628974
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.56725798
16AR_21909140_ChIP-Seq_LNCAP_Human2.45177561
17FUS_26573619_Chip-Seq_HEK293_Human2.31206241
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28962063
19CLOCK_20551151_ChIP-Seq_293T_Human2.24715082
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20967317
21LXR_22292898_ChIP-Seq_THP-1_Human2.09542041
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08282665
23* PADI4_21655091_ChIP-ChIP_MCF-7_Human2.05147497
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.00770987
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99736327
26EWS_26573619_Chip-Seq_HEK293_Human1.99526875
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.96203710
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.90237236
29MYC_22102868_ChIP-Seq_BL_Human1.90135507
30KDM2B_26808549_Chip-Seq_DND41_Human1.90092339
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87935733
32PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.82282315
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.81019860
34* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79542583
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78786294
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77722979
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76736395
38TAF15_26573619_Chip-Seq_HEK293_Human1.73910809
39RACK7_27058665_Chip-Seq_MCF-7_Human1.71201863
40* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70801144
41IGF1R_20145208_ChIP-Seq_DFB_Human1.70420928
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68467824
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68267937
44* TCF7_22412390_ChIP-Seq_EML_Mouse1.67091374
45TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.66941516
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66714998
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63330558
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62837859
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61879706
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.61500325
51FOXM1_26456572_ChIP-Seq_MCF-7_Human1.61216787
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59161746
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57636275
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57602246
55TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.55006476
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54897947
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54269814
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.51638471
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.50834408
60ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.50677588
61* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49915185
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.49414448
63CREB1_26743006_Chip-Seq_LNCaP_Human1.49407607
64P300_19829295_ChIP-Seq_ESCs_Human1.49402659
65ELK1_19687146_ChIP-ChIP_HELA_Human1.48423030
66KDM2B_26808549_Chip-Seq_K562_Human1.47244024
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.45951511
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44454746
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43235813
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.40867798
71ATF3_27146783_Chip-Seq_COLON_Human1.40089583
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38362512
73* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.38248692
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.37928086
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37083620
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.36855070
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36583763
78FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.35314437
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.33647438
80SOX2_27498859_Chip-Seq_STOMACH_Mouse1.33165459
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32303773
82EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31988251
83CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31432943
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.28528762
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28149769
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27475537
87FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.27073121
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27009374
89* CHD1_26751641_Chip-Seq_LNCaP_Human1.26357906
90VDR_21846776_ChIP-Seq_THP-1_Human1.25818286
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23637566
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23618944
93* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23202655
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22859973
95MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22322863
96P68_20966046_ChIP-Seq_HELA_Human1.21901678
97GBX2_23144817_ChIP-Seq_PC3_Human1.19392264
98TBX3_20139965_ChIP-Seq_ESCs_Mouse1.18645255
99ER_23166858_ChIP-Seq_MCF-7_Human1.18449539
100KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.18153880
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.18053086
102SOX2_16153702_ChIP-ChIP_HESCs_Human1.17671674
103TBX20_22328084_ChIP-Seq_HEART_Mouse1.17658999
