SUCNR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which has known correlations to renal failure, diabetes and atherosclerosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.37481946
2L-phenylalanine catabolic process (GO:0006559)7.37481946
3L-phenylalanine metabolic process (GO:0006558)7.04447208
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.04447208
5aromatic amino acid family catabolic process (GO:0009074)6.68014799
6indole-containing compound catabolic process (GO:0042436)6.05998802
7indolalkylamine catabolic process (GO:0046218)6.05998802
8tryptophan catabolic process (GO:0006569)6.05998802
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.94968788
10kynurenine metabolic process (GO:0070189)5.84521295
11bile acid biosynthetic process (GO:0006699)5.82485518
12glyoxylate metabolic process (GO:0046487)5.80242663
13alpha-linolenic acid metabolic process (GO:0036109)5.77443664
14tryptophan metabolic process (GO:0006568)5.69218711
15neutrophil activation involved in immune response (GO:0002283)5.62619065
16cysteine metabolic process (GO:0006534)5.49314564
17sulfur amino acid catabolic process (GO:0000098)5.41678651
18positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)5.36608409
19urea metabolic process (GO:0019627)5.35874598
20urea cycle (GO:0000050)5.35874598
21cellular extravasation (GO:0045123)5.23295836
22complement activation, alternative pathway (GO:0006957)5.18816137
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.16079446
24serine family amino acid catabolic process (GO:0009071)5.09093482
25bile acid metabolic process (GO:0008206)5.07282713
26negative regulation of fibrinolysis (GO:0051918)5.06068906
27high-density lipoprotein particle remodeling (GO:0034375)5.04103562
28protein carboxylation (GO:0018214)4.99865252
29peptidyl-glutamic acid carboxylation (GO:0017187)4.99865252
30positive regulation of mast cell activation (GO:0033005)4.97500732
31nitrogen cycle metabolic process (GO:0071941)4.94726935
32glycosphingolipid catabolic process (GO:0046479)4.94173376
33regulation of protein activation cascade (GO:2000257)4.93820550
34regulation of fibrinolysis (GO:0051917)4.86899210
35lysine catabolic process (GO:0006554)4.85367029
36lysine metabolic process (GO:0006553)4.85367029
37aromatic amino acid family metabolic process (GO:0009072)4.84352097
38homocysteine metabolic process (GO:0050667)4.78953509
39positive regulation of mast cell activation involved in immune response (GO:0033008)4.77055165
40positive regulation of mast cell degranulation (GO:0043306)4.77055165
41regulation of triglyceride catabolic process (GO:0010896)4.67335855
42regulation of complement activation (GO:0030449)4.67001401
43eosinophil chemotaxis (GO:0048245)4.66861024
44amino-acid betaine metabolic process (GO:0006577)4.63358508
45tyrosine metabolic process (GO:0006570)4.62852141
46alpha-amino acid catabolic process (GO:1901606)4.61142478
47acylglycerol homeostasis (GO:0055090)4.54048736
48triglyceride homeostasis (GO:0070328)4.54048736
49eosinophil migration (GO:0072677)4.48791833
50oligosaccharide catabolic process (GO:0009313)4.46397976
51plasma lipoprotein particle remodeling (GO:0034369)4.44065520
52protein-lipid complex remodeling (GO:0034368)4.44065520
53macromolecular complex remodeling (GO:0034367)4.44065520
54cellular ketone body metabolic process (GO:0046950)4.43318397
55response to peptidoglycan (GO:0032494)4.43048822
56regulation of cholesterol esterification (GO:0010872)4.42862914
57glycolipid catabolic process (GO:0019377)4.42615313
58reverse cholesterol transport (GO:0043691)4.38778085
59plasma lipoprotein particle clearance (GO:0034381)4.37953676
60bile acid and bile salt transport (GO:0015721)4.34031236
61positive regulation of gamma-delta T cell activation (GO:0046645)4.32931570
62ethanol oxidation (GO:0006069)4.30980970
63coenzyme catabolic process (GO:0009109)4.30646349
64cellular amino acid catabolic process (GO:0009063)4.30090196
65negative regulation of sterol transport (GO:0032372)4.28602715
66negative regulation of cholesterol transport (GO:0032375)4.28602715
67glycine metabolic process (GO:0006544)4.28442433
68indolalkylamine metabolic process (GO:0006586)4.27915147
69angiotensin maturation (GO:0002003)4.21595972
70serine family amino acid metabolic process (GO:0009069)4.20992454
71phospholipid efflux (GO:0033700)4.19396144
72cellular glucuronidation (GO:0052695)4.19109050
73regulation of mast cell degranulation (GO:0043304)4.18297520
74amine catabolic process (GO:0009310)4.17529632
75cellular biogenic amine catabolic process (GO:0042402)4.17529632
76regulation of syncytium formation by plasma membrane fusion (GO:0060142)4.15588199
77glutamate metabolic process (GO:0006536)4.08600376
78benzene-containing compound metabolic process (GO:0042537)4.04826335
79imidazole-containing compound metabolic process (GO:0052803)4.04560929
80cellular modified amino acid catabolic process (GO:0042219)4.04455906
81acetyl-CoA metabolic process (GO:0006084)4.03676638
82short-chain fatty acid metabolic process (GO:0046459)4.02995032
83regulation of mast cell activation (GO:0033003)3.97527743
84ceramide catabolic process (GO:0046514)3.97107656
85drug catabolic process (GO:0042737)3.97071794
86positive regulation of leukocyte degranulation (GO:0043302)3.96362289
87regulation of mast cell activation involved in immune response (GO:0033006)3.96135510
88serine family amino acid biosynthetic process (GO:0009070)3.94748772
89dicarboxylic acid biosynthetic process (GO:0043650)3.89231154
90positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.88583720
91pinocytosis (GO:0006907)3.87178601
92aldehyde catabolic process (GO:0046185)3.86832045
93low-density lipoprotein particle remodeling (GO:0034374)3.85763914
94organic acid catabolic process (GO:0016054)3.85109301
95carboxylic acid catabolic process (GO:0046395)3.85109301
96ketone body metabolic process (GO:1902224)3.83364782
97positive regulation of lipid catabolic process (GO:0050996)3.82086883
98cholesterol efflux (GO:0033344)3.81864925
99neutrophil mediated immunity (GO:0002446)3.81135356
100negative regulation of interleukin-17 production (GO:0032700)3.80863329
101fatty acid beta-oxidation (GO:0006635)3.78512811
102urate metabolic process (GO:0046415)3.78309185
103drug transmembrane transport (GO:0006855)3.77327242
104arginine metabolic process (GO:0006525)3.76176606
105uronic acid metabolic process (GO:0006063)3.76156629
106glucuronate metabolic process (GO:0019585)3.76156629
107fatty acid oxidation (GO:0019395)3.75133166
108phospholipid homeostasis (GO:0055091)3.71267766
109positive regulation of B cell differentiation (GO:0045579)3.70465074
110valine metabolic process (GO:0006573)3.69489413
