SUCLG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.62245072
2L-phenylalanine catabolic process (GO:0006559)6.62245072
3L-phenylalanine metabolic process (GO:0006558)6.53575150
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.53575150
5aromatic amino acid family catabolic process (GO:0009074)5.99904958
6glyoxylate metabolic process (GO:0046487)5.82691028
7epoxygenase P450 pathway (GO:0019373)5.82547195
8lysine catabolic process (GO:0006554)5.57781677
9lysine metabolic process (GO:0006553)5.57781677
10NADH metabolic process (GO:0006734)5.52998297
11cysteine metabolic process (GO:0006534)5.47315569
12indole-containing compound catabolic process (GO:0042436)5.46470719
13indolalkylamine catabolic process (GO:0046218)5.46470719
14tryptophan catabolic process (GO:0006569)5.46470719
15kynurenine metabolic process (GO:0070189)5.38026232
16tryptophan metabolic process (GO:0006568)5.19548798
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.13367707
18bile acid biosynthetic process (GO:0006699)5.11603419
19alpha-linolenic acid metabolic process (GO:0036109)5.08801218
20sulfur amino acid catabolic process (GO:0000098)5.08346424
21serine family amino acid catabolic process (GO:0009071)5.04716008
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.96870062
23homocysteine metabolic process (GO:0050667)4.91905441
24amino-acid betaine metabolic process (GO:0006577)4.87540245
25urea cycle (GO:0000050)4.72880317
26urea metabolic process (GO:0019627)4.72880317
27glycine metabolic process (GO:0006544)4.70911366
28ethanol metabolic process (GO:0006067)4.66163922
29serine family amino acid metabolic process (GO:0009069)4.54752258
30serine family amino acid biosynthetic process (GO:0009070)4.48433771
31aromatic amino acid family metabolic process (GO:0009072)4.47254760
32negative regulation of fibrinolysis (GO:0051918)4.46719003
33alpha-amino acid catabolic process (GO:1901606)4.44246667
34nitrogen cycle metabolic process (GO:0071941)4.37721932
35bile acid metabolic process (GO:0008206)4.35400803
36cellular ketone body metabolic process (GO:0046950)4.32229004
37high-density lipoprotein particle remodeling (GO:0034375)4.30159672
38peptidyl-glutamic acid carboxylation (GO:0017187)4.28437546
39protein carboxylation (GO:0018214)4.28437546
40regulation of protein activation cascade (GO:2000257)4.24938545
41short-chain fatty acid metabolic process (GO:0046459)4.23635414
42ethanol oxidation (GO:0006069)4.23575416
43complement activation, alternative pathway (GO:0006957)4.18686327
44cellular amino acid catabolic process (GO:0009063)4.18221908
45regulation of fibrinolysis (GO:0051917)4.18177807
46regulation of triglyceride catabolic process (GO:0010896)4.16938779
47drug transmembrane transport (GO:0006855)4.16682975
48omega-hydroxylase P450 pathway (GO:0097267)4.15269696
49urate metabolic process (GO:0046415)4.15187258
50intestinal absorption (GO:0050892)4.14178229
51tyrosine metabolic process (GO:0006570)4.11967633
52fatty acid beta-oxidation (GO:0006635)4.09861840
532-oxoglutarate metabolic process (GO:0006103)4.09098015
54valine metabolic process (GO:0006573)4.05055396
55fructose metabolic process (GO:0006000)4.04149634
56aspartate family amino acid catabolic process (GO:0009068)4.03376907
57drug catabolic process (GO:0042737)4.01730001
58cellular modified amino acid catabolic process (GO:0042219)3.98925674
59regulation of complement activation (GO:0030449)3.97525322
60negative regulation of sterol transport (GO:0032372)3.96134709
61negative regulation of cholesterol transport (GO:0032375)3.96134709
62cellular glucuronidation (GO:0052695)3.95488416
63carnitine metabolic process (GO:0009437)3.93447143
64fatty acid oxidation (GO:0019395)3.92844393
65triglyceride homeostasis (GO:0070328)3.85840318
66acylglycerol homeostasis (GO:0055090)3.85840318
67lipid oxidation (GO:0034440)3.84567933
68acetyl-CoA metabolic process (GO:0006084)3.84109039
69benzene-containing compound metabolic process (GO:0042537)3.82977951
70branched-chain amino acid catabolic process (GO:0009083)3.82367419
71ketone body metabolic process (GO:1902224)3.81811717
72organic acid catabolic process (GO:0016054)3.81638546
73carboxylic acid catabolic process (GO:0046395)3.81638546
74regulation of cholesterol esterification (GO:0010872)3.80715935
75indolalkylamine metabolic process (GO:0006586)3.79127631
76very-low-density lipoprotein particle assembly (GO:0034379)3.78574569
77protein-lipid complex remodeling (GO:0034368)3.77281594
78macromolecular complex remodeling (GO:0034367)3.77281594
79plasma lipoprotein particle remodeling (GO:0034369)3.77281594
80fat-soluble vitamin biosynthetic process (GO:0042362)3.76757148
81hormone catabolic process (GO:0042447)3.75355708
82primary alcohol catabolic process (GO:0034310)3.75278101
83fatty acid catabolic process (GO:0009062)3.74557373
84glutamate metabolic process (GO:0006536)3.74170882
85bile acid and bile salt transport (GO:0015721)3.74082156
86amine catabolic process (GO:0009310)3.71400275
87cellular biogenic amine catabolic process (GO:0042402)3.71400275
88reverse cholesterol transport (GO:0043691)3.70608137
89imidazole-containing compound metabolic process (GO:0052803)3.70125949
