STYK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.21070216
2bundle of His cell to Purkinje myocyte communication (GO:0086069)5.77624037
3intestinal epithelial cell development (GO:0060576)5.67615363
4superoxide anion generation (GO:0042554)5.35419886
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.46035810
6diterpenoid biosynthetic process (GO:0016102)4.34494335
7UDP-N-acetylglucosamine metabolic process (GO:0006047)4.23269743
8hemidesmosome assembly (GO:0031581)4.13407059
9detection of other organism (GO:0098543)4.09073444
10nucleotide-sugar biosynthetic process (GO:0009226)4.07343172
11O-glycan processing (GO:0016266)4.02103469
12positive regulation of cellular amide metabolic process (GO:0034250)3.95596410
13cellular glucuronidation (GO:0052695)3.93389746
14membrane budding (GO:0006900)3.90308327
15vitamin transmembrane transport (GO:0035461)3.81597313
16inositol phosphate-mediated signaling (GO:0048016)3.78076732
17keratinocyte proliferation (GO:0043616)3.75978998
18regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.75602925
19detection of bacterium (GO:0016045)3.75067640
20dendritic cell chemotaxis (GO:0002407)3.72687342
21oligosaccharide biosynthetic process (GO:0009312)3.68355267
22regulation of guanylate cyclase activity (GO:0031282)3.64912601
23glucuronate metabolic process (GO:0019585)3.62553354
24uronic acid metabolic process (GO:0006063)3.62553354
25keratinocyte development (GO:0003334)3.57708809
26dendritic cell migration (GO:0036336)3.54650441
27zinc ion transport (GO:0006829)3.53839485
28cytoskeletal anchoring at plasma membrane (GO:0007016)3.52864457
29multicellular organismal water homeostasis (GO:0050891)3.49785577
30regulation of RIG-I signaling pathway (GO:0039535)3.49446035
31superoxide metabolic process (GO:0006801)3.44864815
32regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.44781606
33positive regulation of interleukin-1 beta secretion (GO:0050718)3.42910294
34response to host immune response (GO:0052572)3.38393501
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.38393501
36regulation of water loss via skin (GO:0033561)3.38250216
37regulation of activation of Janus kinase activity (GO:0010533)3.32596073
38pyrimidine-containing compound transmembrane transport (GO:0072531)3.29720195
39zinc ion transmembrane transport (GO:0071577)3.28553707
40flavonoid metabolic process (GO:0009812)3.27528591
41interferon-gamma production (GO:0032609)3.26706000
42modulation by symbiont of host defense response (GO:0052031)3.26521004
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.26521004
44modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.26521004
45positive regulation by organism of defense response of other organism involved in symbiotic interact3.26521004
46modulation by symbiont of host immune response (GO:0052553)3.26521004
47positive regulation by symbiont of host defense response (GO:0052509)3.26521004
483-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.26376933
49purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.26376933
50establishment of skin barrier (GO:0061436)3.26341367
51positive regulation of interferon-alpha production (GO:0032727)3.26221449
52negative regulation of mast cell activation (GO:0033004)3.20469947
53cellular response to exogenous dsRNA (GO:0071360)3.20281533
54positive regulation of protein autophosphorylation (GO:0031954)3.18598048
55response to gravity (GO:0009629)3.17963012
56positive regulation of interleukin-1 secretion (GO:0050716)3.17777288
57membrane raft organization (GO:0031579)3.16025923
58neutrophil activation involved in immune response (GO:0002283)3.14778078
59ER overload response (GO:0006983)3.13113752
60regulation of interleukin-1 beta secretion (GO:0050706)3.11133624
61neutrophil activation (GO:0042119)3.11002593
62regulation of transforming growth factor beta2 production (GO:0032909)3.10406524
63negative regulation of protein localization to cell surface (GO:2000009)3.08310185
64response to peptidoglycan (GO:0032494)3.07154386
65lung lobe morphogenesis (GO:0060463)3.06102472
66regulation of interleukin-8 secretion (GO:2000482)3.04255699
67regulation of interferon-alpha production (GO:0032647)3.04142178
68calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.04003524
69positive regulation of epidermal cell differentiation (GO:0045606)3.02292376
70detection of molecule of bacterial origin (GO:0032490)2.98713022
71G-protein coupled receptor internalization (GO:0002031)2.98146360
72nucleotide transmembrane transport (GO:1901679)2.97541330
73intestinal absorption (GO:0050892)2.95434090
74response to host (GO:0075136)2.95404949
75response to host defenses (GO:0052200)2.95404949
76response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.95404949
77negative regulation of viral genome replication (GO:0045071)2.94196975
78detection of external biotic stimulus (GO:0098581)2.94130572
79regulation of transforming growth factor beta1 production (GO:0032908)2.93481440
80ventricular cardiac muscle cell action potential (GO:0086005)2.90730238
81regulation of keratinocyte proliferation (GO:0010837)2.90418670
82water homeostasis (GO:0030104)2.90171368
83negative regulation of T cell differentiation in thymus (GO:0033085)2.89470617
84negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.89361887
85G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.89189229
86negative regulation of protein tyrosine kinase activity (GO:0061099)2.89059836
87nucleotide-sugar metabolic process (GO:0009225)2.88397380
88granulocyte activation (GO:0036230)2.88295821
89sphingomyelin metabolic process (GO:0006684)2.88131277
90positive regulation of guanylate cyclase activity (GO:0031284)2.86753925
91sulfate transport (GO:0008272)2.86159733
92cellular response to interferon-beta (GO:0035458)2.86065665
93striated muscle atrophy (GO:0014891)2.85752365
94regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.82689482
95regulation of protein glycosylation (GO:0060049)2.82312358
96sulfate transmembrane transport (GO:1902358)2.81516069
97negative regulation of keratinocyte proliferation (GO:0010839)2.81343140
98negative regulation of actin filament depolymerization (GO:0030835)2.80614943
99positive regulation of heat generation (GO:0031652)2.78558359
100histamine transport (GO:0051608)2.78345383
101cellular response to type I interferon (GO:0071357)2.77331564
102type I interferon signaling pathway (GO:0060337)2.77331564
103positive regulation of glycoprotein metabolic process (GO:1903020)2.77206560
104regulation of actin filament depolymerization (GO:0030834)2.77113274
105positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.76159627
106response to type I interferon (GO:0034340)2.75629799
107positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.71900758
108angiotensin maturation (GO:0002003)2.71687428
109cilium or flagellum-dependent cell motility (GO:0001539)2.71625387
110hypotonic response (GO:0006971)2.70926422
111terpenoid biosynthetic process (GO:0016114)2.70333184
112positive regulation of monocyte chemotaxis (GO:0090026)2.70092279
113regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.68353534
114execution phase of apoptosis (GO:0097194)2.67031176
115positive regulation of glycoprotein biosynthetic process (GO:0010560)2.66770840
116glycosylceramide metabolic process (GO:0006677)2.65670860
117regulation of dendritic cell antigen processing and presentation (GO:0002604)2.64793920
118positive regulation of interleukin-1 beta production (GO:0032731)2.64180888
119proline transport (GO:0015824)2.64021781
120negative regulation of stem cell proliferation (GO:2000647)2.63352951
121CDP-diacylglycerol biosynthetic process (GO:0016024)2.63278757
122tight junction assembly (GO:0070830)2.62996925
123actin filament capping (GO:0051693)2.62952858
124positive regulation of macrophage activation (GO:0043032)2.62363409
125DNA integration (GO:0015074)2.62237182
126regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.61255840
127endocrine process (GO:0050886)2.61255840
128regulation of systemic arterial blood pressure by hormone (GO:0001990)2.61255840
129drug catabolic process (GO:0042737)2.61122997
130regulation of interleukin-1 secretion (GO:0050704)2.60950925
131NADH metabolic process (GO:0006734)2.60870741
132centriole assembly (GO:0098534)2.59953318
133hepatocyte apoptotic process (GO:0097284)2.59669849
134replicative senescence (GO:0090399)2.58962708
135positive regulation of antigen processing and presentation (GO:0002579)2.57518025
136detection of biotic stimulus (GO:0009595)2.57296572
137COPII vesicle coating (GO:0048208)2.57068491
138positive regulation of defense response to virus by host (GO:0002230)2.57018263
139positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.55905045
140positive regulation of vesicle fusion (GO:0031340)2.55885599
141regulation of protein localization to cell surface (GO:2000008)2.55723051
142receptor guanylyl cyclase signaling pathway (GO:0007168)2.55583819
143response to muramyl dipeptide (GO:0032495)2.55086218
144positive regulation of T cell migration (GO:2000406)2.54358058
145protein heterotetramerization (GO:0051290)2.54300729
146regulation of mast cell activation (GO:0033003)2.53914877
147regulation of keratinocyte differentiation (GO:0045616)2.53043229
148immunoglobulin mediated immune response (GO:0016064)2.52543422
149sphingoid metabolic process (GO:0046519)2.52120092
150response to interferon-alpha (GO:0035455)2.51466539
151hepatocyte differentiation (GO:0070365)2.51066572
152positive regulation of interleukin-1 production (GO:0032732)2.50973989
153cell-cell junction assembly (GO:0007043)2.50445486
154energy homeostasis (GO:0097009)2.50350757
155positive regulation of actin filament depolymerization (GO:0030836)2.49958625
156positive regulation of lymphocyte migration (GO:2000403)2.49784786
157mesenchymal cell differentiation involved in renal system development (GO:2001012)2.49507247
158mesenchymal cell differentiation involved in kidney development (GO:0072161)2.49507247
159meiotic chromosome segregation (GO:0045132)2.49092085
160positive regulation of gamma-delta T cell activation (GO:0046645)2.48786186
161microglial cell activation (GO:0001774)2.48218998
162regulation of transforming growth factor beta production (GO:0071634)2.47252860
163regulation of metalloenzyme activity (GO:0048552)2.46991488
164production of molecular mediator involved in inflammatory response (GO:0002532)2.46589228
165oligosaccharide catabolic process (GO:0009313)2.45259276
166transcytosis (GO:0045056)2.45148408
167protein O-linked glycosylation (GO:0006493)2.44586196
168negative regulation of granulocyte differentiation (GO:0030853)2.44147396
169regulation of fever generation (GO:0031620)2.43773257
170GDP-mannose metabolic process (GO:0019673)2.42943192
171regulation of bile acid biosynthetic process (GO:0070857)2.42844086
172regulation of T cell chemotaxis (GO:0010819)2.42474841
173positive regulation of T cell chemotaxis (GO:0010820)2.42474841
174positive regulation of interferon-gamma production (GO:0032729)2.42471450
175cellular extravasation (GO:0045123)2.41795430
176muscle atrophy (GO:0014889)2.41522977
177sperm capacitation (GO:0048240)2.41480144
178actin filament depolymerization (GO:0030042)2.41246568
179sulfur compound transport (GO:0072348)2.41099179
180sphingosine metabolic process (GO:0006670)2.40484710
181positive regulation of smooth muscle cell migration (GO:0014911)2.40450979
182positive regulation of interferon-beta production (GO:0032728)2.40283205
183auditory receptor cell stereocilium organization (GO:0060088)2.39709022
184myeloid dendritic cell activation (GO:0001773)2.39567634
185interferon-gamma-mediated signaling pathway (GO:0060333)2.38741128
186histamine secretion (GO:0001821)2.37097313
187extracellular regulation of signal transduction (GO:1900115)2.37077881
188extracellular negative regulation of signal transduction (GO:1900116)2.37077881
189diol metabolic process (GO:0034311)2.36899018
190positive regulation of humoral immune response (GO:0002922)2.34629782
191positive regulation of interleukin-12 production (GO:0032735)2.34258237
192regulation of chemokine secretion (GO:0090196)2.33528059
193regulation of cellular extravasation (GO:0002691)2.33120874
194female gonad development (GO:0008585)2.33058064

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.24190197
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.02256703
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.49030693
4GBX2_23144817_ChIP-Seq_PC3_Human3.32281987
5PCGF2_27294783_Chip-Seq_ESCs_Mouse3.08280867
6CDX2_20551321_ChIP-Seq_CACO-2_Human3.07404234
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.07193659
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.02907826
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.94534995
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.90845317
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.84853449
12SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.77973671
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.77973671
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.74772598
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.73229312