111lipid oxidation (GO:0034440)3.67948964
112plasma lipoprotein particle assembly (GO:0034377)3.67838784
113monocarboxylic acid catabolic process (GO:0072329)3.67483734
114positive regulation of fatty acid beta-oxidation (GO:0032000)3.67200593
115cytolysis (GO:0019835)3.67017890
116cellular response to thyroid hormone stimulus (GO:0097067)3.64712634
1172-oxoglutarate metabolic process (GO:0006103)3.63812057
118amino sugar catabolic process (GO:0046348)3.62567515
119fibrinolysis (GO:0042730)3.62549145
120positive regulation of bone remodeling (GO:0046852)3.61236612
121positive regulation of bone resorption (GO:0045780)3.61236612
122fatty acid catabolic process (GO:0009062)3.60850733
123cholesterol homeostasis (GO:0042632)3.60417204
124regulation of cholesterol homeostasis (GO:2000188)3.60345488
125cofactor catabolic process (GO:0051187)3.58742622
126negative regulation of lipase activity (GO:0060192)3.57836543
127sterol homeostasis (GO:0055092)3.55540924
128complement activation (GO:0006956)3.55338749
129aspartate family amino acid catabolic process (GO:0009068)3.54699448
130negative regulation of interleukin-12 production (GO:0032695)3.54383494
131regulation of leukocyte degranulation (GO:0043300)3.54349666
132regulation of myeloid leukocyte mediated immunity (GO:0002886)3.50615953
133granulocyte activation (GO:0036230)3.45880591
134G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.43275549
135modulation of growth of symbiont involved in interaction with host (GO:0044144)3.41254536
136regulation of growth of symbiont in host (GO:0044126)3.41254536
137negative regulation of growth of symbiont in host (GO:0044130)3.41254536
138negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.41254536
139osteoclast differentiation (GO:0030316)3.36575131
140neutrophil activation (GO:0042119)3.33139995
141response to thyroid hormone (GO:0097066)3.28853966
142G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.26974121
143positive regulation of cellular amide metabolic process (GO:0034250)3.23712248
144regulation of hypersensitivity (GO:0002883)3.21733720
145macrophage differentiation (GO:0030225)3.21599100
146detection of molecule of bacterial origin (GO:0032490)3.15108045
147respiratory burst (GO:0045730)3.14416191
148myeloid cell activation involved in immune response (GO:0002275)3.07928630
149adenosine receptor signaling pathway (GO:0001973)3.07235373
150positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.06669307
151positive regulation of regulated secretory pathway (GO:1903307)3.06202428
152lipopolysaccharide-mediated signaling pathway (GO:0031663)3.03218721
153regulation of T-helper 1 cell differentiation (GO:0045625)3.02599141
154myeloid leukocyte mediated immunity (GO:0002444)3.01360867
155regulation of platelet activation (GO:0010543)3.01243050
156cellular response to ethanol (GO:0071361)3.00196731
157adhesion of symbiont to host cell (GO:0044650)2.99383533
158virion attachment to host cell (GO:0019062)2.99383533
159negative regulation of erythrocyte differentiation (GO:0045647)2.98643193
160immunoglobulin mediated immune response (GO:0016064)2.95978784
161regulation of gamma-delta T cell activation (GO:0046643)2.94499345
162granulocyte chemotaxis (GO:0071621)2.93400265
163peptide catabolic process (GO:0043171)2.93349178
164regulation of tolerance induction (GO:0002643)2.91569856
165granulocyte migration (GO:0097530)2.90990236
166regulation of cholesterol storage (GO:0010885)2.90354662
167histamine secretion (GO:0001821)2.86842930
168lipoxygenase pathway (GO:0019372)2.84527278
169germinal center formation (GO:0002467)2.83672603
170leukocyte degranulation (GO:0043299)2.83417749
171thrombin receptor signaling pathway (GO:0070493)2.83354889
172response to muramyl dipeptide (GO:0032495)2.82395155
173macrophage activation involved in immune response (GO:0002281)2.81803379
174adhesion of symbiont to host (GO:0044406)2.80230351
175regulation of regulated secretory pathway (GO:1903305)2.78956821
176detection of other organism (GO:0098543)2.78677746
177dendritic cell differentiation (GO:0097028)2.78550173
178positive regulation of macrophage differentiation (GO:0045651)2.78538768
179positive regulation of type 2 immune response (GO:0002830)2.77441752
180regulation of T-helper 2 cell differentiation (GO:0045628)2.77403626
181regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.76497869
182regulation of T cell tolerance induction (GO:0002664)2.75965589
183positive regulation of monocyte chemotaxis (GO:0090026)2.75466091
184positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.75150666
185myeloid dendritic cell activation (GO:0001773)2.73915794
186regulation of gamma-delta T cell differentiation (GO:0045586)2.71691689
187purinergic receptor signaling pathway (GO:0035587)2.70705145
188positive regulation of antigen processing and presentation (GO:0002579)2.70310323
189regulation of monocyte differentiation (GO:0045655)2.68499311
190positive regulation by organism of defense response of other organism involved in symbiotic interact2.66278854
191modulation by symbiont of host immune response (GO:0052553)2.66278854
192positive regulation by symbiont of host defense response (GO:0052509)2.66278854
193modulation by symbiont of host defense response (GO:0052031)2.66278854
194modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.66278854
195modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.66278854
196positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.65659949
197detection of external biotic stimulus (GO:0098581)2.65243135
198regulation of integrin activation (GO:0033623)2.64568518
199production of molecular mediator involved in inflammatory response (GO:0002532)2.64515956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.19065772
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.03008637
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.72727022
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.38220568
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.01902305
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.05560862
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.72616194
8IRF8_21731497_ChIP-ChIP_J774_Mouse4.36152919
9IRF8_27001747_Chip-Seq_BMDM_Mouse4.13873707
10BP1_19119308_ChIP-ChIP_Hs578T_Human4.08968387
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.96154060
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.89460906
13MYB_21317192_ChIP-Seq_ERMYB_Mouse3.83617275
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.75829386
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.72467585
16* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.43693030
17SCL_19346495_ChIP-Seq_HPC-7_Human3.29392676