90monocarboxylic acid catabolic process (GO:0072329)3.69886728
91coenzyme catabolic process (GO:0009109)3.66238237
92branched-chain amino acid metabolic process (GO:0009081)3.65674388
93fibrinolysis (GO:0042730)3.64729878
94drug transport (GO:0015893)3.57894883
95aldehyde catabolic process (GO:0046185)3.57597505
96regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.55629426
97phenylpropanoid metabolic process (GO:0009698)3.52698257
98plasma lipoprotein particle clearance (GO:0034381)3.51845651
99flavonoid metabolic process (GO:0009812)3.51068149
100phospholipid efflux (GO:0033700)3.50211788
101exogenous drug catabolic process (GO:0042738)3.48982940
102oxaloacetate metabolic process (GO:0006107)3.48961531
103glucuronate metabolic process (GO:0019585)3.48839629
104uronic acid metabolic process (GO:0006063)3.48839629
105polyketide metabolic process (GO:0030638)3.44947502
106doxorubicin metabolic process (GO:0044598)3.44947502
107daunorubicin metabolic process (GO:0044597)3.44947502
108response to nitrosative stress (GO:0051409)3.44022571
109dicarboxylic acid biosynthetic process (GO:0043650)3.42180176
110angiotensin maturation (GO:0002003)3.42144788
111complement activation, classical pathway (GO:0006958)3.42105492
112tricarboxylic acid metabolic process (GO:0072350)3.41550151
113L-serine metabolic process (GO:0006563)3.41384193
114drug metabolic process (GO:0017144)3.39993193
115negative regulation of fatty acid biosynthetic process (GO:0045717)3.37409178
116regulation of cholesterol homeostasis (GO:2000188)3.36654618
117arginine metabolic process (GO:0006525)3.35520488
118heme transport (GO:0015886)3.30987129
119phospholipid homeostasis (GO:0055091)3.30108030
120glutamine family amino acid biosynthetic process (GO:0009084)3.21303288
121complement activation (GO:0006956)3.14953154
122response to mercury ion (GO:0046689)3.14298089
123aminoglycoside antibiotic metabolic process (GO:0030647)3.13572273
124regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.12322744
125regulation of bile acid biosynthetic process (GO:0070857)3.10437325
126negative regulation of hemostasis (GO:1900047)3.09483610
127negative regulation of blood coagulation (GO:0030195)3.09483610
128protein activation cascade (GO:0072376)3.08108062
129primary alcohol metabolic process (GO:0034308)3.06372991
130positive regulation of lipoprotein lipase activity (GO:0051006)3.04281872
131positive regulation of triglyceride lipase activity (GO:0061365)3.04281872
132nucleotide-sugar biosynthetic process (GO:0009226)3.04078133
133Golgi transport vesicle coating (GO:0048200)3.03759598
134COPI coating of Golgi vesicle (GO:0048205)3.03759598
135protein-lipid complex assembly (GO:0065005)3.03541062
136* tricarboxylic acid cycle (GO:0006099)3.01056994
137negative regulation of coagulation (GO:0050819)2.98708680
138plasma lipoprotein particle assembly (GO:0034377)2.96834624
139regulation of plasminogen activation (GO:0010755)2.95811983
140COPII vesicle coating (GO:0048208)2.93636432
141transcytosis (GO:0045056)2.92567955
142negative regulation of protein activation cascade (GO:2000258)2.92325393
143creatine metabolic process (GO:0006600)2.90428417
144blood coagulation, intrinsic pathway (GO:0007597)2.89406398
145regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.85122330
146negative regulation of wound healing (GO:0061045)2.83301346
147muscle filament sliding (GO:0030049)2.81843738
148actin-myosin filament sliding (GO:0033275)2.81843738
149gluconeogenesis (GO:0006094)2.79247641
150bundle of His cell to Purkinje myocyte communication (GO:0086069)2.79039000
151glycoside metabolic process (GO:0016137)2.77574891
152acute-phase response (GO:0006953)2.74716256
153carnitine shuttle (GO:0006853)2.71800497
154proline metabolic process (GO:0006560)2.71671489
155positive regulation of lipid catabolic process (GO:0050996)2.71546145

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.75781017
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.72220196
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.99547999
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.51482855
5* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.39645029
6* LXR_22158963_ChIP-Seq_LIVER_Mouse5.06440365
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.32924651
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.80731084
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.55701576
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.95674570
11* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.88806034
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.71619532
13CDX2_20551321_ChIP-Seq_CACO-2_Human2.63188074
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.42077911
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.35361902
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.32339496
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19275545
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.03457752
19CLOCK_20551151_ChIP-Seq_293T_Human1.92457426
20SOX2_20726797_ChIP-Seq_SW620_Human1.87005810
21E2F7_22180533_ChIP-Seq_HELA_Human1.83661402
22KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.83619704
23GATA1_22025678_ChIP-Seq_K562_Human1.75253031