104TBX20_22080862_ChIP-Seq_HEART_Mouse1.17658999
105STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17603773
106FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17504776
107ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17217010
108MYC_18555785_ChIP-Seq_MESCs_Mouse1.17118418
109TBX3_20139965_ChIP-Seq_MESCs_Mouse1.16984984
110* STAT3_23295773_ChIP-Seq_U87_Human1.16860427
111GATA6_25053715_ChIP-Seq_YYC3_Human1.16587872
112ZNF274_21170338_ChIP-Seq_K562_Hela1.14936317
113TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14681816
114RUNX1_27514584_Chip-Seq_MCF-7_Human1.12076925
115* TCF4_23295773_ChIP-Seq_U87_Human1.10987605
116PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10903612
117STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10845931
118ERG_21242973_ChIP-ChIP_JURKAT_Human1.10650850
119HNF4A_19822575_ChIP-Seq_HepG2_Human1.09365947
120CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09171924
121AHR_22903824_ChIP-Seq_MCF-7_Human1.09161652
122KDM5A_27292631_Chip-Seq_BREAST_Human1.07963494
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07912386
124PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05046814
125CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04728123
126ARNT_22903824_ChIP-Seq_MCF-7_Human1.04374777
127SMAD3_21741376_ChIP-Seq_EPCs_Human1.03738021
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03685010
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03643884
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03643884
131SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03160842
132RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02986895
133EGR1_19374776_ChIP-ChIP_THP-1_Human1.02090360
134FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02029734
135E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01191865
136FOXM1_23109430_ChIP-Seq_U2OS_Human1.00699425
137PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00113169
138SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99944570
139UTX_26944678_Chip-Seq_JUKART_Human0.99928951
140TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99707772
141GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99475362
142UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99194321
143CBP_20019798_ChIP-Seq_JUKART_Human0.99035031
144IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99035031
145SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98884016
146SMC4_20622854_ChIP-Seq_HELA_Human0.98712476
147POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98625904
148* SMAD4_21799915_ChIP-Seq_A2780_Human0.98405360
149GATA1_19941826_ChIP-Seq_K562_Human0.97894124
150ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97823092
151* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97794562
152NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97742669
153MAF_26560356_Chip-Seq_TH1_Human0.97703423
154BCOR_27268052_Chip-Seq_Bcells_Human0.97612310
155DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97596544
156ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97576635
157ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97539043
158TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96860131
159DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96392860
160TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95976266
161* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95592137
162NCOR1_26117541_ChIP-Seq_K562_Human0.95449377
163TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95427094
164SA1_27219007_Chip-Seq_ERYTHROID_Human0.95277496
165SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95150348
166* FOXA1_25552417_ChIP-Seq_VCAP_Human0.94941651
167GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.94847902
168SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94396180
169TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94283829
170NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94227527
171KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92829219
172KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92829219
173KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92829219
174WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92564459
175MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92137757
176BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91797288
177TP63_22573176_ChIP-Seq_HFKS_Human0.91639785
178NFE2_27457419_Chip-Seq_LIVER_Mouse0.91073423
179* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90335328
180MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90110963
181AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89716278
182CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88616719
183PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87733535
184GATA1_19941827_ChIP-Seq_MEL_Mouse0.87252568
185YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87088617
186* CTCF_21964334_Chip-Seq_Bcells_Human0.86861184
187* CTCF_27219007_Chip-Seq_Bcells_Human0.86670078
188TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.86474261
189* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.85954509
190NANOG_18555785_Chip-Seq_ESCs_Mouse0.84894034
191EST1_17652178_ChIP-ChIP_JURKAT_Human0.84488939