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.68129125
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.66008056
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.63176365
19SUZ12_27294783_Chip-Seq_NPCs_Mouse2.59750087
20FOXO3_23340844_ChIP-Seq_DLD1_Human2.57238297
21* SOX2_20726797_ChIP-Seq_SW620_Human2.54922762
22PCGF2_27294783_Chip-Seq_NPCs_Mouse2.53513324
23NFE2_27457419_Chip-Seq_LIVER_Mouse2.48224006
24* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.45799154
25ESR1_20079471_ChIP-ChIP_T-47D_Human2.39974551
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.39753818
27PPAR_26484153_Chip-Seq_NCI-H1993_Human2.39558987
28* GATA6_25053715_ChIP-Seq_YYC3_Human2.36959878
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.36909624
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.35104103
31FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human2.22738560
32EZH2_27294783_Chip-Seq_NPCs_Mouse2.20791639
33GATA4_25053715_ChIP-Seq_YYC3_Human2.14461082
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.14046940
35POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10396662
36HIF1A_21447827_ChIP-Seq_MCF-7_Human2.07978113
37AR_21909140_ChIP-Seq_LNCAP_Human2.07111524
38EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse2.00279986
39STAT3_18555785_Chip-Seq_ESCs_Mouse1.96515768
40NANOG_18555785_Chip-Seq_ESCs_Mouse1.94787659
41SUZ12_18555785_Chip-Seq_ESCs_Mouse1.94464978
42P53_22387025_ChIP-Seq_ESCs_Mouse1.94323259
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.94213060
44FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.92558732
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.91593984
46E2F1_18555785_Chip-Seq_ESCs_Mouse1.90792172
47IGF1R_20145208_ChIP-Seq_DFB_Human1.90503573
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.89267490
49CJUN_26792858_Chip-Seq_BT549_Human1.88384393
50AHR_22903824_ChIP-Seq_MCF-7_Human1.87739171
51GATA3_24758297_ChIP-Seq_MCF-7_Human1.84452002
52NMYC_18555785_Chip-Seq_ESCs_Mouse1.82733418
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81286253
54AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.80733007
55CMYC_18555785_Chip-Seq_ESCs_Mouse1.77739475
56STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76417033
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.74562486
58* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.72519082
59EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.71783604
60P300_18555785_Chip-Seq_ESCs_Mouse1.70218338
61OCT4_18555785_Chip-Seq_ESCs_Mouse1.70023146
62* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.67814821
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67523533
64SOX2_18555785_Chip-Seq_ESCs_Mouse1.65462122
65PU1_27457419_Chip-Seq_LIVER_Mouse1.64998401
66CDX2_22108803_ChIP-Seq_LS180_Human1.64462068
67RUNX1_27457419_Chip-Seq_LIVER_Mouse1.63695139
68IRF8_27001747_Chip-Seq_BMDM_Mouse1.63482468
69TP63_23658742_ChIP-Seq_EP156T_Human1.62864730
70FOXA1_25552417_ChIP-Seq_VCAP_Human1.62317238
71CTNNB1_20460455_ChIP-Seq_HCT116_Human1.60919186
72ZFX_18555785_Chip-Seq_ESCs_Mouse1.59481380
73ESRRB_18555785_Chip-Seq_ESCs_Mouse1.58243695
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57638632
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.55349638
76KLF5_25053715_ChIP-Seq_YYC3_Human1.54738841
77CTCF_18555785_Chip-Seq_ESCs_Mouse1.52013764
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.51777160
79P300_19829295_ChIP-Seq_ESCs_Human1.50874912
80KLF4_18555785_Chip-Seq_ESCs_Mouse1.50824120
81P63_26484246_Chip-Seq_KERATINOCYTES_Human1.50786258
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50030788
83* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49912206
84TP53_16413492_ChIP-PET_HCT116_Human1.49602339
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49491495
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.49317121
87OCT4_21477851_ChIP-Seq_ESCs_Mouse1.49239470
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48977148
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48891732
90JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47866995
91SMAD1_18555785_Chip-Seq_ESCs_Mouse1.46478790
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.45652146
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44590923
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43974253
95ELF5_23300383_ChIP-Seq_T47D_Human1.43818804
96SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43427848
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.43265973
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42037738
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.41863502
100* TAL1_26923725_Chip-Seq_HPCs_Mouse1.41451203
101TRIM28_21343339_ChIP-Seq_HEK293_Human1.41098291
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41072002
103SOX9_24532713_ChIP-Seq_HFSC_Mouse1.40453026
104JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38401787
105ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.37617042
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37162046
107KAP1_22055183_ChIP-Seq_ESCs_Mouse1.36874759
108ATF3_27146783_Chip-Seq_COLON_Human1.32896539
109SMAD4_21799915_ChIP-Seq_A2780_Human1.30543130
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28154397
111HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26250112
112RUNX1_27514584_Chip-Seq_MCF-7_Human1.25313479
113* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24766277
114* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24766277
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24686458
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24139404
117BRD4_25478319_ChIP-Seq_HGPS_Human1.22849960
118FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.22210208
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21530962
120KDM2B_26808549_Chip-Seq_REH_Human1.20263921
121* STAT3_23295773_ChIP-Seq_U87_Human1.19720970
122TP53_18474530_ChIP-ChIP_U2OS_Human1.19113987
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17731598
124CBX2_27304074_Chip-Seq_ESCs_Mouse1.17650461
125EWS_26573619_Chip-Seq_HEK293_Human1.16245032
126FUS_26573619_Chip-Seq_HEK293_Human1.14707330
127PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13936423
128ER_23166858_ChIP-Seq_MCF-7_Human1.13626035
129TCF4_18268006_ChIP-ChIP_LS174T_Human1.12612791
130FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11817272
131STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10020856
132DROSHA_22980978_ChIP-Seq_HELA_Human1.09771599
133TCF4_22108803_ChIP-Seq_LS180_Human1.09542478
134TP63_19390658_ChIP-ChIP_HaCaT_Human1.07734472
135* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06992784
136RNF2_27304074_Chip-Seq_NSC_Mouse1.06063555
137ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05564429
138TCF4_23295773_ChIP-Seq_U87_Human1.05134727
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04870457
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04870457
141CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04767492
142PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04720623
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04555227
144AR_25329375_ChIP-Seq_VCAP_Human1.04270711
145VDR_24787735_ChIP-Seq_THP-1_Human1.03126635
146EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02899005
147STAT1_17558387_ChIP-Seq_HELA_Human1.02454982
148LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01225096
149BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99935389
150CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99389950
151MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98407039
152FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98379986
153FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98223202
154BCAT_22108803_ChIP-Seq_LS180_Human0.98016021
155RXR_22108803_ChIP-Seq_LS180_Human0.97585104
156* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97013599
157UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95886550
158RUNX2_22187159_ChIP-Seq_PCA_Human0.95261814
159TP63_17297297_ChIP-ChIP_HaCaT_Human0.95197519
160VDR_22108803_ChIP-Seq_LS180_Human0.94654699
161TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94041304
162GATA2_21666600_ChIP-Seq_HMVEC_Human0.93779623
163NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93701039
164SMAD3_21741376_ChIP-Seq_EPCs_Human0.92945810
165NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90970450
166PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90116442
167LXR_22158963_ChIP-Seq_LIVER_Mouse0.87449385
168GATA2_19941826_ChIP-Seq_K562_Human0.86964285
169IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83172167
170CBP_20019798_ChIP-Seq_JUKART_Human0.83172167
171NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.82013585
172ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.79027323
173CHD1_26751641_Chip-Seq_LNCaP_Human0.77622059
174CEBPB_22108803_ChIP-Seq_LS180_Human0.76919860

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.78698841
2MP0009780_abnormal_chondrocyte_physiolo4.52150106
3MP0005360_urolithiasis4.04600059
4MP0001188_hyperpigmentation3.57549745
5MP0001835_abnormal_antigen_presentation3.27120194
6MP0009785_altered_susceptibility_to3.24126018
7MP0004147_increased_porphyrin_level3.09525501
8MP0010352_gastrointestinal_tract_polyps3.04781301
9MP0000569_abnormal_digit_pigmentation2.94684813
10MP0002148_abnormal_hypersensitivity_rea2.90610509
11MP0005671_abnormal_response_to2.78228861
12MP0002796_impaired_skin_barrier2.62638770
13MP0010386_abnormal_urinary_bladder2.61432989
14MP0002277_abnormal_respiratory_mucosa2.41600083
15MP0005501_abnormal_skin_physiology2.39730145
16MP0000015_abnormal_ear_pigmentation2.33748577
17MP0002876_abnormal_thyroid_physiology2.30363600
18MP0000566_synostosis2.24748909
19MP0009697_abnormal_copulation2.18577802
20MP0008004_abnormal_stomach_pH2.15227572
21MP0005025_abnormal_response_to2.14956382
22MP0004782_abnormal_surfactant_physiolog2.14843264
23MP0010678_abnormal_skin_adnexa2.14089980
24MP0006082_CNS_inflammation2.10671748
25MP0002419_abnormal_innate_immunity2.09166587
26MP0002102_abnormal_ear_morphology2.07341288
27MP0008875_abnormal_xenobiotic_pharmacok2.05378464
28MP0003724_increased_susceptibility_to2.04240986
29MP0005646_abnormal_pituitary_gland2.03553068
30MP0001790_abnormal_immune_system1.99567527
31MP0005387_immune_system_phenotype1.99567527
32MP0003787_abnormal_imprinting1.99406453
33MP0005451_abnormal_body_composition1.98825863
34MP0005085_abnormal_gallbladder_physiolo1.97959564
35MP0000490_abnormal_crypts_of1.97663546
36MP0010155_abnormal_intestine_physiology1.95972535
37MP0009764_decreased_sensitivity_to1.93883142
38MP0005645_abnormal_hypothalamus_physiol1.91686626
39MP0005171_absent_coat_pigmentation1.91065184
40MP0006292_abnormal_olfactory_placode1.90607185
41MP0004043_abnormal_pH_regulation1.90041821
42MP0005000_abnormal_immune_tolerance1.85949631
43MP0005423_abnormal_somatic_nervous1.84671453
44MP0002132_abnormal_respiratory_system1.83856737
45MP0003436_decreased_susceptibility_to1.83041246
46MP0002452_abnormal_antigen_presenting1.80326348
47MP0001666_abnormal_nutrient_absorption1.79915057
48MP0001501_abnormal_sleep_pattern1.77436039
49MP0001664_abnormal_digestion1.72865305
50MP0002723_abnormal_immune_serum1.70278888
51MP0001800_abnormal_humoral_immune1.67974799
52MP0001346_abnormal_lacrimal_gland1.66779756
53MP0001765_abnormal_ion_homeostasis1.65928434
54MP0005174_abnormal_tail_pigmentation1.63243424
55MP0001216_abnormal_epidermal_layer1.61127425
56MP0001819_abnormal_immune_cell1.59657435
57MP0002006_tumorigenesis1.58307831
58MP0001873_stomach_inflammation1.57815919
59MP0010771_integument_phenotype1.56836999
60MP0002420_abnormal_adaptive_immunity1.55631079
61MP0002168_other_aberrant_phenotype1.53284798
62MP0003136_yellow_coat_color1.52053259
63MP0001986_abnormal_taste_sensitivity1.51344547
64MP0008058_abnormal_DNA_repair1.49997912
65MP0005395_other_phenotype1.48294658
66MP0000537_abnormal_urethra_morphology1.43577566
67MP0005166_decreased_susceptibility_to1.39752783
68MP0008057_abnormal_DNA_replication1.39660226
69MP0000538_abnormal_urinary_bladder1.39321458
70MP0003806_abnormal_nucleotide_metabolis1.37978791
71MP0005076_abnormal_cell_differentiation1.35970061
72MP0005310_abnormal_salivary_gland1.34622016
73MP0003183_abnormal_peptide_metabolism1.32894340
74MP0002396_abnormal_hematopoietic_system1.30699681
75MP0005464_abnormal_platelet_physiology1.30017506
76MP0005636_abnormal_mineral_homeostasis1.28664567
77MP0004270_analgesia1.28251300
78MP0002163_abnormal_gland_morphology1.27955386
79MP0003941_abnormal_skin_development1.27445553
80MP0001191_abnormal_skin_condition1.26997453
81MP0000383_abnormal_hair_follicle1.22950309
82MP0004381_abnormal_hair_follicle1.22044723
83MP0000467_abnormal_esophagus_morphology1.20159867
84MP0005023_abnormal_wound_healing1.20094099
85MP0002998_abnormal_bone_remodeling1.19259207
86MP0001845_abnormal_inflammatory_respons1.18237175
87MP0000372_irregular_coat_pigmentation1.17422881
88MP0005409_darkened_coat_color1.16899128
89MP0003566_abnormal_cell_adhesion1.15240979
90MP0002009_preneoplasia1.13984017
91MP0001119_abnormal_female_reproductive1.13378346
92MP0003828_pulmonary_edema1.13008042