24PPAR_26484153_Chip-Seq_NCI-H1993_Human1.71279292
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.71237974
26SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.68256413
27AR_21909140_ChIP-Seq_LNCAP_Human1.68140990
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.61843274
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.61683994
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.61326987
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.56207365
32KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.55054812
33STAT3_1855785_ChIP-Seq_MESCs_Mouse1.49638279
34ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.49338168
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47125906
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.42396637
37TBX20_22328084_ChIP-Seq_HEART_Mouse1.41095663
38TBX20_22080862_ChIP-Seq_HEART_Mouse1.41095663
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40896311
40TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37943487
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35594310
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32432890
43FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.31154191
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30133897
45AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.27921908
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27018223
47SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25560778
48SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25560778
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23161716
50ZNF263_19887448_ChIP-Seq_K562_Human1.22693974
51* HNF4A_19822575_ChIP-Seq_HepG2_Human1.20551091
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19813866
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19502280
54RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18532619
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17892651
56RACK7_27058665_Chip-Seq_MCF-7_Human1.14762385
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14618062
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12455188
59* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10285022
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09962110
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08289073
62SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08249735
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08187421
64NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07867255
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07345808
66GATA3_24758297_ChIP-Seq_MCF-7_Human1.06306083
67GATA4_25053715_ChIP-Seq_YYC3_Human1.06037358
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05085686
69NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04753046
70* FOXA2_19822575_ChIP-Seq_HepG2_Human1.04448460
71EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01183635
72TCF4_18268006_ChIP-ChIP_LS174T_Human1.00672257
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97720586
74MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97477606
75* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97460096
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96900555
77SRF_21415370_ChIP-Seq_HL-1_Mouse0.96330929
78EP300_21415370_ChIP-Seq_HL-1_Mouse0.95280187
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94781128
80P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93892503
81IRF8_22096565_ChIP-ChIP_GC-B_Human0.92487373
82* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91965185
83NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90357563
84SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89991052
85* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89235341
86FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.88118041
87SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87310978
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.86211030
89JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.85553018
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.83789975
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82626254
92CHD1_26751641_Chip-Seq_LNCaP_Human0.82323605
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81729787
94* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81670444
95GATA4_21415370_ChIP-Seq_HL-1_Mouse0.81647465
96NANOG_18692474_ChIP-Seq_MEFs_Mouse0.81465560
97STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.81229629
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81076401
99FOXA1_25552417_ChIP-Seq_VCAP_Human0.81040086
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80529901
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.79828390
102SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.79403494
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.79388964
104P300_27058665_Chip-Seq_ZR-75-30cells_Human0.79375094
105BP1_19119308_ChIP-ChIP_Hs578T_Human0.78594661
106* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78236147
107NFIB_24661679_ChIP-Seq_LUNG_Mouse0.77727113
108CJUN_26792858_Chip-Seq_BT549_Human0.77679867
109ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77624140
110GATA6_25053715_ChIP-Seq_YYC3_Human0.77277896