192ELF1_20517297_ChIP-Seq_JURKAT_Human0.84112896
193TET1_21451524_ChIP-Seq_MESCs_Mouse0.83664477
194* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82605477
195FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81728655
196ESR1_21235772_ChIP-Seq_MCF-7_Human0.78836999
197SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78753580
198PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78355449

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.48459182
2MP0005360_urolithiasis6.22300024
3MP0005085_abnormal_gallbladder_physiolo4.96748857
4MP0005365_abnormal_bile_salt4.61237082
5MP0008057_abnormal_DNA_replication4.59778247
6MP0003890_abnormal_embryonic-extraembry3.93815737
7MP0008875_abnormal_xenobiotic_pharmacok3.52160309
8MP0003705_abnormal_hypodermis_morpholog3.51885340
9MP0003252_abnormal_bile_duct3.45085983
10MP0009840_abnormal_foam_cell3.06261898
11MP0010329_abnormal_lipoprotein_level3.00202619
12MP0010234_abnormal_vibrissa_follicle2.87696665
13MP0008877_abnormal_DNA_methylation2.85351355
14MP0005083_abnormal_biliary_tract2.84016151
15MP0003693_abnormal_embryo_hatching2.68186418
16MP0010094_abnormal_chromosome_stability2.67470348
17MP0004957_abnormal_blastocyst_morpholog2.65966786
18MP0003806_abnormal_nucleotide_metabolis2.65436291
19MP0003941_abnormal_skin_development2.36967433
20MP0005332_abnormal_amino_acid2.29469571
21MP0003191_abnormal_cellular_cholesterol2.27903816
22MP0001666_abnormal_nutrient_absorption2.17114014
23MP0002009_preneoplasia2.15644018
24* MP0003111_abnormal_nucleus_morphology2.13340978
25MP0003718_maternal_effect2.01328590
26MP0010678_abnormal_skin_adnexa2.00473559
27MP0003121_genomic_imprinting1.98354343
28MP0003123_paternal_imprinting1.96988623
29MP0000609_abnormal_liver_physiology1.96573413
30MP0004130_abnormal_muscle_cell1.95775996
31MP0003136_yellow_coat_color1.91723661
32MP0004185_abnormal_adipocyte_glucose1.91696694
33MP0000383_abnormal_hair_follicle1.90531424
34MP0008058_abnormal_DNA_repair1.89944475
35MP0003937_abnormal_limbs/digits/tail_de1.84126816
36MP0003787_abnormal_imprinting1.81601773
37MP0003300_gastrointestinal_ulcer1.81020473
38MP0002118_abnormal_lipid_homeostasis1.80678151
39MP0001188_hyperpigmentation1.79879266
40MP0002837_dystrophic_cardiac_calcinosis1.74544079
41MP0008932_abnormal_embryonic_tissue1.74289505
42* MP0003077_abnormal_cell_cycle1.71878011
43MP0000427_abnormal_hair_cycle1.70564532
44MP0002084_abnormal_developmental_patter1.70066292
45MP0003195_calcinosis1.69823435
46MP0004019_abnormal_vitamin_homeostasis1.67730921
47MP0002138_abnormal_hepatobiliary_system1.67255576
48MP0005666_abnormal_adipose_tissue1.64908056
49MP0005319_abnormal_enzyme/_coenzyme1.63299480
50MP0001293_anophthalmia1.54815194
51MP0008961_abnormal_basal_metabolism1.49141108
52MP0001672_abnormal_embryogenesis/_devel1.46864026
53MP0005380_embryogenesis_phenotype1.46864026
54MP0003567_abnormal_fetal_cardiomyocyte1.45859201
55MP0009703_decreased_birth_body1.45150809
56MP0002085_abnormal_embryonic_tissue1.36535310
57MP0001697_abnormal_embryo_size1.35931913
58MP0009643_abnormal_urine_homeostasis1.35324671
59MP0002796_impaired_skin_barrier1.30278978
60MP0004381_abnormal_hair_follicle1.30039445
61MP0009697_abnormal_copulation1.29434054
62MP0005248_abnormal_Harderian_gland1.28998214
63MP0003646_muscle_fatigue1.28870601
64MP0004197_abnormal_fetal_growth/weight/1.28373897
65MP0005584_abnormal_enzyme/coenzyme_acti1.27412373
66MP0002233_abnormal_nose_morphology1.26136263
67MP0003984_embryonic_growth_retardation1.25763516
68MP0002088_abnormal_embryonic_growth/wei1.25558823
69MP0000377_abnormal_hair_follicle1.23584735
70MP0000350_abnormal_cell_proliferation1.23037967
71MP0003868_abnormal_feces_composition1.22409409
72MP0003303_peritoneal_inflammation1.21659480
73MP0005076_abnormal_cell_differentiation1.18348494
74* MP0010307_abnormal_tumor_latency1.18114991
75MP0005395_other_phenotype1.16283431
76MP0003119_abnormal_digestive_system1.15495992
77MP0000566_synostosis1.14784992
78MP0002971_abnormal_brown_adipose1.12853959
79MP0000428_abnormal_craniofacial_morphol1.11002392
80MP0004087_abnormal_muscle_fiber1.10920020
81MP0005375_adipose_tissue_phenotype1.09723113
82MP0002160_abnormal_reproductive_system1.08867971
83MP0000751_myopathy1.08332378
84MP0000604_amyloidosis1.07988122
85MP0002086_abnormal_extraembryonic_tissu1.06658097
86MP0008007_abnormal_cellular_replicative1.06555896
87MP0003656_abnormal_erythrocyte_physiolo1.06215103
88MP0001929_abnormal_gametogenesis1.05485577
89MP0002653_abnormal_ependyma_morphology1.05373760
90MP0005330_cardiomyopathy1.03208924
91MP0001849_ear_inflammation1.02455147
92MP0000598_abnormal_liver_morphology1.02433394
93MP0001286_abnormal_eye_development1.02372093
94MP0005075_abnormal_melanosome_morpholog1.02347859
95MP0002697_abnormal_eye_size0.99960150
96MP0005379_endocrine/exocrine_gland_phen0.99854328
97* MP0002080_prenatal_lethality0.99144822
98MP0004043_abnormal_pH_regulation0.98481136
99MP0002269_muscular_atrophy0.98054857
100MP0010352_gastrointestinal_tract_polyps0.96503476
101MP0003566_abnormal_cell_adhesion0.96232409
102MP0000579_abnormal_nail_morphology0.95902698
103MP0002751_abnormal_autonomic_nervous0.95655676
104MP0003122_maternal_imprinting0.95602030
105MP0003329_amyloid_beta_deposits0.95266221