93MP0000627_abnormal_mammary_gland1.11833366
94MP0000613_abnormal_salivary_gland1.11082448
95MP0001663_abnormal_digestive_system1.10903813
96MP0002095_abnormal_skin_pigmentation1.09704024
97MP0009643_abnormal_urine_homeostasis1.07205507
98MP0005257_abnormal_intraocular_pressure1.06643572
99MP0001881_abnormal_mammary_gland1.05276375
100MP0000762_abnormal_tongue_morphology1.04474859
101MP0008260_abnormal_autophagy1.03101582
102MP0000579_abnormal_nail_morphology1.00565094
103MP0002405_respiratory_system_inflammati1.00328036
104MP0000716_abnormal_immune_system0.99698466
105MP0002098_abnormal_vibrissa_morphology0.99457867
106MP0001502_abnormal_circadian_rhythm0.99274540
107MP0003693_abnormal_embryo_hatching0.99096765
108MP0000685_abnormal_immune_system0.98318584
109MP0004947_skin_inflammation0.98079116
110MP0001186_pigmentation_phenotype0.97480423
111MP0003866_abnormal_defecation0.97376750
112MP0003763_abnormal_thymus_physiology0.97170682
113MP0002138_abnormal_hepatobiliary_system0.96449728
114MP0004019_abnormal_vitamin_homeostasis0.96352217
115MP0003191_abnormal_cellular_cholesterol0.95469890
116MP0002638_abnormal_pupillary_reflex0.92968439
117MP0000470_abnormal_stomach_morphology0.92825109
118MP0010307_abnormal_tumor_latency0.92676680
119MP0003045_fibrosis0.91690441
120MP0005165_increased_susceptibility_to0.90857603
121MP0000477_abnormal_intestine_morphology0.90206927
122MP0003195_calcinosis0.89844502
123MP0002398_abnormal_bone_marrow0.89667775
124MP0001533_abnormal_skeleton_physiology0.89240727
125MP0002166_altered_tumor_susceptibility0.88519118
126MP0003448_altered_tumor_morphology0.86802292
127MP0000371_diluted_coat_color0.86736340
128MP0005365_abnormal_bile_salt0.86674427
129MP0000681_abnormal_thyroid_gland0.86293618
130MP0000427_abnormal_hair_cycle0.84656168
131MP0000377_abnormal_hair_follicle0.84608858
132MP0008469_abnormal_protein_level0.83510146
133MP0003656_abnormal_erythrocyte_physiolo0.83010549
134MP0005075_abnormal_melanosome_morpholog0.82891556
135MP0003950_abnormal_plasma_membrane0.81981415
136MP0004484_altered_response_of0.81899741
137MP0002928_abnormal_bile_duct0.81552739
138MP0000678_abnormal_parathyroid_gland0.81367055
139MP0002136_abnormal_kidney_physiology0.80020769
140MP0002736_abnormal_nociception_after0.79383612
141MP0003453_abnormal_keratinocyte_physiol0.77017174
142MP0010368_abnormal_lymphatic_system0.76803861
143MP0004185_abnormal_adipocyte_glucose0.76347734
144MP0000858_altered_metastatic_potential0.75517765
145MP0005381_digestive/alimentary_phenotyp0.74478228
146MP0002060_abnormal_skin_morphology0.74110839
147MP0005647_abnormal_sex_gland0.73966948
148MP0004957_abnormal_blastocyst_morpholog0.73156272
149MP0001764_abnormal_homeostasis0.72982724
150MP0003868_abnormal_feces_composition0.72777445
151MP0000343_altered_response_to0.70275572
152MP0002938_white_spotting0.70190195
153MP0003705_abnormal_hypodermis_morpholog0.70073337
154MP0005621_abnormal_cell_physiology0.69521912
155MP0002429_abnormal_blood_cell0.68162382
156MP0001853_heart_inflammation0.67926539
157MP0003718_maternal_effect0.67060072
158MP0004264_abnormal_extraembryonic_tissu0.66945255
159MP0003880_abnormal_central_pattern0.66901754
160MP0002160_abnormal_reproductive_system0.66829649
161MP0006054_spinal_hemorrhage0.63423847
162MP0004272_abnormal_basement_membrane0.62744836
163MP0000230_abnormal_systemic_arterial0.62324277
164MP0005670_abnormal_white_adipose0.60552937
165MP0008873_increased_physiological_sensi0.60242003
166MP0006138_congestive_heart_failure0.59376172
167MP0002896_abnormal_bone_mineralization0.58512761
168MP0001968_abnormal_touch/_nociception0.58244005
169MP0000465_gastrointestinal_hemorrhage0.57136238
170MP0002909_abnormal_adrenal_gland0.55403916

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)5.81340844
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.63747541
3Chromsome breakage (HP:0040012)5.16892936
4Right ventricular cardiomyopathy (HP:0011663)4.81774043
5Prostate neoplasm (HP:0100787)4.81241390
6Popliteal pterygium (HP:0009756)4.30798779
7Flat acetabular roof (HP:0003180)4.02413016
8Retrobulbar optic neuritis (HP:0100654)4.00452936
9Optic neuritis (HP:0100653)4.00452936
10Recurrent abscess formation (HP:0002722)3.86624438
11Cone-rod dystrophy (HP:0000548)3.67342396
12Entropion (HP:0000621)3.64852163
13Abnormality of glutamine family amino acid metabolism (HP:0010902)3.57719350
14Chronic bronchitis (HP:0004469)3.44539984
15Orchitis (HP:0100796)3.32751448
16Poikiloderma (HP:0001029)3.29574156
17Pili torti (HP:0003777)3.23300207
18Eczematoid dermatitis (HP:0000976)3.21132815
19Myositis (HP:0100614)3.21129337
20Spinal cord compression (HP:0002176)3.18576746
21Hydroxyprolinuria (HP:0003080)3.15909971
22Abnormality of proline metabolism (HP:0010907)3.15909971
23Abnormality of renin-angiotensin system (HP:0000847)3.15049075
24Decreased circulating renin level (HP:0003351)3.14836914
25Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.11859387
26Abnormality of chloride homeostasis (HP:0011422)3.08808796
27Congenital sensorineural hearing impairment (HP:0008527)3.07853258
28Hyperaldosteronism (HP:0000859)3.05435740
29Metabolic alkalosis (HP:0200114)3.05192072
30Abnormality of the neuromuscular junction (HP:0003398)3.04090708
31Fatigable weakness (HP:0003473)3.04090708
32Hyponatremia (HP:0002902)3.00031842
33Recurrent bacterial skin infections (HP:0005406)2.98378422
34Abnormality of the prostate (HP:0008775)2.93859232
35Clubbing of toes (HP:0100760)2.88966817
36Chronic diarrhea (HP:0002028)2.84336736
37Febrile seizures (HP:0002373)2.78268774
38Amniotic constriction ring (HP:0009775)2.77052286
39Abnormality of placental membranes (HP:0011409)2.77052286
40Alopecia of scalp (HP:0002293)2.76123544
41Duplicated collecting system (HP:0000081)2.75920011
42Amelogenesis imperfecta (HP:0000705)2.67708432
43Malnutrition (HP:0004395)2.67400257
44Abnormality of the renal collecting system (HP:0004742)2.67113838
45Alveolar cell carcinoma (HP:0006519)2.65926443
46Chronic hepatic failure (HP:0100626)2.64796301
47Cardiovascular calcification (HP:0011915)2.64343780
48Type 2 muscle fiber atrophy (HP:0003554)2.62359966
49Vascular calcification (HP:0004934)2.58186832
50Onycholysis (HP:0001806)2.57720467
51Gingivitis (HP:0000230)2.57273232
52Abnormality of the preputium (HP:0100587)2.52812016
53Hand muscle atrophy (HP:0009130)2.52723594
54Glucose intolerance (HP:0000833)2.52466259
55Distal upper limb amyotrophy (HP:0007149)2.52179535
56Upper limb amyotrophy (HP:0009129)2.52179535
57Renal cortical cysts (HP:0000803)2.51368053
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.50787819