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.69683690
19SPI1_23547873_ChIP-Seq_NB4_Human2.62442486
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.54536352
21SPI1_23127762_ChIP-Seq_K562_Human2.53098079
22VDR_24787735_ChIP-Seq_THP-1_Human2.50997340
23VDR_24763502_ChIP-Seq_THP-1_Human2.49939915
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.48014053
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.42535327
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.34349620
27* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17296776
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.11630664
29TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06703328
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.03831638
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.00000854
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4033654
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.97982783
34PU_27001747_Chip-Seq_BMDM_Mouse1.97372261
35VDR_21846776_ChIP-Seq_THP-1_Human1.96101851
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.92997021
37CLOCK_20551151_ChIP-Seq_293T_Human1.92944619
38* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.92538302
39* RUNX1_22412390_ChIP-Seq_EML_Mouse1.86944449
40* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.83248545
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.77474331
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76889736
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74428480
44RUNX_20019798_ChIP-Seq_JUKART_Human1.72896629
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72712242
46MYB_26560356_Chip-Seq_TH2_Human1.72655558
47PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.71903153
48PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.71036409
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.62901843
50NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.62208979
51GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.60604143
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.60222616
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.52443425
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51770276
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.51138797
56GATA1_22025678_ChIP-Seq_K562_Human1.49006264
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.46547748
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.44274443
59HTT_18923047_ChIP-ChIP_STHdh_Human1.42497593
60HNF4A_19822575_ChIP-Seq_HepG2_Human1.40390319
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39915437
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38314859
63GATA3_27048872_Chip-Seq_THYMUS_Human1.34436244
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30564538
65TFEB_21752829_ChIP-Seq_HELA_Human1.27943234
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24752661
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24375015
68MYB_26560356_Chip-Seq_TH1_Human1.24141984
69PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20938761
70GATA3_26560356_Chip-Seq_TH2_Human1.19601959
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17884917
72MAF_26560356_Chip-Seq_TH1_Human1.17256671
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16962433
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15419620
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14679647
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13971232
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13661483
78RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13241664
79* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12694300
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08178244
81UTX_26944678_Chip-Seq_JUKART_Human1.07145156
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06574706
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05323262
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02869290
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01999274
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01090824
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98666924
88STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98044219
89SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97993649
90TCF7_22412390_ChIP-Seq_EML_Mouse0.93282573
91PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92894717
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90899307
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90653679
94IRF8_22096565_ChIP-ChIP_GC-B_Human0.90498473
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90130332
96SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89784530
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88284125
98KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87289791
99GATA4_25053715_ChIP-Seq_YYC3_Human0.86976850
100ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86712365
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85683263
102GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84482315
103NCOR1_26117541_ChIP-Seq_K562_Human0.84253180
104ETS1_22383799_ChIP-Seq_G1ME_Mouse0.84099503
105* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83279516
106SPI1_20517297_ChIP-Seq_HL60_Human0.82801980
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81223652
108AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79977008
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78958475
110MYC_22102868_ChIP-Seq_BL_Human0.78129522
111ZNF263_19887448_ChIP-Seq_K562_Human0.77764102
112ESR2_21235772_ChIP-Seq_MCF-7_Human0.76955913
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76619260
114NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.76260034
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75727176
116* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75102805
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74929433
118KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74700831
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.72492685
120NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72115411
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72115411
122SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71685650
123IKZF1_21737484_ChIP-ChIP_HCT116_Human0.71617406
124KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.70490844
125SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.70429622
126AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70254372
127RARA_24833708_ChIP-Seq_LIVER_Mouse0.67804701
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.67325042
129ELK3_25401928_ChIP-Seq_HUVEC_Human0.67085870
130RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66281608
131RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65306712