106MP0000569_abnormal_digit_pigmentation0.94103523
107MP0006072_abnormal_retinal_apoptosis0.93600869
108MP0002210_abnormal_sex_determination0.93304666
109MP0009053_abnormal_anal_canal0.93144311
110MP0005187_abnormal_penis_morphology0.92651043
111MP0003861_abnormal_nervous_system0.92351290
112MP0005220_abnormal_exocrine_pancreas0.90129433
113MP0003786_premature_aging0.89396565
114MP0002938_white_spotting0.89345788
115MP0008789_abnormal_olfactory_epithelium0.89271569
116MP0000653_abnormal_sex_gland0.88893578
117MP0004233_abnormal_muscle_weight0.88546051
118MP0002078_abnormal_glucose_homeostasis0.88345522
119MP0000432_abnormal_head_morphology0.87775821
120MP0005670_abnormal_white_adipose0.87604224
121MP0004147_increased_porphyrin_level0.86795776
122MP0001145_abnormal_male_reproductive0.86430940
123MP0010630_abnormal_cardiac_muscle0.86325034
124MP0002111_abnormal_tail_morphology0.86144645
125MP0000747_muscle_weakness0.85957445
126MP0000631_abnormal_neuroendocrine_gland0.85346661
127MP0004133_heterotaxia0.85182821
128MP0002254_reproductive_system_inflammat0.85008635
129MP0009672_abnormal_birth_weight0.83571461
130MP0002163_abnormal_gland_morphology0.83421347
131MP0002909_abnormal_adrenal_gland0.83267187
132MP0001984_abnormal_olfaction0.83214197
133MP0003943_abnormal_hepatobiliary_system0.83183663
134MP0005499_abnormal_olfactory_system0.83111923
135MP0005394_taste/olfaction_phenotype0.83111923
136MP0001765_abnormal_ion_homeostasis0.83075928
137MP0001756_abnormal_urination0.82146995
138MP0005636_abnormal_mineral_homeostasis0.82086346
139MP0000647_abnormal_sebaceous_gland0.81506936
140MP0006036_abnormal_mitochondrial_physio0.79667919
141MP0004084_abnormal_cardiac_muscle0.78158446
142MP0001299_abnormal_eye_distance/0.77737416
143MP0000462_abnormal_digestive_system0.77701698
144MP0005167_abnormal_blood-brain_barrier0.76977479
145MP0003699_abnormal_female_reproductive0.75486222
146MP0002098_abnormal_vibrissa_morphology0.75000785
147MP0005171_absent_coat_pigmentation0.73255746
148MP0003935_abnormal_craniofacial_develop0.73083994
149MP0002396_abnormal_hematopoietic_system0.72175774
150MP0004036_abnormal_muscle_relaxation0.71660640
151MP0005451_abnormal_body_composition0.70519670
152MP0003221_abnormal_cardiomyocyte_apopto0.70455787
153MP0005501_abnormal_skin_physiology0.69672582
154MP0005334_abnormal_fat_pad0.69279599
155MP0003075_altered_response_to0.68121557
156MP0003453_abnormal_keratinocyte_physiol0.68101025
157MP0009642_abnormal_blood_homeostasis0.67839386
158MP0002136_abnormal_kidney_physiology0.67076160
159MP0000537_abnormal_urethra_morphology0.65861445
160MP0004858_abnormal_nervous_system0.64564235
161MP0005535_abnormal_body_temperature0.64168746
162MP0000003_abnormal_adipose_tissue0.62166329
163MP0008874_decreased_physiological_sensi0.61288302
164MP0000750_abnormal_muscle_regeneration0.59537128
165MP0005647_abnormal_sex_gland0.57891424
166MP0009763_increased_sensitivity_to0.55637424
167MP0005166_decreased_susceptibility_to0.55305701
168MP0004510_myositis0.55303580
169MP0004264_abnormal_extraembryonic_tissu0.54709570
170MP0009278_abnormal_bone_marrow0.54145997
171MP0002970_abnormal_white_adipose0.53715737
172MP0000733_abnormal_muscle_development0.52005746
173MP0001764_abnormal_homeostasis0.51954376
174MP0002089_abnormal_postnatal_growth/wei0.51559916
175MP0009115_abnormal_fat_cell0.50981889
176MP0002877_abnormal_melanocyte_morpholog0.50864526
177MP0003011_delayed_dark_adaptation0.50608783
178MP0005385_cardiovascular_system_phenoty0.50374328
179MP0001544_abnormal_cardiovascular_syste0.50374328
180MP0005266_abnormal_metabolism0.49715316
181MP0005023_abnormal_wound_healing0.48558131
182MP0000759_abnormal_skeletal_muscle0.48523065
183MP0004947_skin_inflammation0.46404173
184MP0001730_embryonic_growth_arrest0.46235928
185MP0002928_abnormal_bile_duct0.45284116
186MP0009780_abnormal_chondrocyte_physiolo0.45233300

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.51334199
2Intrahepatic cholestasis (HP:0001406)4.71103138
3Abnormality of monocarboxylic acid metabolism (HP:0010996)4.70370533
4Xanthomatosis (HP:0000991)4.65175936
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.36865617
6Hypobetalipoproteinemia (HP:0003563)3.97178016
7Hyperammonemia (HP:0001987)3.78766800
8Ketosis (HP:0001946)3.76649640
9Hyperglycinuria (HP:0003108)3.72705356
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.66784694
11Hyperglycinemia (HP:0002154)3.62627792
12Chronic bronchitis (HP:0004469)3.56660593
13Complement deficiency (HP:0004431)3.50034545
14Papillary thyroid carcinoma (HP:0002895)3.48117223
15Hyperlipoproteinemia (HP:0010980)3.47527421
16Abnormality of glutamine family amino acid metabolism (HP:0010902)3.47408445
17Abnormality of glycine metabolism (HP:0010895)3.46913666
18Abnormality of serine family amino acid metabolism (HP:0010894)3.46913666
19Chromsome breakage (HP:0040012)3.46639213
20Abnormality of the Achilles tendon (HP:0005109)3.31115342
21Hypolipoproteinemia (HP:0010981)3.26306369
22Hypoalphalipoproteinemia (HP:0003233)3.15723712
23Hypoglycemic coma (HP:0001325)3.11682084
24Ketoacidosis (HP:0001993)3.10423558
25Gout (HP:0001997)3.08344295
26Epidermoid cyst (HP:0200040)3.07591212