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.76334968
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76140568
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76100645
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75339128
115HTT_18923047_ChIP-ChIP_STHdh_Human0.74963616
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.72122962
117FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.72016022
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.71848096
119DCP1A_22483619_ChIP-Seq_HELA_Human0.70385089
120SOX2_18692474_ChIP-Seq_MEFs_Mouse0.70122231
121EST1_17652178_ChIP-ChIP_JURKAT_Human0.69973666
122RARA_24833708_ChIP-Seq_LIVER_Mouse0.69285076
123MYC_19079543_ChIP-ChIP_MESCs_Mouse0.69026629
124KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67128482
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.66777509
126BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.66364868
127NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.66112345
128TCF3_18692474_ChIP-Seq_MEFs_Mouse0.65551597
129XRN2_22483619_ChIP-Seq_HELA_Human0.65409175
130ETS1_20019798_ChIP-Seq_JURKAT_Human0.63535365
131GABP_17652178_ChIP-ChIP_JURKAT_Human0.62331016
132OCT4_18692474_ChIP-Seq_MEFs_Mouse0.62278721
133TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.61552319
134ERG_20887958_ChIP-Seq_HPC-7_Mouse0.61352859
135NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.61229295
136ATF3_27146783_Chip-Seq_COLON_Human0.60984884
137FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.60525755
138TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.60073449
139RARB_24833708_ChIP-Seq_LIVER_Mouse0.59470600
140FOXP3_21729870_ChIP-Seq_TREG_Human0.59468085
141SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.58624551
142CEBPB_22108803_ChIP-Seq_LS180_Human0.58491575
143AUTS2_25519132_ChIP-Seq_293T-REX_Human0.58341434
144RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.57742759
145KLF4_18555785_ChIP-Seq_MESCs_Mouse0.57289445
146AR_20517297_ChIP-Seq_VCAP_Human0.56515063
147GABP_19822575_ChIP-Seq_HepG2_Human0.56507587
148MYCN_18555785_ChIP-Seq_MESCs_Mouse0.56388467
149NANOG_18555785_ChIP-Seq_MESCs_Mouse0.55808130
150FOXM1_23109430_ChIP-Seq_U2OS_Human0.54948046
151GATA2_22383799_ChIP-Seq_G1ME_Mouse0.54781165
152PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.54434730

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.33493379
2MP0005360_urolithiasis6.90667852
3MP0005085_abnormal_gallbladder_physiolo5.65094586
4MP0005365_abnormal_bile_salt5.56325021
5MP0003806_abnormal_nucleotide_metabolis4.48365347
6MP0008875_abnormal_xenobiotic_pharmacok4.46959786
7MP0003252_abnormal_bile_duct3.55072844
8MP0010329_abnormal_lipoprotein_level2.98753457
9MP0005332_abnormal_amino_acid2.96845009
10MP0005083_abnormal_biliary_tract2.68533007
11MP0009840_abnormal_foam_cell2.67513998
12MP0003195_calcinosis2.59049284
13MP0001666_abnormal_nutrient_absorption2.47907055
14MP0004019_abnormal_vitamin_homeostasis2.24933458
15MP0002138_abnormal_hepatobiliary_system2.02145664
16MP0000609_abnormal_liver_physiology1.98121768
17MP0003191_abnormal_cellular_cholesterol1.89965931
18MP0005319_abnormal_enzyme/_coenzyme1.89677796
19MP0000751_myopathy1.85023646
20MP0002118_abnormal_lipid_homeostasis1.84191490
21MP0003186_abnormal_redox_activity1.78497912
22MP0009643_abnormal_urine_homeostasis1.75106957
23MP0001764_abnormal_homeostasis1.65500234
24MP0000749_muscle_degeneration1.64488936
25MP0003868_abnormal_feces_composition1.57795207
26MP0004272_abnormal_basement_membrane1.54942650
27MP0005584_abnormal_enzyme/coenzyme_acti1.53061695
28MP0008438_abnormal_cutaneous_collagen1.45176976
29MP0006036_abnormal_mitochondrial_physio1.43512264
30MP0003705_abnormal_hypodermis_morpholog1.42931180
31MP0009697_abnormal_copulation1.38692868
32MP0003941_abnormal_skin_development1.36737072
33MP0005451_abnormal_body_composition1.35891455
34MP0003566_abnormal_cell_adhesion1.30464173
35MP0004036_abnormal_muscle_relaxation1.27915084
36MP0003950_abnormal_plasma_membrane1.26773740
37MP0005670_abnormal_white_adipose1.25926255
38MP0010155_abnormal_intestine_physiology1.24709198
39MP0000598_abnormal_liver_morphology1.24170691
40MP0005636_abnormal_mineral_homeostasis1.23561817
41MP0004087_abnormal_muscle_fiber1.22522725
42MP0000747_muscle_weakness1.21910474
43MP0005165_increased_susceptibility_to1.14059129
44MP0003656_abnormal_erythrocyte_physiolo1.07557600
45MP0005408_hypopigmentation1.01514100
46MP0001756_abnormal_urination0.99003882
47MP0004043_abnormal_pH_regulation0.97327107
48MP0002877_abnormal_melanocyte_morpholog0.95867076
49MP0005220_abnormal_exocrine_pancreas0.95651825
50MP0005084_abnormal_gallbladder_morpholo0.94756259
51MP0005257_abnormal_intraocular_pressure0.94223933
52MP0005666_abnormal_adipose_tissue0.94093591
53MP0002166_altered_tumor_susceptibility0.91667668
54MP0009763_increased_sensitivity_to0.91470967
55MP0005166_decreased_susceptibility_to0.91017963
56MP0002009_preneoplasia0.88926701
57MP0010368_abnormal_lymphatic_system0.88734558
58MP0004130_abnormal_muscle_cell0.88721205
59MP0005647_abnormal_sex_gland0.87627812
60MP0003183_abnormal_peptide_metabolism0.86199193
61MP0002876_abnormal_thyroid_physiology0.85885297