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63761796
133* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.63545159
134NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.62381923
135BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61521260
136CEBPB_22108803_ChIP-Seq_LS180_Human0.61398429
137ESR1_21235772_ChIP-Seq_MCF-7_Human0.59426704
138RARB_24833708_ChIP-Seq_LIVER_Mouse0.59233492
139FOXO3_23340844_ChIP-Seq_DLD1_Human0.58023150
140LXR_22292898_ChIP-Seq_THP-1_Human0.57563308
141PPAR_26484153_Chip-Seq_NCI-H1993_Human0.56329683
142FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53719866
143MYC_19915707_ChIP-ChIP_AK7_Human0.53567725
144STAT3_1855785_ChIP-Seq_MESCs_Mouse0.53283365
145FOXA1_25552417_ChIP-Seq_VCAP_Human0.53177875
146PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52877366
147EGR1_19032775_ChIP-ChIP_M12_Human0.52693303
148ESR1_20079471_ChIP-ChIP_T-47D_Human0.52025007
149ESET_19884257_ChIP-Seq_ESCs_Mouse0.51852711
150AR_20517297_ChIP-Seq_VCAP_Human0.50885125
151PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.50348536
152CBP_21632823_ChIP-Seq_H3396_Human0.50328631
153ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.49922251
154STAT1_17558387_ChIP-Seq_HELA_Human0.49423661
155BCAT_22108803_ChIP-Seq_LS180_Human0.48238727
156FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.47038657
157GATA1_19941826_ChIP-Seq_K562_Human0.46986049
158PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.45872956
159* CDX2_20551321_ChIP-Seq_CACO-2_Human0.44980830
160P53_21459846_ChIP-Seq_SAOS-2_Human0.44390610
161GATA2_19941826_ChIP-Seq_K562_Human0.44325260
162ERG_21242973_ChIP-ChIP_JURKAT_Human0.43210040
163PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42834745
164* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41889073
165SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41313099
166GATA6_25053715_ChIP-Seq_YYC3_Human0.40743803
167EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.40418847
168TAF2_19829295_ChIP-Seq_ESCs_Human0.40372908
169TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.39979399
170SOX2_20726797_ChIP-Seq_SW620_Human0.39802250
171GATA1_19941827_ChIP-Seq_MEL_Mouse0.39757855
172GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.39656742
173GATA3_24758297_ChIP-Seq_MCF-7_Human0.38586877
174GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.38317066
175CDX2_22108803_ChIP-Seq_LS180_Human0.37546093
176SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.36941071
177STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36705749
178CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.36252478
179ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.35566297
180CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.35499769
181NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.35297138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.26509132
2MP0005360_urolithiasis7.61882926
3MP0005085_abnormal_gallbladder_physiolo6.14696868
4MP0005365_abnormal_bile_salt6.07314283
5MP0008875_abnormal_xenobiotic_pharmacok4.85490902
6MP0003806_abnormal_nucleotide_metabolis4.09775235
7MP0003252_abnormal_bile_duct3.82888876
8MP0010329_abnormal_lipoprotein_level3.66662355
9MP0003303_peritoneal_inflammation3.29901635
10MP0003172_abnormal_lysosome_physiology3.21219692
11MP0001835_abnormal_antigen_presentation2.99492911
12MP0009840_abnormal_foam_cell2.93559500
13MP0005332_abnormal_amino_acid2.87852486
14MP0002419_abnormal_innate_immunity2.87812440
15MP0002148_abnormal_hypersensitivity_rea2.82427192
16MP0005083_abnormal_biliary_tract2.78110648
17MP0003195_calcinosis2.74444767
18* MP0005671_abnormal_response_to2.57605601
19MP0002877_abnormal_melanocyte_morpholog2.55140695
20MP0001666_abnormal_nutrient_absorption2.50893689
21MP0000343_altered_response_to2.49848084
22MP0003300_gastrointestinal_ulcer2.29926718
23MP0005025_abnormal_response_to2.29239667
24MP0004019_abnormal_vitamin_homeostasis2.26868475
25MP0003191_abnormal_cellular_cholesterol2.26138094
26MP0002118_abnormal_lipid_homeostasis2.21726949
27MP0005000_abnormal_immune_tolerance2.19808278
28MP0000609_abnormal_liver_physiology2.16217406
29MP0005397_hematopoietic_system_phenotyp2.14998034
30MP0001545_abnormal_hematopoietic_system2.14998034
31* MP0002452_abnormal_antigen_presenting2.11856347
32MP0000569_abnormal_digit_pigmentation2.09355347
33MP0005387_immune_system_phenotype2.08794410
34MP0001790_abnormal_immune_system2.08794410
35MP0009785_altered_susceptibility_to2.08309698
36MP0009278_abnormal_bone_marrow2.05451005
37MP0008004_abnormal_stomach_pH1.96881639
38MP0002138_abnormal_hepatobiliary_system1.93965768
39* MP0002723_abnormal_immune_serum1.88437859
40MP0000685_abnormal_immune_system1.86449544
41MP0004947_skin_inflammation1.83694578
42MP0001800_abnormal_humoral_immune1.81743143
43MP0002998_abnormal_bone_remodeling1.80442885
44* MP0001819_abnormal_immune_cell1.80000783
45* MP0002420_abnormal_adaptive_immunity1.79784396
46MP0003868_abnormal_feces_composition1.79276081
47* MP0005319_abnormal_enzyme/_coenzyme1.78053924
48MP0001533_abnormal_skeleton_physiology1.77236668
49MP0001764_abnormal_homeostasis1.73616054
50MP0001845_abnormal_inflammatory_respons1.64550882
51MP0005584_abnormal_enzyme/coenzyme_acti1.62328719
52MP0000015_abnormal_ear_pigmentation1.60910354
53MP0002405_respiratory_system_inflammati1.56984182
54MP0005670_abnormal_white_adipose1.52471591
55MP0003828_pulmonary_edema1.46679411
56MP0003186_abnormal_redox_activity1.46528010
57MP0009697_abnormal_copulation1.44391061
58MP0009643_abnormal_urine_homeostasis1.43968874
59* MP0000716_abnormal_immune_system1.37677389
60MP0005167_abnormal_blood-brain_barrier1.36090782
61MP0000465_gastrointestinal_hemorrhage1.35144625
62MP0003448_altered_tumor_morphology1.34742556
63* MP0002398_abnormal_bone_marrow1.32648313
64MP0005451_abnormal_body_composition1.31568129
65MP0003183_abnormal_peptide_metabolism1.25134753
66MP0003705_abnormal_hypodermis_morpholog1.24980723
67MP0010155_abnormal_intestine_physiology1.24173674
68MP0002876_abnormal_thyroid_physiology1.22380449
69MP0000858_altered_metastatic_potential1.21352600
70MP0004808_abnormal_hematopoietic_stem1.20433067
71MP0003011_delayed_dark_adaptation1.20282941
72MP0008260_abnormal_autophagy1.18960947
73MP0000689_abnormal_spleen_morphology1.18562344
74* MP0002429_abnormal_blood_cell1.16886089
75MP0003091_abnormal_cell_migration1.16666174
76MP0002396_abnormal_hematopoietic_system1.16283058
77MP0004130_abnormal_muscle_cell1.15320418
78MP0000598_abnormal_liver_morphology1.13824668
79MP0005647_abnormal_sex_gland1.13686232
80MP0001851_eye_inflammation1.10815850
81MP0002722_abnormal_immune_system1.08937789
82MP0009333_abnormal_splenocyte_physiolog1.08366369