27Colon cancer (HP:0003003)3.06925232
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.03089798
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.96473068
30Spastic diplegia (HP:0001264)2.91666713
31Breast carcinoma (HP:0003002)2.89822177
32Nephroblastoma (Wilms tumor) (HP:0002667)2.89752431
33Volvulus (HP:0002580)2.88553198
34Achilles tendon contracture (HP:0001771)2.87711881
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.86453825
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.86045958
37Rhabdomyosarcoma (HP:0002859)2.84968062
38Abnormality of the lower motor neuron (HP:0002366)2.84722238
39Abnormality of chromosome stability (HP:0003220)2.83433137
40Myoglobinuria (HP:0002913)2.82404148
41Embryonal renal neoplasm (HP:0011794)2.77808655
42Prolonged partial thromboplastin time (HP:0003645)2.73745072
43Ependymoma (HP:0002888)2.73733807
44Curly hair (HP:0002212)2.69957843
45Abnormality of the common coagulation pathway (HP:0010990)2.66494642
46Glioma (HP:0009733)2.65508799
47Abnormality of complement system (HP:0005339)2.63234393
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.58626775
49Absent/shortened dynein arms (HP:0200106)2.58626775
50Abnormality of fatty-acid metabolism (HP:0004359)2.55561894
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.55544140
52Abnormality of the astrocytes (HP:0100707)2.54342148
53Astrocytoma (HP:0009592)2.54342148
54Abnormality of purine metabolism (HP:0004352)2.53975267
55Hypercholesterolemia (HP:0003124)2.53843480
56Rhinitis (HP:0012384)2.51018805
57Vertebral arch anomaly (HP:0008438)2.50303785
58Global brain atrophy (HP:0002283)2.45155852
59Gastrointestinal carcinoma (HP:0002672)2.43752415
60Malignant gastrointestinal tract tumors (HP:0006749)2.43752415
61Myocardial infarction (HP:0001658)2.43640865
62Abnormal respiratory motile cilium physiology (HP:0012261)2.40348001
63Neonatal onset (HP:0003623)2.40178257
64Gonadotropin excess (HP:0000837)2.39899831
65Lymphangioma (HP:0100764)2.38114734
66Meckel diverticulum (HP:0002245)2.37869973
67Hepatocellular carcinoma (HP:0001402)2.37840636
68Skin nodule (HP:0200036)2.36812085
69Right ventricular cardiomyopathy (HP:0011663)2.36504389
70Thyroid carcinoma (HP:0002890)2.36070498
71Abnormality of nucleobase metabolism (HP:0010932)2.35660681
72Pseudobulbar signs (HP:0002200)2.33578692
73Cholelithiasis (HP:0001081)2.32565779
74Malnutrition (HP:0004395)2.31859026
75Back pain (HP:0003418)2.30462148
76Abnormality of the ileum (HP:0001549)2.28226368
77Abnormality of abdominal situs (HP:0011620)2.28022325
78Abdominal situs inversus (HP:0003363)2.28022325
79Abnormality of the labia minora (HP:0012880)2.27418317
80Biliary tract neoplasm (HP:0100574)2.26607206
81Reticulocytosis (HP:0001923)2.24919170
82Late onset (HP:0003584)2.24403052
83Hyporeflexia of lower limbs (HP:0002600)2.24270849
84Delayed CNS myelination (HP:0002188)2.24077753
85Abnormality of the preputium (HP:0100587)2.23547719
86Medulloblastoma (HP:0002885)2.22478009
87Aqueductal stenosis (HP:0002410)2.20561679
88Ectopic kidney (HP:0000086)2.20395450
89Cholecystitis (HP:0001082)2.18850285
90Abnormal gallbladder physiology (HP:0012438)2.18850285
91Fat malabsorption (HP:0002630)2.16804813
92Tubulointerstitial nephritis (HP:0001970)2.16673619
93Joint hemorrhage (HP:0005261)2.16587464
94Sudden death (HP:0001699)2.16577792
95Abnormal ciliary motility (HP:0012262)2.14147406
96Abnormal respiratory epithelium morphology (HP:0012253)2.13632300
97Abnormal respiratory motile cilium morphology (HP:0005938)2.13632300
98Deep philtrum (HP:0002002)2.13206503
99Dysmetric saccades (HP:0000641)2.09741662
100Lip pit (HP:0100267)2.08168613
101Abnormality of methionine metabolism (HP:0010901)2.07743729
102Abnormal gallbladder morphology (HP:0012437)2.07697846
103Hypoplastic labia majora (HP:0000059)2.07210593
104Neoplasm of striated muscle (HP:0009728)2.06879872
105Neoplasm of the adrenal cortex (HP:0100641)2.06712200
106Exercise-induced myalgia (HP:0003738)2.06354703
107Abnormal cartilage morphology (HP:0002763)2.06171910
108Polycythemia (HP:0001901)2.05958579
109Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.05206210
110Hyperbilirubinemia (HP:0002904)2.04283722
111Absent eyebrow (HP:0002223)2.03824678
112Hyperinsulinemic hypoglycemia (HP:0000825)2.01701529
113Atrioventricular block (HP:0001678)2.01573985
114Abnormality of the intrinsic pathway (HP:0010989)2.00547444
115Abnormality of pyrimidine metabolism (HP:0004353)1.99031508
116Hydroxyprolinuria (HP:0003080)1.98785464
117Abnormality of proline metabolism (HP:0010907)1.98785464
118Bronchiectasis (HP:0002110)1.98240912
119Rhabdomyolysis (HP:0003201)1.97879788
120Bundle branch block (HP:0011710)1.97480344
121Status epilepticus (HP:0002133)1.97237524
122Intestinal atresia (HP:0011100)1.96810539
123Hyperuricemia (HP:0002149)1.96357803
124Increased purine levels (HP:0004368)1.96357803
125Ventricular fibrillation (HP:0001663)1.96205414
126Metabolic acidosis (HP:0001942)1.95963457
127Hyperacusis (HP:0010780)1.95258557
128Hamartoma of the eye (HP:0010568)1.95132835
129Exercise-induced muscle cramps (HP:0003710)1.94867217
130Abnormality of serum amino acid levels (HP:0003112)1.94576629
131Small intestinal stenosis (HP:0012848)1.92900430