62MP0000490_abnormal_crypts_of0.85527536
63MP0000759_abnormal_skeletal_muscle0.85524636
64MP0006138_congestive_heart_failure0.84941119
65MP0002972_abnormal_cardiac_muscle0.84917497
66MP0002136_abnormal_kidney_physiology0.84739780
67MP0003011_delayed_dark_adaptation0.84442524
68MP0009642_abnormal_blood_homeostasis0.84047876
69MP0002896_abnormal_bone_mineralization0.84032408
70MP0004233_abnormal_muscle_weight0.84020682
71MP0008469_abnormal_protein_level0.83693466
72MP0005266_abnormal_metabolism0.83028832
73MP0002837_dystrophic_cardiac_calcinosis0.82278902
74MP0006035_abnormal_mitochondrial_morpho0.81335376
75MP0008004_abnormal_stomach_pH0.81199901
76MP0000477_abnormal_intestine_morphology0.80915341
77MP0009780_abnormal_chondrocyte_physiolo0.80330275
78MP0003453_abnormal_keratinocyte_physiol0.78319627
79MP0005376_homeostasis/metabolism_phenot0.78019020
80MP0009764_decreased_sensitivity_to0.77408411
81MP0002106_abnormal_muscle_physiology0.76372549
82MP0003091_abnormal_cell_migration0.76096773
83MP0004145_abnormal_muscle_electrophysio0.76007417
84MP0001881_abnormal_mammary_gland0.74686941
85MP0000858_altered_metastatic_potential0.73643889
86MP0001661_extended_life_span0.72821345
87MP0009053_abnormal_anal_canal0.72551417
88MP0005275_abnormal_skin_tensile0.71587470
89MP0005620_abnormal_muscle_contractility0.71139698
90MP0002971_abnormal_brown_adipose0.70270691
91MP0004147_increased_porphyrin_level0.69953643
92MP0002078_abnormal_glucose_homeostasis0.69796585
93MP0002332_abnormal_exercise_endurance0.69529935
94MP0005330_cardiomyopathy0.68108038
95MP0003866_abnormal_defecation0.66254959
96MP0004484_altered_response_of0.65830178
97MP0001663_abnormal_digestive_system0.65578082
98MP0004264_abnormal_extraembryonic_tissu0.64093136
99MP0004947_skin_inflammation0.63898428
100MP0005334_abnormal_fat_pad0.60774862
101MP0009765_abnormal_xenobiotic_induced0.59360627
102MP0003718_maternal_effect0.57849129
103MP0003221_abnormal_cardiomyocyte_apopto0.57497672
104MP0002269_muscular_atrophy0.55213741
105MP0005395_other_phenotype0.54563275
106MP0001765_abnormal_ion_homeostasis0.54415570
107MP0009672_abnormal_birth_weight0.54119566
108MP0001853_heart_inflammation0.53473031
109MP0009384_cardiac_valve_regurgitation0.52488140
110MP0010234_abnormal_vibrissa_follicle0.49490345
111MP0002254_reproductive_system_inflammat0.48100870
112MP0003567_abnormal_fetal_cardiomyocyte0.47626343
113MP0002928_abnormal_bile_duct0.46920025
114MP0002135_abnormal_kidney_morphology0.44095831
115MP0004084_abnormal_cardiac_muscle0.43727521
116MP0002970_abnormal_white_adipose0.43040849
117MP0003300_gastrointestinal_ulcer0.42968341
118MP0008873_increased_physiological_sensi0.42536780
119MP0005023_abnormal_wound_healing0.42454073
120MP0003646_muscle_fatigue0.42453471
121MP0009115_abnormal_fat_cell0.42122555
122MP0005058_abnormal_lysosome_morphology0.40829140
123MP0005464_abnormal_platelet_physiology0.40626646
124MP0000230_abnormal_systemic_arterial0.40516013
125MP0003638_abnormal_response/metabolism_0.40400496
126MP0003724_increased_susceptibility_to0.40384149
127MP0005535_abnormal_body_temperature0.39658560
128MP0010630_abnormal_cardiac_muscle0.37352497
129MP0002168_other_aberrant_phenotype0.35993746
130MP0001544_abnormal_cardiovascular_syste0.35816245
131MP0005385_cardiovascular_system_phenoty0.35816245
132MP0002396_abnormal_hematopoietic_system0.35420368
133MP0006054_spinal_hemorrhage0.35387126
134MP0004185_abnormal_adipocyte_glucose0.35096088
135MP0004782_abnormal_surfactant_physiolog0.35062491
136MP0003953_abnormal_hormone_level0.34757734
137MP0010352_gastrointestinal_tract_polyps0.34299339
138MP0002060_abnormal_skin_morphology0.33074320
139MP0005375_adipose_tissue_phenotype0.33054813
140MP0005448_abnormal_energy_balance0.33044456
141MP0002796_impaired_skin_barrier0.33042070

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.30555798
2Intrahepatic cholestasis (HP:0001406)6.27160915
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.77832203
4Deep venous thrombosis (HP:0002625)5.64842715
5Hypobetalipoproteinemia (HP:0003563)5.29936527
6Xanthomatosis (HP:0000991)5.24508917
7Hyperammonemia (HP:0001987)4.94802116
8Hyperglycinuria (HP:0003108)4.88362680
9Prolonged partial thromboplastin time (HP:0003645)4.82786250
10Hypoglycemic coma (HP:0001325)4.71588848
11Abnormality of serine family amino acid metabolism (HP:0010894)4.58529004
12Abnormality of glycine metabolism (HP:0010895)4.58529004
13Hyperglycinemia (HP:0002154)4.58306839
14Ketosis (HP:0001946)4.56611845
15Nemaline bodies (HP:0003798)4.32670706
16Hyperlipoproteinemia (HP:0010980)4.28454112
17Muscle fiber inclusion bodies (HP:0100299)4.27486157
18Abnormality of glutamine family amino acid metabolism (HP:0010902)4.18841639
19Abnormality of fatty-acid metabolism (HP:0004359)4.15573620
20Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.14537270
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.12245794
22Hypolipoproteinemia (HP:0010981)4.07095867
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.97072577
24Exercise-induced myalgia (HP:0003738)3.93545782
25Complement deficiency (HP:0004431)3.90350337
26Ketoacidosis (HP:0001993)3.81711257
27Abnormality of methionine metabolism (HP:0010901)3.80809445