59Abnormality of DNA repair (HP:0003254)2.47709871
60Recurrent pneumonia (HP:0006532)2.46400107
61Recurrent gram-negative bacterial infections (HP:0005420)2.45539160
62White forelock (HP:0002211)2.45133349
63Abnormal hair laboratory examination (HP:0003328)2.43781569
64Ectropion (HP:0000656)2.42227158
65Abnormality of carpal bone ossification (HP:0006257)2.42039703
66Intrahepatic cholestasis (HP:0001406)2.40504244
67Recurrent fungal infections (HP:0002841)2.40051907
68Reduced antithrombin III activity (HP:0001976)2.39816777
69Milia (HP:0001056)2.39220470
70Plantar hyperkeratosis (HP:0007556)2.36170214
71Rhinitis (HP:0012384)2.33939404
72Nonprogressive disorder (HP:0003680)2.33862568
73Neoplasm of the tracheobronchial system (HP:0100552)2.31871836
74Abnormal glucose tolerance (HP:0001952)2.30910053
75Aplasia/Hypoplasia of the fovea (HP:0008060)2.30190795
76Hypoplasia of the fovea (HP:0007750)2.30190795
77Congenital ichthyosiform erythroderma (HP:0007431)2.27901553
78Recurrent cutaneous fungal infections (HP:0011370)2.27713683
79Chronic mucocutaneous candidiasis (HP:0002728)2.27713683
80Increased IgM level (HP:0003496)2.27616021
81Keratoconjunctivitis sicca (HP:0001097)2.26702954
82Abnormality of chromosome stability (HP:0003220)2.25925444
83Posterior subcapsular cataract (HP:0007787)2.25905906
84Pigmentary retinal degeneration (HP:0001146)2.25847835
85Short nail (HP:0001799)2.25086812
86Hypothermia (HP:0002045)2.25078565
87Stomach cancer (HP:0012126)2.24746782
88Patchy hypopigmentation of hair (HP:0011365)2.24104406
89Periodontitis (HP:0000704)2.23009094
90Hyperkalemia (HP:0002153)2.22193825
91Abnormality of sodium homeostasis (HP:0010931)2.20680851
92Autoimmune thrombocytopenia (HP:0001973)2.20578312
93Mediastinal lymphadenopathy (HP:0100721)2.20033889
94Renal salt wasting (HP:0000127)2.19282101
95Obstructive lung disease (HP:0006536)2.18302458
96Chronic obstructive pulmonary disease (HP:0006510)2.18302458
97Curly hair (HP:0002212)2.17573531
98Abnormality of incisor morphology (HP:0011063)2.15679221
99Confusion (HP:0001289)2.14354857
100Pterygium (HP:0001059)2.14232145
101Bronchiectasis (HP:0002110)2.14223996
102Meckel diverticulum (HP:0002245)2.14061450
103Keratoconjunctivitis (HP:0001096)2.13984399
104Hoarse voice (HP:0001609)2.13595656
105Fragile nails (HP:0001808)2.13503093
106Aplasia cutis congenita (HP:0001057)2.12887026
107Vasculitis (HP:0002633)2.12572979
108Type I transferrin isoform profile (HP:0003642)2.12447966
109Abnormal respiratory motile cilium physiology (HP:0012261)2.12085518
110Pulmonary infiltrates (HP:0002113)2.10172804
111Abnormality of the 1st metacarpal (HP:0010009)2.10051128
112Cheilitis (HP:0100825)2.09588857
113Bronchitis (HP:0012387)2.06228724
114Alkalosis (HP:0001948)2.05847109
115Abnormality of small intestinal villus morphology (HP:0011472)2.05828941
116Villous atrophy (HP:0011473)2.05828941
117Muscle fiber atrophy (HP:0100295)2.05633606
118Abnormality of the nasal mucosa (HP:0000433)2.05600602
119Ectopic kidney (HP:0000086)2.05444276
120Abnormality of macrophages (HP:0004311)2.05129016
121Hypergonadotropic hypogonadism (HP:0000815)2.04981791
122Reduced subcutaneous adipose tissue (HP:0003758)2.04209307
123Absent/shortened dynein arms (HP:0200106)2.03753241
124Dynein arm defect of respiratory motile cilia (HP:0012255)2.03753241
125Fat malabsorption (HP:0002630)2.03366650
126Abnormal hand bone ossification (HP:0010660)2.03120131
127Abnormality of the ileum (HP:0001549)2.02638527
128Encephalitis (HP:0002383)2.01065916
129Palpitations (HP:0001962)2.00096041
130Mesomelia (HP:0003027)1.99587206
131Depressed nasal tip (HP:0000437)1.99333638
132Basal ganglia calcification (HP:0002135)1.98236500
133Recurrent skin infections (HP:0001581)1.98086511
134Subcapsular cataract (HP:0000523)1.97792698
135Conjugated hyperbilirubinemia (HP:0002908)1.97177277
136Conical tooth (HP:0000698)1.96808908
137Abnormality of the nasal septum (HP:0000419)1.96675153
138Easy fatigability (HP:0003388)1.96127191
139Severe short stature (HP:0003510)1.95442842
140Tubulointerstitial nephritis (HP:0001970)1.95438813
141Hypoproteinemia (HP:0003075)1.95371740
142Focal motor seizures (HP:0011153)1.95151881
143Ileus (HP:0002595)1.94101213
144Abnormal ciliary motility (HP:0012262)1.93293790
145Lip pit (HP:0100267)1.92857425
146Sensory axonal neuropathy (HP:0003390)1.92855876
147Meningitis (HP:0001287)1.92708183
148Elevated erythrocyte sedimentation rate (HP:0003565)1.90803346
149Abnormality of the renal cortex (HP:0011035)1.90751803
150Abdominal distention (HP:0003270)1.90339133
151Broad face (HP:0000283)1.90337336
152Xerostomia (HP:0000217)1.89749108
153Abnormality of the distal phalanges of the toes (HP:0010182)1.88813367
154Abnormality of the astrocytes (HP:0100707)1.88254465
155Astrocytoma (HP:0009592)1.88254465
156Palmoplantar hyperkeratosis (HP:0000972)1.87808502
157Prolonged bleeding time (HP:0003010)1.87748265
158Nasal polyposis (HP:0100582)1.86696674
159Abnormality of the distal phalanx of the thumb (HP:0009617)1.85407779
160Arterial tortuosity (HP:0005116)1.85383729
161Albinism (HP:0001022)1.84761675
162Aplasia/Hypoplasia of the tibia (HP:0005772)1.84703043
163Flattened epiphyses (HP:0003071)1.84407236
164Septo-optic dysplasia (HP:0100842)1.84254597
165Abnormal hair whorl (HP:0010721)1.84145571
166Abnormal auditory evoked potentials (HP:0006958)1.83134624
167Cervical subluxation (HP:0003308)1.82988756
168Premature loss of primary teeth (HP:0006323)1.82714296
169Osteomalacia (HP:0002749)1.82606548
170Adrenal overactivity (HP:0002717)1.82540769
171Recurrent lower respiratory tract infections (HP:0002783)1.82307298
172True hermaphroditism (HP:0010459)1.82080145
173Palmar hyperkeratosis (HP:0010765)1.80892265
174Abnormality of nail color (HP:0100643)1.80564833
175Median cleft lip (HP:0000161)1.80511560
176Thyroiditis (HP:0100646)1.79000955
177Tetany (HP:0001281)1.78602494
178Hypoplasia of dental enamel (HP:0006297)1.78340402
179Abnormality of male internal genitalia (HP:0000022)1.78220018
180Pustule (HP:0200039)1.78170414
181Petechiae (HP:0000967)1.77174218
182Keratitis (HP:0000491)1.76474821
183Eosinophilia (HP:0001880)1.72394886
184Autoimmune hemolytic anemia (HP:0001890)1.71707744
185Abnormality of the carotid arteries (HP:0005344)1.71216321
186Duodenal stenosis (HP:0100867)1.69173097
187Small intestinal stenosis (HP:0012848)1.69173097
188Abnormality of B cell number (HP:0010975)1.69053223
189B lymphocytopenia (HP:0010976)1.69053223
190Abnormality of the fovea (HP:0000493)1.68876603
191Hyperphosphatemia (HP:0002905)1.66753771
192Hemoptysis (HP:0002105)1.66207511