132Duodenal stenosis (HP:0100867)1.92900430
133Poikilocytosis (HP:0004447)1.92574645
134Facial cleft (HP:0002006)1.92111023
135Anal stenosis (HP:0002025)1.91944612
136Absent radius (HP:0003974)1.91492429
137Amelogenesis imperfecta (HP:0000705)1.90871244
138Distal upper limb amyotrophy (HP:0007149)1.90333317
139Upper limb amyotrophy (HP:0009129)1.90333317
140Abnormal lung lobation (HP:0002101)1.90213585
141Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89634998
142Dicarboxylic aciduria (HP:0003215)1.89634998
143Esophageal varix (HP:0002040)1.87793358
144Acanthocytosis (HP:0001927)1.86674316
145Conjunctival hamartoma (HP:0100780)1.86502549
146Difficulty running (HP:0009046)1.85915966
147Abnormality of the duodenum (HP:0002246)1.84835871
148Uterine neoplasm (HP:0010784)1.83663558
149Hemorrhage of the eye (HP:0011885)1.82572389
150Transitional cell carcinoma of the bladder (HP:0006740)1.81984745
151Cystic hygroma (HP:0000476)1.81614626
152Labial hypoplasia (HP:0000066)1.81605200
153Sloping forehead (HP:0000340)1.80602993
154Sensorimotor neuropathy (HP:0007141)1.79945881
155Adenoma sebaceum (HP:0009720)1.79681753
156Angiofibromas (HP:0010615)1.79681753
157Turricephaly (HP:0000262)1.79337045
158Hand muscle atrophy (HP:0009130)1.77434655
159Limb hypertonia (HP:0002509)1.76668947
160Increased connective tissue (HP:0009025)1.76448106
161Hypoplastic female external genitalia (HP:0012815)1.75947664
162Abnormal biliary tract morphology (HP:0012440)1.75536756
163Cortical dysplasia (HP:0002539)1.75057507
164Embryonal neoplasm (HP:0002898)1.74936776
165Cerebral aneurysm (HP:0004944)1.74793835
166Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74713317
167Cafe-au-lait spot (HP:0000957)1.74494639
168Vascular calcification (HP:0004934)1.74194490
169Abnormality of the labia majora (HP:0012881)1.74069260
170Abnormal hair whorl (HP:0010721)1.73076177
171Carpal bone hypoplasia (HP:0001498)1.73057166
172Abnormality of endocrine pancreas physiology (HP:0012093)1.73026254
173Abnormality of the pancreatic islet cells (HP:0006476)1.73026254
174Mitral stenosis (HP:0001718)1.72133535
175Chronic hepatic failure (HP:0100626)1.71669574
176Overlapping toe (HP:0001845)1.70373397
177Pancreatic islet-cell hyperplasia (HP:0004510)1.69673059
178Multiple enchondromatosis (HP:0005701)1.69607811
179Abnormal biliary tract physiology (HP:0012439)1.69450152
180Bile duct proliferation (HP:0001408)1.69450152
181Truncal obesity (HP:0001956)1.69177654
182Absent forearm bone (HP:0003953)1.68338412
183Aplasia involving forearm bones (HP:0009822)1.68338412
184Abnormality of the renal medulla (HP:0100957)1.67109619
185Pancreatic cysts (HP:0001737)1.66001751
186Bladder neoplasm (HP:0009725)1.65898062
187Bladder carcinoma (HP:0002862)1.65898062
188Myelomeningocele (HP:0002475)1.65285548
189Abnormality of chromosome segregation (HP:0002916)1.64827360
190Neoplasm of the small intestine (HP:0100833)1.64612784
191Cutaneous finger syndactyly (HP:0010554)1.63548380
192Bifid tongue (HP:0010297)1.62935762
193Broad alveolar ridges (HP:0000187)1.61869297
194Nephronophthisis (HP:0000090)1.61619316
195Abnormality of the proximal phalanges of the hand (HP:0009834)1.60661655
196Cutaneous syndactyly (HP:0012725)1.60513370
197Leiomyosarcoma (HP:0100243)1.60483997

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.98499864
2PKN24.29123439
3MAP3K103.23826791
4STK38L2.94228113
5BMPR1B2.84073879
6TTK2.74336257
7EEF2K2.51234609
8ERN12.47544460
9ACVR1B2.43071712
10CDC72.38046791
11MKNK22.37972207
12NUAK12.37956169
13RIPK12.27193408
14BCKDK2.17775394
15SIK12.16212909
16BRD42.11030525
17TTN2.10223651
18TNIK2.09310664
19PTK62.08837255
20MKNK11.94590641
21FGFR41.89797712
22TSSK61.88103130
23ZAK1.85594701
24TAF11.84496723
25KSR21.74991422
26NLK1.73928717
27PLK41.71711658
28SRPK11.68202179
29MST41.67898438
30ICK1.66114337
31PDGFRA1.64311062
32PDK41.62727365
33PDK31.62727365
34LMTK21.60849473
35EIF2AK31.60088887
36TAOK11.58292018
37ERBB31.55060494
38CDK121.52508390
39STK241.46252088
40MAP3K91.45684450
41PLK31.44292786
42LATS11.40891024
43BRSK21.36356110
44STK391.34468023
45TYRO31.34150991
46SCYL21.31616028
47NEK11.29656014
48TRIM281.29382163
49WNK31.26036042
50STK381.24279417
51MAP3K71.24183978
52PNCK1.23958492
53LRRK21.22270819
54AKT31.21896467
55PRKD31.19343312
56PBK1.18243957
57RET1.18121731
58ALK1.17924095
59BMX1.17330484
60DAPK21.16703163
61OXSR11.16622988
62GRK61.11649845
63PASK1.09627153
64CAMK1D1.08829429
65MAP3K41.08518805
66PLK11.07306677
67CAMKK11.03127235
68EIF2AK11.02541875
69MELK1.01898931
70CAMK1G1.01810124
71MAPK111.01099665
72MAP2K40.98801862
73BCR0.98052085
74MTOR0.95529460
75LATS20.95108026
76ATM0.94984082
77MAP3K20.94052162
78SIK20.93538819
79YES10.92642698
80WEE10.90345035
81ATR0.87857563
82CDK60.87083894
83PTK20.86382132
84JAK20.85797109
85DMPK0.84872763
86NEK20.83945884
87PAK60.82949115
88CHEK20.82940036
89FLT30.82842512
90PDPK10.82826079
91MAP2K30.81003675
92PDK10.77957188
93CDK40.77492863
94DDR20.76970007
95NEK60.76509537
96WNK40.75822236
97DYRK1B0.75685942
98BUB10.74267543
99MAP3K110.73286598
100TAOK30.72995113
101MAP2K20.71572796
102MAP3K80.71409010
103IRAK10.70553197
104PHKG20.69373250
105PHKG10.69373250
106CHEK10.69280163
107STK40.69048110
108EPHB10.68162796