83MP0005174_abnormal_tail_pigmentation1.06171599
84MP0003656_abnormal_erythrocyte_physiolo1.05126486
85MP0009764_decreased_sensitivity_to1.02527767
86MP0005636_abnormal_mineral_homeostasis0.99721989
87MP0005666_abnormal_adipose_tissue0.98022227
88MP0009763_increased_sensitivity_to0.98012548
89MP0000604_amyloidosis0.97586631
90MP0000371_diluted_coat_color0.97561826
91MP0002254_reproductive_system_inflammat0.96797017
92MP0002971_abnormal_brown_adipose0.96305235
93MP0004510_myositis0.95864493
94MP0005334_abnormal_fat_pad0.93703848
95MP0001958_emphysema0.92897094
96MP0005310_abnormal_salivary_gland0.92690630
97MP0006036_abnormal_mitochondrial_physio0.92053796
98MP0000920_abnormal_myelination0.91314596
99MP0005535_abnormal_body_temperature0.88175794
100MP0003795_abnormal_bone_structure0.87615269
101MP0002078_abnormal_glucose_homeostasis0.86445132
102MP0003279_aneurysm0.86314342
103MP0004883_abnormal_blood_vessel0.85625804
104* MP0009642_abnormal_blood_homeostasis0.85613001
105MP0001661_extended_life_span0.85178237
106MP0003566_abnormal_cell_adhesion0.82147956
107MP0003690_abnormal_glial_cell0.82141818
108* MP0008469_abnormal_protein_level0.81996625
109MP0005084_abnormal_gallbladder_morpholo0.81062910
110MP0010368_abnormal_lymphatic_system0.80649060
111MP0005390_skeleton_phenotype0.80505607
112MP0001756_abnormal_urination0.78818058
113MP0005376_homeostasis/metabolism_phenot0.77867453
114MP0005408_hypopigmentation0.75009518
115MP0002837_dystrophic_cardiac_calcinosis0.73931732
116MP0009765_abnormal_xenobiotic_induced0.73924703
117MP0010386_abnormal_urinary_bladder0.72411613
118MP0010307_abnormal_tumor_latency0.70894691
119MP0003453_abnormal_keratinocyte_physiol0.67322544
120MP0005448_abnormal_energy_balance0.67017161
121MP0005220_abnormal_exocrine_pancreas0.65640207
122MP0005165_increased_susceptibility_to0.64665174
123MP0005266_abnormal_metabolism0.64513562
124MP0008438_abnormal_cutaneous_collagen0.64378233
125MP0005023_abnormal_wound_healing0.61428477
126MP0009115_abnormal_fat_cell0.60805167
127MP0003329_amyloid_beta_deposits0.60678684
128MP0002166_altered_tumor_susceptibility0.60013708
129* MP0002136_abnormal_kidney_physiology0.56959847
130MP0003724_increased_susceptibility_to0.56462181
131MP0006035_abnormal_mitochondrial_morpho0.52010995
132MP0009053_abnormal_anal_canal0.51512601
133MP0004185_abnormal_adipocyte_glucose0.51323600
134MP0002970_abnormal_white_adipose0.50020871
135MP0005375_adipose_tissue_phenotype0.49804814
136MP0000639_abnormal_adrenal_gland0.49333780
137MP0003953_abnormal_hormone_level0.48275850
138MP0002928_abnormal_bile_duct0.46300531
139MP0002796_impaired_skin_barrier0.45874541
140MP0004043_abnormal_pH_regulation0.45421326
141MP0005395_other_phenotype0.45324320
142MP0003638_abnormal_response/metabolism_0.44665094
143MP0003959_abnormal_lean_body0.43049086
144MP0008874_decreased_physiological_sensi0.42207663
145MP0002168_other_aberrant_phenotype0.41532658
146MP0009672_abnormal_birth_weight0.41499453
147MP0004782_abnormal_surfactant_physiolog0.41236963
148MP0000230_abnormal_systemic_arterial0.41226451
149MP0003075_altered_response_to0.40918890
150MP0005058_abnormal_lysosome_morphology0.38311260
151MP0005464_abnormal_platelet_physiology0.37976433
152MP0008873_increased_physiological_sensi0.37906901
153MP0001881_abnormal_mammary_gland0.37046273
154MP0008872_abnormal_physiological_respon0.34637685
155MP0002822_catalepsy0.33888484
156MP0003436_decreased_susceptibility_to0.33867101
157MP0005166_decreased_susceptibility_to0.32723534
158MP0004381_abnormal_hair_follicle0.32593892
159MP0000249_abnormal_blood_vessel0.32396622
160MP0001765_abnormal_ion_homeostasis0.32027251
161MP0005248_abnormal_Harderian_gland0.31657525
162MP0001853_heart_inflammation0.31622132
163MP0003718_maternal_effect0.29172252
164MP0002060_abnormal_skin_morphology0.28410861
165MP0005164_abnormal_response_to0.27515546
166MP0005452_abnormal_adipose_tissue0.27512583
167MP0006082_CNS_inflammation0.26716095

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.08725721
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.00378545
3Vacuolated lymphocytes (HP:0001922)6.92645390
4Deep venous thrombosis (HP:0002625)6.89115301
5Abnormality of liposaccharide metabolism (HP:0010968)6.22195809
6Abnormality of glycosphingolipid metabolism (HP:0004343)6.22195809
7Abnormality of glycolipid metabolism (HP:0010969)6.22195809
8Abnormality of monocarboxylic acid metabolism (HP:0010996)6.20491889
9Xanthomatosis (HP:0000991)6.15370524
10Prolonged partial thromboplastin time (HP:0003645)5.96537542
11Hypobetalipoproteinemia (HP:0003563)5.91600463
12Hyperlipoproteinemia (HP:0010980)5.28535220
13Complement deficiency (HP:0004431)5.25899288
14Recurrent bacterial skin infections (HP:0005406)5.09724752
15Abnormality of macrophages (HP:0004311)5.03359328
16Recurrent abscess formation (HP:0002722)4.94658028
17Dysostosis multiplex (HP:0000943)4.73569424
18Hyperglycinemia (HP:0002154)4.71456397
19Hyperammonemia (HP:0001987)4.66327353
20Hyperglycinuria (HP:0003108)4.56555808
21Ketosis (HP:0001946)4.51800706
22Hypolipoproteinemia (HP:0010981)4.50752360
23Epidermoid cyst (HP:0200040)4.46958589
24Abnormality of glycine metabolism (HP:0010895)4.41203375
25Abnormality of serine family amino acid metabolism (HP:0010894)4.41203375
26Joint hemorrhage (HP:0005261)4.39250217
27Abnormality of glutamine family amino acid metabolism (HP:0010902)4.33384326
28Spontaneous hematomas (HP:0007420)4.23073327
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.19367575
30Abnormality of sulfur amino acid metabolism (HP:0004339)4.10444581
31Abnormality of aspartate family amino acid metabolism (HP:0010899)4.04372354
32Fat malabsorption (HP:0002630)4.01451375
33Hypoalphalipoproteinemia (HP:0003233)3.99701088
34Abnormality of the common coagulation pathway (HP:0010990)3.97911265
35Increased cerebral lipofuscin (HP:0011813)3.97060465
36Hypoglycemic coma (HP:0001325)3.95712728
37Abnormality of methionine metabolism (HP:0010901)3.89592997
38Abnormality of complement system (HP:0005339)3.81098435
39Eczematoid dermatitis (HP:0000976)3.72713820
40Abnormality of fatty-acid metabolism (HP:0004359)3.62233463
41Purpura (HP:0000979)3.61602008
42Petechiae (HP:0000967)3.61258616
43Hypercholesterolemia (HP:0003124)3.54029480
44Conjugated hyperbilirubinemia (HP:0002908)3.51125110
45Abnormality of pyrimidine metabolism (HP:0004353)3.50226650
46Prolonged bleeding time (HP:0003010)3.50136475
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.49195533
48Abnormality of the intrinsic pathway (HP:0010989)3.48903497
49Increased neuronal autofluorescent lipopigment (HP:0002074)3.46603178
50Ketoacidosis (HP:0001993)3.43505954
51Epistaxis (HP:0000421)3.33768013
52Delayed CNS myelination (HP:0002188)3.23701832