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.70321397
29Abnormality of pyrimidine metabolism (HP:0004353)3.64297792
30Type 1 muscle fiber predominance (HP:0003803)3.56609053
31Hypoalphalipoproteinemia (HP:0003233)3.56407363
32Fat malabsorption (HP:0002630)3.56307322
33Abnormality of dicarboxylic acid metabolism (HP:0010995)3.55995928
34Dicarboxylic aciduria (HP:0003215)3.55995928
35Epidermoid cyst (HP:0200040)3.55107084
36Gout (HP:0001997)3.52600326
37Abnormality of the common coagulation pathway (HP:0010990)3.49713761
38Joint hemorrhage (HP:0005261)3.46112629
39Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.45974539
40Exercise-induced muscle cramps (HP:0003710)3.45398720
41Generalized aminoaciduria (HP:0002909)3.44109718
42Abnormality of serum amino acid levels (HP:0003112)3.36326654
43Abnormality of nucleobase metabolism (HP:0010932)3.35556827
44Delayed CNS myelination (HP:0002188)3.27422205
45Abnormality of the intrinsic pathway (HP:0010989)3.24715364
46Abnormality of purine metabolism (HP:0004352)3.21186344
47Hyperbilirubinemia (HP:0002904)3.13861781
48Metabolic acidosis (HP:0001942)3.10200575
49Lethargy (HP:0001254)3.05975086
50Right ventricular cardiomyopathy (HP:0011663)3.03916601
51Proximal tubulopathy (HP:0000114)3.02389624
52Hyperactive renin-angiotensin system (HP:0000841)2.94506558
53Conjugated hyperbilirubinemia (HP:0002908)2.94403939
54Hepatocellular carcinoma (HP:0001402)2.84630187
55Hypercholesterolemia (HP:0003124)2.84208993
56Abnormality of complement system (HP:0005339)2.81809930
57Cerebral edema (HP:0002181)2.78899483
58Flat acetabular roof (HP:0003180)2.72831010
59Centrally nucleated skeletal muscle fibers (HP:0003687)2.72613674
60Steatorrhea (HP:0002570)2.67879739
61Increased connective tissue (HP:0009025)2.62984505
62Spastic diplegia (HP:0001264)2.62525639
63Hyperuricemia (HP:0002149)2.61312522
64Increased purine levels (HP:0004368)2.61312522
65Distal lower limb muscle weakness (HP:0009053)2.60230742
66Nausea (HP:0002018)2.53761296
67Asymmetric septal hypertrophy (HP:0001670)2.52524316
68Hypoglycemic seizures (HP:0002173)2.52200604
69Neck muscle weakness (HP:0000467)2.49221044
70Abnormality of urine glucose concentration (HP:0011016)2.48538520
71Glycosuria (HP:0003076)2.48538520
72Myopathic facies (HP:0002058)2.47759760
73EMG: myopathic abnormalities (HP:0003458)2.44620343
74Vomiting (HP:0002013)2.42752402
75Nephritis (HP:0000123)2.42442458
76Late onset (HP:0003584)2.40042746
77Vascular calcification (HP:0004934)2.39244908
78Renal cortical cysts (HP:0000803)2.33336845
79Alkalosis (HP:0001948)2.32295424
80Abnormal cartilage morphology (HP:0002763)2.30063969
81Abnormality of skeletal muscle fiber size (HP:0012084)2.27125941
82Malnutrition (HP:0004395)2.25845545
83Hemorrhage of the eye (HP:0011885)2.25800698
84Skin nodule (HP:0200036)2.24328887
85Myoglobinuria (HP:0002913)2.22310569
86Mildly elevated creatine phosphokinase (HP:0008180)2.21891163
87Hepatic necrosis (HP:0002605)2.21073010
88Hypochromic microcytic anemia (HP:0004840)2.20633579
89Pancreatitis (HP:0001733)2.20021636
90Hyperinsulinemic hypoglycemia (HP:0000825)2.17842365
91Hyporeflexia of lower limbs (HP:0002600)2.17107946
92Irritability (HP:0000737)2.14965828
93Osteolytic defects of the phalanges of the hand (HP:0009771)2.14826012
94Osteolytic defects of the hand bones (HP:0009699)2.14826012
95Neonatal onset (HP:0003623)2.14550003
96Myocardial infarction (HP:0001658)2.13020634
97Cardiovascular calcification (HP:0011915)2.12271330
98Rhabdomyolysis (HP:0003201)2.09817562
99Muscle hypertrophy of the lower extremities (HP:0008968)2.09727904
100Vertebral compression fractures (HP:0002953)2.08987884
101Hydroxyprolinuria (HP:0003080)2.08986371
102Abnormality of proline metabolism (HP:0010907)2.08986371
103Muscle stiffness (HP:0003552)2.08208302
104Esophageal varix (HP:0002040)2.08106678
105Enlarged kidneys (HP:0000105)2.06131078
106Acanthocytosis (HP:0001927)2.05605787
107Increased serum pyruvate (HP:0003542)2.01710699
108Spontaneous abortion (HP:0005268)2.00969998
109Protrusio acetabuli (HP:0003179)2.00409685
110Ventricular tachycardia (HP:0004756)1.98913987
111Palpitations (HP:0001962)1.97275344
112Increased variability in muscle fiber diameter (HP:0003557)1.94454615
113Opisthotonus (HP:0002179)1.94056680
114Abnormality of glycolysis (HP:0004366)1.92902691
115Sensorimotor neuropathy (HP:0007141)1.92254099
116Systemic lupus erythematosus (HP:0002725)1.91425889
117Cholelithiasis (HP:0001081)1.90953267
118Abnormality of transition element cation homeostasis (HP:0011030)1.90305067
119Abnormal gallbladder morphology (HP:0012437)1.90087860
120Ileus (HP:0002595)1.89646173
121Mitral stenosis (HP:0001718)1.89227244
122Bundle branch block (HP:0011710)1.89070547
123Abnormal tarsal ossification (HP:0008369)1.88568322
124Abnormal enzyme/coenzyme activity (HP:0012379)1.87981679
125Abnormality of the Achilles tendon (HP:0005109)1.87548018
126Abnormality of iron homeostasis (HP:0011031)1.87382756
127Reduced antithrombin III activity (HP:0001976)1.86755076
128Elevated hepatic transaminases (HP:0002910)1.86593448
129Brushfield spots (HP:0001088)1.85780169
130Abnormality of the calf musculature (HP:0001430)1.85659922