109CDK70.67519211
110STK110.66920473
111STK100.66251921
112RPS6KA40.64483066
113PRKAA10.60242856
114CASK0.59961954
115PDGFRB0.59242928
116PDK20.58376811
117SGK30.58040252
118MAP3K10.57791421
119DAPK30.55251162
120PRKCH0.55023016
121PRKAA20.54904793
122MET0.54847435
123TYK20.54088793
124PRKD10.54016253
125SMG10.53396486
126EIF2AK20.53296380
127JAK10.53148530
128TGFBR10.52302495
129CDC42BPA0.52205648
130MST1R0.52161307
131MAP4K10.52109834
132STK30.51361111
133FGFR20.51308160
134CSNK1E0.50573842
135ERBB20.50028454
136PAK20.49467201
137CDK10.48249465
138* CDK20.47880138
139RPS6KB10.46967499
140MAP2K10.46622424
141PAK40.45342491
142WNK10.44827451
143ILK0.44453670
144MAP3K30.43919570
145PRKCI0.43532220
146MUSK0.43212735
147CSNK1D0.42563855
148SGK20.40377890
149FGFR10.40357937
150KSR10.40285091
151MAPKAPK30.40133886
152AURKB0.39712984
153AKT20.39668912
154RPS6KA10.39615045
155FGFR30.39069731
156FRK0.38960274
157NTRK10.38682309
158FER0.38661763
159CAMK40.38549237
160PRKDC0.38267647
161PAK30.37852424
162BRSK10.37680581
163RPS6KB20.37592662
164PLK20.35532309
165DYRK30.35020959
166CSNK1G10.32866931
167CDK90.29557886
168CSNK1A1L0.29256740
169IRAK20.27984352

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.24475319
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.92854388
3Non-homologous end-joining_Homo sapiens_hsa034503.68826001
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.42187770
5Arginine biosynthesis_Homo sapiens_hsa002203.18465850
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.94357269
7Mismatch repair_Homo sapiens_hsa034302.79730410
8Fatty acid degradation_Homo sapiens_hsa000712.71511067
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68639924
10Cell cycle_Homo sapiens_hsa041102.57998138
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.36258269
12RNA transport_Homo sapiens_hsa030132.32658168
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29895514
14Tryptophan metabolism_Homo sapiens_hsa003802.27808390
15DNA replication_Homo sapiens_hsa030302.19861193
16Basal transcription factors_Homo sapiens_hsa030222.19612961
17Fanconi anemia pathway_Homo sapiens_hsa034602.06718276
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.04952918
19Propanoate metabolism_Homo sapiens_hsa006402.02648568
20PPAR signaling pathway_Homo sapiens_hsa033202.01717734
21mRNA surveillance pathway_Homo sapiens_hsa030152.00708665
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.99672721
23Butanoate metabolism_Homo sapiens_hsa006501.99316478
24Bile secretion_Homo sapiens_hsa049761.91688001
25Fatty acid metabolism_Homo sapiens_hsa012121.86365751
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.85370903
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.85340180
28Complement and coagulation cascades_Homo sapiens_hsa046101.79702174
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.76336473
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.76236228
31Adherens junction_Homo sapiens_hsa045201.75165912
32Homologous recombination_Homo sapiens_hsa034401.75152423
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.65354033
34RNA degradation_Homo sapiens_hsa030181.64454586
35Nucleotide excision repair_Homo sapiens_hsa034201.64271527
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.61866955
37Carbon metabolism_Homo sapiens_hsa012001.60402081
38Pyruvate metabolism_Homo sapiens_hsa006201.49223823
39Biosynthesis of amino acids_Homo sapiens_hsa012301.47731517
40Hippo signaling pathway_Homo sapiens_hsa043901.47665352
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46796179
42Lysine degradation_Homo sapiens_hsa003101.46576352
43Spliceosome_Homo sapiens_hsa030401.45467917
44beta-Alanine metabolism_Homo sapiens_hsa004101.37671980
45Colorectal cancer_Homo sapiens_hsa052101.37438574
46Selenocompound metabolism_Homo sapiens_hsa004501.35996908
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.34680493
48Caffeine metabolism_Homo sapiens_hsa002321.34549686
49Oocyte meiosis_Homo sapiens_hsa041141.29738106
50Peroxisome_Homo sapiens_hsa041461.29530928
51Basal cell carcinoma_Homo sapiens_hsa052171.28581172
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28457264
53Fat digestion and absorption_Homo sapiens_hsa049751.27413792
54p53 signaling pathway_Homo sapiens_hsa041151.27156701
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.24981634
56Tight junction_Homo sapiens_hsa045301.20973106
57Base excision repair_Homo sapiens_hsa034101.16043618
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14510537
59TGF-beta signaling pathway_Homo sapiens_hsa043501.14480665
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14241701
61Phenylalanine metabolism_Homo sapiens_hsa003601.12741520
62Wnt signaling pathway_Homo sapiens_hsa043101.10198488
63MicroRNAs in cancer_Homo sapiens_hsa052061.10104229
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09934327
65Starch and sucrose metabolism_Homo sapiens_hsa005001.08345471
66Prostate cancer_Homo sapiens_hsa052151.07758398
67Chemical carcinogenesis_Homo sapiens_hsa052041.07548303
68Sulfur relay system_Homo sapiens_hsa041221.06358209
69Sphingolipid metabolism_Homo sapiens_hsa006001.05354968
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01806102