53Hyperbilirubinemia (HP:0002904)3.22273711
54Abnormality of nucleobase metabolism (HP:0010932)3.19956909
55Loss of speech (HP:0002371)3.19725188
56Abnormality of serum amino acid levels (HP:0003112)3.16808259
57Recurrent skin infections (HP:0001581)3.11148697
58Abnormal platelet volume (HP:0011876)3.09786155
59Urinary glycosaminoglycan excretion (HP:0003541)3.08961467
60Mucopolysacchariduria (HP:0008155)3.08961467
61Disinhibition (HP:0000734)3.08545329
62Increased mean platelet volume (HP:0011877)3.06999719
63Abnormality of mucopolysaccharide metabolism (HP:0011020)3.06003084
64Abnormality of polysaccharide metabolism (HP:0011012)3.06003084
65Abnormality of glycosaminoglycan metabolism (HP:0004371)3.06003084
66Abnormality of purine metabolism (HP:0004352)3.04822039
67Steatorrhea (HP:0002570)3.04702975
68Hepatosplenomegaly (HP:0001433)3.01146737
69Myocardial infarction (HP:0001658)2.98930296
70Axonal loss (HP:0003447)2.91469470
71Hepatocellular carcinoma (HP:0001402)2.91271828
72Metabolic acidosis (HP:0001942)2.86164043
73Gingival bleeding (HP:0000225)2.84430072
74Gout (HP:0001997)2.83841516
75Dicarboxylic aciduria (HP:0003215)2.82558496
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.82558496
77Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.82228832
78Skin nodule (HP:0200036)2.77453552
79Upper motor neuron abnormality (HP:0002127)2.75723701
80Agnosia (HP:0010524)2.73070598
81Systemic lupus erythematosus (HP:0002725)2.71929754
82Lethargy (HP:0001254)2.71407699
83Chronic obstructive pulmonary disease (HP:0006510)2.71046385
84Obstructive lung disease (HP:0006536)2.71046385
85Abnormality of the vasculature of the conjunctiva (HP:0008054)2.65616246
86Osteolytic defects of the hand bones (HP:0009699)2.65362050
87Osteolytic defects of the phalanges of the hand (HP:0009771)2.65362050
88Vascular calcification (HP:0004934)2.63448504
89Hypochromic microcytic anemia (HP:0004840)2.60802498
90Tetraparesis (HP:0002273)2.60719908
91Spondylolisthesis (HP:0003302)2.56165040
92Gingivitis (HP:0000230)2.55710513
93Spastic diplegia (HP:0001264)2.50122414
94Generalized aminoaciduria (HP:0002909)2.45539529
95Autoimmune thrombocytopenia (HP:0001973)2.44207864
96Hypoglycemic seizures (HP:0002173)2.43740587
97Abnormal platelet function (HP:0011869)2.43055191
98Impaired platelet aggregation (HP:0003540)2.43055191
99Cerebral edema (HP:0002181)2.42472533
100Mediastinal lymphadenopathy (HP:0100721)2.40857221
101Recurrent fungal infections (HP:0002841)2.39670602
102Spontaneous abortion (HP:0005268)2.38810373
103Abnormal gallbladder morphology (HP:0012437)2.38265042
104Neonatal onset (HP:0003623)2.36640031
105Cardiovascular calcification (HP:0011915)2.36511435
106Abnormality of the prostate (HP:0008775)2.35503670
107Irritability (HP:0000737)2.35021069
108Acanthocytosis (HP:0001927)2.34549608
109Malnutrition (HP:0004395)2.32432835
110Mitral stenosis (HP:0001718)2.31656156
111Cholelithiasis (HP:0001081)2.31208361
112Pancreatitis (HP:0001733)2.30719616
113Mutism (HP:0002300)2.29433726
114Sensorimotor neuropathy (HP:0007141)2.27314975
115Pustule (HP:0200039)2.25759513
116Asymmetric septal hypertrophy (HP:0001670)2.24495846
117Chronic mucocutaneous candidiasis (HP:0002728)2.24077775
118Recurrent cutaneous fungal infections (HP:0011370)2.24077775
119Conjunctival telangiectasia (HP:0000524)2.23871685
120Premature loss of primary teeth (HP:0006323)2.23633294
121Hydroxyprolinuria (HP:0003080)2.23145774
122Abnormality of proline metabolism (HP:0010907)2.23145774
123Vomiting (HP:0002013)2.22140789
124Cholecystitis (HP:0001082)2.21948972
125Abnormal gallbladder physiology (HP:0012438)2.21948972
126Bone pain (HP:0002653)2.21848862
127Recurrent gram-negative bacterial infections (HP:0005420)2.20409200
128Late onset (HP:0003584)2.19305733
129Protuberant abdomen (HP:0001538)2.18416602
130Meningitis (HP:0001287)2.16990106
131Recurrent viral infections (HP:0004429)2.15653927
132Hemorrhage of the eye (HP:0011885)2.15424955
133Pathologic fracture (HP:0002756)2.15354464
134Glomerulonephritis (HP:0000099)2.14848898
135Brushfield spots (HP:0001088)2.14678982
136Enlarged kidneys (HP:0000105)2.14067993
137Interstitial pulmonary disease (HP:0006530)2.13273654
138Periodontitis (HP:0000704)2.12683824
139Proximal tubulopathy (HP:0000114)2.12594182
140Stomatitis (HP:0010280)2.11469844
141Thick nail (HP:0001805)2.10738449
142Esophageal varix (HP:0002040)2.10626722
143Amaurosis fugax (HP:0100576)2.09465840
144T lymphocytopenia (HP:0005403)2.08233969
145Hyperuricemia (HP:0002149)2.06570549
146Increased purine levels (HP:0004368)2.06570549
147Abnormal cartilage morphology (HP:0002763)2.06312985
148Amyloidosis (HP:0011034)2.06040938
149Rickets (HP:0002748)2.03812864
150Alkalosis (HP:0001948)2.03734393
151Hypertriglyceridemia (HP:0002155)2.03222981
152Cellulitis (HP:0100658)2.03073835
153Myositis (HP:0100614)2.02497547
154Increased serum ferritin (HP:0003281)2.02482255
155Opisthotonus (HP:0002179)2.01119891
156Basal ganglia calcification (HP:0002135)1.99742681
157Hematochezia (HP:0002573)1.98757863
158Diminished motivation (HP:0000745)1.97102630
159Abnormality of the gallbladder (HP:0005264)1.96140894
160Progressive neurologic deterioration (HP:0002344)1.96047173
161Metaphyseal irregularity (HP:0003025)1.95711182
162Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.95378562
163Hyperinsulinemic hypoglycemia (HP:0000825)1.95282631
164Abnormal enzyme/coenzyme activity (HP:0012379)1.93999205
165Osteomyelitis (HP:0002754)1.93716067
166Apathy (HP:0000741)1.91788915
167Neurofibrillary tangles (HP:0002185)1.91704709
168Menorrhagia (HP:0000132)1.90604676
169Renal cortical cysts (HP:0000803)1.90592050
170Abnormality of urine glucose concentration (HP:0011016)1.89998969
171Glycosuria (HP:0003076)1.89998969
172Abnormality of iron homeostasis (HP:0011031)1.89207728
173Thin bony cortex (HP:0002753)1.88999520
174Thrombocytosis (HP:0001894)1.87832151
175Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.87652390
176Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.85489877
177Thoracic kyphosis (HP:0002942)1.84842122
178Vertebral compression fractures (HP:0002953)1.84519502
179Orchitis (HP:0100796)1.83667701
180Elevated hepatic transaminases (HP:0002910)1.82787194
181Thrombophlebitis (HP:0004418)1.82172685
182Hypophosphatemic rickets (HP:0004912)1.80277720
183Nausea (HP:0002018)1.79956909
184Abnormality of T cell number (HP:0011839)1.79436659
185Albinism (HP:0001022)1.79121418
186Abnormality of vitamin metabolism (HP:0100508)1.78096865
187Retrobulbar optic neuritis (HP:0100654)1.77942450
188Optic neuritis (HP:0100653)1.77942450
189Distal lower limb amyotrophy (HP:0008944)1.77836570