131Calf muscle hypertrophy (HP:0008981)1.85533202
132Hyperglycemia (HP:0003074)1.82261674
133Ragged-red muscle fibers (HP:0003200)1.81839457
134Thrombophlebitis (HP:0004418)1.81370957
135Muscle fiber splitting (HP:0003555)1.80748001
136Dilated cardiomyopathy (HP:0001644)1.79084021
137Abnormality of carpal bone ossification (HP:0006257)1.78973788
138Rickets (HP:0002748)1.78674451
139Abdominal distention (HP:0003270)1.78596622
140Abnormality of vitamin metabolism (HP:0100508)1.75063918
141Sudden death (HP:0001699)1.75042362
142Round ear (HP:0100830)1.74833306
143Increased muscle lipid content (HP:0009058)1.74473829
144Symptomatic seizures (HP:0011145)1.74341678
145Glomerulonephritis (HP:0000099)1.74262299
146Distal lower limb amyotrophy (HP:0008944)1.73768675
147Methylmalonic aciduria (HP:0012120)1.72841119

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.76693704
2PKN23.28093306
3ERN12.84253908
4FLT32.82664881
5FGFR42.67762862
6SIK12.56108425
7TRIB32.39918207
8NEK12.07049927
9INSRR2.00386182
10MST1R1.86241970
11MST41.85717984
12PDK41.76934262
13PDK31.76934262
14STK241.75097773
15NEK91.74535727
16STK38L1.68572477
17LATS11.64821929
18KDR1.64119722
19WEE11.52641184
20PRPF4B1.50612659
21NME21.49933281
22TAOK31.47613551
23MAPK111.45789427
24WNK41.45672376
25FRK1.42707109
26MAP2K31.41623125
27EIF2AK11.33471521
28ACVR1B1.30592320
29PHKG21.29779655
30PHKG11.29779655
31ERBB41.29391089
32TESK11.28841591
33TGFBR11.27998213
34PBK1.26353738
35PTK61.25699081
36TIE11.24337497
37PIK3CG1.19220778
38MAP3K121.17717486
39PDK21.16339131
40BRSK21.13328776
41WNK31.13181576
42EPHB11.12603508
43TESK21.11789947
44TYK21.09543885
45TGFBR21.06494218
46FGFR31.05563001
47KSR21.03139601
48MAP3K31.02035263
49MAP3K141.01408610
50LRRK21.01145947
51CDK41.00303079
52TRPM71.00090871
53PRKAA20.99826577
54MAP3K130.97974813
55LMTK20.97461296
56NLK0.97233735
57MAP3K100.96878151
58JAK10.93501092
59EEF2K0.93266187
60PTK20.93244417
61DDR20.92621959
62TTK0.92235195
63ABL20.90892152
64TTN0.90774378
65RPS6KB20.90330715
66PIK3CA0.90003948
67MYLK0.89479426
68PINK10.89361509
69CDK60.85545213
70DMPK0.85020792
71ERBB30.83985546
72OBSCN0.83329114
73STK160.83273710
74SMG10.82788560
75MET0.82544522
76MOS0.82172114
77ICK0.82133478
78STK390.80056389
79MAP3K70.79441895
80STK100.77215430
81EPHA30.76851906
82LIMK10.75849872
83EIF2AK30.75555992
84EPHA20.71882406
85MAP3K20.70750103
86MAPKAPK30.70306761
87MAP3K80.69762435
88MAP3K10.67613274
89FER0.65967211
90JAK20.64654794
91RPS6KA40.62183424
92MAP3K110.61596170
93PDPK10.60993103
94EPHB20.60756580
95AURKB0.60662764
96NEK20.60393507
97PRKAA10.59946555
98TBK10.57953852
99BMPR20.57762716
100MAP2K60.56607330
101ERBB20.55287369
102STK30.54851863
103STK40.54079719
104LATS20.53999332
105GRK60.52300190
106CSF1R0.51142130
107MAPK40.50594856
108MAP2K20.49976339
109DYRK1B0.49764005
110CAMK1D0.49074350
111GSK3A0.48859869
112CDK70.48368734
113YES10.48217706
114CDC42BPA0.47195264
115PDGFRB0.45768067
116OXSR10.45065461
117MTOR0.43852777
118PAK40.43570278
119PIM10.42975870
120MAPK70.42684185
121MELK0.42673856
122KIT0.41983474
123PASK0.41717697
124PRKG20.40582265
125DYRK30.40239473
126ILK0.38553601
127MAPK120.38042329
128AKT30.37965966
129MAP3K50.37938110
130CAMK2G0.37801572
131MAP4K10.37599445
132AKT20.36338398
133MAPKAPK20.36017674
134PRKACG0.35839316
135TAOK20.35169274
136BMX0.35108739
137CAMK2D0.34611592
138SCYL20.34405991
139PAK20.34336738
140RIPK10.33873863
141BUB10.33669875
142PDGFRA0.33154370
143BTK0.32282031
144ZAP700.31792065
145MAPK150.31743517
146IRAK30.30817020

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.62396650
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.23922650
3Nitrogen metabolism_Homo sapiens_hsa009102.96292393
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.92617133
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.82859197
6Fatty acid degradation_Homo sapiens_hsa000712.81953732
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.80812324
8Tryptophan metabolism_Homo sapiens_hsa003802.55364354
9Arginine biosynthesis_Homo sapiens_hsa002202.51480185
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48204619
11* Propanoate metabolism_Homo sapiens_hsa006402.39227093
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.34961607
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33468908
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.23572425
15Butanoate metabolism_Homo sapiens_hsa006502.22191003
16Peroxisome_Homo sapiens_hsa041462.08965023
17Fatty acid metabolism_Homo sapiens_hsa012122.01207113
18Complement and coagulation cascades_Homo sapiens_hsa046102.01186039
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.89049146
20PPAR signaling pathway_Homo sapiens_hsa033201.79581247
21beta-Alanine metabolism_Homo sapiens_hsa004101.79003991
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.77651306
23Selenocompound metabolism_Homo sapiens_hsa004501.76668166
24Chemical carcinogenesis_Homo sapiens_hsa052041.71818084
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.70401115
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69775170
27Pyruvate metabolism_Homo sapiens_hsa006201.69067176
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67020721