71ABC transporters_Homo sapiens_hsa020101.00619573
72Drug metabolism - other enzymes_Homo sapiens_hsa009831.00583937
73Cysteine and methionine metabolism_Homo sapiens_hsa002701.00109658
74Histidine metabolism_Homo sapiens_hsa003400.99524601
75Phototransduction_Homo sapiens_hsa047440.97411153
76Hedgehog signaling pathway_Homo sapiens_hsa043400.96742675
77Staphylococcus aureus infection_Homo sapiens_hsa051500.94114653
78Fatty acid biosynthesis_Homo sapiens_hsa000610.92791797
79Insulin resistance_Homo sapiens_hsa049310.90731525
80Inositol phosphate metabolism_Homo sapiens_hsa005620.90472691
81Glycerolipid metabolism_Homo sapiens_hsa005610.87759017
82Steroid biosynthesis_Homo sapiens_hsa001000.87577296
83Protein export_Homo sapiens_hsa030600.85405762
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84925924
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.84862405
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.82802476
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82370173
88Retinol metabolism_Homo sapiens_hsa008300.81070263
89Circadian rhythm_Homo sapiens_hsa047100.79247658
90Tyrosine metabolism_Homo sapiens_hsa003500.76897235
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75237057
92Glucagon signaling pathway_Homo sapiens_hsa049220.72905362
93Renal cell carcinoma_Homo sapiens_hsa052110.70712769
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68980578
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.68648533
96Pentose phosphate pathway_Homo sapiens_hsa000300.68401178
97Sulfur metabolism_Homo sapiens_hsa009200.64924677
98mTOR signaling pathway_Homo sapiens_hsa041500.63910694
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63070163
100Arginine and proline metabolism_Homo sapiens_hsa003300.62504903
101AMPK signaling pathway_Homo sapiens_hsa041520.62451239
102Bladder cancer_Homo sapiens_hsa052190.61642704
103Regulation of autophagy_Homo sapiens_hsa041400.61182635
104Insulin signaling pathway_Homo sapiens_hsa049100.60504550
105FoxO signaling pathway_Homo sapiens_hsa040680.60488051
106Long-term depression_Homo sapiens_hsa047300.60110947
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59150838
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59090888
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58548023
110Vitamin B6 metabolism_Homo sapiens_hsa007500.58313089
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55998652
112Pancreatic cancer_Homo sapiens_hsa052120.52290203
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52033958
114Taste transduction_Homo sapiens_hsa047420.51323442
115ErbB signaling pathway_Homo sapiens_hsa040120.49688913
116Type II diabetes mellitus_Homo sapiens_hsa049300.49332269
117Ether lipid metabolism_Homo sapiens_hsa005650.48559232
118One carbon pool by folate_Homo sapiens_hsa006700.47697407
119Choline metabolism in cancer_Homo sapiens_hsa052310.47453840
120Non-small cell lung cancer_Homo sapiens_hsa052230.47384474
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47128605
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43117018
123Melanogenesis_Homo sapiens_hsa049160.43020494
124Folate biosynthesis_Homo sapiens_hsa007900.42733899
125Melanoma_Homo sapiens_hsa052180.42023254
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.41422734
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41100691
128VEGF signaling pathway_Homo sapiens_hsa043700.40638041
129Fructose and mannose metabolism_Homo sapiens_hsa000510.40177112
130Purine metabolism_Homo sapiens_hsa002300.39442045
131Glioma_Homo sapiens_hsa052140.39077359
132Viral carcinogenesis_Homo sapiens_hsa052030.38272445
133Dorso-ventral axis formation_Homo sapiens_hsa043200.37646541
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36979249
135Prion diseases_Homo sapiens_hsa050200.36598334
136Ovarian steroidogenesis_Homo sapiens_hsa049130.36018526
137Chronic myeloid leukemia_Homo sapiens_hsa052200.35230758
138Pathways in cancer_Homo sapiens_hsa052000.35005758
139Estrogen signaling pathway_Homo sapiens_hsa049150.31739438
140Endometrial cancer_Homo sapiens_hsa052130.30963752
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25579971
142Thyroid hormone synthesis_Homo sapiens_hsa049180.24970063
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23322730
144Galactose metabolism_Homo sapiens_hsa000520.22379565
145Vitamin digestion and absorption_Homo sapiens_hsa049770.21621196
146Glutathione metabolism_Homo sapiens_hsa004800.20710140
147Aldosterone synthesis and secretion_Homo sapiens_hsa049250.19196746
148Proteoglycans in cancer_Homo sapiens_hsa052050.18606418
149Gastric acid secretion_Homo sapiens_hsa049710.17810183
150Amoebiasis_Homo sapiens_hsa051460.17239083
151Acute myeloid leukemia_Homo sapiens_hsa052210.17221205
152Thyroid cancer_Homo sapiens_hsa052160.15675243
153Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.13644669
154Fatty acid elongation_Homo sapiens_hsa000620.13623028
155Prolactin signaling pathway_Homo sapiens_hsa049170.13167201
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.12086280
157Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.11270215
158Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.09838518

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