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.23332875
2SIK14.94432486
3FGFR44.06091200
4RIPK44.02379892
5ERN13.98166793
6BLK3.70188554
7INSRR2.84481570
8TAOK32.65693885
9TRIB32.46158520
10SCYL22.44054593
11MST1R2.43471818
12TTN2.41496525
13ZAP702.38763390
14ERBB42.38012393
15TEC2.21898711
16PKN22.14839119
17MAP2K42.02542300
18GRK71.90971263
19KIT1.90546849
20PIK3CG1.87935645
21SYK1.87728773
22BTK1.87080107
23PRPF4B1.80584774
24CAMK1D1.79179248
25FLT31.78292439
26TRPM71.74761587
27CAMKK21.74326134
28MAPK111.72885147
29FRK1.71299154
30FES1.61571070
31LATS11.61515019
32MATK1.59390051
33BMPR21.52893176
34FGFR21.52020453
35JAK31.49252849
36TYK21.42243753
37DAPK21.41736448
38ABL21.38852423
39PRKAA21.37528799
40FGR1.33960116
41NEK91.32608225
42PTK61.31898936
43LYN1.28050277
44HCK1.25649996
45MAP4K11.19690945
46JAK21.17652529
47MAP3K71.16826083
48IRAK41.16761556
49PINK11.16748367
50KDR1.11063440
51CAMK1G1.10503929
52MOS1.07712407
53TESK21.04251216
54MAP2K31.03159931
55IKBKB1.03088790
56STK38L1.02237437
57EEF2K1.01551732
58ITK1.01417717
59JAK10.98907633
60RIPK10.96653016
61PDK30.95468107
62PDK40.95468107
63MET0.94788093
64TIE10.91552501
65CDK60.91247387
66ACVR1B0.90316313
67TXK0.90156202
68GRK60.89825182
69LCK0.87712646
70TBK10.87169018
71PRKCZ0.86168022
72MAP3K100.86112986
73NME20.84614947
74MAPK40.83334029
75ADRBK20.82841569
76MAP3K140.82093931
77PRKAA10.79754897
78MAP3K30.78975558
79PIM20.78793099
80DDR20.78587978
81PRKACG0.77938809
82IRAK30.77690445
83RPS6KA20.76940847
84GSK3A0.76665916
85ERBB20.76431032
86MAPKAPK30.76053925
87MAP3K10.74656882
88CSK0.73222761
89MAPK120.72948224
90FGFR30.72529351
91BMX0.71581778
92WNK40.70241158
93MAP3K20.69998808
94TGFBR20.67217870
95MAPK150.66946208
96EPHB10.66896747
97SGK30.66708423
98CDC42BPA0.65084993
99MARK30.63721616
100DYRK1B0.63333976
101PDPK10.62963009
102MAP3K110.54907702
103CAMK2G0.54382489
104MAP2K10.54318285
105PTK20.53549327
106CSF1R0.52667059
107WNK30.52010211
108IGF1R0.51477836
109MAP3K60.50905243
110MAP2K60.50373614
111STK240.48749515
112SGK2230.48697252
113SGK4940.48697252
114RPS6KL10.47990547
115RPS6KC10.47990547
116TNK20.47466263
117CSNK1G10.46139079
118SGK20.45810851
119ABL10.45351856
120YES10.45177922
121PIK3CA0.44358374
122RET0.44091524
123PDK10.43498377
124PRKCQ0.42615009
125PIM10.41774826
126STK100.40502464
127KSR20.40278507
128PDK20.40156653
129CAMKK10.39915198
130EPHA30.39523479
131MTOR0.39522120
132PDGFRB0.39017161
133CDK40.38607924
134MAPK70.38189160
135OXSR10.37258330
136ARAF0.36815447
137FYN0.35026482
138EIF2AK30.34952309
139IKBKE0.34624028
140ICK0.34140838
141RPS6KA60.33974433
142IRAK10.33794922
143IRAK20.32589833
144GRK10.32388413
145PAK10.31898327
146PDGFRA0.31284097
147MAP3K50.29007737
148MAP3K130.28803975
149LATS20.27155174
150TAOK20.27026235
151EGFR0.26128322
152EPHA40.25698040
153EPHB20.25045034
154PRKCG0.24464180
155PKN10.23697273
156PRKCH0.23520584
157FGFR10.23025485
158PRKCA0.22822809

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.35579037
2Other glycan degradation_Homo sapiens_hsa005114.00272322
3Lysosome_Homo sapiens_hsa041423.64336053
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.36105818
5Nitrogen metabolism_Homo sapiens_hsa009103.33161217
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.05336870
7Arginine biosynthesis_Homo sapiens_hsa002202.85557979
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.73722659
9Tryptophan metabolism_Homo sapiens_hsa003802.68968736
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68310422
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.63367664
12Fatty acid degradation_Homo sapiens_hsa000712.60379046
13Leishmaniasis_Homo sapiens_hsa051402.51459735
14Osteoclast differentiation_Homo sapiens_hsa043802.50794140
15Complement and coagulation cascades_Homo sapiens_hsa046102.49516143
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48249607
17Asthma_Homo sapiens_hsa053102.44977138
18Butanoate metabolism_Homo sapiens_hsa006502.32948058
19Pentose and glucuronate interconversions_Homo sapiens_hsa000402.31067318
20Propanoate metabolism_Homo sapiens_hsa006402.26926182
21Hematopoietic cell lineage_Homo sapiens_hsa046402.24127695
22Peroxisome_Homo sapiens_hsa041462.18427806
23Phagosome_Homo sapiens_hsa041452.16190249
24Tuberculosis_Homo sapiens_hsa051522.13698342
25Rheumatoid arthritis_Homo sapiens_hsa053232.12175944
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10779306
27PPAR signaling pathway_Homo sapiens_hsa033202.08188256
28Toll-like receptor signaling pathway_Homo sapiens_hsa046202.02116909
29Fatty acid metabolism_Homo sapiens_hsa012121.98507427
30Chemical carcinogenesis_Homo sapiens_hsa052041.88233828
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87276089
32Histidine metabolism_Homo sapiens_hsa003401.84145367
33beta-Alanine metabolism_Homo sapiens_hsa004101.83420174
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.82850469
35Platelet activation_Homo sapiens_hsa046111.81311158
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71641306
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.69890355
38B cell receptor signaling pathway_Homo sapiens_hsa046621.68731364
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68153875
40Allograft rejection_Homo sapiens_hsa053301.67177102
41Retinol metabolism_Homo sapiens_hsa008301.65141388
42Caffeine metabolism_Homo sapiens_hsa002321.64961604
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63494784
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62744956
45Staphylococcus aureus infection_Homo sapiens_hsa051501.60543515
46Phenylalanine metabolism_Homo sapiens_hsa003601.56852246
47Pyruvate metabolism_Homo sapiens_hsa006201.56495589
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.55475022
49Malaria_Homo sapiens_hsa051441.54307480
50Chemokine signaling pathway_Homo sapiens_hsa040621.53439302
51Selenocompound metabolism_Homo sapiens_hsa004501.50940595
52Bile secretion_Homo sapiens_hsa049761.48317968
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.47589889
54NF-kappa B signaling pathway_Homo sapiens_hsa040641.45868997
55Tyrosine metabolism_Homo sapiens_hsa003501.44675423
56Sulfur metabolism_Homo sapiens_hsa009201.40963497
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.40664362
58Pertussis_Homo sapiens_hsa051331.38348175
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37400216
60Collecting duct acid secretion_Homo sapiens_hsa049661.36876319
61Fatty acid elongation_Homo sapiens_hsa000621.35956276
62Graft-versus-host disease_Homo sapiens_hsa053321.35032130
63Autoimmune thyroid disease_Homo sapiens_hsa053201.34312574
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33041958
65Starch and sucrose metabolism_Homo sapiens_hsa005001.31653724
66NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29311059