29Caffeine metabolism_Homo sapiens_hsa002321.62908500
30* Carbon metabolism_Homo sapiens_hsa012001.61162563
31Histidine metabolism_Homo sapiens_hsa003401.58781200
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.56358302
33* Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54319703
34Biosynthesis of amino acids_Homo sapiens_hsa012301.51937890
35Folate biosynthesis_Homo sapiens_hsa007901.50304962
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49943049
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48240491
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.46563704
39Retinol metabolism_Homo sapiens_hsa008301.41665112
40Sulfur metabolism_Homo sapiens_hsa009201.39072984
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.37718748
42Starch and sucrose metabolism_Homo sapiens_hsa005001.34434438
43Phenylalanine metabolism_Homo sapiens_hsa003601.32124177
44Fatty acid elongation_Homo sapiens_hsa000621.27121222
45One carbon pool by folate_Homo sapiens_hsa006701.25742309
46Bile secretion_Homo sapiens_hsa049761.24404510
47Tyrosine metabolism_Homo sapiens_hsa003501.18514999
48Staphylococcus aureus infection_Homo sapiens_hsa051501.13916192
49Fat digestion and absorption_Homo sapiens_hsa049751.13220430
50Arginine and proline metabolism_Homo sapiens_hsa003301.10720704
51Sulfur relay system_Homo sapiens_hsa041221.07622472
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05199552
53Glutathione metabolism_Homo sapiens_hsa004801.01824349
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01395189
55ABC transporters_Homo sapiens_hsa020100.96208646
56Lysine degradation_Homo sapiens_hsa003100.95672083
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.95339257
58Vitamin digestion and absorption_Homo sapiens_hsa049770.94207096
59Pentose phosphate pathway_Homo sapiens_hsa000300.93003307
60Mineral absorption_Homo sapiens_hsa049780.91033934
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89441764
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87861763
63Vitamin B6 metabolism_Homo sapiens_hsa007500.78503002
64Steroid biosynthesis_Homo sapiens_hsa001000.77090239
65Glycerolipid metabolism_Homo sapiens_hsa005610.70480412
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64031336
67* Metabolic pathways_Homo sapiens_hsa011000.58057870
68Fructose and mannose metabolism_Homo sapiens_hsa000510.55287634
69Galactose metabolism_Homo sapiens_hsa000520.55211680
70Fatty acid biosynthesis_Homo sapiens_hsa000610.48420159
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42868521
72Thyroid cancer_Homo sapiens_hsa052160.36096134
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30591736
74Adherens junction_Homo sapiens_hsa045200.29340532
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28965505
76Pertussis_Homo sapiens_hsa051330.27663237
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.26857599
78Pyrimidine metabolism_Homo sapiens_hsa002400.26421223
79Insulin resistance_Homo sapiens_hsa049310.25809188
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25658978
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.25311719
82Tight junction_Homo sapiens_hsa045300.24211993
83DNA replication_Homo sapiens_hsa030300.23963602
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.20982015
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18339823
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18245979
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17866583
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17248738
89Linoleic acid metabolism_Homo sapiens_hsa005910.16624653
90Amoebiasis_Homo sapiens_hsa051460.15216066
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.14091342
92Mismatch repair_Homo sapiens_hsa034300.12484451
93Hepatitis C_Homo sapiens_hsa051600.12198580
94Pancreatic secretion_Homo sapiens_hsa049720.11934452
95Circadian rhythm_Homo sapiens_hsa047100.10663719
96AMPK signaling pathway_Homo sapiens_hsa041520.09526379
97Sphingolipid metabolism_Homo sapiens_hsa006000.06600577
98Glucagon signaling pathway_Homo sapiens_hsa049220.05829247
99Renin-angiotensin system_Homo sapiens_hsa046140.03286956
100Ribosome_Homo sapiens_hsa030100.01471867
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.00571005
102Purine metabolism_Homo sapiens_hsa00230-0.0954812
103Insulin signaling pathway_Homo sapiens_hsa04910-0.0909157
104Nucleotide excision repair_Homo sapiens_hsa03420-0.0901627
105Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0884036
106Other glycan degradation_Homo sapiens_hsa00511-0.0721595
107Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0682418
108Prion diseases_Homo sapiens_hsa05020-0.0623058
109Parkinsons disease_Homo sapiens_hsa05012-0.0407440
110Base excision repair_Homo sapiens_hsa03410-0.0336041
111Proteasome_Homo sapiens_hsa03050-0.0282530
112Protein digestion and absorption_Homo sapiens_hsa04974-0.0172521
113Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0157124
114Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0142773
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0098876
116Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0071697

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