193Generalized hypopigmentation of hair (HP:0011358)1.65856142
194Glomerulopathy (HP:0100820)1.61330895
195Decreased central vision (HP:0007663)1.60753387
196Abnormal delayed hypersensitivity skin test (HP:0002963)1.59278663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM286.20526791
2MAP3K143.76011115
3IRAK33.46528322
4TXK3.17491148
5CASK2.87258954
6ZAK2.77819528
7IRAK42.49991928
8NUAK12.49697528
9EIF2AK22.48581720
10TNIK2.41223784
11FRK2.35832407
12MET2.29226016
13IKBKE2.23132727
14PRPF4B2.23131452
15ACVR1B2.19025949
16STK392.16959057
17MAP3K32.16399770
18EPHA41.96476465
19LATS11.87793462
20FER1.78925072
21STK38L1.75311250
22TBK11.68804585
23JAK31.67784636
24YES11.66981337
25JAK11.61644506
26BMPR21.59672868
27TEC1.57700816
28STK381.54607330
29SIK31.53051666
30KSR11.51370189
31INSRR1.49947680
32IKBKB1.46877681
33PLK41.45088604
34PRKCI1.44807806
35TRPM71.43683614
36ADRBK21.42199742
37TAOK31.42017895
38MST41.35661920
39AKT31.30997191
40LMTK21.30732102
41TAOK21.25478600
42MST1R1.24479168
43RIPK41.22244077
44BMPR1B1.19799169
45MINK11.18048765
46TYK21.17606741
47GRK71.16735032
48MAP2K71.16359463
49MUSK1.15985601
50BRSK21.15882723
51DAPK11.14764294
52CHUK1.14543222
53STK31.14524397
54SGK21.13039431
55STK101.11289876
56ERBB31.10992411
57MKNK21.06451419
58PBK1.05545582
59NEK91.04911061
60ICK1.02356384
61PTK2B1.01353536
62IRAK11.00498523
63TESK10.99806172
64KIT0.98111982
65CDK30.97469321
66PTK20.97264161
67ERBB40.96953489
68EPHA30.95842919
69GRK10.95039828
70OXSR10.93744728
71TIE10.92731737
72DAPK20.90655238
73TNK20.89776976
74BLK0.87304725
75MAP3K130.86681284
76STK160.86386095
77MAPKAPK30.85856576
78NEK60.83563903
79NLK0.83239792
80BRD40.82741765
81WNK40.82681523
82STK240.81953774
83PAK40.81932057
84MAP3K120.81723770
85MAP3K20.80264390
86CLK10.77424641
87LIMK10.76746291
88BCR0.74209569
89PIK3CG0.71878291
90MAPK130.71660067
91MAP3K60.70577958
92PIK3CA0.69443820
93LYN0.68184649
94SMG10.66565156
95PINK10.66297934
96EIF2AK10.65033523
97MAP2K60.62643310
98BTK0.61315446
99PIM10.60921881
100CDK80.60338172
101BUB10.59789761
102MAPK70.57672468
103EIF2AK30.55620985
104PRKCE0.55430892
105TGFBR20.55238739
106MKNK10.54186848
107SGK30.52822355
108LCK0.52264724
109FGFR30.51327414
110PRKG20.51259588
111TAOK10.50774440
112ATR0.49037630
113STK40.48267910
114SYK0.46554412
115ZAP700.46123366
116EPHA20.45963213
117MAP2K20.45632327
118HCK0.44683746
119SRPK10.44394300
120ITK0.43021686
121PIM20.42738198
122CSK0.42730634
123GRK50.42423802
124NME10.41597333
125ILK0.40918859
126IRAK20.40655373
127TTK0.40326523
128NTRK10.39942584
129MAP3K90.39466306
130MAPKAPK20.37404749
131CDK90.36997402
132MYLK0.36913690
133PRKCQ0.36517891
134SGK10.36364002
135PRKCD0.35924611
136CSF1R0.35245238
137PLK20.34776922
138PRKAA20.33705561
139BRSK10.32550618
140EPHB20.31316772
141ARAF0.30969278
142PAK30.30094868
143CAMK2D0.29628654
144LATS20.25130439
145ABL20.25053151
146MAP2K10.24626132
147RIPK10.24532827
148RPS6KB20.22421402
149MAPKAPK50.21700323
150IGF1R0.20695898
151DAPK30.20156404
152CSNK1A10.19617810
153MELK0.18247837
154CAMK2G0.16551464
155BRAF0.16335233
156MAPK110.14121990
157TESK20.13478383
158PTK60.13174962
159FLT30.12673287
160ERBB20.12394294

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.16813854
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.08476583
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.85449601
4Sulfur metabolism_Homo sapiens_hsa009202.71795933
5Allograft rejection_Homo sapiens_hsa053302.51159173
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.42892143
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.31883421
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.22686498
9Caffeine metabolism_Homo sapiens_hsa002322.19046153
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16735459
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.15039044
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.12775517
13Autoimmune thyroid disease_Homo sapiens_hsa053202.10521153
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05989996
15Toll-like receptor signaling pathway_Homo sapiens_hsa046202.01053456
16Measles_Homo sapiens_hsa051621.97668094
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.92907956
18Leishmaniasis_Homo sapiens_hsa051401.92627091
19Hematopoietic cell lineage_Homo sapiens_hsa046401.88265849
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88229782
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.86127356
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.84230165
23Chemical carcinogenesis_Homo sapiens_hsa052041.81873242
24Fanconi anemia pathway_Homo sapiens_hsa034601.80244673
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.76367716
26Nitrogen metabolism_Homo sapiens_hsa009101.75576255
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.74931458
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.73321945
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.70446617
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59571370
31Type I diabetes mellitus_Homo sapiens_hsa049401.58798116
32TNF signaling pathway_Homo sapiens_hsa046681.56994506
33Rheumatoid arthritis_Homo sapiens_hsa053231.55292636
34Herpes simplex infection_Homo sapiens_hsa051681.54298826
35Amphetamine addiction_Homo sapiens_hsa050311.53254542
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.53238456
37Malaria_Homo sapiens_hsa051441.52130590
38Influenza A_Homo sapiens_hsa051641.51706406
39Proteasome_Homo sapiens_hsa030501.50696574
40Primary immunodeficiency_Homo sapiens_hsa053401.46960501
41Vitamin digestion and absorption_Homo sapiens_hsa049771.43363778
42Sphingolipid metabolism_Homo sapiens_hsa006001.43180167
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38839409
44Other glycan degradation_Homo sapiens_hsa005111.36695250
45Fatty acid biosynthesis_Homo sapiens_hsa000611.32748259
46Tight junction_Homo sapiens_hsa045301.31072732
47Asthma_Homo sapiens_hsa053101.30215899
48Legionellosis_Homo sapiens_hsa051341.29919328
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28506433
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28140081
51Arachidonic acid metabolism_Homo sapiens_hsa005901.27962389
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27606855
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.27572923
54Fructose and mannose metabolism_Homo sapiens_hsa000511.20378055
55Osteoclast differentiation_Homo sapiens_hsa043801.20096157
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17380144
57Mineral absorption_Homo sapiens_hsa049781.17310129
58Non-homologous end-joining_Homo sapiens_hsa034501.16613412