67Legionellosis_Homo sapiens_hsa051341.28411440
68Toxoplasmosis_Homo sapiens_hsa051451.24532858
69Carbon metabolism_Homo sapiens_hsa012001.22951870
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22923128
71Fat digestion and absorption_Homo sapiens_hsa049751.21571272
72Cysteine and methionine metabolism_Homo sapiens_hsa002701.18777058
73ABC transporters_Homo sapiens_hsa020101.17355952
74Biosynthesis of amino acids_Homo sapiens_hsa012301.14427760
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13949002
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13581079
77Folate biosynthesis_Homo sapiens_hsa007901.12771213
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11056487
79Cyanoamino acid metabolism_Homo sapiens_hsa004601.09704402
80Steroid biosynthesis_Homo sapiens_hsa001001.09279941
81Acute myeloid leukemia_Homo sapiens_hsa052211.05471668
82Influenza A_Homo sapiens_hsa051641.05145711
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03883863
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02027386
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01918395
86Type I diabetes mellitus_Homo sapiens_hsa049401.00906476
87Antigen processing and presentation_Homo sapiens_hsa046121.00002295
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99754803
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99504822
90Vitamin B6 metabolism_Homo sapiens_hsa007500.99199808
91Salmonella infection_Homo sapiens_hsa051320.99157404
92TNF signaling pathway_Homo sapiens_hsa046680.98329683
93Arginine and proline metabolism_Homo sapiens_hsa003300.93352496
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.90925838
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90357228
96Glycerolipid metabolism_Homo sapiens_hsa005610.89942711
97Measles_Homo sapiens_hsa051620.89839034
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.87501064
99Sulfur relay system_Homo sapiens_hsa041220.86877796
100Vitamin digestion and absorption_Homo sapiens_hsa049770.84769464
101Lysine degradation_Homo sapiens_hsa003100.83905904
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.83800768
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81563246
104Pancreatic cancer_Homo sapiens_hsa052120.80163359
105Apoptosis_Homo sapiens_hsa042100.79778497
106Fatty acid biosynthesis_Homo sapiens_hsa000610.79670403
107Shigellosis_Homo sapiens_hsa051310.79586280
108Viral myocarditis_Homo sapiens_hsa054160.79370979
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75964183
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75590316
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75081595
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74786345
113Sphingolipid metabolism_Homo sapiens_hsa006000.73946485
114Hepatitis B_Homo sapiens_hsa051610.72783430
115Glutathione metabolism_Homo sapiens_hsa004800.70998670
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.68993573
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67402038
118Non-small cell lung cancer_Homo sapiens_hsa052230.66986409
119Vibrio cholerae infection_Homo sapiens_hsa051100.63826960
120One carbon pool by folate_Homo sapiens_hsa006700.63578144
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63485700
122Primary immunodeficiency_Homo sapiens_hsa053400.61265136
123Pentose phosphate pathway_Homo sapiens_hsa000300.60797441
124Herpes simplex infection_Homo sapiens_hsa051680.60361567
125Chronic myeloid leukemia_Homo sapiens_hsa052200.59663466
126Renal cell carcinoma_Homo sapiens_hsa052110.59112957
127T cell receptor signaling pathway_Homo sapiens_hsa046600.58775745
128Prolactin signaling pathway_Homo sapiens_hsa049170.57940731
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57191816
130Endocytosis_Homo sapiens_hsa041440.54516335
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.49921288
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.49744184
133Viral carcinogenesis_Homo sapiens_hsa052030.48363512
134VEGF signaling pathway_Homo sapiens_hsa043700.46466526
135Metabolic pathways_Homo sapiens_hsa011000.46291323
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45158580
137HIF-1 signaling pathway_Homo sapiens_hsa040660.42767382
138Bladder cancer_Homo sapiens_hsa052190.41888136
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40394467
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37023043
141Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36353944
142GnRH signaling pathway_Homo sapiens_hsa049120.33864479
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.33562793
144alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32713534
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31327115
146Prion diseases_Homo sapiens_hsa050200.31065696
147Insulin resistance_Homo sapiens_hsa049310.28474129
148Fructose and mannose metabolism_Homo sapiens_hsa000510.27846074
149Dorso-ventral axis formation_Homo sapiens_hsa043200.27429082
150Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26924690
151Galactose metabolism_Homo sapiens_hsa000520.25164966
152Linoleic acid metabolism_Homo sapiens_hsa005910.23504843
153Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18704354
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.18134238
155AMPK signaling pathway_Homo sapiens_hsa041520.14153784
156Glucagon signaling pathway_Homo sapiens_hsa049220.13347762
157Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.02178279
158Type II diabetes mellitus_Homo sapiens_hsa04930-0.2209242
159Amoebiasis_Homo sapiens_hsa05146-0.2208976
160Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2171935
161Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2052115
162African trypanosomiasis_Homo sapiens_hsa05143-0.1957932
163Hepatitis C_Homo sapiens_hsa05160-0.1809585
164Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1789626
165Protein digestion and absorption_Homo sapiens_hsa04974-0.1770740
166Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1708286
167Regulation of autophagy_Homo sapiens_hsa04140-0.1587654
168Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1488084
169Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1426980
170Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1283175
171Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1238754
172Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1219309
173Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1216682
174Renin-angiotensin system_Homo sapiens_hsa04614-0.1209185
175Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0910017
176Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0851712
177Insulin signaling pathway_Homo sapiens_hsa04910-0.0286595

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