59African trypanosomiasis_Homo sapiens_hsa051431.12507774
60Staphylococcus aureus infection_Homo sapiens_hsa051501.12370231
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12046237
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11025767
63Tuberculosis_Homo sapiens_hsa051521.10569139
64Arginine and proline metabolism_Homo sapiens_hsa003301.10245671
65Homologous recombination_Homo sapiens_hsa034401.09428955
66Pancreatic secretion_Homo sapiens_hsa049721.08222241
67Pertussis_Homo sapiens_hsa051331.07016733
68Glutathione metabolism_Homo sapiens_hsa004801.05744597
69Salivary secretion_Homo sapiens_hsa049701.04284313
70Bile secretion_Homo sapiens_hsa049761.02405580
71Renin secretion_Homo sapiens_hsa049241.01139543
72Hepatitis C_Homo sapiens_hsa051600.99157653
73Peroxisome_Homo sapiens_hsa041460.99152216
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98278911
75Fat digestion and absorption_Homo sapiens_hsa049750.97870684
76Arginine biosynthesis_Homo sapiens_hsa002200.93217088
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90608044
78Chemokine signaling pathway_Homo sapiens_hsa040620.89346937
79Phagosome_Homo sapiens_hsa041450.89223274
80Galactose metabolism_Homo sapiens_hsa000520.88452790
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88161057
82Salmonella infection_Homo sapiens_hsa051320.87815672
83Toxoplasmosis_Homo sapiens_hsa051450.86750570
84Ether lipid metabolism_Homo sapiens_hsa005650.86639374
85Base excision repair_Homo sapiens_hsa034100.83104951
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81027442
87Apoptosis_Homo sapiens_hsa042100.80050774
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.80021523
89Tyrosine metabolism_Homo sapiens_hsa003500.79017012
90Phenylalanine metabolism_Homo sapiens_hsa003600.77983947
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77458144
92PPAR signaling pathway_Homo sapiens_hsa033200.77220786
93ABC transporters_Homo sapiens_hsa020100.76578287
94Hepatitis B_Homo sapiens_hsa051610.74640967
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.73488311
96Fatty acid degradation_Homo sapiens_hsa000710.73070461
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72812379
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72341490
99Ovarian steroidogenesis_Homo sapiens_hsa049130.71493812
100Long-term potentiation_Homo sapiens_hsa047200.71223360
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71049704
102Glycerolipid metabolism_Homo sapiens_hsa005610.70420389
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70209591
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.69227467
105Thyroid hormone synthesis_Homo sapiens_hsa049180.68671334
106Renin-angiotensin system_Homo sapiens_hsa046140.68316338
107Tryptophan metabolism_Homo sapiens_hsa003800.66539984
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66071249
109Glucagon signaling pathway_Homo sapiens_hsa049220.64642881
110Basal transcription factors_Homo sapiens_hsa030220.63610756
111Steroid biosynthesis_Homo sapiens_hsa001000.62547503
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62204393
113Dorso-ventral axis formation_Homo sapiens_hsa043200.60624750
114Linoleic acid metabolism_Homo sapiens_hsa005910.58140801
115N-Glycan biosynthesis_Homo sapiens_hsa005100.57274125
116Gastric acid secretion_Homo sapiens_hsa049710.56946276
117Inositol phosphate metabolism_Homo sapiens_hsa005620.55661884
118Histidine metabolism_Homo sapiens_hsa003400.55614562
119Prolactin signaling pathway_Homo sapiens_hsa049170.53535259
120p53 signaling pathway_Homo sapiens_hsa041150.52896204
121Retinol metabolism_Homo sapiens_hsa008300.49686189
122Nicotine addiction_Homo sapiens_hsa050330.49522260
123Dopaminergic synapse_Homo sapiens_hsa047280.48898987
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48795794
125T cell receptor signaling pathway_Homo sapiens_hsa046600.47389457
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.46533519
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44006660
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42193398
129Small cell lung cancer_Homo sapiens_hsa052220.42081472
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40844060
131Proteoglycans in cancer_Homo sapiens_hsa052050.40699162
132Insulin secretion_Homo sapiens_hsa049110.40650189
133Calcium signaling pathway_Homo sapiens_hsa040200.40575330
134Adherens junction_Homo sapiens_hsa045200.40113296
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39765045
136Taste transduction_Homo sapiens_hsa047420.39694552
137Circadian rhythm_Homo sapiens_hsa047100.39605024
138Shigellosis_Homo sapiens_hsa051310.38563995
139Oocyte meiosis_Homo sapiens_hsa041140.38111980
140Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38015145
141Collecting duct acid secretion_Homo sapiens_hsa049660.37651148
142Lysosome_Homo sapiens_hsa041420.37223400
143Endocytosis_Homo sapiens_hsa041440.36731748
144Protein digestion and absorption_Homo sapiens_hsa049740.36538431
145Maturity onset diabetes of the young_Homo sapiens_hsa049500.36216871
146Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.36117977
147Leukocyte transendothelial migration_Homo sapiens_hsa046700.35875026
148Olfactory transduction_Homo sapiens_hsa047400.35348692
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.34686455
150Vibrio cholerae infection_Homo sapiens_hsa051100.34351098
151Biosynthesis of amino acids_Homo sapiens_hsa012300.34282468
152Propanoate metabolism_Homo sapiens_hsa006400.33405493
153AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32785052
154Regulation of autophagy_Homo sapiens_hsa041400.32452374
155B cell receptor signaling pathway_Homo sapiens_hsa046620.29188032
156beta-Alanine metabolism_Homo sapiens_hsa004100.28651635
157Cocaine addiction_Homo sapiens_hsa050300.28384901
158Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28249319
159Viral myocarditis_Homo sapiens_hsa054160.28159303
160Circadian entrainment_Homo sapiens_hsa047130.28013861
161Starch and sucrose metabolism_Homo sapiens_hsa005000.27362391
162Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27090234
163Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27072040
164Gap junction_Homo sapiens_hsa045400.26981345
165Fatty acid metabolism_Homo sapiens_hsa012120.26160775
166Antigen processing and presentation_Homo sapiens_hsa046120.25257913
167Purine metabolism_Homo sapiens_hsa002300.23935465
168RNA degradation_Homo sapiens_hsa030180.23716130
169Epstein-Barr virus infection_Homo sapiens_hsa051690.21546128
170Pancreatic cancer_Homo sapiens_hsa052120.21175909

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »